Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| investigation of cyp3a4 and cyp2d6 interactions of withania somnifera and centella asiatica in human liver microsomes. | withania somnifera is commonly used as a rejuvenator, whereas centella asiatica is well known for its anxiolytic and nootropic effects. the present study aims at investigating the effect of crude extracts and principal phytoconstituents of both the medicinal plants with cyp3a4 and cyp2d6 enzyme activity in human liver microsomes (hlm). phytoconstituents were quantified in the crude extracts of both the medicinal plants using reverse phase hplc. crude extracts and phytoconstituents of w. somnifer ... | 2015 | 25684704 |
| review on ethnomedicinal, phytochemical and pharmacological evidence of himalayan anticancer plants. | himalayan plants have 6500 years old history of being using as traditional medicines. inhabitants of the region use indigenous knowledge for the preparation of various herbal recipes in order to treat different kinds of cancer. the aim of this review is to provide ethnopharmacological, phytochemical and toxicological overview of himalayan medicinal plants having anticancer potential. this will provide a baseline for the discovery of new anticancer drugs. | 2015 | 25680842 |
| centella asiatica attenuates amyloid-β-induced oxidative stress and mitochondrial dysfunction. | we previously showed that a water extract of the medicinal plant centella asiatica (caw) attenuates amyloid-β (aβ)-induced cognitive deficits in vivo, and prevents aβ-induced cytotoxicity in vitro. yet the neuroprotective mechanism of caw is unknown. | 2015 | 25633675 |
| intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: a unique action mode of saponin compounds with poor bioavailability. | madecassoside, a triterpenoid saponin present in centella asiatica herbs with extremely low bioavailability, possesses excellent anti-rheumatoid arthritis property after oral administration. such a disconnection between poor pharmacokinetic property and undoubted bioactivity also exists in many other herbal medicines. however, there is no reasonable explanation for this phenomenon to date. here we showed that orally administered madecassoside displayed marked therapeutic effect on collagen-induc ... | 2015 | 25600909 |
| biopharmaceutical and pharmacokinetic characterization of asiatic acid in centella asiatica as determined by a sensitive and robust hplc-ms method. | asiatic acid is one of the main components in the herb centella asiatica, which is a well-known herbal medicine for its excellent pharmacological effects. to enhance the development potentials of asiatic acid as a chemopreventative agent, there is a great need to further understand its biopharmaceutical and pharmacokinetic properties. the aim of this research is to clarify the mechanisms of absorption and metabolism of asiatic acid, and explore its biopharmaceutical and pharmacokinetic propertie ... | 2015 | 25596352 |
| e-microsatellite markers for centella asiatica (gotu kola) genome: validation and cross-transferability in apiaceae family for plant omics research and development. | abstract centella asiatica (gotu kola) is a plant that grows in tropical swampy regions of the world and has important medicinal and culinary use. it is often considered as part of ayurvedic medicine, traditional african medicine, and traditional chinese medicine. the unavailability of genomics resources is significantly impeding its genetic improvement. to date, no attempt has been made to develop expressed sequence tags (ests) derived simple sequence repeat (ssr) markers (essrs) from the cente ... | 2015 | 25562200 |
| pycnogenol® and centella asiatica in the management of asymptomatic atherosclerosis progression. | the aim of the study was to evaluate the effect of the nutritional supplements pycnogenol® and total triterpenic fraction of centella asiatica (ttfca) on atherosclerosis progression in low-risk asymptomatic subjects with carotid or femoral stenosing plaques. | 2015 | 25519846 |
| simultaneous interstitial pneumonitis and cardiomyopathy induced by venlafaxine. | venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an antidepressant. interindividual variability and herb-drug interactions can lead to drug-induced toxicity. we report the case of a 35-year-old female patient diagnosed with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. the patient sought medical attention due to dyspnea and dry cough that started three months after initiating treatment with venlafaxine for depression. the patient was concomitantl ... | 2015 | 25029655 |
| synthesis and evaluation of asiatic acid derivatives as anti-fibrotic agents: structure/activity studies. | fibrotic diseases are characterized by the over-accumulation of fibrous components in the extracellular matrix and the liver, which can lead to liver cirrhosis. current treatment options cannot reverse or halt liver fibrosis, motivating a search for newer treatment options. previously, we showed that asiaticoside, a bioactive triterpene glycoside from centella asiatica, has anti-fibrotic properties. here, the aglycone asiatic acid was chemically modified, and these derivatives were evaluated for ... | 2015 | 25461275 |
| production of polyclonal antibody against madecassoside and development of immunoassay methods for analysis of triterpene glycosides in centella asiatica. | centella asiatica (l.) urban consists of two major triterpene glycosides, asiaticoside (as) and madecassoside (ma), as active components used for wound healing and enhancing memory. | 2015 | 23081750 |
| night eating syndrome and gotu kola. | 2015 | 16445150 | |
