Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [value of the ultrasensitive assay of plasma tsh for the surveillance of replacement treatment in children with congenital hypothyroidism]. | this study proposes some improvements in monitoring congenital hypothyroidism (ch) using an ultrasensitive plasma tsh assay (ustsh). patients were 42 ch treated with levo-thyroxine (l-t4) for at least 6 months. controls were 25 age-matched children (c). comparative determinations of plasma tsh with classical radioimmunoassay (ria), on one hand, and ustsh on the other hand, revealed ria values to be beneath the sensitivity threshold in 3 c and in 15 ch. with ustsh, all the tsh values were assayed ... | 1988 | 3214248 |
| effects of thyroid hormones (t4,t3), bromocriptine and triac on inappropriate tsh hypersecretion. | inappropriate tsh hypersecretion was diagnosed in a 38-year-old woman (case 1) and in a 38-year-old man (case 2). both of them had earlier been treated by ablative therapy for hyperthyroidism. the present diagnosis was based on elevated basal serum tsh levels despite elevated serum free thyroid hormone levels. both of them had exaggerated tsh responses to trh (peak value 240 mu/l in case 1 and 408 mu/l in case 2). their albumin and prealbumin levels were normal. the serum tbg level was normal in ... | 1988 | 3214942 |
| optimum replacement dose of thyroid hormone assessed by highly sensitive tsh determination in patients with congenital hypothyroidism. | serum thyroid hormone concentrations were measured in 100 samples from 25 patients with congenital hypothyroidism who were clinically well while receiving l-t4 therapy. thyroxine concentrations were significantly higher than those of controls (p less than 0.01), while triiodothyronine was not significantly different. these samples were divided into four groups according to serum thyroid stimulating hormone concentrations as measured by highly sensitive immunoradiometric assay (irma-tsh). serum t ... | 1988 | 3215142 |
| effects of low dose l-triiodothyronine administration on mental, behavioural and thyroid states in elderly subjects. | decreased serum t3 concentrations in elderly subjects and their possible relationship with the development of dementia have been indicated. to see the effects of a passive increase in the serum t3 concentration, low dose t3 administration was undertaken. forty-four subjects from 65 to 93 years of age (average 81.0 +/- 7.8) were divided into 2 groups. the grade of dementia was determined by hasegawa's dementia rating scale (dr score). in 22 subjects, 25 micrograms per day of t3 was administered f ... | 1988 | 3215145 |
| prognostic factors in renal cell carcinoma. | in order to evaluate the prognostic factors of renal cell carcinoma (rcc), a retrospective study was carried out on 215 patients (150 men, 65 women) who had undergone surgical treatment from march 1979 to december 1986. the average age of the patients was 58 years (ranging from 15 to 85 years). the ratios of survival to tumor stage and grade, as well as to nodal and venous involvement, distant metastases at the time of diagnosis (as tnm classification) were evaluated by means of the actuarial me ... | 1988 | 3215240 |
| [transposition and myocutaneous island flaps in primary or secondary locoregional surgical therapy of breast cancer]. | new plastic surgical reconstruction techniques can today make a major contribution to locoregional therapy in breast cancer cases. the present paper reports on indications for and experience gathered in primary and secondary therapy with transposition (medial-pedicled thoracoepigastric) and myocutaneous island flaps (lower transversal rectus and latissimus dorsi) at the university gynecological clinic of heidelberg between october 1981 and june 1987. thirty-nine patients were treated using these ... | 1988 | 3215453 |
| [diurnal rhythm of thyroxine (t4), triiodothyronine (t3) and reverse triiodothyronine (rt3) secretion in women in the third trimester of uncomplicated pregnancy]. | 1988 | 3215565 | |
| an effective combined therapy for advanced squamous cell carcinoma of the oral cavity: preoperative bvmm (bleomycin, vincristine, mitolactol plus methotrexate and leucovorin) chemotherapy followed by surgery. | effects of preoperative chemotherapy with three courses of a combination of bleomycin, vincristine, mitolactol, prednisolone and methotrexate, with a leucovorin rescue, followed by surgery, were studied in 43 patients with advanced squamous cell carcinoma of the oral region. prior to chemotherapy 32 patients (74%) had advanced t3 or t4 carcinomas whilst 11 patients had t2 lesions. all patients responded clinically to preoperative chemotherapy: 20 patients (46%) achieved clinically complete remis ... | 1988 | 3216933 |
| results of treatment of uterine cervix cancer by radiotherapy. | the results of treatment of uterine cervix cancer by radiotherapy alone in 259 patients in the period january 1973 to december 1984 are reported. they are analyzed according to patients age, stage, tumor volume, extent of parametrial infiltration, hydronephrosis and nodal status. it is shown that age, tumor volume, extent of parametrial invasion and nodal metastases are the main prognostic factors. analysis of pelvic failures shows that external radiotherapy followed by curietherapy seems to be ... | 1988 | 3217541 |
| [carcinoma of the soft palate and uvula. an analysis of the results and the reasons for failures. a study of 76 cases]. | the treatment of carcinomas of the soft palate most often involves radiotherapy. in order to assess the value of irradiation, notably in the treatment of limited t1 or t2 tumours, a retrospective study was carried out of 76 case records suitable for analysis of patients treated in our hospital for this type of tumour between 1974 and 1987. there were 70 men and 6 women. the mean age was 54 years. fifty-four patients had limited t1 or t2 tumours (including 40 without lymphadenopathy). treatment m ... | 1988 | 3217737 |
| [concentration of thyroid hormones and thyrotropin in the blood of patients with chronic pancreatitis]. | concentrations of triiodothyronine (t3), thyroxine (t4), reflecting the thyroid status, and thyrotropin, a hormone of the anterior pituitary were investigated in 123 patients with exacerbation of chronic pancreatitis. t3 and t4 levels were considerably decreased, and a tsh level was raised (p less than 0.001). by the end of therapy the latter was markedly decreased, and t3 and t4 concentrations showed a rising tendency. the greatest changes in the levels of the thyroid hormones were observed in ... | 1988 | 3217881 |
| the influence of thyroid hormones on colony growth of peripheral cfu-gm from normal and leukemic subjects. | in order to clarify the alterations of granuloblastic cells in chronic and acute myeloid leukemia, the colony growth behavior of cultured cfu-gm from the peripheral blood of normal and leukemic subjects was examined in basal conditions and after adding to the medium t3 or t4 and/or thioproline and/or flurbiprofen. these drugs had in previous investigations proved their ability to modify cellular receptors and the uptake of thyroid hormones. the study was carried out in semisolid (double agar lay ... | 1988 | 3217984 |
