Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| oviposition ecology and species composition of aedes spp. and aedes aegypti dynamics in variously urbanized settings in arbovirus foci in southeastern côte d'ivoire. | aedes mosquito-transmitted outbreaks of dengue and yellow fever have been reported from rural and urban parts of côte d'ivoire. the present study aimed at assessing aedes spp. oviposition ecology in variously urbanized settings within arbovirus foci in southeastern côte d'ivoire. | 2016 | 27682270 |
| vector competence of french polynesian aedes aegypti and aedes polynesiensis for zika virus. | in 2013-2014, french polynesia experienced for the first time a zika outbreak. two aedes mosquitoes may have contributed to zika virus (zikv) transmission in french polynesia: the worldwide distributed ae. aegypti and the polynesian islands-endemic ae. polynesiensis mosquito. | 2016 | 27654962 |
| assessment of local mosquito species incriminates aedes aegypti as the potential vector of zika virus in australia. | within the last 10 years zika virus (zikv) has caused unprecedented epidemics of human disease in the nations and territories of the western pacific and south america, and continues to escalate in both endemic and non-endemic regions. we evaluated the vector competence of australian mosquitoes for zikv to assess their potential role in virus transmission. | 2016 | 27643685 |
| insights into zika virus history, human health effects, and control measures. | 2016 | 27679523 | |
| predicting dengue fever outbreaks in french guiana using climate indicators. | dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. in french guiana, climate-based models are not available to assist in developing an early warning system. this study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue f ... | 2016 | 27128312 |
| spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. | 2016 | 27115737 | |
| external quality assessment of dengue and chikungunya diagnostics in the asia pacific region, 2015. | to conduct an external quality assessment (eqa) of dengue and chikungunya diagnostics among national-level public health laboratories in the asia pacific region following the first round of eqa for dengue diagnostics in 2013. | 2016 | 27508088 |
| the mitotic spindle: linking teratogenic effects of zika virus with human genetics? | recently, an association between zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption. | 2016 | 27099632 |
| characterization of lethal zika virus infection in ag129 mice. | mosquito-borne zika virus (zikv) typically causes a mild and self-limiting illness known as zika fever, which often is accompanied by maculopapular rash, headache, and myalgia. during the current outbreak in south america, zikv infection during pregnancy has been hypothesized to cause microcephaly and other diseases. the detection of zikv in fetal brain tissue supports this hypothesis. because human infections with zikv historically have remained sporadic and, until recently, have been limited t ... | 2016 | 27093158 |
| microcephaly and zika virus: neonatal neuroradiological aspects. | the aim of this study is to describe some radiological features in the newborns with microcephaly caused by zika virus infection during pregnancy. | 2016 | 27080092 |
| clinical features and neuroimaging (ct and mri) findings in presumed zika virus related congenital infection and microcephaly: retrospective case series study. | to report radiological findings observed in computed tomography (ct) and magnetic resonance imaging (mri) scans of the first cases of congenital infection and microcephaly presumably associated with the zika virus in the current brazilian epidemic. | 2016 | 27075009 |
| the zika pandemic - a perfect storm? | 2016 | 26991663 | |
| zika: structuring the european research response. | studies are needed to assess #zika virus risks and to develop diagnostic tests http://ow.ly/zaozw. | 2016 | 27730165 |
| on the seasonal occurrence and abundance of the zika virus vector mosquito aedes aegypti in the contiguous united states. | an ongoing zika virus pandemic in latin america and the caribbean has raised concerns that travel-related introduction of zika virus could initiate local transmission in the united states (u.s.) by its primary vector, the mosquito aedes aegypti. | 2016 | 27066299 |
| zika virus outbreak: 'a perfect storm'. | 2016 | 26956448 | |
| differential susceptibilities of aedes aegypti and aedes albopictus from the americas to zika virus. | since the major outbreak in 2007 in the yap island, zika virus (zikv) causing dengue-like syndromes has affected multiple islands of the south pacific region. in may 2015, the virus was detected in brazil and then spread through south and central america. in december 2015, zikv was detected in french guiana and martinique. the aim of the study was to evaluate the vector competence of the mosquito spp. aedes aegypti and aedes albopictus from the caribbean (martinique, guadeloupe), north america ( ... | 2016 | 26938868 |
| the expanding spectrum of modes of transmission of zika virus: a global concern. | 2016 | 26939897 | |
| highly divergent dengue virus type 1 genotype sets a new distance record. | dengue viruses (denvs) are the leading cause of mosquito-borne viral disease of humans. they exist in both endemic and sylvatic ecotypes. in 2014, a viremic patient who had recently visited the rainforests of brunei returned to australia displaying symptoms consistent with denv infection. a unique denv strain was subsequently isolated from the patient, which we propose belongs to a new genotype within denv serotype 1 (denv-1). bayesian evolutionary phylogenetic analysis suggests that the putativ ... | 2016 | 26924208 |
| zika virus infection: new threat in global health. | 2016 | 26955231 | |
| larvicidal potential of the halogenated sesquiterpene (+)-obtusol, isolated from the alga laurencia dendroidea j. agardh (ceramiales: rhodomelaceae), against the dengue vector mosquito aedes aegypti (linnaeus) (diptera: culicidae). | dengue is considered a serious public health problem in many tropical regions of the world including brazil. at the moment, there is no viable alternative to reduce dengue infections other than controlling the insect vector, aedes aegypti linnaeus. in the continuing search for new sources of chemicals targeted at vector control, natural products are a promising alternative to synthetic pesticides. in our work, we investigated the toxicity of a bioactive compound extracted from the red alga laure ... | 2016 | 26821032 |
