Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| seroprevalence and factors associated with herpes simplex virus type 2 among hiv-negative high-risk men who have sex with men from rio de janeiro, brazil: a cross-sectional study. | herpes simplex virus type 2 (hsv-2) is the leading cause of genital ulcer disease in developing countries, including brazil, and is especially prevalent among men who have sex with men (msm). hsv-2 infection represents a risk factor for the acquisition and transmission of other sexually transmitted diseases. the goal of the present cross-sectional study was to estimate hsv-2 seroprevalence and to determine the factors associated with hsv-2 seropositivity in hiv-negative high-risk msm from rio de ... | 2009 | 19335922 |
| herpes simplex. | after completing this article, readers should be able to: 1. characterize the epidemiology of herpes simplex virus (hsv) infection, including mode of transmission, incubation period, and period of communicability. 2. recognize the difference in clinical manifestations of hsv1 and hsv2 infection. 3. diagnose various manifestations of hsv infection. 4. describe the difference in the clinical manifestations and outcome of hsv infection in newborns and older infants and children. 5. discuss the mana ... | 2009 | 19339385 |
| unusually high hiv infectiousness in an hiv-, hcv- and hsv-2-coinfected heterosexual man. | we report an hiv-hcv-hsv-2-coinfected man, who infected all of five sequential female sexual partners within seven years. hiv-rna in semen was unusually high and exceeded that in plasma by one log10. screening for sexually transmitted diseases remained negative with the exception of hsv-2-seropositivity. recurrent asymptomatic genital herpes might explain the patient's increased hiv-rna shedding in semen. | 2009 | 19350427 |
| simultaneous identification of 14 genital microorganisms in urine by use of a multiplex pcr-based reverse line blot assay. | the aim of this study was to develop and evaluate a sensitive method for the simultaneous identification of 14 urogenital potential pathogens. a multiplex pcr-based reverse line blot (mpcr/rlb) assay was developed to detect 14 urogenital pathogens or putative pathogens, namely trichomonas vaginalis, streptococcus pneumoniae, neisseria gonorrhoeae, chlamydia trachomatis, ureaplasma parvum, u. urealyticum, gardnerella vaginalis, haemophilus influenzae, herpes simplex virus type 1 (hsv1) and hsv2, ... | 2009 | 19357202 |
| prevention of genital herpes simplex virus type 1 and 2 disease in mice immunized with a gd-expressing dominant-negative recombinant hsv-1. | cj9-gd is a novel herpes simplex virus (hsv) type 1 recombinant virus that is completely replication-defective, expresses high-levels of hsv-1 major antigen glycoprotein d (gd), and can function in trans to inhibit replication of wild-type hsv-1 and hsv-2 in co-infected cells. here, we show that immunization with cj9-gd elicits strong and long-lasting humoral and th1-like cellular immune responses against both hsv-1 and hsv-2. mice immunized with cj9-gd exhibited significant reductions in the ex ... | 2009 | 19357711 |
| [the influence of chronic viral infections on tuberculosis]. | the influence of chronic viral infections (cvi) on tuberculosis (tb) was investigated in 117 patients with mix infection (hhv-2 - human herpes virus-2) and tb; 6 patients with mix infection (cmv - cytomegalovirus) and tb; 22 patients with mix infection (individuals with chronic hepatitis c virus (hcv) infection and tb. the control group was composed of 33 tb patients without cvi. increased rates of atypical tuberculosis, reactivation of latent tuberculosis have been reported among patients with ... | 2009 | 19359724 |
| estimating the public health impact of the effect of herpes simplex virus suppressive therapy on plasma hiv-1 viral load. | trials of herpes simplex virus (hsv) suppressive therapy among hsv-2/hiv-1-infected individuals have reported an impact on plasma hiv-1 viral loads (pvls). our aim was to estimate the population-level impact of suppressive therapy on female-to-male hiv-1 sexual transmission. | 2009 | 19367154 |
| circumcision's place in the vicious cycle involving herpes simplex virus type 2 and hiv. | 2009 | 19367793 | |
| multiple viral genome search in endolabyrinthic fluids of profoundly deaf patients: possible cytomegalovirus intracochlear reactivation. | the cause of about 30% of bilateral sensorineural hearing loss (snhl) is still unknown. a viral etiology is among the most frequently proposed ones and the supposed diagnosis is only based upon few clinical and laboratory data. the detection of viral presence within a damaged compartment may represent a way to supply interesting data for confirmation of viral etiology and to explain pathogenic mechanisms. | 2009 | 19372646 |
| high hiv and ulcerative sexually transmitted infection incidence estimates among men who have sex with men in peru: awaiting for an effective preventive intervention. | in the andean region, hiv and sexually transmitted infections (sti) are most prevalent among men who have sex with men (msm), but incidence estimates and associated factors have never been prospectively assessed. | 2009 | 19384102 |
| pediatric herpes simplex virus keratitis. | to report the clinical characteristics and visual outcomes of pediatric herpes simplex virus (hsv) keratitis. | 2009 | 19387223 |
| meta-analytical studies on the epidemiology, prevention, and treatment of human immunodeficiency virus infection. | since the beginning of the epidemic, extensive research has been conducted in the field of hiv infection. original research and subsequent meta-analyses have contributed to a better understanding of the disease. epidemiologic research has shown, for example, that male circumcision reduces the risk of female-to-male transmission. nevertheless, the question whether circumcision confers protection against hiv transmission in msm remains open. studies have shown a positive correlation between hiv an ... | 2009 | 19393910 |
| characteristics of hiv-1 discordant couples enrolled in a trial of hsv-2 suppression to reduce hiv-1 transmission: the partners study. | the partners hsv-2/hiv-1 transmission study (partners study) is a phase iii, placebo-controlled trial of daily acyclovir for genital herpes (hsv-2) suppression among hiv-1/hsv-2 co-infected persons to reduce hiv-1 transmission to their hiv-1 susceptible partners, which requires recruitment of hiv-1 serodiscordant heterosexual couples. we describe the baseline characteristics of this cohort. | 2009 | 19404392 |
