Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| plasmablastic lymphoma in hiv patients: experience at a tertiary care hospital in eastern india. | plasmablastic lymphoma (pbl), a rare non-hodgkin's lymphoma (nhl) variant specifically associated with human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids), expresses well-differentiated plasma cell markers like cd138, bright cd38, and mum1; but not conventional b-cell markers. it occurs at unusual sites like oral cavity and orbit, and has poor survival rates. | 2016 | 26960478 |
| epstein barr virus and mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of ms patients. | mycobacterium avium subsp. paratuberculosis (map) and epstein-barr virus (ebv) epitopes elicit a consistent humoral response in serum of multiple sclerosis patients, but the cross reactivity against the homologous myelin basic protein (mbp) and human interferon regulatory factor 5 (irf5) has not been searched within the cerebral spinal fluid (csf). we evaluated in sera and csf of patients with ms and with other neurological diseases (ond) the humoral response against ebv/map peptides and the irf ... | 2016 | 26956729 |
| methotrexate-associated ebv-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. | rheumatoid vasculitis (rv) is one of the most serious extra-articular complications of rheumatoid arthritis (ra), generally treated with a high dose of immunosuppressive drugs. recently, we encountered two cases of ulcerative vasculitis in methotrexate (mtx)-prescribed ra patients, which simulated rv; however, epstein-barr virus (ebv)-encoded rna in situ hybridization on their skin biopsies revealed many ebv-positive lymphocytes (over 50 cells/high-power field) within the vessel walls and periva ... | 2016 | 26955985 |
| novel insights into the early histopathogenesis of immunodeficiency-associated burkitt lymphoma: a case report of burkitt microlymphoma arising within hiv lymphadenitis. | to report a case detailing the early histopathogenesis of burkitt lymphoma (bl), epstein-barr virus (ebv) positive, in the clinical setting of hiv infection. | 2016 | 26953628 |
| chronic active ebv infection with features of granulomatosis with polyangiitis. | herein, we report the case of a 13-year-old boy with multiple recurrent ulcers on his legs. he developed severe sinusitis at 10 years of age and had significant weight loss (6 kg) in the 2 months prior to admission. histology of tissue biopsied from the ulcer indicated small vessel vasculitis and granulomatous inflammation. given that these findings met the diagnostic criteria for granulomatosis with polyangiitis (gpa), he was treated with immunosuppressive agents. further pathology, however, in ... | 2016 | 26952849 |
| ebv noncoding rna eber2 interacts with host rna-binding proteins to regulate viral gene expression. | epstein-barr virus (ebv) produces a highly abundant noncoding rna called ebv-encoded rna 2 (eber2) that interacts indirectly with the host transcription factor paired box protein 5 (pax5) to regulate viral latent membrane protein 1/2 (lmp1/2) gene expression as well as ebv lytic replication. to identify intermediary proteins, we isolated eber2-pax5-containing complexes and analyzed the protein components by mass spectrometry. the top candidates include three host proteins splicing factor proline ... | 2016 | 26951683 |
| whole-exome sequencing identifies mst1r as a genetic susceptibility gene in nasopharyngeal carcinoma. | multiple factors, including host genetics, environmental factors, and epstein-barr virus (ebv) infection, contribute to nasopharyngeal carcinoma (npc) development. to identify genetic susceptibility genes for npc, a whole-exome sequencing (wes) study was performed in 161 npc cases and 895 controls of southern chinese descent. the gene-based burden test discovered an association between macrophage-stimulating 1 receptor (mst1r) and npc. we identified 13 independent cases carrying the mst1r pathog ... | 2016 | 26951679 |
| severe skin complications after small bowel transplantation: graft-versus-host disease, dress, virus, or drug toxicity? | severe skin problems are uncommon after small bowel transplantation. differential diagnosis includes drug reactions, infections, graft-versus-host disease (gvhd), and mixed diseases. early diagnosis and treatment are determinant for prognosis. | 2016 | 26950725 |
| gastric adenocarcinoma microrna profiles in fixed tissue and in plasma reveal cancer-associated and epstein-barr virus-related expression patterns. | microrna expression in formalin-fixed paraffin-embedded tissue (ffpe) or plasma may add value for cancer management. the gastrogenus mir panel was developed to measure 55 cancer-specific human micrornas, epstein-barr virus (ebv)-encoded micrornas, and controls. this q-rtpcr panel was applied to 100 ffpes enriched for adenocarcinoma or adjacent non-malignant mucosa, and to plasma of 31 patients. in ffpe, micrornas upregulated in malignant versus adjacent benign gastric mucosa were hsa-mir-21, -15 ... | 2016 | 26950485 |
| extreme hypertriglyceridemia in an infant with hemophagocytic lymphohistiocytosis and hydroxycobalamin deficiency. | hemophagocytic lymphohistiocytosis (hlh) is a severe hyperinflammatory condition characterized by fever, cytopenias, hepatosplenomegaly and hemophagocytosis. hlh may be primary or secondary to infection, autoimmune disease or malignancy. hypertriglyceridemia is a common abnormality in hlh and one of the hlh-2004 diagnostic criteria. | 2016 | 26946773 |
| disseminated anetoderma in a patient with nodal epstein-barr virus-associated classical hodgkin lymphoma: anetodermic form of a concurrent discordant cutaneous marginal zone lymphoma. | patients with a lymphoma have an increased risk of developing a second lymphoproliferative disorder. the association of nodal hodgkin lymphoma and primary cutaneous marginal zone lymphoma (malt type) is exceptional, and only very few cases have been documented. anetoderma represents a circumscribed loss or rarefication of elastic fibers. different underlying processes may result in anetoderma, including cutaneous marginal zone lymphoma. we report a 50-year-old male patient with epstein-barr viru ... | 2016 | 26945704 |
| comparison of clinicopathologic parameters and survivals between epstein-barr virus-positive and her2-positive gastric cancers. | gastric carcinomas are highly mortal neoplasms for which new therapeutic options are being searched. the molecular subtyping of gastric adenocarcinomas was proposed recently, and the relationship between etiopathogenetic types is still under investigation. here we compared histopathologic, prognostic, and survival differences between epstein-barr virus (ebv)-positive and her2-positive gastric adenocarcinomas. in a retrospective design, we searched the ebv status with epstein barr virus encoded s ... | 2016 | 26945448 |