| new innovations in scar management. | as current aesthetic surgical techniques become more standardized and results more predictable, a fine scar may be the demarcating line between acceptable and unacceptable aesthetic results. with this in mind, a scar management program has been adopted based on the modalities of wound support, hydration, and hastened maturity, all factors gleaned from scientific evidence published over the past 25 years. tension on a scar in one axis will result in a stretched scar, probably initiated by neutrop ... | 2015 | 10890953 |
| dietary supplements used in the treatment of depression, anxiety, and sleep disorders. | dietary supplement use has increased during the past decade. epidemiologic studies suggest that patients turn to dietary supplements because of a reluctance to take prescription medications or a lack of satisfaction with the results. they often perceive dietary supplements to be a safer or more natural alternative. patients with mental health conditions, including depression, anxiety, and sleep disorders, are among those who use dietary supplements. st. john's wort is used to treat depression. c ... | 2015 | 10711131 |
| [anthrone determination of the asiaticoside isolated from centella asiatica by quantitative chromatography on thin layers of glass powder]. | 2015 | 14048142 | |
| testing wound-healing activity in t15 fibroblast cultures: a morphometric analysis. | the purpose was to evaluate the use of mouse t15 fibroblast cell cultures for the investigation of wound-healing activity. in order to investigate their mechanisms of action, the effects of drugs with wound-healing activities were compared by using morphometric analyses by microscopy after cell staining. a number of parameters were used to evaluate the effects of titrated extracts from centella asiatica and dexpanthenol (drugs that have been used in medical practice for their wound-healing activ ... | 2014 | 25406104 |
| total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants. | free radical scavenging activity of 21 tropical plant extracts was evaluated using 1,1-diphenyl-2-picrylhydrazyl assay (dpph). total phenolic compounds and flavonoids were determined using folin-ciocalteu and hplc, respectively. results of the study revealed that all the plants tested exhibited excellent antioxidant activity with ic(50) in the range of 21.3 to 89.6 microg/ml. the most potent activity was demonstrated by cosmos caudatus (21.3 microg/ml) and piper betle (23.0 microg/ml) that are n ... | 2014 | 20492146 |
| field evaluation of in vitro-induced tetraploid and diploid centella asiatica (l.) urban. | centella asiatica-a medicinal plant that produces high-value active triterpenoids-is in increasing demand by the pharmaceutical and cosmetic industries. the aim of this study was to field-test one induced tetraploid and three diploid c. asiatica lines for the selection of high-quality plants with high phytomass and triterpenoid content and to determine their optimal harvesting time. all tested c. asiatica were micropropagated using an established protocol. one-month-old plantlets were acclimatiz ... | 2014 | 23529542 |
| [simultaneous determination of madecassoside, asiaticoside and their aglycones in centella asiatica (l.) urban extracts by rp-hplc]. | to establish a hplc method for simultaneous determination of four major constituents (madecassoside, asiaticoside, madecassic acid and asiatic acid) in centella asiatica (l.) urban extracts. | 2014 | 24782366 |
| hypolipidemic and hypoglycemic effects of centella asiatica (l.) extract in vitro and in vivo. | in vitro study revealed that pancreatic lipase inhibitory activity of c. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. alpha-amylase inhibitory activities of c. asiatica extract and rutin were significantly lower than acarbose, an anti-diabetic drug. inhibition of alpha-glucosidase activity by c. asiatica extract, rutin, and acarbose was not different. the in vivo study substantiated the in vitro results. c. asiatica extract (1000 and 2000 mg ... | 2014 | 25345245 |
| study of the cytotoxicity of asiaticoside on rats and tumour cells. | cancer chemoprevention is considered one of the most promising areas in current cancer research, and asiaticoside, which is derived from the plant centella asiatica, has a relative lack of systemic toxicity. the purpose of this study was to investigate whether asiaticoside is effective against 7,12-dimethylbenz(a)anthracene (dmba)-induced carcinogenicity in vitro (mcf-7 and other cells) and in vivo (dmba-induced rat cancer). | 2014 | 24667059 |
| asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism. | asiaticoside (as) is isolated from centella asiatica (l.) which has been using for a long time as a memory enhancing drug in india. this study was to investigate the effects of as on memory impairment and inflammatory cytokines expression induced by transient cerebral ischemia and reperfusion in mice, as well as the potential signaling pathway. transient bilateral common carotid artery occlusion (tbccao) induced severe memory deficits in mice according to the morris water maze task and the step- ... | 2014 | 24631487 |
| the effect of centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast. | centella asiatica (linn.) urban is well known in promoting wound healing and provides significant benefits in skin care and therapeutic products formulation. glycolic acid and vitamins also play a role in the enhancement of collagen and fibronectin synthesis. here, we evaluate the specific effect of centella asiatica (ca), vitamins, glycolic acid and their mixture preparations to stimulate collagen and fibronectin synthesis in cultured human fibroblast cells. the fibroblast cells are incubated w ... | 2014 | 24577907 |
