Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| targeting the ca(2+) sensor stim1 by exosomal transfer of ebv-mir-bart13-3p is associated with sjögren's syndrome. | primary sjögren's syndrome (pss) is a systemic autoimmune disease that is associated with inflammation and dysfunction of salivary and lacrimal glands. the molecular mechanism(s) underlying this exocrinopathy is not known, although the syndrome has been associated with viruses, such as the epstein barr virus (ebv). we report herein that an ebv-specific microrna (ebv-mir-bart13-3p) is significantly elevated in salivary glands (sgs) of pss patients and we show that it targets stromal interacting m ... | 2016 | 27381477 |
| changing patterns in the epstein-barr virus (ebv)and hodgkin lymphoma association in tunisia. | we compared the features of the epstein-barr virus (ebv) and hodgkin lymphoma (hl) association in tunisia in two periods of time, 1991-2001 (111 cases) and 2002-2012 (122 cases). the investigation of the ebv status by eber in situ hybridization showed a significant decrease in the prevalence of ebv-positive hl from 69.3 % for the period 1991-2001 to 40.1 % for the 2002-2012 period (p = 0.00001). ebv positivity has decreased in all age groups but was more pronounced among young patients, in the 1 ... | 2016 | 27378019 |
| classical hodgkin lymphoma with positive epstein-barr virus status is associated with more foxp3 regulatory t cells. | background classical hodgkin lymphoma (chl) is characterized by sparse malignant hodgkin and reed-sternberg cells dispersed in an inflammatory microenvironment. immune evasion of malignant cells is partially due to the existence of a subpopulation of immunosuppressive regulatory t cells (treg). the aim of this study was to analyze t cell composition in chl with special emphasis on treg in regard to epstein-barr virus (ebv) status, subtype, and patient age. material and methods the study included ... | 2016 | 27377121 |
| late persistent positive ebv viral load and risk of solid cancer in kidney transplant patients. | recent studies reported that posttransplant epstein-barr virus (ebv) replication is frequent and indicates overimmunosuppression. we hypothesized that long-term ebv replication may identify overimmunosuppressed patients at higher risk of cancer. | 2016 | 27367471 |
| prognostic significance of signal transducer and activator of transcription 5 and 5b expression in epstein-barr virus-positive patients with chronic lymphocytic leukemia. | signal transducer and activator of transcription (stat) proteins have been intensively studied in hematologic malignancies, and the efficacy of agents against stats in lymphomas is already under research. we investigated the expression of total stat5 and stat5b in peripheral blood samples of patients with chronic lymphocytic leukemia (cll) in correlation with the presence of epstein-barr virus (ebv) and its major oncoprotein (latent membrane protein 1, lmp1). the ebv load was measured in the per ... | 2016 | 27367207 |
| evaluation of the risk of lymphomagenesis in xenografts by the pcr-based detection of ebv bamhi w region in patient cancer specimens. | establishment of patient-derived tumor xenografts (pdxs) is hampered by lymphomagenesis mostly caused by the latently-infected epstein-barr virus (ebv) contained in patient cancer tissues. however, the character of patient tissues that result in lymphomagenesis after xenotransplantation is not elucidated. in this study, we analyzed the patient colorectal cancer (crc) tissues and the pdxs established by their xenotransplantation. we found that 2 of 9 (22%) pdx tumors were ebv-associated human dif ... | 2016 | 27367028 |
| management of epstein-barr virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: sixth european conference on infections in leukemia (ecil-6) guidelines. | epstein-barr virus-related post-transplant lymphoproliferative disorders are recognized as a significant cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation. to better define current understanding of post-transplant lymphoproliferative disorders in stem cell transplant patients, and to improve its diagnosis and management, a working group of the sixth european conference on infections in leukemia 2015 reviewed the literature, graded the available quali ... | 2016 | 27365460 |
| recurrence of tubulointerstitial nephritis without uveitis, in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. | we report a case of recurrent tubulointerstitial nephritis without uveitis in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. a 26-year-old male patient who had been diagnosed with tubulointerstitial nephritis and uveitis syndrome at 8 years of age developed end-stage renal failure and subsequently underwent living-donor related renal transplant at 17 years old. the 1st recurrence of tubulointerstitial nephritis and uveitis occurred 36 months after tra ... | 2016 | 27364115 |
| epstein-barr virus-associated smooth muscle tumor. | immunodeficient individuals are prone to develop a number of opportunistic infections and unique neoplasms. epstein-barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. it has been described in patients infected with human immunodeficiency virus, in the posttransplant setting, and in those with congenital immunodeficiency. different anatomic sites can be involved by epstein-barr virus-associated smooth muscle tumor, and even multiple locations can c ... | 2016 | 27362573 |
| facial manifestations of epstein-barr virus-related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: two atypical presentations. | epstein-barr virus-related lymphoproliferative disease (ebv-lpd) rarely occurs in patients with acute lymphoblastic leukemia (all), who have not received hematopoietic transplantation. we describe ebv-lpd manifesting as facial lesions in two children with all in remission. one patient was a 16-year-old male with t-cell all with an ebv-positive angiocentric polymorphous lip lesion presenting as right-sided facial swelling. the other patient was a 12-year-old male with b-cell all with an ebv-posit ... | 2016 | 27392033 |
| expression of cdx2 and thyroid transcription factor-1 in oropharyngeal undifferentiated carcinomas: a potential diagnostic pitfall. | oropharyngeal undifferentiated carcinomas are rare and most are human papillomavirus related. morphologically, they overlap with undifferentiated carcinomas from other organ sites, including the nasopharynx, lung, and gastrointestinal tract. most have lymph node metastases at presentation and, especially when initially encountered in a lymph node, immunostains may be performed to determine the most likely primary site. we recently reviewed a case in consultation that strongly and diffusely expre ... | 2016 | 27389559 |
