Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| treatment of helicobacter pylori infection: where are we now? | gastric cancer and helicobacter pylori infection remain a burden in many asian countries. in the face of rising antibiotic resistance, the eradication rate of standard triple therapy is declining in many asian countries. we reviewed the updated epidemiology of gastric cancer, prevalence of h. pylori infection, and antibiotic resistance in asia. we also reviewed the strategies to improve the efficacy of h. pylori eradication therapies, including the use of high dose proton pump inhibitor, four dr ... | 2016 | 27088632 |
| vaca genotype status of helicobacter pylori isolated from foods with animal origin. | according to controversial theories and results of studies, foods with animal origins play an important role in the transmission of h. pylori to human. the aim of this study was to determine the distribution of vaca genotypes of h. pylori, isolated from milk and meat samples of cow, sheep, goat, camel, and buffalo. eight hundred and twenty raw milk and meat samples were collected from various parts of iran. samples were cultured and those found positive for h. pylori were analyzed for the presen ... | 2016 | 27088092 |
| biomarkers and diagnostic tools for detection of helicobacter pylori. | helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. h. pylori is associated with significant morbidity and mortality including gastric cancer. the infection has both direct and indirect impacts on economic and overall well-being of patients; hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits. here, we briefly review general aspects of h. pylori infe ... | 2016 | 27084783 |
| bet inhibition attenuates helicobacter pylori-induced inflammatory response by suppressing inflammatory gene transcription and enhancer activation. | helicobacter pylori infection causes chronic gastritis and peptic ulceration. h. pylori-initiated chronic gastritis is characterized by enhanced expression of many nf-κb-regulated inflammatory cytokines. brd4 has emerged as an important nf-κb regulator and regulates the expression of many nf-κb-dependent inflammatory genes. in this study, we demonstrated that brd4 was not only actively involved in h. pylori-induced inflammatory gene mrna transcription but also h. pylori-induced inflammatory gene ... | 2016 | 27084101 |
| serum pepsinogen levels can quantify the risk of development of metachronous gastric cancer after endoscopic resection. | we have previously reported that serum pepsinogen (pg) can quantify the level of gastric mucosal atrophy, and that h. pylori eradication reduces cancer development in subjects with mild atrophy identified by serum pg levels. the aim of this study was to elucidate the predictive ability of serum pg levels for the development of metachronous gastric cancer (mgc) after endoscopic resection (er) of primary cancer in association with h. pylori eradication. a retrospective chart review was performed, ... | 2016 | 27083518 |
| local immune response in helicobacter pylori infection. | there have been few studies concerning the cytokine profiles in gastric mucosa of helicobacter pylori-infected patients with normal mucosa, chronic gastritis, and gastric carcinoma (gac).in the present study, we aimed to elucidate the genomic expression levels and immune pathological roles of cytokines-interferon (ifn)-γ, tumor necrosis factor (tnf)-α, interleukin (il)-4, il-6, il-10, transforming growth factor (tgf)-β, il-17a, il-32-in h pylori-infected patients with normal gastric mucosa (ngm; ... | 2016 | 27196487 |
| familial clustering of gastric cancer: a retrospective study based on the number of first-degree relatives. | this comprehensive cross-sectional study aimed to identify factors contributing to familial aggregation of gastric cancer (gc). a total of 1058 gc patients and 1268 controls were analyzed separately according to the presence or absence of a first-degree relative of gc (gc-relative). logistic regression analysis adjusted for age, gender, residence during childhood, smoking, alcohol intake, monthly income, spicy food ingestion, helicobacter pylori status and host cytokine polymorphisms was perform ... | 2016 | 27196462 |
| effect of helicobacter pylori eradication and abo genotype on gastric cancer development. | evidence is lacking regarding how helicobacter pylori infection status, eradication history, and abo blood type affect the development of gastric cancer (gc) given the multifactorial and distinctive etiology according to cancer location (noncardia vs cardia) and histologic type (intestinal vs diffuse-type). we evaluated the effect of h. pylori infection status incorporated with h. pylori eradication history and abo genotype on gc development according to cancer location and histologic type. | 2016 | 27191536 |
| targeting the motion of shikimate kinase: development of competitive inhibitors that stabilize an inactive open conformation of the enzyme. | the large conformational changes observed by molecular dynamics simulation studies on the product release in the lid and shikimic acid binding (sb) domains of the shikimate kinase (sk) enzyme have been exploited in the development of reversible competitive inhibitors against sk from mycobacterium tuberculosis and helicobacter pylori. this enzyme is a recognized target for antibiotic drug discovery. the reported c5-substituted shikimic acid analogues interact with the dynamic apolar pocket that s ... | 2016 | 27191386 |
| a novel automatic rapid diagnostic test reader platform. | a novel automatic rapid diagnostic test (rdt) reader platform is designed to analyze and diagnose target disease by using existing consumer cameras of a laptop-computer or a tablet. the rdt reader is useable with numerous lateral immunochromatographic assays and similar biomedical tests. the system has two different components, which are 3d-printed, low-cost, tiny, and compact stand and a decision program named rdt-autoreader 2.0. the program takes the image of rdt, crops the region of interest ... | 2016 | 27190549 |
| genetic evolution of a helicobacter pylori acid-sensing histidine kinase and gastric disease. | helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. we sequentially isolated h. pylori (strain j99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. archival j99 survived significantly better under acidic conditions than recent j99 strains. h. pylori arsrs encodes a 2-component system critical for stress responses; recent j99 isolates harbored 2 nonsynonymous arss mut ... | 2016 | 27190191 |
