Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| impact of aciclovir on genital and plasma hiv-1 rna in hsv-2/hiv-1 co-infected women: a randomized placebo-controlled trial in south africa. | several studies suggest that herpes simplex virus type 2 (hsv-2) may enhance hiv-1 transmission and disease progression. | 2009 | 19155993 |
| application of cumulative odds logistic model on risk factors analysis for sexually transmitted infections among female sex workers in kaiyuan city, yunnan province, china. | to investigate the epidemiology of sexually transmitted infections (sti) among female sex workers (fsw) in kaiyuan city, yunnan province, china, and to identify risk factors associated with sti. | 2009 | 19158150 |
| hsv suppression reduces seminal hiv-1 levels in hiv-1/hsv-2 co-infected men who have sex with men. | suppressive herpes simplex virus (hsv) therapy can decrease plasma, cervical, and rectal hiv-1 levels in hiv-1/hsv-2 co-infected persons. we evaluated the effect of hsv-2 suppression on seminal hiv-1 levels. | 2009 | 19169140 |
| [persistent painful periorificial ulcerations]. | 2009 | 19171237 | |
| a molecular method for typing herpes simplex virus isolates as an alternative to immunofluorescence methods. | typing of herpes simplex virus (hsv) isolates is required to identify the virus isolated in culture. the methods available for this include antigen detection by immunofluorescence (if) assays and polymerase chain reaction (pcr). this study was undertaken to standardize a molecular method for typing of hsv and compare it with a commercial if reagent for typing. | 2009 | 19172054 |
| [std in the eye]. | in this paper, we review sexually transmitted diseases (std) involving the eye. recently conjunctivitis due to chlamydia trachomatis in children and adults is increasing, and that of neisseria gonorrhoeae resistant to multiple antibiotics has attracted special attention in our country. syphilis has many ocular manifestations such as keratitis, iridocyclitis, retinochorioiditis, and neuritis, etc. ocular complications related to hiv infection, including hiv retinopathy, cytomegalovirus retinitis, ... | 2009 | 19177759 |
| [genital herpes]. | genital herpes (gh) is the second leading cause of sexual transmitted disease in women and the third in men. about 40% of female genital herpes is caused by herpes simplex virus type 1 (hsv-1) and the remaining by type-2 (hsv-2). fifty four percent of primary female gh was caused by type-1, whereas 86% of recurrent cases by type-2. for rapid diagnosis of gh, lamp(loop-mediated isothermal amplification), hsv dna nuclear amplification method developed in japan, was applied and favorable results we ... | 2009 | 19177764 |
| evaluation of three analyte-specific reagents for detection and typing of herpes simplex virus in cerebrospinal fluid. | the performance of three analyte-specific reagents (asrs); cepheid herpes simplex virus (hsv) typing primer probe set (cd), eragen multicode-rtx hsv-1/2 kit primer mix (er), and roche lightcycler hsv-1/2 primer/hybridization probes (rd), was evaluated for detection and typing of herpes simplex virus (hsv-1 and hsv-2) in cerebrospinal fluid (csf) specimens. of 68 csf specimens, hsv-1 was detected in 8 specimens and hsv-2 was detected in 17 specimens. er detected all 25 hsv-positive specimens, whe ... | 2009 | 19179035 |
| herpes simplex virus-2 infection in male rural migrants in shanghai, china. | the overall herpes simplex virus (hsv)-2 seroprevalence was 5.5% among male rural migrants working in construction sites, markets and factories, 5.4% among those reporting having had sexual intercourse and 5.8% among those reporting no sexual intercourse. multiple logistic regression analyses indicate that migrants having higher income were more likely to have hsv-2 infection. none of the hsv-2-positives realized their infection status. future sexually transmitted disease (std) intervention prog ... | 2009 | 19182057 |
| update on successes and challenges regarding mother-to-child transmission of hiv. | there is an unprecedented global commitment to reverse the pediatric hiv epidemic by making prevention of mother-to-child transmission (pmtct) services accessible in all countries. this review outlines the successes made and the challenges that remain. | 2009 | 19242245 |
| seroprevalences of herpes simplex virus type 2 and chlamydia trachomatis in turkey. | aim was to detect the seroprevalences of herpes simplex virus type 2 (hsv-2) and chlamydia trachomatis in a subpopulation of turkey. | 2009 | 19242702 |
| prevalence of sexually transmitted infections among pregnant women with known hiv status in northern tanzania. | to determine the prevalence of sexually transmitted infections (stis) and other reproductive tract infections (rtis) among pregnant women in moshi, tanzania and to compare the occurrence of stis/rtis among human immunodeficiency virus (hiv)-infected and uninfected women. | 2009 | 19243592 |
| entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha. | herpes simplex virus 1 (hsv-1) enters cells either via fusion of the virion envelope and host cell plasma membrane or via endocytosis, depending on the cell type. in the study reported here, we investigated a viral entry pathway dependent on the paired immunoglobulin-like type 2 receptor alpha (pilralpha), a recently identified entry coreceptor for hsv-1 that associates with viral envelope glycoprotein b (gb). experiments using inhibitors of endocytic pathways and ultrastructural analyses of chi ... | 2009 | 19244335 |
| dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-beta-d-glucopyranosyl derivatives of n(4)-benzoyl cytosine. | the synthesis of the dideoxy fluoro ketopyranonucleoside analogues, 1-(2,3-dideoxy-3-fluoro-6-o-trityl-beta-d-glycero-hexopyranosyl-4-ulose)-n(4)-benzoyl cytosine (7a), 1-(3,4-dideoxy-3-fluoro-6-o-trityl-beta-d-glycero-hexopyranosyl-2-ulose)-n(4)-benzoyl cytosine (13a) and their detritylated analogues 8a and 14a, respectively, is described. condensation of peracetylated 3-deoxy-3-fluoro-d-glucopyranose (1) with silylated n(4)-benzoyl cytosine, followed by selective deprotection and isopropyliden ... | 2009 | 19246130 |