| does psychosocial stress predict symptomatic herpes simplex virus recurrence? a meta-analytic investigation on prospective studies. | previous psychological studies have paid extensive attention to the association between psychosocial stress and symptomatic herpes simplex virus (hsv) recurrence, but subsequent research has been conducted and conflicting findings have been published. we aimed to quantify the longitudinal association between psychosocial stress and recurrent hsv in the contemporary literature. we searched medline; psycinfo; web of science; pubmed up to march 2009, and included prospective studies that investigat ... | 2009 | 19409481 |
| phosphonate analogues of cyclopropavir phosphates and their e-isomers. synthesis and antiviral activity. | z- and e-phosphonate analogues 12 and 13 derived from cyclopropavir and the corresponding cyclic phosphonates 14 and 15 were synthesized and their antiviral activity was investigated. the 2,2-bis(hydroxymethylmethylenecyclopropane acetate (17) was transformed to tetrahydropyranyl acetate 18. deacetylation gave intermediate 19 which was converted to bromide 20. alkylation with diisopropyl methylphosphonate afforded after protecting group exchange (21 to 22) acetylated phosphonate intermediate 22. ... | 2009 | 19410465 |
| polymorphisms of mtdna control region in tunisian and moroccan populations: an enrichment of forensic mtdna databases with northern africa data. | current forensic mitochondrial (mt)dna databases are limited in representative population data of african origin. we investigated hvs-i/hvs-ii sequences of 120 tunisian and moroccan healthy male donors applying stringent quality criteria to assure high quality of the data and phylogenetic alignment and notation of the sequences. among 64 tunisians, 56 different haplotypes were observed and the most common haplotype (16187t 16189c 16223t 16264t 16270t 16278t 16293g 16311c 73g 152c 182t 185t 195c ... | 2009 | 19414164 |
| isolation of sulfated galactan from codium fragile and its antiviral effect. | a sulfated galactan (fg) was isolated from the green alga, codium fragile. chemical analysis revealed that fg mainly consisted of d-galactose with pyruvic acid (12.3%) and sulfate (11.0%). methylation and nmr analyses showed that fg was composed of -->3)-beta-d-galp-(1-->, beta-d-galp-(1--> and -->3,6)-beta-d-galp-(1--> residue. in addition, pyruvic acid was suggested to be present as (1'-carboxy)-ethylidene cyclic ketal at o-3 and o-4 of non-reducing terminal galactose residues, whereas sulfate ... | 2009 | 19420760 |
| in vitro anti-herpetic activity of an aqueous extract from the plant phyllanthus orbicularis. | the herpesviridae includes at least eight viral species pathogenic for humans, responsible for a wide variety of clinical symptoms. the lack of an effective vaccine and the moderate to high toxicity of the available synthetic anti-herpes compounds emphasises the need for new inhibitors. several phyllanthus genus (euphorbiaceae) members have been widely used in traditional medicine and their biological properties have been intensely studied. in this study we investigated the in vitro antiviral ac ... | 2009 | 19423312 |
| the herpes simplex virus-induced demise of keratinocytes is associated with a dysregulated pattern of p63 expression. | p63 plays a pivotal role in the development and maintenance of stratified epithelial tissues. in an effort to gain insight into the pathogenic mechanisms of skin infections caused by hsv-1 and hsv-2, we determined the patterns of p63 expression in primary keratinocytes and in the hacat cell line. the levels of deltanp63alpha and a 50kda p73 isoform were decreased, bax-alpha remained unaffected, while the expressions of the bax-beta, tap63gamma and a 44.5kda p73 isoform were highly increased in b ... | 2009 | 19427396 |
| an exopolysaccharide produced by geobacillus thermodenitrificans strain b3-72: antiviral activity on immunocompetent cells. | the immunomodulatory and antiviral effects of an extracellular polysaccharide (eps-2), produced by a strain of geobacillus thermodenitrificans isolated from a shallow marine vent of vulcano island (italy), were evaluated. in the present study, we show for the first time that eps-2 treatment hinder hsv-2 replication in human peripheral blood mononuclear cells (pbmc) but not in wish cells. in fact, high levels of ifn-alpha, il-12, ifn-gamma, tnf-alpha, il-18 were detected in supernatants of eps-2 ... | 2009 | 19428560 |
| analysis of varicella-zoster virus and herpes simplex virus in various clinical samples by the use of different pcr assays. | rapid and reliable detection of varicella-zoster virus (vzv) and herpes simplex virus type 1 (hsv-1) and -2 (hsv-2) is of clinical significance in immunocompromised patients and patients with infections of the central nervous system. this paper describes the detection of vzv and hsv using the commercially available affigene vzv and affigene hsv 1/2 tracer kits in comparison to "in-house" polymerase chain reaction (pcr) assays. for sample preparation, qiagen (hilden, germany) and affigene (cephei ... | 2009 | 19433110 |
| disentangling contributions of reproductive tract infections to hiv acquisition in african women. | : to estimate the effects of reproductive tract infections (rtis) on hiv acquisition among zimbabwean and ugandan women. | 2009 | 19434010 |
| therapeutic effect of meliacine, an antiviral derived from melia azedarach l., in mice genital herpetic infection. | since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of melia azedarach l., a plant used in traditional medicine in india for the treatment of several diseases, has been studied. meliacine exhibits a potent antiviral effect against several viruses without displaying cytotoxicity. the purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of ... | 2009 | 19441066 |
| [benign recurrent lymphocytic meningitis from herpes simplex virus type 2]. | 2009 | 19445858 | |
| [culture of hsv-2 and cloning of specific fragment of the gg-2 gene]. | to clone the glycoprotein g gene and its specific fragment with high conservation and antigenicity by culturing and amplifying herpes simplex virus type 2 and extracting its whole genome. | 2009 | 19452693 |