| helicobacter pylori vaca transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy. | helicobacter pylori infection is the major cause of peptic ulceration and gastric cancer, and an important virulence determinant is its vacuolating cytotoxin vaca. previously, we have described allelic variation in vaca which determines toxin activity and disease risk. here we aimed to quantify vaca mrna expression in the human stomach, define its genetic determinants and assess how well it predicts gastric pathology. | 2016 | 27189958 |
| liver-related mortality in countries of the developed world: an ecological study approach to explain the variability. | liver-related mortality varies across developed nations. | 2016 | 27189900 |
| new insights into vaca intoxication mediated through its cell surface receptors. | helicobacter pylori (h. pylori), a major cause of gastroduodenal diseases, produces vaca, a vacuolating cytotoxin associated with gastric inflammation and ulceration. the c-terminal domain of vaca plays a crucial role in receptor recognition on target cells. we have previously identified three proteins (i.e., rptpα, rptpβ, and lrp1) that serve as vaca receptors. these receptors contribute to the internalization of vaca into epithelial cells, activate signal transduction pathways, and contribute ... | 2016 | 27187473 |
| expression and function of mir-155 in diseases of the gastrointestinal tract. | micrornas (mirnas) are a type of small noncoding rna that can regulate the expression of target genes under physiological and pathophysiological conditions. mir-155 is a multifunctional mirna with inflammation-related and oncogenic roles. in particular, the dysregulation of mir-155 has been strongly implicated in helicobacter pylori-related gastric disease, inflammatory bowel disease, and colorectal cancer in addition to being involved in molecular changes of important targets and signaling path ... | 2016 | 27187359 |
| crude preparations of helicobacter pylori outer membrane vesicles induce upregulation of heme oxygenase-1 via activating akt-nrf2 and mtor-iκb kinase-nf-κb pathways in dendritic cells. | helicobacter pylori sheds outer membrane vesicles (omvs) that contain many surface elements of bacteria. dendritic cells (dcs) play a major role in directing the nature of adaptive immune responses against h. pylori, and heme oxygenase-1 (ho-1) has been implicated in regulating function of dcs. in addition, ho-1 is important for adaptive immunity and the stress response. although h. pylori-derived omvs may contribute to the pathogenesis of h. pylori infection, responses of dcs to omvs have not b ... | 2016 | 27185786 |
| gastric cancer: how can we reduce the incidence of this disease? | gastric cancer remains a prevalent disease worldwide with a poor prognosis. helicobacter pylori plays a major role in gastric carcinogenesis. h. pylori colonization leads to chronic gastritis, which predisposes to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually gastric cancer. screening, treatment, and prevention of h. pylori colonization can reduce the incidence of gastric cancer. other interventions that may yield a similar effect, although of smaller magnitude, include pr ... | 2016 | 27184043 |
| helicobacter pylori γ-glutamyltranspeptidase induces tolerogenic human dendritic cells by activation of glutamate receptors. | helicobacter pylori infection is characterized by chronic persistence of the bacterium. different virulence factors, including h. pylori γ-glutamyltranspeptidase (ggt), have been reported to induce tolerogenicity by reprogramming dendritic cells (dcs). ggt is present in all bacterial isolates, indicating an important role for ggt in the course of infection. in the current study, we have analyzed the effect of h. pylori ggt on human dcs and the subsequent adaptive immune response. we show that gl ... | 2016 | 27183641 |
| intrafamilial transmission of helicobacter pylori: genotyping of faecal samples. | after more than 20 years of research, there is a little information about the detailed routes of helicobacter pylori transmission. the aim of this study was to explore intrafamilial transmission of h. pylori in children who had indication for upper gastrointestinal endoscopy and their parents. | 2016 | 27182676 |
| helicobacter pylori infection in the era of antibiotic resistance. | 2016 | 27182214 | |
| changes in patients' symptoms and gastric emptying after helicobacter pylori treatment. | to investigate the changes in clinical symptoms and gastric emptying and their association in functional dyspepsia (fd) patients. | 2016 | 27182168 |
| correlation between helicobacter pylori-associated gastric diseases and colorectal neoplasia. | to explore the correlation between helicobacter pylori (h. pylori)-associated gastric diseases and colorectal neoplasia. | 2016 | 27182167 |
| methylation of dapk and thbs1 genes in esophageal gastric-type columnar metaplasia. | to explore methylation of dapk, thbs1, cdh-1, and p14 genes, and helicobacter pylori (h. pylori) status in individuals harboring esophageal columnar metaplasia. | 2016 | 27182166 |
| impact of helicobacter pylori eradication on refractory thrombocytopenia in patients with chronic hcv awaiting antiviral therapy. | the possibility of delaying treatment of hcv due to severe thrombocytopenia is challenging. this study aimed to detect the prevalence of active helicobacter infection as a claimed cause of thrombocytopenia in a cohort of egyptian patients with chronic active hcv awaiting combined anti-viral therapy. the study included 400 chronic hcv patients with thrombocytopenia. laboratory investigations included liver function tests, real time quantitative pcr, reticulocytic count, esr, ana, bone marrow aspi ... | 2016 | 27180243 |
| lymphotoxin β receptor signalling executes helicobacter pylori-driven gastric inflammation in a t4ss-dependent manner. | lymphotoxin β receptor (ltβr) signalling has been implicated in inflammation-associated tumour development in different tissues. we have analysed the role of ltβr and alternative nf-κb signalling in helicobacter pylori-mediated gastric inflammation and pathology. | 2016 | 27196595 |
