Publications

inhibition of 5'-deiodination of thyroxine suppresses the cold-induced increase in brown adipose tissue messenger ribonucleic acid for mitochondrial uncoupling protein without influencing lipoprotein lipase activity.	young adult male and female djungarian hamsters were exposed to ambient temperatures of 23 or 0 c for 12 h; half of the animals in each group were treated with iopanoic acid to suppress the peripheral conversion of t4 to the thermotropically active thyroid hormone t3 by the enzyme 5'-deiodinase (5'd). brown adipose tissue (bat) mrna for uncoupling protein (ucp), bat lipoprotein lipase (lpl) activity, and 5'd activity were measured at the conclusion of the study. a temperature of 0 c produced lar ...	1990	2328697
regulation of iodothyronine 5'-deiodinases: effects of thiol blockers and altered substrate levels in vivo and in vitro.	to study the physiological regulation of the iodothyronine 5'-deiodinases (i-5'd), we have examined the effects of some thiol blockers and of thyroid status on i-5'd activities both in vitro and in vivo. at low (less than 5 mm) concentrations of dithiothreitol, propylthiouracil (ptu) inhibited i-5'd in the brain, pituitary, and brown adipose tissue (bat) of hypothyroid rats (which contain predominantly the type ii activity); the patterns of inhibition in these tissues were essentially similar, w ...	1990	2328700
calcium is the first messenger for the action of thyroid hormone at the level of the plasma membrane: first evidence for an acute effect of thyroid hormone on calcium uptake in the heart.	the thyroid hormone t3 produced a very rapid and transient increase in 45calcium uptake by freshly isolated rat heart slices, which was seen already 15 sec after the addition of the hormone, reached a maximum at 30 sec, and then progressively declined and returned to control values after 10 min. this effect of t3 was independent of extracellular calcium, concentration related (evident at a physiological concentration of 10 pm, reached maximum of about 75% above control at 1 nm, and was smaller a ...	1990	2328703
contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term.	normal dams were equilibrated isotopically with [125i]t4 infused from 11 to 21 days of gestation, at which time maternal and fetal extrathyroidal tissues were obtained to determine their [125i]t4 and t4 contents. the specific activity of the [125i]t4 in the fetal tissues was lower than in maternal t4 pools. the extent of this change allows evaluation of the net contribution of maternal t4 to the fetal extrathyroidal t4 pools. at 21 days of gestation, near term, this represents 17.5 +/- 0.9% of t ...	1990	2328706
thyroid hormone transport in a human glioma cell line.	the uptake of 3,5,3'-triiodothyronine (t3) and thyroxine (t4) was studied in human glioma cells (hs 683) and compared with that in several other neural cell lines. at 25 degrees c or 37 degrees c, total cell uptake rose rapidly and reached equilibrium within 60 min. the glioma cells had the highest uptake: 47.6 fmol of l-t3 and 43.4 fmol of l-t4 per 10(6) cells at 37 degrees c. these were inhibited 77% and 72%, respectively, by excess unlabeled hormone. uptake in the nuclei reached equilibrium b ...	1990	2328825
[the functional links in the neuroendocrine interrelationship in juvenile uterine hemorrhages].	a simultaneous and combined study of function of the neuroendocrine regulation of menstrual function in patients with juvenile uterine bleeding (jub) (by the excretion of lh, noradrenalin, dopa and dopamine with urine and by the blood levels of tsh, t3, t4, acth and cortisol and by functional diagnostic tests) has shown that jub is characterized by dysfunction of all important factors in this complex neuro-regulatory chain, resulting in disorder of hormonal homeostasis and pathological changes i ...	1990	2330360
[complications of the postoperative use of lumbar epidural catheters in place for surgery].	two cases of secondary subarachnoidal dislocation of lumbar epidural catheters are reported. the first catheter was placed, tested, and injected with 20 ml local anesthetic in order to achieve intraoperative anesthesia up to the t4 level. on the 2nd postoperative day the test dose produced paralysis of the lower extremities; liquor now could be aspirated. the second catheter had been introduced into the epidural space immediately after injection of 15 ml local anesthetic through the needle. use ...	1990	2330430
[the effect of diet therapy on the hormonal spectrum of patients with bronchial asthma].	results are reported of an investigation of the levels of cortisol, pancreatic and thyroid hormones in 38 patients with the infectious-allergic form of bronchial asthma. unloading dietotherapy was accompanied by an improvement of the clinical course of the disease, reduction of necessity in broncholytic and hormonal agents. during the unloading dietotherapy period some variants of hormonal response to hunger were revealed. patients with a severe course of the acidotic crisis revealed a reduction ...	1990	2330711
the acute effects of food and glucose challenge on plasma thyroxine and triiodothyronine levels in previously starved rainbow trout (oncorhynchus mykiss).	the acute effects of a single meal on plasma l-thyroxine (t4) and 3,5,3'-triiodo-l-thyronine (t3) levels were examined in rainbow trout starved for 3 days. plasma t4 increased within 2 hr of food intake and remained elevated to 8 hr. plasma t3 was not altered consistently. feeding-induced elevations in plasma t4 were present only in trout weighing less than 250 g and if they consumed a ration exceeding 0.38% of body weight. postprandial elevations in plasma glucose paralleled those in plasma t4, ...	1990	2332149
il-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the bb rat.	long term effects of in vivo treatment with human ril-1 beta on diabetogenesis and thyroid disease were determined in the biobreeding rat. administration of high dose (10 micrograms/kg) il-1 beta accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. high dose treatment resulted in goiter development, pronounced lt, reduced serum t4 levels, and overall growth reduction. in contrast, low dose il-1 beta (0.5 microgram/kg) administration significantly red ...	1990	2332631
small colloidal gold conjugated to fab fragments or to immunoglobulin g as high-resolution labels for electron microscopy: a technical overview.	fab-colloidal gold labelling in conjunction with negative staining and high-resolution electron microscopy was used for targeting single protein units in regular arrays. these were bacteriophage t4 polyheads with fab-au2.5, and a specific antibody binding site on the haemagglutinin polypeptide of influenza virus with fab-au3, fab-au2.5, and fab-au1-2. for the latter, igg-au3 was also used. experimental details are summarized to provide generally applicable methods for the preparation of small go ...	1990	2332806
vertical transmission of human immunodeficiency virus is correlated with the absence of high-affinity/avidity maternal antibodies to the gp120 principal neutralizing domain.	many, but not all, infants born to mothers infected with the human immunodeficiency virus (hiv) are infected in utero. we have now shown that mothers who have high-affinity/avidity antibodies directed toward the principal neutralizing domain (pnd) of gp120 are less likely to transmit hiv to their children. an elisa that preferentially measures the level of the biologically functioning, high-affinity/avidity antibodies against pnd is described. in a retrospective study of 15 maternal/neonatal ser ...	1990	2333294