| hsv2 acute retinal necrosis: diagnosis and monitoring with quantitative polymerase chain reaction. | to describe a case of hsv2 acute retinal necrosis (arn) diagnosed and monitored with quantitative polymerase chain reaction (pcr) in ocular fluids. | 2009 | 18297242 |
| glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin. | lactoferrin has been recognized as a potent inhibitor of human herpetic viruses, such as herpes simplex type 1 (hsv-1) and 2 (hsv-2). in particular, bovine lactoferrin (blf) has been found to prevent viral infection by binding to heparan sulphate (hs) glycosaminoglycans (gags) that in turn can act as cell receptors for human herpetic viruses. in this study we further investigate the mechanism of inhibiting activity of both human lactoferrin (hlf) and blf against hsv-2. the antiviral effect of th ... | 2009 | 18534197 |
| prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters. | to determine the prevalence of herpes viruses in the semen of an asymptomatic male cohort with and without infertility problems and its association with altered semen parameters. | 2009 | 18565516 |
| comparison of intramuscular and footpad subcutaneous immunization with dna vaccine encoding hsv-gd2 in mice. | herpes simplex virus type 2 is the most common infectious agent in humans that causes genital herpes disease and vaccination is a desirable method to prevent herpes infections. an effective therapeutic vaccine will need to elicit virus-specific immune responses. the route of immunization has important role in immune responses. in this study, dna vaccine encoding glycoprotein d of herpes simplex virus type 2 (hsv-gd2) was prepared and injected via intramuscular and footpad routes to determine the ... | 2009 | 18571235 |
| seroprevalence of sexually transmitted viruses in the tribal population of central india. | to determine the seroprevalence of human immunodeficiency virus (hiv), hepatitis b and c viruses (hbv, hcv), and herpes simplex virus type 2 (hsv-2) in the tribal population of central india. | 2009 | 18573674 |
| frosted branch angiitis secondary to herpes simplex virus infection progressing to acute retinal necrosis. | to describe a case of frosted branch angiitis secondary to herpes simplex virus type 2 infection that progressed to acute retinal necrosis. | 2009 | 25390834 |
| innate and adaptive immune responses to herpes simplex virus. | immune responses against hsv-1 and hsv-2 are complex and involve a delicate interplay between innate signaling pathways and adaptive immune responses. the innate response to hsv involves the induction of type i ifn, whose role in protection against disease is well characterized in vitro and in vivo. cell types such as nk cells and pdcs contribute to innate anti-hsv responses in vivo. finally, the adaptive response includes both humoral and cellular components that play important roles in antivir ... | 2009 | 21994578 |
| [seroepidemiological surveys of non vaccine-preventable diseases and their interest in public health]. | seroepidemiological surveys are epidemiological studies carried out by the use of serum tests to detect infection; they can be applied to infections in general and to vaccine-preventable diseases in particular. among other applications, seroepidemiological studies are useful for determining groups at risk for a specific disease; evaluating transmission mechanisms; and determining population groups who are critical in maintaining the transmission of infectious agents. we analysed the results of s ... | 2009 | 20111813 |
| [hsv-1 and hsv-2 seropositivity rates in pregnant women admitted to izmir ataturk research and training hospital, turkey]. | in this study, the seropositivity rates of herpes simplex virus (hsv) types 1 and 2, and their distribution according to the age groups in the sera of asymptomatic pregnant women who were admitted to gynecology and obstetrics clinics of izmir ataturk research and training hospital for routine control, were investigated. igg and igm antibodies specific for hsv-1 and hsv-2 were screened by commercial elisa kits (radim spa-pomezia, italia). total igg seropositivity rates for hsv-1 and hsv-2 were fo ... | 2009 | 20084927 |
| successful increase in contraceptive uptake among kenyan hiv-1-serodiscordant couples enrolled in an hiv-1 prevention trial. | to evaluate a multipronged approach to promote dual contraceptive use by women within heterosexual hiv-1-serodiscordant partnerships. | 2009 | 20081393 |
| herpes simplex virus infections in solid organ transplant recipients. | 2009 | 20070669 | |
| herpesviridae and novel inhibitors. | herpesviridae comprises a large family of double-stranded dna viruses that infect both animals and humans. eight herpesviruses are known to infect humans: herpes simplex virus type-1 and -2, varicella zoster virus, human cytomegalovirus, epstein-barr virus, human herpesvirus 6 type-a and -b, human herpesvirus type-7 and -8 or kaposi's sarcoma virus. despite the fact that the past two decades have been evolutionary in the development of antiviral agents, therapeutic choices are restricted by limi ... | 2009 | 20032535 |
| susceptibility to genital herpes as a biomarker predictive of increased hiv risk: expansion of a murine model of microbicide safety. | a crucial gap in the development of microbicides for hiv prevention is the absence of models predictive of safety. previous studies have demonstrated an increased susceptibility to genital herpes in mice following repeated applications of nonoxynol-9 (n-9). this study was designed to explore the underlying mechanisms, focusing on the effects that n-9 has on genital tract epithelium and to apply this expanded model to evaluate the safety of microbicides that have been advanced to clinical trials. | 2009 | 20032541 |
| [mechanisms of chlamydia trachomatis and herpes simplex virus persistence during viral-bacterial infection]. | possible mechanisms of persistence on the example of chlamydia trachomatis in conditions of herpes simplex virus type 2 (hsv-2) superinfection in vitro and in vivo are described. emergence of persisting forms of chlamydia as well as factors influencing on this process are considered. contemporary views on pathogenesis of viral-bacterial infection with hsv-2 and c. trachomatis as well as interactions of the agents with local immunity factors are described. it was suggested that there are signalin ... | 2009 | 20066779 |