| biochemical and structural characterization of a dna n6-adenine methyltransferase from helicobacter pylori. | dna n6-methyladenine modification plays an important role in regulating a variety of biological functions in bacteria. however, the mechanism of sequence-specific recognition in n6-methyladenine modification remains elusive. m1.hpyavi, a dna n6-adenine methyltransferase from helicobacter pylori, shows more promiscuous substrate specificity than other enzymes. here, we present the crystal structures of cofactor-free and adomet-bound structures of this enzyme, which were determined at resolutions ... | 2016 | 27259995 |
| intestinal-type gastric adenocarcinoma without helicobacter pylori infection successfully treated with endoscopic submucosal dissection. | a 67-year-old woman was admitted to our hospital for further examination and for treatment of gastric neoplasia located on the posterior wall of the antrum of the stomach, as revealed by screening esophagogastroduodenoscopy. the patient had no history of helicobacter pylori (h. pylori) eradication. her serum h. pylori antibody and urea breath test results were negative, histopathological findings revealed no h. pylori bacteria, and endoscopic findings revealed no chronic gastritis. we performed ... | 2016 | 27259702 |
| demonstration of potential link between helicobacter pylori related promoter cpg island methylation and telomere shortening in human gastric mucosa. | telomere length shortening in helicobacter pylori (h. pylori) infected gastric mucosa constitutes the earliest steps toward neoplastic transformation. in addition to this genotoxic changes, epigenetic changes such as promoter cpg island (pcgi) methylation are frequently occurred in h. pylori infected gastric mucosa. the aim of this study was to investigate a potential link between h. pylori related pcgi methylation and telomere length shortening in the human gastric mucosa. | 2016 | 27259265 |
| distinct clinic-pathological features of early differentiated-type gastric cancers after helicobacter pylori eradication. | background. gastric cancer is discovered even after successful eradication of h. pylori. we investigated clinic pathological features of early gastric cancers after h. pylori eradication. methods. 51 early gastric cancers (egcs) from 44 patients diagnosed after successful h. pylori eradication were included as eradication group. the clinic-pathological features were compared with that of 131 egcs from 120 patients who did not have a history of h. pylori eradication (control group). results. comp ... | 2016 | 27212944 |
| helicobacter pylori infection in children: should it be carefully assessed? | the prevalence of h. pylori infection, mainly acquired during childhood and may be persisting throughout life, has been found high in developing countries; this high prevalence is related to low socioeconomic status. the persistence of bacterium exposure is related to gastritis and other severe complications including peptic ulcer, lymphoma malt and gastric cancer, which are rarely present in the pediatric age due to a lower inflammatory and immunological response. virulence factors, host gastri ... | 2016 | 27212173 |
| can helicobacter pylori be eradicated with high-dose proton pump inhibitor in extensive metabolizers with the cyp2c19 genotypic polymorphism? | proton pump inhibitors (ppi) metabolism and pharmacokinetics are regulated by cytochrome p450 enzymes in the liver. cytochrome p450 2c19 (cyp2c19) polymorphism plays an import role in the metabolism of ppis. the three possible genotypes for cyp2c19 each has a distinct effect on the pharmacodynamics of ppis. homozygote extensive metabolizers (homem) are the most frequent genotype and have two wild-types (non-mutant) (*1/*1) alleles. homem is associated with increased enzyme activity, which increa ... | 2016 | 27212172 |
| ascites as the initial characteristic manifestation in a patient with primary gastric cd8-positive diffuse large b-cell lymphoma. | diffuse large b-cell lymphoma (dlbcl) is the most common lymphoid malignancy and the most common type of non-hodgkin's lymphomas, the stomach is the most common extranodal site. gastric dlbcl is often characterized by epigastric pain and vomiting. we report a case of a 78-year-old female patient with gastric diffuse large b-cell lymphoma (dlbcl) with high cd8 level which was initially manifested with ascites of unknown origin. the patient was admitted with a chief complaint of abdominal distensi ... | 2016 | 27212160 |
| dual-priming oligonucleotide-based multiplex pcr using tissue samples from the rapid urease test kit for the detection of helicobacter pylori in bleeding peptic ulcers. | in patients with peptic ulcer bleeding (pub), diagnostic tests for helicobacter pylori (h. pylori) infection have low sensitivity. the aim of our study was to investigate the diagnostic yield of dual-priming oligonucleotide-based multiplex (dpo)-pcr using tissue samples from the rapid urease test (rut, clo(®)test) kit in patients with pub. | 2016 | 27211882 |
| in a world of increasing resistance emerges a hope to eradicate helicobacter pylori: vonoprazan. | 2016 | 27210791 | |
| influence of vitamin c and e supplementation on the eradication rates of triple and quadruple eradication regimens in helicobacter pylori infection. | 2016 | 27210788 | |
| is there any association between colonic polyps and gastric intestinal metaplasia? | chronic gastritis progression is a multistep process of atrophy, intestinal metaplasia (im), and dysplasia, which may lead to invasive carcinoma. in this study, we identified an association of colonic polyps with gastric im in patients undergoing colonoscopy. | 2016 | 27210777 |
| role of protein kinase d2 phosphorylation on tyr in modulation by ghrelin of helicobacter pylori-induced up-regulation in gastric mucosal matrix metalloproteinase-9 (mmp-9) secretion. | matrix metalloproteinas-9 (mmp-9) is a glycosylated endopeptidase associated with host reaction to microbial endotoxins and also characterizes gastric mucosal inflammatory response to h. pylori infection. here, we report on the factors involved in gastric mucosal mmp-9 secretion in response to h. pylori lps, and the effect of hormone, ghrelin. we show that both the lps-elicited induction in mmp-9 secretion and also the modulatory influence of ghrelin occur at the level of mmp-9 processing betwee ... | 2016 | 27209313 |
| a recombinant dna plasmid encoding the sil-4r-nap fusion protein suppress airway inflammation in an ova-induced mouse model of asthma. | asthma is a chronic inflammatory airway disease. it was prevalently perceived that th2 cells played the crucial role in asthma pathogenesis, which has been identified as the important target for anti-asthma therapy. the soluble il-4 receptor (sil-4r), which is the decoy receptor for th2 cytokine il-4, has been reported to be effective in treating asthma in phase i/ii clinical trail. to develop more efficacious anti-asthma agent, we attempt to test whether the helicobacter pylori neutrophil-activ ... | 2016 | 27209195 |