| monitoring of herpes simplex virus in the lower respiratory tract of critically ill patients using real-time pcr: a prospective study. | herpes simplex virus (hsv) has increasingly been associated with pulmonary disease in critically ill patients. however, the clinical relevance of hsv is still a topic of debate. monitoring of hsv in a quantitative way could potentially give relevant information on its role in the pathogenesis of lower respiratory tract infection. a fast and reliable quantitative real-time pcr (q-pcr) for the quantitative detection of hsv-1 and hsv-2 dna was developed. a prospective observational study was perfor ... | 2009 | 19260875 |
| multiplex pcr testing detection of higher-than-expected rates of cervical mycoplasma, ureaplasma, and trichomonas and viral agent infections in sexually active australian women. | knowing the prevalence of potential etiologic agents of nongonococcal and nonchlamydial cervicitis is important for improving the efficacy of empirical treatments for this commonly encountered condition. we describe four multiplex pcrs (mpcrs), designated vdl05, vdl06, vdl07, and vdl09, which facilitate the detection of a wide range of agents either known to be or putatively associated with cervicitis, including cytomegalovirus (cmv), enterovirus (ev), epstein-barr virus (ebv), varicella-zoster ... | 2009 | 19261782 |
| herpes simplex virus: incidence of neonatal herpes simplex virus, maternal screening, management during pregnancy, and hiv. | neonatal herpes simplex virus infection is often severe, if not fatal. what is our understanding of the epidemiology of this disease? how is it diagnosed? would maternal screening for herpes simplex virus-2 (hsv-2) in pregnancy make a difference? does maternal hsv alter transmission of hiv vertically or horizontally or both? these questions continue to be pursued and unfortunately, there are few clear answers. | 2009 | 19262380 |
| herpes simplex virus type 2 tegument proteins contain subdominant t-cell epitopes detectable in balb/c mice after dna immunization and infection. | cytotoxic t cells are important in controlling herpes simplex virus type 2 (hsv-2) reactivation and peripheral lesion resolution. humans latently infected with hsv-2 have cytotoxic t cells directed against epitopes present in tegument proteins. studies in mice of immunity to hsv have commonly focused on immunodominant responses in hsv envelope glycoproteins. these antigens have not proved to be an effective prophylactic vaccine target for most of the human population. the murine immune response ... | 2009 | 19264627 |
| seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in japan. | there have been few population-based studies of the seroprevalence and correlates of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in japan. | 2009 | 19265271 |
| the acceptance of hsv-testing partners of hsv-2 seronegative pregnant women. | to estimate the acceptance of hsv testing partners of hsv seronegative pregnant women and identify associated factors. | 2009 | 19265731 |
| hsv-2 icp34.5 protein modulates herpes simplex virus glycoprotein processing. | the icp34.5 gene from hsv-2 strain 333 was cloned and, when expressed in vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein c (gc1), a representative viral glycoprotein, during infection with hsv-1 sp7. the icp34.5 from hsv-1 sp7 limits the extent and efficiency of viral glycoprotein processing. the ability of the hsv-2 icp34.5 protein to enhance the efficiency and extent of hsv-1 sp7 glycoprotein processing indicates that modulation of viral glycoprotein p ... | 2009 | 19267180 |
| [update on the treatment of genital herpes]. | genital herpes is a chronic infection characterized by periodic reactivation. it can produce symptomatic disease in the host although asymptomatic viral excretion can also occur. it is currently the main cause of genital ulceration and an important public health problem that has substantial clinical, psychological, and economic repercussions. this review analyzes the currently available therapeutic options and regimens, which are based mainly on systemic use of antiviral agents such as aciclovir ... | 2009 | 19268108 |
| impairment in reactivation of a latency associated transcript (lat)-deficient hsv-2 is not solely dependent on the latent viral load or the number of cd8(+) t cells infiltrating the ganglia. | the hsv latency-associated transcript (lat) is abundantly expressed during virus latency. previous studies have shown that the latent viral load and cd8(+) t cells in ganglia influence the rate of reactivation of hsv. while lat is important for efficient reactivation and establishment of latency, it is uncertain how lat affects either the hsv latent viral load or cd8(+) t cell infiltration of ganglia. we infected mice with lat-deficient or lat-restored hsv-2 at a wide range of inocula. we found ... | 2009 | 19269661 |
| fatal herpes simplex virus type 2 pneumonia in a person with aids. | 2009 | 19271329 | |
| impervious. | 2009 | 19272483 | |
| evaluation of chikusetsusaponin iva isolated from alternanthera philoxeroides for its potency against viral replication. | chikusetsusaponin iva and calenduloside e were isolated from the whole plant of alternanthera philoxeroides (mart.) griseb (amaranthaceae) and evaluated for their antiviral activities. chikusetsusaponin iva showed antiviral activities against hsv-1, hsv-2, human cytomegalovirus, measles virus, and mumps virus with selectivity indices (cc (50)/ic (50)) of 29, 30, 73, 25, and 25, respectively. on the other hand, calenduloside e showed no antiviral effects against any of the viruses tested. the mod ... | 2009 | 19277947 |
| [impact of low-intensity laser on the suppression of infections caused by herpes simplex viruses 1 and 2: in vitro study]. | the use of low-level laser to suppress infections caused by herpes simplex viruses 1 and 2 was evaluated after one to five applications. a gradual reduction in replication of herpes simplex viruses 1 and 2 was observed, with 68.4% and 57.3% inhibition, respectively, after five applications, thus favoring its clinical use. | 2009 | 19287943 |