| effect of combinations of antiviral drugs on herpes simplex encephalitis. | 2-phenylamino-6-oxo-9-(4-hydroxybutyl)purine (hbpg) is a thymidine kinase inhibitor that prevents encephalitic death in mice caused by herpes simplex virus (hsv) types 1 and 2, although its potency is somewhat less than that of acyclovir (acv). the present study was undertaken to determine the effect of combinations of hbpg and either acv, phosphonoformate (pfa), or cidofovir (cdf) against hsv encephalitis. balb/c mice were given ocular infections with hsv-1 or hsv-2, and treated twice daily int ... | 2009 | 20054446 |
| [relationship between primary ocular adnexal mucosa-associated lymphoid tissue lymphoma and eye infection]. | to study the role of pathogenic microorganisms commonly associated with chronic eye disease, including chlamydia psittaci, chlamydia trachomatis, chlamydia pneumoniae, herpes simplex virus (hsv) type 1 and type 2, and adenovirus type 8 and type 19, in the development of primary ocular adnexal mucosa-associated lymphoid tissue (malt) lymphoma in chinese patients. | 2009 | 20021960 |
| discussion and revision of the mathematical modeling tool described in the previously published article "modeling hiv transmission risk among mozambicans prior to their initiating highly active antiretroviral therapy". | mathematical models are increasingly used in social and behavioral studies of hiv transmission; however, model structures must be chosen carefully to best answer the question at hand and conclusions must be interpreted cautiously. in pearson et al. (2007), we presented a simple analytically tractable deterministic model to estimate the number of secondary hiv infections stemming from a population of hiv-positive mozambicans and to evaluate how the estimate would change under different treatment ... | 2009 | 20024742 |
| a macaque model to study vaginal hsv-2/immunodeficiency virus co-infection and the impact of hsv-2 on microbicide efficacy. | herpes simplex virus type-2 (hsv-2) infection enhances the transmission and acquisition of human immunodeficiency virus (hiv). this occurs in symptomatic and asymptomatic stages of hsv-2 infection, suggesting that obvious herpetic lesions are not required to increase hiv spread. an animal model to investigate the underlying causes of the synergistic action of the two viruses and where preventative strategies can be tested under such complex physiological conditions is currently unavailable. | 2009 | 20011586 |
| sexually transmitted infections among hiv-1-discordant couples. | more new hiv-1 infections occur within stable hiv-1-discordant couples than in any other group in africa, and sexually transmitted infections (stis) may increase transmission risk among discordant couples, accounting for a large proportion of new hiv-1 infections. understanding correlates of stis among discordant couples will aid in optimizing interventions to prevent hiv-1 transmission in these couples. | 2009 | 20011596 |
| association between hsv-2 and hiv serostatus in pregnant women of known hiv serostatus attending mulago hospital antenatal clinic, kampala, uganda. | studies show that stis such as hsv-2 increase the probability of hiv-1 acquisition and enhance transmission by increasing susceptibility and infectiousness respectively. the objective of this study was to compare the proportion of hsv-2 in hiv-positive and hiv-negative pregnant mothers attending the antenatal clinic in mulago teaching hospital in kampala, uganda. | 2009 | 20009284 |
| new concepts in understanding genital herpes. | herpes simplex virus (hsv)-2 is a lifelong infection that causes recurrent genital ulcers and, rarely, disseminated and visceral disease. hsv-1 infection is an increasingly important cause of genital ulcers. hsv infections are the most common cause of genital ulcers in adults, but acquisition and chronic infection are more commonly asymptomatic than symptomatic. both the symptomatic and asymptomatic forms of hsv are of clinical consequence for several reasons. hsv-2 infection enhances hiv-1 acqu ... | 2009 | 19857385 |
| [establishment and clinical application of a new real time pcr assay for simultaneous detection of human herpesvirus-6a and human herpesvirus-6b]. | human herpesvirus 6 (hhv-6) isolates are classified into two variants, hhv-6a and hhv-6b, based on distinct genetic, antigenic and biological characteristics. hhv-6 has been associated with encephalitis in children recently. this study aimed to establish a real time pcr assay for simultaneous detection of the two subtypes of hhv-6, and apply this new assay to children with suspected encephalitis, then analyze the relationship between the infection with hhv-6 and encephalitis in children. | 2009 | 19951517 |
| amphipathic dna polymers exhibit antiviral activity against systemic murine cytomegalovirus infection. | phosphorothioated oligonucleotides (ps-ons) have a sequence-independent, broad spectrum antiviral activity as amphipathic polymers (aps) and exhibit potent in vitro antiviral activity against a broad spectrum of herpesviruses: hsv-1, hsv-2, hcmv, vzv, ebv, and hhv-6a/b, and in vivo activity in a murine microbiocide model of genital hsv-2 infection. the activity of these agents against animal cytomegalovirus (cmv) infections in vitro and in vivo was therefore investigated. | 2009 | 19954538 |
| [association between hsv-2 infection and serum anti-rat brain antibodies in patients with autism]. | some cases of autism could be linked to viral infections able to induce autoimmune mechanisms directed against the encephalon. neurothophic virus infections in animals are associated with clinical signs that are similar to those observed in neurodevelopment disorders. thus, in this study, we determined the co-existence of antibodies against nerve tissue and viruses with neurothophic competence (hsv-1/2, epstein-barr-ebv, cytomegalovirus, measles and rubella) in serum of forty autistic children a ... | 2009 | 19961054 |