| epstein-barr virus hemorrhagic meningoencephalitis: case report and review of the literature. | neurologic complications related to epstein-barr virus (ebv) in immunocompetent adults are rare and most commonly self-limited. however, severe cases have been previously reported in the literature. we describe a case of meningoencephalitis with frontal bilateral hemorrhage in a non-immunocompromised adult following an ebv infection of the central nervous system confirmed by the presence of ebv-dna in the cerebrospinal fluid. during the patient's hospital stay, there was a favorable clinical and ... | 2016 | 26942617 |
| phase i clinical trial of 4-1bb-based adoptive t-cell therapy for epstein-barr virus (ebv)-positive tumors. | although adoptive cell therapy using ag-specific t cells has been tested successfully in the clinic, the production of these t cells has been challenging. by applying our simple and practical 4-1bb-based method for the generation of ag-specific cd8 t cells, here we determined the maximum tolerated dose, toxicity profile, immunologic responses, and clinical efficacy of autologous epstein-barr virus (ebv)/lmp2a-specific cd8 t cells (ebv-induced natural t cell; ebvint) in patients with relapsed/ref ... | 2016 | 26938947 |
| valpromide inhibits lytic cycle reactivation of epstein-barr virus. | reactivation of epstein-barr virus (ebv) from latency into the lytic phase of its life cycle allows the virus to spread among cells and between hosts. valproic acid (vpa) inhibits initiation of the lytic cycle in ebv-infected b lymphoma cells. while vpa blocks viral lytic gene expression, it induces expression of many cellular genes, because it is a histone deacetylase (hdac) inhibitor. here we show, using derivatives of vpa, that blockade of ebv reactivation is separable from hdac inhibition. v ... | 2016 | 26933051 |
| novel targets in the treatment of advanced gastric cancer: a perspective review. | gastric cancer is responsible for a high burden of disease globally. although more extensive use of chemotherapy together with the recent introduction of the two targeted agents trastuzumab and ramucirumab have contributed to marginal outcome prolongation, overall survival for patients with advanced stage disease remains poor. over the last decade, a number of novel agents have been examined in clinical trials with largely disappointing results. potential explanations for this are the absence of ... | 2016 | 26929787 |
| macrophage inflammatory protein 1 alpha (mip-1α) may be associated with poor outcome in patients with extranodal nk/t-cell lymphoma. | the macrophage inflammatory protein 1α (mip-1α) is anticipated to have a role in extranodal natural killer (nk)/t-cell lymphoma (enktl) because the expression of mip-1α is related to epstein-barr virus (ebv) latency in ebv-related non-hodgkin lymphoma cells. thus, we measured the serum level of mip-1α in 69 patients with enktl using frozen serum samples that were archived at diagnosis. as serum level of mip-1α was not detectable in 19 patients (range: 0-24.37 pg/ml), patients were dichotomized i ... | 2016 | 26928433 |
| from conventional to next generation sequencing of epstein-barr virus genomes. | genomic sequences of epstein-barr virus (ebv) have been of interest because the virus is associated with cancers, such as nasopharyngeal carcinoma, and conditions such as infectious mononucleosis. the progress of whole-genome ebv sequencing has been limited by the inefficiency and cost of the first-generation sequencing technology. with the advancement of next-generation sequencing (ngs) and target enrichment strategies, increasing number of ebv genomes has been published. these genomes were seq ... | 2016 | 26927157 |
| artificial antigen-presenting cells expressing hla class ii molecules as an effective tool for amplifying human specific memory cd4(+) t cells. | owing to their multiple immune functions, cd4(+) t cells are of major interest for immunotherapy in chronic viral infections and cancer, as well as for severe autoimmune diseases and transplantation. therefore, standardized methods allowing rapid generation of a large number of cd4(+) t cells for adoptive immunotherapy are still awaited. we constructed stable artificial antigen-presenting cells (aapcs) derived from mouse fibroblasts. they were genetically modified to express human leukocyte anti ... | 2016 | 26924643 |
| prognostic impact of plasma epstein-barr virus dna in patients with nasopharyngeal carcinoma treated using intensity-modulated radiation therapy. | the prognostic value of plasma epstein-barr virus (ebv) dna remains unknown in nasopharyngeal carcinoma (npc) treated with intensity-modulated radiation therapy (imrt). we retrospectively reviewed medical records of 584 newly diagnosed patients with nonmetastatic and biopsy-proven npc treated using imrt. plasma ebv dna concentration was measured before therapy (pre-dna) and within 1 month of completing therapy (post-dna) using real-time quantitative polymerase chain reaction. receiver operating ... | 2016 | 26924234 |
| comparative proteomics analysis of apoptotic spodoptera frugiperda cells during p35 knockout autographa californica multiple nucleopolyhedrovirus infection. | infection with autographa californica multiple nucleopolyhedrovirus (acmnpv) mutants lacking a functional p35 gene can induce host cell apoptosis, which provides the possibility to use the potential of these viruses in the biological control of pest insects. nonetheless, the proteomics or the protein changes of spodoptera frugiperda (sf9) cells infected with p35 knockout acmnpv have not yet been studied. to further improve the use of acmnpv, we set out to analyze the protein composition and prot ... | 2016 | 26922645 |
| caspase-dependent cleavage regulates protein levels of epstein-barr virus-derived latent membrane protein 1. | epstein-barr virus (ebv)-encoded latent membrane protein-1 (lmp1) plays pathogenic roles in ebv-related diseases. thus, host cells employ several mechanisms to regulate lmp1 functions, and we previously reported possible regulation by signal transducing adaptor protein-2 as well as bs69. here, we found that caspase-3 mainly degraded lmp1 proteins in hela cells, leading to decreased nf-κb and stat3 activation. caspase-3 cleaved the consensus dntd sequences in the ctar3 region of lmp1. of importan ... | 2016 | 26921582 |
| high levels of antibody that neutralize b-cell infection of epstein-barr virus and that bind ebv gp350 are associated with a lower risk of nasopharyngeal carcinoma. | elevated iga antibodies indicative of ongoing exposure to epstein-barr virus (ebv) are high-risk biomarkers for nasopharyngeal carcinoma (npc), an ebv-related epithelial tumor. however, protective biomarkers that limit exposure to the virus have not been defined. we evaluated whether antibodies that can neutralize ebv infection by targeting glycoproteins involved in viral cell entry, including ebv vaccine candidate glycoprotein 350 (gp350), were associated with lower npc risk. | 2016 | 26920891 |