| cervical human papillomavirus incidence and persistence in a cohort of hiv-negative women in zimbabwe. | persistent infections with oncogenic human papillomavirus (hpv) types are causally related to cervical cancer. little is known about the distribution of hpv types, independent risk factors of incidence and persistence, and patterns of persistence in sub-saharan africa. | 2009 | 19295468 |
| identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes. | information on sites in hsv genomes at which foreign gene(s) can be inserted without disrupting viral genes or affecting properties of the parental virus are important for basic research on hsv and development of hsv-based vectors for human therapy. the intergenic region between hsv-1 ul3 and ul4 genes has been reported to satisfy the requirements for such an insertion site. the ul3 and ul4 genes are oriented toward the intergenic region and, therefore, insertion of a foreign gene(s) into the re ... | 2009 | 19302526 |
| is education the link between orphanhood and hiv/hsv-2 risk among female adolescents in urban zimbabwe? | as the population of orphans grows in aids-affected settings, recent studies describe a heightened risk of hiv and sexual risk behaviours among adolescent orphans compared to their non-orphaned peers. this study explores the role of education in explaining the excess sexual risk previously documented among unmarried female orphans in urban zimbabwe. school attendance and attainment were assessed by type of orphanhood, and for their association with markers of sexual risk (hiv and/or hsv-2 infect ... | 2009 | 19303688 |
| predictors for casual sex and/or infection among sexually transmitted disease clinic attendees in china. | to assess the risk factors for casual sex and infections among the sexually transmitted disease (std) clinic attendees in two disparate chinese cities, an std clinic-based cross-sectional study was conducted to provide demographic and sexual behaviour information. participants were recruited from nine std clinics selected by mapping strategy. std prevalence was 69.4% (68.6% of men and 65.2% of women). the most common diagnoses were non-gonococcal urethritis (22.2%), genital warts (13.2%), syphil ... | 2009 | 19304968 |
| seroprevalence of herpes simplex virus-2 infection among women seeking medical care for signs and symptoms of vaginitis. | two identically designed studies were conducted to determine the prevalence of herpes simplex virus type 2 (hsv-2) infection and viral shedding among women with no known history of genital herpes or hsv-2 seropositivity, who sought care at a us-based obstetrics/gynaecology clinic because of recurrent signs and symptoms of vaginitis. samples comprised 50 women of any race (all-comers sample; study 1) and 49 black women (black sample; study 2) diagnosed at the clinic visit with vaginitis on the ba ... | 2009 | 19306602 |
| genital herpes education and counselling: testing a one-page 'faq' intervention. | approximately 17% of adults in the usa have antibodies to herpes simplex virus type 2 (hsv-2), 85-90% of whom are unaware of their infection. diagnosed patients are more likely to detect hsv reactivation, disclose infection status to partner(s) and employ risk-reduction strategies; therefore, diagnosing more cases may reduce herpes transmission rates. providers are reluctant to identify genital herpes because of potentially lengthy counselling visits or discomfort in dealing with patients' emoti ... | 2009 | 19306603 |
| hiv and other sexually transmitted infections among men, transgenders and women selling sex in two cities in pakistan: a cross-sectional prevalence survey. | the extent and possibilities of spread of the hiv epidemic are not fully understood in pakistan. a survey was conducted among men, women and transgender populations selling sex in rawalpindi (punjab) and abbottabad (north west frontier province) in order to inform evidence-based programme planning. | 2009 | 19307351 |
| in vitro detection of herpes simplex virus -1 and -2 infection with immunospecific gd3+-cl6-enhanced magnetic resonance imaging. | herpes simplex virus infections are prevalent viral infections in humans. hsvs are also the most common cause of sporadic viral encephalitis (hse). magnetic resonance is the imaging method of choice for hse because it provides the most sensitive method for detecting early lesions. the objective of this study is to set-up and in vitro test an experimental contrast agent specific for antigens present on hsv-infected cells, bound with a paramagnetic agent detectable by mr imaging. a selected anti-h ... | 2009 | 19309561 |
| prevalence of chlamydia trachomatis and herpes simplex virus 2 in cervical carcinoma associated with human papillomavirus detected in paraffin-sectioned samples. | the aim of the study was to evaluate the frequency of occurrence of hpv and co-infection: chlamydia (c.) trachomatis and hsv-2 in cervical cancer. | 2009 | 19317260 |
| regulation of histone deposition on the herpes simplex virus type 1 genome during lytic infection. | during lytic infection by herpes simplex virus type 1 (hsv-1), histones are present at relatively low levels on the viral genome. however, the mechanisms that account for such low levels--how histone deposition on the viral genome is blocked or how histones are removed from the genome--are not yet defined. in this study, we show that histone occupancy on the viral genome gradually increased with time when transcription of the viral immediate-early (ie) genes was inhibited either by deletion of t ... | 2009 | 19321615 |
| male circumcision for the prevention of hsv-2 and hpv infections and syphilis. | male circumcision significantly reduced the incidence of human immunodeficiency virus (hiv) infection among men in three clinical trials. we assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (hsv-2) and human papillomavirus (hpv) infections and syphilis in hiv-negative adolescent boys and men. | 2009 | 19321868 |
| prevention of viral sexually transmitted infections--foreskin at the forefront. | 2009 | 19321872 | |
