Publications

immunoglobulin concentration in treated human acute chagas disease. a follow-up study.	immunoglobulin m, g, and a concentrations were studied by radial immunodiffusion technique in 16 individuals (two were 16 and 14 yr of age, respectively, while the remaining 14 uere 15 yr of age or less) with acute trypanosoma cruzi infection. serum samples were obtained from these patients beginning with the onset of symptoms and continuing until several months after treatment with nifurtimox was completed. soon after infection the concentration of igm was higher than the average found in healt ...	1978	98063
purification of a specific antigen of trypanosoma cruzi from culture forms.	a monospecific rabbit antiserum was prepared against a specific component of tryanosoma cruzi epimastigote culture forms (designated antigen 5). rabbits were immunized intradermally in 30-50 sites with the zone of agarose gel in which the component 5:anti-5 complex was visualized after two-dimensional immunoelectrophoresis. with this appropriate antiserum and the total epimastigote soluble extracts, the specific component of t. cruzi was purified by immunoadsorption. purity and specificity contr ...	1978	98064
synthesis and biological properties of prostaglandin endoperoxides, thromboxanes and prostacyclins.		1978	98074
activity of three 8-hydroxyquinoline derivatives against in vitro dental plaque.	three 8-hydroxyquinoline derivatives, assessed using an in vitro preformed dental plaque model system, were differentially inhibitory for four plaque-forming microorganisms.	1978	98105
thermophilic methanogenesis in a hot-spring algal-bacterial mat (71 to 30 degrees c).	algal-bacterial mats which grow in the effluent channels of alkaline hot springs provided an environment suitable for studying natural thermophilic methane producing bacteria. methane was rapidly produced in cores taken from the meat and appeared to be an end product of decomposition of the algal-bacterial organic matter. formaldehyde prevented production of methane. initial methanogenic rate was lower and methanogenesis became exponential when samples were permitted to cool before laboratory in ...	1978	98110
[alteration of the construction and cellular composition of ileo-colonic lymph nodes of rhesus macaques after administration of salmonella vaccine].	in stained histological sections, percentage ratio of areas to different cellular elements in structural components of the ileocolonic lymph nodes was studied in mature macaca rhesus, normal and after injection of salmonella vaccine. a rather considerable reaction in all structural components and cell composition of the lymph nodes was demonstrated as a response to immunization of the animals. these changes were demonstrated in decreased area occupied by the cortical substance and in increased a ...	1978	98134
analgetic actions of intrathecal opiates in cat and primate.		1978	98219
thyroid-stimulating hormone: neuroregulation and clinical applications. part 2.		1978	98254
biochemical changes in guinea pig lungs due to amosite asbestos.		1978	98326
some effects of progestogens, oestrogens and androgens on the ocular tension of rabbits and owl monkeys.		1978	98336
[attempts at use of indirect hemagglutination in the diagnosis of gonorrhea].		1978	98361
an analysis of group d streptococci recovered from cancer patients.		1978	98452
positive regulation of amidase synthesis in pseudomonas aeruginosa.	mutants of pseudomonas aeruginosa were isolated that were acetamide-negative in growth phenotype at 41 degrees c and constitutive for amidase synthesis at 28 degrees c. two mutants were derived from the magno-constitutive amidase mutant pac111 (c11), and a third from a mutant that had enhanced inducibility by formamide, pac153 (f6). the three temperature-sensitive mutants produced amidases with the same thermal stabilities as the wild-type enzyme. cultures growing exponentially at 28 degrees c, ...	1978	98516
formylation of initiator trna methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression.	eucaryotic and procaryotic organisms differ in two aspects of their translation machinery: polycistronic messengers are expressed as a sequence of individual proteins only in procaryotes, and the initiation of protein synthesis proceeds with an initiator trna which is found to be modified (formylated) in procaryotes and not in eucaryotes. in the present study, we show that formylation is required in vivo for the coordinate expression of the escherichia coli lactose operon. our experiments are co ...	1978	98518
bacteria induce lymphokine synthesis polyclonally in human b lymphocytes.	we have studied the ability of various bacteria to stimulate human lymphocytes to produce leukocyte migration inhibitory factor (lif). mononuclear cells from adult and cord blood as well as purified t and b lymphocytes were stimulated with killed bacteria. the culture supernatants were tested for the presence of lif by the agarose migration method. all nine bacterial strains tested activated unseparated mononuclear cells and b lymphocytes but not t cells to produce lif. lif was also present in c ...	1978	98583