| cigarette smoking complements the prognostic value of baseline plasma epstein-barr virus deoxyribonucleic acid in patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy: a large-scale retrospective cohort study. | we evaluated the combined prognostic value of cigarette smoking and baseline plasma epstein-barr virus deoxyribonucleic acid (ebv dna) in patients with nasopharyngeal carcinoma (npc) treated with intensity-modulated radiation therapy (imrt). of consecutive patients, 1501 with complete data were eligible for retrospective analysis. smoking index (si; cigarette packs per day times smoking duration [years]), was used to evaluate the cumulative effect of smoking. primary end-point was overall surviv ... | 2016 | 26919237 |
| the structure-function relationships of complement receptor type 2 (cr2; cd21). | human complement receptor type 2 (cr2; cd21) is a surface-associated glycoprotein which binds to a variety of endogenous ligands, including the complement component c3 fragments ic3b, c3dg and c3d, the low-affinity ige receptor cd23, and the type i cytokine, interferon-alpha. cr2 links the innate complement-mediated immune response to pathogens and foreign antigens with the adaptive immune response by binding to c3d that is covalently attached to targets, and which results in a cell signalling p ... | 2016 | 26916158 |
| in epstein-barr virus-associated gastric carcinoma a high density of cd66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis. | epstein-barr virus-associated gastric carcinoma (ebvagc) is characterized by prominent intratumoral lymphocyte infiltration, with some infiltration by other types of inflammatory cells, such as neutrophils. in this study, the significance of tumor-associated neutrophils (tans) and cytotoxic t lymphocytes (ctls) was investigated in ebvagc. cd66b-positive tans and cd8-positive ctls in surgically resected ebvagc tissues were evaluated by immunohistochemistry and digital imaging analysis. cut-off va ... | 2016 | 26915031 |
| outcomes for paediatric burkitt lymphoma treated with anthracycline-based therapy in malawi. | burkitt lymphoma (bl) is the most common paediatric cancer in sub-saharan africa (ssa). anthracyline-based treatment is standard in resource-rich settings, but has not been described in ssa. children ≤18 years of age with newly diagnosed bl were prospectively enrolled from june 2013 to may 2015 in malawi. staging and supportive care were standardized, as was treatment with chop (cyclophosphamide, doxorubicin, vincristine, prednisone) for six cycles. among 73 children with bl, median age was 9·2 ... | 2016 | 26914979 |
| migration and multiple sclerosis in immigrants from united kingdom and ireland to australia: a reassessment. iii: risk of multiple sclerosis in uki immigrants and australian-born in hobart, tasmania. | our previous work suggested that migrants from the united kingdom and ireland (uki) to australia who left their home country at a young age had a longer interval between immigration and onset and likely acquired ms in australia. in the present study, we reassessed australian-born cases of ms identified in hobart, tasmania, a relatively high-risk zone, in our 1981 survey and compared these with cases of ms in uki immigrants incident in australia. the incidence of ms in australian-born residents r ... | 2016 | 26914927 |
| hydroa vacciniforme-like ebv-positive cutaneous t-cell lymphoma, first report of 2 cases in ecuador. | hydroa vacciniforme-like cutaneous lymphoma is a very rare epstein-barr virus positive peripheral t-cell lymphoma affecting asian and hispanic children and young adults with a defective cytotoxic immune response to ebv predisposing to the development of the disease. we report on 2 ecuadorian patients with papulovesicular and ulcerated crusted lesions on the face, upper and lower extremities and abdomen, with aggressive clinical course and, in one case, a fatal outcome. the histological and molec ... | 2016 | 26913846 |
| [research advances on extranodal nasal type nk/t cell lymphoma--review]. | extranodal nk/t cell lymphoma is a relatively uncommon type of non-hodgkin's lymphoma, which is prevalently distributed in asia and south america, and is highly associated with epstein-barr virus (ebv) infection. due to its highly aggressive course and poor response to treatment because of its multi-drug resistance, for the timebeing there is not yet a definite treatment strategy. the clinical manifestation, pathological diagnosis and the progress of treatment methods of entnkcl are reviewed bel ... | 2016 | 26913435 |
| assessment of epstein-barr virus nucleic acids in gastric but not in breast cancer by next-generation sequencing of pooled mexican samples. | gastric (gc) and breast (brc) cancer are two of the most common and deadly tumours. different lines of evidence suggest a possible causative role of viral infections for both gc and brc. wide genome sequencing (wgs) technologies allow searching for viral agents in tissues of patients with cancer. these technologies have already contributed to establish virus-cancer associations as well as to discovery new tumour viruses. the objective of this study was to document possible associations of viral ... | 2016 | 26910355 |
| expression and prognostic roles of pik3ca, jak2, pd-l1, and pd-l2 in epstein-barr virus-associated gastric carcinoma. | as a special subtype of gastric carcinoma, epstein-barr virus (ebv)-associated gastric carcinoma (ebvagc) has distinct clinicopathological features. the cancer genome atlas research network revealed that ebvagc also has distinct molecular features: pik3ca mutations, dna hypermethylation, and jak2, pd-l1, and pd-l2 amplification. here, we evaluated pik3ca, jak2, pd-l1, and pd-l2 expression in 59 ebvagc and 796 ebv-negative gastric carcinoma (ebvngc) cases using immunohistochemistry and found that ... | 2016 | 26980034 |
| role of viral mirnas and epigenetic modifications in epstein-barr virus-associated gastric carcinogenesis. | micrornas are short (21-23 nucleotides), noncoding rnas that typically silence posttranscriptional gene expression through interaction with target messenger rnas. currently, mirnas have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. additionally, recent studies reported that mirnas can also be encoded by certain single-cell eukaryotes and by viruses. the vast majority of viral mirnas are encoded by the herpesviruses family. these dna viruses incl ... | 2016 | 26977250 |
| spironolactone blocks epstein-barr virus production by inhibiting ebv sm protein function. | clinically available drugs active against epstein-barr virus (ebv) and other human herpesviruses are limited to those targeting viral dna replication. to identify compounds directed against other steps in the viral life cycle, we searched for drugs active against the ebv sm protein, which is essential for infectious virus production. sm has a highly gene-specific mode of action and preferentially enhances expression of several late lytic cycle ebv genes. here we demonstrate that spironolactone, ... | 2016 | 26976570 |