| [lymphogenic metastasis in penile cancer]. | dissemination to regional lymph nodes was verified in 49 (18.8%) out of 260 cases of penile carcinoma. the frequency of metastasis in poorly differentiated squamous cell carcinoma was 2.2 times that in well-differentiated tumor. similarly, in endophytic growth patients, it was 2.7 times that of exophytic tumors. also, a significant correlation was established between the frequency of dissemination to lymph nodes and primary tumor size: 4.6% for t1, 19.3%--t2 and 30.9%--t3, respectively, and t4 w ... | 1988 | 3218152 |
| [advanced carcinoma of the oropharynx: the value of induction chemotherapy before locoregional treatment. a retrospective study of 138 cases]. | induction chemotherapy in oropharynx carcinomas had demonstrated overall response rates of 80%, but no overall survival benefit have been reported. in order to determine the value of induction chemotherapy for these patients, we conducted a retrospective study: 86 patients were treated with chemotherapy (ct) and rt (group 1) and 52 patients were treated by radiotherapy (rt) alone (group 2). all patients had t3 or t4 tumors. ct used was cisplatinum based associated with bleomycin and vincristine ... | 1988 | 3219424 |
| endocrine control of cytosolic factors stimulating adenylate cyclase in rat lung. | endocrine control of cytoplasmic factors modulating adenylate cyclase activity in rat lung membranes was investigated. hypophysectomy, adrenalectomy and thyroidectomy showed an adverse effect on the body and organ weights. lung protein, glycogen and dna contents were decreased in the endocrine ablated animals which were restored to the normal values on hormone treatment. phosphodiesterase and phosphorylase activities were increased and decreased in adrenalectomized and thyroidectomized animals, ... | 1988 | 3220445 |
| seasonal variations of glucose and triiodothyronine concentrations in serum of carp (cyprinus carpio l). | thyroid hormone and glucose serum concentrations (sc) of carps (cyprinus carpio l) have been monitored at weekly intervals throughout the year. t4 and rt3 concentrations were always below the limit of detection of the assays applied. t3 and glucose mean sc showed seasonal variations. highest t3 sc were reached in summer with a peak value in august and lowest values in winter with a maximum in december. glucose sc have been found to be highest in winter and lowest in summer. statistical analysis ... | 1988 | 3220447 |
| thyrotropin measured by the immunoradiometric assay in low birth weight infants. | in 37 infants, the blood levels of tsh were determined by the immunoradiometric assay (irma) and the relation between tsh and thyroid hormone was evaluated. the ranges of gestational age (weeks) and birth weight (g) of infants were 28-42 and 982-3,650, respectively. the birth weights of 19 infants were below 2,500 g. the free t4 levels in the low birth weight (lbw) infants were lower than those of the normal infants and significantly correlated to the birth weight (r = 0.64, p less than 0.01) an ... | 1988 | 3220452 |
| thyroid hormone analog inhibition of hepatic 5'-iodothyronine deiodinase activity. | studies using thyroid hormone analogs have provided insight into the structural requirements for thyromimetic activity and for thyroid hormone binding to thyroxine-binding globulin, thyroxine-binding prealbumin, and nuclear t3 receptors. to determine the structural specifications for iodothyronine interaction with 5'-iodothyronine deiodinase (5'-itd), we examined the ability of 35 thyroid hormone analogs to inhibit hepatic t4 5'-deiodination in vitro. the compounds were incubated in concentratio ... | 1988 | 3221042 |
| thyroid hormone kinetics during late pregnancy in the ovine fetus. | the factors responsible for the changes in the plasma concentrations of thyroid hormones in the ovine fetus in late pregnancy were investigated by making serial measurements of the concentrations, metabolic clearance rates and production rates of t3 and t4 in 17 fetuses. the concentrations of t3 in fetuses of 135-145 days gestational age were four times higher than in those of 110-125 days but the concentrations of t4 were unchanged. the metabolic clearance rate of t3 halved over this period whe ... | 1988 | 3221061 |
| effects of thyroxine on oestrogen receptor concentrations in anterior pituitary and hypothalamus of hypothyroid rats. | the effects of thyroxine (t4) were studied on the concentration of oestrogen receptors in the anterior pituitary gland and hypothalamus of ovariectomized euthyroid and hypothyroid rats. a group of rats was made hypothyroid by the administration of 131i. seven days after ovariectomy, animals were separated into five groups: i, euthyroid controls; ii, hypothyroid controls; iii, hypothyroid and injected with oestradiol benzoate (10 micrograms/day for 10 days); iv, hypothyroid and injected with t4 ( ... | 1988 | 3221152 |
| linear dichroism of the complex between the gene 32 protein of bacteriophage t4 and poly(1,n6-ethenoadenylic acid). | we performed linear dichroism measurements in compressed polyacrylamide gels on the complex between the helix-destabilizing protein of bacteriophage t4, gp32 and poly(1,n6-ethenoadenylic acid), which is used as a model system for single-stranded dna. a strong hyperchromism for poly(1,n6-ethenoadenylic acid) in the complex indicates a strongly altered conformation. the positive linear dichroism in the wavelength region where the bases absorb must be explained by a strong tilting of the bases in t ... | 1988 | 3221392 |
| effects of ad libitum versus restricted feeding on body composition and egg production of broiler breeders. | a 64-wk experiment was conducted in which the effects of ad libitum vs. restricted feeding were studied during the pullet-layer transition and laying periods. broiler breeder females were reared through 23 wk of age according to the breeder's recommendation. at 24 wk of age the following four treatments were imposed: t1, fed restricted amounts of feed according to the breeder's management guide; t2, feed restricted from 24 to 32 wk of age (as in t1), then fed ad libitum; t3, fed ad libitum from ... | 1988 | 3222185 |
| characterization of specific thyroid hormone receptors in bone. | thyroid hormones stimulate bone turnover in vivo and increase ca release from bone in vitro. to investigate further the effects of thyroid hormones in bone, we have characterized specific nuclear receptors for [125i]tri-iodothyronine (t3) in neonatal mouse calvaria. maximal specific binding of [125i]t3 to isolated nuclei occurred within 60 min at 22 degrees c. [125i]t3 binding was completely and rapidly displaced by the addition of 10(-6) m unlabeled t3; the dissociation appears to be first orde ... | 1988 | 3223358 |
| congenital hypothyroidism in scottish deerhound puppies. | two scottish deerhound puppies had clinical and pathological features consistent with the diagnosis of congenital non-goitrous hypothyroidism. they were from separate litters, but were the progeny of the same sire and dam. the puppies were smaller, had shorter limbs and shorter, broader heads than their littermates. they also had histories of weakness, difficulty in walking and somnolence. a characteristic radiographic feature was the absence of epiphyseal growth centres. both had depressed seru ... | 1988 | 3223852 |