| anticipating the international spread of zika virus from brazil. | 2016 | 26777915 | |
| the genetic basis of host preference and resting behavior in the major african malaria vector, anopheles arabiensis. | malaria transmission is dependent on the propensity of anopheles mosquitoes to bite humans (anthropophily) instead of other dead end hosts. recent increases in the usage of long lasting insecticide treated nets (llins) in africa have been associated with reductions in highly anthropophilic and endophilic vectors such as anopheles gambiae s.s., leaving species with a broader host range, such as anopheles arabiensis, as the most prominent remaining source of transmission in many settings. an. arab ... | 2016 | 27631375 |
| bacterial larvicide, bacillus thuringiensis israelensis strain am 65-52 water dispersible granule formulation impacts both dengue vector, aedes aegypti (l.) population density and disease transmission in cambodia. | a multi-phased study was conducted in cambodia from 2005-2011 to measure the impact of larviciding with the bacterial larvicide, bacillus thuringiensis israelensis (bti), a water dispersible granule (wg) formulation on the vector, aedes aegypti (l.) and the epidemiology. in our studies, all in-use containers were treated at 8 g/1000 l, including smaller containers and animal feeders which were found to contribute 23% of ae aegypti pupae. the treated waters were subjected to routine water exchang ... | 2016 | 27627758 |
| zika: an old virus with a new face. | zika virus is a mosquito-borne flavivirus that represents a public health emergency at the ongoing epidemic. this obscure virus was limited to sporadic cases in africa and asia, until the emergence of zika virus in brazil in 2015, when it rapidly spread throughout the americas. most zika virus infections are subclinical or characterized by mild febrile illness. however, neurological complications, including guillain-barré syndrome in adults, and congenital anomalies, including microcephaly in ba ... | 2016 | 27703544 |
| isolation of zika virus imported from tonga into australia. | the globally emergent zika virus (zikv) is a threat to australia, given the number of imported cases from epidemic regions and the presence of competent mosquito vectors. we report the isolation of zikv from a female traveler who recently returned from tonga to brisbane, queensland, australia in 2016. | 2016 | 27679739 |
| use of transgenic aedes aegypti in brazil: risk perception and assessment. | the ox513a strain of aedes aegypti, which was developed by the british company oxitec, expresses a self-limiting transgene that prevents larvae from developing to adulthood. in april 2014, the brazilian national technical commission on biosafety completed a risk assessment of ox513a and concluded that the strain did not present new biological risks to humans or the environment and could be released in brazil. at that point, brazil became the first country to approve the unconstrained release of ... | 2016 | 27843167 |
| an ecological assessment of the pandemic threat of zika virus. | the current outbreak of zika virus poses a severe threat to human health. while the range of the virus has been cataloged growing slowly over the last 50 years, the recent explosive expansion in the americas indicates that the full potential distribution of zika remains uncertain. moreover, many studies rely on its similarity to dengue fever, a phylogenetically closely related disease of unknown ecological comparability. here we compile a comprehensive spatially-explicit occurrence dataset from ... | 2016 | 27564232 |
| complete genome sequences of three historically important, spatiotemporally distinct, and genetically divergent strains of zika virus: mr-766, p6-740, and prvabc-59. | here, we report the 10,807-nucleotide-long consensus rna genome sequences of three spatiotemporally distinct and genetically divergent zika virus strains, with the functionality of their genomic sequences substantiated by reverse genetics: mr-766 (african lineage, uganda, 1947), p6-740 (asian lineage, malaysia, 1966), and prvabc-59 (asian lineage-derived american strain, puerto rico, 2015). | 2016 | 27540058 |
| zika virus: a call to action for physicians in the era of climate change. | in february 2016, the world health organization declared the mosquito-borne zika virus to be a "public health emergency of international concern" as the disease linked to thousands of birth defects in brazil spreads rapidly. the distribution of the aedes mosquitos has drastically increased over the past few decades, which have been the hottest decades on earth in more than 1000 years based on climate proxy measures. although a combination of factors explains the current zika virus outbreak, it's ... | 2016 | 27617189 |
| the importance of male body size on sperm uptake and usage, and female fecundity in aedes aegypti and aedes albopictus. | adult mosquito density is a critical factor in the transmission of arboviruses by container aedes spp. mosquitoes. female fecundity drives population growth, and therefore contributes to adult mosquito density. previous studies have focused on female body size as the major determinant of fecundity, paying little attention to male condition. in this study, we examined the effects of male body size on the abundance of sperm in spermatheca, depletion of sperm over time, and female fecundity. | 2016 | 27519588 |
| the critical role of early dengue surveillance and limitations of clinical reporting - implications for non-endemic countries. | the increasing dengue burden and epidemic severity worldwide have highlighted the need to improve surveillance. in non-endemic areas such as taiwan, where outbreaks start mostly with imported cases from southeast asia, a closer examination of surveillance dynamics to detect cases early is necessary. to evaluate problems with dengue surveillance and investigate the involvement of different factors at various epidemic stages, we investigated 632 laboratory-confirmed indigenous dengue cases in kaoh ... | 2016 | 27501302 |
