Publications

rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses.	protein structure is commonly regarded to be conserved and to dictate function. most proteins rely on conformational flexibility to some degree. are regions that convey conformational flexibility conserved over evolutionary time? can changes in conformational flexibility alter protein function? here, the evolutionary dynamics of structurally ordered and disordered (flexible) regions are investigated genome-wide in flaviviruses, revealing that the amount and location of structural disorder fluctu ...	23418179
tick-borne encephalitis vaccines.	tick-borne encephalitis (tbe) is a disease that is found from western europe across asia and into japan. in recent years the incidence rate has been increasing as has the endemic range of the virus. tick-borne encephalitis is caused by three genetically distinct sutypes of viruses within a single tbe virus (tbev) serocomplex. these three subtypes consist of far-eastern subtype tbev (tbev-fe), siberian subtype (tbev-sib) and european subtype (tbev-eu). each of these subtypes cause clinically dist ...	23997980
flavidb: a data mining system for knowledge discovery in flaviviruses with direct applications in immunology and vaccinology.	the flavivirus genus is unusually large, comprising more than 70 species, of which more than half are known human pathogens. it includes a set of clinically relevant infectious agents such as dengue, west nile, yellow fever, and japanese encephalitis viruses. although these pathogens have been studied extensively, safe and efficient vaccines lack for the majority of the flaviviruses.	25544857
epidemic infections and their relevance to the gulf and other arabian peninsula countries.		24019727
the impact of regulations, safety considerations and physical limitations on research progress at maximum biocontainment.	we describe herein, limitations on research at biosafety level 4 (bsl-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. these limitations can severely impact the number of collaborations and size of research projects investigating microbial pathogens of biodefense concern. acquisition, use, storage, and transfer of biological select agents and toxins (bsat) are hig ...	23342380