thyroidal and peripheral production of 3,5,3'-triiodothyronine in humans by multicompartmental analysis.	multicompartmental analysis of thyroxine (t4) and 3,5,3'-triiodothyronine (t3) kinetics based on the plasma disappearance curves of the two tracer hormones (j. j. distefano iii, m. jang, t. k. malone, and m. broutman. endocrinology 110: 198-213, 1982 and j. j. distefano iii, t. k. malone, and m. jang. endocrinology 111: 108-117, 1982) was extended to include additional experimental data, namely, the appearance curve in plasma of labeled t3 generated in vivo from precursor t4. kinetic analysis of ...	1990	2333963
is crystalloid preloading useful in spinal anaesthesia in the elderly?	sixty asa grade 1 or 2 patients, aged 60 years or over, scheduled for surgery to the lower abdomen or lower limbs under spinal anaesthesia were allocated randomly to one of three treatment groups. group a received 16 ml/kg of ringer's acetate solution immediately before spinal anaesthesia, group b received 8 ml/kg and group c received no volume preload. heart rate, arterial pressure and anaesthetic level were recorded by an independent observer. the overall incidence of systemic arterial hypoten ...	1990	2334037
evaluation of the sensitivity of microfilter paper assays in an anthropological study: results of samples from cameroon and tanzania.	microfilter absorbed whole blood samples from 223 tanzanian babies and 189 adults from cameroon have been examined. blood specimens are difficult to obtain from african suburban and rural areas, and lack of storage and transportation facilities can prevent the collection of samples. we evaluated some microassays employing whole blood collected on filter paper. this method is a well established technique in neonatal screening for endocrinometabolic diseases. we also developed microassays for whol ...	1990	2334145
structure of a thermostable disulfide-bridge mutant of phage t4 lysozyme shows that an engineered cross-link in a flexible region does not increase the rigidity of the folded protein.	a disulfide bond introduced between amino acid positions 9 and 164 in phage t4 lysozyme has been shown to significantly increase the stability of the enzyme toward thermal denaturation [matsumura, m., becktel, w.j., levitt, m., & matthews, b. w. (1989) proc. natl. acad. sci. u.s.a. 86, 6562-6566]. to elucidate the structural features of the engineered disulfide, the crystal structure of the disulfide mutant has been determined at 1.8-a resolution. residue 9 lies in the n-terminal alpha-helix, wh ...	1990	2334683
effect of an engineered disulfide bond on the folding of t4 lysozyme at low temperatures.	equilibrium and kinetic effects on the folding of t4 lysozyme were investigated by fluorescence emission spectroscopy in cryosolvent. to study the role of disulfide cross-links in stability and folding, a comparison was made with a mutant containing an engineered disulfide bond between cys-3 (ile-3 in the wild type) and cys-97, which links the c-terminal domain to the n terminus of the protein [perry & wetzel (1984) science 226, 555]. in our experimental system, stability toward thermal and dena ...	1990	2334694
detection of 1,n6-propanodeoxyadenosine in acrolein-modified polydeoxyadenylic acid and dna by 32p postlabeling.	the interaction of acrolein, an alpha,beta-unsaturated aldehyde, with polydeoxyadenylic acid and dna has been investigated using 32p-postlabeling analysis. in preliminary experiments, polydeoxyadenylic acid was incubated with excess acrolein and then digested to 3' monophosphates prior to transfer of 32p from [gamma-32p]atp with t4 polynucleotide kinase. the 3',5'-bisphosphates were 3'-dephosphorylated prior to two-dimensional thin layer chromatography on polyethyleneimine-cellulose layers. auto ...	1990	2334905
effect of gossypol on thyroid hormones in young female rats.	the study was designed to examine the effect of gossypol on thyroid function in young female rats. forty young sprague-dawley female rats were randomly assigned to four treatment groups. the dosages of gossypol acetic acid (gossypol) used for this experiment were 1, 5 and 10 mg/kg body weight/day in 0.5 ml potassium phosphate buffer subcutaneously started from day 34 of age for 15 consecutive days. the control group was treated with vehicle alone. animals were sacrificed 15 days after gossypol t ...	1990	2335106
changes in thyroid status in newborn infants utero-exposed to ritodrine.	a clinical study to assess whether utero exposure to ritodrine influences thyroid status was performed in 21 healthy term newborn infants, 10 exposed in utero to ritodrine (treated group) and 11 non-exposed in utero to drugs (control group). the treated group had a t3/t4 ratio significantly higher than the control group (mean +/- sd: 124.10 +/- 23.70 vs. 96.09 +/- 18.11, p less than 0.005) and t3 slightly increased (mean +/- sd nmol/l 2.48 +/- 0.69 vs. 1.95 +/- 0.56). the mean serum values of th ...	1990	2335252
does a hidden pool of reverse triiodothyronine (rt3) production contribute to total thyroxine (t4) disposal in high t4 states in man.	a hidden pool of rt3 production represents a source of rt3 that is minimally reflected in circulating rt3 levels. to test for the existence of such a source of rt3 production in man, varying doses of the generalized deiodinase inhibitor iopanoic acid (ia) were administered to four hyperthyroxinemic subjects. the doses employed included low-ia (0.5-g load, then 0.5 g/day for 5 days), mid-ia (1.0-g load, then 1.0 g/day for 5 days), and high-ia (3.0-g load, then 3.0 g/day for 5 days). each patient ...	1990	2335581
serum thyrotropin in hospitalized psychiatric patients: evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotropin assay.	in order to gather further insight into the basis for high serum t4 and/or t3 of psychiatric illnesses, we studied thyroid function in 84 consecutive newly hospitalized psychiatric patients (hpp) in a 12-week period. serum t4 and t3 were measured by immunoassay and thyrotropin (thyroid-stimulating hormone [tsh]) by an ultrasensitive immunoradiometric assay. serum t4 was in the normal range in 64 (76%) and elevated in 20 (24%); free t4 index was elevated in 13 of 75 (16%), total t3 in 12 of 60 (2 ...	1990	2336036
ph-induced denaturation of proteins: a single salt bridge contributes 3-5 kcal/mol to the free energy of folding of t4 lysozyme.	the energetics of a salt bridge formed between the side chains of aspartic acid 70 (asp70) and histidine 31 (his31) of t4 lysozyme have been examined by nuclear magnetic resonance techniques. the pka values of the residues in the native state are perturbed from their values in the unfolded protein such that his31 has a pka value of 9.1 in the native state and 6.8 in the unfolded state at 10 degrees c in moderate salt. similarly, the aspartate pka is shifted to a value of about 0.5 in the native ...	1990	2337607
[subtotal thyroid gland resection as therapy for thyrotoxic crises].	thyrotoxic crises occurred in six patients (four women aged 51, 63, 72 and 76 years; two men aged 52 and 63 years). in four patients the crisis was triggered by a contrast medium containing iodine, and in one by amiodarone. the cause of the crisis in the 51-year-old woman remained uncertain. after a latent period of up to two months, t3 and t4 concentrations rose in all the patients, and abnormal findings such as tachycardia, increased blood pressure, dehydration, tremor, restlessness, hallucina ...	1990	2338059