| genetically modified (gm) mosquito use to reduce mosquito-transmitted disease in the us: a community opinion survey. | mosquito-borne infectious diseases such as dengue, chikungunya, and now zika, pose a public health threat to the us, particularly florida, the gulf coast states, and hawaii. recent autochthonous transmission of dengue and chikungunya in florida, the recent dengue outbreak in hawaii, and the potential for future local spread of zika in the us, has led to the consideration of novel approaches to mosquito management. one such novel approach, the release of sterile genetically modified mosquitoes, h ... | 2016 | 27366585 |
| a sequence of flushing and drying of breeding habitats of aedes aegypti (l.) prior to the low dengue season in singapore. | in dengue-endemic areas, transmission shows both a seasonal and interannual variability. to investigate how rainfall impacts dengue seasonality in singapore, we carried out a longitudinal survey in the geylang neighborhood from august 2014 to august 2015. the survey comprised of twice-weekly random inspections to outdoor breeding habitats and continuous monitoring for positive ones. in addition, observations of rainstorms were collected. out of 6824 inspected habitats, 67 contained aedes aegypti ... | 2016 | 27459322 |
| a review of chikungunya virus-induced arthralgia: clinical manifestations, therapeutics, and pathogenesis. | chikungunya virus (chikv) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. additionally, the current literature reports that chikv can result in a severe chronic arthralgia and/or arthri ... | 2016 | 28077980 |
| analysis of chikungunya virus proteins reveals that non-structural proteins nsp2 and nsp3 exhibit rna interference (rnai) suppressor activity. | rnai pathway is an antiviral defence mechanism employed by insects that result in degradation of viral rna thereby curbing infection. several viruses including flaviviruses encode viral suppressors of rnai (vsrs) to counteract the antiviral rnai pathway. till date, no vsr has been reported in alphaviruses. the present study was undertaken to evaluate chikungunya virus (chikv) proteins for rnai suppressor activity. we systematically analyzed all nine chikv proteins for rnai suppressor activity us ... | 2016 | 27901124 |
| diet-induced nutritional stress and pathogen interference in wolbachia-infected aedes aegypti. | the pathogen interference phenotype greatly restricts infection with dengue virus (denv) and other pathogens in wolbachia-infected aedes aegypti, and is a vital component of wolbachia-based mosquito control. critically, the phenotype's causal mechanism is complex and poorly understood, with recent evidence suggesting that the cause may be species specific. to better understand this important phenotype, we investigated the role of diet-induced nutritional stress on interference against denv and t ... | 2016 | 27893736 |
| cross-mating compatibility and competitiveness among aedes albopictus strains from distinct geographic origins - implications for future application of sit programs in the south west indian ocean islands. | the production of large numbers of males needed for a sustainable sterile insect technique (sit) control program requires significant developmental and operational costs. this may constitute a significant economic barrier to the installation of large scale rearing facilities in countries that are undergoing a transition from being largely dependent on insecticide use to be in a position to integrate the sit against aedes albopictus. alternative options available for those countries could be to r ... | 2016 | 27806056 |
| recent chikungunya virus infection in 2 travelers returning from mogadishu, somalia, to italy, 2016. | 2016 | 27513985 | |
| chikungunya virus infection: an update on joint manifestations and management. | the advent of sophisticated diagnostics has enabled the discovery of previously unknown arthropod-borne viruses like chikungunya. this infection has become increasingly prevalent in the last 10 years across the indian ocean and has been brought to media attention by a recent outbreak in the caribbean. the outbreak has been aided by a drastic rise in air travel, allowing infected individuals to transport the virus to previously unaffected regions. in addition, a recently documented viral mutation ... | 2016 | 27824550 |
| in silico study on anti-chikungunya virus activity of hesperetin. | the re-emerging, aedes spp. transmitted chikungunya virus (chikv) has recently caused large outbreaks in a wide geographical distribution of the world including countries in europe and america. though fatalities associated with this self-remitting disease were rarely reported, quality of patients' lives have been severely diminished by polyarthralgia recurrence. neither effective antiviral treatment nor vaccines are available for chikv. our previous in vitro screening showed that hesperetin, a b ... | 2016 | 27812412 |
| use of household cluster investigations to identify factors associated with chikungunya virus infection and frequency of case reporting in puerto rico. | chikungunya virus (chikv) is transmitted by aedes species mosquitoes and is the cause of an acute febrile illness characterized by potentially debilitating arthralgia. after emerging in the caribbean in late 2013, the first locally-acquired case reported to public health authorities in puerto rico occurred in may 2014. during june-august 2014, household-based cluster investigations were conducted to identify factors associated with infection, development of disease, and case reporting. | 2016 | 27764085 |
| chikungunya virus transmission between aedes albopictus and laboratory mice. | chikungunya virus (chikv) is a mosquito-borne alphavirus associated with epidemics of acute and chronic arthritic disease in humans. aedes albopictus has emerged as an important new natural vector for chikv transmission; however, mouse models for studying transmission have not been developed. | 2016 | 27760560 |
| mapping of courses on vector biology and vector-borne diseases systems: time for a worldwide effort. | major emergency efforts are being mounted for each vector-borne disease epidemiological crisis anew, while knowledge about the biology of arthropods vectors is dwindling slowly but continuously, as is the number of field entomologists. the discrepancy between the rates of production of knowledge and its use and need for solving crises is widening, in particular due to the highly differing time spans of the two concurrent processes. a worldwide web based search using multiple key words and search ... | 2016 | 27759770 |
