Publications

hormonal studies in patients with slipped capital femoral epiphysis without evidence of endocrinopathy.	in a prospective study, plasma levels of t3, t4, thyroid stimulating hormone (tsh), cortisol, testosterone, growth hormone, and somatomedin-c were tested in 20 consecutive adolescent patients with slipped capital femoral epiphysis (scfe) in an effort to identify any occult endocrinopathy. all patients had the clinical diagnosis of scfe confirmed on radiographs. the patients were examined by the pediatric endocrinology service and were without clinical evidence of an endocrinopathy. of 140 hormon ...	1988	3170732
clone size distributions of mutations induced by ethyl methanesulfonate in bacteriophage t4.	size distributions of mutant clones can reveal important aspects of the mutation process. previously published data on mutant clones induced by ethyl methanesulfonate (ems) in bacteriophage t4 generated a distribution that was essentially flat, implying a mutagenic mechanism involving only rare mispairing by reacted bases. here, methods for estimating the spontaneous component of such a distribution are used to generate a corrected distribution. the corrected distribution is strongly peaked, imp ...	1988	3172207
deletion formation in bacteriophage t4.	we have manipulated the dispensable region of the riib gene of bacteriophage t4 in order to study the generation of deletions involving direct repeats. we show that recombination between different parental chromosomes is one source of the deletions we have studied. we have also investigated the effects of structure, base composition and distance on deletion formation. we demonstrate that the potential to form structure in single-stranded dna has variable effects on the frequency of deletion form ...	1988	3172217
preliminary crystallographic study of pyrimidine dimer-specific excision-repair enzyme from bacteriophage t4.	bacteriophage t4 endonuclease v, which is an excision-repair enzyme specific to pyrimidine dimers within dna, has been crystallized from polyethylene glycol 4000 solution by a vapour diffusion technique. the unit cell is monoclinic, space group p2(1), with unit cell parameters: a = 41.4 a, b = 40.1 a, c = 37.5 a, beta = 90.01 degrees. the unit cell contains two 16,000 mr molecules. the crystals diffract x-rays beyond 2.3 a resolution and are suitable for structural analysis at high resolution.	1988	3172233
amino acid changes coded by bacteriophage t4 dna polymerase mutator mutants. relating structure to function.	previous studies on the selection of bacteriophage t4 mutator mutants have been extended and a method to regulate the mutator activity of dna polymerase mutator strains has been developed. the nucleotide changes of 17 bacteriophage t4 dna polymerase mutations that confer a mutator phenotype and the nucleotide substitutions of several other t4 dna polymerase mutations have been determined. the most striking observation is that the distribution of dna polymerase mutator mutations is not random; al ...	1988	3172235
effects of rose bengal on serum levels of thyroid hormones and thyroid peroxidase activity in male mice.	the thyrotoxic effect of rose bengal (rb) (4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; food red no. 105) was examined in male (c57bl/6n x c3h/n) f1 mice. they were given drinking-water containing rb at levels of 0 (control), 0.125 and 0.250% for 2 weeks. the effect resulted in decreases in serum levels of 3,5,3'-triiodothyronine (t3) and thyroxine (t4), and slight increases in serum 3,3',5'-triiodothyronine (rt3) levels and thyroid weight, but no difference in the values ...	1988	3172283
influence of l-thyroxine on cardiac function in athyreotic thyroid cancer patients--an echophonocardiographic study.	we have assessed left ventricular performance in twelve athyreotic patients by echophonocardiography during and after their follow-up investigations. patients were investigated after 4 weeks without and after 2 as well as 4 weeks of therapy with 150-200 micrograms l-thyroxine (l-t4). at the end of 4 weeks withdrawal of l-t4 patients were severely hypothyroid in terms of t4 and thyrotropin (tsh) serum levels as well as total cholesterol plasma levels. in comparison to values obtained in 12 age an ...	1988	3172681
thyroxine (t4) and triiodothyronine (t3) levels in the fischer 344 inbred rat.	plasma levels of t3 and t4 were measured in male and female fischer 344 (f344/cr1) inbred rats aged 10, 17, 30, 56, 80 and 106 weeks in order to document the hormone profile of this strain of rat. in general, levels of t4 were higher in males than in females. levels of t3 were lower in females for the first 17 weeks, similar for rats of age 30 weeks, and thereafter higher in the females than the males. t4 concentration decline was age-associated in both sexes. t3 levels declined in the males onl ...	1988	3172710
status of radiation treatment of prostate cancer at stanford university.	over 900 patients have been treated with radiation therapy in the 30-year stanford prostate study. overall survival, i.e., scoring death due to all causes, was 45%, 35%, 33%, 20%, and 10% for stanford stages t0, t1, t2, t3, and t4 (nominal stages a, b1, b2, c) at 15 years; lymph node status was unknown. disease-specific survival at 15 years was 85%, 64%, 45%, 33%, and 15%, respectively, for the same patients. in 141 patients with restricted nodular disease (lymph node status unknown) equal to or ...	1988	3173503
radiation therapy for localized prostate carcinoma: experience at the massachusetts general hospital (1973-1981).	the success following irradiation in 370 patients with clinically localized prostate carcinoma was measured by overall patient survival as well as the cumulative incidence with time of treated patients who developed either local tumor regrowth or progression with distant metastases. with a minimum follow-up of 5 years in living patients, we evaluated the cumulative frequency curves using both univariate and multivariate (cox) analyses. overall patient survival and probability of progression with ...	1988	3173505
post-herpetic neuralgia: post-mortem analysis of a case.	the morphological and biochemical substrates of the severe pain in post-herpetic neuralgia (phn) are unclear. this report is an autopsy study of a 67-year-old male with severe phn during the last 5 years of his life over the right t7-8 dermatomes. the dorsal horn of the thoracic spinal cord of the affected side was atrophic from t4 to t8, with loss of both myelin and axons. despite this, only the t8 ganglion was affected by fibrosis and cell loss and only the nerve roots at that level appeared a ...	1988	3174152
calcified thoracic disc with herniation of the nucleus pulposus in a child.	a twelve year old boy presented with acute cervical and interscapular pain, torticollis and low grade fever. the neurological examination was normal. roentgenograms showed calcification of the t3-t4 disc and posterior herniation of the nucleus pulposus was demonstrated by computed tomography. a rapid and dramatic amelioration of the symptoms was produced by treatment with a non-steroidal anti-inflammatory drug. intervertebral disc calcification in childhood is an uncommon and usually benign cond ...	1988	3174531