| genome-wide dna methylation profiles altered by helicobacter pylori in gastric mucosa and blood leukocyte dna. | to investigate helicobacter pylori (h.pylori) associated genome-wide aberrant methylation patterns in gastric mucosa and blood leukocyte dna, a population-based study was conducted in linqu county. | 2016 | 27206798 |
| [helicobacter pylori gastritis: assessment of olga and olgim staging systems]. | helicobacter pylori (h pylori) gastritis presents a risk of cancer related to atrophy and intestinal metaplasia. two recent classifications olga (operative link on gastritis assessment) and olgim (operative link on gastritic intestinal metaplasia assessment) have been proposed to identify high-risk forms (stages iii and iv). the aim of this study is to evaluate the olga and olgim staging systems in h pylori gastritis. a descriptive study of 100 cases of chronic h pylori gastritis was performed. ... | 2016 | 27200133 |
| helicobacter pylori promotes angiogenesis depending on wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer. | helicobacter pylori is an important pathogenic factor in gastric carcinogenesis. angiogenesis (i.e., the growth of new blood vessels) is closely associated with the incidence and development of gastric cancer. our previous study found that cox-2 stimulates gastric cancer cells to induce expression of the angiogenic growth factor vegf through an unknown mechanism. therefore, the aim of this study was to clarify the role of angiogenesis in h. pylori-induced gastric cancer development. | 2016 | 27198692 |
| severe anemia and helicobacter pylori infection in school age children; a case reports. | iron-deficiency anemia is a widespread public health problem with major consequences for human health especially, children. however, in a fraction of patients an underlying cause is never found during routine investigation. recent studies have suggested an association between helicobacter pylori (h. pylori) infection and iron-deficiency anemia. | 2016 | 27222704 |
| gastric adenocarcinoma: the role of helicobacter pylori in pathogenesis and prevention efforts. | gastric cancer is the third most common cause of cancer deaths in the world, prompting high-risk countries like south korea and japan to establish nationwide screening programmes. helicobacter pylori is linked to the majority of gastric adenocarcinoma cases and to the vast majority of non-cardia gastric adenocarcinomas. several studies have demonstrated the effectiveness of 'test-and-treat' programmes for h. pylori infection to prevent gastric cancer in high-risk populations. while this strategy ... | 2016 | 27222587 |
| understanding the dimorphic lifestyles of human gastric pathogen helicobacter pylori using the swath-based proteomics approach. | helicobacter pylori may reside in the human stomach as two morphological forms: the culturable spiral form and the viable but non-culturable (vbnc) coccoid form. this bacterium transforms from spiral to coccoid under in vitro suboptimal conditions. however, both spiral and coccoid have demonstrated its infectivity in laboratory animals, suggesting that coccoid may potentially be involved in the transmission of h. pylori. to determine the relevance of the coccoid form in viability and infectivity ... | 2016 | 27222005 |
| improved detection of helicobacter pylori infection and premalignant gastric mucosa using conventional white light source gastroscopy. | the gold standard diagnosis of h. pylori related gastritis is evidence of bacteria on histopathological examination of gastric mucosa. our aim was to study the correlation between gastric mucosal morphology and histopathological severity of h. pylori related gastritis. | 2016 | 27221902 |
| effect of il-1 polymorphisms, cyp2c19 genotype and antibiotic resistance on helicobacter pylori eradication comparing between 10-day sequential therapy and 14-day standard triple therapy with four-times-daily-dosing of amoxicillin in thailand: a prospective randomized study. | studies of effects of il-1 polymorphisms, cyp2c19 genotype together with antibiotic resistance for h. pylori eradication are rare worldwide. the present study was designed to evaluate efficacy of 10-day sequential therapy (sqt) and 14-day standard triple therapy (stt) with four- times-daily dosing of amoxicillin for h. pylori eradication related to these important host and bacterial factors in thailand. | 2016 | 27221874 |
| diagnosis of helicobacter pylori infection. | helicobacter pylori infection plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease and gastric malignancy. a diagnosis of infection is thus an important part of a treatment strategy of many gastrointestinal tract diseases. many diagnostic tests are available but all have some limitations in different clinical situations and laboratory settings. a single gold standard cannot available, but be used for diagnosis of helicobacter pylori infection in daily clinical p ... | 2016 | 27221831 |
| anti-infective potential of citrus bergamia risso et poiteau (bergamot) derivatives: a systematic review. | infectious diseases remain among the leading causes of morbidity and mortality worldwide, mainly because of the increase of resistance to chemotherapeutic drugs. nature is the major source of anti-infective drugs and could represent a font of medicines that may help overcome antibiotic resistance. recently, the potential antimicrobial effect of certain plant extracts has attracted attention within the scientific community as alternatives to synthetic drugs. here, we present a systematic review o ... | 2016 | 27218799 |
| serological response to epstein-barr virus early antigen is associated with gastric cancer and human immunodeficiency virus infection in zambian adults: a case-control study. | gastric cancer is one of the major causes of cancer related deaths, but data from sub-saharan africa are very scanty. the cancer genome atlas (tcga) initiative confirmed epstein-barr virus (ebv) related cancer as a distinct subtype, and we set out to look for serological evidence of its role in a sub-saharan african patient group. | 2016 | 27217871 |