| conjugating prussian blue nanoparticles onto antigen-specific t cells as a combined nanoimmunotherapy. | to engineer a novel nanoimmunotherapy comprising prussian blue nanoparticles (pbnps) conjugated to antigen-specific cytotoxic t lymphocytes (ctl), which leverages pbnps for their photothermal therapy (ptt) capabilities and epstein-barr virus (ebv) antigen-specific ctl for their ability to traffic to and destroy ebv antigen-expressing target cells. | 2016 | 27389189 |
| post-transcriptional regulation of klf4 by high-risk human papillomaviruses is necessary for the differentiation-dependent viral life cycle. | human papillomaviruses (hpvs) are epithelial tropic viruses that link their productive life cycles to the differentiation of infected host keratinocytes. a subset of the over 200 hpv types, referred to as high-risk, are the causative agents of most anogenital malignancies. hpvs infect cells in the basal layer, but restrict viral genome amplification, late gene expression, and capsid assembly to highly differentiated cells that are active in the cell cycle. in this study, we demonstrate that hpv ... | 2016 | 27386862 |
| cytotoxic effects of nf‑κb inhibitors in combination with anti‑herpes agents on epstein‑barr virus‑positive gastric carcinoma in vitro. | epstein-barr virus (ebv) infection in tumor cells is usually restricted to the latent form, indicating that the induction of viral lytic infection may present a novel approach for the treatment of ebv‑associated tumors. by contrast, ebv lytic replication is inhibited by high‑levels of nuclear factor (nf)‑κb, which suggests that nf‑κb inhibitors may activate lytic replication from the latent form. in the current study, the addition of nf‑κb inhibitors (bay11‑7082, z‑llf‑cho and aspirin) was obser ... | 2016 | 27430429 |
| axonal polyneuropathy as an unusual manifestation of acute epstein-barr virus infection in an adult. | 2016 | 27430089 | |
| gene sharing between epstein-barr virus and human immune response genes. | epstein-barr virus (also termed hhv-4, ebv), a component of the human virome or metagenome, is associated as a co-factor in many common human autoimmune diseases through epidemiologic evidence. numerous ebv genes are functional as well as structural homologues of important immune response genes. for example, ebv-encoded bcrf1 is a functional homologue of il-10, a critical cytokine regulator of immune tolerance. bzlf-1, an ebv-encoded transcription factor, contains regions with functional homolog ... | 2016 | 27421718 |
| association of epstein-barr virus (ebv) but not human papillomavirus (hpv) with gingivitis and/or periodontitis in transplanted individuals. | the aim of this study was to investigate the association of ebv and hpv with gingivitis and/or periodontitis according to the immunologic status. to this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by pcr for both viruses. according to the results, ebv was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.011) but not hpv (p = 0.766). ebv-hpv co-detecti ... | 2016 | 27410918 |
| global transcript structure resolution of high gene density genomes through multi-platform data integration. | annotation of herpesvirus genomes has traditionally been undertaken through the detection of open reading frames and other genomic motifs, supplemented with sequencing of individual cdnas. second generation sequencing and high-density microarray studies have revealed vastly greater herpesvirus transcriptome complexity than is captured by existing annotation. the pervasive nature of overlapping transcription throughout herpesvirus genomes, however, poses substantial problems in resolving transcri ... | 2016 | 27407110 |
| the value of circulating cyfra21-1 expression in patients with nasopharyngeal carcinoma: a study of 529 subjects. | early diagnosis of nasopharyngeal carcinoma (npc) needs more reliable biomarkers. the aim of this study was to investigate serum cytokeratin 19 fragment 21.1 (cyfra21-1) as an npc biomarker based on data from a large sample. | 2016 | 27405513 |
| follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of mdm2, somatostatin receptor 2a, and pd-l1. | follicular dendritic cell sarcoma (fdcs) is a rare low-grade neoplasm with the phenotype of fdc cells. this rare sarcoma has been well known for being mistaken for a variety of neoplasms (mainly meningioma), particularly at extranodal sites. diagnosis of fdcs mainly relies on characteristic histologic appearance supplemented by immunohistochemistry and electron microscopy. in this study, we reviewed 15 fdcss retrieved from our consultation files and stained them for newly reported or novel marke ... | 2016 | 27402219 |
| biological and molecular characterization of a rare case of cutaneous richter syndrome. | richter syndrome (rs) is the transformation of chronic lymphocytic leukemia in a high-grade lymphoma usually presenting nodal and bone marrow involvement. richter syndrome can be localized at extranodal sites including the gastrointestinal tract, lungs, and skin. cutaneous rs is an extremely rare disease apparently showing a less aggressive course than common presentations. while nodal rs has been extensively investigated in literature, pathogenesis and prognosis of cutaneous rs are still partia ... | 2016 | 27400669 |
| interleukin (il)-39 [il-23p19/epstein-barr virus-induced 3 (ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. | interleukin (il)-12 family cytokines play critical roles in autoimmune diseases. our previous study has shown that il-23p19 and epstein-barr virus-induced 3 (ebi3) form a new il-12 family heterodimer, il-23p19/ebi3, termed il-39, and knock-down of p19 or ebi3 reduced diseases by transferred gl7(+) b cells in lupus-prone mice. in the present study, we explore further the possible effect of il-39 on murine lupus. we found that il-39 in vitro and in vivo induces differentiation and/or expansion of ... | 2016 | 27400195 |
| a nomogram for predicting survival of nasopharyngeal carcinoma patients with metachronous metastasis. | patients with metachronous metastatic nasopharyngeal carcinoma (npc) differ significantly in survival outcomes. the aim of this study is to build a clinically practical nomogram incorporating known tumor prognostic factors to predict survival for metastatic npc patients in epidemic areas.a total of 860 patients with metachronous metastatic nasopharyngeal carcinoma were analyzed retrospectively. variables assessed were age, gender, body mass index, karnofsky performance status (kps), union for in ... | 2016 | 27399084 |
| increased epstein-barr virus in breast milk occurs with subclinical mastitis and hiv shedding. | epstein-barr virus (ebv) in breast milk and subclinical mastitis (scm) are both associated with human immunodeficiency virus (hiv) shedding and possibly with postnatal hiv transmission. the objective of this nested case-control study was to investigate the interplay between scm and ebv replication in breast milk of hiv-infected mothers.the relationships between ebv deoxyribonucleic acid (dna) shedding, hiv-1 ribonucleic acid (rna) level, and scm were explored in breast milk samples of zambian mo ... | 2016 | 27399077 |