| chikungunya virus in febrile humans and aedes aegypti mosquitoes, yucatan, mexico. | chikungunya virus (chikv) was isolated from 12 febrile humans in yucatan, mexico, in 2015. one patient was co-infected with dengue virus type 1. two additional chikv isolates were obtained from aedes aegypti mosquitoes collected in the homes of patients. phylogenetic analysis showed that the chikv isolates belong to the asian lineage. | 2016 | 27347760 |
| climate change influences potential distribution of infected aedes aegypti co-occurrence with dengue epidemics risk areas in tanzania. | dengue is the second most important vector-borne disease of humans globally after malaria. incidence of dengue infections has dramatically increased recently, potentially due to changing climate. climate projections models predict increases in average annual temperature, precipitation and extreme events in the future. the objective of this study was to assess the effect of changing climate on distribution of dengue vectors in relation to epidemic risk areas in tanzania. | 2016 | 27681327 |
| culex quinquefasciatus from rio de janeiro is not competent to transmit the local zika virus. | the americas have suffered a dramatic epidemic of zika since may in 2015, when zika virus (zikv) was first detected in brazil. mosquitoes belonging to subgenus stegomyia of aedes, particularly aedes aegypti, are considered the primary vectors of zikv. however, the rapid spread of the virus across the continent raised several concerns about the transmission dynamics, especially about potential mosquito vectors. the purpose of this work was to assess the vector competence of the house mosquito cul ... | 2016 | 27598421 |
| knowledge and use of prevention measures for chikungunya virus among visitors - virgin islands national park, 2015. | in june 2014, the mosquito-borne chikungunya virus (chikv) emerged in the u.s. virgin islands (usvi), a location where tourists comprise the majority of the population during peak season (january-april). limited information is available concerning visitors' chikv awareness and prevention measures. | 2016 | 27597388 |
| genetic evidence of expansion by passive transport of aedes (stegomyia) aegypti in eastern argentina. | 2016 | 27583521 | |
| zika virus, a new threat for europe? | since its emergence in 2007 in micronesia and polynesia, the arthropod-borne flavivirus zika virus (zikv) has spread in the americas and the caribbean, following first detection in brazil in may 2015. the risk of zikv emergence in europe increases as imported cases are repeatedly reported. together with chikungunya virus (chikv) and dengue virus (denv), zikv is transmitted by aedes mosquitoes. any countries where these mosquitoes are present could be potential sites for future zikv outbreak. we ... | 2016 | 27505002 |
| expression and characterization of yeast derived chikungunya virus like particles (chik-vlps) and its evaluation as a potential vaccine candidate. | chikungunya virus (chikv) has emerged as a global health concern due to its recent spread in both old and new world. so far, no chikv specific drug or vaccine is licensed for human use. in this study, we report production of chikungunya virus like particles (chik-vlps) using novel yeast expression system (pichia pastoris) and its evaluation as vaccine candidate. the gene encoding structural polyprotein of chikv from a recent epidemic strain was cloned into yeast expression system. the multicopy ... | 2016 | 27399001 |
| vector competence of aedes aegypti in transmitting chikungunya virus: effects and implications of extrinsic incubation temperature on dissemination and infection rates. | aedes aegypti is a competent arthropod vector of chikungunya virus (chikv). the rate at which the virus disseminate in the vector is limited by temperature of their environment which can be an important determinant of geographical and seasonal limits to transmission by the arthropods in the tropics. this study investigated the vector competence of ae. aegypti for chikv at ambient temperature of 32 and 26 °c (coastal and western kenya respectively) reared at extrinsic incubation temperature (eit) ... | 2016 | 27357190 |
| development of neutralization assay using an egfp chikungunya virus. | chikungunya virus (chikv), a member of the alphavirus genus, is an important human emerging/re-emerging pathogen. currently, there are no effective antiviral drugs or vaccines against chikv infection. herein, we construct an infectious clone of chikv and an egfp reporter chikv (egfp-chikv) with an isolated strain (assigned to asian lineage) from chikv-infected patients. the egfp-chikv reporter virus allows for direct visualization of viral replication through the levels of egfp expression. using ... | 2016 | 27367716 |
| isolation of infective zika virus from urine and saliva of patients in brazil. | zika virus (zikv) is an emergent threat provoking a worldwide explosive outbreak. since january 2015, 41 countries reported autochthonous cases. in brazil, an increase in guillain-barré syndrome and microcephaly cases was linked to zikv infections. a recent report describing low experimental transmission efficiency of its main putative vector, ae. aegypti, in conjunction with apparent sexual transmission notifications, prompted the investigation of other potential sources of viral dissemination. ... | 2016 | 27341420 |
| seroprevalence of anti-chikungunya virus antibodies in children and adults in managua, nicaragua, after the first chikungunya epidemic, 2014-2015. | chikungunya is a viral disease transmitted by aedes aegypti and ae. albopictus mosquitoes. in late 2013, chikungunya virus (chikv) was introduced into the caribbean island of st. martin. since then, approximately 2 million chikungunya cases have been reported by the pan american health organization, and most countries in the americas report autochthonous transmission of chikv. in nicaragua, the first imported case was described in july 2014 and the first autochthonous case in september 2014. her ... | 2016 | 27322692 |