| de novo proliferative glomerulonephritis with monoclonal igg deposits of the igg1κ subtype in a kidney allograft. | proliferative glomerulonephritis with monoclonal immunoglobulin g (igg) deposits (pgnmid) has recently been described in cases with glomerular disease. only 16 cases of recurrent or de novo pgnmid have been reported in the transplanted kidney. here we report a case of de novo pgnmid in a renal allograft diagnosed in the early stage by protocol biopsy. a 41-year-old male with end-stage kidney disease caused by focal glomerular sclerosis received a living-related kidney transplant. the post-transp ... | 2016 | 26976360 |
| lymphoepithelioma-like gastric carcinoma: a case report and review of the literature. | lymphoepithelioma-like gastric carcinoma is a rare type of gastric cancer characterized by a carcinoma with intense stromal lymphocytic infiltration. although lymphocytic infiltration is closely associated with epstein-barr virus (ebv) infection, concomitant occurrence with differentiated adenocarcinoma is relatively rare. the clinical manifestations of lymphoepithelioma-like gastric carcinoma (including ebv-positive and -negative forms) are similar to those of gastric cancer, and the diagnosis ... | 2016 | 26973402 |
| meta-analysis of genome-wide association studies reveals genetic overlap between hodgkin lymphoma and multiple sclerosis. | based on epidemiological commonalities, multiple sclerosis (ms) and hodgkin lymphoma (hl), two clinically distinct conditions, have long been suspected to be aetiologically related. ms and hl occur in roughly the same age groups, both are associated with epstein-barr virus infection and ultraviolet (uv) light exposure, and they cluster mutually in families (though not in individuals). we speculated if in addition to sharing environmental risk factors, ms and hl were also genetically related. usi ... | 2016 | 26971321 |
| comprehensive profiling of ebv gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing. | the latent expression pattern of epstein-barr virus (ebv) genes in nasopharyngeal carcinoma (npc) has been extensively investigated, and the expression of several lytic genes in npc has been reported. however, comprehensive information through ebv transcriptome analysis in npc is limited. we performed paired-end rna-seq to systematically and comprehensively characterize the expression of ebv genes in npc tissue and c666-1 npc cell line, which consistently carries ebv. in addition to the transcri ... | 2016 | 26969667 |
| ebv reactivation as a target of luteolin to repress npc tumorigenesis. | nasopharyngeal carcinoma (npc) is a malignancy derived from the epithelial cells of the nasopharynx. although a combination of radiotherapy with chemotherapy is effective for therapy, relapse and metastasis after remission remain major causes of mortality. epstein-barr virus (ebv) is believed to be one of causes of npc development. we demonstrated previously that ebv reactivation is important for the carcinogenesis of npc. we sought, therefore, to determine whether ebv reactivation can be a targ ... | 2016 | 26967558 |
| lymphomatoid granulomatosis with paraneoplastic polymyositis: a rare malignancy with rare complication. | lymphomatoid granulomatosis is a rare epstein-barr virus driven lymphoproliferative disease. it most commonly presents with symptoms of lung involvement such as cough, chest tightness, and dyspnea or constitutional symptoms of weight loss, malaise, and fever. the diagnosis is obtained by biopsy and histopathology. here we report the case of a 31-year-old male who presented with weight loss, rash, and weakness and was diagnosed with lymphomatoid granulomatosis with paraneoplastic polymyositis. we ... | 2016 | 26966605 |
| viral carcinogenesis beyond malignant transformation: ebv in the progression of human cancers. | cancer progression begins when malignant cells colonize adjacent sites, and it is characterized by increasing tumor heterogeneity, invasion and dissemination of cancer cells. clinically, progression is the most relevant stage in the natural history of cancers. a given virus is usually regarded as oncogenic because of its ability to induce malignant transformation of cells. nonetheless, oncogenic viruses may also be important for the progression of infection-associated cancers. recently this hypo ... | 2016 | 27068530 |
| [molecular subtypes of gastric cancer]. | gastric cancer has been classified based on the pathological characteristics including microscopic configuration and growth pattern. although these classifications have been used in studies investigating prognosis and recurrence pattern, they are not considered for decisions regarding the therapeutic strategy. in the toga study, trastuzumab, an anti-her2 monoclonal antibody, demonstrated clinical efficacy for gastric cancer with her2 overexpression or her2 gene amplification. based on these find ... | 2016 | 27067842 |
| epstein-barr virus-associated lymphoepithelial carcinoma after pediatric liver transplant. | 2016 | 27065464 | |
| cordycepin enhances epstein-barr virus lytic infection and epstein-barr virus-positive tumor treatment efficacy by doxorubicin. | the consistent latent presence of epstein-barr virus (ebv) in tumor cells offers potential for virus-targeted therapies. the switch from the latent form of ebv to the lytic form in tumor cells can lead to tumor cell lysis. in this study, we report that a natural small molecule compound, cordycepin, can induce lytic ebv infection in tumor cells. subsequently, we demonstrate that cordycepin can enhance ebv reactivating capacity and ebv-positive tumor cell killing ability of low dose doxorubicin. t ... | 2016 | 27063964 |
| rta-igg as a biomarker for diagnosis and post treatment prognostic of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a common type of head and neck cancer. | 2016 | 27062704 |
| immunotherapeutic approaches for the treatment of childhood, adolescent and young adult non-hodgkin lymphoma. | with the introduction of the anti-cd20 monoclonal antibody rituximab, b-cell non-hodgkin lymphoma was the first malignancy successfully treated with an immunotherapeutic agent. since then, numerous advances have expanded the repertoire of immunotherapeutic agents available for the treatment of a variety of malignancies, including many lymphoma subtypes. these include the introduction of monoclonal antibodies targeting a variety of cell surface proteins, including the successful targeting of immu ... | 2016 | 27062282 |
| clonal deleted latent membrane protein 1 variants of epstein-barr virus are predominant in european extranodal nk/t lymphomas and disappear during successful treatment. | extranodal natural killer/t-cell lymphomas (nk/tl), rare in europe, are epstein-barr virus (ebv) associated lymphomas with poor outcomes. here, we determined the virus type and analyzed the ebv latent membrane protein-1 (lmp1) gene sequence in nk/tl from french patients. six clones of viral lmp1 were sequenced by sanger technology in blood from 13 patients before treatment with an l-asparaginase based regimen and, for 8 of them, throughout the treatment. blood lmp1 sequences from 21 patients wit ... | 2016 | 27061907 |