presence of thyroxine 5'-monodeiodinase activity in kidney homogenates of the frog, rana ridibunda.	conversion of thyroxine (t4) to triiodothyronine (t3), which was demonstrated in the 6000-g supernatant fraction of kidney homogenates prepared from rana ridibunda frogs, was influenced by substrate (0.19-1.5 microm) and homogenate (39-625 mg kidney/ml) concentration and by temperature (19.5-36.5 degrees) and duration (1 hr vs 2 hr) of incubation. heating destroyed 5'-monodeiodinase activity. addition of dithiothreitol (dtt) to the reaction mixture appeared to be essential to quantitate t3 produ ...	1990	2338224
serum concentrations of thyroid hormones and activity of iodothyronine deiodinase in peripheral tissues of the house musk shrew, suncus murinus.	serum concentrations of thyroid hormones and the properties of iodothyronine deiodinase in tissues of the house musk shrew, suncus murinus, were examined and compared with those of the rat. serum concentrations of thyroxine (t4) and 3,3',5'-tri-iodothyronine (rt3) were higher, while the serum concentration of 3,5,3'-tri-iodothyronine (t3) was lower in the shrew than in the rat. among liver, kidney, skeletal muscle, heart, brown adipose tissue (bat), spleen, lung, testes and thymus homogenates of ...	1990	2338528
prostaglandins in squamous cell carcinoma of the larynx: tumor and peritumor synthesis.	prostaglandin (pg) e2, 6ketopgf1 alpha and thromboxane b2 (txb2) production by the tumor, peritumor and control tissue were investigated in specimens from patients (n = 11) with squamous cell carcinoma of the larynx, in relation to the extension and infiltration of the neoplasm and to the presence of inflammation, fibrosis and necrosis. in all specimens detectable amounts of 6ketopgf1+ and txb2 were found, but the predominant metabolite was pge2. no differences in the levels of txb2 and 6ketopgf ...	1990	2339137
[cancer of the lips. results of the treatment of 299 patients].	from 1970 to 1985, 299 patients with carcinoma of the lip were entirely managed at the bergonié foundation. interstitial radiotherapy was most commonly used. it resulted in a successful local control in 96% of cases (238/248), while cosmetic and functional results seemed better than those of surgery. however, surgery seemed more performant for in situ carcinomas, late aggressive t3 carcinomas, local recurrences, as for t4 lesions associated with other techniques. after reviewing the case history ...	1990	2339862
tissue-specific regulation of the expression of rat kallikrein gene family members by thyroid hormone.	we have altered the thyroid hormonal status of both male and female rats and examined the expression of six functional members of the rat kallikrein gene family (ps, s1, s2, s3, k1 and p1) in the submandibular gland (smg), kidney, prostate, testis and anterior pituitary gland (ap) of these animals. on northern-blot analysis with gene-specific oligonucleotide probes, the steady-state mrna levels of s1, s2, s3, k1 and p1 were all dramatically altered in the smg of male and female rats treated with ...	1990	2339984
analysis of t lymphocyte subsets in all stages of diabetes.	direct immunofluorescence analysis of circulating blood lymphocytes from patients with all stages of type i diabetes revealed marked phenotypic abnormalities among all major t-lymphocyte subpopulations. the alterations were most pronounced in the prediabetics and comprised a stimulation of the t4+2h4+ and t8+2h4+ suppressor inducer subpopulations and corresponding depression of the t4+4b4+ helper inducers.	1990	2340061
neuromedin u-like immunoreactivity in the thyroid gland of the rat.	neuromedin u is a novel neuropeptide found to have a widespread distribution extending throughout the mammalian central nervous system, gastrointestinal tract and the endocrine cells of the pituitary gland. in order to investigate the possibility that neuromedin u-like immunoreactivity is also present in the thyroid gland of the adult rat we have examined its localisation and molecular nature by radioimmunoassay, immunocytochemistry and chromatographic analysis. the neuromedin u content of the w ...	1990	2340578
spect gallium-67 scanning in early human immunodeficiency virus (hiv) infection. failure of scanning abnormalities to correlate with immunologic staging.	the use of gallium scanning in the treatment of patients with aids has been well described. in this study, 27 hiv-infected patients (walter reed staging classification i-v) with normal chest roentgenograms were evaluated to determine the occurrence of thoracic gallium abnormalities in early hiv infection. spect was used for gallium scanning. patients received gallium injection on day 1 and bronchoalveolar lavage on day 2, and scanning was performed on day 3. twenty-eight scans in 27 patients wer ...	1990	2340670
[correlation of diameters measured by x-ray computed tomography and intraparietal extension of squamous cell carcinoma of the thoracic esophagus. apropos of 101 anatomoradiologic comparisons].	in order to assess the value of tomodensitometric classification of squamous cell carcinomas of the upper esophagus, which has been recently advocated, we compared the ct-measured diameters and the extent of intraparietal invasion in 101 tumors. according to selected criteria (superficial -t1- tumors: not apparent or less than 10 mm; tumors infiltrating incompletely the muscularis -t2- ; mass less than 10 to less than 20 mm in diameter; tumors extending beyond the muscularis -t3, t4- : diameter ...	1990	2341503
an rna holliday junction? structural and dynamic considerations of the bacteriophage t4 gene 60 interruption.	a novel interrupted gene motif has been reported in which a 50-nucleotide insertion into bacteriophage t4 gene 60 appears to be present in the message at the time of translation, yet it is not translated. we present here a dynamic model for how translation may be occurring in the neighborhood of the interruption. the model involves formation of an rna structure with similarities to a holliday junction, followed by migration of the branch point in a strand exchange between message and interruptio ...	1990	2342100
pituitary regulation of the male-specific steroid 6 beta-hydroxylase p-450 2a (gene product iiia2) in adult rat liver. suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;.	oligonucleotide probes that distinguish between two closely related mrnas encoding steroid 6 beta-hydroxylases of rat p-450 gene family cyp3a were used to individually assess their responsiveness to pituitary hormone regulation. northern blot analysis revealed that the elevation of immunoreactive p-450 iiia2 in livers of hypophysectomized rats reflects an elevation of the constitutive, male-specific p-450 iiia2 (p-450 2a) and not an induction of the drug-inducible p-450 iiia1 (p-450p). p-450 iii ...	1990	2342479
[the lymphocyte populations at different stages in the infection caused by the human immunodeficiency virus].	in 58 persons infected with hiv the comparative study of the content of immunocompetent cells was carried out by the methods of rosette formation and immunofluorescence with the use of monoclonal antibodies. an increase in the content of rosette-forming cells (rfc), such as active e-rfc, e-rfc, theophylline-resistant e-rfc and m-frc, in asymptomatic seropositive persons was established. at this stage of the disease the amount of lymphocytes t4 and t8 and their ratio underwent no essential change ...	1990	2343681
the effect of 0.5% ropivacaine on epidural blood flow.	twenty patients scheduled for elective abdominal surgery received epidural analgesia with 20 ml 0.5% ropivacaine or 0.5% bupivacaine. epidural blood flow was measured by an epidural 133xe clearance technique on the day before surgery (no local anaesthetic) and again 1 h before surgery, 30 min after injection of the local anaesthetic during continuous infusion (8 ml/h). median initial blood flow was 5.0 ml/min and 6.0 ml/min per 100 g tissue in patients receiving ropivacaine and bupivacaine, resp ...	1990	2343734