alterations of body fluid compartments and distribution of tissue water and electrolytes in rhesus monkeys with rocky mountain spotted fever.	chair-restrained rhesus monkeys (macaca mulatta) were inoculated subcutaneously with 10(2)--10(3) plaque-forming units of virulent rickettsia rickettsii. the latent period for fever and rickettsemia was three to four days; death occurred six to eight days after infection. total circulatory electrolyte levels and fluid volumes, including plasma, red blood cell, true circulatory blood, and extracellular fluid, increased. the expansion of the extracellular and plasma volumes resembled findings repo ...	1978	98595
antibacterial functions of macrophages in experimental protein-calorie malnutrition. i. description of the model, morphologic observations, and macrophage surface igg receptors.	an experimental protein-calorie malnutrition was produced in weanling sprague-dawley rats. the model resembles human malnutrition with respect to weight loss, inanition, angular stomatitis, anemia, lymphopenia, hypoproteinemia with hypoalbuminemia, and marked thymic involution. in addition, systemic invasion by gram-negative rods was documented. however, no edema was produced, and animals did not survive for longer than six weeks on the protein-deficient diet. one percent glycogen was found to b ...	1978	98598
[value of the use of a cement containing a combination of triamcinolone and tetracycline in cavity preparations].	odontomix (reg'd) cement was used at the bottom of cavities prepared in healthy dog canines in a attempt to prevent pulp and dentine alterations caused by the preparation and filling of cavities. 24 dogs were used along with 24 controls. i.v. tetracycline was afterwards given 10 times at weekly intervals. examination of tetracycline labelling under the cavities showed that the cement caused pulp and dentine changes in confined areas, though it has not yet been possible to determine whether these ...	1978	98698
[retrograde axonal transport of horseradish peroxidase along the striato-thalamic pathways of cats].		1978	98719
the effects of sodium nitroprusside and trimethaphan camsylate on cerebral blood flow in rhesus monkeys.	hemispheric cerebral blood flow was measured in the rhesus monkey before and after infusion of the hypotensive agents sodium nitroprusside and trimethaphan camsylate. the intracarotid injections of 133xe was utilized, and flow was calculated by the "flow initial" technique. cerebral blood flow did not change significantly with the administration of trimethaphan camsylate. however, with a small reduction in blood pressure (10.6%) during the administration of sodium nitroprusside, the cerebral blo ...	1978	98729
changes in composition of tears of malnourished children.		1978	98738
reduced hepatic bilirubin uridine diphosphate glucuronyl transferase and uridine diphosphate glucose dehydrogenase activity in the human fetus.	hepatic bilirubin uridine diphosphate glucuronyl transferase (udpg-t) activity was 0.14 and 0.22 units in two fetuses aged 17 and 22 weeks, respectively, and less than 0.1 unit in 15 fetuses, aged 8--19 weeks compared to 0.68--1.99 units in 21 normal adults. hepatic uridine diphosphate glucose dehydrogenase (udpg-d) activity in 14 fetuses, aged 8--18 weeks, ranged from 6.2--15.0 units (mean = 11.3 +/- 0.7) compared to 28.8--49.2 units (mean = 39.6 +/- 2.5) in eight normal adults (p less than 0.0 ...	1978	98749
microbiology of the vagina in children: normal and potentially pathogenic organisms.	vaginal cultures from 100 healthy girls, 2 months to 15 years of age, were examined for the presence of normal and potentially pathogenic microorganisms. corynebacterium vaginale, yeast species, and genital mycoplasmas were isolated from vaginal cultures from 13.5 %, 28%, and 28% of the girls examined, respectively. colonization with these organisms was not associated with signs or symptoms of vaginitis. neisseria gonorrhoeae was isolated from a 4-year-old with purulent vaginitis. trichomonas va ...	1978	98750
studies on the occurrence of peptococcus indolicus and corynebacterium pyogenes in abscesses in swine, and on the occurrence of pc. indolicus in apparently normal skin and mucous membranes of piglets.	pc. indolicus was isolated from 42.7% and cb. pyogenes from 48.7% of 150 pus-samples from abscesses in pigs (slaughter-house material, table i). in 41 specimens the two organisms were found together. further, pc. indolicus was demonstrated in 22.4% of 290 swabs from apparently normal skin and mucous membranes of piglets (autopsy material, table ii). by gel diffusion analysis the strains of pc. indolicus were referred to the serotypes b, c, d, e, or f. the type distribution (table iii) possibly r ...	1978	98755
[decreased blast transformation reaction and the characteristics of a peripheral blood lymphocyte population in lower monkeys compared to man].		1978	98762