| serum biomarker panels for diagnosis of gastric cancer. | currently, serum biomarkers that are sufficiently sensitive and specific for early detection and risk classification of gastric adenocarcinomas are not known. in this study, ten serum markers were assessed using the luminex system and enzyme-linked immunosorbent assay for the diagnosis of gastric cancer and analysis of the relation between prognosis and metastases. | 2016 | 27217769 |
| hybrid, sequential and concomitant therapies for helicobacter pylori eradication: a systematic review and meta-analysis. | to compare hybrid therapy (ht) with traditional sequential therapy (st) and concomitant therapy (ct) for helicobacter pylori (h. pylori) eradication. | 2016 | 27217708 |
| solution nmr studies on helicobacter pylori proteins for antibiotic target discovery. | helicobacter pylori (h. pylori) is a well-known widespread pathogenic bacterium that survives in the extremely acidic conditions of the human gastric mucosa. the global prevalence of h. pylori-resistant antibiotics has become an emerging issue in the 21st century and has necessitated the development of novel antibiotic drugs. many efforts have aimed to discover antibiotic target proteins of h. pylori based on its genome of more than 1600 genes. | 2016 | 27216839 |
| in vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular helicobacter pylori. | the in vitro activity of the new artemisinin derivative artemisone as well as other molecules of the same class against helicobacter pylori and their effects when combined with standard antibiotics were evaluated. since h. pylori can be internalised into gastric epithelial cells, the effects of artemisinin, dihydroartemisinin and artemisone against intracellular h. pylori were also investigated. bacteriostatic [minimum inhibitory concentration (mic)] and bactericidal [minimum bactericidal concen ... | 2016 | 27216383 |
| the toronto helicobacter pylori consensus in context. | 2016 | 27215659 | |
| detection of helicobacter pylori by real-time pcr for 16s rrna in stools of noninfected healthy children, using elisa antigen stool test as the gold standard. | we previously detected helicobacter pylori infection by stool antigen elisa assay in 33-41% of asymptomatic chilean children between 2-3 years of age, of which 11-20% had a transient infection and 21-22% a persistent infection. a total of 88% of elisa-positive samples were also rtpcr positive, while 37/133 (33%) of elisa-negative stool samples were rtpcr positive. the significance of a elisa-negative/rtpcr-positive sample requires clarification. we aimed to determine whether rtpcr is able to det ... | 2016 | 27214853 |
| combination of helicobacter pylori antibody and serum pepsinogen as a good predictive tool of gastric cancer incidence: 20-year prospective data from the hisayama study. | there is little information regarding whether the combination of helicobacter pylori (h. pylori) antibody and serum pepsinogen (spg), which is a marker of the degree of atrophic gastritis, has a discriminatory ability for detecting incident gastric cancer. we examined this issue in a long-term prospective cohort study of a japanese population. | 2016 | 27265836 |
| inhibitory effects of rhp-nap igy against helicobacter pylori attachment to ags cell line. | helicobacter pylori is a major human pathogen related to gastric adenocarcinoma and gastroduodenal diseases. treatment of h. pylori infections is complicated by the rise of antibiotic resistance, necessitating investigation of alternative therapies. one such alternative is passive immunization by oral administration of antibacterial immunoglobulin. in the present study, chicken immunoglobulin (igy) was used for passive immunotherapy against a major virulence factor of h. pylori, namely recombina ... | 2016 | 27265677 |
| rebamipide attenuates helicobacter pylori caga-induced self-renewal capacity via modulation of β-catenin signaling axis in gastric cancer-initiating cells. | rebamipide, a mucosal-protective agent, is used clinically for treatment of gastritis and peptic ulcers induced by helicobacter pylori (h. pylori) which is associated with increased risk of gastric cancer. although rebamipide is known to inhibit the growth of gastric cancer cells, the action mechanisms of rebamipide in gastric carcinogenesis remains elusive. here, we show that rebamipide suppresses h. pylori caga-induced β-catenin and its target cancer-initiating cells (c-ic) marker gene express ... | 2016 | 27265143 |
| a multicenter prospective study of the real-time use of narrow-band imaging in the diagnosis of premalignant gastric conditions and lesions. | some studies suggest that narrow-band imaging (nbi) can be more accurate at diagnosing gastric intestinal metaplasia and dysplasia than white-light endoscopy (wle) alone. we aimed to assess the real-time diagnostic validity of high resolution endoscopy with and without nbi in the diagnosis of gastric premalignant conditions and to derive a classification for endoscopic grading of gastric intestinal metaplasia (eggim). | 2016 | 27280384 |
| auranofin and n-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria helicobacter pylori. | auranofin is an fda-approved gold-containing compound used for the treatment of rheumatoid arthritis. recent reports of antimicrobial activity against protozoa and bacteria indicate that auranofin targets the reductive enzyme thioredoxin reductase (trxr). we evaluated auranofin as well as five auranofin analogs containing n-heterocyclic carbenes (instead of the triethylphosphane present in auranofin) and five gold-carbene controls for their ability to inhibit or kill helicobacter pylori in vitro ... | 2016 | 27279627 |
| the potential role of microbes in oncogenesis with particular emphasis on oral cancer. | for over a century, non-virus microorganisms, notably bacteria have been implicated as causal agents of cancers, a relatively small number of researchers have provided evidence to support the so-called "cancer germ" hypothesis. with the exception of the link between helicobacter pylori and stomach cancer, other supposed links have been ignored. a wide range of bacteria and other non-virus microbes, including fungi, have been implicated over the years in oncogenesis, as well as the ability to ind ... | 2016 | 27279505 |
| ten-day empirical sequential or concomitant therapy is more effective than triple therapy for helicobacter pylori eradication: a multicenter, prospective study. | the resistance of helicobacter pylori to antibiotics has increased the need for new empirical, first-line treatments. however, the efficacy of sequential therapy (st) and concomitant therapy (ct) compared with triple therapy (tt) has not been adequately evaluated. | 2016 | 27257049 |