| the effect of self-reported health on latent herpesvirus reactivation and inflammation in an ethnically diverse sample. | self-rated health (srh) is a reliable predictor of health outcomes including morbidity and mortality. immune dysregulation is one hypothesized mechanism underlying the association between srh and health outcomes. indeed, poorer srh is associated with greater inflammation. the association between srh and reactivation of latent herpesviruses is unknown, representing an important gap in the literature given that reactivation of latent herpesviruses leads to enhanced inflammation. the present study ... | 2016 | 27398881 |
| fine specificity of the antibody response to epstein-barr nuclear antigen-2 and other epstein-barr virus proteins in patients with clinically isolated syndrome: a peptide microarray-based case-control study. | we analyzed the fine specificity of antibodies to epstein-barr nuclear antigen-2 (ebna-2) and other epstein-barr virus (ebv) proteins in 29 patients with clinically isolated syndrome (cis, the first clinical manifestation of multiple sclerosis [ms]) and 29 controls with a peptide microarray containing 117 overlapping peptides representing the full-length ebna-2 protein and 71 peptides from 8 further ebv proteins. while ebv peptide antibodies were elevated in cis, suggesting that ebv contributes ... | 2016 | 27397076 |
| [research advances in target genes of epstein-barr virus-encoded micrornas]. | the epstein-barr virus (ebv) is a gamma herpes virus associated with several types of malignancies. the ebv encodes viral micrornas (mirnas) that can target genes within cells. the ebv participates in signal transduction as well as the proliferation and differentiation of cells. how the target genes and functions of ebv-encoded mirnas contribute to the pathogenesis of ebv is an important research topic. some target genes have been validated since ebv-encoded mirnas were discovered and, in this a ... | 2016 | 27396169 |
| pancreatitis and cholecystitis in primary acute symptomatic epstein-barr virus infection - systematic review of the literature. | acute pancreatitis and acalculous cholecystitis have been occasionally reported in primary acute symptomatic epstein-barr virus infection. we completed a review of the literature and retained 48 scientific reports published between 1966 and 2016 for the final analysis. acute pancreatitis was recognized in 14 and acalculous cholecystitis in 37 patients with primary acute symptomatic epstein-barr virus infection. in all patients, the features of acute pancreatitis or acalculous cholecystitis concu ... | 2016 | 27434148 |
| microrna-183 suppresses cancer stem-like cell properties in ebv-associated nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is an epstein-barr virus (ebv)-associated epithelial malignancy that exhibits distinct geographical and ethnic prevalence. although the contemporary therapeutic approach of radio-/chemotherapy provides excellent results for patients with early-stage disease, it is far from satisfactory for those with disease remission and distant metastasis. promising therapeutic strategies for advanced and relapsed npc are still lacking. we recently identified and characterized a ... | 2016 | 27431799 |
| epstein-barr virus-negative diffuse large b cell lymphoma with aberrant expression of cd3 and other t cell-associated antigens: report of three cases with a review of the literature. | expression of cd3 on a mature b cell neoplasm, such as diffuse large b cell lymphoma (dlbcl), is extremely rare. when it is present, it will cause diagnostic confusion since the classification of lymphoid neoplasms is largely based on immunophenotyping to determine the cell lineage. we report three cases of dlbcl with cd3 and other t cell-associated antigens. a literature search identifies 30 additional cases of dlbcl expressing cd3, with the majority (78.6 %) displaying cytoplasmic expression, ... | 2016 | 27431583 |
| a central role for stat3 in gammaherpesvirus-life cycle and -diseases. | having co-evolved with humans, herpesviruses have adapted to exploit the host molecular machinery to ensure viral persistence. the cellular protein signal transducer and activator of transcription 3 (stat3) is a leading example. stat3 is a prominent transcription factor that functions in a variety of physiologic processes including embryonic development, inflammation, immunity, and wound healing. generally activated via growth factor and cytokine signaling, stat3 can transcriptionally drive onco ... | 2016 | 27458446 |
| salivary and serum il-10, tnf-α, tgf-β, vegf levels in oropharyngeal squamous cell carcinoma and correlation with hpv and ebv infections. | each year approximately 6,000 new cases of head and neck cancer are registered in poland. human papillomavirus (hpv) and epstein-barr virus (ebv) have been associated with tumour formation. cytokines have been shown to play an important role both in inflammation and carcinogenesis and they can be detected in saliva and serum with elisa assays. salivary biomarkers may be used as markers of early cancer detection. the aim of this study was the analysis of the serum and salivary levels of il-10, tn ... | 2016 | 27547238 |
| [transformation of patient-derived tumor xenografts into lymphomas: characteristics, influence factors and precautions]. | the patient-derived tumor xenografts (pdx) model is an animal model established by directly engrafting fresh tumor tissue of patients into immunodeficiency mice after surgery or biopsy, which plays an important role in the study of tumor biology. however, the transformation of pdx into lymphoma limits the application of this model. the characters of this transformation include that epithelial tumors origin, predorminance of b-cell lymphomas, lost of architectural feature of primary tumor, absenc ... | 2016 | 27452762 |
| approach for identifying human leukocyte antigen (hla)-dr bound peptides from scarce clinical samples. | immune-mediated diseases strongly associating with human leukocyte antigen (hla) alleles are likely linked to specific antigens. these antigens are presented to t cells in the form of peptides bound to hla molecules on antigen presenting cells, e.g. dendritic cells, macrophages or b cells. the identification of hla-dr-bound peptides presents a valuable tool to investigate the human immunopeptidome. the lung is likely a key player in the activation of potentially auto-aggressive t cells prior to ... | 2016 | 27452731 |
| uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen. | autoantibodies mediate organ destruction in multiple autoimmune diseases, yet their origins in patients remain poorly understood. to probe the genetic origins and structure of disease-associated autoantibodies, we engrafted immunodeficient mice with human cd34+ hematopoietic stem cells and immunized with the non-collagenous-1 (nc1) domain of the alpha3 chain of type iv collagen. this antigen is expressed in lungs and kidneys and is targeted by autoantibodies in anti-glomerular basement membrane ... | 2016 | 27450516 |
| correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis. | differential overall survival of nasopharyngeal carcinoma (npc) with different organ site metastases has been documented. here, we attempted to determine the underlying mechanisms by assessing plasma and tumor tissue markers in relation to patient survival. pretreatment plasma epstein-barr virus (ebv) dna concentrations, cytokines and tissue macrophages, proliferation and apoptosis markers were determined in 178 patients with metastatic npc. the median overall survival (os) was 19 months. patien ... | 2016 | 27448966 |
| ebv-negative monomorphic b-cell post-transplant lymphoproliferative disorders are pathologically distinct from ebv-positive cases and frequently contain tp53 mutations. | monomorphic post-transplant lymphoproliferative disorder commonly resembles diffuse large b-cell lymphoma or burkitt lymphoma, and most are epstein-barr virus (ebv) positive. we retrospectively identified 32 cases of monomorphic post-transplant lymphoproliferative disorder from two institutions and evaluated ebv in situ hybridization; tp53 mutation status; p53, cd30, myc, and bcl2 expression by immunohistochemistry; proliferation index by ki67; and germinal center vs non-germinal center immunoph ... | 2016 | 27443517 |
| short chain fatty acids (scfa) reprogram gene expression in human malignant epithelial and lymphoid cells. | the effect of short chain fatty acids (scfas) on gene expression in human, malignant cell lines was investigated, with a focus on signaling pathways. the commensal microbial flora produce high levels of scfas with established physiologic effects in humans. the most abundant scfa metabolite in the human microflora is n-butyric acid. it is well known to activate endogenous latent epstein-barr virus (ebv), that was used as a reference read out system and extended to ebv+ epithelial cancer cell line ... | 2016 | 27441625 |
| epstein-barr virus oncoprotein lmp1 mediates epigenetic changes in host gene expression through parp1. | the latent infection of epstein-barr virus (ebv) is associated with 1% of human cancer incidence. poly(adp-ribosyl)ation (parylation) is a posttranslational modification catalyzed by poly(adp-ribose) polymerases (parps) that mediate ebv replication during latency. in this study, we detail the mechanisms that drive cellular parylation during latent ebv infection and the effects of parylation on host gene expression and cellular function. ebv-infected b cells had higher par levels than ebv-negativ ... | 2016 | 27440880 |
| epstein-barr virus barf1-induced nfκb/mir-146a/smad4 alterations in stomach cancer cells. | epstein-barr virus (ebv)-encoded bamhi-a rightward frame 1 (barf1) is a putative viral oncogene in ebv-infected stomach cancer. the aim of the present study was to investigate barf1-induced cellular protein and microrna alterations. in this study, barf1-expressing stomach cancer cells showed a high rate of proliferation, high levels of nfκb, and mir-146a upregulation, which was reversed by nfκb knockdown. during barf1-induced nfκb upregulation, hcsf1 receptor level was unchanged. knockdown of ba ... | 2016 | 27438138 |
| subcutaneous panniculitis-like t-cell lymphoma: a rare tumour. | subcutaneous panniculitis like t cell lymphoma (sptcl) is an uncommon variant and poorly differentiated type of cutaneous t cell lymphoma. here we describe the case of a 19-year-old female who presented with swelling of left half of the face with no regional lymphadenopathy and hepatosplenomegaly which was initially misdiagnosed as a benign cutaneous condition by various practitioners. histopathological examination revealed diffuse infiltration of subcutaneous plane by small to medium sized atyp ... | 2016 | 27437288 |
| chronic epstein barr virus infection leading to classical hodgkin lymphoma. | chronic epstein barr virus (ebv) infection in an immunocompetent host has been described however it is not a common entity. it has been linked to many lymphoproliferative disorders and achieves such via many molecular mechanisms, some of which are poorly understood. in addition to infectious mononucleosis, the ebv is linked to various other hematological pathologies and autoimmune disorders. | 2016 | 27437106 |
| a collaborative study to establish the 1st who international standard for epstein-barr virus for nucleic acid amplification techniques. | variability in viral load measurements using nucleic acid amplification techniques (nat) has a significant impact on the management of epstein-barr virus (ebv)-associated diseases, and has highlighted a need for standardisation of these measurements. the aim of this collaborative study was to evaluate the suitability of a range of candidate reference materials to harmonise ebv viral load measurements in a wide range of nat assays. candidate materials included lyophilised and liquid whole virus p ... | 2016 | 27461128 |
| novel hdad/ebv reprogramming vector and highly efficient ad/crispr-cas sickle cell disease gene correction. | crispr/cas enhanced correction of the sickle cell disease (scd) genetic defect in patient-specific induced pluripotent stem cells (ipscs) provides a potential gene therapy for this debilitating disease. an advantage of this approach is that corrected ipscs that are free of off-target modifications can be identified before differentiating the cells into hematopoietic progenitors for transplantation. in order for this approach to be practical, ipsc generation must be rapid and efficient. therefore ... | 2016 | 27460639 |
| epidemiology of major neurodegenerative diseases in women: contribution of the nurses' health study. | to review the contribution of the nurses' health study (nhs) to identifying the role of lifestyle, diet, and genetic or biological factors in several neurodegenerative diseases, including cognitive decline, multiple sclerosis, parkinson's disease, and amyotrophic lateral sclerosis. | 2016 | 27459462 |
| association between acute infectious mononucleosis and vitamin d deficiency. | epstein-barr virus and vitamin d both have been implicated in the pathogenesis of autoimmune diseases, especially multiple sclerosis (ms). vitamin d influences both innate and adaptive immune responses and has been linked to increased susceptibility to other viral infections such as influenza. here we aimed to examine the association between vitamin d and acute infectious mononucleosis (im).this study is a case-control study that was conducted on im patients and a control group of healthy indivi ... | 2016 | 27505106 |
| increased ex vivo antigen presentation profile of b cells in multiple sclerosis. | multiple sclerosis (ms) is thought to be t cell mediated but the mechanisms eliciting such a dysregulated adaptative immune response remain enigmatic. | 2016 | 27503907 |