| recombinant bovine somatotropin stimulates short term increases in growth rate and insulin-like growth factor i (igf-i) in chickens. | recombinant bovine somatotropin (rbgh) was administered by subcutaneous injection at daily doses of 0.5 or 2.5 mg/kg for a two week period in female broiler chicks between 4 and 6 weeks of age. half of the chicks received dietary corticosterone at a 1 ppm level. growth rate was significantly increased 6.1% and 6.9% following one week of treatment with 0.5 or 2.5 mg/kg rbgh respectively. treatment with the same respective doses of rbgh in the presence of 1 ppm corticosterone, supplied to suppress ... | 1988 | 3224522 |
| [effect of hypercalcemia and calcitonin on changes in the left-ventricular systolic time interval and t3 and t4 secretion in hyperthyroidism and euthyroid goiter]. | 1988 | 3224591 | |
| [triiodothyronine(t3) autoantibodies in a woman with nonthyroidal disorder: a study on preparation of serum igg fraction employing protein a column chromatography]. | a 48-year-old non-goitrous woman, who had undergone cardiac surgery for mitral stenosis under the extracorporeal circulation, showed high levels of serum t3 and free t3 in a recent follow-up study, employing antibody coated-bead ria for t3 and -amerlex m particle ria for free t3. however, other thyroid function tests (t4, free t4, tsh and tbg) were normal. we suspected that thyroid hormone autoantibodies (thaa) in her serum interfered with t3 and free t3 analyses. the presence of thaa was demons ... | 1988 | 3224724 |
| a multisite-directed mutagenesis using t7 dna polymerase: application for reconstructing a mammalian gene. | a method to introduce multiple mutations and to reconstruct genes, using a single oligodeoxyribonucleotide and dna polymerase with high processivity, such as modified t7 dna polymerase [tabor and richardson, proc. natl. acad. sci. usa 84 (1987a) 4767-4771], is described. a eukaryotic cdna, coding for porcine growth hormone (pgh), was reconstructed in this study to delete 75 bp and to introduce a g----a transition. the deletion removes 75 bp and brings an atg just upstream from the codon for the ... | 1988 | 3224824 |
| effect of confinement method on physiology and production of gestating gilts. | four replicates of 12 dekalb crossbred gilts were blocked by breeding dates and randomly allotted to four treatments: tethers, crates, loose stalls and dirtlot. ear vein cannulas were established and blood samples obtained from each gilt on d 2, 9 and 65 of treatment blood cell counts, blood chemistry profile (12 items), triiodothyronine (t3), thyroxine (t4), basal cortisol and cortisol in response to administration of adrenocorticotrophic hormone (cr-acth) were determined. tethered gilts had de ... | 1988 | 3225244 |
| thyroxin induced moult in domestic hen. | two identical experiments were carried out in domestic hens treated with a lower (0.2 mg/animal) or a higher (0.4 mg/animal) dose of thyroxin (t4), for 21 consecutive days. the low dose diminished egg production, but did not result in moulting while the higher dose stopped egg laying on the 16th day and caused the loss of contour feathers from the 14th day on. the new plumage was completely developed in this group on about the 42th day. the plasma progesterone concentration showed an increase in ... | 1988 | 3227854 |
| serum levels of thyroid and adrenal hormones, testosterone, tsh, lh, gh and prolactin in men after a 2-h stay in a cold room. | twenty healthy male volunteers, dressed in shorts, stayed for 30 min in a room with an ambient temperature of 28 degrees c followed by a stay in a room with a temperature of 10 degrees c for 120 min. the mean skin temperature fell rapidly during the first minutes in the cold but the rectal temperature began to fall as late as at 60 min (0.1 degree c) and was 0.4 degrees c lower at the end of the cold exposure than before it. the metabolic rate, and the systolic and diastolic blood pressures, inc ... | 1988 | 3227893 |
| creatine kinase in hypo- and hyperthyroid rats under consideration of the circadian oscillations. | thyroxine level (t4) and total creatine kinase-activity (ck) were measured in serum samples from male wistar-rats to investigate the relationships of serum titers after exposure to cold and thyroidectomy (tx). 72 hours exposure to cold (10 degrees c) produced a statistically significant elevation of t4 and a diminuation of ck-activity. in contrast to this protocol, tx (90 days after operations) reduced the t4 level and enhanced the ck-activity. these reactions were likewise statistically signifi ... | 1988 | 3229453 |
| [importance of changes in plasmatic volume in the evaluation of tsh, l-t3 and l-t4, during muscular activity]. | the changes in plasma concentrations of tsh and thyroid hormones (l-t3 and l-t4), lactate, proteins and ffa were studied in 8 male volunteers undergoing maximal exercise during 12 min on the bicycle ergometer from 1 to 4 w/kg. serial blood samples were taken at -30, 0, 3, 6, 9, 12, +3, +15 and +30 min intervals. all samples for tsh, l-t3 and l-t4 measurements were processed by radioimmunoassay. the possibility of interference in the ria determination, with protein and ffa, has been studied in th ... | 1988 | 3231887 |
| pituitary thyrotroph hypofunction in aged euthyroid subjects as assayed by the administration of iopanoic acid. | iopanoic acid, an iodine containing contrast medium was administered orally to healthy subjects aged 20-40 years (n = 9) and 70-90 years (n = 10) and also to sick aged persons (aged 70-90 years, n = 10). thyroid hormones: t4, t3, rt3, t3-uptake and thyrotropin (tsh) serum levels were estimated before and three and seven days after iopanoic acid. no significant tsh increase could be seen in the old-age groups: the t4 increases were similar in all three groups as well as the slight t3 decreases; t ... | 1988 | 3232419 |
| improved antigenicity of the hiv env protein by cleavage site removal. | the hiv env glycoprotein mediates virus infection and cell fusion through an interaction with the cd4 molecule present at the surface of t4+ lymphocytes. although env presents a major antigenic target, vaccinia recombinants expressing env elicit low titres of anti-env antibody (kieny et al., bio/technology, 4, 790-795, 1986). to delimit the functional domains of env and to improve the immunogenicity of the vaccinia recombinants we constructed variants expressing env proteins in which the site pe ... | 1988 | 3237686 |
| metabolic clearance and production of diiodotyrosine in healthy man. | metabolic clearance rate (mcr) and daily production rate (pr) of diiodotyrosine (dit) were estimated using a constant infusion technique of trace amounts of [125-i]-dit followed by chromatographical isolation of tracer. median dit mcr was in eight healthy subjects estimated to 162 l/day x 70 kg (range 135-242), whereas pr was 52 nmol/day x 70 kg (range 25-126). the median serum dit concentration was 0.27 nmol/l (range 0.16-0.62). in five l-thyroxine substituted subjects without endogenous thyrox ... | 1988 | 3238320 |
| kinetics of lymphocyte subpopulations in dengue hemorrhagic fever/dengue shock syndrome. | a kinetic study of lymphocyte subpopulations was performed in 61 dengue hemorrhagic fever/dengue shock syndrome (dhf/dss) patients aged 8 months to 12 years and in 59 age-matched normal controls. there were 36 patients in grade 2 and 25 patients in grade 3 of the disease severity. the studies were performed on febrile stage, the day of subsidence of fever or shock stage, 3 subsequent days after subsidence of fever or shock, and once on the recovery stage (approximately 14-18 days after subsidenc ... | 1988 | 3238478 |