[prospective study of hiv infection in a group of 30 young hemophiliacs].	in order to investigate the progression to aids, we studied 39 patients with hemophilia ranging presently in age from 8 to 20 years, who had been positive for hiv antibodies for a mean of 36 months. every 3 to 6 months a clinical and laboratory examination was performed. the number of patients with aids increased from 2 to 6 and 2 patients died from opportunistic infections. the percentage of patients with less than 500 t4 cells increased from 28% to 41%. increase in serum iga concentrations abo ...	1990	2344245
the effect of d- versus l-propranolol in the treatment of hyperthyroidism.	the purpose of this study is to determine whether there is a difference in treatment of hyperthyroidism using either the d- or l-isomer of propranolol. two groups of 20 patients with overt hyperthyroidism received either 120 mg l- or d-propranolol each for a period of 5 days. in the d-propranolol administered group there was a significant decrease in tt3 and ft3 plasma levels and in the ratio of tt3 to tt4; however, a significant increase occurred in rt3 values up to day 5. on the other hand, l- ...	1990	2344697
[products of expression of cloned phage t4 basal plate genes 29, 28, 27, 51 and 26].	we used bacterial strains with two recombinant plasmids carrying bglii dna fragment with t4 genes 25-29 in different orientations. in the case of the plasmid prl705 phage dna fragment had correct orientation for transcription of t4 late genes, and in the plasmid prl707 it has the opposite one. transcription from the pl promoter of the plasmid prl705 led to the synthesis of 4 proteins which according to the molecular weights observed were the products of t4 genes 29, 28, 27, and 51. in the case o ...	1990	2344958
heat mutagenesis in bacteriophage t4: another walk down the transversion pathway.	extracellular nonreplicating bacteriophage t4 particles accumulate mutations as functions of temperature, time, ph, and ionic environment via two mechanisms: 5-hydroxymethylcytidine deamination produces g.c----a.t transitions while a guanosine modification produces transversions. neither frameshift mutations nor mutations at a.t base pairs are appreciably induced. we now show that heat induces g.c----t.a transversions which we suggest may arise via a g.a mispair, in which g is a modified guano ...	1990	2345133
leakage of thyroid hormone-inducible monoamine oxidase inhibitor from rat liver cytosol.	t4-induced endogenous monoamine oxidase (mao) inhibitor in rat liver perfusate by perfusion with sucrose buffer and lipid peroxide (lpo) and superoxide dismutase (sod) in rat liver tissues were investigated after pretreatment with total hepatic ischemia. when the gel filtration of these rats liver perfusate were carried out using sephadex g-25, fraction 18-20 were found to inhibit mao activity. lpo of these rats were increased, but sod activity was decreased. the accumulation of lipid peroxides ...	1990	2345806
the many faces of sarcoidosis. the thomé villar memorial lecture.	sarcoidosis wears many different faces, depending upon the viewer, who may be clinician, radiologist, pathologist or immunologist. this thomé villar memorial lecture salutes the charismatic chest physician who pioneered studies of the disorder in lisbon and transmitted this knowledge internationally. the four main themes of this lisbon conference are granuloma formation, granulomatous vasculitis, markers of activity and occupational granulomatous lung diseases; these four faces of sarcoidosis ar ...	1990	2345814
comparison of atrophic and goitrous auto-immune thyroiditis in children: clinical, laboratory and tsh-receptor antibody studies.	we studied the clinical features, laboratory and thyroid functions and thyrotropin (tsh)-receptor and thyroid-stimulation antibodies in 21 patients with atrophic auto-immune thyroiditis (aat) and 48 patients with goitrous auto-immune thyroiditis (gat) of childhood onset. the clinical features of patient with aat were cessation of growth and obesity, while asymptomatic enlargement of the thyroid gland was the sole symptom in most patients with gat. although the ages at diagnosis were comparable i ...	1990	2347350
the effect of extrathyroidal conversion inhibitor from food-deprived animals on iodothyronines deiodination by pituitary and cerebral cortical homogenates in vitro.	the influence of an inhibitor of iodothyronines' extrathyroidal conversion on t4, t3 and rt3 deiodination by adult pig pituitary and cerebral cortical homogenates has been investigated. the homogenates were incubated with t4, t3 and rt3 in the presence of 5 mm dithiothreitol and evaporated diethyl ether extracts of sera obtained from fed and starved (1-14 days) rabbits. the extracts had no influence either on t4 to t3 or on t4 to rt3 conversion in cerebral cortex. deiodination of rt3 to 3,3'-t2 ...	1990	2347541
role of epidural analgesia on endocrine & metabolic responses to surgery.	serum levels of cortisol, t3, t4 and blood levels of glucose, lactate and pyruvate were measured 15 min before anaesthesia, 15 and 60 min after skin incision and at 2 h after surgery, in 16 patients undergoing elective surgery on lower extremities either under epidural analgesia (group i) or general anaesthesia (group ii). the results showed that as long as the effect of epidural analgesia persisted, it could inhibit the increases in cortisol and blood glucose and the decreases in t3 levels, obs ...	1990	2347606
pulsatile secretion of thyrotropin during fasting: a decrease of thyrotropin pulse amplitude.	the effect of fasting on circadian and pulsatile tsh secretion was investigated in eight healthy subjects (four men and four women in the follicular phase). each subject was studied twice, once during 24 h with normal food intake and once during the last 24 h of a 60-h fast. blood was sampled every 10 min during 24 h for measurement of tsh by a sensitive immunoradiometric assay. fasting induced a decrease in plasma t3 [1.73 +/- 0.06 vs. 1.36 +/- 0.04 nmol/l; p less than 0.01 (mean +/- se), contr ...	1990	2347898
amiodarone does not affect the distribution and fractional turnover of triiodothyronine from the plasma pool, but only its generation from thyroxine in extrathyroidal tissues.	the peripheral metabolism of t3 has been studied in 10 hypothyroid patients receiving daily oral replacement doses of 200 micrograms t4 or 60 micrograms t3, in divided doses, before and during treatment with 400 mg amiodarone (amd) daily for 3 weeks. each patient received 1 microci/kg bw [125i]t3, iv. blood samples were drawn at 10, 20, 30, and 60 min and 2, 4, 6, 8, 12, 24, 36, 48, 60, and 72 h, followed by trichloroacetic acid precipitation and ethanol extraction of the serum samples. the para ...	1990	2347903
decreased sensitivity to alpha-adrenergic stimulation in hypothyroid patients.	nine hypothyroid patients had blood pressure and pulse rate responses to the alpha-adrenergic agonist phenylephrine measured before [t4 index, 45.045 +/- 9.009 nmol/l (mean +/- sem); tsh, 57.1 +/- 23.6 mu/l] and after 4 +/- 0.5 months of thyroid replacement therapy (t4 index, 141.570 +/- 29.601 nmol/l; tsh, 2.6 +/- 1.0 mu/l). hypothyroid patients had a smaller blood pressure increment and heart rate decrement at both 66.7 and 100 micrograms/min infusion rates of phenylephrine. furthermore, the s ...	1990	2347907