| epidemiology, clinical impacts and current clinical management of helicobacter pylori infection. | helicobacter pylori infection is a major cause of morbidity and mortality worldwide. more than 50% of the global population is estimated to be infected. differences in prevalence exist within and between countries, with higher prevalence seen among people with lower socio-economic status. most transmission of infection occurs early in life, predominantly from person to person in the family setting. h. pylori is the cause of most peptic ulcer disease, gastric cancer and gastric mucosa-associated ... | 2016 | 27256648 |
| [the changes of main upper gastrointestinal diseases and helicobacter pylori infection status in the past thirty five years]. | to study the spectrum of upper gastrointestinal diseases and infection rate of helicobacter pylori(hp)in our hospital during the past 35 years. | 2016 | 27256605 |
| potential molecular aspects of helicobacter pylori-related hyperplastic polyp development and progression. | 2016 | 27254539 | |
| identification of putative z-ring-associated proteins, involved in cell division in human pathogenic bacteria helicobacter pylori. | cell division in bacteria is initiated by ftsz, which forms a z ring at the middle of the cell, between the nucleoids. the z ring is stabilized by z ring-associated proteins (zaps), which crosslink the ftsz filaments and provide strength. the deletion of zaps leads to the elongation phenotype with an abnormal z ring. the components of cell division in helicobacter pylori are similar to other gram negative bacteria except for the absence of few components including zaps. here, we used hhsearch to ... | 2016 | 27253179 |
| pathological and clinical correlation between celiac disease and helicobacter pylori infection; a review of controversial reports. | there are overwhelming reports and descriptions about celiac associated disorders. although there is a clear genetic association between celiac disease (cd) and some gastrointestinal disorders, there are controversial reports claiming an association between cd and helicobacter pylori (h. pylori) infection. different studies indicated the possible association between lymphocytic gastritis and both cd and h. pylori infection, although this evidence is not consistently accepted. also it was shown t ... | 2016 | 27252814 |
| [breath test with locally produced 13с-urea (tbilisi, georgia) in diagnostics of helicobacter pylori infection]. | comparative assessment of results of detection of helicobacter pylori (hp) infection by breath tests with standard and locally produced 13с urea was done in 213 patients with gastric and duodenal pathology, including those who already were undergone the surgery. invasive endoscopic biopsy test including rapid urease test (rut), smear cytology and histology were also performed (tissue samples were obtained after endoscopy or surgery). rut was carried out with the help of ure-hp test kit. serologi ... | 2016 | 27249440 |
| helicobacter pylori treatment failure: the rationale for alternative antibiotics. | 2016 | 27246467 | |
| association of vac a- and cag a-specific helicobacter pylori strain infection with spontaneous preterm birth. | to better understand the correlation between helicobacter pylori (h. pylori) seropositivity and spontaneous preterm birth. | 2016 | 27246105 |
| the mongolian gerbil: a robust model of helicobacter pylori-induced gastric inflammation and cancer. | the mongolian gerbil is an efficient, robust, and cost-effective rodent model that recapitulates many features of h. pylori-induced gastric inflammation and carcinogenesis in humans, allowing for targeted investigation of the bacterial determinants and environmental factors and, to a lesser degree, host constituents that govern h. pylori-mediated disease. this chapter discusses means through which the mongolian gerbil model has been used to define mechanisms of h. pylori-inflammation and cancer ... | 2016 | 27246040 |
| plant-derived urease inhibitors as alternative chemotherapeutic agents. | inhibition of the metalloenzyme urease has important pharmacologic applications in the field of antiulcer and antigastric cancer agents. urease is involved in many serious infections caused by helicobacter pylori in the gastric tract as well as by proteus and related species in the urinary tract. although numerous studies have described several novel urease inhibitors (uis) used for the treatment of gastric and urinary infections, all these compounds have exhibited severe side effects, toxicity, ... | 2016 | 27244041 |
| efficacy of probiotics as an adjuvant agent in eradication of helicobacter pylori infection and associated side effects. | the intestinal tract is a host to various types of bacteria that are essential to health. interactions between intestinal bacteria, i.e. the normal microbiota of the host's intestine, have been a subject of intensive research, as they may influence disease cycles. recent studies of selected probiotic species and their therapeutic benefits have suggested a potential efficacy in treatment of several gastrointestinal illnesses, including helicobacter pylori infection. the increasing evidence from t ... | 2016 | 27241906 |
| correlation between helicobacter pylori infection and polymorphism of adiponectin gene promoter -11391g/a, superoxide dismutase gene in nonalcoholic fatty liver disease. | to investigate the correlation between helicobacter pylori (h. pylori) infection and polymorphism of adiponectin gene promoter -11391g/a, extracellular superoxide dismutase (ec-sod) gene in nonalcoholic fatty liver disease (nafld). | 2016 | 27241145 |
| comparison of in vivo confocal endomicroscopy with other diagnostic modalities to detect intracellular helicobacters. | intracellular colonisation may serve as a protected niche where helicobacter spp. organisms evade effective treatment. in dogs, non-helicobacter pylori-helicobacters are frequently intracellular. confocal endomicroscopy allows in vivo gastrointestinal imaging and has aided real-time identification of helicobacter pylori and other intracellular and mucosally associated bacteria. the objectives of this study were: (1) to determine the utility of confocal endomicroscopy to identify non-helicobacter ... | 2016 | 27240920 |