use of t4 rna ligase to construct model substrates for a ribosomal rna maturation endonuclease.	rnase m5 of bacillus subtilis specifically cleaves a 179-nucleotide precursor 5s rrna to yield mature 5s rrna (116 nucleotides) and two fragments derived from the termini. possible recognition elements for rnase m5 within the precursor structure include nucleotide sequences arranged with 2-fold rotational and translational symmetry about the substrate bonds. we have used bacteriophage t4 rna ligase to construct, from synthetic oligonucleotides and mature or precursor 5s rrna fragments, test subs ...	1978	98766
location of the genes for human heavy chain immunoglobulin to chromosome 6.	immunoglobulin synthesis was examined in 31 man-mouse hybrid clones produced by fusing rag mouse cells with human lymphoid cells. cells were grown in serum-free medium containing [(14)c]leucine and a (14)c-labeled amino acid mixture. spent medium was dialyzed, concentrated, and subjected to radioimmunoelectrophoresis. eighteen clones were found to produce material that gave a radiolabeled precipitin line with anti-human igg (gamma-chain specific). production of material which was indistinguishab ...	1978	98768
open-field and lashley iii maze behaviour of the offspring of amphetamine-treated rats.	albino rats of our colony were administered 0.5 mg/kg of d,l-amphetamine sulphate or saline once daily throughout gestation beginning on day 1 of pregnancy. after delivery no other treatment was received by offspring. when adults, the pups of amphetamine-treated mothers had a higher motor activity in the open-field test measured as locomotion and rearing. in the lashley iii maze the treated group made more errors than controls in the first 4 days. after day 4 there seems to be habituation becaus ...	1978	98786
effects of chronic lead exposure on levels of acetylcholine and choline and on acetylcholine turnover rate in rat brain areas in vivo.	rats were exposed to lead acetate from birth, and were killed at the age of 44--51 days for analysis of levels and turnover rates of acetylcholine (ach). steady-state levels of ach were not altered in midbrain, cortex, hippocampus, or striatum of lead-exposed rats. similarly, no changes in choline (ch) concentrations were found in cortex, hippocampus, or striatum. in the midbrain, however, a 30% reduction in ch levels was observed. changes in specific activity of ch and ach were measured as a fu ...	1978	98796
the effects of d-amphetamine and scopolamine on drinking induced by a multiple schedule.	three food-deprived rats obtained food pellets on a multiple fixed-interval fixed-time schedule. during fixed-interval components a 45 mg pellet was made available for a lever-press every minute (fi 1 min). when the fixed-time component was in operation the lever was retracted and a pellet was delivered every minute (ft 1 min) independent of behaviour. a water bottle was available to each subject and similar levels of schedule-induced drinking developed during the two schedule components. the ef ...	1978	98803
mycological and serological studies in the diagnosis of various forms of pulmonary aspergillosis.		1978	98837
vascular dynamics of an experimental cerebral arteriovenous shunt in the primate.	an arteriovenous fistula which shunted arterial blood from the circle of willis to the internal jugular vein was created in ten monkeys. continued patency of the shunt was confirmed angiographically. cerebral blood flow measurements were then obtained with the shunt both open and occluded. flow was also determined in response to elevations of systemic arterial pressure and raised arterial carbon dioxide tensions (paco2), again with the shunt both patent and occluded. in addition, flow through th ...	1978	98854
experimental spinal cord trauma, ii: blood flow, tissue oxygen, evoked potentials in both paretic and plegic monkeys.	graded clinical motor deficits were produced in a series of rhesus monkeys subjected to experimental spinal cord trauma from a variety of impact loads. an argon washout technique was used to measure spinal cord blood flow; tissue oxygen carbon dioxide, and somatosensory evoked potentials (seps) were also monitored. each animal received a clinical grade and, after a week of study, the spinal cords were removed for histopathological grading. blood flow in paraplegic animals was significantly decre ...	1978	98856
rat liver microsomal uptake and irreversible protein binding of [1,2-14c]vinyl bromide.		1978	98862
an ontogenic study of the acute inflammatory response in the fetal rhesus monkey. ii. the mediation of increased vascular permeability by histamine, compound 48/80 and bradykinin.	vascular permeability as a function of age was evaluated quantitatively and morphologically in skin of fetal rhesus monkeys given vasoactive mediators. the response was examined at 90, 120 or 150 days of gestation or at birth and compared to the response of yearling rhesus monkeys. skin sites were challenged with histamine, compound 48/80 or bradykinin. evans' blue and horseradish peroxidase were used as markers of vascular integrity. evans' blue was quantitated spectrophotometrically. vascular ...	1978	98895
[capsule formation in bac. anthracis on a carbon medium].		1978	98898