compliance and laboratory data predict relapse rate of pneumocystis carinii pneumonia during prophylaxis with aerosol pentamidine.	we evaluated 43 aids patients on prophylaxis with aerosol pentamidine (60 mg biweekly) after pneumocystis carinii pneumonia (pcp). the effects of patients' inhalation compliance and of laboratory data during the initial pcp on subsequent pcp relapses were assessed. after a median of 8 months (range, 2-21.5 months) on pentamidine prophylaxis, 13 patients suffered a pcp relapse. six of them had missed at least one inhalation within the last month before the relapse. two of these six relapses were ...	1990	2348643
bacteriophage t4 gene 27.		1990	2349100
double-blind crossover trial of diltiazem versus propranolol in the management of thyrotoxic symptoms.	we compared the efficacy of diltiazem and propranolol in a randomized, prospective, double-blind, crossover study in six patients with untreated thyrotoxicosis (mean age 31 yrs). the patients received either diltiazem 60 mg orally four times a day or propranolol 40 mg orally four times a day, each for 1 week, separated by a 3-day drug-free period. blood pressure, heart rate, thyroid hormone levels (free t4, t3), electrocardiogram, two-dimensional and m-mode echocardiograms, and doppler studies w ...	1990	2349134
homologous pairing in vitro initiated by dna synthesis.	a number of models have been proposed for the initiation of general genetic recombination. one of these, originally proposed by meselson and radding, imagines that the single-stranded 5' tail that results from strand displacement dna repair synthesis can initiate homologous recombination by invading a homologous duplex. the resultant d-loop intermediate is then processed into mature products. we demonstrate here that an in vitro system composed of the bacteriophage t4 uvsx protein (a reca-like " ...	1990	2350351
prognosis in laryngeal carcinoma: host factors.	a personal series of 1171 patients with a laryngeal tumour seen in a 27-year period from 1962 to 1988 is reported. of these patients, 763 were previously untreated and had a histologically proved squamous cell carcinoma. the interaction between the host factors (age, sex and general condition) and other tumour factors, and the effect of the host factors on survival were analysed. the maximum age incidence was the same in the two sexes but performance status (general condition) declined with incr ...	1990	2350886
flavonoid administration immediately displaces thyroxine (t4) from serum transthyretin, increases serum free t4, and decreases serum thyrotropin in the rat.	naturally occurring and synthetic plant flavonoids, such as emd 21388, are potent inhibitors of thyroid hormone 5'-deiodinase (5'-d) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (ttr). emd 21388 also inhibits the binding of t4 to human, dog, and rat serum ttr in vitro and when administered to rats in vivo. in the present studies the administration of emd 21388 inhibited the binding of t4 to ttr within 3 min, resulting in a decrease in the serum t4 con ...	1990	2351100
iodothyronine deiodinase activities in frtl5 cells: predominance of type i 5'-deiodinase.	frtl5 cells, a thyroid follicular cell line derived from normal rat thyroid, has been extensively used as a model system to study various aspects of the physiology of the thyroid epithelium. the capacity of these cells to metabolize iodothyronines and to generate t3 from t4 has not been previously examined. here we studied the deiodination of t4, t3, and rt3 in homogenates of frtl5 cells. by far, these homogenates were more potent catalyzing the 5'-deiodination (outer ring) of t4 and rt3 than th ...	1990	2351108
the transport of thyroxine into mouse neuroblastoma cells, nb41a3: the effect of l-system amino acids.	thyroid hormones must cross the plasma membrane to interact with nuclear or other intracellular receptors. in brain cells, most of the t3 in the nucleus is derived intracellularly from t4. while a saturable transport system has been demonstrated for t3 in a number of cell types, the evidence for such a system for t4 is less well established. in a mouse neuroblastoma cell line (nb41a3) the transport of t4 was found to be stereospecific, saturable, and energy dependent. when cells were incubated w ...	1990	2351115
[the alternation of cd4+ cells and its subpopulations by serial monitoring of peripheral blood lymphocytes of renal allograft recipients].	immunologic monitoring for renal allograft recipients should be carried out serially and as conveniently as possible so that we can catch and treat the initial alternation of the rejection and infection. we have introduced the serial analysis of lymphocyte surface antigens of peripheral blood lymphocytes by flow cytometry for 9 cases of renal allograft recipients (3 cases of living related, 2 cases of living non-related, and 4 cases cadaver donors). in three recipients without rejection and infe ...	1990	2351361
immunomodulatory role of thyroid hormones: in vitro effect of tetraiodothyronine (t4) on mitogen induced blastogenic response of lymphocytes.	an attempt was made to find out the immunomodulatory role of thyroid hormone, tetraiodothyronine (t4), and its effect on in vitro mitogen induced blastogenesis. human peripheral blood lymphocytes (pbl) were subjected to phytohaemagglutinin (pha) concanavalin-a (con. a) and pokeweed mitogen (pwm) in presence or absence of t4. basal blastogenic response was significantly enhanced in dose related manner by t4. pha and con.a induced response was depressed significantly (r = -0.975 and r = -0.945) wh ...	1990	2351415
antimicrobial susceptibility testing of less commonly isolated haemophilus species using haemophilus test medium.	haemophilus test medium (htm) was developed recently for dilution and disk diffusion antimicrobial agent susceptibility testing of haemophilus influenzae. the application of htm to the testing of other, less frequently encountered haemophilus species recovered from humans was evaluated in this study by using commercially prepared htm (bbl microbiology systems, cockeysville, md.) in broth microdilution and agar disk diffusion susceptibility tests with 18 antimicrobial agents. a total of 93.3% of ...	1990	2351742
[voice rehabilitation following total laryngectomy: microvascular laryngeal replacement-plasty (laryngoplasty) instead of voice prosthesis].	since the introduction of the so-called voice prostheses tracheoesophageal puncture is currently the most widely used surgical procedure for vocal rehabilitation after total laryngectomy. the voice prosthesis renders possible a reliably reproducible voice, which is superior (period of uninterrupted sound production, basal frequency, voice intensity) to the other techniques (esophageal speech, external vibrators, other surgical reconstructive measures), but has the following disadvantages: high i ...	1990	2354015
influence of obesity on the spread of spinal analgesia after injection of plain 0.5% bupivacaine at the l3-4 or l4-5 interspace.	spinal anaesthesia was compared in 40 obese patients (increased body mass index (bmi] and 40 patients with normal bmi when 3 ml of plain 0.5% bupivacaine was injected at either the l3-4 or l4-5 interspace. more extensive cephalad spread of sensory block was achieved in patients with increased bmi compared with patients with normal bmi after injection at both l3-4 and l4-5 (p less than 0.05). the use of the l3-4 interspace instead of l4-5 resulted in a higher mean spread of block in patients with ...	1990	2354091