| a time-course study of hypothyroidism-induced hypotension: its relation to food deprivation. | concentrations of 0.05, 0.01 and 0.2% propylthiouracil (ptu), incorporated into standard rat chow, induced hypothyroidism in male sprague-dawley rats following 6-8 weeks administration. the concentrations caused a progressive decrease in arterial blood pressure (bp), heart rate (hr), body weight (bw), food intake (fi), levels of triiodothyronine (t3), thyroxine (t4) and an increase in thyrotropin (tsh) levels. there was no clear-cut dose-dependent change in these parameters, since the values obt ... | 1988 | 3240019 |
| on the role of homologous sequences in chromosomal rearrangements. | deletions and other chromosomal rearrangements can be generated by recombination between repeated sequences. it has been shown in a number of systems that the probability of exchange or gene conversion decreases with increasing distance between repeats. this paper examines the question of how repeats find each other, using deletion formation in bacteriophage t4 as a model system. homologous sequences adjacent to the repeats can either stimulate or inhibit recombination, depending on their orient ... | 1988 | 3240860 |
| intermolecular interactions between protein and other molecules including hydration effects. | the structural aspects of protein functions, e.g., molecular recognition such as enzyme-substrate and antibody-antigen interactions, are elucidated in terms of dehydration and atomic interactions. when a protein interacts with some target molecule, water molecules at the interacting regions of both molecules are removed, with loss of the hydration free energy, but gaining atomic interactions between atoms of the contact sites in both molecules. the free energies of association originating from t ... | 1988 | 3240986 |
| bacteriophage t4 resistant mutants of the plant pathogen erwinia carotovora. | bacterial lipopolysaccharide (lps) has been implied in a variety of pathogenic and symbiotic plant-bacterium interactions. in order to study the role of lps in pathogenicity of erwinia carotovora, a broad host range phytopathogen, we isolated lps defective mutants of two subspecies of erwinia carotovora, subsp. carotovora (ecc) and subsp. astroseptica (eca). this was accomplished by using the escherichia coli phage t4 as a selective agent. screening of erwinia isolates revealed that some of them ... | 1988 | 3241545 |
| binding parameters of rat liver nuclear receptors for t3 after partial hepatectomy or bilateral adrenalectomy and serum t4 and t3 levels. | nuclear receptor affinity (ka) and maximal binding capacity (mbc) for 3,5,3'-triiodothyronine (t3) in rat liver was estimated at 1, 12, 24, 48 and 120 hours after partial hepatectomy and 1, 24, 30, 40 and 120 hours after bilateral adrenalectomy and related to serum t4, t3 levels. soluble t3 receptor fraction was prepared from purified rat liver nuclei and the values of ka and mbc were calculated by scatchard plot analysis from the saturation curves. as compared to sham operated rats a significan ... | 1988 | 3243202 |
| thyroid hormones in genetically lean or fat chickens: effects of age and triiodothyronine supplementation. | thyroid hormones were measured in plasma of genetically lean (ll) or fat (fl) chickens at different ages. no differences were observed at hatching or at adult age. more triiodothyronine (t3) and less thyroxine (t4) were found in the plasma of ll than in fl at the fed state during the growth period. this difference disappeared as the birds approached sexual maturity. dietary supplementation by t3 increased the plasma concentration of t3 at the fed state. it did not influence growth rate, feed eff ... | 1988 | 3244897 |
| [neonatal screening for congenital hypothyroidism. reflections on the methodology based on a statistical analysis of tsh and t4]. | 1988 | 3246989 | |
| [characteristics of the clinical picture, hormonal status and humoral immunity in older patients with diffuse toxic goiter]. | radioimmunoassays, immunological and radioreceptor methods were used for a study of the levels of t3, t4, tsh, thyroglobulin, antibodies to thyroglobulin and microsomal antigen, immunoglobulins suppressing thyrotropin binding in 92 patients with diffuse toxic goiter aged over 50. there was discrepancy between the prevalence of severe types of disease in this group of patients and an insignificant rise of t3 and t4 levels. changes in the immune status pointed to an increase in immunodeficiency wh ... | 1988 | 3247664 |
| the construction of the hybrid plasmid containing genes of the central part of phage t4 baseplate and gene 29 product separation. | a fragment of e. coli bacteriophage t4 genome including the four genes (genes 51, 27, 28, 29) coding for the central plug proteins was cloned into plasmid pmcc17. the genes present on this fragment were expressed in e. coli in the absence of phage infection producing hub proteins, which could be identified on polyacrylamide gels. by applying affinity chromatography protein 29 was purified from extracts of e. coli transformed with this hybrid plasmid. the isolated protein had the ability to compl ... | 1988 | 3247809 |
| thyroid function in hemidecorticate rats. | 1. thyroid function was evaluated in hemidecorticate (hd) and control (c) rats by determining serum t3 and t4 levels and the development of incisors and mandibles and through analysis of various histological features of the thyroid such as follicle size, colloid droplet content and [3h]-glycine uptake by follicular cells. 2. hd animals presented normal levels of circulating t3 but significantly lower t4 levels. 3. there was slight atrophy of the gland in hd animals and fewer colloid droplets wer ... | 1988 | 3248242 |
| [preliminary analysis of 18 cases of malignant lymphoma by immunohistological method with various monoclonal and polyclonal antibodies]. | eighteen cases of malignant lymphoma were labelled by abc immunohistologic method with various monoclonal and polyclonal antibodies. it was found that all were okt9 antiserum positive and cytokeratin negative. in b cell lymphomas, 9/18 cases were positive for b1; 7 positive for each of i2+ and leu 10+; 6 for j5+, and 5 for b2+. in 6 cases of t cell lymphoma, 5 cases were positive for t3+ and tac+ each; 4 for t11+ and 2 for t6+ while all were positive for t4 and negative or weakly positive for t8 ... | 1988 | 3248483 |
| single amino acid changes which alter the sequence specificity of the t4 and t2 (dam) dna-adenine methyltransferases. | 1988 | 3248730 | |
| [cloning and study of the structural organization of regions of the inh(lip)-hoc genes of bacteriophage t4]. | 1988 | 3250843 | |
| thyroid functions before and after maintenance hemodialysis in patients with chronic renal failure. | to study the factors involved in the low thyroid hormone levels in patients with chronic renal failure (crf), we investigated thyroid functions just before and after hemodialyses (hd) in 32 such patients who were on maintenance hd. in addition, we measured serum thyroid hormone binding inhibitor activities (thbi) in another set of 37 patients. none of the patients had been suspected of having thyroid diseases. hd duration and aging did not have a significant effect on the results of the thyroid ... | 1988 | 3250862 |