quantitation of particles in the freeze-fractured nuclear membrane after renal ischemia.	changes in the number and sizes of membrane-associated particles have been quantitated in the protoplasmic (p) and exoplasmic (e) fracture faces of the outer membrane of nuclei isolated from the inner cortex following renal ischemia and reflow in the rat. no changes were observed in the inner nuclear membrane. after 20-min ischemia, the number of particles in both fracture faces decreased. with reflow, the total number of particles decreased after both 20- and 60-min ischemia. the partition coef ...	1978	98907
abnormalities of the nuclear envelope in porcine muscle affected with congenital myofibrillar hypoplasia.	the nuclear ultrastructure of muscle fibres in congenital myofibrillar hypoplasia of piglets was studied in order to provide more information on the pathological changes present. in the initial stages of the disease, muscle fibres with a small reduction of myofibrils often had an increased number of nuclear pores. in the more advanced stages of the disease, the following nuclear abnormalities were observed in muscle fibres showing an extensive disintegration of myofibrils: 1) large dilations of ...	1978	98911
[immunological relations between mother and child during pregnancy (author's transl)].	the relations between the maternal and foetal organisms during pregnancy are partly very complicated and remain inexplicable. blastocyst, trophoblast, embryo and foetus have membrane antigens at a very early stage, and the immunocompetence of the foetus develops already during the second third of the pregnancy period. many non-specific factors are involved in preventing the castingoff reaction of the foetal organism. the trophoblastic tissue is probably of central importance. the focal point of ...	1978	98927
[some aspects relating to the aflatoxin generation during the self-heating of cereals].	in a stored batch of grain which was already affected by mould-formation tests were carried out with the known aflatoxin producer aspergillus flavus. a significantly lower aflatoxin production ensued if the mould growth was not connected with self-heating of the stored product. however, in conformity with increasing mould formation the germinating power was adversely affected and the significant signs (fatty acid number, reductive and none-reductive sugars) were influenced in the grain, irreleve ...	1978	98933
naturally occurring atherosclerotic lesions and ageing changes in the aorta of indian water buffaloes (bubalus-bubalis).		1978	98939
[measurement of the variations of cytoplasmic and nuclear volumes of the absorbing cells of the digestive tube according to the nutritional conditions, in the larva of the common toad (bufo bufo l.)].		1978	98945
improved safety of splenoportography by plugging of the needle tract.	splenoportography, a useful preoperative diagnostic procedure in patients with portal hypertension, has been largely discontinued because of the risk of hemorrhage. we have used both ivalon and gelfoam in particle and plug form to plug the needle tract after splenoportography. initial studies were conducted on six dogs. plugging of the needle tract by injection of suspensions of small gelfoam or ivalon particles resulted in intravasation of these particles into the splenic vein. this was demonst ...	1978	98987
fibrinogen turnover in pregnant rabbits during the first and last thirds of gestation.	although thrombin-mediated fibrinogen derivatives have been observed in normal pregnancy, an increased turnover of fibrinogen has been suspected but has not yet been demonstrated. fibrinogen turnover was studied in 14 pregnant and 10 nonpregnant female rabbits by use of purified rabbit 125i-labeled fibrinogen. in the last third of gestation the half life of fibrinogen was shortened by 45% and the fractional catabolic rate increased by 44% in comparison to the values for the first third of gestat ...	1978	99036
interferon inducing activity of polyinosinic acid.	although poly(i) is generally considered to be inactive as an interferon inducer, we have found several authentic poly(i) preparations to be effective inducers. their interferon inducing ability varied considerably from one cell system to another. in human diploid fibroblasts, primed with interferon and superinduced by cycloheximide and actinomycin d, all active poly(i) samples proved nearly as effective in inducing interferon as poly(i).poly(c). in primary rabbit kidney cell cultures, the activ ...	1978	99486
catabolism and protein binding of tc-99m pyridoxylideneglutamate.	various tc-99m-labeled compounds have been suggested as replacements for [i-131] rose bengal for imaging of the hepatobiliary system. among such compounds are schiff's bases, which are tin-free tc-chelates easily prepared by 30-min autoclaving of an equimolar mixture of pyridoxal and an amino acid at ph 8.5. we have compared the properties of several schiff's bases, including tc-99m pyridoxylideneglutamate (tc pyg) with [i-131] rose bengal. under conditions described, tc-pyg can be prepared free ...	1978	99499