combination therapy with microwave coagulation and intracavitary irradiation for bladder cancer. technique and preliminary clinical results.	twenty-five patients with transitional cell carcinoma of the bladder have been treated with combined therapy consisting of microwave regional coagulation and intracavitary irradiation. a remote-controlled after-loading system was utilized for the radiation therapy. the follow-up period ranged from 6 to 19 months with an average of 11.4 months. tumor stages were tis (n = 2), ta or t1 (n = 17), t2 (n = 2), t3 (n = 3) and t4 (n = 1), and grades were g1 (n = 10), g2 (n = 11) and g3 (n = 4). in 23 pa ...	1988	3176200
3,3',5'-triiodothyronine inhibits ontogenetic development of iodothyronine-5'-deiodinase in the liver of the neonatal mouse.	to elucidate the effect of rt3 on iodothyronine-5'-deiodinating activity (i-5'-da) in the liver of neonatal mice, rt3 was injected sc on the 5-8th day after birth and i-5'-da in the liver was determined. a single injection of rt3 (0.01-1 microgram/g) inhibited the ontogenetically developing i-5'-da in a dose- and time-dependent manner. the inhibitory effect was reversible and specific for i-5'-da. lineweaver-burk analysis revealed that the time- and dose-dependent decrease in the enzyme activity ...	1988	3176813
[alteration of t4 deiodination in vitro in the brain of rats with nonthyroidal diseases].		1988	3176820
[elevated biliary excretion of t4--however, not of t3--in rats with nonthyroidal diseases (nti)].		1988	3176822
maternal-fetal thyroid hormone relationships and the fetal brain.	thyroid hormones are transferred from the mother to the fetus. thus, despite the deiodinating enzymes of the placenta (26), some t4 and t3 is transferred, both before and after onset of fetal thyroid function, at least in those cases where fetal thyroid function is impaired. it is also possible that transfer occurs under normal conditions. maternal to fetal transfer of t3 and t4 is partially limited. but it might be enough to mitigate severe fetal t4 and t3 deficiencies. however, the mitigating ...	1988	3176827
lymphocytes subclasses and function in patients with optic neuritis in childhood with special reference to multiple sclerosis.	ten patients with childhood optic neuritis (5 with a single attack of on and 5 with later ms) were studied at various stages of the disease. lymphocyte count and function were analysed in the peripheral blood of all patients, 3 repeatedly, and in one they were also analysed in the csf. t-lymphocytes counts were normal in all but 2 ms cases who had high counts. in acute stages the t4/t8 ratio were high in 1/3 determinations, in recovery low in 2/2 determinations, and in stable stages normal in 6/ ...	1988	3176883
cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear t3 receptors.	cold exposure induces a rapid increase in uncoupling protein (ucp) concentration in the brown adipose tissue (bat) of euthyroid, but not hypothyroid, rats. to normalize this response with exogenous 3,5,3'-triiodothyronine (t3), it is necessary to cause systemic hyperthyroidism. in contrast, the same result can be obtained with just replacement doses of thyroxine (t4) and, in euthyroid rats, the normal response of ucp to cold occurs without hyperthyroid plasma t3 levels. consequently, we explored ...	1988	3177636
effects of 10- to 12-day treatment with l-thyroxine in rats with myocardial infarction.	the effects of treatment with l-thyroxine (t4) for 10-12 days on left ventricular (lv) function and myosin isoenzyme content in rats with lv dysfunction after myocardial infarction were studied. electrocardiogram (ecg) criteria were used to select animals with large myocardial infarctions. these animals were divided into six groups: control and five treatment groups that received daily subcutaneous injections of t4 (1.5, 3, 6, 10, or 15 micrograms/100 g body wt) for 10-12 days. intravascular pre ...	1988	3177671
lack of correlation between peroxidase activity and iodothyronine levels in human and murine thyroid tissues.	since thyroid peroxidase (tpo) is essential in thyroid hormone biosynthesis, we evaluated whether a correlation exists between tpo activity and iodothyronine stores in human thyroid tissues from nodular goiters with scintigraphically "cold" (n = 10) or "hot" (n = 7) nodules, diffuse toxic goiters (n = 6), and in normal rat thyroids (n = 18). t4, t3 and rt3 were significantly correlated (rs greater than 0.84, p less than 0.001) in human thyroid tissues, although no correlation between tpo activit ...	1988	3179567
relationship between dietary tyrosine and plasma cholesterol in the rat.	the present study was undertaken to measure the effects of dietary tyrosine added to fish protein and peanut meal on plasma cholesterol and plasma thyroid hormone levels in the rat. these dietary proteins were chosen because they contain similar amounts of tyrosine but release it at different rates during enzymatic hydrolysis. casein was chosen as the reference protein. supplementation was used to obtain tyrosine levels similar to that of casein. male sprague-dawley rats were fed cholesterol-enr ...	1988	3179835
a possible effect of heme on the fate of dna ligase activity extracted from differentiating mouse erythroleukemia cells.	when mouse erythroleukemia (mel) cells were induced to differentiate by growth in the presence of dimethyl sulfoxide, hexamethylene bisacetamide (hmba), or hemin, the apparent activity of dna ligase extractable from inducer-treated cells decreased 70 to 80% when compared to untreated cells. earlier work had indicated that these changes did not occur in a differentiation-resistant mel cell variant and suggested that the decrease in the level of dna ligase activity might be related to the differen ...	1988	3180046
atypical presentation of hodgkin's disease in a patient at risk for the acquired immunodeficiency syndrome.	hodgkin's disease (hd) has been reported in association with the acquired immunodeficiency syndrome (aids) only occasionally, and these patients seemed to have aggressive unusual hd. we report an additional case of hd in a 50-year-old homosexual man with a marked change of his clinical course after the development of seropositivity to human immunodeficiency virus (hiv). in 1978, hd stage iiia, nodular sclerosing type, was diagnosed and treated with splenectomy and total nodal radiotherapy, which ...	1988	3180129
immunohistological characterization of a ewing's sarcoma case.	the histogenesis of ewing's sarcoma (es) remains uncertain. mesenchymal and neuroectodermal origins were the most recent hypotheses. in an attempt to test these two hypotheses, frozen sections of an es with the chromosomal translocation t(11;22) have been studied using a panel of antibodies directed against monocytes/macrophages cell surface antigens (leu m1, leu m2, leu m3, and mo1), and against neural components (nse, s-100, t4, and hnk-1). none of these antigens were detected. positive reacti ...	1988	3180134