| synthesis, antiviral and anticancer activity of some novel thioureas derived from n-(4-nitro-2-phenoxyphenyl)-methanesulfonamide. | due to a continuing effort to develop new antiviral agents, a series of 1-[4-(methanesulfonamido)-3-phenoxyphenyl]-3-alkyl/aryl thioureas 3a-i have been synthesized by the reaction of alkyl/aryl isothiocyanates with 4-amino-2-phenoxymethanesulfonanilide. these derivatives were structurally characterized by the use of spectral techniques and evaluated for their anticancer and antiviral activities. none of the tested compounds showed significant anticancer properties on a549 and l929 cell lines. a ... | 2009 | 19324473 |
| herpesviruses in chronic and aggressive periodontitis patients in an indian population. | many recent studies have assessed the prevalence and role of herpesviruses in the etiopathogenesis of periodontal diseases, which has led to the realization of intricate interactions between viruses and bacteria within periodontal pockets. it has also been shown that the occurrence of herpesviruses may vary depending upon the age of the patient and the race of the population studied. thus, the present study aimed at detecting herpes simplex virus type 1 and 2 (hsv 1 and 2), epstein-barr virus (e ... | 2009 | 19325203 |
| child sexual abuse and persistence of risky sexual behaviors and negative sexual outcomes over adulthood: findings from a birth cohort. | to determine the impact of child sexual abuse (csa) on adult sexual behaviors and outcomes over three age periods. | 2009 | 19327837 |
| herpes simplex virus type 2 (mollaret's) meningitis: a case report. | mollaret's meningitis is an unusual and under-appreciated syndrome of benign, recurrent aseptic meningitis. the available literature indicates that the causative agent is herpes simplex virus type 2 (hsv-2) in the majority of cases and much less frequently herpes simplex virus type 1 (hsv-1). | 2009 | 19329344 |
| prospective study of correlates of vaginal lactobacillus colonisation among high-risk hiv-1 seronegative women. | vaginal colonisation with lactobacillus species is characteristic of normal vaginal ecology. the absence of vaginal lactobacilli, particularly hydrogen peroxide (h(2)o(2))-producing isolates, has been associated with symptomatic bacterial vaginosis (bv) and increased risk for hiv-1 acquisition. identification of factors associated with vaginal lactobacillus colonisation may suggest interventions to improve vaginal health. | 2009 | 19329442 |
| seroprevalence of kaposi sarcoma-associated herpesvirus and other serologic markers in the brazilian amazon. | to determine the presence of kaposi sarcoma-associated herpesvirus (kshv) and other serologic markers, we tested serum specimens of 339 amerindians, 181 rural non-amerindians, and 1,133 urban blood donors (13 amerindians) in the brazilian amazon. high kshv seroprevalence in children and inverse association with herpes simplex virus type 2 indicates predominant nonsexual transmission among amerindians. | 2009 | 19331768 |
| sexually transmitted diseases diagnosed among travelers returning from the tropics. | data are lacking on the spectrum of sexually transmitted diseases (stds) diagnosed in returning travelers. | 2009 | 19335805 |
| seroprevalence and factors associated with herpes simplex virus type 2 among hiv-negative high-risk men who have sex with men from rio de janeiro, brazil: a cross-sectional study. | herpes simplex virus type 2 (hsv-2) is the leading cause of genital ulcer disease in developing countries, including brazil, and is especially prevalent among men who have sex with men (msm). hsv-2 infection represents a risk factor for the acquisition and transmission of other sexually transmitted diseases. the goal of the present cross-sectional study was to estimate hsv-2 seroprevalence and to determine the factors associated with hsv-2 seropositivity in hiv-negative high-risk msm from rio de ... | 2009 | 19335922 |
| herpes simplex. | after completing this article, readers should be able to: 1. characterize the epidemiology of herpes simplex virus (hsv) infection, including mode of transmission, incubation period, and period of communicability. 2. recognize the difference in clinical manifestations of hsv1 and hsv2 infection. 3. diagnose various manifestations of hsv infection. 4. describe the difference in the clinical manifestations and outcome of hsv infection in newborns and older infants and children. 5. discuss the mana ... | 2009 | 19339385 |
| unusually high hiv infectiousness in an hiv-, hcv- and hsv-2-coinfected heterosexual man. | we report an hiv-hcv-hsv-2-coinfected man, who infected all of five sequential female sexual partners within seven years. hiv-rna in semen was unusually high and exceeded that in plasma by one log10. screening for sexually transmitted diseases remained negative with the exception of hsv-2-seropositivity. recurrent asymptomatic genital herpes might explain the patient's increased hiv-rna shedding in semen. | 2009 | 19350427 |
| simultaneous identification of 14 genital microorganisms in urine by use of a multiplex pcr-based reverse line blot assay. | the aim of this study was to develop and evaluate a sensitive method for the simultaneous identification of 14 urogenital potential pathogens. a multiplex pcr-based reverse line blot (mpcr/rlb) assay was developed to detect 14 urogenital pathogens or putative pathogens, namely trichomonas vaginalis, streptococcus pneumoniae, neisseria gonorrhoeae, chlamydia trachomatis, ureaplasma parvum, u. urealyticum, gardnerella vaginalis, haemophilus influenzae, herpes simplex virus type 1 (hsv1) and hsv2, ... | 2009 | 19357202 |
| prevention of genital herpes simplex virus type 1 and 2 disease in mice immunized with a gd-expressing dominant-negative recombinant hsv-1. | cj9-gd is a novel herpes simplex virus (hsv) type 1 recombinant virus that is completely replication-defective, expresses high-levels of hsv-1 major antigen glycoprotein d (gd), and can function in trans to inhibit replication of wild-type hsv-1 and hsv-2 in co-infected cells. here, we show that immunization with cj9-gd elicits strong and long-lasting humoral and th1-like cellular immune responses against both hsv-1 and hsv-2. mice immunized with cj9-gd exhibited significant reductions in the ex ... | 2009 | 19357711 |