ultrastructural observations on the maturation and secretion of granules in atrial myocardium.		1978	99521
sympathetic joint effusion in septic arthritis.		1978	99527
[salmonella infections].		1978	99539
[transplantation of langerhans' islands].		1978	99549
the effect of polyunsaturated fats on bile acid metabolism and cholelithiasis in squirrel monkeys.	squirrel monkeys (saimiri sciureus) were fed diets containing safflower oil, butter, or coconut oil and 1 mg cholesterol/cal for 15--17 mo to examine the effect of type of fat on cholelithiasis and bile acid metabolism. controls were fed low cholesterol diets containing an isocaloric mixture of the three fats. cholic acid fractional catabolic rate, pool size, chenodeoxycholic acid pool size, and total bile acid pool size and excretion rate were estimated using a modification of lindstedt's isoto ...	1978	99632
evidence for a c-terminal tyrosine residue in human and mouse b-lymphocyte membrane mu chains.		1978	99661
electrophoretic strand separation of long dnas with poly (u,g) in agarose gels.	we have found that binding of poly(u,g) to single-stranded dna decreases its mobility in 0.3% agarose gels. differential binding to the complementary strands of denatured duplex dna provides a simple method for strand separation. the method is shown to work with bacteriophage lambda dna, adenovirus dna and mtdna for tetrahymena pyriformis. in all cases the strand that binds more poly(u,g) in cscl gradients also binds more in gels. the separated strands can be directly blotted from the gel onto n ...	1978	99728
behavioral measurement measurements of excitability changes in reward sites in the dog: a frequency dependent effect.		1978	99757
[method of obtaining crystalline choleragen and choleragenoid preparations].	a new method of concentration and purification developed allows to obtain choleragen and choleragenoid preparations, homogeneous in the immunochemical analysis with regard to the culturing of vibrios producing these substances on the available nonsynthetic nutrient medium. crystalline choleragen and choleragenoid preparations were obtained from highly purified samples. choleragen possessed enterotoxic and skin premeability factors; choleragenoid shows no biological activity.	1978	99923
lumbar spondylectomy in the subhuman primate.	removal of the 2nd or 3rd lumbar vertebrae (or both) has been accomplished in the subhuman primate (macaca mulatta). variations between this animal and the dog in posture, vertebral column anatomy, and spinal cord blood supply made no apparent difference in the results when compared with those in previous experiments. all macaques were able to clinb and to use their hind legs in a normal manner within 3 days after surgical operation. once hair had regrown over the surgical incision, persons not ...	1978	100028
effect of a staphylococcin on neisseria gonorrhoeae.	phage group 2 staphylococcal strain ut0002 contains a large 56s virulence plasmid with genes that code for both exfoliative toxin and a specific staphylococcin termed bac r(1). four penicillinase-producing strains and three penicillin-susceptible strains of neisseria gonorrhoeae were killed by bac r(1). after 30 min of growth of the penicillin-resistant tr1 strain in 62.5 arbitrary units of bac r(1) per ml, loss of viability was approximately 90%, and, after 5 h, an approximately 99.99% loss of ...	1978	100049
[effects of malnutrition on the maturity of the c.n.s. iii. evolution of the largest lipid fractions and gangliosides].		1978	100075
[delayed implantation and early developmental defects in the mouse caused by pcb: 2,2'-dichlorobiphenyl (author's transl)].	pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. based on the investigations during the early development it is concluded, that retardation of the fetus is caused by a delayed implantation. it is assumed, that increased resorption is due t ...	1978	100080
the distribution of hydrolytic enzyme activities in human fibroblast cultures and their intercellular transfer.		1978	100108
increased sensitivity for detection of carcinogen-induced dna repair with the chain terminator dideoxythymidine.		1978	100116
preparation and properties of a phospholipid-free form of microsomal udp-glucuronyltransferase.		1978	100135
[picosecond energy transfer between the spectral forms of pigments from the reaction center of rhodospirillum rubrum].	absorption changes of reaction centers from rhodospirillum rubrum at 748, 796 and 870 nm induced by 532 and 870 nm picosecond light pulses were investigated with a picosecond spectrometer. kinetics of absorption changes at 748 and 796 had an additional bleaching when induced by the 532 nm pulse, in comparison with those at 870 nm. the additional bleaching was interpreted as a result of the excitation energy transfer via spectral forms of pigments of reaction centers. the experimental results fit ...	1978	100143