| decreasing prevalence of herpes simplex virus-2 antibodies in selected groups of women in sweden. | high estimates of herpes simplex virus-2 (hsv-2) seroprevalence have been reported for women who were pregnant in sweden in the 1980s, probably reflecting sexual risk-taking during the 1960s and 1970s. the aim of the present study was to evaluate the hsv-2 seroprevalence in pregnant women and in the female attendees at a clinic for sexually transmitted infections in sweden at the beginning of the 21st century and to compare the results with those of earlier swedish studies. sera were collected d ... | 2009 | 19997695 |
| seroprevalence of hiv, hsv-2, and treponema pallidum in the kosovarian population. | the objective of this study was to evaluate the seroprevalence of infection with hiv, herpes simplex virus type 2 (hsv-2), and treponema pallidum (tp) in a kosovarian population. a cross-sectional study was performed in peja, kosovo, from january to march 2005, among 1285 persons recruited at the peja hospital. the seroprevalence of hiv, hsv-2, and tp was evaluated, and the viral correlates for each infection were analysed. no hiv-positive cases were found. the seroprevalence of hsv-2 was 20.2%. ... | 2009 | 20001281 |
| viral hepatitis, hiv, human herpes virus and treponema pallidum infection in haemodialysis patients from kosovo, 2005. | the serological status of hepatitis viruses and other infectious diseases in the 66 dialysed patients of one haemodialysis unit in kosovo were studied, comparing the data with a large group of blood donors and out-patients. all dialysed patients were hepatitis a virus (hav) positive. prevalence of hepatitis b surface antigen (hbsag), hepatitis b surface antibodies (anti-hbs), and hepatitis b core antibodies (anti-hbc) was 14 of 66, 21% (95% confidence interval (ci): 12-33%), 5 of 66, 8% (95%ci: ... | 2009 | 20003903 |
| immunology: a helpers' guide to infection. | 2009 | 19940905 | |
| epidemiology of herpes simplex virus types 2 and 1 amongst men who have sex with men attending sexual health clinics in england and wales: implications for hiv prevention and management. | the objective was to investigate herpes simplex virus (hsv) epidemiology amongst hiv-positive and hiv-negative men who have sex with men (msm) in england and wales. unlinked anonymous sera from 3,968 msm attending 12 sexual health clinics in 2003 were tested for hiv, hsv-2 and hsv-1 antibodies. fifty-five percent of hiv-positive msm were hsv-2-seropositive, compared to 17% of hiv-negative msm (adj rr: 2.14 [ci: 1.92-2.37]). amongst hiv-positive individuals, there was no significant difference in ... | 2009 | 19941804 |
| relative hiv resistance in kenyan sex workers is not due to an altered prevalence or mucosal immune impact of herpes simplex virus type 2 infection. | chronic infection by herpes simplex virus type 2 (hsv-2) increases hiv susceptibility, perhaps due to hsv-2-associated increases in activated mucosal immune cells. a small number of kenyan female sex workers (fsws) exhibit relative hiv resistance. we examined whether relative hiv resistance was related to differences in the prevalence or mucosal immune impact of hsv-2. participants were recruited from an open cohort of hiv-uninfected fsws in nairobi, kenya. women who had been practicing sex work ... | 2009 | 19925401 |
| herpes simplex virus sepsis and acute liver failure. | acute liver failure is a life threatening disease mostly triggered by drug-induced or toxic liver damage or viral hepatitis. herpes simplex virus (hsv) hepatitis is rare and accounts for only 1% of all acute liver failures. the importance of hsv-induced acute liver failure is based on its extremely severe clinical course with lethality rates of almost 75%. hsv hepatitis is just one of several clinical manifestations of hsv sepsis leading more frequently to encephalitis, pneumonia and esophagitis ... | 2009 | 19930315 |
| prevalence of sexually transmitted infections among female adolescents aged 14 to 19 in the united states. | most young women initiate sexual activity during adolescence; risk for sexually transmitted infections (stis) accompanies this initiation. in this study we estimated the prevalence of the most common stis among a representative sample of female adolescents in the united states. | 2009 | 19933728 |
| effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for hiv prevention: analyses from the rakai trials. | randomized trials show that male circumcision (mc) reduces the incidence of hiv and herpes simplex virus type 2 (hsv-2) infections, and symptomatic genital ulcer disease (gud). we assessed the role of gud and hsv-2 in the protection against hiv afforded by mc. | 2009 | 19936044 |
| gammadelta t lymphocytes producing ifngamma and il-17 in response to candida albicans or mycobacterial antigens: possible implications for acute and chronic inflammation. | t lymphocytes bearing the gammadelta t cell receptor are known to play an important role in the first-line defense against viral, bacterial and fungal pathogens. two main subsets of gammadelta t cells are known, showing distinct functional behaviour: vdelta2 t lymphocytes, circulating in the peripheral blood, are involved in the response to mycobacterial infections and certain viruses, including coxsakie virus b3 and herpes simplex virus type 2. vdelta1 t cells are resident in the mucosal-associ ... | 2009 | 19903136 |
| fsl-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental hsv-2 infection. | herpes simplex virus type 2 (hsv-2) is a leading cause of genital ulceration that can predispose individuals to an increased risk of acquiring other sexually transmitted infections. there are no approved hsv-2 vaccines and current suppressive therapies require daily compound administration that does not prevent all recurrences. a promising experimental strategy is the use of toll-like receptor (tlr) agonists to induce an innate immune response that provides resistance to hsv-2 infection. previou ... | 2009 | 19903337 |
| childhood kikuchi-fujimoto disease. | to investigate the clinical features of kikuchi-fujimoto disease (kfd) and the relationship between viral infection and this disease in children will be better as kikuchi-fujimoto disease (kfd) is a lymphadenopathy. the aim of study is to investigate the clinical features of kfd and the relationship. the age, gender, clinical features and aetiopathogenesis of 36 chinese children with fkd were reviewed, and the viral antigens were detected. mean age was 10.1 +/- 2.8 yr with a male to female ratio ... | 2009 | 19904514 |