| [the influence of chronic viral infections on tuberculosis]. | the influence of chronic viral infections (cvi) on tuberculosis (tb) was investigated in 117 patients with mix infection (hhv-2 - human herpes virus-2) and tb; 6 patients with mix infection (cmv - cytomegalovirus) and tb; 22 patients with mix infection (individuals with chronic hepatitis c virus (hcv) infection and tb. the control group was composed of 33 tb patients without cvi. increased rates of atypical tuberculosis, reactivation of latent tuberculosis have been reported among patients with ... | 2009 | 19359724 |
| estimating the public health impact of the effect of herpes simplex virus suppressive therapy on plasma hiv-1 viral load. | trials of herpes simplex virus (hsv) suppressive therapy among hsv-2/hiv-1-infected individuals have reported an impact on plasma hiv-1 viral loads (pvls). our aim was to estimate the population-level impact of suppressive therapy on female-to-male hiv-1 sexual transmission. | 2009 | 19367154 |
| circumcision's place in the vicious cycle involving herpes simplex virus type 2 and hiv. | 2009 | 19367793 | |
| comparative performance of a novel herpes simplex virus type 2-specific enzyme-linked immunosorbent assay using a targeted chain oligopeptide, peptide 55. | herpes simplex virus (hsv) glycoprotein g (gg2) has been used as the basis of many serological assays for the detection of hsv type 2 (hsv-2)-specific antibodies. in the present study, an enzyme-linked immunosorbent assay (elisa), the pathozyme viro hsv-2 immunoglobulin g (igg) elisa (omega diagnostics, alva, united kingdom), based on an immunodominant epitope of gg2 presented in a branched-chain format (peptide 55), was compared with two commercially available gg2-specific assays, the bioelisa ... | 2009 | 19369475 |
| multiple viral genome search in endolabyrinthic fluids of profoundly deaf patients: possible cytomegalovirus intracochlear reactivation. | the cause of about 30% of bilateral sensorineural hearing loss (snhl) is still unknown. a viral etiology is among the most frequently proposed ones and the supposed diagnosis is only based upon few clinical and laboratory data. the detection of viral presence within a damaged compartment may represent a way to supply interesting data for confirmation of viral etiology and to explain pathogenic mechanisms. | 2009 | 19372646 |
| high hiv and ulcerative sexually transmitted infection incidence estimates among men who have sex with men in peru: awaiting for an effective preventive intervention. | in the andean region, hiv and sexually transmitted infections (sti) are most prevalent among men who have sex with men (msm), but incidence estimates and associated factors have never been prospectively assessed. | 2009 | 19384102 |
| pediatric herpes simplex virus keratitis. | to report the clinical characteristics and visual outcomes of pediatric herpes simplex virus (hsv) keratitis. | 2009 | 19387223 |
| meta-analytical studies on the epidemiology, prevention, and treatment of human immunodeficiency virus infection. | since the beginning of the epidemic, extensive research has been conducted in the field of hiv infection. original research and subsequent meta-analyses have contributed to a better understanding of the disease. epidemiologic research has shown, for example, that male circumcision reduces the risk of female-to-male transmission. nevertheless, the question whether circumcision confers protection against hiv transmission in msm remains open. studies have shown a positive correlation between hiv an ... | 2009 | 19393910 |
| characteristics of hiv-1 discordant couples enrolled in a trial of hsv-2 suppression to reduce hiv-1 transmission: the partners study. | the partners hsv-2/hiv-1 transmission study (partners study) is a phase iii, placebo-controlled trial of daily acyclovir for genital herpes (hsv-2) suppression among hiv-1/hsv-2 co-infected persons to reduce hiv-1 transmission to their hiv-1 susceptible partners, which requires recruitment of hiv-1 serodiscordant heterosexual couples. we describe the baseline characteristics of this cohort. | 2009 | 19404392 |
| does psychosocial stress predict symptomatic herpes simplex virus recurrence? a meta-analytic investigation on prospective studies. | previous psychological studies have paid extensive attention to the association between psychosocial stress and symptomatic herpes simplex virus (hsv) recurrence, but subsequent research has been conducted and conflicting findings have been published. we aimed to quantify the longitudinal association between psychosocial stress and recurrent hsv in the contemporary literature. we searched medline; psycinfo; web of science; pubmed up to march 2009, and included prospective studies that investigat ... | 2009 | 19409481 |
| phosphonate analogues of cyclopropavir phosphates and their e-isomers. synthesis and antiviral activity. | z- and e-phosphonate analogues 12 and 13 derived from cyclopropavir and the corresponding cyclic phosphonates 14 and 15 were synthesized and their antiviral activity was investigated. the 2,2-bis(hydroxymethylmethylenecyclopropane acetate (17) was transformed to tetrahydropyranyl acetate 18. deacetylation gave intermediate 19 which was converted to bromide 20. alkylation with diisopropyl methylphosphonate afforded after protecting group exchange (21 to 22) acetylated phosphonate intermediate 22. ... | 2009 | 19410465 |
| polymorphisms of mtdna control region in tunisian and moroccan populations: an enrichment of forensic mtdna databases with northern africa data. | current forensic mitochondrial (mt)dna databases are limited in representative population data of african origin. we investigated hvs-i/hvs-ii sequences of 120 tunisian and moroccan healthy male donors applying stringent quality criteria to assure high quality of the data and phylogenetic alignment and notation of the sequences. among 64 tunisians, 56 different haplotypes were observed and the most common haplotype (16187t 16189c 16223t 16264t 16270t 16278t 16293g 16311c 73g 152c 182t 185t 195c ... | 2009 | 19414164 |