| detection of epstein-barr virus dnaemia after lung transplantation and its potential relationship with the development of post-transplant complications. | recent studies suggest that epstein-barr virus dnaemia (ebvd) may act as a surrogate marker of post-transplant immunosuppression. this hypothesis has not been tested so far in lung transplant (lt) recipients. | 2016 | 27061510 |
| the bdlf3 gene product of epstein-barr virus, gp150, mediates non-productive binding to heparan sulfate on epithelial cells and only the binding domain of cd21 is required for infection. | the cell surface molecules used by epstein-barr virus (ebv) to attach to epithelial cells are not well-defined, although when cd21, the b cell receptor for ebv is expressed epithelial cell infection increases disproportionately to the increase in virus bound. many herpesviruses use low affinity charge interactions with molecules such as heparan sulfate to attach to cells. we report here that the ebv glycoprotein gp150 binds to heparan sulfate proteoglycans, but that attachment via this glycoprot ... | 2016 | 27061054 |
| itk gene mutation: effect on survival of children with severe hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is characterized by deadly hyperinflammatory syndrome, but data on severe hlh with multi-organ dysfunction in children are scant. the authors report a retrospective study of 8 cases with severe hlh from a pediatric intensive care unit (picu) over a 1-y period and found that epstein barr virus (ebv) -infection was the most common etiology. all patients had genetic analysis, which showed that four patients with ebv -infection had one homozygous mutation, c. ... | 2016 | 27056244 |
| epstein-barr virus and gastric cancer risk: a meta-analysis with meta-regression of case-control studies. | research on how the risk of gastric cancer increases with epstein-barr virus (ebv) infection is lacking. in a systematic review that investigated studies published until september 2014, the authors did not calculate the summary odds ratio (sor) due to heterogeneity across studies. therefore, we include here additional studies published until october 2015 and conduct a meta-analysis with meta-regression that controls for the heterogeneity among studies. | 2016 | 27055546 |
| ebv-related malignancies, outcomes and novel prevention strategies. | epstein barr virus (ebv) is a common gamma herpes virus with a high prevalence in adults worldwide. infection is mostly latent in affected individuals. ebv has been linked mostly with lymphoid malignancies but its association with epithelial and other non-lymphoid malignancies has also been described. | 2016 | 27052336 |
| the epstein-barr virus glycoprotein gp150 forms an immune-evasive glycan shield at the surface of infected cells. | cell-mediated immunity plays a key role in host control of viral infection. this is exemplified by life-threatening reactivations of e.g. herpesviruses in individuals with impaired t-cell and/or inkt cell responses. to allow lifelong persistence and virus production in the face of primed immunity, herpesviruses exploit immune evasion strategies. these include a reduction in viral antigen expression during latency and a number of escape mechanisms that target antigen presentation pathways. given ... | 2016 | 27077376 |
| circulating ebv dna, globulin and nodal size predict distant metastasis after intensity-modulated radiotherapy in stage ii nasopharyngeal carcinoma. | the optimal treatment for early-stage nasopharyngeal carcinoma (npc) remains controversial. identification of prognostic factors for metastasis and tumor progression is urgently required to improve clinical decision-making for patients with american joint committee on cancer (ajcc) 2009 stage ii npc from the endemic area. | 2016 | 27076847 |
| multicenter evaluation of whole-blood epstein-barr viral load standardization using the who international standard. | the first who international standard for epstein-barr virus (ebv) (who ebv standard) for nucleic acid amplification technology (nat)-based assays was commercialized in january 2012 by the national institute for biological standards and control. in the study reported here, we compared whole-blood ebv dna load (edl) results from 12 french laboratories for seven samples (quality controls for molecular diagnostics 2013 proficiency panel) in order to determine whether expression in international unit ... | 2016 | 27076661 |
| lymphoepithelioma-like gastric carcinoma in a patient with rectal laterally spreading tumor: a case report. | lymphoepithelioma-like gastric carcinoma (lelgc) is a rare neoplasm of the stomach that accounts for 1-4% of all gastric cancer cases. it is characterized by the presence of a lymphoid stroma with cells arranged primarily in micro alveolar, thin trabecular and primitive tubular patterns or isolated cells. in the present study, the case of a 50-year-old male patient with lelgc and rectal laterally spreading tumor is presented. following endoscopic submucosal dissection, a diagnosis of carcinoma w ... | 2016 | 27073504 |
| glypican-4 gene polymorphism (rs1048369) and susceptibility to epstein-barr virus-associated and -negative gastric carcinoma. | gastric cancer (gc) is one of the most common malignant tumors in china and single nucleotide polymorphisms (snps) have been found to be highly related to gc carcinogenesis. glypican-4 (gpc4), a member of the heparan sulphate proteoglycan family, plays an important role in the regulation of cell growth and differentiation. however, little is known about polymorphisms of gpc4 gene and their associated susceptibility to gc, especially to epstein-barr virus-associated gc (ebvagc). here we studied t ... | 2016 | 27071854 |
| characterization of the variability of epstein-barr virus genes in nasopharyngeal biopsies: potential predictors for carcinoma progression. | epstein-barr virus (ebv) infection is a significant factor in the pathogenesis of nasopharyngeal carcinoma, especially in the undifferentiated carcinoma of nasopharyngeal type (ucnt, world health organization type iii), which is the dominant histopathological type in high-risk areas. the major ebv oncogene is latent membrane protein 1 (lmp1). lmp1 gene shows variability with different tumorigenic and immunogenic potentials. ebv nuclear antigen 1 (ebna1) regulates progression of ebv-related tumor ... | 2016 | 27071030 |
| acute idiopathic scrotal edema caused by epstein-barr virus. | 2016 | 27071015 | |
| epstein-barr virus glycoprotein gh/gl antibodies complement iga-viral capsid antigen for diagnosis of nasopharyngeal carcinoma. | to determine whether measuring antibodies against epstein-barr virus (ebv) glycoprotein gh/gl in serum could improve diagnostic accuracy in nasopharyngeal carcinoma (npc) cases, gh/gl expressed in a recombinant baculovirus system was used in an enzyme-linked immunosorbent assay (elisa) to detect antibodies in two independent cohorts. binary logistic regression analyses were performed using results from a training cohort (n = 406) to establish diagnostic mathematical models, which were validated ... | 2016 | 27093005 |