| antiviral hammerhead ribozymes are effective for developing transgenic suppression of chikungunya virus in aedes aegypti mosquitoes. | the chikungunya virus (chikv) is an emerging pathogen with widespread distribution in regions of africa, india, and asia that threatens to spread into temperate climates with the introduction of its major vector, aedes albopictus. chikv causes a disease frequently misdiagnosed as dengue fever, with potentially life-threatening symptoms that can result in a longer-term debilitating arthritis. the increasing risk of spread from endemic regions via human travel and commerce and the current absence ... | 2016 | 27294950 |
| dengue vaccine: considerations before rollout in colombia. | 2016 | 27280803 | |
| novel lesions of bones and joints associated with chikungunya virus infection in two mouse models of disease: new insights into disease pathogenesis. | chikungunya virus is an arbovirus spread predominantly by aedes aegypti and ae. albopictus mosquitoes, and causes debilitating arthralgia and arthritis. while these are common manifestations during acute infection and it has been suggested they can recur in patients chronically, gaps in knowledge regarding the pathogenesis still exist. two established mouse models were utilized (adult irf 3/7 -/- -/- and wild-type c57bl/6j mice) to evaluate disease manifestations in bones and joints at various t ... | 2016 | 27182740 |
| identification and characterization of two novel rna viruses from anopheles gambiae species complex mosquitoes. | mosquitoes of the anopheles gambiae complex display strong preference for human bloodmeals and are major malaria vectors in africa. however, their interaction with viruses or role in arbovirus transmission during epidemics has been little examined, with the exception of o'nyong-nyong virus, closely related to chikungunya virus. deep-sequencing has revealed different rna viruses in natural insect viromes, but none have been previously described in the anopheles gambiae species complex. here, we d ... | 2016 | 27138938 |
| leukemoid reaction in chikungunya fever. | chikungunya is a viral illness caused by an arbovirus which is transmitted by aedes mosquito. fever and polyarthralgia are hallmark of this viral illness. viral infections are generally associated with leucopenia and bacterial infections with leukocytosis. leukemoid reaction (lr) is defined by reactive increase in leukocyte count of more than 50,000/cu mm with increase in mature leukocytes on peripheral blood. leukocytosis is common in chikungunya but leukemoid reaction has not been reported in ... | 2016 | 27437276 |
| prevalence of dengue and chikungunya virus infections in north-eastern tanzania: a cross sectional study among participants presenting with malaria-like symptoms. | in spite of increasing reports of dengue and chikungunya activity in tanzania, limited research has been done to document the general epidemiology of dengue and chikungunya in the country. this study aimed at determining the sero-prevalence and prevalence of acute infections of dengue and chikungunya virus among participants presenting with malaria-like symptoms (fever, headache, rash, vomit, and joint pain) in three communities with distinct ecologies of north-eastern tanzania. | 2016 | 27112553 |
| molecular characterisation of clinical isolates of chikungunya virus: a study from tertiary care hospitals in southern india. | indian ocean islands and india have experienced massive severe chikungunya outbreak from 2005 up till now and then chikungunya became epidemic in india. the mutations that occurred in e1 gene were responsible for increased infectivity, virulence and host adaptability. it is important to find out the genotype and its probable evolvement and novel mutations in the e1 gene reported during 2006-2009 from the current isolates, which may affect the local protein structure. | 2016 | 27134872 |
| forecasting chikungunya spread in the americas via data-driven empirical approaches. | chikungunya virus (chikv) is endemic to africa and asia, but the asian genotype invaded the americas in 2013. the fast increase of human infections in the american epidemic emphasized the urgency of developing detailed predictions of case numbers and the potential geographic spread of this disease. | 2016 | 26928307 |
| first imported case of chikungunya virus infection in a travelling canadian returning from the caribbean. | this is the first canadian case of chikungunya virus (chikv) infection reported in a traveller returning from the caribbean. following multiple mosquito bites in martinique island in january 2014, the patient presented with high fever, headaches, arthralgia on both hands and feet, and a rash on the trunk upon his return to canada. initial serological testing for dengue virus infection was negative. support therapy with nonsteroidal anti-inflammatory drugs was administered. the symptoms gradually ... | 2016 | 27366163 |
| aedes mosquitoes and zika virus infection: an a to z of emergence? | 2016 | 26905027 | |
| assessing chikungunya risk in a metropolitan area of argentina through satellite images and mathematical models. | chikungunya fever is a viral disease that recently invaded the american continent. in america, it is transmitted mainly by the mosquito aedes aegypti, but aedes albopictus is the main vector in other regions of the world. this work estimates the risk of disease emergence and the corresponding population at risk for the case of a naive population in the metropolitan area of buenos aires, the capital city of argentina. | 2016 | 26830024 |
| whole-genome sequencing analysis from the chikungunya virus caribbean outbreak reveals novel evolutionary genomic elements. | chikungunya virus (chikv), an alphavirus and member of the togaviridae family, is capable of causing severe febrile disease in humans. in december of 2013 the asian lineage of chikv spread from the old world to the americas, spreading rapidly throughout the new world. given this new emergence in naïve populations we studied the viral genetic diversity present in infected individuals to understand how chikv may have evolved during this continuing outbreak. | 2016 | 26807575 |
| chikungunya: epidemiology. | chikungunya virus is a mosquito-borne alphavirus that causes fever and debilitating joint pains in humans. joint pains may last months or years. it is vectored primarily by the tropical and sub-tropical mosquito, aedes aegypti, but is also found to be transmitted by aedes albopictus, a mosquito species that can also be found in more temperate climates. in recent years, the virus has risen from relative obscurity to become a global public health menace affecting millions of persons throughout the ... | 2016 | 26918158 |