| isolation of sulfated galactan from codium fragile and its antiviral effect. | a sulfated galactan (fg) was isolated from the green alga, codium fragile. chemical analysis revealed that fg mainly consisted of d-galactose with pyruvic acid (12.3%) and sulfate (11.0%). methylation and nmr analyses showed that fg was composed of -->3)-beta-d-galp-(1-->, beta-d-galp-(1--> and -->3,6)-beta-d-galp-(1--> residue. in addition, pyruvic acid was suggested to be present as (1'-carboxy)-ethylidene cyclic ketal at o-3 and o-4 of non-reducing terminal galactose residues, whereas sulfate ... | 2009 | 19420760 |
| in vitro anti-herpetic activity of an aqueous extract from the plant phyllanthus orbicularis. | the herpesviridae includes at least eight viral species pathogenic for humans, responsible for a wide variety of clinical symptoms. the lack of an effective vaccine and the moderate to high toxicity of the available synthetic anti-herpes compounds emphasises the need for new inhibitors. several phyllanthus genus (euphorbiaceae) members have been widely used in traditional medicine and their biological properties have been intensely studied. in this study we investigated the in vitro antiviral ac ... | 2009 | 19423312 |
| the herpes simplex virus-induced demise of keratinocytes is associated with a dysregulated pattern of p63 expression. | p63 plays a pivotal role in the development and maintenance of stratified epithelial tissues. in an effort to gain insight into the pathogenic mechanisms of skin infections caused by hsv-1 and hsv-2, we determined the patterns of p63 expression in primary keratinocytes and in the hacat cell line. the levels of deltanp63alpha and a 50kda p73 isoform were decreased, bax-alpha remained unaffected, while the expressions of the bax-beta, tap63gamma and a 44.5kda p73 isoform were highly increased in b ... | 2009 | 19427396 |
| an exopolysaccharide produced by geobacillus thermodenitrificans strain b3-72: antiviral activity on immunocompetent cells. | the immunomodulatory and antiviral effects of an extracellular polysaccharide (eps-2), produced by a strain of geobacillus thermodenitrificans isolated from a shallow marine vent of vulcano island (italy), were evaluated. in the present study, we show for the first time that eps-2 treatment hinder hsv-2 replication in human peripheral blood mononuclear cells (pbmc) but not in wish cells. in fact, high levels of ifn-alpha, il-12, ifn-gamma, tnf-alpha, il-18 were detected in supernatants of eps-2 ... | 2009 | 19428560 |
| analysis of varicella-zoster virus and herpes simplex virus in various clinical samples by the use of different pcr assays. | rapid and reliable detection of varicella-zoster virus (vzv) and herpes simplex virus type 1 (hsv-1) and -2 (hsv-2) is of clinical significance in immunocompromised patients and patients with infections of the central nervous system. this paper describes the detection of vzv and hsv using the commercially available affigene vzv and affigene hsv 1/2 tracer kits in comparison to "in-house" polymerase chain reaction (pcr) assays. for sample preparation, qiagen (hilden, germany) and affigene (cephei ... | 2009 | 19433110 |
| disentangling contributions of reproductive tract infections to hiv acquisition in african women. | : to estimate the effects of reproductive tract infections (rtis) on hiv acquisition among zimbabwean and ugandan women. | 2009 | 19434010 |
| therapeutic effect of meliacine, an antiviral derived from melia azedarach l., in mice genital herpetic infection. | since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of melia azedarach l., a plant used in traditional medicine in india for the treatment of several diseases, has been studied. meliacine exhibits a potent antiviral effect against several viruses without displaying cytotoxicity. the purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of ... | 2009 | 19441066 |
| [benign recurrent lymphocytic meningitis from herpes simplex virus type 2]. | 2009 | 19445858 | |
| [culture of hsv-2 and cloning of specific fragment of the gg-2 gene]. | to clone the glycoprotein g gene and its specific fragment with high conservation and antigenicity by culturing and amplifying herpes simplex virus type 2 and extracting its whole genome. | 2009 | 19452693 |
| seroprevalence of sexually transmitted viruses in the tribal population of central india. | to determine the seroprevalence of human immunodeficiency virus (hiv), hepatitis b and c viruses (hbv, hcv), and herpes simplex virus type 2 (hsv-2) in the tribal population of central india. | 2009 | 18573674 |
| prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters. | to determine the prevalence of herpes viruses in the semen of an asymptomatic male cohort with and without infertility problems and its association with altered semen parameters. | 2009 | 18565516 |
| comparison of intramuscular and footpad subcutaneous immunization with dna vaccine encoding hsv-gd2 in mice. | herpes simplex virus type 2 is the most common infectious agent in humans that causes genital herpes disease and vaccination is a desirable method to prevent herpes infections. an effective therapeutic vaccine will need to elicit virus-specific immune responses. the route of immunization has important role in immune responses. in this study, dna vaccine encoding glycoprotein d of herpes simplex virus type 2 (hsv-gd2) was prepared and injected via intramuscular and footpad routes to determine the ... | 2009 | 18571235 |
| does douching increase risk for sexually transmitted infections? a prospective study in high-risk adolescents. | the objective of the study was to examine the association between douching and 4 sexually transmitted infections (stis). | 2009 | 18667177 |
| prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection. | oral reactivation of latent herpes simplex virus (hsv) infection may easily occur in cancer patients. virus reactivation can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect of cancer therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. | 2009 | 18713235 |