| role of ebna-3 family proteins in ebv associated b-cell lymphomagenesis. | epstein-barr virus (ebv) is highly ubiquitous in human population and establishes a lifelong asymptomatic infection within the infected host unless the immune system is compromised. following initial infection in the oropharyngeal epithelial cells, ebv primarily infects naive b-lymphocytes and develops a number of b-cell lymphomas particularly in immune-deficient individuals. in vitro, ebv can also infect and subsequently transform quiescent b-lymphocytes into continuously proliferating lymphobl ... | 2016 | 27092119 |
| impact of donor epstein-barr virus serostatus on the incidence of graft-versus-host disease in patients with acute leukemia after hematopoietic stem-cell transplantation: a study from the acute leukemia and infectious diseases working parties of the european society for blood and marrow transplantation. | we investigated the effect of epstein-barr virus (ebv) serostatus on the overall outcome of allogeneic hematopoietic stem-cell transplantation (allo-hsct). | 2016 | 27091716 |
| epstein-barr virus and b cells in the pathogenesis of graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation. | 2016 | 27091710 | |
| epstein-barr virus latency type and spontaneous reactivation predict lytic induction levels. | the human epstein-barr virus (ebv) evades the immune system by entering a transcriptionally latent phase in b cells. ebv in tumor cells expresses distinct patterns of genes referred to as latency types. viruses in tumor cells also display varying levels of lytic transcription resulting from spontaneous reactivation out of latency. we measured this dynamic range of lytic transcription with rna deep sequencing and observed no correlation with ebv latency types among genetically different viruses, ... | 2016 | 27091426 |
| l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia. | aggressive nature killer cell leukemia (ankl) is a mature nk-t cell lymphoma with worse prognosis, but optimal treatment is unclear. therefore, we analyzed the efficacy of l-asparaginase-based regimens for ankl patients. twenty-one patients who received dexamethasone, methotrexate, ifosfamide, l-asparaginase, and etoposide (smile) or etoposide, ifosfamide, dexamethasone, and l-asparaginase (vidl) chemotherapy at samsung medical center were selected. the overall response rate for all patients was ... | 2016 | 27091029 |
| acute acalculous cholecystitis in a lebanese girl with primary epstein-barr viral infection. | acute acalculous cholecystitis (aac) constitutes 5-10% of all cases of cholecystitis in adults, and is even less common in children. the recent literature has described an association between primary epstein-barr virus (ebv) infection and aac, however, it still remains an uncommon presentation of the infection. most authors advise that the management of aac in patients with primary ebv infection should be supportive, since the use of antibiotics does not seem to alter the severity or prognosis o ... | 2016 | 27090538 |
| a nation-wide epidemiological study on the risk of developing second malignancies in patients with different histological subtypes of nasopharyngeal carcinoma. | risk assessment of second head/neck and epstein barr virus (ebv)-related malignancies in patients with different nasopharyngeal carcinoma (npc) subtypes. | 2016 | 27086485 |
| identification of gla/se as an effective adjuvant for the induction of robust humoral and cell-mediated immune responses to ebv-gp350 in mice and rabbits. | childhood infection with epstein-barr virus (ebv) is often asymptomatic and may result in mild flu-like symptoms, but exposure during adolescence and young adulthood can lead to acute infectious mononucleosis (aim) with a pathology characterized by swollen lymph nodes, sore throat, and severe fatigue lasting weeks or months. a vaccine targeting the envelope glycoprotein gp350 adjuvanted with aluminum hydroxide complexed with the tlr4 agonist monophosphoryl lipid a (mpla) achieved a 78% reduction ... | 2016 | 27085175 |
| specific expression and methylation of slit1, slit2, slit3, and mir-218 in gastric cancer subtypes. | slit has been suggested as a key regulator of cancer development and a promising therapeutic target for cancer treatment. herein, we analyzed expression and methylation of slit1/slit2/slit3 in 11 gastric cancer cell lines, 96 paired gastric tumors and adjacent normal gastric tissues, and 250 gastric cancers provided by the cancer genome atlas. methylation of slit1/slit2/slit3 was found both in early gastric cancers, and in advanced gastric cancers. even normal gastric tissue showed increased met ... | 2016 | 27082735 |
| co-prevalence of epstein-barr virus and high-risk human papillomaviruses in syrian women with breast cancer. | abstrat we recently performed 2 studies viewing the presence of epstein-barr virus (ebv) and high-risk human papillomaviruses (hpvs) types 16, 18, 31, 33 and 35 in human breast cancer in the syrian population. herein, we report that ebv and high-risk hpvs are co-present in breast cancer in syrian women. therefore, and based on our previous studies and present data, we reveal that 35 (32%) of 108 cancer samples are positive for both ebv and high-risk hpvs and their co-presence is associated with ... | 2016 | 27082145 |
| expression of epstein-barr virus antibodies ea-igg, rta-igg, and vca-iga in nasopharyngeal carcinoma and their use in a combined diagnostic assay. | epstein-barr virus (ebv) infection is closely associated with nasopharyngeal carcinoma, which can be monitored by the levels of rta protein antibody igg (rta-igg), early antigen antibody (ea-igg), and viral capsid antibody (vca-iga). in the present study, we investigated the serum levels of rta-igg, ea-igg, and vca-iga in nasopharyngeal cancer patients, and the diagnostic value of a combined assay that includes these antibodies in addition to the ebv-dna. a total of 56 nasopharyngeal cancer pati ... | 2016 | 27050964 |
| downregulation of atoh8 induced by ebv-encoded lmp1 contributes to the malignant phenotype of nasopharyngeal carcinoma. | mechanism for the malignant phenotype of nasopharyngeal carcinoma (npc) remains poorly understood. epstein-barr virus (ebv) consistently appears in nearly all malignant npc patient samples, suggesting the strong etiological link between the malignant phenotype and ebv infection. here we found that the ebv-encoded latent membrane protein (lmp1) enhanced cell growth, motility, invasion and xenograft tumor growth of npc. rna-seq profiling analysis of lmp1-positive npc patient tissues indicated that ... | 2016 | 27049918 |
| mechanism of action of ebv, bcl-2, p53, c-myc and rb in non-hodgkin's lymphoma. | the aim of the present study is to explore the mechanism of action of several proteins, including epstein-barr virus (ebv), b-cell lymphoma (bcl)-2, p53, c-myc and retinoblastoma (rb), in non-hodgkin's lymphoma (nhl). | 2016 | 27049262 |