| lack of effect of 3,3'5'-triiodothyronine (reverse t3) on cardiac function in the rabbit. | in a recent study, we have shown that the antiarrhythmic drug, amiodarone caused significant elevations of serum rt3 levels and inhibition of the peripheral conversion of t4 to t3 (kannan et al. endocrinology 115:1710-1716, 1984). in this study we have examined whether or not rt3 has a direct effect on the monodeiodinase enzyme activity and electropharmacology of the rabbit myocardium. six male new zealand white rabbits were administered 50 ug rt3 (a dose about 100 times the daily rt3 production ... | 1988 | 3250865 |
| kaposi's sarcoma in zimbabwe. ii. peripheral lymphocytes, immunoglobulin g levels and hiv antibody positivity. | patients with kaposi's sarcoma (ks) were grouped according to their clinical symptoms into "indolent", "locally aggressive", "endemic generalised aggressive" and "epidemic generalised aggressive" disease. only the patients in the epidemic generalised aggressive disease group had serum antibodies to hiv. complete peripheral blood counts, including lymphocyte subsets, and serum igg assays were performed on all patients before treatment was initiated. in all the aggressive disease groups there was ... | 1988 | 3251044 |
| restoration of normal thyrotrophin secretion reduces the abnormally high serum glutathione s-transferase levels found in patients receiving thyroxine replacement therapy. | the peripheral tissue thyroid status of 12 patients receiving thyroxine replacement therapy was investigated both when pituitary secretion of tsh was suppressed and later, when on a lower dose of thyroxine that restored thyrotroph responsiveness. heart rate and various analytes in serum known to be sensitive to thyroid status were measured in addition to tsh by immunoradiometric assay. initially, the serum t4 concentration was raised in seven patients and free t4 raised in nine; all patients had ... | 1988 | 3251666 |
| higher than conventional doses of carbimazole in the treatment of thyrotoxicosis. | in order to ascertain whether higher than conventional doses of carbimazole achieve more rapid control of thyrotoxicosis, 30 thyrotoxic patients were alternately allocated into two groups, group 1 (15 subjects) receiving a conventional starting dose of 45 mg orally daily and group 2 (15 subjects) a dose of 100 mg orally. in addition to weekly estimations of serum t4, t3, free t4, free t3 and tsh, the systolic time intervals ratio (sti), a measure of left ventricular contractility, was calculated ... | 1988 | 3251667 |
| [controlled ligation of oligodeoxyribonucleotides of dna-ligase of the t4 phage]. | the enzymatic ligation of 5-10-membered synthetic oligodeoxyribonucleotides forming the complementary dna-like duplexes has been studied. the possibility of selective dna ligase catalyzed ligation of 5'-adenylylated derivatives of oligonucleotides in the absence of ratp and also the selective joining of cohesive ends in the presence of blunt ends in the complex mixtures of oligonucleotides at definite concentrations of ratp have been demonstrated. the influence of length and sequence of short sy ... | 1988 | 3252153 |
| metabolic and thyroidal responses to mild cold are abnormal in obese diabetic women. | mild cold exposure (22 degrees c, with reference to 28 degrees c, thermoneutral) was studied by overnight whole-body indirect calorimetry in euthyroid women. basal, sleeping, energy expenditure (ee) was significantly increased (+3.8%, p less than 0.05) in six normal weight women but reduced (-3.5%, p less than 0.05) in five obese type ii diabetic women. mixed responses were found in five women with simple obesity. biochemical measurements were made on fasting blood samples taken at 0900 h after ... | 1988 | 3254262 |
| effect of thyroidectomy on the release of prolactin in vitro response to calcitonin. | chinese j. physiol. 31(2):105-112, 1988. the effect of calcitonin (ct) on the release of prolactin (prl) and thyrotropin (tsh) in vitro from anterior pituitary glands (aps) of thuroidectomized (tx) and intact male rats was investigated. male rats were tx or sham tx, then sacrificed 47 days later. aps were removed, quartered and incubated with ct (0 or 32 microiu/ml) and/or thyroxine (0 or 0.1 microgram/ml) at 37 degrees c for 4 h. thyroidectomy significantly decreased prl release in vitro. ct in ... | 1988 | 3255550 |
| hyperiodothyroninaemia of neonates, its significance for thermogenesis. | danowski et al. (1951) were probably the first who showed an increase of pbi in infants shortly after birth. later a number of investigators presented further evidence on the increased thyroid gland function in newborns. this condition named "neonatal thyroid hyperactivity" [fisher and oddie, 1964] was described also in animals. the available data indicate that all the newborn mammals till now studied, independently of the maturation stage of development they reach at birth, display some feature ... | 1988 | 3257052 |
| alterations in thyroid hormone physiology induced by temperature and feeding in newly hatched chickens. | in the chicken the transition of a poikilotherm to a homeotherm reaction upon cold exposure takes place in the perinatal period between pipping and hatching. however, newly hatched chicks cannot maintain their body temperature within narrow limits after cold exposure. the fact that relatively little attention was payed on the role of thyroid hormones in the thermoregulatory reaction to cold of young chicks was probably due to the hypothetically long latention time that was thought to be necessar ... | 1988 | 3257053 |
| in vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. | site-specific mutagenesis was used to introduce amino acid substitutions at the asparagine codons of four conserved potential n-linked glycosylation sites within the gp120 envelope protein of human immunodeficiency virus (hiv). one of these alterations resulted in the production of noninfectious virus particles. the amino acid substitution did not interfere with the synthesis, processing, and stability of the env gene polypeptides gp120 and gp41 or the binding of gp120 to its cellular receptor, ... | 1988 | 3257102 |
| improvement of four patients with hiv-1 related symptoms after hyperimmunization with killed poliomyelitis (salk) vaccine. | four hiv-1 positive patients with characteristic symptoms of this infection experienced amelioration or resolution of symptoms after 2 months of hyperimmunization with inactivated (salk) poliomyelitis vaccine. the patient who was initially the most symptomatic exhibited a marked improvement in t4/t8 ratio at the sixth month of continued hyperimmunization treatment. with two patients reported previously, six consecutive patients with lymphotropic retrovirus disease have benefited from hyperimmuni ... | 1988 | 3257176 |
| enhancement of antigen- and mitogen-induced human t lymphocyte proliferation by tumor necrosis factor-alpha. | the capacity of human recombinant tumor necrosis factor-alpha (rtnf alpha) to modulate human t cell proliferation was examined. to examine the effect of rtnf alpha on the responding t cell directly, t cell activation was studied in the absence of viable accessory cells (ac). highly purified ac-depleted peripheral blood t4 or t8 cells were stimulated with immobilized monoclonal antibodies to the cluster of differentiation (cd)3 molecular complex, an ac-independent stimulus. rtnf alpha augmented a ... | 1988 | 3257243 |