| prevalence and predictors of hiv infection among female sex workers in kaiyuan city, yunnan province, china. | sexual transmission is the fastest growing route of hiv transmission in china. we undertook this study to describe the risk factors for hiv infection in female sex workers (fsws), and to determine the commercial sex venues where fsws are most at risk of being infected with or infecting others with hiv. | 2009 | 18718801 |
| prevalence of sexually transmitted infections among men who have sex with men in zagreb, croatia. | we used respondent-driven sampling among men who have sex with men (msm) in zagreb, croatia in 2006 to investigate the prevalence of hiv, other sexually transmitted infections and sexual behaviours. we recruited 360 msm. hiv infection was diagnosed in 4.5%. the seroprevalence of antibodies to viral pathogens was: herpes simplex virus type-2, 9.4%; hepatitis a, 14.2%; hepatitis c, 3.0%. eighty percent of participants were susceptible to hbv infection (hbs antigen negative, and no antibodies to hb ... | 2009 | 18690533 |
| the burden and determinants of hiv and sexually transmitted infections in a population-based sample of female sex workers in goa, india. | interventions targeting sex workers are central to the national aids control programme of india's third 5-year plan. understanding the way in which societal and individual factors interact to shape sex workers' vulnerability would better inform interventions. | 2009 | 18684856 |
| [diagnosis of herpetic esophagitis in the immunocompetent subject by pcr (herpès consensus générique-argène). report of six cases]. | we have researched and identified herpes viruses on the esophageal biopsies taken during the period between september 2006 and march 2008 for 15 suspected patients. | 2009 | 18842356 |
| structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design. | a series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (acv) were evaluated for their chemical stability, cytotoxicity, and antiviral activity against several strains of herpes simplex-1 and -2, vaccinia, vesicular stomatitis, cytomegalovirus and varicella zoster viruses. acv dipeptide esters were very active against herpetic viruses, independently of the rate at which they liberate the parent drug. their minimum cytotoxic concentrations were above 100 microm and the resul ... | 2009 | 18848738 |
| synthesis, antioxidative and antiviral activity of hydroxycinnamic acid amides of thiazole containing amino acid. | the synthesis and the biological (antioxidant and antiviral) activities of novel hydroxycinnamic acid amides of a thiazole containing tfa.valine-4-carboxylic acid ethyl ester are reported. the amides have been synthesized from p-coumaric, ferulic and sinapic acids with the corresponding tfa.valine-thiazole-4-carboxylic acid ethyl ester using the coupling reagent n-ethyl-n'-(3-dimethylaminopropyl) carbodiimide hydrochloride (edc) and 4-(dimethylamino) pyridine (dmap) as a catalyst. the antioxidan ... | 2009 | 18853101 |
| correlates of incarceration among young methamphetamine users in chiang mai, thailand. | we examined correlates of incarceration among young methamphetamine users in chiang mai, thailand in 2005 to 2006. | 2009 | 18923109 |
| spectroscopic detection and identification of infected cells with herpes viruses. | matrix-assisted laser desorption/ionization time-of-flight (maldi-tof) and fourier transform infrared (ftir) microspectroscopy were previously applied for the identification of various biological samples. in the present study, normal cells in culture and cells infected with herpes simplex virus type 2 (hsv-2) or varicella-zoster virus (vzv) were analyzed by maldi-tof and ftir microscopy. specific spectral biomarkers for rapid and reliable monitoring and identification of infected cells and proba ... | 2009 | 18932269 |
| a gateway recombination herpesvirus cloning system with negative selection that produces vectorless progeny. | crossover recombination based on the lambda phage integration/excision functions enables insertion of a gene of interest into a specific locus by a simple one-step in vitro recombination reaction. recently, a highly efficient recombination system for targeted mutagenesis, which utilizes lambda phage crossover recombination cloning, has been described for a human herpesvirus 2 bacterial artificial chromosome (bac). the disadvantages of the system are that it allows only neutral selection (loss of ... | 2009 | 18948138 |
| overexpression of interleukin-15 compromises cd4-dependent adaptive immune responses against herpes simplex virus 2. | interleukin-15 (il-15) is necessary for the development and function of nk/nkt cells and the maintenance of naive and memory cd8(+) t cells. in the absence of il-15, protective innate immunity is not available; however, a functional adaptive immune response against vaginal herpes simplex virus 2 (hsv-2) is generated. mice overexpressing il-15 (il-15tg mice) have higher numbers of nk cells, greater nk-derived gamma interferon, and more cd8(+) t cells. here we examined the consequences of il-15 ov ... | 2009 | 19004955 |
| high-level expression of glycoprotein d by a dominant-negative hsv-1 virus augments its efficacy as a vaccine against hsv-1 infection. | using the t-rex (invitrogen, carlsbad, ca) gene switch technology, we previously generated a dominant-negative herpes simplex virus (hsv)-1 recombinant, cj83193, capable of inhibiting its own replication as well as that of wild-type hsv-1 and hsv-2. it has been further demonstrated that cj83193 is an effective vaccine against hsv-1 infection in a mouse ocular model. to ensure its safety and augment its efficacy, we generated an improved cj83193-like hsv-1 recombinant, cj9-gd, which contains a de ... | 2009 | 19005489 |
| differential induction of innate anti-viral responses by tlr ligands against herpes simplex virus, type 2, infection in primary genital epithelium of women. | genital epithelial cells (gecs) are the first line of mucosal defense against sexually transmitted infections. we exploited the ability of gecs to mount innate immune responses, by using tlr ligands to induce anti-viral activity against herpes simplex virus, type 2 (hsv-2). primary cultures of gecs were grown to confluent, polarized monolayers and found to express different levels of mrna for tlr1-10. innate anti-viral responses against hsv-2 infection were determined following treatment with ei ... | 2009 | 19013198 |