| a novel antibody discovery platform identifies anti-influenza a broadly neutralizing antibodies from human memory b cells. | monoclonal antibody isolation directly from circulating human b cells is a powerful tool to delineate humoral responses to pathological conditions and discover antibody therapeutics. we have developed a platform aimed at improving the efficiencies of b cell selection and v gene recovery. here, memory b cells are activated and amplified using epstein-barr virus infection, co-cultured with cho-mucd40l cells, and then assessed by functional screenings. an in vitro transcription and translation (ivt ... | 2016 | 27049174 |
| computational analysis of ebna1 "druggability" suggests novel insights for epstein-barr virus inhibitor design. | the epstein-barr nuclear antigen 1 (ebna1) is a critical protein encoded by the epstein-barr virus (ebv). during latent infection, ebna1 is essential for dna replication and transcription initiation of viral and cellular genes and is necessary to immortalize primary b-lymphocytes. nonetheless, the concept of ebna1 as drug target is novel. two ebna1 crystal structures are publicly available and the first small-molecule ebna1 inhibitors were recently discovered. however, no systematic studies have ... | 2016 | 27048620 |
| epstein-barr virus and its association with oral hairy leukoplakia: a short review. | in immunocompromised subjects, epstein-barr virus (ebv) infection of terminally differentiated oral keratinocytes may result in subclinical productive infection of the virus in the stratum spinosum and in the stratum granulosum with shedding of infectious virions into the oral fluid in the desquamating cells. in a minority of cases this productive infection with dysregulation of the cell cycle of terminally differentiated epithelial cells may manifest as oral hairy leukoplakia. this is a white, ... | 2016 | 27047546 |
| factors associated with onset, relapses or progression in multiple sclerosis: a systematic review. | multiple sclerosis (ms) is a chronic disease of the central nervous system with an unidentified etiology. we systematically reviewed the literature on the possible risk factors associated with ms disease onset, relapses and progression from 1960 to 2012 by accessing six databases and including relevant systematic reviews, meta-analyses, case-control or cohort studies. the focus was on identifying modifiable risk factors. fifteen systematic reviews and 169 original articles were quality assessed ... | 2016 | 27045883 |
| severe hypersplenism associated to hemophagocytic and lymphoproliferative syndrome secondary to epstein-barr virus infection. a report of two cases. | 2016 | 27041246 | |
| epstein-barr virus reactivation is induced, but abortive, in cutaneous lesions of systemic hydroa vacciniforme and hypersensitivity to mosquito bites. | epstein-barr virus (ebv)-associated t/natural killer (nk)-lymphoproliferative disorders (lpds) include hydroa vacciniforme (hv) and hypersensitivity to mosquito bites (hmb). the pathomechanisms of these diseases are still unclear. | 2016 | 27039668 |
| acute cholestatic hepatitis induced by epstein-barr virus infection in an adult: a case report. | acute cholestatic hepatitis without features of infectious mononucleosis is a rare presentation of primary epstein-barr infection, with only several cases previously reported in the medical literature. early investigation for epstein-barr virus in febrile patients with deranged liver function tests and no demonstrable biliary obstruction on imaging can expedite both diagnosis and treatment, thereby avoiding costly or invasive procedures such as liver biopsy. | 2016 | 27037083 |
| immunological methods for the detection of porcine lymphotropic herpesviruses (plhv). | porcine lymphotropic herpesviruses (plhv-1, -2, and -3) are widespread in pigs and closely related to the human pathogenic gammaherpesviruses epstein-barr virus (human herpesvirus 4, hhv-4) and kaposi sarcoma herpesvirus (hhv-8). in minipigs, plhv-1 causes a porcine post-transplantation lymphoproliferative disorder (ptld) after experimental transplantations. porcine ptld comes with clinical symptoms similar to those of human ptld, a serious complication of solid organ and allogeneic bone marrow ... | 2016 | 27036503 |
| environmental factors and their interactions with risk genotypes in ms susceptibility. | the area of multiple sclerosis (ms) epidemiology has expanded during the last few years. established lifestyle and environmental factors influencing ms risk are epstein-barr virus infection, sun exposure/vitamin d, and smoking. we review these factors and a series of other potential candidates implicated in the pathogenesis of ms and how environmental factors interact with genetic susceptibility with regard to disease risk. | 2016 | 27035899 |
| plasmablastic lymphoma mimicking acute pancreatitis. | background. plasmablastic lymphoma (pbl) is a rare b-cell neoplasm. it predominantly occurs in the oral cavity of human immunodeficiency virus (hiv)-positive patients and exhibits a highly aggressive clinical behavior. case presentation. we describe an unusual case of a 37-year-old hiv-positive male who presented with acute pancreatitis secondary to multiple peripancreatic masses compressing the pancreas. histopathological examination of the lesions showed diffuse and cohesive pattern of large b ... | 2016 | 27034868 |
| murine models of epstein-barr virus-associated lymphomagenesis. | the epstein-barr virus (ebv) is a b-lymphotropic gamma herpes virus associated with a number of malignancies. most ebv-related cancers present complex medical management challenges; thus it has been essential to develop preclinical in vivo models allowing for the study of pathogenesis, prevention, and treatment of these diseases. early in vivo models used nonhuman primates; however, such models were limited by the inability of ebv to achieve viral latency, availability, and cost. immunodeficient ... | 2016 | 27034395 |
| detection of active epstein-barr virus infection in duodenal mucosa of patients with refractory celiac disease. | refractory celiac disease is characterized by mucosal damage in patients with celiac disease despite a gluten-free diet. little is known about the mechanisms that cause persistent intestinal inflammation in these patients. we performed a case-control study of 17 consecutive patients diagnosed with refractory celiac disease from 2001 through 2014 (median age, 51 y; 10 women) and 24 patients with uncomplicated celiac disease (controls) to determine whether refractory disease is associated with inf ... | 2016 | 27033429 |
| a protein and mrna expression-based classification of gastric cancer. | the overall survival of gastric carcinoma patients remains poor despite improved control over known risk factors and surveillance. this highlights the need for new classifications, driven towards identification of potential therapeutic targets. using sophisticated molecular technologies and analysis, three groups recently provided genetic and epigenetic molecular classifications of gastric cancer (the cancer genome atlas, 'singapore-duke' study, and asian cancer research group). suggested by the ... | 2016 | 27032689 |