| kinetics of alloantigen-specific regulatory cd4 t cell development and tissue distribution after donor-specific transfusion and costimulatory blockade. | the influence of donor-side regulation toward recipient antigens on graft outcome is poorly understood. | 2016 | 27500263 |
| epstein-barr virus-positive posttransplant lymphoproliferative disease after solid organ transplantation: pathogenesis, clinical manifestations, diagnosis, and management. | posttransplant lymphoproliferative disease (ptld) is a potentially fatal complication after (solid organ) transplantation, which is highly associated with epstein-barr virus (ebv). the ebv-specific cytotoxic t cell response that is essential in controlling the virus in healthy individuals is suppressed in transplant recipients using immunosuppressive drugs. a primary ebv infection in ebv-seronegative patients receiving an ebv-seropositive donor organ or a reactivation in those who are already la ... | 2016 | 27500242 |
| chromatin remodeling factor lsh affects fumarate hydratase as a cancer driver. | cancer metabolism and epigenetic alteration are two critical mechanisms for tumorigenesis and cancer progression; however, the dynamic interplay between them remains poorly understood. as reported in the article entitled "chromatin remodeling factor lsh drives cancer progression by suppressing the activity of fumarate hydratase," which was recently published in cancer research, our group examined the physiological role of lymphocyte-specific helicase (lsh) in nasopharyngeal carcinoma (npc) by fo ... | 2016 | 27473869 |
| prognostic value of neoadjuvant chemotherapy in locoregionally advanced nasopharyngeal carcinoma with low pre-treatment epstein-barr virus dna: a propensity-matched analysis. | the aim of this study is to investigate the prognostic value of neoadjuvant chemotherapy (nct) in locoregionally advanced nasopharyngeal carcinoma (npc) with low pre-treatment epstein-barr virus (ebv) dna in the era of intensity-modulated radiotherapy (imrt). | 2016 | 27471562 |
| computational discovery of epstein-barr virus targeted human genes and signalling pathways. | epstein-barr virus (ebv) plays important roles in the origin and the progression of human carcinomas, e.g. diffuse large b cell tumors, t cell lymphomas, etc. discovering ebv targeted human genes and signaling pathways is vital to understand ebv tumorigenesis. in this study we propose a noise-tolerant homolog knowledge transfer method to reconstruct functional protein-protein interactions (ppi) networks between epstein-barr virus and homo sapiens. the training set is augmented via homolog instan ... | 2016 | 27470517 |
| beyond epstein-barr virus: genetic predisposition of natural killer t-cell lymphoma. | 2016 | 27470080 | |
| genetic risk of extranodal natural killer t-cell lymphoma: a genome-wide association study. | extranodal natural killer t-cell lymphoma (nktcl), nasal type, is a rare and aggressive malignancy that occurs predominantly in asian and latin american populations. although epstein-barr virus infection is a known risk factor, other risk factors and the pathogenesis of nktcl are not well understood. we aimed to identify common genetic variants affecting individual risk of nktcl. | 2016 | 27470079 |
| diagnostic value of serum epstein-barr virus capsid antigen-iga for nasopharyngeal carcinoma: a meta-analysis based on 21 studies. | epstein-barr virus capsid antigen immunoglobulin a (ebv vca-iga) exerts an important role in the diagnosis of nasopharyngeal carcinoma (npc). this meta-analysis aimed to evaluate the pooled diagnostic performance of vca-iga for npc. | 2016 | 27468579 |
| the ubiquitin ligase itch and ubiquitination regulate bfrf1-mediated nuclear envelope modification for epstein-barr virus maturation. | the cellular endosomal sorting complex required for transport (escrt) was recently found to mediate important morphogenesis processes at the nuclear envelope (ne). we previously showed that the epstein-barr virus (ebv) bfrf1 protein recruits the escrt-associated protein alix to modulate ne structure and promote ebv nuclear egress. here, we uncover new cellular factors and mechanisms involved in this process. bfrf1-induced ne vesicles are similar to those observed following ebv reactivation. bfrf ... | 2016 | 27466427 |
| hodgkin lymphoma: pathology and biology. | the hodgkin and reed-sternberg (hrs) tumor cells of classical hodgkin lymphoma (hl), as well as the lymphocyte predominant (lp) cells of nodular lymphocyte predominant hl (nlphl), are derived from mature b cells. however, hrs cells have largely lost their b-cell phenotype and show a very unusual expression of many markers of other hematopoietic cell lineages, which aids in the differential diagnosis between classical hl (chl) and nlphl and distinguishes chl from all other hematopoietic malignanc ... | 2016 | 27496304 |
| fulminant epstein-barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. | we describe a rare fulminant case of epstein-barr virus-associated hemophagocytic syndrome (hps) in a 37-year-old female renal transplant patient, indistinguishable from severe sepsis clinically and in the laboratory. hps involves rapidly escalating immune system activation, resulting in a cytokine cascade, which can, especially in immunocompromised patients, lead to multi-organ failure, and even death. thirty-two herpesviridae-associated hps cases in renal transplant patients have been reported ... | 2016 | 27496079 |
| early diagnosis and follow-up of chronic active epstein-barr-virus-associated cardiovascular complications with cardiovascular magnetic resonance imaging: a case report. | chronic active epstein-barr virus (ebv) infection (caebv) is characterized as chronic or recurrent mononucleosis-like symptoms and elevated ebv deoxyribonucleic acid (ebv-dna) copies. cardiovascular complications have high morbidity and mortality. the treatment regimen for caebv has not been established yet, resulting in poor prognoses. herein, we present a case of cardiovascular magnetic resonance imaging (cmri) evaluation with a series of sequences for caebv-associated cardiovascular involveme ... | 2016 | 27495050 |
| extranodal nk/t cell lymphoma causing cardiorespiratory failure. | extranodal nk/t cell lymphoma is an uncommon malignancy usually involving the sinonasal area. we report an unusual case of extranodal nk/t cell lymphoma diagnosed in a 62-year-old caucasian male who died of progressive cardiorespiratory failure but had no clinically detectable upper respiratory system lesions. the initial diagnosis was made cytologically on a sample of pericardial fluid that contained neoplastic lymphoid cells. these cells were positive for cd2, cytoplasmic cd3, and epstein-barr ... | 2016 | 27493813 |