survey of iodine deficiency in a rural area near tehran: association of food intake and endemic goitre.	goitre is endemic in many parts of iran. this study was undertaken first to obtain the base line data and identify the nature of the problem and then to take measures to ameliorate it. shahryar, an endemic area near the capital city, was selected as the pilot field. the sample size was 368 families. sixty-six per cent of females and 54 per cent of males were goitrous. a food consumption survey revealed that 38 per cent and 62 per cent of the families had failed to receive at least 80 per cent of ...	1990	2354688
growth hormone stimulates hepatic thyroxine 5'-monodeiodinase activity and 3,5,3'-triiodothyronine levels in rainbow trout (salmo gairdneri).	intraperitoneal injection of rainbow trout (salmo gairdneri) with 0.4 microgram/g of human growth hormone (hgh) increased plasma levels of 3,5,3'-triiodo-l-thyronine (t3) and vmax of the hepatic microsomal 5'-monodeiodinase enzyme (5'd) that converts thyroxine (t4) to t3, with no effect on km or plasma t4 levels. a dose of 0.4 microgram hgh/g increased both plasma t3 and vmax as early as 8 hr postinjection (pi). maximal levels for both parameters occurred at 24 hr pi and significant stimulation ...	1990	2354760
evidence for the role of thyroxine as a hormone in the physiology of a lizard.	in vivo effects of thyroxine (t4) and triiodothyronine (t3) were studied in male lizards. t4 or t3 (0.5 to 2 nmol) was administered per day over 10 days to surgically thyroidectomized male lizards (35 +/- 2.0 g) and the responses were measured in terms of scale shedding, whole body oxygen consumption (oc), and testicular weight. t3 was more effective in stimulating oc as compared to t4. t4 accelerated scale shedding to a greater extent as compared to t3. t4 was more effective than t3 in restorin ...	1990	2354761
influence of ration level and salinity on circulating thyroid hormones in juvenile atlantic salmon (salmo salar).	following acute exposure to seawater (30 ppt), plasma thyroxine (t4) of atlantic salmon (salmo salar) smolts increased 80% in the first 6 hr, declined to initial levels after 24 hr, and remained stable for 18 days thereafter. in nonsmolts, plasma t4 did not rise immediately after exposure to seawater, fell slightly after 2 days, and remained low for 18 days. plasma triiodothyronine (t3) of smolts and nonsmolts was not affected by acute exposure to seawater. to examine the effect of long-term ada ...	1990	2354765
temperature, thyroxine, and induced metamorphosis in tadpoles of a primitive frog, ascaphus truei.	to understand the environmental factors and endocrine mechanisms which regulate the extended period (2 to 4 years) of larval development in ascaphus, the effect of temperature and thyroxine (t4 by immersion) on metamorphic changes of the tail, limb buds, operculum, anal fold, oral disc, and teeth were studied in premetamorphic and prometamorphic tadpoles. (1) control tadpoles did not undergo metamorphic change at any of the temperatures tested. (2) when tadpoles were kept in thyroxine solutions ...	1990	2354776
dna synthesis is unaffected but subsequent cell division is delayed in tadpole hindlimb epidermis when thyroxine is given in the dark.	in rana pipiens tadpoles, thyroxine (t4) injection in the early light promotes faster hindlimb growth and development than injection early in the dark. t4 also stimulates a significant increase in cell proliferation in the basal epidermal cells of the limb. using autoradiography, we studied the timing of the t4-induced rise in the labeling and mitotic indices on 12l:12d cycles with 0.2 micrograms t4 injection early in the light or dark and on a 12l:3d:1l:8d cycle with a light pulse early in the ...	1990	2354782
increasing age impairs the thyroid hormone response to overfeeding.	aging in both man and rodent is associated with increases in body weight and body fat. in young adult rats, mixed calorie overfeeding increases triiodothyronine production and decreases weight gain efficiency compared with chow diets. this study was undertaken to determine whether 4- and 14-month-old adult rats have similar responses in thyroxine (t4) and triiodothyronine (t3) metabolism during mixed calorie overfeeding. four- and 14-month-old male sprague-dawley rats were each separated into tw ...	1990	2356189
structural studies of immunomodulators. part 2: crystal structure and conformation of azimexon (bm 12.531) an immunostimulant and an anti-tumor drug.	azimexon [2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane] is a derivative of 2-cyanaziridine. azimexon is an immunostimulant which shows therapeutic effects in tumor models and experimental infections in mice in vitro, enhances t lymphocyte transformation in vitro and increases phagocytosis of latex particles by mouse peritoneal cells. in cancer patients it increases blood active t rosettes, increases t4/t8 ratio and is used in the treatment of melanomas. the crystal structure analysis of azi ...	1990	2357266
changes in tsh-immunoreactivity in the pars tuberalis and pars distalis of the fetal rat hypophysis following maternal administration of propylthiouracil and thyroxine.	the pars tuberalis (pt) of the adenohypophysis is unique in its close spatial relationship to the neurohemal contact area of the median eminence. the morphology of pt-specific secretory cells does not resemble cell types of the pars distalis (pd); the functional role of these cells within the endocrine system is still unknown. one group of young mature female wistar rats received propylthiouracil (ptu), a second group thyroxine (t4) (10 mg/l each in drinking water) from about 3 weeks prior to th ...	1990	2357726
carcinoma of the supraglottic larynx: a basis for comparing the results of radiotherapy and surgery.	an analysis of 129 patients with 131 squamous cell carcinomas of the supraglottic larynx treated between october 1964 and april 1987 with radiotherapy alone or radiotherapy followed by neck dissection is presented. all patients had a minimum 2-year follow-up. patients were excluded from analysis of disease control at the primary site and/or neck if they died within 2 years of treatment with the site(s) continuously disease-free. local control rates with radiotherapy and ultimate local control ra ...	1990	2358330
purification and characterization of hela endonuclease r. a g-specific mammalian endonuclease.	we previously reported a double-stranded endonuclease from hela cells, endonuclease r (endo r), which specifically cleaves duplex dna at sites rich in g.c base pairs. in this report we describe the purification of endo r to near homogeneity by conventional and affinity chromatography. the molecular mass of the active form of endo r is approximately 115-125 kda. sds-gel electrophoresis reveals a major protein species of 100 kda. the enzyme requires mg2+ as a cofactor and is equally active on clos ...	1990	2358441
altered thyroid hormone metabolism in advanced heart failure.	to determine the prevalence and significance of abnormal thyroid hormone metabolism in congestive heart failure, free thyroxine (t4) index, free triiodothyronine (t3) index, reverse t3 and thyrotropin levels were obtained in 84 hospitalized patients with chronic advanced heart failure. free t4 index was normal in all patients. free t3 index was reduced or reverse t3 elevated, or both, leading to a low free t3 index/reverse t3 ratio in 49 (58%) of the 84 patients. a low free t3 index/reverse t3 r ...	1990	2358611