evaluation of four commercially available assays for free thyroxin.	we assessed two two-step and two analog assays for measuring free thyroxin (ft4) in serum: clinical assays' "gammacoat free/total t4" (ca), vitek's "kineticount phase ii free t4" (vtk), diagnostic products corporation's "coat-a-count free t4" (dpc) kit (june 1987 version), and amersham's "amerlex-m free t4" (amx). the vtk assay is automated except for the initial pipetting step. interassay results correlated well except for samples with abnormal serum albumin concentrations. ft4 values for hypoa ...	1988	3180426
performance of the simultrac free t4/tsh assay during pregnancy and treatment with amiodarone.		1988	3180453
hbv, hdv and hiv infections in 242 drug addicts: two-year follow-up.	of 242 north italian heroin addicts, 24 (9.9%) were hbsag positive. hbeag was positive in two of them (8.3%), anti-hbe in 16 (66.6%) and anti-hdv in 21 (87.5%). of the 218 hbsag negative, 182 (83.5%) had anti-hbc, 72 (33.0%) anti-hbe and 97 (44.5%) anti-hbs. one-hundred-eighty-five drug addicts were anti-hiv positive (76.4%); 77 of these (41.6%) were asymptomatic, 93 (50.3%) had pgl and 15 (8.1%) arc. t4+ cell count was significantly lower in subjects with arc as was t4+/t8+ ratio in subjects wi ...	1988	3181382
effect of myo-inositol and t3 on myocardial lipids and cardiac function in streptozocin-induced diabetic rats.	numerous experimental studies have implied a link between diabetes-induced abnormal lipid buildup in the myocardium and the development of cardiomyopathy. because the diabetic state in rats is associated with lowered t3 (triiodothyronine) and t4 levels and because diabetic patients excrete large amounts of myo-inositol, a lipotropic agent, we investigated the effects of myo-inositol and t3 on the elevated myocardial lipid levels and depressed cardiac performance of streptozocin (55 mg/kg i.v.)-i ...	1988	3181644
decline of t3 and elevation in reverse t3 induced by hyperglucagonemia: changes in thyroid hormone metabolism, not altered release of thyroid hormones.	recently we reported that hyperglucagonemia induced by glucagon infusion causes a decline in serum triiodothyronine (t3) and a rise in reverse t3 (rt3) in euthyroid healthy volunteers. these changes in t3 and rt3 levels were attributed to altered t4 metabolism in peripheral tissues. however, the contribution of altered release of thyroid hormones by the thyroid gland could not be excluded. since the release of thyroid hormones is suppressed by exogenous administration of l-thyroxine (l-t4) in ap ...	1988	3181870
cancer of the supraglottic larynx treated by radiotherapy exclusively.	seventy-six cases of squamous cell carcinoma of the supraglottic larynx treated by radiotherapy exclusively and followed for at least 3 years are reported. high doses, close to the maximum tolerable, were used with the shrinking field technique with no attempt at prophylactic whole neck irradiation. t1 and t2 cases represented 40% of the whole group and 40% of the patients presented clinically positive neck disease. this latter group had a significantly lower cure rate (42.8%) than the n0 patien ...	1988	3182324
preliminary results of treatment of invasive bladder carcinoma with radiotherapy and cisplatin.	from october 1985 to february 1988, 41 patients with invasive bladder cancers were treated with transurethral resection (tur) and radiotherapy with simultaneous cisplatin chemotherapy at the university hospital in erlangen. radiotherapy was performed as primary treatment in case of macroscopic residual tumor after tur (n = 22) or as adjuvant treatment in patients with macroscopically complete transurethral resection (n = 19). age ranged from 44 to 77 years. radiotherapy was given in daily fracti ...	1988	3182327
nasopharyngeal carcinoma in saudi arabia: a retrospective study of 166 cases treated with curative intent.	a retrospective review was performed of the medical records of 166 adult patients with biopsy-proven carcinomas of the nasopharynx treated with curative intent at king faisal specialist hospital and research center, riyadh, saudi arabia. all patients were treated between june 1975 and december 1985 using megavoltage therapy equipment. most patients presented with advanced nodal disease: 23 patients (13.9%) were n0, 16 patients (9.6%) were n1, 29 patients (17.5%) were n2, and 98 patients (59%) we ...	1988	3182344
normal free thyroxine in critical nonthyroidal illnesses measured by ultrafiltration of undiluted serum and equilibrium dialysis.	considerable controversy exists concerning the assessment of thyroidal state in critically ill patients with decreased serum t4 and t3 concentrations, in part because serum free t4 values are often low in such patients no matter what method of measurement is used. we developed an ultrafiltration method to measure free t4 and free t3 in undiluted serum and compared the results with those obtained using a standard equilibrium dialysis method to measure free t4 and t3. in 30 consecutive intensive c ...	1988	3182956
hyperthyroidism due to selective pituitary resistance to thyroid hormones in a 15-month-old boy: efficacy of d-thyroxine therapy.	a 15-month-old boy had clinical features of hyperthyroidism. in spite of elevated serum thyroid hormone levels (mean serum t4, 230 nmol/l; t3, 4.2 nmol/l), serum tsh levels ranged between 3.3-5.6 mu/l and rose to 35.4 mu/l after trh stimulation. there was no abnormal serum thyroid hormone binding or any evidence of a pituitary tumor. the boy was treated with carbimazole for 6 months and became euthyroid. however, his thyroid size enlarged, and serum tsh rose to 45 mu/l. in an attempt to suppress ...	1988	3182960
the acute effects of human growth hormone administration on thyroid function in normal men.	gh replacement therapy may lead to alterations in serum tsh and/or thyroid hormone values in gh-deficient patients, but there is no consensus on the explanation for these changes. we examined the effect of gh administration (0.125 mg, sc, daily for 4 days) on thyroid function in 20 normal men. serum t4 levels decreased by 8%, and serum free t4 index values decreased by 5%. in contrast, serum t3 levels increased by 21%; serum rt3 did not change. these changes were accompanied by a 54% decrease in ...	1988	3182961
a subchronic inhalation study with unleaded petrol in rats.	the effect of intermittent 2 months' exposure to 2 g/m3 unleaded petrol on the hypothalamo-pituitary-thyroid-adrenal system was evaluated by measuring hypothalamic noradrenaline (na), serum corticosterone (cs), thyroxine (t4) and adrenal catecholamine (ca) levels in male rats. serum cs and adrenal ca were increased and hypothalamic na was decreased by exposure. no changes were observed in serum t4. exposure induced an increase in spleen, kidney, liver and lung weights; weights of adrenals and hy ...	1988	3183289