| x-linked inhibitor of apoptosis complicated by granulomatous lymphocytic interstitial lung disease (glild) and granulomatous hepatitis. | the x-linked inhibitor of apoptosis (xiap) deficiency is a primary immunodeficiency characterized by epstein-barr virus (ebv)-driven hemophagocytic lymphohistiocytosis (hlh), splenomegaly, and colitis. here, we present, for the first time, granulomatous hepatitis and granulomatous and lymphocytic interstitial lung disease (glild) as manifestations of xiap deficiency. we report successful treatment of glild in xiap deficiency with rituximab and azathioprine and discuss the role of xiap deficiency ... | 2016 | 27492372 |
| lymphoma secondary to congenital and acquired immunodeficiency syndromes at a turkish pediatric oncology center. | the prevalence of lymphoma in primary immunodeficiency cases and autoimmune diseases, as well as on a background of immunodeficiency following organ transplants, is increasing. the lymphoma treatment success rate is known to be a low prognosis. our study aimed to emphasize the low survival rates in immunodeficient vs. immunocompetent lymphoma patients and also to investigate the effect of rituximab in patients with ataxia telangiectasia and other immunodeficiencies. we summarized the clinical ch ... | 2016 | 27492260 |
| [errors in diagnosis and treatment of immunodependent pathology (original concept)]. | based on many years of experience in 2009, we developed the original concept of a mixed approach to the treatment of infectious diseases in patients. during 2.5 years(from 2013 to june 2015) to have applied for consultative-diagnostic help of 3965 patients who had not verified the primary diagnosis. the basic principle of verification of the pathology of the removal of various causes immunosuppression. based on our extensive, research and observation was often found in patients ascaridosis (55%) ... | 2016 | 27491144 |
| myc activation and bcl2l11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs. | lymphomagenesis in the presence of deregulated myc requires suppression of myc-driven apoptosis, often through downregulation of the pro-apoptotic bcl2l11 gene (bim). transcription factors (ebnas) encoded by the lymphoma-associated epstein-barr virus (ebv) activate myc and silence bcl2l11. we show that the ebna2 transactivator activates multiple myc enhancers and reconfigures the myc locus to increase upstream and decrease downstream enhancer-promoter interactions. ebna2 recruits the brg1 atpase ... | 2016 | 27490482 |
| a clinicopathological study of primary central nervous system lymphomas & their association with epstein-barr virus. | primary central nervous system lymphomas (pcnsls) are relatively uncommon, accounting for 2-3 per cent of primary brain tumours. majority of these are diffuse large b cell lymphomas (dlbcl) occurring both in immunocompromised and immunocompetent patients. we undertook this study to classify pcnsl into germinal centre (gc) and non-germinal centre (ngc) type based on hans classification and to find the role of epstein-barr virus (ebv) in pathogenesis both by conventional immunohistochemistry (ihc) ... | 2016 | 27488004 |
| cxcr5(+) follicular cytotoxic t cells control viral infection in b cell follicles. | during unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (hiv), which persists in follicular helper t cells (tfh cells), and epstein-barr virus (ebv), which persists in b cells. here we identified a specialized group of cytotoxic t cells (tc cells) that expressed the chemokine receptor cxcr5, selectively entered b cell follicles and eradicated infected tfh cells and b cells. the differ ... | 2016 | 27487330 |
| ablation of stat3 in the b cell compartment restricts gammaherpesvirus latency in vivo. | a challenging property of gammaherpesviruses is their ability to establish lifelong persistence. the establishment of latency in b cells is thought to involve active virus engagement of host signaling pathways. pathogenic effects of these viruses during latency or following reactivation can be devastating to the host. many cancers, including those associated with members of the gammaherpesvirus family, kaposi's sarcoma-associated herpesvirus and epstein-barr virus, express elevated levels of act ... | 2016 | 27486189 |
| epstein-barr virus infection and opisthorchiasis: a story of cholangiocarcinoma in the highly endemic area. | 2016 | 27482325 | |
| oral environment and cancer. | cancer is now the leading cause of death in japan. a rapid increase in cancer mortality is expected as japan is facing a super-aged society. many causes of cancer are known to be closely linked to life style factors, such as smoking, drinking, and diet. the oral environment is known to be involved in the pathogenesis and development of various diseases such as bronchitis, pneumonia, diabetes, heart disease, and dementia. because the oral cavity acts as the bodily entrance for air and food, it is ... | 2016 | 27482300 |
| [clinical features and prognosis of cd20-positive classical hodgkin lymphoma]. | to explore the clinical characteristics and prognosis of cd20-positive classical hodgkin lymphoma (chl). | 2016 | 27480653 |
| [an analysis of risk factors and prognosis of epstein-barr virus infection after allogeneic hematopoietic stem cell transplantation]. | to analyze the incidence of epstein-barr virus (ebv) infection in patients after allogeneic hematopoietic stem cell transplantation (hsct), and investigate its risk factors and prognosis. | 2016 | 27480556 |
| the safety and immunological effects of rad5-ebv-lmp2 vaccine in nasopharyngeal carcinoma patients: a phase i clinical trial and two-year follow-up. | epstein-barr virus (ebv)-encoded latent membrane protein 2 (lmp2) promotes nasopharyngeal carcinoma (npc) progression. previously, we reported that the dendritic cells (dcs) transfected with ebv-lmp2 recombinant serotype 5 adenoviruses (rad5) induced anti-tumor effect by eliciting cytotoxic t lymphocytes (ctls)-mediated immune response in vitro and the adenoviral vaccine of ebv-lmp2 (rad5-ebv-lmp2) stimulated antigen-specific cellular immunity in mice. however, the safety and immunological effec ... | 2016 | 27477649 |
| spleen tyrosine kinase: a crucial player and potential therapeutic target in renal disease. | spleen tyrosine kinase (syk), a 72 kda cytoplasmic non-receptor protein-tyrosine kinase, plays an important role in signal transduction in a variety of cell types. ever since its discovery in the early 1990s, there has been accumulating evidence to suggest a pathogenic role of syk in various allergic disorders, autoimmune diseases and malignancies. additionally, there is emerging data from both pre-clinical and clinical studies that syk is implicated in the pathogenesis of proliferative glomerul ... | 2016 | 27476075 |
| [immunotherapy for epstein-barr virus-associated disorders]. | 2016 | 27510880 | |
| [principle suggestions for diagnosis and treatment of main nontumorous epstein-barr virus-associated diseases in children]. | 2016 | 27510866 | |
| [attach importance to diseases associated with severe epstein-barr virus infection in children]. | 2016 | 27510865 | |