[origin of a mitogrenic factor for cultivated macrophages (imf: inflammatory mitogenic factor) found in exudates of non-specific acute inflammation].	the mitogenic activity of inflammatory exudate obtained from irradiated rats is reduced. after transfer of bone marrow syngeneic cells into irradiated rats this mitogenic activity is further decreased, while after transfer of thymic cells it is increased. it is postulated that the mitogenic activity of inflammatory exudate could be related to thymic cells and that t lymphocytes may be involved in non specific-inflammatory reactions.	1978	100246
the diet and feeding behaviour of cercopithecus aethiops tantalus.	the feeding behaviour of representative groups of tantalus monkeys (cercopithecus aethiops tantalus) was observed during 1974-1975 in three habitats in cameroon. observations took place during the wet and dry seasons in sahelian savannah, guinea savannah and farmed forest. the tantalus monkeys were similar to other races of c.aethiops that have been studied in that they were omnivorous and lacked any narrow specialisations of either diet or feeding techniques. the dietary range was similar in al ...	1978	101428
purification and characterization of allergens from parietaria officinalis pollen.		1978	101439
antigenicity of purified glutaraldehyde-treated cholera toxoid administered orally.	the antigenicity of orally administered glutaraldehyde-treated cholera toxoid was investigated in healthy volunteers. fourteen volunteers ingested two or three 2-mg doses of toxoid with saline, with the doses spaced at 28-day intervals. thirteen other volunteers received comparable toxoid doses with nahco3 and milk to neutralize gastric acid. increments in circulating antitoxin levels were used to assay the antigenicity of oral toxoid. antitoxin was measured by adrenal cell, rabbit skin permeabi ...	1978	101456
linkage map of pseudomonas aeruginosa pat.	the locations of new markers relative to markers previously mapped on the chromosome of pseudomonas aeruginosa strain pat were defined by generalized transduction with phage f116l and f1083. although the marker orders of the various marker groups were deduced mainly from the results of two-factor crosses, the locations of a number of markers were confirmed by three-factor crosses. a linkage map of the chromosome of p. aeruginosa pat was constructed which shows the relative locations of 50 genes. ...	1978	101525
chromosome-membrane association in bacillus subtilis. iv. further purification of dna-membrane complex by using a combination of centrifugation and electrophoresis.	we have developed a simple procedure to purify a dna-membrane complex from bacillus subtilis by using a combination of centrifugation and electrophoresis. several unique proteins were detected in the purified complex.	1978	101532
tunicamycin-resistant mutants and chromosomal locations of mutational sites in bacillus subtilis.	the types of tunicamycin-resistant mutants of bacillus subtilis were analyzed, and their mutational sites on the chromosome were mapped. a type 1 mutation that simultaneously expressed hyperproductivity of extracellular alpha-amylase was located close to amy e. type 2 mutations were near aroi.	1978	101533
[myelin].	the lipid and protein composition and the metabolic turnover of myelin in the c.n.s., are briefly reported. for a better understanding, it seemed useful to introduce some historical data on the discovery of myelin and to give a morphological description at structural and ultrastructural level.	1978	95501
the value of alpha-fetoprotein and beta-human chorionic gonadotrophin in the management of testicular tumours.	serum alpha-fetoprotein and beta-human chorionic gonadotrophin levels were estimated in 115 patients. sixty-nine patients had non-seminomatous germ cell tumours and 34 patients had seminomas. twenty-six patients showed elevated serum makers.	1978	88986
[the mucosa immune system and immunization by intestinal infections].		1978	88841
4th international workshop on human gene mapping. report of the committee on the genetic constitution of the x and y chromosomes.		1978	88299
[antigenic study of "serratia marcescens" isolated in france.ii.--characterization of o antigens and description of 5 new o factors, occurrence of serotypes and labelling of new h factors (author's transl)].	the somatic o-antigens of 583 french isolates of serratia marcescens were studied with the aid of the tube o-agglutination technique sensitized by centrifugation. flagella antigens were identified by the h-immobilization test. five new o-antigens (o16 to o20) were found. an antigenic factor (co) common to isolates of serotypes o12:h9, o14:h12, o14:h20, and o13:h17 is described. agar cultures of serotypes o12:h9 and o14:h12 dissociated into two colonial types: iridescent colonies, and non-iridesc ...	1978	85425
the thomsen agglutination phenomenon: a discovery revisited 50 years later.		1978	74917
phage-induced changes in vibrio cholerae: serotype and biotype conversions.	phage infection of vibrio cholerae resulted in antigenic changes. a strain of biotype cholerae serotype ogawa was converted into serotype hikojima and gained the ability to synthesize antigenic factor c. some phage-converted strains remained stable after subculture and were immune to superinfection with the same phage. the stable converted strains were lysogenic and released phage having a host range similar to the phage of the donor strain. reinfection of unstable converted strains which had "l ...	1978	75188