furosemide, fenclofenac, diclofenac, mefenamic acid and meclofenamic acid inhibit specific t3 binding in isolated rat hepatic nuclei.	previous studies with phenytoin (dph) show that this inhibitor of thyroid hormone binding to plasma proteins also interacts with specific nuclear t3 binding sites. in order to further define the nuclear effects of drugs that inhibit plasma protein binding of thyroid hormones, we assessed furosemide and a number of non-steroidal antiinflammatory drugs using isolated rat liver nuclei. the effects were compared with those of dph, ipodate and amiodarone. the t3 binding site in isolated nuclei (ka 1. ...	1988	3183298
detection and treatment of lung metastases of differentiated thyroid carcinoma in patients with normal chest x-rays.	lung metastases were demonstrated by total-body 131i scans in 23 patients with differentiated thyroid carcinoma, at a time when chest x-ray was normal. this total-body 131i scan was performed after the administration of 2 mci (in 11 patients) or 100 mci (in 12 patients). overall uptake of 131i in lungs was less than 1% of the administered dose in 11 patients. all patients were treated with radioiodine. no lung uptake was found in 20 patients at the last 100 mci post-therapy scan. among them, tg ...	1988	3183748
serum thyroxine and triiodothyronine radioimmunoassay values in the normal ferret.	the european ferret, mustela putorius furo, has become increasingly popular as an animal model in biomedical research. however, certain important normal clinical data have not been established for the ferret. in this study, serum thyroxine (t4) and 3,3',5-triiodothyronine (t3) values were obtained from ferrets by the use of commercial radioimmunoassays. sera from 44 animals, 31 males (27 intact and 4 castrated) and 13 females (10 intact and 3 spayed) were assayed. serum t4 values ranged from 1.0 ...	1988	3184856
[t4-dna ligase: substrate properties of synthetic dna-duplexes with structural anomalies].	structural defects, affecting t4 dna ligase function, were revealed with the help of synthetic dna duplexes, containing modifications at single nick. changes of configuration at c2' and c3' atoms of furanose in the acceptor terminus lead to total blocking of the nick sealing activity of t4 dna ligase. on the contrary, substitution of 3'-terminal deoxyribonucleotide for ribonucleotide doesn't affect the enzyme's action. the duplex looses all of it's substrate activity if the next from the nick g. ...	1988	3185524
binding of cisplatin to specific sequences of human dna in vitro.	cisplatin was reacted with a 184-base-pair sequence, exon 3, of human hprt dna in vitro. the binding sites were mapped by a primer extension method with t4 dna polymerase and radioactive dctp. binding sites of cisplatin were indicated by the lengths of synthesized polynucleotides as determined by gel electrophoresis. neighboring gg dinucleotides were highly preferred sites of binding by cisplatin, while less binding was noted to gxg, ga, aaa, and gxa. analysis by densitometry revealed a 5-fold d ...	1988	3185585
bacteriophage t4 gene 25.		1988	3186452
determination of thyroxine release in vivo: a simple, specific and sensitive method in mice.	when thyroid hormone secretion in vivo was studied by the release of 125i from thyroid to blood after tsh in mice preloaded with the isotope, only 54.4 +/- 2.0% (+/- se) of plasma 125i was butanol extractable, indicating low specificity for thyroid hormones. to improve specificity plasma 125i was bound to anti-t4 rabbit antibodies and precipitated with goat antirabbit serum. the intraassay coefficient of variation was 2.5%, and anti-t4 bound radioactivity correlated well with that extractable wi ...	1988	3186626
photochemical crosslinking of bacteriophage t4 single-stranded dna-binding protein (gp32) to oligo-p(dt)8: identification of phenylalanine-183 as the site of crosslinking.	using ultraviolet light, both the 33,000-dalton single-stranded dna-binding protein from t4 bacteriophage (gp32) as well as a 25,000-dalton limited trypsin cleavage product of gp32 (core gp32*) that retains high affinity for single-stranded dna can be crosslinked to an oligodeoxynucleotide, p(dt)8. after photolysis, a single tryptic peptide crosslinked to p(dt)8 was isolated by anion-exchange high-performance liquid chromatography. gas-phase sequencing of this modified peptide gave the following ...	1988	3186689
intra-arterial chemotherapy for advanced bladder cancer.	the results of prolonged intra-arterial chemotherapy in 61 patients with locally advanced bladder cancer (t3-t4) are discussed. regional internal iliac artery infusion of chemotherapeutic agents was done daily for 5 or 7 days at a rate of 1 to 3 ml/h over an 18-20-h period. the total dosages of each course were 60-120 mg/m2 adriamycin, 2.5-3.5 g/m2 5-fluorouracil (5-fu), 20-40 mg/m2 methotrexate or 30-50 mg/m2 cisplatin. at 3 to 4 weeks after the completion of infusional chemotherapy the results ...	1988	3188244
[mail handling: a possible cause of error in the non-selective screening for congenital hypothyroidism].	remittance by mail of blood samples and subsequent time of permanency in mail boxes are not supposed to be best thermic conditions for dried blood samples in paper used for neonatal screening. with the idea of checking if temperatures variations can altered or not the content of tsh and t4, some samples of known concentrations of tsh and t4 has been heated to different temperatures between less than -40 degrees c and 100 degrees c during weekly periods. at such temperatures between less than -40 ...	1988	3190007
[the effect of ssb-protein from ehrlich ascites carcinoma cells on activity of various enzymes of dna replication and repair].	the effect of a single-stranded dna-binding protein (ssb-protein) form ehrlich ascites tumour cells (eat) on the activity of homologous purified dna-polymerases alpha and beta, dna-replicase, primase and dna-polymerases from phage t4 and bacillus stearothermophillus was studied. it was shown that the ssb-protein caused a 1.5-2.5-fold stimulation of the dna-polymerase alpha activity on different templates (e.g., denaturated and activated dna, poly(da). the degree of stimulation depended on the te ...	1988	3191193
variations in the percentages of lymphocyte subtypes during the menstrual cycle in women.	in view of the well-known circadian variations in lymphocytes and their subtypes, we decided to study the possible variations in the proportions of these cells during the menstrual cycle in women. in order to do this, lymphocyte populations were determined during 3 successive cycles on d1, d13, d14, d15 and d25 in 6 women with 28-day cycles who were not on oral contraceptives. in each of these women, we then compared the percentages of lymphocyte subtypes during the different periods of the cycl ...	1988	3191205
stimulation of alkaline phosphatase activity by thyroid hormone in mouse osteoblast-like cells (mc3t3-e1): a possible mechanism of hyperalkaline phosphatasia in hyperthyroidism.	in order to elucidate the mechanism of increased alkaline phosphatase (ai-p) activity of bone origin in serum of patients with hyperthyroidism, the effects of thyroid hormone on mouse osteoblast-like cells (mc3t3-e1) were studied in vitro. triiodo-l-thyronine (t3) and thyroxine (t4) produced a dose-dependent increase in ai-p activity in the cells at minimum concentrations of 10(-10)m t3 (free t3, 5 x 10(-12) m) and 10(-8) m t4 (free t4, 8 x 10(-11) m), respectively. scatchard analysis revealed t ...	1988	3191290