| novel less-abundant viral micrornas encoded by herpes simplex virus 2 latency-associated transcript and their roles in regulating icp34.5 and icp0 mrnas. | we recently identified an acutely and latently expressed viral microrna (mirna), mir-i, encoded by herpes simplex virus 2 (hsv-2) latency-associated transcript (lat) through small rna cloning and two mirnas encoded by hsv-1 lat through prediction. we now report the use of high-throughput sequencing technology to identify two additional relatively less-abundant viral mirnas, mir-ii and mir-iii, encoded by hsv-2 lat exon 2. mir-ii includes two mirnas, mir-ii-5p and mir-ii-3p, which are processed f ... | 2009 | 19019961 |
| comparison of a multiplexed herpes simplex virus type-specific immunoglobulin g serology assay to immunoblot, western blot, and enzyme-linked immunosorbent assays. | the human herpes simplex virus (hsv) is highly pathogenic, with infections caused by two distinct antigenic types, hsv-1 and hsv-2. differentiation of antibodies to these specific antigens can provide useful information for the diagnosis of subclinical or undiagnosed hsv-2 infections, as well as for reducing the risk of maternal transfer of hsv to the neonate. in this study, a multiplex assay capable of concurrent detection of hsv-1 and -2 immunoglobulin g (igg) antibodies was compared to immuno ... | 2009 | 19020107 |
| herpes simplex virus type 2 antibody detection performance in kisumu, kenya, using the herpeselect elisa, kalon elisa, western blot and inhibition testing. | in certain parts of africa, type-specific herpes simplex virus type 2 (hsv-2) elisas may have limited specificity. to date, no study has been conducted to validate herpeselect and kalon type-specific hsv-2 elisas using both the western blot and recombinant gg elisa inhibition testing as reference standards. | 2009 | 18955387 |
| virus-encoded b7-2 costimulation molecules enhance the protective capacity of a replication-defective herpes simplex virus type 2 vaccine in immunocompetent mice. | herpes simplex virus 2 (hsv-2) and, to a lesser extent, hsv-1 cause the majority of sexually transmitted genital ulcerative disease. no effective prophylactic vaccine is currently available. replication-defective hsv stimulates immune responses in animals but produces no progeny virus, making it potentially useful as a safe form of live vaccine against hsv. because it does not replicate and spread in the host, however, replication-defective virus may have relatively limited capacity to solicit p ... | 2009 | 18987142 |
| persistent and recurring viral infections: the human herpesviruses. | 2009 | 19038775 | |
| evaluation of multiplex real-time pcr for detection of haemophilus ducreyi, treponema pallidum, herpes simplex virus type 1 and 2 in the diagnosis of genital ulcer disease in the rakai district, uganda. | to develop a real-time pcr assay that reliably and accurately detects the predominant sexually transmitted aetiological agents of genital ulcer disease (gud) (haemophilus ducreyi, treponema pallidum and herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2)) and to assess the use of real-time pcr diagnostic testing in a rural african field site. | 2009 | 19066198 |
| population-level effect of potential hsv2 prophylactic vaccines on hiv incidence in sub-saharan africa. | herpes simplex virus type-2 (hsv2) infection increases hiv transmission. we explore the impact of a potential prophylactic hsv2 vaccination on hiv incidence in africa using stdsim an individual-based model. a campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to hsv2 acquisition and hsv2 reactivation by 75% for 10 years, reduced hiv incidence by 30-40% after 20 years (range 4-66%). over 20 years, in most scenarios fewer than 100 vaccinations were required ... | 2009 | 19071187 |
| is smoking an independent risk factor for invasive cervical cancer? a nested case-control study within nordic biobanks. | the strong correlation between smoking and exposure to oncogenic human papillomaviruses (hpvs) has made it difficult to verify the independent role of smoking in cervical carcinogenesis. thus, the authors evaluated this role. five large nordic serum banks containing samples from more than 1,000,000 subjects were linked with nationwide cancer registries (1973-2003). serum samples were retrieved from 588 women who developed invasive cervical cancer and 2,861 matched controls. the samples were anal ... | 2009 | 19074773 |
| population-based prevalence of antibodies against herpes simplex virus type 2 and socio-demographic characteristics in mexico. | although several studies to evaluate the correlates between seroprevalence of herpes simplex virus type 2 (hsv-2) and sexual practices have been carried out with specific groups in mexico, none has evaluated overall seroprevalence among the general population or its relationship with socio-demographic characteristics. the national health survey performed during 2000 in mexico studied a multi-stage, stratified, cluster sample of the general population. characteristics of the adult population, suc ... | 2009 | 19084884 |
| febrile ulceronecrotic mucha-habermann disease associated with herpes simplex virus type 2. | febrile ulceronecrotic mucha-habermann disease is a rare severe variant of pityriasis lichenoides et varioliformis acuta, a disease within the pityriasis lichenoides spectrum of disorders. it remains uncertain whether these disorders are preneoplastic or reactive against infectious or other antigenic stimuli. febrile ulceronecrotic mucha-habermann disease varies in severity and may be accompanied by a range of systemic symptoms. we present a case associated with herpes simplex virus infection. i ... | 2009 | 19103367 |
| hsv-1 genital infection rare in men over the age of 35 years. | 2009 | 19103904 |