| herpes simplex virus in african american heterosexual males: the roles of age and male circumcision. | background:: male circumcision is protective against human immunodeficiency virus (hiv) and select other stis. the protective role of male circumcision in genital herpes simplex virus (hsv) infection and disease, however, remains controversial. methods:: we evaluated data from a sample of heterosexual black men attending a sexually transmitted diseases clinic to determine if circumcision status influenced hsv-1 and hsv-2 seroprevalence, clinical genital disease, or asymptomatic shedding. consent ... | 2009 | 19910861 |
| circumcision and risk of sexually transmissible infections in a community-based cohort of hiv-negative homosexual men in sydney, australia. | circumcision status was examined as an independent risk factor for sexually transmissible infections (stis) in the health in men cohort of homosexual men in sydney. | 2009 | 19911990 |
| prevalence of trichomonas vaginalis infection among young reproductive age women in india: implications for treatment and prevention. | trichomonas vaginalis infection is the most common curable sexually transmissible infection (sti) worldwide. the present study describes the burden and correlates of t. vaginalis infection among young reproductive age women in mysore, india. | 2009 | 19917204 |
| aging promotes neutrophil-induced mortality by augmenting il-17 production during viral infection. | morbidity and mortality associated with viral infections increase with age, although the underlying mechanisms are unclear. here, we investigated whether aging alters inflammatory responses during systemic viral infection and thereby contributes to virus-induced death. we found that infection of aged mice with systemic herpes viruses led to rapid increases in serum il-17, neutrophil activation, and mortality due to hepatocyte necrosis. in contrast, all young mice survived infection, displaying w ... | 2009 | 19917499 |
| distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck. | the distribution of the neurotropic alphaherpesviruses-herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) and varicella zoster virus (vzv)-was determined in autonomic and sensory ganglia of the head and neck obtained from formalin-fixed human cadavers. hsv-1 and vzv dna were found in 18 of 58 and 16 of 58 trigeminal, 23 of 58 and 11 of 58 pterygopalatine, 25 of 60 and 14 of 60 ciliary, 25 of 48 and 11 of 48 geniculate, 15 of 50 and 8 of 50 otic, 14 of 47 and 4 of 47 submandibular, 18 of 58 a ... | 2009 | 19919304 |
| mollaret meningitis may be caused by reactivation of latent cerebral toxoplasmosis. | mollaret meningitis (mm) occurs mainly in females and is characterized by recurrent episodes of headache, transient neurological abnormalities, and the cerebrospinal fluid containing mononuclear cells. hsv-2 was usually identified as the causative agent. recently, we found that recurrent headaches in non-hiv-infected subjects were due to acquired cerebral toxoplasmosis (ct). the aim of the study was therefore to focus on molecular pathomechanisms that may lead to reactivation of latent ct and ma ... | 2009 | 19922380 |
| role of hsv-2 suppressive therapy for hiv prevention. | 2009 | 19895212 | |
| cd8(+) t lymphocyte mobilization to virus-infected tissue requires cd4(+) t-cell help. | cd4(+) t helper cells are well known for their role in providing critical signals during priming of cytotoxic cd8(+) t lymphocyte (ctl) responses in vivo. t-cell help is required for the generation of primary ctl responses as well as in promoting protective cd8(+) memory t-cell development. however, the role of cd4 help in the control of ctl responses at the effector stage is unknown. here we show that fully helped effector ctls are themselves not self-sufficient for entry into the infected tiss ... | 2009 | 19898495 |
| isolation of acridone alkaloids and n-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives from glycosmis parva and their anti-herpes simplex virus activity. | six acridone alkaloids including a new glycosparvarine (1), three limonoids, and four n-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives including two new species, (+)-s-deoxydihydroglyparvin (10) and (+)-s-deoxytetrahydroglyparvin (11), were isolated from the branches and the leaves of glycosmis parva craib collected in the east of thailand. antiviral activity evaluation of isolates against herpes simplex virus (hsv) type 1 and 2 disclosed that two acridone ... | 2009 | 19881276 |
| [vitaherpavac is the first russian herpes simplex virus vaccine obtained on the vero b continuous cell line]. | vitaherpavac, a dry inactivated herpes simplex virus (hsv) culture vaccine, has been obtained, by using the vero b continuous cell line as a substrate for accumulation of herpes simplex virus types 1 (us strain) and 2 (vn strain). vitaherpavac and the similar vaccine herpovax made by the research institute of vaccines and sera, saint petersburg (for which preparation a primary trypsinized chick embryo cell culture used as a substrate for accumulation of hsv types 1 and 2), underwent comparative ... | 2009 | 19882901 |
| hsv type 2 infection increases hiv dna detection in vaginal tissue of mice expressing human cd4 and ccr5. | the goal of this study was to develop an in vivo murine model that can be used to study the influence of hsv-2 on hiv infection. mice expressing transgenes for human cd4, ccr5, and cyclin t1 were infected intravaginally with hsv-2 and 3-7 days later infected with hiv. hiv dna was detected by real-time pcr. the frequency of detection of hiv dna was significantly higher (65%) in vaginal tissue of hsv-2-infected mice compared to mock-infected mice (35%) when hiv was given 3 days after hsv-2. hsv-2- ... | 2009 | 19886831 |
| a quick and parallel analytical method based on quantum dots labeling for torch-related antibodies. | quantum dot is a special kind of nanomaterial composed of periodic groups of ii-vi, iii-v or iv-vi materials. their high quantum yield, broad absorption with narrow photoluminescence spectra and high resistance to photobleaching, make them become a promising labeling substance in biological analysis. here, we report a quick and parallel analytical method based on quantum dots for torch-related antibodies including toxoplasma gondii, rubella virus, cytomegalovirus and herpes simplex virus type 1 ... | 2009 | 20652102 |