analysis of the possibility that transurethral resection promotes metastasis in prostate cancer.	the issue of transurethral resection (turp) in patients with known prostatic adenocarcinoma is a current clinical controversy. data have accumulated to associate this procedure with an adverse risk of distant spread and death for a defined subset of patients with moderate and poorly differentiated, t3 and t4 (stage c) tumors. review of available literature demonstrates that examination of this subset is incomplete in studies that do not find an adverse prognosis. the reason for the association o ...	1988	3191464
fasting induces a decrease in serum thyroglobulin in normal subjects.	fasting decreases serum t3 concentrations by reducing peripheral conversion of t4 to t3. whether it affects tsh and thyroid secretion is controversial. thyroglobulin (tg) is a secretory product of the thyroid gland. to determine if fasting might alter thyroid secretion, we measured serum tg concentrations during and after a 4-day fast in seven normal subjects and examined its correlation with serum tsh, t4, and t3 concentrations. serum tsh concentrations significantly decreased from a mean prefa ...	1988	3192683
the anabolic actions of growth hormone and thyroxine on protein metabolism in snell dwarf and normal mice.	the individual effects of gh and thyroxine (t4) on protein metabolism were determined in dwarf and normal mice in vivo. the hormone deficiencies of dwarf mice (low serum concentrations of gh and t4) resulted in decreased protein synthesis rates in skeletal muscle and liver, but no difference in synthesis rates in heart. the efficiency of synthesis (g protein/g rna per day; krna) was lower in all three tissues in dwarf compared with normal mice, but effects on rna concentration were not consisten ...	1988	3193047
[clinical significance of the measurements of serum free thyroxine and free triiodothyronine concentrations--evaluation using dpc free t4 and free t3 kits].		1988	3193656
movable finite automata (mfa) models for biological systems. i: bacteriophage assembly and operation.	a new class of models, called movable finite automata (mfa) models, is introduced. mfa models are physically realistic, but still share some of the features of cellular automata that make the latter easy to handle mathematically and computationally. they are found to be quite versatile in modeling the self-organization of biological systems. their use in simulating the interaction of protein molecules in the self-assembly and operation of the t4 bacteriophage is described. the results of these s ...	1988	3193776
amiodarone alters thyroxine transfer and distribution in humans.	previous studies indicate that increased serum total and free t4 levels may be secondary to a proportionally greater decrease in serum t4 clearance rates than in production rates after short-term amiodarone administration, to increased t4 production rates as well as reduced serum clearance rates in selective hyperthyroxinemia without overt hyperthyroidism following chronic amiodarone administration, and to a relatively greater increase in t4 production rates than in clearance rates in classical ...	1988	3193898
nucleotide and deduced amino acid sequence of bacteriophage t4 gene wac.		1988	3194206
treatment of genomic dna with t4 dna ligase improves southern blot analysis.		1988	3194221
analysis of ovine peripheral blood lymphocyte subsets following ficoll-hypaque separation or erythrocyte lysis.	peripheral blood lymphocyte subsets were analysed with the aid of monoclonal antibodies and flow microfluorometry following separation by either the ficoll-hypaque method or erythrocyte lysis of the buffy coat. the percentage of lymphocytes labelled by the monoclonal antibodies sbu-t1, sbu-t4 and sbu-t8 were significantly greater (p less than 0.05) in samples obtained by erythrocyte lysis. in contrast, a lower percentage of lymphocytes was labelled by sbu-t6 following erythrocyte lysis (p less t ...	1988	3194596
erythromycin-resistant beta-hemolytic streptococci group a in göteborg, sweden.	a total of 21 erythromycin-resistant strains were found among 355 (5.9%) beta-hemolytic streptococci group a isolated in göteborg during spring of 1987. t-typing showed 17 to be t12, 1 t4 and 3 nontypable. spread of resistant strains could be demonstrated within 2 families and 1 day-care-center. monitoring of erythromycin resistance among beta-hemolytic streptococci is advocated.	1988	3194710
hypothyroidism presenting with respiratory muscle weakness.	a 58-yr-old woman presented with recurrent chest infections, breathlessness, and orthopnea. she complained of nonspecific tiredness and aching limbs. a chest radiograph showed an elevated right hemidiaphragm. thyroid function tests showed her to be severely hypothyroid (t4 = 23 nmol/l; tsh greater than 50 mu/l). measurement of maximal respiratory mouth pressures (expiratory: 50 cm h2o, normal, 94 +/- 33; inspiratory: 15 cm h2o, normal, 71 +/- 27) suggested global respiratory muscle weakness. sev ...	1988	3195839
tissue-specific alterations of de novo fatty acid synthesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)-treated rats.	de novo fatty acid synthesis was determined by the 3h2o method in numerous tissues and organs of tcdd-treated (125 micrograms/kg), pair-fed and free-fed male sprague-dawley rats to investigate if this important pathway of intermediary metabolism is altered by tcdd. of the 12 tissues and organs examined, liver showed an increased, and interscapular brown adipose tissue (ibat) a decreased de novo fatty acid synthesis when comparing tcdd-treated to pair-fed or free-fed control rats. de novo fatty a ...	1988	3196149
susceptibility of rocky mountain bighorn sheep and domestic sheep to pneumonia induced by bighorn and domestic livestock strains of pasteurella haemolytica.	bighorn sheep were inoculated intratracheally with suspensions of nonhemolytic pasteurella haemolytica biotype t (10(12) organisms) unique to wild bighorns, with beta-hemolytic p. haemolytica biotype t (10(12) organisms) isolated from clinically normal domestic sheep or intradermally with half a dose of a cattle vaccine containing p. haemolytica biotype a (10(5) organisms). the bighorn strain caused lobar necrotizing bronchopneumonia whereas both domestic livestock strains precipitated fatal sep ...	1988	3196974
screening for thyroid disease in the elderly. serum concentrations of thyrotropin and 3,5,3'-triiodothyronine in a representative population of 79-year-old women and men.	thyroid function in individuals from a representative population of 79-year-olds was evaluated clinically and from measurements of serum thyrotropin (tsh) and 3,5,3'-triiodothyronine (t3). high tsh concentrations (greater than or equal to 10 mu/l) were found in 16 of 320 women (5%) and 2 of 204 men (1%). signs and symptoms which traditionally are regarded as related to hypothyroidism were as common in subjects with high tsh concentration as in the remaining population and occurred in 10-50% of t ...	1988	3197053