| genetic characterization of spondweni and zika viruses and susceptibility of geographically distinct strains of aedes aegypti, aedes albopictus and culex quinquefasciatus (diptera: culicidae) to spondweni virus. | zika virus (zikv) has extended its known geographic distribution to the new world and is now responsible for severe clinical complications in a subset of patients. while substantial genetic and vector susceptibility data exist for zikv, less is known for the closest related flavivirus, spondweni virus (sponv). both zikv and sponv have been known to circulate in africa since the mid-1900s, but neither has been genetically characterized by gene and compared in parallel. furthermore, the susceptibi ... | 2016 | 27783682 |
| a cost-effectiveness tool for informing policies on zika virus control. | as zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. for example, to combat the current zika outbreak the us president requested the allocation of $1.8 billion from congress in february 2016. | 2016 | 27205899 |
| time to empower release of insects carrying a dominant lethal and wolbachia against zika. | ridl (release of insects with dominant lethality) and wolbachia are 2 potentially powerful tools in the fight against zika, but their technological advancement is being hampered by policy barriers. in this study, we discuss what could be done to overcome these regulatory deadlocks. | 2016 | 27419175 |
| estimated zika virus importations to europe by travellers from brazil. | given the interconnectivity of brazil with the rest of the world, zika virus (zikv) infections have the potential to spread rapidly around the world via viremic travellers. the extent of spread depends on the travel volume and the endemicity in the exporting country. in the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of zikv from brazil into europe. | 2016 | 27193266 |
| personal protection of permethrin-treated clothing against aedes aegypti, the vector of dengue and zika virus, in the laboratory. | the dengue and zika viruses are primarily transmitted by aedes aegypti mosquitoes, which are most active during day light hours and feed both in and outside of the household. personal protection technologies such as insecticide-treated clothing could provide individual protection. here we assessed the efficacy of permethrin-treated clothing on personal protection in the laboratory. | 2016 | 27187593 |
| the persistence and ecological impacts of a cyanobacterium genetically engineered to express mosquitocidal bacillus thuringiensis toxins. | the cyanobacterium anabaena pcc 7120#11 has been genetically engineered to act as a delivery vehicle for bacillus thuringiensis subspecies israelensis mosquitocidal toxins. to address ecological concerns about releasing this genetically engineered microorganism into the environment for mosquito larva control, the persistence and ecological impacts of pcc 7120#11 was evaluated using multi-species, standardized aquatic microcosms. | 2016 | 27165108 |
| the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine is a potent inhibitor of in vitro zika virus replication and delays disease progression in a robust mouse infection model. | zika virus (zikv) is an emerging flavivirus typically causing a dengue-like febrile illness, but neurological complications, such as microcephaly in newborns, have potentially been linked to this viral infection. we established a panel of in vitro assays to allow the identification of zikv inhibitors and demonstrate that the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine (7dma) efficiently inhibits replication. infection of ag129 (ifn-α/β and ifn-γ receptor knock-out) mice with zikv res ... | 2016 | 27163257 |
| zika virus, elevation, and transmission risk. | zika virus has appeared in the americas in the form of a major outbreak, and is now known to cause birth defects when pregnant women are infected. as a result, the centers for disease control and prevention issued travel guidelines, in the form of an elevational risk definition: destinations below 2000m are considered as at-risk. | 2016 | 27280061 |
| wolbachia modulates lipid metabolism in aedes albopictus mosquito cells. | certain strains of the intracellular endosymbiont wolbachia can strongly inhibit or block the transmission of viruses such as dengue virus (denv) by aedes mosquitoes, and the mechanisms responsible are still not well understood. direct infusion and liquid chromatography-fourier transform ion cyclotron resonance (ft-icr) mass spectrometry-based lipidomics analyses were conducted using aedes albopictus aa23 cells that were infected with the wmel and wmelpop strains of wolbachia in comparison to un ... | 2016 | 26994075 |
| high-throughput cis-regulatory element discovery in the vector mosquito aedes aegypti. | despite substantial progress in mosquito genomic and genetic research, few cis-regulatory elements (cres), dna sequences that control gene expression, have been identified in mosquitoes or other non-model insects. formaldehyde-assisted isolation of regulatory elements paired with dna sequencing, faire-seq, is emerging as a powerful new high-throughput tool for global cre discovery. faire results in the preferential recovery of open chromatin dna fragments that are not bound by nucleosomes, an ev ... | 2016 | 27161480 |
| a deep insight into the sialome of male and female aedes aegypti mosquitoes. | only adult female mosquitoes feed on blood, while both genders take sugar meals. accordingly, several compounds associated with blood feeding (i.e. vasodilators, anti-clotting, anti-platelets) are found only in female glands, while enzymes associated with sugar feeding or antimicrobials (such as lysozyme) are found in the glands of both sexes. we performed de novo assembly of reads from adult aedes aegypti female and male salivary gland libraries (285 and 90 million reads, respectively). by mapp ... | 2016 | 26999592 |