autogenous translational operator recognized by bacteriophage t4 dna polymerase.	the synthesis of the dna polymerase of bacteriophage t4 is autogenously regulated. this protein (gp43), the product of gene 43, binds to a segment of its mrna that overlaps its ribosome binding site, and thereby blocks translation. we have determined the kd of the gp43-operator interaction to be 1.0 x 10(-9) m. the minimum operator sequence to which gp43 binds consists of 36 nucleotides that include a hairpin (containing a 5 base-pair helix and an 8 nucleotide loop) and a single-stranded segment ...	1990	2359122
long-term survival of patients with paranasal sinus carcinoma.	the survival rate for all patients with a squamous cell carcinoma of the paranasal sinuses (n = 77) diagnosed in 1960-1985 in a population of approximately 1 million inhabitants was analysed without any selection of cases. this population is geographically restricted to the most northern part of sweden. the 5-year survival rates of patients with t3 and t4 carcinomas were 42 and 14%, respectively (corrected survival), and the 10-year survival rates were 40 and 14%, respectively. in patients with ...	1990	2359595
lymphocyte subsets in bronchoalveolar lavage fluid and in circulating blood in epidermoid bronchogenic carcinoma.	alveolar macrophages, lymphocyte and granulocyte percentages, together with okt3+, okt4+, okt8+ lymphocyte subsets and okt4+/okt8+ ratio, were evaluated in bronchoalveolar lavage (bal) fluid and in peripheral venous blood (pvb) of neoplastic and nonneoplastic subjects, in order to assess these aspects of immunity in neoplastic disease and to find out if the modifications in the bronchoalveolar environment are correlated to the ones in the circulation blood. bal was performed in 30 patients under ...	1990	2359893
determination of replacement and suppressive doses of thyroxine.	suppression daily doses of thyroxine (t4) were determined and the daily amounts of t4 required to replace t4 were established in 217 hypothyroid patients. patients with hashimoto's thyroiditis treated daily with 2-3 micrograms/kg lean body mass or 1-2 micrograms/kg body weight t4 had normal serum thyrotrophin (tsh) concentrations, normal response to tsh-releasing hormone (trh) and normal systolic time intervals but doses higher than 3 micrograms/kg lean body mass or 2 micrograms/kg body weight d ...	1990	2361563
chest wall motion of infants during spinal anesthesia.	to test the extent to which diaphragmatic contraction moves the rib cage in awake supine infants during quiet breathing, we studied chest wall motion in seven prematurely born infants before and during spinal anesthesia for inguinal hernia repair. infants were studied at or around term (postconceptional age 43 +/- 8 wk). spinal anesthesia produced a sensory block at the t2-t4 level, with concomitant motor block at a slightly lower level. this resulted in the loss of most intercostal muscle activ ...	1990	2361911
[anesthetic management of coronary artery bypass graft operation in a patient with hypothyroidism].	we experienced the anesthetic management of coronary artery bypass graft operation (3 vessels) in a patient with hypothyroidism. prior to the operation, the substitution therapy for thyroid hormone was performed, but thyroid function could not be normalized. from 30 minutes after starting cardiopulmonary bypass, edema appeared on four limbs. also, edema of intestinal tract and the distended abdomen was observed. by administering t4 preparation intravenously edema diminished within about 2 hours ...	1990	2362344
[gene 26 of bacteriophage t4 basal plate. i. two expression products of the cloned gene].	we have cloned the 1.9 kb ecorv-bglii dna fragment with t4 genes 51, 26, and 25 into the expression plasmid pt7-5 carrying a t7 promoter. the resulting recombinant plasmid, prr5-3, contained t4 genes 26 and 25 in the correct orientation for expression. we expressed these genes using the t7 rna polymerase/promoter system and the synthesis of three polypeptides with the molecular masses of approximately 24, 15, and 8-9 kda was observed. expression of genes from the subcloned dna fragments and from ...	1990	2362588
[changes in the secondary structure bacteriophage t4 envelope protein after its polymerization].	circular dichroism (cd) spectra of the structural protein of the bacteriophage t4 sheath (gp 18) in a monomeric native state, helices, polysheaths and contracted sheaths were measured in the range 184-310 nm. the secondary structure of the protein studied was calculated from the spectra in the range 190-240 nm according to provencher and glöckner. it has been shown that the polymerization is proceeded without change of the alpha-helical content in the secondary structure of gp 18: estimated alph ...	1990	2362596
[clinical results of conventional fractionation radiotherapy for glottic and supraglottic laryngeal cancers--the usefulness of hyperfractionation for these cancers].	ninety patients with glottic and eighteen patients with supraglottic laryngeal cancer (anyn, m0) were treated by conventional fractionation radiotherapy between july, 1963 and august, 1988. tumor control and cause specific survival were evaluated according to tumor location (glottic or supraglottic) and tumor size (t1, t2, t3, or t4). as a result, the steepness of dose-response curve for the tumor control in t1-2 glottic and t2 supraglottic tumors was more slanting upwards than that in other lar ...	1990	2362794
cloning and sequencing of bacteriophage t4 genes between map positions 128.3-130.3.		1990	2362813
effect of d-tubocurarine pretreatment on succinylcholine twitch augmentation and neuromuscular blockade.	subparalyzing doses of d-tubocurarine (dtc) given before succinylcholine decrease the duration of neuromuscular blockade. in animal preparations, they also abolish succinylcholine-induced twitch augmentation, defined as a greater-than-maximal contraction in response to a single stimulus. to determine quantitatively the effect of dtc on succinylcholine potency and on twitch augmentation in humans, 60 adult patients, asa physical status i or ii, were assigned randomly to receive either 0.05 mg/kg ...	1990	2363529
clinical and subclinical colloid goitre in adult camels (camelus dromedarius) at kordofan region of sudan.	colloid goitre was diagnosed in adult camels in the kordofan region of the sudan. the disease is characterized by gross enlargement of the thyroid, histopathological follicular changes, reproductive disorders, low concentrations of circulating thyroid hormones (t3, t4) and normocytic normochromic anaemia. the possible cause of the condition is discussed and iodine supplementation is recommended.	1990	2364252
anaesthesia, not surgical stress, induces increases in serum concentrations of reverse triiodothyronine and thyroxine during surgery.	effects of anaesthesia on serum concentrations of thyroid hormones during and soon after abdominal surgery were examined in 29 patients undergoing cholecystectomy (n = 22) or removal of gastric cancer (n = 7). they were given one of the following anaesthetics in combination with nitrous oxide in oxygen: epidural bupivacaine, enflurane, pentazocine, ketamine, halothane, epidural bupivacaine and enflurane. regardless of type of anaesthesia, t3 decreased significantly during and after surgery. t4 a ...	1990	2365019
thyroid hormone binding inhibition in critically ill patients--who is the inhibitor?	in 31 severely ill patients of our intensive care unit an increased thyroid hormone binding inhibition detected by quantitative measurement of the effect of ether extracts of patients' sera on thyroxine tracer binding to tbg was found. as free fatty acids in serum were diminished in these patients, their postulated role as binding inhibitors in the "low t4 syndrome" of critically ill patients must be questioned. it cannot be excluded that thbi assays demonstrating this inhibition measure artefac ...	1990	2365022