[endocrine function and african trypanosomiasis. evaluation of 79 cases].	although the high frequency of hypogonadism was found during the sleeping sickness, the physiological properties of the gonads have been poorly studied. we reported here the exploration of the gonadotropic axis in 79 patients infected by trypanosoma brucei gambiense. it has been noted a decrease in oestradiol for 50% of women, in testosterone levels for 50% of men whereas no decrease of pituitary gonadotropins (fsh and lh) was found. the results of the gonad adenohypophyseal tests suggested that ...	1988	3197243
autoantibodies to thyroxin and triiodothyronine in the immunoglobulin g fraction of serum.	thyroid hormone antibodies (thabs)--i.e., antibodies to thyroxin (t4) and triiodothyronine (t3)--are detected rarely in human serum, where they are searched for, possibly because of a quantitatively minimal interaction between thyroid hormones (the haptens) and serum iggs (the antibodies). the weak binding could result from these facts: (a) there are already six physiological carrier proteins for thyroid hormones; (b) thabs usually account for a very small fraction of the total serum iggs; (c) t ...	1988	3197301
interference in a luminometric enzyme-labeled analog assay for free t4.		1988	3197314
pulsatile intravenous growth hormone (gh) infusion to hypophysectomized rats increases insulin-like growth factor i messenger ribonucleic acid in skeletal tissues more effectively than continuous gh infusion.	in this study we have investigated a possible functional role of the plasma pattern of gh in regulation of insulin-like growth factor i (igf-i) mrna in liver, skeletal muscle, and rib growth plate of the rat. hypophysectomized male rats given t4 and glucocorticoid replacement therapy were equipped with indwelling jugular venous cannulae attached via swivels to a multichannel pumping system programmed to deliver human gh in a continuous or pulsatile (one pulse per 3 h) pattern for 5 days. at the ...	1988	3197637
assessment of the relationship between serum thyroid hormone levels and peripheral metabolism in patients with anorexia nervosa.	it has been observed that basal and/or trh-stimulated serum tsh levels occasionally conflict with the actual values of circulating thyroid hormones in patients with anorexia nervosa. in the present study sixteen female patients with anorexia nervosa during self-induced starvation displayed clinical findings suggesting hypothyroidism, e.g., cold intolerance, constipation, bradycardia, hypothermia and hypercholesterolemia in association with decreased serum total t3 (62.8 +/- 5.2 ng/dl) and t4 (6. ...	1988	3197656
significance of serum thyrotropin and plasma dopamine concentration in the regulation of thyroid function in elderly subjects.	in our previous study, we observed a tendency towards an age-related increase in the serum thyrotropin (tsh) concentration. regulatory mechanisms of tsh secretion in elderly subjects were studied. in 43 elderly subjects, serum tsh did not correlate significantly with serum t4, t3 free t4 or rt3. further, those with increased tsh (greater than 5 mu/l, 9 subjects) did not overlap with those with low t3 (less than 0.92 nmol/1, 8 subjects). increases in serum tsh were not associated with the presenc ...	1988	3197658
evidence of hypothyroidism in the genetically epilepsy-prone rat.	a number of neurochemical and behavioral similarities exist between the genetically epilepsy-prone (gepr) rat and rats made hypothyroid at birth. these similarities include lower brain monoamine levels, audiogenic seizure susceptibility and lowered electroconvulsive shock seizure threshold. given these similarities, thyroid hormone status was examined in gepr rats. serum samples were collected from gepr-9 and non-epileptic control rats at 5, 9, 13, 16, 22, 31, 45, 60, 90, 150 and 350 days of age ...	1988	3197682
the innervation of the adrenal gland. i. the source of pre- and postganglionic nerve fibres to the rat adrenal gland.	the sympathetic innervation of the rat adrenal medulla was studied using the fluorescent tracer fast blue. labelled preganglionic cell bodies were located in the intermediolateral horn of the spinal cord at segments t1 and l1; the greatest number was found in t9. the ilp nucleus contained 95%, the ilf nucleus 4%, and the ic nucleus 1% of the total number of labelled preganglionic cells. labelled postganglionic cell bodies were found in the sympathetic ganglia at levels t4 and t12; the maximum nu ...	1988	3198482
hormonal and organ weight changes in rats exposed to simultaneous chronic effects of co and no2.	activity of the pituitary-adrenocortical, sympathico-adrenomedullary and thyroid gland systems was examined in groups of male adult rats, average weight 180 g, exposed for 2 months to a mixture of 7 mg.m-3 no2 and 32 mg.m-3 co in air and in groups of matched controls inhaling fresh air. corticosterone (b) concentrations in the serum of rats were determined by the competitive protein-binding method, noradrenaline (na) in the hypothalamus and catecholamines (ca) in suprarenals by fluorometry, thyr ...	1988	3198909
head structure of bacteriophages t2 and t4.	the length-to-width ratios of bacteriophage t2 and t4 heads and stereometric angles specifying the prolate icosahedral t2 capsid were evaluated on electron micrographs recorded from samples prepared by a variety of methods. the copy numbers of the major capsid protein, gp23*, of t2 and t4 phages were compared by quantitative gel electrophoresis. taken together, the resulting values are most compatible with triangulation numbers t = 13 and q = 21 for both t2 and t4, thus confirming the previously ...	1988	3198952
[treatment of head and neck cancer with twice-a-day fractionation].	fifty patients with locally advanced head and neck cancer were treated with twice-a-day fractionation (1.0-1.5 gy 2 times daily, 5 days per week). these patients consist of 12 cases of thyroid cancer, 23 of hypopharynx cancer, 7 of cancer of the oral cavity, 6 of oropharynx cancer and 2 of other sites. total delivered dose was 21-73 gy in 10-74 days. in respect of thyroid cancer, 2 cases of 3 with papillo-follicular carcinoma, 1 of 1 with small cell carcinoma and 3 of 8 with giant cell carcinoma ...	1988	3199514
enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles.	two different genetically engineered amino-acid substitutions designed to interact with alpha-helix dipoles in t4 lysozyme are shown to increase the thermal stability of the protein. crystallographic analyses of the mutant lysozyme structures suggest that the stabilization is due to electrostatic interaction and does not require precise hydrogen bonding between the substituted amino acid and the end of the alpha-helix.	1988	3200317