| variability and conservation of structural domains in divide-and-conquer approaches. | the use of protein building blocks for the structure determination of multidomain proteins and protein-protein complexes, also known as the "divide and conquer" approach, is an important strategy for obtaining protein structures. atomic-resolution x-ray or nmr data of the individual domains are combined with lower-resolution electron microscopy maps or x-ray data of the full-length protein or the protein complex. doing so, it is often assumed that the individual domain structures remain invarian ... | 2016 | 27240588 |
| dyspepsia: when and how to test for helicobacter pylori infection. | dyspepsia is defined as symptoms related to the upper gastrointestinal tract. approximately 25% of western populations complain of dyspeptic symptoms each year. 70% of them do not have an organic cause and symptoms are related to the so-called functional dyspepsia, characterized by epigastric pain, early satiety, and/or fullness during or after a meal occurring at least weekly and for at least 6 months according to rome iii criteria. in order to avoid invasive procedures and adverse effects, to ... | 2016 | 27239194 |
| association between helicobacter pylori infection and multiple sclerosis: a systematic review and meta-analysis. | to investigate the association between helicobacter pylori infection and multiple sclerosis. | 2016 | 27237767 |
| prevalence of helicobacter pylori infection in patients with squamous cell carcinoma of the oesophagus. a descriptive case series study. | helicobacter pylori is an important causative factor in gastric carcinogenesis; its role in extra-gastric gastrointestinal malignancies such as oesophageal cancer is controversial. h. pylori is thought to cause extensive gastric atrophy associated with squamous cell carcinoma of the oesophagus. we conducted a study to determine the prevalence of h. pylori infection in patients with squamous cell carcinoma of the oesophagus. | 2016 | 27237135 |
| helicobacter pylori gastritis: susceptible to further testing? | 2016 | 27234271 | |
| effect of propolis in gastric disorders: inhibition studies on the growth of helicobacter pylori and production of its urease. | there is considerable interest in alternative approaches to inhibit helicobacter pylori (h. pylori) and thus treat many stomach diseases. propolis is a pharmaceutical mixture containing many natural bioactive substances. the aim of this study was to use propolis samples to treat h. pylori. the anti-h. pylori and anti-urease activities of 15 different ethanolic propolis extracts (epes) were tested. the total phenolic contents and total flavonoid contents of the epe were also measured. the agar-we ... | 2016 | 27233102 |
| helicobacter pylori couples motility and diffusion to actively create a heterogeneous complex medium in gastric mucus. | helicobacter pylori swims through mucus gel by generating ammonia that locally neutralizes the acidic gastric environment, turning nearby gel into a fluid pocket. the size of the fluid zone is important for determining the physics of the motility: in a large zone swimming occurs as in a fluid through hydrodynamic principles, while in a very small zone the motility could be strongly influenced by nonhydrodynamic cell-mucus interactions including chemistry and adhesion. here, we calculate the size ... | 2016 | 27232048 |
| a rapid and accurate method to evaluate helicobacter pylori infection, clarithromycin resistance, and cyp2c19 genotypes simultaneously from gastric juice. | because helicobacter pylori (h pylori) would cause carcinogenesis of the stomach, we need sufficient information for deciding on an appropriate strategy of eradication. many factors affect the efficacy of eradication including antimicrobial resistance (especially clarithromycin resistance) and cyp2c19 polymorphism. this study was to survey the efficiency of gastric juice for detecting h pylori infection, clarithromycin resistance, and cyp2c19 polymorphism.the specimens of gastric juice were coll ... | 2016 | 27227911 |
| a player and coordinator: the versatile roles of eosinophils in the immune system. | eosinophils have traditionally been associated with allergic diseases and parasite infection. research advances in the recent decades have brought evolutionary changes in our understanding of eosinophil biology and its roles in immunity. it is currently recognized that eosinophils play multiple roles in both innate and adaptive immunity. as effector cells in innate immunity, eosinophils exert a pro-inflammatory and destructive role in the th2 immune response associated with allergic inflammation ... | 2016 | 27226792 |
| urea and caga genes of helicobacter pylori in egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study. | this work aims to estimate the prevalence of helicobacter pylori urea gene and evaluate caga gene-positive strains in both patients of laryngeal squamous cell carcinoma (lscc) and those with benign laryngeal polyps. this study included 49 patients confirmed pathologically to have lscc and 15 patients with benign laryngeal polyps over a period from june 2013 to march 2015. samples of laryngeal tissue were collected during direct laryngoscope under general anesthesia to be pathologically evaluated ... | 2016 | 27225283 |
| epigenetic and genetic variation in gata5 is associated with gastric disease risk. | gastric cancer incidence varies considerably among populations, even those with comparable rates of helicobacter pylori infection. to test the hypothesis that genetic variation plays a role in gastric disease, we assessed the relationship between genotypes and gastric histopathology in a colombian study population, using a genotyping array of immune-related single nucleotide polymorphisms (snps). two synonymous snps (rs6061243 and rs6587239) were associated with progression of premalignant gastr ... | 2016 | 27225266 |
| gastroduodenal involvement in asymptomatic crohn's disease patients in two areas of emerging disease: asia and eastern europe. | the incidence of crohn's disease [cd] is increasing in asia and eastern europe. limited studies have reported on the frequency of upper gastrointestinal [gi] involvement in patients with cd in non-western countries. this prospective study compared the rate of macroscopic and microscopic upper gi manifestations and helicobacter pylori positivity in asymptomatic cd patients in asia and eastern europe. | 2016 | 27282400 |