| killer-specific secretory (ksp37) gene expression in subjects with down's syndrome. | down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. chronic infection by epstein-barr virus is frequently present in subjects with down syndrome. ksp37 gene is commonly expressed by nk, cd8(+) t, γδ t and cd4(+) t cells; these data suggest that ksp37 have cytotoxic properties. an increase of ksp37 protein serum levels it has been showed during the acute phase of epstein-barr virus. in this study, we evaluated the expression of ksp37 mrna, ... | 2016 | 27032399 |
| epstein-barr virus-associated b-cell lymphoproliferative disorder in a patient with sézary syndrome treated by methotrexate. | 2016 | 27031298 | |
| methylation and expression of epstein-barr virus latent membrane protein 1, 2a and 2b in ebv-associated gastric carcinomas and cell lines. | promoter cpg methylation of epstein-barr virus (ebv) genome plays an essential role in maintaining viral latency. latent membrane protein (lmp) 1, 2a and 2b of ebv exert multiple oncogenic properties by activating multiple signal pathways and modulating the expression of various oncogenes. | 2016 | 27026080 |
| periodic illness associated with epstein-barr virus: a new diagnosis after a 22-year follow-up. | 2016 | 27025823 | |
| circulating interleukin-10 levels and human papilloma virus and epstein-barr virus-associated cancers: evidence from a mendelian randomization meta-analysis based on 11,170 subjects. | recent studies have showed interleukin 10 (il-10) is a critical cytokine that determines antiviral immune response and is related to virus-associated cancers. however, whether genetically elevated circulating il-10 levels are associated with the risk of human papilloma virus and epstein-barr virus-associated cancers (heacs) is still unclear. mendelian randomization method was implemented to meta-analyze available observational studies by employing il-10 three variants (-592c>a, -819c>t, and -108 ... | 2016 | 27022283 |
| primary epstein-barr virus infection, seroconversion, and post-transplant lymphoproliferative disorder in seronegative renal allograft recipients: a prospective cohort study. | epstein-barr virus (ebv)-seronegative renal transplant recipients are at risk of post-transplant lymphoproliferative disorder (ptld). we compared primary ebv infection, seroconversion, and ptld in ebv-seronegative patients who received renal allograft from seropositive or seronegative donors (d+/r- and d-/r-, respectively). | 2016 | 27016725 |
| a case report of nk-cell lymphoproliferative disease with a wide involvement of digestive tract develop into epstein-barr virus associated nk/t cell lymphoma in an immunocompetent patient. | epstein-barr virus (ebv) plays an important role in various diseases. ebv-associated lymphoproliferative disease (lpd) is a rare disease with a canceration tendency. it is difficult to differentiate lpd with involvement of digestive tract from crohn disease due to similar clinical and endoscopic manifestations. we present a case report of multiple ulcers with esophagus, small bowel and the entire colon involved, proved to be nk-cell lpd, developed into ebv-associated nk/t cell lymphoma, in an im ... | 2016 | 27015206 |
| origin of cystic squamous cell carcinoma metastases in head and neck lymph nodes: addition of ebv testing improves diagnostic accuracy. | most cases of cystic squamous cell carcinoma (scc) metastases in the upper neck are associated with an oropharyngeal primary, namely human papillomavirus (hpv)-associated scc arising in the palatine or lingual tonsil. a retrospective study was performed on 22 patients who presented with cystic head and neck scc metastases. the purpose of the study was to find out whether histological characteristics, p16 protein expression, hpv and epstein-barr virus (ebv) status could be useful in predicting th ... | 2016 | 27013059 |
| erk2 phosphorylation of ebna1 serine 383 residue is important for ebna1-dependent transactivation. | functional inhibition of epstein-barr virus (ebv)-encoded nuclear antigen 1 (ebna1) can cause the death of ebv infected cells. in this study, a bioinformatics tool predicted the existence of putative extracellular signal-regulated kinase (erk) docking and substrate consensus sites on ebna1, suggesting that erk2 could bind to and phosphorylate ebna1. in accordance, erk2 was found to phosphorylate ebna1 serine 383 in a reaction suppressed by h20 (a structural congener of the erk inhibitor), u0126 ... | 2016 | 27009860 |
| pd-l1 is an independent prognostic predictor in gastric cancer of western patients. | targeting the pd-1/pd-l1 immune checkpoint signaling is a novel promising treatment strategy in several tumor entities, and it is suggested that pd-l1/pd-1 expression is predictive for a pd-1/pd-l1 checkpoint inhibitor treatment response. we investigated the expression of pd-l1 and pd-1 by immunohistochemistry in a large and well characterized gastric cancer (gc) cohort of caucasian patients, consisting of 465 gc samples and 15 corresponding liver metastases. staining results were correlated wit ... | 2016 | 27009855 |
| broadening specificity and enhancing cytotoxicity of adoptive t cells for nasopharyngeal carcinoma immunotherapy. | although promising, clinical responses to adoptive immunotherapy for nasopharyngeal carcinoma (npc) are still limited by the restricted number of epstein-barr virus (ebv) antigens that can be targeted and their poor immunogenicity. our previous work indicated that the immunogenic features of the npc-associated viral antigen barf1 may be exploited for immunotherapeutic purposes. nevertheless, t-cell lines obtained with current protocols include only negligible numbers of barf1-specific cytotoxic ... | 2016 | 27009165 |
| survival analysis of patients with advanced-stage nasopharyngeal carcinoma according to the epstein-barr virus status. | the main aim of this study is to analyze the prognostic differences in nasopharyngeal carcinoma (npc) patients who are positive and negative for epstein-barr virus (ebv). | 2016 | 27008701 |
| [research progress of epstein-barr virus-associated gastric carcinoma]. | epstein-barr virus-associated gastric carcinoma(ebvagc) comprises nearly 10% of gastric carcinoma in the world. ebvagc is supposed to have distinct clinicopathological features, including male predominance, the 'lace pattern' in the early stage, lower rate of lymph node involvement and infiltration of a large number of various inflammatory cells. eber-ish detection is the golden standard in the diagnosis of ebvagc. although there is no special therapy due to the limited understanding, ebvagc has ... | 2016 | 27003661 |
| high-throughput microdissection for next-generation sequencing. | precision medicine promises to enhance patient treatment through the use of emerging molecular technologies, including genomics, transcriptomics, and proteomics. however, current tools in surgical pathology lack the capability to efficiently isolate specific cell populations in complex tissues/tumors, which can confound molecular results. expression microdissection (xmd) is an immuno-based cell/subcellular isolation tool that procures targets of interest from a cytological or histological specim ... | 2016 | 26999048 |