[contributions of the measurement of tsh, t4 and thyroglobulin, of 99m tc scintigraphy and of cervical ultrasonography to the early diagnosis of congenital hypothyroidism].	over 10 years, extending from 1978, 200,000 newborns of the champagne-ardennes region have been tested within the screening program for congenital hypothyroidism. congenital hypothyroidism was diagnosed in 96 infants (28 boys, 68 girls): 73 thyroid dysgenesis (50 ectopic glands and 23 undetectable thyroid tissue) and 23 thyroid dyshormonogenesis (14 permanent and 9 transient defects). our local frequency was 1/2,600, significantly higher than the french and european frequencies. there was a mark ...	1988	3200667
t4 endonuclease vii cleaves the crossover strands of holliday junction analogs.	we have formed four-arm branched dna junctions that contain no more than a single base pair of branch migratory freedom. recently, we have shown that these holliday junction analogs have twofold symmetric protection patterns in solution when probed with hydroxyl radicals: two opposite strands of one junction show extensive protection near the branch point, while the other pair of opposite strands is virtually as susceptible as a double helix. in a different junction, the hydroxyl radical protect ...	1988	3200829
phenotypical and functional analysis of bronchoalveolar lavage lymphocytes in patients with hiv infection.	the lungs of patients with acquired immunodeficiency syndrome (aids) are frequently affected by opportunistic and nonopportunistic infections and pulmonary localizations of kaposi's sarcoma. the aim of this study was to verify whether, in patients with human immunodeficiency virus (hiv) infections, immunologic pulmonary abnormalities set the stage for the lung complications. for this purpose, a phenotypic and functional characterization of lymphocytes recovered from the bronchoalveolar lavage (b ...	1988	3202512
effect of pattern of administration on the response to exogenous pituitary-derived chicken growth hormone by broiler-strain pullets.	the effect of pulsatile versus continuous intravenous administration of exogenous, pituitary-derived chicken growth hormone (cgh) on growth performance and endocrine/metabolite status of broiler-strain pullets was determined. in a first study, 8-week-old pullets, surgically prepared with intravenous catheters and maintained via a fluid swivel/spring tether/harness system, were administered cgh or vehicle (control) over a 10-min period every 90 min (i.e., 90-min pulse pattern) for 21 consecutive ...	1988	3203875
the effect of thyroxine on spontaneous thyroiditis in bb/w rats.	the effect of t4 on the incidence of lymphocytic thyroiditis and on titers of antibodies to thyroglobulin and thyroid microsomal antigen was studied in bb/w rats that are prone to develop spontaneously autoimmune thyroiditis and diabetes. thirty-three animals were separated in two groups. rats in one group had 1 mg t4 per liter of drinking water, and the other group was given no t4. after 3-4 months of therapy the t4-treated group had a reduced production of antibody to thyroglobulin (p less tha ...	1988	3203967
developmental changes in rat brain 5'-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyroidism and maternal thyroid hormones.	we have studied the ontogenesis of 5'-deiodinase (5'd) activity in rat brain during fetal life, its capacity to respond to maternal or fetal hypothyroidism, and its regulation by maternal thyroid hormones. type ii 5'd (5' d-ii) activity increases 4-fold during the period studied (17 to 22 days of gestation), mainly between days 19 and 21. fetal brain t4 concentrations increase in parallel with fetal plasma t4, whereas fetal brain t3 concentrations increase 18 times (days 17-21), six times more t ...	1988	3205610
influence of experimental hyperthyroidism on the adult rat pancreas, small intestine, and blood gastrin levels.	thyroxine modulates the ontogenic changes of animal tissues. in this study, the effects of experimental hyperthyroidism on the adult rat pancreas, small intestine, and serum gastrin were evaluated. hyperthyroidism was induced by oral feeding of thyroxine (t4) in increasing dosages (150-450 micrograms/kg body weight; 3 weeks) and controlled by measurements of the circulating hormones. the increase of thyroid hormones in blood (t4 ng/dl: thyroxine-treated rats 10.8 vs. controls 3.3; p less than 0. ...	1988	3206918
optically detected magnetic resonance study of tyrosine residues in point-mutated bacteriophage t4 lysozyme.	two spectroscopically distinct types of tyrosine (tyr) residues in triply point mutated bacteriophage t4 lysozyme, which contains no tryptophan (trp), have been detected by optical detection of triplet-state magnetic resonance (odmr) spectroscopy. their triplet states are characterized by similar e but different d values. the tyr site which exhibits the lower d value and has the red-shifted phosphorescence origin is quenched by energy transfer to trp and has d and e values comparable to previous ...	1988	3207713
comparative triplet-state properties of the three tryptophan residues in bacteriophage t4 lysozyme and in the enzyme complex with methylmercury(ii).	triplet-state energies, zero-field splittings (zfs), and total decay rate constants of the individual triplet-state sublevels of the tryptophan (trp) residues located at positions 126, 138, and 158 in bacteriophage t4 lysozyme have been determined by using low-temperature phosphorescence and optical detection of magnetic resonance spectroscopy in zero applied magnetic field. an investigation of spectral and kinetic properties of individual trp residues was facilitated by measurements on point-mu ...	1988	3207714
on the question of dna bending: two-dimensional nmr studies on d(gttttaaaac)2 in solution.	it is very well documented that the presence of an an.tn tract causes intrinsic dna bending. hagerman demonstrated that the sequence in which the an.tn tracts are joined plays a very crucial role in determining dna bending. for example, hagerman showed that the polymer with a repeat of d(ga4t4c)n greater than or equal to 10 is bent but the polymer with a repeat of d(gt4a4c)n greater than or equal to 10 is not bent [hagerman, p. j. (1986) nature (london) 326, 720-722]. earlier we have shown that ...	1988	3207719
developmental changes in erps to visual language stimuli.	erps to visual language stimuli were recorded in normal children (7-18 years) and adults from fpz, fz, cz, pz, oz, f3, f4, c3, c4, p3, p4, t3, t4, t5 and t6. an oddball paradigm was employed with letter discrimination and lexical decision tasks. n2 and p3 latencies decreased significantly with age, n2 until adolescence, p3 until adulthood. the p3 amplitude increased until 11-12 years and then decreased until adulthood. in younger children there was a large frontal negativity and posterior positi ...	1988	3207790