| two cases of chronic gastritis with non-helicobacter pylori helicobacter infection. | two men, 48 and 54 years of age, were referred for medical checkups without any particular symptoms. upper gastrointestinal endoscopy showed a normal gastric body, but white marbled appearance in the lesser curvature of the gastric angle and antrum. biopsy specimens revealed relatively long and tightly coiled organisms. the two patients were diagnosed as having non-helicobacter pylori helicobacter (nhph) infection according to the findings of pathological and quantitative reverse transcription-p ... | 2016 | 27432094 |
| interleukin (il)-4 -590c>t polymorphism is not associated with the susceptibility of gastric cancer: an updated meta-analysis. | gastric cancer (gc) is a common cancer affecting patients around the world. the pathogenesis of gastric cancer has not been understood completely. genetic mutations and the inflammation induced by helicobacter pylori (hp) seem to play important roles. the cytokine interleukin-4 (il-4) has effects in inflammation, allergies and cancer including gc. the association of il-4 -590 c>t polymorphism and gastric cancer has been studied in different populations with inconsistent results. here, we report ... | 2016 | 27284401 |
| effect of helicobacter pylori on nfkb1, p38α and tnf-α mrna expression levels in human gastric mucosa. | helicobacter pylori infects ~50% of the world population, causing chronic gastritis and other forms of cellular damage. the present study assessed the influence of h. pylori on the mrna expression levels of nuclear factor-κb1 (nfkb1), p38α and tumor necrosis factor-α (tnf-α) in human gastric mucosa in a southern brazilian population. human gastric tissue was collected by upper endoscopy and h. pylori diagnosis was performed using a rapid urease test and histological analysis. total rna was extra ... | 2016 | 27284322 |
| extracellular galectin-3 counteracts adhesion and exhibits chemoattraction in helicobacter pylori-infected gastric cancer cells. | galectin-3 (gal-3) is a β-galactoside lectin that is upregulated and rapidly secreted by gastric epithelial cells in response to helicobacter pylori infection. an earlier study reported the involvement of h. pylori cytotoxin-associated gene a (caga) in the expression of intracellular gal-3. however, the role of extracellular gal-3 and its functional significance in h. pylori-infected cells remains uncharacterized. data presented here demonstrate secretion of gal-3 is an initial host response eve ... | 2016 | 27283429 |
| serum helicobacter pylori kata and ahpc antibodies as novel biomarkers for gastric cancer. | to investigate catalase (kata) and alkyl hydroperoxide reductase (ahpc) antibodies of helicobacter pylori as biomarkers for gastric cancer (gc). | 2016 | 27275098 |
| association between helicobacter pylori infection and metabolic syndrome: a systematic review and meta-analysis. | to systematically review and quantify the effect of helicobacter pylori (h. pylori) infection on the risk of metabolic syndrome (ms) and metabolic parameters in individuals with h. pylori infection. | 2016 | 27273478 |
| an overview of helicobacter pylori vaca toxin biology. | the vaca toxin secreted by helicobacter pylori enhances the ability of the bacteria to colonize the stomach and contributes to the pathogenesis of gastric adenocarcinoma and peptic ulcer disease. the amino acid sequence and structure of vaca are unrelated to corresponding features of other known bacterial toxins. vaca is classified as a pore-forming toxin, and many of its effects on host cells are attributed to formation of channels in intracellular sites. the most extensively studied vaca activ ... | 2016 | 27271669 |
| rifamycins, alone and in combination. | rifamycins inhibit rna polymerase of most bacterial genera. rifampicin remains part of combination therapy for treating tuberculosis (tb), and for treating gram-positive prosthetic joint and valve infections, in which biofilms are prominent. rifabutin has use for aids patients in treating mycobacterial infections tb and mycobacterium avium complex (mac), having fewer drug-drug interactions that interfere with aids medications. rifabutin is occasionally used in combination to eradicate helicobact ... | 2016 | 27270559 |
| [dyspepsia, ulcer disease – helicobacter pylori, gastroesophageal reflux disease]. | prevalence of h. pylori (hp) is declining, whereas reflux disease and the proportion of non-steroidal antiinflammatory drugs (nsar) to hp-induced ulcers increase. eradication heals hp-ulcer disease, interrupts cancerous progression and can improve dyspeptic symptoms. nsar-ulcers heal under proton pump inhibitor (ppi) therapy but tend to recur after reexposition. anticoagulants and antiplatlet agents increase the risk additionally. ppi reduces nsar-ulcer recurrence. reflux patients with severe in ... | 2016 | 27269775 |
| cxc chemokine cxcl12 tissue expression and circulating levels in peptic ulcer patients with helicobacter pylori infection. | helicobacter pylori (h. pylori) infection is among the most prevalent human infections. cxcl12 is a well-known cxc chemokine involved in inflammation and play major roles in angiogenesis. there is currently very limited data on the role of cxcl12 in peptic ulcer disease. hence, we aimed to explore whether cxcl12 is involved in the pathogenesis of peptic ulcer induced by h. pylori. in this study, we enrolled 102 h. pylori-infected patients, including 51 with active ulcer (ga) and 51 with healing ... | 2016 | 27269177 |
| profile of her2 +ve gastric cancers in brunei darussalam. | gastric cancer is the second most common gastrointestinal cancer and is still associated with significant morbidity and mortality due to late presentation and diagnosis at advanced stages. studies have reported that a variable proportion of gastric cancer is positive for the human epidermal growth factor receptor 2 (her2) and patients with her2 positive (her2 +ve) lesions can benefit from targeted therapy. this study was conducted to assess the prevalence of her2 +ve gastric cancers in brunei da ... | 2016 | 27268629 |
| thailand consensus on helicobacter pylori treatment 2015. | management of helicobacter pylori infection is an important aspect of many upper gastrointestinal tract diseases, such as chronic gastritis, peptic ulcer disease, gastric cancer and mucosa-associated lymphoid tissue (malt) lymphoma. the thailand consensus on h. pylori treatment 2015 consisted of 22 national experts who took active roles, discussed all important clinical information and investigated clinical aspects in four workshops, focuising on: (1) diagnosis (2) treatment (3) follow-up after ... | 2016 | 27268597 |
| [diabetes mellitus, helicobacter pylori, and gastric cancer]. | 2016 | 27266126 |