| increase in leu 2+ leu 7+ lymphocytes in hiv 1-seropositive patients with hemophilia repeatedly treated with clotting factor concentrates. | the fact that patients with hemophilia treated with clotting factor and hiv 1-seronegative subjects with congenital anemias given repeated blood transfusions both have decreased ratios of t4/t8 lymphocytes and diminished nk cell activity indicates that these immunological abnormalities can be due to repeated exposure to blood and blood products, and are not necessarily indicative of hiv 1 infection. to search for an immunological change specific for hiv 1 infection we tested 36 hemophiliacs (22 ... | 1988 | 3257429 |
| the ontogeny of iodothyronine 5'-monodeiodinase activity in rana catesbeiana tadpoles. | generation of t3 from t4 in vivo cannot be demonstrated in tadpoles until just before metamorphic climax (mc). possible explanations include the absence of the necessary 5'-monodeiodinase (5'd) process, and/or the presence of an active t3 and t4 5-deiodinase (5d) system before mc. in the present study, 5'd activity was determined in the 12,000 x g supernatent fraction of tissue homogenates prepared from tadpoles in premetamorphosis (pm) and mc (induced by immersion in 2 x 10(-8) m t4) by measuri ... | 1988 | 3257441 |
| t4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or hiv infection. | the t4 (cd4) molecule has been shown to facilitate the interactions of t cells with hla class ii determinants, to function as a signal transducing molecule, and to serve as a receptor for hiv. recent studies demonstrated that both phorbol esters and antigen stimulation induced the rapid and transient modulation and phosphorylation of t4 on an il-2-dependent line of cloned peripheral blood t4+ cells. in the current study, we define the kinetics of t4 phosphorylation and internalization induced by ... | 1988 | 3257504 |
| a soluble form of cd4 (t4) protein inhibits aids virus infection. | cd4 (t4) is a glycoprotein of relative molecular mass 55,000 (mr 55k) on the surface of t lymphocytes which is thought to interact with class ii mhc (major histocompatibility complex) molecules, mediating efficient association of helper t cells with antigen-bearing targets. the cd4 protein is also the receptor for hiv, a t-lymphotropic rna virus responsible for the human acquired immune deficiency syndrome (aids) (refs 4-7). to define the mechanisms of interaction of cd4 with the surface of anti ... | 1988 | 3257544 |
| influence of t lymphocytes on hematopoiesis in a patient with t cell hypoplasia. | in this communication, we describe an unusual patient with a reported lifelong history of anemia. investigation of the pathogenesis of this patient's bone marrow failure provided an interesting opportunity to determine the role of t cells in the regulation of human blood cell production. phenotyping of the patient's mononuclear cells revealed severe t cell hypoplasia in both the peripheral blood and bone marrow. the patient's bone marrow was capable of producing 50-60% of the normal numbers of b ... | 1988 | 3257644 |
| t lymphocytes in aortic and coronary intimas. their potential role in atherogenesis. | in order to investigate the role of mononuclear cells in infiltrates during the initial stages of atherogenesis, the authors have studied by immunohistochemical methods the aortas and coronary vessels of children and young adults (ages 15-34) dying of acute trauma. eccentric intimal thickening often accompanied by intimal mononuclear cell infiltration was commonly observed in sections of the lower thoracic aorta. these changes were usually related to intercostal branching sites and thus greater ... | 1988 | 3257650 |
| immunologic indices in myelodysplastic syndromes. | immunocompetence was evaluated in 36 untreated and noninfected patients affected with myelodysplastic syndromes (mds). t-cell number and activity were evaluated by counts of total t-cells and t-lymphocyte subsets, and by measure of dna synthesis in response to phytohemagglutinin and concanavalin a. b-cells were evaluated as surface immunoglobulin- (sig+) bearing cells and by serum immunoglobulin levels. granulocyte activities were evaluated by responses to chemotaxis and to nitroblue tetrazolium ... | 1988 | 3257709 |
| malignant thymoma with peripheral blood lymphocytosis. | a 37-year-old woman with a giant, lymphocytic predominant thymoma involving the pleura and accompanied by a sharp peripheral blood lymphocytosis is described. only electromicroscopic and immunohistologic studies could exclude the alternative diagnosis of mediastinal lymphoma. the tumor and peripheral blood lymphocytes were characterized as t4 lymphocytes. the thymoma responded very well to a combination of radiation and cytotoxic therapy. forty-two months after diagnosis, the patient is still is ... | 1988 | 3257710 |
| pathogenetic role of hiv infection in kaposi's sarcoma of equatorial east africa. | thirty residents of north-central tanzania with various forms of kaposi's sarcoma (ks) were evaluated. the absolute number of peripheral blood okt4 lymphocytes in patients and tanzanian control subjects tended to be low (in comparison with healthy young american adults), and many had inverted t4/t8 ratios. plasma polyclonal beta- and gamma-globulin concentrations were increased in many patients with ks and in control patients in tanzania with chronic dermatopathies, but not in african hospital e ... | 1988 | 3257865 |
| microsomal antigen-reactive lymphocyte lines and clones derived from thyroid tissue of patients with graves' disease. | thyroid mononuclear cells (tmc) were maintained in long term cocultures with thyroid fibroblasts and thyroid epithelial cells from patients with graves' disease, using medium supplemented with thyroid microsomal antigen (mcag) and il-2. the tmc consisted predominantly of t4+ (cd4+, helper) and, to a lesser extent, t8+ (cd8+, cytotoxic/suppressor) lymphocytes, with a small number of macrophages and natural killer cells. the average t4+ to t8+ ratio was 3.2. from these cultures we obtained thyroid ... | 1988 | 3257970 |
| natural variants of human immunodeficiency virus from patients with neurological disorders do not kill t4+ cells. | human immunodeficiency virus (hiv) has selective t4-cell tropism and is cytocidal to cells with the helper-inducer phenotype. central nervous system dysfunctions can complicate full-blown acquired immunodeficiency syndrome (aids) but can also be present either in isolation or in the context of aids-related complex. remarkably bland histopathological findings have been reported in some patients with aids dementia in the presence of severe clinical dysfunction. thus, to understand the cytopathic p ... | 1988 | 3258141 |
| interleukin 2 production in bone marrow of normal individuals and patients associated with b-cell chronic lymphocytic leukaemia. | t-cells from patients with b-cell chronic lymphocytic leukaemia (b-cll) have abnormal t4/t8 ratios and functions. previously, we demonstrated that peripheral blood (pb) mononuclear cells from b-cll patients secrete significant amounts of interleukin 2 (il2) with an apparent dysregulation of accessory cells controlling this production. in this study, il2 production was investigated in pb and in bone marrow (bm) from patients with previously untreated b-cll, mostly in early stages of the disease, ... | 1988 | 3258160 |