preferential cholinergic projections by embryonic spinal cord neurons within cocultured mouse superior cervical ganglia.	the development of preferential cholinergic projections of spinal cord neurons within superior cervical ganglia (scg) was analyzed in vitro using cocultures of scgs (e17) with organotypic explants of fetal mouse cord (e13). the cord explants consisted of: (1) dorsal vs medioventral strips or mediodorsal vs ventral strips (dissected from levels c8-t4), or (2) transverse sections cut at various levels of the neuraxis. after 4 weeks of coculture, choline acetyltransferase (chat) was assayed in indi ...	1988	3208105
3,5,3'-triiodo-l-thyronine binding sites in nuclei of human trophoblastic cells.	nuclear binding sites of t3 in human trophoblastic cells were biochemically characterized. nuclei were isolated by a combination procedure with mild homogenization of the freshly obtained trophoblastic tissue aged term gestation, centrifugations and triton x-100 treatment. the isolated nuclei were incubated with various concentrations of 125i-t3 at 20 degrees c for 3 h. the total number of t3 binding sites per nucleus was approximately 650. the apparent association constant (ka) was 6.0 x 10(9)m ...	1988	3208700
thyroid hormone metabolism in neuron-enriched primary cultures of fetal rat brain cells.	the metabolism of thyroxine (t4) by cultures of embryonic-rat brain cells grown in a chemically defined medium was studied. cells in these cultures were predominantly neurons, characterized by the developmental increase of the binding of [3h]flunitrazepam to the high-affinity (0.67 nm) benzodiazepine neuronal receptors. the cultures also contained astrocytes, characterized by immunological studies using an anti-glial fibrillary acidic protein (gfap) and by the increase in glutamine synthetase (g ...	1988	3208989
the functions of the phage t4 immunity and spackle genes in genetic exclusion.		1988	3209067
sympathetic postganglionic innervation of the cardiac coronary artery in cats.	the localization of the sympathetic postganglionic neurons innervating the cardiac coronary arteries of the cat was investigated using retrograde axonal transport with horseradish peroxidase. we found after the enzyme was applied to the main trunk of the right coronary artery, and to the main trunk and the terminal branch of the ventral descending vessels of the left coronary artery, the peroxidase-labeled sympathetic neurons were localized predominantly in the right stellate ganglia, with a few ...	1988	3209806
the effects of high iodine on the brain development of mice.	c57 mice were divided into two groups: (a): experiment group (h group). each female mouse was injected with 20 microliter iodized oil; (b): control group (n group). both groups were mated 8 days after iodized oil injection. urine iodine contents/24 h of h group was 20 times higher than that in n group 7 days after injection and 18 times higher two months later. serum t4 values were determined. brain protein, dna, body weight, motility and learning ability were measured in the progeny. the result ...	1988	3209818
the relation of serum t4 and tsh with the urinary iodine excretion.	the urinary iodine excretion, expressed as the iodine/creatinine (i/cr) ratio, was correlated with the serum t4 and tsh levels in persons with a relatively constant iodine intake for at least 6 months. it was found that the group with an i/cr ratio of 151-200 micrograms/g had on average the lowest serum tsh and the highest serum t4 level. the differences in serum tsh from the other groups were statistically significant, whereas the differences in serum t4 were not. it is concluded that an i/cr r ...	1988	3209822
rapid and simple synthesis for the sulphate esters of 6-hydroxy-melatonin and n-acetyl-serotonin.	melatonin is metabolised by hydroxylation at the 6 position and to a variable extent by demethylation. both metabolites so formed are excreted as sulphate and, to a lesser extent, glucuronide conjugates. to authenticate these metabolites which we had earlier isolated from urine, we wished to have synthetic samples. since we also required them as standards we needed them as powders. a review of the literature showed that there were only two published methods, of which only one gave rise to 6-sulp ...	1988	3210137
genetic analysis of structure and function in phage t4 trnaser.	we have determined the nucleotide sequences of 55 spontaneous mutations that inactivate a suppressor gene of phage t4 trnaser. most of the mutations caused substitutions or deletions of single nucleotides at 18 different positions in the trna. two of three mutations that allowed the synthesis of mature trna had nucleotide substitutions at the junction of the dihydrouridine and anticodon stems, suggesting that this region of trnaser is important for aminoacylation. the third mutation that synthes ...	1988	3210226
full expression of uncoupling protein gene requires the concurrence of norepinephrine and triiodothyronine.	we have examined the uncoupling (ucp) protein gene expression in euthyroid and hypothyroid rats. ucp mrna levels were estimated by northern blot analysis of total rna from brown adipose tissue (bat). stimuli were endogenous (cold) and exogenous norepinephrine (ne), isoproterenol, t3, and t4. while the euthyroid rats ucp mrna levels increase 2- to 3-fold by 2 h after ne or overnight cold exposure, these stimuli and isoproterenol are ineffective in hypothyroid rats. one single dose of t4, equal to ...	1988	3211156
[evaluation of parietal infiltration in carcinoma of the bladder: comparison of mr imaging, ct and histology].	twenty-two patients with bladder carcinoma were examined by mr imaging and ct to determine the degree of parietal involvement. the results were then compared with the surgical and histological findings. a classification in ct and mr stages was elaborated in order to supply corresponding models to clinical tnm staging. three groups were thus formed, corresponding to the evolutive phases of the tumor. the first mr group included t1-t2 forms (accuracy: 75%); the second group included t3a forms (acc ...	1988	3212242
hirsutism due to the treatment with l-thyroxine in patients with thyroid pathology.	there are many factors involved in the aetiology of hirsutism. it is well known that some drugs may cause hirsutism as a side effect, such as phenytoin, diazoxide, minoxidil etc. in turkey, where the endemic goiter constitutes an important health problem, the value of suppression therapy with thyroid hormone still carries a special importance. we established the increasing tendency of hirsutism in patients treated with l-thyroxine (l-t4) for various thyroid pathology. that is why we decided to e ...	1988	3212381
a simplified scheme for the investigation of thyroid function in chronic liver disease.	the investigation of thyroid disease in the presence of chronic liver disease (cld) is difficult. conventional tests are influenced by chronic illness and abnormal concentrations of binding proteins. a three tier system is normally used; thyroxine (t4), then t3 or tsh and an index for binding proteins. the recently introduced tsh immunoradiometric assays (irma) offer the potential of a single test assessment of thyroid function. this was assessed by the measurement of t4, t3, thbc and the free t ...	1988	3214117