effects of thyroidal, gonadal and adrenal hormones on tissue respiration of streaked frog, rana limnocharis, at low temperature.	in vivo and in vitro effects of thyroidal, gonadal and adrenal hormones were studied on the rate of liver and skeletal muscle respiration in both the sexes of r. limnocharis during active and inactive phases of the annual activity cycle. triiodothyronine (l-t3) and thyroxine (l-t4) did not stimulate tissue (liver and muscle) respiration in any of the experiments irrespective of season, sex and temperature. testosterone, estradiol and corticosterone stimulated o2 uptake significantly irrespective ...	1990	2365405
thyroid iodine content and serum thyroglobulin level following external irradiation to the neck for hodgkin's disease.	fifty-four clinically euthyroid patients were evaluated 1 up to 17 yr after external irradiation to the neck for hodgkin's disease. t4 level was decreased in 6%, while basal tsh level was increased in 44%, and tsh response to trh was increased in 66% of the patients with normal basal tsh level. thyroid iodine content (tic), measured in 50 patients, was below 5 mg in 18. the 29 patients with normal basal tsh level had a mean tic (6.8 +/- 2.7 mg) significantly lower (p less than 0.01) than the con ...	1990	2365955
a study of seroprevalence of hiv-1 and hiv-2 in six provinces of people's republic of angola: clues to the spread of hiv infection.	a seroepidemiological study was carried out to determine the distribution of the human immunodeficiency viruses type 1 (hiv-1) and type 2 (hiv-2) in the people's republic of angola, where hiv-2 existence was previously unknown and hiv-1 seropositivity was only reported to be present in luanda and cabinda. a total of 1,695 serum samples were obtained from healthy persons (control group) and from a group of patients in the provinces of zaire (13), lunda-norte (l.n.) (749), luanda (556), huambo (15 ...	1990	2366148
[procollagen-iii-peptide in bronchoalveolar lavage fluid as an index of fibrosis in sarcoidosis and idiopathic lung fibrosis?].	in order to answer the question whether in sarcoidosis and idiopathic pulmonary fibrosis there is a relationship between the activity of alveolitis (t4/t8 ratio in sarcoidosis, number of granulocytes in idiopathic pulmonary fibrosis) and the activity of connective tissue formation (type iii procollagen peptide in the bal fluid) bal was performed in 12 healthy subjects, 33 patients with type ii sarcoidosis, and 26 patients with idiopathic pulmonary fibrosis. in the unconcentrated bal fluid of the ...	1990	2367369
[discriminatory value of bronchoalveolar lavage parameters in differential diagnosis--exogenous allergic alveolitis, sarcoidosis and patients with healthy lungs].	for this study, the results of 487 bal investigations involving 126 patients with sarcoidosis, 34 patients with exogenous-allergic alveolitis, 18 subjects with healthy lungs, and 309 patients with other pulmonary disorders, were analysed. the diagnoses had been established independently of the bal results. after elimination of interdependent variables, the discriminatory usefulness of the bal parameters: total number of cells, relative percentage of lymphocytes, natural killer cells, and t4/t8 r ...	1990	2367370
[disorders in the hypophysis-adrenal and hypophysis-thyroid systems of patients with acute pneumonia and the ways for their therapeutic correction].	using ria, 188 patients with acute pneumonia were examined over time for the blood acth, cortisol, tth, t3 and t4 content as well as for t4/t3, tth/t3 and tth/t4 correlations. under discussion are causes, approaches to the prevention and correction of the hormonal disorders revealed in the pituitary-adrenal system in patients with an unfavourable course of pneumonia. the majority of the patients manifested thyroid hypofunction and tth hypersecretion, which remained unchanged even during the clin ...	1990	2367990
external radiotherapy in the treatment of tonsillar carcinomas. analysis of 183 cases.	a retrospective analysis of 183 consecutive patients with tonsillar carcinoma observed from 1970 through 1984 and treated by external radiotherapy was carried out. the data were analyzed retrospectively to determine the factors affecting prognosis. tumor size (t) and lymph node involvement (n) were found to be predominant prognostic factors. the difference in 5 year survival rate between t2 and t3 tumors was significant, and that between n1 and n3 was highly significant, whereas difference in su ...	1990	2368168
high prevalence of occult papillary thyroid carcinoma in a surgical series for benign thyroid disease.	in a surgical series of 277 consecutive patients operated on the thyroid for benign diseases, a high prevalence rate (10.5%) of occult papillary carcinoma was found by means of an accurate histologic examination. indications for surgery were euthyroid multinodular goiter in 25 patients, autonomously hyperfunctioning adenoma in 2 and graves' disease in 2 patients. neoplastic foci were unilaterally found in 25 cases but multifocally in 6 and bilaterally in 4 cases: the diameters ranged from 2-10 m ...	1990	2368170
[prognosis and treatment of advanced breast cancer from the surgical viewpoint].	twenty-four patients with advanced mammary carcinoma (stage t4) were treated between 1983-1986 at the department of surgery of the university of bochum, marienhospital herne 1. the primary surgical treatment was supported in 18 cases by an ablatio modified from patey, the ablatio simplex were performed on 4 patients; while a thoracical-epigastric flap was applied to one patient. because of the high percentage (16.6%) of advanced breast cancer on all our breast cancer patients, we feel obliged to ...	1990	2368524
indications for thyroxine therapy after surgery for nontoxic benign goitre.	of 287 consecutive patients, surgically treated at our department for benign, nontoxic goitre during a six-year period, 261 could be followed up, on average, 8.0 years postoperatively. unilateral surgical procedures had been used in 199 patients, subtotal thyroidectomy in 62. 29 patients were treated with thyroxine (t4) immediately postoperatively ("recurrence prophylaxis"); in the other patients thyroxine was only given in cases of hypothyroidism (significant increase of s-tsh). 26 patients had ...	1990	2368548
[ureteral metastasis of carcinoma of the kidney].	involvement of the ureter from metastatic renal cell carcinoma is doubtlessly uncommon. five cases of ureteric secondaries are studied herein. all were ipsilateral and synchronous with the appearance of the primary tumor except for one that was diagnosed 5 years following nephrectomy. the most consistent clinical feature was that of hematuria which presented in all cases. urography (ivp) and retrograde ureteropyelography (rup) proved to be fundamental in the morphologic diagnosis of these lesion ...	1990	2369156
evidence that bovine growth hormone treatment increases the rate of extrathyroidal 5'-monodeiodinase activity in cattle.	this study examined the influence of bovine growth hormone (bgh) on liver and kidney thyroxine-5'-monodeiodinase activity (tma) in growing beef cattle. in a preliminary trial (trial 1), tissue samples were obtained at slaughter from two placebo-injected and two bgh-injected (29.2 iu/day for 14 days before slaughter) hereford heifers (398 kg avg slaughter wt), with one heifer on each treatment fed at either 1.0 or 2.0 times maintenance energy requirement. in a second trial, tissue and plasma samp ...	1990	2369817