| expression of epstein barr virus encoded ebna1 and lmp1 oncoproteins in nasopharyngeal carcinomas from northeast india. | nasopharyngeal carcinoma (npc), a malignancy arising from the epithelial lining of the nasopharynx, is distinct from others cancers in terms of its epidemiologic features. it is rare in most parts of the world except for a few regions with populations of mongoloid origin. | 2016 | 27509984 |
| [viral superantigens]. | superantigens (sags) are microbial proteins produced by various microorganisms that elicit excessive and strong stimulation of t cells via an unconventional mechanism. they cause polyclonal activation of t cells in a non-specific manner, by binding to a particular variable-beta (vβ) chain of t-cell receptor (tcr) and mhc class ii molecule, in unprocessed form and outside of peptide-binding cleft, forming a bridge between the antigen presenting cell and the t cell. sags are classified into three ... | 2016 | 27525406 |
| comparative outcomes after haploidentical or unrelated donor bone marrow or blood stem cell transplantation in adult patients with hematological malignancies. | most patients eligible for allogeneic hematopoietic stem cell transplantation will require identification of an alternate (unrelated or mismatched related) donor. we explored the transplantation outcomes for a sequential series of 54 patients undergoing haploidentical donor transplantation (haplo) compared to those from a control group of patients receiving cells from matched or mismatched unrelated donors (urd) selected by diagnosis and stem cell source. patients undergoing haplo transplantatio ... | 2016 | 27522040 |
| chloroquine inhibits lytic replication of kaposi's sarcoma-associated herpesvirus by disrupting mtor and p38-mapk activation. | lytic infection is essential for the persistent infection and pathogenesis of kaposi's sarcoma-associated herpesvirus (kshv), and inhibiting kshv lytic replication may effectively prevent the occurrence of kshv-related diseases. chloroquine (cq), a well-known antimalarial drug and autophagy inhibitor, exerts broad-spectrum antiviral effects and shows anti-cancer therapeutic potential. however, the ability of cq and its derivatives to control infection of oncogenic γ-herpesvirus remains undefined ... | 2016 | 27521848 |
| increased levels of plasma epstein barr virus dna identify a poor-risk subset of patients with advanced stage cutaneous t-cell lymphoma. | outcomes in advanced stage (as) cutaneous t-cell lymphomas (ctcl) are poor but with great variability. epstein-barr virus (ebv) is associated with a subset of non-hodgkin lymphomas. frequency of plasma ebv-dna (pebvd) detection, concordance with ebv rna (eber) in tumor tissue, codetection of plasma cytomegalovirus dna (pcmvd), and prognostic effect in as ctcl are unknown. | 2016 | 27521316 |
| nasopharyngeal carcinoma risk prediction via salivary detection of host and epstein-barr virus genetic variants. | genetic susceptibility and epstein-barr virus (ebv) infection are important etiological factors in nasopharyngeal carcinoma (npc). in this study, in southern china, where npc is endemic, a single nucleotide polymorphism (snp) in the ebv-encoded rpms1 gene (locus 155391: g > a [g155391a]) and seven host snps (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were confirmed to be significantly associated with npc risk in 50 npc cases versus 54 hospital-based controls ... | 2016 | 27517745 |
| unusual presentation of pulmonary lymphoepithelioma-like carcinoma. | primary pulmonary lymphoepithelioma-like carcinoma (lelc) is a rare malignant tumour with histological features similar to undifferentiated nasopharyngeal carcinoma. a close association is known to exist between pulmonary lelc and epstein-barr virus infection in southeast asian countries. we report a 69-year-old man with pulmonary lelc arising from a thin-walled cavity with a smooth inner surface and characterized by an unexpectedly rapid progression. | 2016 | 27516893 |
| absolute configuration of dihydro-β-agarofuran sesquiterpenes from maytenus jelskii and their potential antitumor-promoting effects. | chemoprevention of human cancer appears to be a feasible strategy for cancer control, especially when chemopreventive intervention is involved during early stages of the carcinogenesis process. as a part of our ongoing research program into new chemopreventive agents, herein are reported the isolation, structural elucidation, and biological evaluation of 10 new (1-10) and three known (11-13) sesquiterpenes with a dihydro-β-agarofuran skeleton from the leaves of maytenus jelskii zahlbr. their ste ... | 2016 | 27541714 |
| case report: epstein-barr-virus negative diffuse large b-cell lymphoma detected in a peri-prosthetic membrane. | primary bone lymphomas (pbl) are extremely rare malignant neoplasms. the most commonly described subtype of pbl is diffuse large b-cell lymphoma (dlbcl). dlbcl within peri-prosthetic membrane of a joint is exceedingly rare. to the best of our knowledge this case is the second reported epstein-bar-virus (ebv) negative dlbcl in a peri-prosthetic membrane in the literature. | 2016 | 27539226 |
| birth order and risk of nasopharyngeal carcinoma in multiplex families from taiwan. | a small proportion of individuals infected with epstein-barr virus (ebv) develop nasopharyngeal carcinoma (npc). timing of initial exposure could alter immunological responses to primary ebv infection and explain variation in cancer risk later in life. we measured early life family structure as a proxy for the timing of primary ebv infection to examine whether earlier age at infection alters npc risk. we utilized data from 480 npc cases and 1,291 unaffected siblings from taiwanese npc multiplex ... | 2016 | 27537611 |
| establishing and characterizing a new primary effusion lymphoma cell line harboring kaposi's sarcoma-associated herpesvirus. | primary effusion lymphoma is a rare distinct large b-cell neoplasm that is associated with kaposi's sarcoma-associated herpesvirus (kshv) infection. over recent years, 9 kshv-positive/epstein-barr virus (ebv)-negative pel cell lines have been established. | 2016 | 27536332 |
| association of single nucleotide polymorphism rs2065955 of the filaggrin gene with susceptibility to epstein-barr virus-associated gastric carcinoma and ebv-negative gastric carcinoma. | the relationship between the filaggrin gene (flg) rs2065955 polymorphism and susceptibility to epstein-barr virus (ebv)-associated gastric carcinoma (ebvagc) and ebv-negative gastric carcinoma (ebvngc) was investigated in shandong province, china. we detected the flg rs2065955 genotype and allele distribution by using pcr and restriction fragment length polymorphism (rflp) in 64 ebvagc, 82 ebvngc, and 111 normal control samples. immunohistochemistry was used to detect the level of flg protein in ... | 2016 | 27535066 |