| effects of cyclosporin on t-cell subsets in human immunodeficiency virus disease. | cyclosporin (7.5 mg/kg daily) was given to 8 aids patients for 17-66 days and to 25 hiv-seropositive non-aids patients, 15 with stage ii (t4 cells/microliter greater than or equal to 300, less than 600) and 10 with stage iii (t4/microliter less than 300), for 3-6 months with the hypothesis that the drug could inhibit both hiv replication and the potential autoimmune component of hiv disease. a sustained increase over 600 t4/microliter occurred in 7 patients with stage ii and 1 with stage iii. t8 ... | 1988 | 3258211 |
| a maximum of two tryptophan residues in gene-32 protein from phage t4 undergo stacking interactions with single-stranded polynucleotides. | the effect of specific photochemical and radiochemical modification of tryptophyl and cysteinyl residues of the gene 32 protein (gp 32) of bacteriophage t4 on its affinity towards single-stranded polynucleotides has been investigated. oxidation of cys residues of gp 32 by the free-radical anion i-.2 induces a partial loss of the protein affinity, probably by affecting the metal-binding domain which includes three of the four cysteine residues of gp 32. ultraviolet irradiation of gp 32 in the pre ... | 1988 | 3258237 |
| evaluation of lymphocyte activation in skin lesions of patients with mixed connective tissue disease and discoid lupus erythematodes. | biopsy specimens from mixed connective tissue disease (mctd) and discoid lupus erythematodes (dle) skin lesions were stained with monoclonal antibodies to differentiation and activation antigens. in addition, the blast cells were studied by combining autoradiography with immunoperoxidase staining. in both disease conditions most of the inflammatory cells in situ were positive for t11 antigen, the cd4/cd8 ratio being low. only a few of the cells were pan-b positive b cells. the expression of vari ... | 1988 | 3258500 |
| characterization of the acute clinical illness associated with human immunodeficiency virus infection. | the clinical and serologic features and immune status of 39 homosexual men who had seroconversion to human immunodeficiency virus positivity were compared with 26 homosexual men who remained seronegative during a six-month period. an acute clinical illness occurred in 92.3% of seroconverted subjects and 40% of controls. the duration of illness was significantly greater in the seroconverters than the controls (10 + 4.4 days). a general practitioner was consulted by 87.2% of the seroconverters bec ... | 1988 | 3258508 |
| energy costs of walking and standing with functional neuromuscular stimulation and long leg braces. | two complete paraplegic subjects (t4 and t8), implanted with intramuscular electrodes, walked via functional neuromuscular stimulation (fns) using a rolling walker and a reciprocal gait. the subjects also ambulated with long leg braces (llb), using a rolling walker, and a drag/swing-to gait; and they stood using llb and fns separately. oxygen consumption (vo2), carbon dioxide production (vco2), respiratory exchange ratio (vco2/vo2), kcal/kg/meter, kcal/kg/minute, heart rate, blood pressure, and ... | 1988 | 3258509 |
| heat cleavage of bacteriophage t4 gene 23 product produces two peptides previously identified as head proteins. | during studies on the intracellular protein pools of bacteriophage t4, we found that amber mutants in gene 23 blocked the synthesis of a 20-kilodalton (kda) protein. radiolabeled amino acid pulses showed that the protein appears at 8 min postinfection with kinetics similar to those of other major late species. pulse-chase experiments demonstrated that the 20-kda protein behaves like a primary product and also revealed a 29-kda protein which, like other proteins cleaved during head assembly, appe ... | 1988 | 3258639 |
| unusual t4-positive b-chronic lymphoid leukemia cells. | 1988 | 3258796 | |
| iodothyronine 5'-deiodinase activity in the amphibian rana catesbeiana at different stages of the life cycle. | in a previous study, 5' deiodinase (5'd) activity was detected in skin but not in other tissues of premetamorphic tadpoles. when these tadpoles were stimulated to metamorphic climax by treatment with thyroid hormone, activity was increased in skin and was found also in gut and tail tissue. in the present study, 5'd activity was studied at various stages of spontaneous development from early prometamorphosis through metamorphic climax and including the adult frog. 5'd activity was detected in gut ... | 1988 | 3258817 |
| intracellular activation signal requirements for the induction of il-2 responsiveness in resting t cell subsets in humans. | activation signal requirements for the induction of the il-2 responsiveness in purified subsets of human resting t cells, t4+ or t8+, have been investigated under the monocyte-depleted conditions. substantial levels of il-2 responsiveness were induced in t8+ cells by lectin, con a, mab directed against the cd3 ag, okt3, ca2+ ionophore, ionomycin or phorbol ester, pma. in contrast, none of these stimuli was by itself sufficient for the induction of il-2 responsiveness in the t4+ subset. the latte ... | 1988 | 3258883 |
| [monoclonal antibody assessment of lymphocyte subpopulations in rheumatoid arthritis in adult patients in relation to stage and treatment]. | twenty patients with various stages of ra were examined. they included: 1) 7 cases in steinbroker stage 1 (onset); 2) 13 cases in steinbroker stage 2-3 (chronic). the group was divided into 16 treated and 4 untreated cases. monoclonal antibodies were used to assay t3, t4, t8 and t4/t8 ratio and the results were compared with those in a control group. the results showed a t8 deficit and a consequent change in the t4/t8 ratio in untreated subjects with "onset" ra. the immune situation of the chron ... | 1988 | 3258972 |
| clinical, hematologic, and immunologic cross-sectional evaluation of individuals exposed to human immunodeficiency virus type-2 (hiv-2). | we studied the clinical status and certain hematologic and immunologic parameters in healthy prostitutes from dakar, senegal who were seropositive for antibodies to human immunodeficiency virus type-2 (hiv-2). generalized lymphadenopathy and clinical signs or symptoms similar to those which are seen with human immunodeficiency virus type-1 (hiv-1) infection were not present. comparison to seronegative prostitutes and minor surgery control patients were made and significant elevations were seen i ... | 1988 | 3259142 |
| human immunodeficiency virus infection of cd4-bearing cells occurs by a ph-independent mechanism. | the effect of weak bases (nh4cl and amantadine) and carboxylic ionophores (monensin) on the infection of cd4 (t4) positive human cell lines by hiv-1 is examined. these reagents, which raise the ph of acidic intracellular organelles, fail to inhibit hiv-1 entry and the events leading to viral protein synthesis at concentrations inhibitory for low ph-dependent fusogenic enveloped viruses. the infectivity of vsv (hiv-1) pseudotypes is unaffected by weak bases at concentrations causing 95% plaque re ... | 1988 | 3259178 |
| a bacteriophage t4 expression cassette that functions efficiently in a wide range of gram-negative bacteria. | we have constructed a derivative of the broad-host-range vector rsf1010. this plasmid, p alpha omega, contains an expression cassette derived from bacteriophage t4 gene 32, into which we have inserted the coding sequence for the xyle enzyme (c2,3o) of the tol plasmid pwwo. the composite plasmid, p alpha xyle omega, was transferred by conjugal mobilisation into a variety of gram-negative bacteria (agrobacter, paracoccus, erwinia, pseudomonas, rhizobium and xanthomonas). high levels of c2,3o activ ... | 1988 | 3259198 |