| particularities of allergy in the tropics. | allergic diseases are distributed worldwide and their risk factors and triggers vary according to geographical and socioeconomic conditions. allergies are frequent in the tropics but aspects of their prevalence, natural history, risk factors, sensitizers and triggers are not well defined and some are expected to be different from those in temperate zone countries. the aim of this review is to investigate if allergic diseases in the tropics have particularities that deserve special attention for ... | 2016 | 27386040 |
| antinociceptive effect of tephrosia sinapou extract in the acetic acid, phenyl-p-benzoquinone, formalin, and complete freund's adjuvant models of overt pain-like behavior in mice. | tephrosia toxicaria, which is currently known as tephrosia sinapou (buc'hoz) a. chev. (fabaceae), is a source of compounds such as flavonoids. t. sinapou has been used in amazonian countries traditional medicine to alleviate pain and inflammation. the purpose of this study was to evaluate the analgesic effects of t. sinapou ethyl acetate extract in overt pain-like behavior models in mice by using writhing response and flinching/licking tests. we demonstrated in this study that t. sinapou extract ... | 2016 | 27293981 |
| proceedings of the 3rd ipleiria's international health congress : leiria, portugal. 6-7 may 2016. | 2016 | 27409075 | |
| the influence of urbanization modes on the spatial circulation of flaviviruses within ouagadougou (burkina faso). | dengue is an emerging infectious disease of global significance. although this virus has been reported for a long time, its significance within the burden of diseases in west africa is not obvious, especially in burkina faso. our objective was to evaluate flavivirus presence in ouagadougou (burkina faso) and the link between anti-flavivirus antibody seroprevalence and urbanization modes. a population-based cross-sectional survey was conducted and 3015 children were enrolled from ouagadougou dist ... | 2016 | 27973402 |
| detection of human anti-zika virus igg by elisa using an antigen from in vitro infected vero cells: preliminary results. | zika virus (zkv) infection is a huge public health problem in brazil because of the increased incidence of microcephaly in neonates from infected mothers. detection of specific igg antibodies in maternal serum samples constitutes an important approach for diagnosing zkv infection and evaluating its relationship with neonatal microcephaly. however, as there is no serological test produced in brazil to detect igm and igg antibodies against zkv, we sought to examine specific igg in serum samples fr ... | 2016 | 27982355 |
| invasive mutualisms between a plant pathogen and insect vectors in the middle east and brazil. | complex multi-trophic interactions in vectorborne diseases limit our understanding and ability to predict outbreaks. arthropod-vectored pathogens are especially problematic, with the potential for novel interspecific interactions during invasions. variations and novelties in plant-arthropod-pathogen triumvirates present significant threats to global food security. we examined aspects of a phytoplasma pathogen of citrus across two continents. 'candidatus phytoplasma aurantifolia' causes witches' ... | 2016 | 28083099 |
| comparative analysis of dengue and zika outbreaks reveals differences by setting and virus. | the pacific islands of micronesia have experienced several outbreaks of mosquito-borne diseases over the past decade. in outbreaks on small islands, the susceptible population is usually well defined, and there is no co-circulation of pathogens. because of this, analysing such outbreaks can be useful for understanding the transmission dynamics of the pathogens involved, and particularly so for yet understudied pathogens such as zika virus. here, we compared three outbreaks of dengue and zika vir ... | 2016 | 27926933 |
| aedes (stegomyia) albopictus' dynamics influenced by spatiotemporal characteristics in a brazilian dengue-endemic risk city. | brazil reported the majority of the dengue cases in americas during the last two decades, where the occurrence of human dengue cases is exclusively attributed to the aedes (stegomyia) aegypti (linnaeus). nowadays, other recognized dengue virus (denv) vector in asian countries, aedes (stegomyia) albopictus (skuse), has been detected in more than half of the 5565 brazilian municipalities. therefore, the aim of the present study was to investigate the presence of, and determine the ae. albopictus' ... | 2016 | 27771419 |
| analysis of synonymous codon usage bias of zika virus and its adaption to the hosts. | zika virus (zikv) is a mosquito-borne virus (arbovirus) in the family flaviviridae, and the symptoms caused by zikv infection in humans include rash, fever, arthralgia, myalgia, asthenia and conjunctivitis. codon usage bias analysis can reveal much about the molecular evolution and host adaption of zikv. to gain insight into the evolutionary characteristics of zikv, we performed a comprehensive analysis on the codon usage pattern in 46 zikv strains by calculating the effective number of codons ( ... | 2016 | 27893824 |
| a prospective cohort study to assess seroprevalence, incidence, knowledge, attitudes and practices, willingness to pay for vaccine and related risk factors in dengue in a high incidence setting. | dengue is one of the most important vector-borne diseases in the world, causing significant morbidity and economic impact. in colombia, dengue is a major public health problem. departments of la guajira, cesar and magdalena are dengue endemic areas. the objective of this research is to determine the seroprevalence and the incidence of dengue virus infection in the participating municipalities from these departments, and also establish the association between individual and housing factors and ve ... | 2016 | 27887591 |
| tsetse fly tolerance to t. brucei infection: transcriptome analysis of trypanosome-associated changes in the tsetse fly salivary gland. | for their transmission, african trypanosomes rely on their blood feeding insect vector, the tsetse fly (glossina sp.). the ingested trypanosoma brucei parasites have to overcome a series of barriers in the tsetse fly alimentary tract to finally develop into the infective metacyclic forms in the salivary glands that are transmitted to a mammalian host by the tsetse bite. the parasite population in the salivary gland is dense with a significant number of trypanosomes tightly attached to the epithe ... | 2016 | 27884110 |