| inhibition of herpes simplex virus type 2 by vaginal lactobacilli. | the protective effect of selected vaginal lactobacillus strains (l. brevis cd2, l. salivarius fv2, l. plantarum fv9) towards herpes simplex virus type 2 (hsv-2) infection in vitro has been analyzed. living bacterial cells affect different steps of virus multiplication. the effect on the early phases of virus infection appeared related to the bacterial adhesive potential to the cell membrane while all the strains strongly reduced intracellular events of virus multiplication. the anti hsv-2 activi ... | 2009 | 20224147 |
| diagnosis of neurological herpesvirus infections: real time pcr in cerebral spinal fluid analysis. | human herpesviruses (hhvs) cause many serious acute and persistent central nervous system (cns) disorders. because these infections manifest with various, often non-specific, symptoms and signs, and because specific therapy is often available, accurate diagnosis is essential. cerebrospinal fluid (csf) from 146 patients with acute meningitis or meningoencephalitis and 9 with "other neurological disorders" were analyzed by using an automatic system for nucleic acid extraction and quantitative real ... | 2009 | 20128439 |
| left out but not forgotten: should closer attention be paid to coinfection with herpes simplex virus type 1 and hiv? | herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) are among the most common coinfections seen in individuals infected with hiv-1. most research on hsv-hiv coinfection has focused on hsv-2, and in particular, on its impact on hiv transmission. hsv-2 is associated with micro- and macroulcerations in genital mucosal surfaces, increased numbers of hiv target cells in genital mucosal tissue and increases in plasma hiv viral load of up to 0.5 log(10) copies/ml, such that hsv-2 infection increases ... | 2009 | 20190881 |
| [study on herpes simplex virus 2 infection and risky sexual behavior among hiv-infected patients in a county of yunnan province.]. | to explore the sero-prevalence and risk factors for herpes simplex virus 2 (hsv-2) infection and unprotected sexual behavior in an ethnically diverse population of hiv-infected subjects in a county of yunnan province. | 2009 | 20193582 |
| frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. | herpes simplex virus-2 (hsv-2) is a sexually transmitted infection that is the leading cause of genital ulcers worldwide. infection is life long and is characterized by repeated asymptomatic and symptomatic shedding episodes of virus that are initiated when virus is released from neurons into the genital tract. the pattern of hsv-2 release from neurons into the genital tract is poorly understood. we fit a mathematical model of hsv-2 pathogenesis to curves generated from daily quantification of h ... | 2009 | 20161655 |
| sexually transmitted diseases and anorectum. | sexually transmitted diseases (std) are a major public health problem because their incidence is increasing worldwide despite prevention campaigns and because they raise the risk of hiv infection. anorectal localisations of std are common among men who have sex with men (msm) but can also be seen among heterosexuals (men or women). transmission of such infections is due to anal sex or to other sexual behaviours like "fisting". although some pathogens (like human papillomavirus-hpv) are common in ... | 2009 | 20163035 |
| verbascoside isolated from lepechinia speciosa has inhibitory activity against hsv-1 and hsv-2 in vitro. | verbascoside has been isolated form l. speciosa after several different chromatographic methods. after its purification, the structure has been unequivocally established using modern spectroscopic techniques. as for the antiviral activity, the maximum non toxic concentration has been established and this concentration has been used in the anti herpes assay, in vitro. mechanism of action for this molecule regarding the anti-herpes activity has been studied encompassing the following assays: viruc ... | 2009 | 20120109 |
| antiviral activity of ancient system of ayurvedic medicinal plant cissus quadrangularis l. (vitaceae). | partially purified methanolic extract of cissus quadrangularis (belonging to vitaceae member, south indian medicinal plant) have been explored for antiviral activity and their phytochemical characterisation. in vitro antiviral activity against hsv type1 and 2, and vero cells at non-cytotoxic concentration were determined. hsv1 and hsv2 showed more sensitivity against the partially purified compound. phytochemical analysis showed the presence of the steroids and terpenoids. | 2009 | 25206252 |
| an estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. | to estimate the global prevalence and incidence of herpes simplex virus type 2 (hsv-2) infection in 2003. | 2008 | 18949218 |
| herpes simplex virus viremia during primary genital infection. | primary genital herpes simplex virus (hsv) infection is commonly associated with systemic symptoms. a systematic evaluation of hsv viremia during primary genital infection has not been performed previously. plasma samples from adults with a first clinical episode of genital hsv infection were assayed for hsv dna by polymerase chain reaction. one hundred sixty-four adults had confirmed primary genital hsv infection. of these, 40 (24%) had hsv dna detected in plasma. thirty-seven (93%) of 40 were ... | 2008 | 18471083 |
| inhibition of herpes simplex virus types 1 and 2 in vitro infection by sulfated derivatives of escherichia coli k5 polysaccharide. | herpes simplex virus type 1 (hsv-1) and hsv-2 are neurotropic viruses and common human pathogens causing major public health problems such as genital herpes, a sexually transmitted disease also correlated with increased transmission and replication of human immunodeficiency virus type 1 (hiv-1). therefore, compounds capable of blocking hiv-1, hsv-1, and hsv-2 transmission represent candidate microbicides with a potential added value over that of molecules acting selectively against either infect ... | 2008 | 18573926 |
| facile biocatalytic access to 9-fluorenylmethyl polyglycosides: evaluation of antiviral activity on immunocompetent cells. | the biological activities of a series of mono- and oligosaccharides (beta-xylosides and alpha-glucosides) of 9-fluorenylmethanol were investigated together with mono-beta-galactoside and beta-glucoside of this aglycone, produced by biocatalytic routes. by using marine glycoside hydrolases and inexpensive donors such as maltose or xylan, access to mono-alpha-glucoside or mono-beta-xyloside of 9-fluorenylmethanol was obtained. additionally, interesting polyglycoside derivatives were isolated. biol ... | 2008 | 18576391 |