antigenic relationship between the common antigen (oep) of pseudomonas aeruginosa and vibrio cholerae.	antibodies were found by the oep-passive hemagglutination test to cross-react with the common antigen (oep) of pseudomonas aeruginosa in sera of rabbits immunized with two serotype (inaba and ogawa) strains of vibrio cholerae. the titer in the oep-passive hemagglutination reaction rose later than did the agglutinin titer and reached a peak of 640 to 1,280. the titers of oep antibody formation in rabbits immunized with v. cholerae were almost the same as that of p. aeruginosa. the common antigen ...	1978	75846
[use of dry nutrient media for identification of the vibrio].		1978	75999
a rapid assay for neuraminidase. the detection of two differences in activity associated with virus transformation.	neuraminidase (acylneuraminyl hydrolase, ec 3.2.1.18) activity in fibroblast homogenates was measured by a rapid and simple assay with a synthetic substrate. the activity of neuraminidase in virus transformed hamster fibroblasts was increased over the normal counterpart. in addition, the differential activity seen using the synthetic substrate and fetuin made it possible to detect an enzyme activity hitherto not described. the advantages of this assay for metabolic screening are discussed.	1978	77684
technical improvements in the mixed antiglobulin rosetting reaction with consequent demonstration of high numbers of immunoglobulin-bearing lymphocytes in viable preparations of human peripheral blood.	a modification of the mixed antiglobulin rosetting reaction (marr) to improve sensitivity as a test for immunoglobulin (ig)-bearing human blood lymphocytes is described. a mean 5.7%, lymphocytes ig-positive by the marr when rosettes were formed in medium containing 0.2% bovine serum albumin (bsa), increased to 20% when rosettes were formed in 5% bsa or by incubating the lymphocytes or indicator erythocytes with vibrio cholerae neuraminidase before rosetting. under these various rosetting conditi ...	1978	78951
lipopolysaccharides of vibrio cholerae (ii)--an immunochemical study on o-antigenic structure-- [proceedings].		1978	79666
interaction between vagal and chemoreceptors afferents in ventilatory response to transient hypercapnia (awake rabbits).	the ventilatory response to a transient hypercapnia was studied in four awake rabbits maintained in a volume displacement plethysmograph : the increase in inspiratory volume (vi) was associated or not with an increase in inspiratory and expiratory durations (ti and te). these ventilatory variations were consistent with the activation of the peripheral chemoreceptors by carbon dioxide (short latency of the initial response). after vagal blockade by local anaesthesia, relative ventilatory variatio ...	1978	80170
stimulation of cyclic amp secretion in vero cells by enterotoxins of escherichia coli and vibrio cholerae.	the morphological response of vero cells to escherichia coli heat-labile enterotoxin was similar to that of cholera toxin and was accompanied by increases in the intracellular level of cyclic amp. the effects of both enterotoxins were enhanced by the presence of phosphodiesterase inhibitor and inhibited by heat or specific antisera. accumulation of cyclic amp preceded the morphological response.	1978	80381
evidence of acquired immune deficiencies in mediterranean lymphoma. a possible aetiological link.	patients with mediterranean lymphoma (m.l.) had a significant reduction in humoral immunity (igg and igm) as well as impaired cellular immunity (50% were anergic to three antigens--p.p.d., mumps, and dinitrochlorobenzene). any hypothesis for the pathogenesis of m.l. has to account for the peculiar geographic distribution of the disease, the age and sex incidence, the plasma-cell nature of the tumours, the associated heavy plasmacytic proliferation with relatively intact intestinal mucosa, involv ...	1978	80636
cholera, non-vibrio cholera, and stomach acid.	fasting and postprandial stomach acid production were low in 16 of 37 bangalees convalescing from cholera or non-vibrio cholera. gastric juice of hypochlorhydric patients did not kill cholera vibrios in vitro, whereas that from normochlorhydric patients rapidly killed vibrios in concentrations up to 10(10)/ml. to determine whether hypoacidity resulted from cholera or was a common predisposing factor, basal and betazole-hydrochloride-stimulated acid production were measured before and after chole ...	1978	81410
cannabis, hypochlorhydria, and cholera.	in 90 volunteers participating in a vaccine-development programme consumption of beer more than 3 days a week was linked with high stomach acid output, and smoking of cannabis greater than 2 days a week was linked with low acid output. in 92 volunteers challenged with vibrio cholerae or enterotoxigenic escherichia coli, heavy use of cannabis was associated with more voluminous diarrhoea. cannabis use may be an important factor predisposing to severe diarrhoea.	1978	81411