| the thyroid in end-stage renal disease. | previous studies of patients with end-stage renal disease (esrd) indicate that the prevalence of goiter varies from 0 to 58% while that of hypothyroidism ranges from 0 to 9.5%. in addition, altered serum thyroid hormone levels are present in euthyroid patients with esrd and may be related to nonthyroidal disorders including malnutrition. to examine these issues further, 306 patients with esrd were compared to 139 hospitalized patients without renal disease (control population). goiter was presen ... | 1988 | 3259281 |
| clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus. | severe systemic lupus erythematosus affecting the kidney or central nervous system may lead to organ failure or death despite treatment with high doses of corticosteroids. to evaluate the clinical and immunologic effects of intravenous cyclophosphamide in this setting, we treated nine patients with monthly intravenous infusions of cyclophosphamide for six months. a comparison of characteristics at entry and follow-up revealed improvements (by paired t-test) in creatinine clearance (66 vs. 96 ml ... | 1988 | 3259286 |
| cytopathic effect of human immunodeficiency virus in t4 cells is linked to the last stage of virus infection. | a principal feature of acquired immunodeficiency syndrome is depletion of t4 lymphocytes, which is partly due to a direct cytopathic effect of the virus. both syncytial formation (viral-induced cell fusion) and premature cell death have been cited as the major cause for this phenomenon. by kinetic analysis of cell proliferation and cell lysis we show that the cytopathic effect correlates chiefly with virus production from infected cells, including giant syncytial cells. most t4 cells were, at le ... | 1988 | 3259321 |
| iodothyronines in human bile. | bile was collected from 7 patients after cholecystectomy with routine t-tube drainage of bile duct postoperatively. in all patients reported, the total volume of bile collected was more than 500 ml which was considered to be close to the volume of bile excreted by the liver during the 24 h collection period. the excretion of total thyroxine (t4), triiodothyronines (t3 and rt3) and diiodothyronines (3,3'-t2, 3,5-t2 and 3'.5'-t2) was estimated with the aid of specific radioimmunoassay described pr ... | 1988 | 3259503 |
| does immunodeficiency in uremic patients promote dialysis-related amyloidosis? | the present study was undertaken to evaluate the immune function of 5 hemodialysis patients with dialysis-related amyloidosis as compared to 6 without, both groups having a dialytic age from 7 to 21 years, and 5 healthy controls. we investigated serum levels of immunoglobulins (igg, iga, igm), made skin tests and measured peripheral lymphocyte subsets using monoclonal antibodies. 1) the absolute numbers of t3, t4 and t8 cells were significantly lower in hemodialysis patients than controls and t3 ... | 1988 | 3259551 |
| the relationship of circulating iga to cellular immunity in head and neck cancer patients. | the relationship of circulating iga titers and multiple parameters of cell-mediated immunity was examined in 97 patients with head and neck cancer. in 26% of the patients, iga titers were above one standard deviation of controls, with highest levels noted in patients with advanced disease. in 40 patients for whom multiple immune parameters were tested in vitro, increasing concentrations of iga were associated with an enhanced immunologic helper state defined by a generalized hypergammaglobulinem ... | 1988 | 3259661 |
| b-cell activation in hiv infection: relationship of spontaneous immunoglobulin secretion to various immunological parameters. | peripheral blood mononuclear cells from hiv-infected individuals spontaneously secrete elevated levels of igg, igm and igd. this increased level of synthesis and secretion is similar in hiv-infected subjects with no or few symptoms, in arc patients and in aids patients. thus, abnormal b-cell activation is characteristic of patients with mild as well as severe manifestations of hiv infection. the level of spontaneous cellular secretion of igg, igm and igd correlates with serum levels of these iso ... | 1988 | 3260155 |
| immunosuppression with monoclonal antibodies in multiple sclerosis. | we have studied the effects of various monoclonal antibody (mab) infusions in patients with chronic progressive multiple sclerosis in the hope of developing an immunologically specific, nontoxic form of therapy for this disease. the immunologic responses to anti-t12, anti-t4, and anti-t11 mab infusions were assessed in subjects with chronic progressive multiple sclerosis as part of phase i clinical studies. it was found that in vivo anti-t-cell mab infusions specifically suppress in vitro measur ... | 1988 | 3260356 |
| effects of piroxicam and d-penicillamine on t lymphocyte subpopulations, natural killer cells and rheumatoid factor production in rheumatoid arthritis. | the effects of piroxicam and d-penicillamine on t lymphocytes, nk cell activity and rheumatoid factor production as well as clinical parameters were studied in patients with rheumatoid arthritis. the level of total rheumatoid factor fell during treatment with d-penicillamine (p less than 0.02) and there was a positive correlation (k greater than 0.50, p less than 0.05) between this fall in rheumatoid factor and the improvement of several clinical activity parameters. no significant change was ob ... | 1988 | 3260400 |
| [t8-positive lymphocytes in inflammatory infiltrates of the vascular wall in nonspecific aortoarteritis]. | artery specimens obtained during surgical manipulations from 11 patients suffering from nonspecific aortoarteritis (naa) were studied immunohistochemically for t4, t8-positive lymphocytes, lfa-1-positive lymphocytes, basal membrane (bm) proteins: laminin and type iv collagen. t8-positive and lfa-1-positive cells were shown to be predominant in the sites of injury. the results obtained point out to the presence of cytotoxic cells in the affected arteries. the targets for such cytotoxic cells are ... | 1988 | 3260520 |
| pediatric acquired immunodeficiency syndrome-related complex: clinical and immunologic features. | the long term clinical outcome for infants and children with the pediatric acquired immunodeficiency syndrome-related complex is unknown. this report describes our experience with 14 patients with acquired immunodeficiency syndrome-related complex who have been followed for 11 to 71 months since the onset of their symptoms. the most frequent clinical features at presentation were persistent generalized lymphadenopathy (14 of 14), hepatosplenomegaly (11 of 14) and a history of recurrent otitis me ... | 1988 | 3260667 |
| syngeneic transplantation of thyroid tissue encapsulated in a cellulose sulphate membrane. | a new, simple encapsulation method, the precipitation of a polyelectrolyte complex membrane of cellulose sulphate and poly(dimethyldiallylammoniumchloride) was investigated in syngeneic thyroid transplantation. half a thyroid gland was placed beneath the kidney capsule either after being encapsulated or as a non-encapsulated control graft. in normo-thyroid as well as hypothyroid recipients, the grafted tissue was viable for up to 12 weeks. furthermore, the hypothyroid state, which was characteri ... | 1988 | 3260704 |