| seroprevalence and risk factors associated with herpes simplex virus infection among pregnant women. | to estimate the type-specific seroprevalence and identify the risk factors associated with herpes simplex virus (hsv)-2 infection in pregnant women in bucharest, romania. | 2008 | 18576929 |
| acute and recurrent viral meningitis. | acute viral meningitis is the most common infection of the central nervous system. most cases occur in children and young adults and are due to enteroviruses. although the common causes of acute viral meningitis still lack treatment with an effective antiviral agent, management of patients is changing because of better and more rapid diagnostic tests to determine the exact viral etiology. these tests reduce the cost of workups and shorten hospitalizations. recurrent meningitis is less common, wi ... | 2008 | 18579020 |
| clients of female sex workers in gonaives and st-marc, haiti characteristics, sexually transmitted infection prevalence and risk factors. | few data exist on the role of clients of female sex workers (fsws) in sti transmission. this study examined sociodemographic characteristics, risk behaviors, and sti prevalence among clients of fsws in haiti. | 2008 | 18580821 |
| comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. | this study was performed to compare nested-polymerase chain reaction (pcr) with viral culture as a diagnostic tool for genital herpes simplex virus (hsv) infection in a sexually transmitted infection (sti) clinic in singapore. | 2008 | 18581019 |
| herpes simplex virus 2 infection: a risk factor for hiv infection in heterosexuals. | genital ulcerative disease is one of the risk factors for acquisition of hiv. as hsv-2 infection is currently the most common cause of genital ulcerative disease, it acts as a potential risk factor for hiv infection. the present study was undertaken to know the seroprevalence of antibodies to hsv-2 in hiv seropositive individuals and in the general population, and to ascertain if hsv-2 is a risk factor for developing hiv infection. | 2008 | 18583789 |
| rapidly increasing incidence of kaposi's varicelliform eruption in patients with atopic dermatitis. | 2008 | 18583798 | |
| roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (hiv-1)-induced immunosuppression on genital and plasma hiv-1 levels. | few longitudinal studies have described the interactions between reactivation of herpes simplex virus type 2 (hsv-2) infection (hereafter, "hsv-2 reactivation") and genital and systemic replication of human immunodeficiency virus type 1 (hiv-1). | 2008 | 18593294 |
| effect of hiv-1 and antiretroviral therapy on herpes simplex virus type 2: a prospective study in african women. | to document the natural history of herpes simplex virus type 2 (hsv-2) in relation to hiv and highly active antiretroviral therapy (haart) in africa, a longitudinal study was conducted of women in the placebo arms of two randomised controlled trials of hsv-suppressive therapy in burkina faso. | 2008 | 18596069 |
| neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1. | herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) belong to the family herpesviridae, the subfamily alphaherpesvirinae, and the genus simplexvirus. they are ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. herpes simplex encephalitis (hse) is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequelae, which afflict patients for life. hsv-1 has been suggested ... | 2008 | 18599953 |
| herpes simplex encephalitis as an initial presentation of creutzfeldt-jakob disease. | 2008 | 18605370 | |
| viral sexually transmitted infections and bacterial vaginosis: 2001-2004 national health and nutrition examination survey data. | bacterial vaginosis (bv) is a common condition believed to be associated with sexually transmitted infection (sti) susceptibility. most studies of bv and stis have come from treatment-seeking or high-risk populations. this study examines the association between 5 viral stis, human papilloma virus (hpv), hiv, herpes simplex viruses types 1 and 2 (hsv-1 and hsv-2), and hepatitis c (hcv), and bv among women in the general us population. | 2008 | 18607314 |
| do protective behaviors follow the experience of testing positive for herpes simplex type 2? | to test the hypothesis that individuals attending a sexually transmitted disease (std) clinic would adopt sexual protective behaviors after receiving a positive test for herpes simplex virus 2 (hsv-2). | 2008 | 18607318 |
| successful kinase bypass with new acyclovir phosphoramidate prodrugs. | novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (hsv) types 1 and 2 and varicella-zoster virus (vzv). unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the acv-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase. | 2008 | 18614365 |
| high diagnostic yield by csf-pcr for entero- and herpes simplex viruses and tbev serology in adults with acute aseptic meningitis in stockholm. | acute aseptic meningitis (aam) affects 10-20/100,000 inhabitants per years in sweden. up to the beginning of the 1980s the diagnoses were made by virus isolation and/or determination of viral antibodies in serum. the development of pcr for detection of viruses in csf samples has increased the sensitivity and diagnostic efficiency considerably. we investigated the aetiology of aam and the diagnostic efficiency in an adult population in stockholm, using a limited first-line combination of microbio ... | 2008 | 18615360 |
| an immunomodulating dipeptide, scv-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (hsv-2). | herpes simplex virus type 2 (hsv-2) infections produce a recurrent disease state associated with susceptibility to other pathogens, including human immunodeficiency virus (hiv), and cannot be cured by current therapeutic treatments. the hsv-2 epidemic must therefore be addressed by therapeutic strategies that reduce recurrent lesions and ideally lack the possibility for development of drug resistance. to this end, the therapeutic potential of scv-07 (gamma-d-glutamyl-l-tryptophan), a synthetic d ... | 2008 | 18619817 |