pathophysiological effects of vibrio cholerae and enterotoxigenic escherichia coli and their exotoxins on eucaryotic cells.		1978	82199
demonstration of shared and unique immunological determinants in enterotoxins from vibrio cholerae and escherichia coli.	immunodiffusion and biological neutralization studies demonstrated that the heat-labile enterotoxin (lt) from escherichia coli has antigenic determinants in common with each of the isolated subunits (a and b) of the enterotoxin (choleragen) from vibrio cholerae. each of the enterotoxins also possesses unique antigenic specificities. monospecific antiserum to lt was prepared by immunization with antigens derived by immune precipitation of e. coli cell-free supernatant with isolated specific antic ...	1978	83301
antivibrionic activity of some glycolytic cycle enzymes of animal cells.	the antivibrionic activity of crystalline preparations of five enzymes of the glycolytic cycle of animals cells was investigated. phosphorylase "a" (0.5 mg/ml), aldolase (15 mg/ml) and pyruvate kinase (0.1 mg/ml) were found to inhibit the proliferation of vibrio cholerae cells; phosphoglucomutase and glyceraldehyde-3-phosphate dehydrogenase at a concentration of 0.25 mg/ml were found to be vibriocidal. a mixture of these enzymes containing 0.062 mg/ml of phosphorylase "a" and 0.125 mg/ml of each ...	1978	34659
[makeup of a population el tor vibrios according to their agglutinability by type-specific sera].	the authors studied population composition of 14 strains of el tor vibrios. of 7 strains of ogava serological type the population composition was homogeneous in 2, and heterogeneous in 5. all the 7 strains of el tor vibrios of inaba serological type had homogeneous population composition. changes of the existence conditions of el tor vibrios of ogava serological type, containing in their population 5% cells of hikoshima serological tupe, led to separation of the cells of inaba serological type; ...	1978	34303
characteristics of a cholera phage.	the basic physical, chemical and physiological properties of a group ii cholera phage belonging to mukerjee's classification has been described.	1978	32857
modification of the immunologic properties of the cell surface.	living cf1 mouse-transplantable spontaneous mammary adenocarcinoma cells were modified with glutaraldehyde, formalin, 2,4,6-trinitrophenylate, vibrio cholerae neurominidase, iodoacetate, heparin, histamine and adenosine 3'5'-monophosphate (camp), then used to immunize syngeneic cf1 mice. animals immunized with the fixed (formalinized or glutaraldehyde fixed) neuraminidase-treated cells or the membrane of these cells, rejected two challenging doses of 10(8) viable unmodified adenocarcinoma cells. ...	1978	24583
narcotic cueing properties of intraventricularly administered sufentanil, fentanyl, morphine and met-enkephalin.	the narcotic cueing activity of sufentanil, fentanyl, morphine and met-enkephalin was studied upon their injection into the lateral brain ventricle of the rat. comparative studies on the analgesic activity of the three narcotics support a close correlation between the narcotic cueing and the analgesic activity of narcotic drugs.	1978	22444
calf liver nuclear n-acetyltransferases. purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities.	calf liver contains two nuclear n-acetyltransferases which are separated by chromatography on hydroxylapatite. both acetyltransferase a and acetyltransferase b will transfer acetate from acetyl-coa to either histone or spermidine. the same protein catalyzes the reaction with both substrates; this is shown by a constant ratio of spermidine to histone activity over a 5,000-fold purification and identical heat denaturation kinetics for both spermidine and histone acetyltransferase activity with eac ...	1978	22543
a galactose specific agglutinin, a blood-group h active polysaccharide, and a trypsin inhibitor in albumin glands and eggs of arianta arbustorum (helicidae).		1978	24667
capacity for postradiation recovery in bacteria of the genus vibrio when gamma-irradiated cells are incubated in phosphate buffer (ph 8.6) and inoculated on different nutrient media.		1978	24863
direct evidence of two types of beta adrenoceptor binding site in lung tissue.		1978	25391
recurrent genital candidosis in women and the effect of intermittent prophylactic treatment.		1978	26452
neurochemical and operant behavioral studies of a strain of alcohol-preferring rats.	the levels of serotonin (5-ht), 5-hydroxyindoleacetic acid, tyrosine (tyr), norepinephrine (ne), acetylcholine, gaba, glutamate (glu), aspartate (asp), alanine, glycine (gly) and taurine were measured in the cns of adult male rats selectively inbred to the f8 generation for alcohol preference (p) and non-preference (np). with respect to the values found in the np group, higher levels of 5-ht, gaba, glu and gly and lower levels of asp were found in the diencephalon-mesencephalon (d-m) and higher ...	1978	27820