| the other side of the coin: leveraging epstein-barr virus in research and therapy. | epstein-barr virus is (ebv) a ubiquitous virus prevalent in 90% of the human population. transmitted through infected saliva, ebv is the causative agent of infectious mononucleosis (im) and is further implicated in malignancies of lymphoid and epithelial origins. in the past few decades, research efforts primarily focused on dissecting the mechanism of ebv-induced oncogenesis. here, we present an alternate facet of the oncovirus ebv, on its applications in research and therapy. finally, discussi ... | 2016 | 27531881 |
| prognostic efficacy of combining tumor volume with epstein-barr virus dna in patients treated with intensity-modulated radiotherapy for nasopharyngeal carcinoma. | to evaluate the prognostic effect of combining tumor volume with pre-treatment plasma epstein-barr virus dna (ebv dna) in patients treated with intensity-modulated radiotherapy (imrt) for nasopharyngeal carcinoma (npc). | 2016 | 27531868 |
| hydroa vacciniforme and hydroa vacciniforme-like t-cell lymphoma: an uncommon event for transformation. | hydroa vacciniforme (hv) is associated with epstein-barr virus (ebv) infection and a risk of transformation to lymphoma. | 2016 | 27531667 |
| comprehensive profiling of functional epstein-barr virus mirna expression in human cell lines. | epstein-barr virus (ebv) establishes lifelong infections in its human host. the virus is associated with a broad range of malignancies of lymphoid and epithelial origin, including burkitt's lymphoma, post-transplant lymphoproliferative disease, nasopharyngeal carcinoma and gastric carcinoma. during the latent phase of its life cycle, ebv expresses more than 40 mature mirnas that are highly abundant in tumor cells and may contribute to oncogenesis. although multiple studies have assessed the rela ... | 2016 | 27531524 |
| early developmental exposures shape trade-offs between acquired and innate immunity in humans. | life history theory predicts resource allocation trade-offs between competing functions and processes. we test the hypothesis that relative investment towards innate versus acquired immunity in humans is subject to such trade-offs and that three types of early developmental exposures are particularly salient in shaping adult immunophenotype: (i) pathogen exposure, (ii) nutritional resources; and (iii) extrinsic mortality cues. | 2016 | 27530543 |
| [a case of acute acalculous cholecystitis during infectious mononucleosis caused by the epstein-barr virus in a young woman]. | infection with the epstein-barr virus (ebv) is a common disease and is mainly asymptomatic during childhood, whereas infectious mononucleosis with clinical signs such as fever, pharyngitis, lymphadenopathy and hepatosplenomegaly often occurs in adolescents and adults with primary infection. acalculous cholecystitis has been reported as a rare complication. we report herein a case of acalculous cholecystitis accompanied by infectious mononucleosis by ebv, which was treated successfully by medical ... | 2016 | 27529970 |
| thyrotropin receptor antibody (trab)-igm levels are markedly higher than trab-igg levels in graves' disease patients and controls, and trab-igm production is related to epstein-barr virus reactivation. | graves' disease is an autoimmune thyroid disorder that mainly presents as hyperthyroidism and is caused by thyrotropin receptor antibodies (trabs) that stimulate thyroid-stimulating hormone receptors. we previously reported that graves' disease patients and healthy controls both had epstein-barr virus (ebv)-infected trab-positive b cells and the ebv-reactivated induction of these b cells in cultures may induce the production of trabs. in the present study, we quantified serum trab-igg and trab-i ... | 2016 | 27529807 |
| subtype distribution and long-term titer fluctuation patterns of serum anti-epstein-barr virus antibodies in a non-nasopharyngeal carcinoma population from an endemic area in south china: a cohort study. | serum immunoglobulin a antibodies against epstein-barr virus (ebv), viral capsid antigen (vca-iga) and early antigen (ea-iga), are used to screen for nasopharyngeal carcinoma (npc) in endemic areas. however, their routine use has been questioned because of a lack of specificity. this study aimed to determine the distributions of different subtypes of antibody and to illustrate how the natural variation patterns affect the specificity of screening in non-npc participants. | 2016 | 27527073 |
| polyclonality in sclerosing angiomatoid nodular transformation of the spleen. | sclerosing angiomatoid nodular transformation (sant) of the spleen is a morphologically distinctive lesion. although the clinical course of sant is benign, its reactive or neoplastic nature remains to be clarified. furthermore, some investigators have suggested that sant is related to igg4 sclerosing lesion or inflammatory pseudotumor with stromal cells positive for epstein-barr virus (ebv). in this study, we assessed 22 cases of sant derived from adult women. clinical data and follow-up informa ... | 2016 | 27526296 |
| viral-associated malignancies in africa: are viruses 'infectious traces' or 'dominant drivers'? | since the discovery of epstein-barr virus (ebv) the first human virus associated with cancer in 1964, the number of human malignancies associated with viruses has grown. a review of cancer incidence reveals substantial variation in the incidence of such cancers around the world. in some parts of africa, the majority of cancers are caused by infectious agents. however, there remain huge challenges in measuring the burden of cancer, especially in sub-saharan africa. despite this limitation, it is ... | 2016 | 27551983 |
| evidence of epstein-barr virus association with head and neck cancers: a review. | epstein-barr virus (ebv) is ubiquitous: over 90% of the adult population is infected with this virus. ebv is capable of infecting both b lymphocytes and epithelial cells throughout the body including the head and neck region. transmission occurs mainly by exchange of saliva. the infection is asymptomatic or mild in children but, in adolescents and young adults, it causes infectious mononucleosis, a self-limiting disease characterized by lethargy, sore throat, fever and lymphadenopathy. once esta ... | 2016 | 27548665 |
| ebv nuclear antigen 3c mediates regulation of e2f6 to inhibit e2f1 transcription and promote cell proliferation. | epstein-barr virus (ebv) is considered a ubiquitous herpesvirus with the ability to cause latent infection in humans worldwide. ebv-association is evidently linked to different types of human malignancies, mainly of epithelial and lymphoid origin. of interest is the ebv nuclear antigen 3c (ebna3c) which is critical for ebv-mediated immortalization. recently, ebna3c was shown to bind the e2f1 transcription regulator. the e2f transcription factors have crucial roles in various cellular functions, ... | 2016 | 27548379 |