| susceptibility profile and metabolic mechanisms involved in aedes aegypti and aedes albopictus resistant to ddt and deltamethrin in the central african republic. | aedes aegypti and ae. albopictus are the main epidemic vectors of dengue, chikungunya and zika viruses worldwide. their control during epidemics relies mainly on control of larvae and adults with insecticides. unfortunately, loss of susceptibility of both species to several insecticide classes limits the efficacy of interventions. in africa, where aedes-borne viruses are of growing concern, few data are available on resistance to insecticides. to fill this gap, we assessed the susceptibility to ... | 2016 | 27881148 |
| generation of monoclonal antibodies against native viral proteins using antigen-expressing mammalian cells for mouse immunization. | due to their rising incidence and progressive geographical spread, infections with mosquito-borne viruses, such as dengue (denv), chikungunya and zika virus, have developed into major public health challenges. since all of these viruses may cause similar symptoms and can occur in concurrent epidemics, tools for their differential diagnosis and epidemiological monitoring are of urgent need. | 2016 | 27876044 |
| the driving force for 2014 dengue outbreak in guangdong, china. | dengue fever has rapidly spread in recent decades to become the most globally expansive viral vector-borne disease. in mainland china, a number of dengue outbreaks have been reported since 1978, but the worst epidemic in decades, involving 45230 cases and 76 imported cases, resulting in six deaths in guangdong province, emerged in 2014. reasons for this ongoing surge in dengue, both imported and autochthonous, are currently unclear and demand urgent investigation. here, a seasonally-driven dynam ... | 2016 | 27861514 |
| genomic studies of envelope gene sequences from mosquito and human samples from bangkok, thailand. | dengue virus (denv) is an rna virus showing a high degree of genetic variation as a consequence of its proofreading inability. this variation plays an important role in virus evolution and pathogenesis. although levels of within-host genetic variation are similar following equilibrium, variation among different hosts is frequently different. to identify dengue quasispecies present among two hosts, we collected patient samples from six acute denv cases and two pools of aedes aegypti mosquitoes an ... | 2016 | 27917342 |
| detection of dengue virus serotypes 1, 2 and 3 in selected regions of kenya: 2011-2014. | dengue fever, a mosquito-borne disease, is associated with illness of varying severity in countries in the tropics and sub tropics. dengue cases continue to be detected more frequently and its geographic range continues to expand. we report the largest documented laboratory confirmed circulation of dengue virus in parts of kenya since 1982. | 2016 | 27814732 |
| comprehensive dna methylation analysis of the aedes aegypti genome. | aedes aegypti mosquitoes are important vectors of viral diseases. mosquito host factors play key roles in virus control and it has been suggested that dengue virus replication is regulated by dnmt2-mediated dna methylation. however, recent studies have shown that dnmt2 is a trna methyltransferase and that dnmt2-dependent methylomes lack defined dna methylation patterns, thus necessitating a systematic re-evaluation of the mosquito genome methylation status. we have now searched the ae. aegypti g ... | 2016 | 27805064 |
| dengue outbreak in mombasa city, kenya, 2013-2014: entomologic investigations. | dengue outbreaks were first reported in east africa in the late 1970s to early 1980s including the 1982 outbreak on the kenyan coast. in 2011, dengue outbreaks occurred in mandera in northern kenya and subsequently in mombasa city along the kenyan coast in 2013-2014. following laboratory confirmation of dengue fever cases, an entomologic investigation was conducted to establish the mosquito species, and densities, causing the outbreak. affected parts of the city were identified with the help of ... | 2016 | 27783626 |
| the interplay of vaccination and vector control on small dengue networks. | dengue fever is a major public health issue affecting billions of people in over 100 countries across the globe. this challenge is growing as the invasive mosquito vectors, aedes aegypti and aedes albopictus, expand their distributions and increase their population sizes. hence there is an increasing need to devise effective control methods that can contain dengue outbreaks. here we construct an epidemiological model for virus transmission between vectors and hosts on a network of host populatio ... | 2016 | 27457093 |
| zika mosquito vectors: the jury is still out. | after a 40-year hiatus, the international congress of entomology (ice 2016) convened in orlando, florida (september 25-30, 2016). one of the symposia at ice 2016, the zika symposium, covered multiple aspects of the zika epidemic, including epidemiology, sexual transmission, genetic tools for reducing transmission, and particularly vector competence. while there was a consensus among participants that the yellow fever mosquito, aedes aegypti, is a vector of the zika virus, there is growing eviden ... | 2016 | 27853521 |
| polyphenol-rich diets exacerbate ampk-mediated autophagy, decreasing proliferation of mosquito midgut microbiota, and extending vector lifespan. | mosquitoes feed on plant-derived fluids such as nectar and sap and are exposed to bioactive molecules found in this dietary source. however, the role of such molecules on mosquito vectorial capacity is unknown. weather has been recognized as a major determinant of the spread of dengue, and plants under abiotic stress increase their production of polyphenols. | 2016 | 27732590 |
| emergence of epidemic dengue-1 virus in the southern province of sri lanka. | dengue is a frequent cause of acute febrile illness with an expanding global distribution. since the 1960s, dengue in sri lanka has been documented primarily along the heavily urbanized western coast with periodic shifting of serotypes. outbreaks from 2005-2008 were attributed to a new clade of denv-3 and more recently to a newly introduced genotype of denv-1. in 2007, we conducted etiologic surveillance of acute febrile illness in the southern province and confirmed dengue in only 6.3% of febri ... | 2016 | 27711206 |