| centella asiatica in dermatology: an overview. | centella asiatica is a medicinal plant that was already used as a 'panacea' 3000 years ago. the active compounds include pentacyclic triterpenes, mainly asiaticoside, madecasosside, asiatic acid and madecassic acid. we have conducted an overview to summarize current knowledge on the results of scientific in vitro and in vivo experiments focused on the improvement of the healing process of small wounds, hypertrophic scars and burns by c. asiatica. in this paper, we discuss the data on constituent ... | 2014 | 24399761 |
| anti-inflammaging and antiglycation activity of a novel botanical ingredient from african biodiversity (centevita™). | the aim of this study was to investigate the topical efficacy of a new purified extract from madagascar, gotu kola (centella asiatica [l.] urban), both on human explants and on human volunteers, in relation to skin wrinkling and skin protection against ultraviolet light exposure. the extract, with a peculiar content of biologically active molecules, was investigated as a novel anti-inflammaging and antiglycation agent. its typical terpenes, known as collagen synthesis promoters, represent at lea ... | 2014 | 24376360 |
| madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice by downregulating collagen deposition. | this study aimed to explore the protective effects of madecassoside (mad), a triterpenoid saponin isolated from centella asiatica herbs, on experimental pulmonary fibrosis (pf) and underlying mechanisms. pf model was established in mice by endotracheal instillation with bleomycin (5 mg/kg). mice were orally administered with mad (10, 20, 40 mg/kg) and prednisone (5 mg/kg) for 7 or 21 days. mad (20, 40 mg/kg) significantly improved lung pathological changes and reduced collagen deposition. in the ... | 2014 | 24458872 |
| pycnogenol® and centella asiatica for asymptomatic atherosclerosis progression. | the aim of the study was to evaluate the effect of the nutritional supplements pycnogenol and teca (total triterpenic fraction of centella asiatica) on atherosclerosis progression in low-risk asymptomatic subjects with carotid or femoral non-stenosing plaques. | 2014 | 24452082 |
| caffeoylquinic acids in centella asiatica protect against amyloid-β toxicity. | the accumulation of amyloid-β (aβ) is a hallmark of alzheimer's disease and is known to result in neurotoxicity both in vivo and in vitro. we previously demonstrated that treatment with the water extract of centella asiatica (caw) improves learning and memory deficits in tg2576 mice, an animal model of aβ accumulation. however the active compounds in caw remain unknown. here we used two in vitro models of aβ toxicity to confirm this neuroprotective effect and identify several active constituents ... | 2014 | 24448790 |
| the centella asiatica juice effects on dna damage, apoptosis and gene expression in hepatocellular carcinoma (hcc). | this paper is to investigate the effects of centella asiatica on hepg2 (human hepatocellular liver carcinoma cell line). centella asiatica is native to the southeast asia that is used as a traditional medicine. this study aims to determine the chemopreventive effects of the centella asiatica juice on human hepg2 cell line. | 2014 | 24444147 |
| asiatic acid alleviates hemodynamic and metabolic alterations via restoring enos/inos expression, oxidative stress, and inflammation in diet-induced metabolic syndrome rats. | asiatic acid is a triterpenoid isolated from centella asiatica. the present study aimed to investigate whether asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (ms) induced by a high-carbohydrate, high-fat (hchf) diet. male sprague-dawley rats were fed with hchf diet with 15% fructose in drinking water for 12 weeks to induce ms. ms rats were treated with asiatic acid (10 or 20 mg/kg/day) or vehicle for a further three weeks. ms rats had an imp ... | 2014 | 24441717 |
| anti-hyperglycemic activity of centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding. | centella asiatica (c. asiatica) was previously reported to have anti-hyperglycemic effects in animal diabetic model rats. however, its activity on organ and tissue level remains unstudied. our study aims at exploring the possible effects, c. asiatica extract and insoluble fiber has on carbohydrate absorption, insulin secretion, insulin sensitivity and glucose utilization. | 2014 | 24438380 |
| in vitro evidence that an aqueous extract of centella asiatica modulates α-synuclein aggregation dynamics. | α-synuclein aggregation is one of the major etiological factors implicated in parkinson's disease (pd). the prevention of aggregation of α-synuclein is a potential therapeutic intervention for preventing pd. the discovery of natural products as alternative drugs to treat pd and related disorders is a current trend. the aqueous extract of centella asiatica (ca) is traditionally used as a brain tonic and ca is known to improve cognition and memory. there are limited data on the role of ca in modul ... | 2014 | 24284367 |
| unraveling the binding mechanism of asiatic acid with human serum albumin and its biological implications. | asiatic acid (asa), a naturally occurring pentacyclictriterpenoid found in centella asiatica, plays a major role in neuroprotection, anticancer, antioxidant, and hepatoprotective activities. human serum albumin (hsa), a blood plasma protein, participates in the regulation of plasma osmotic pressure and transports endogenous and exogenous substances. the study undertaken to analyze the drug-binding mechanisms of hsa is crucial in understanding the bioavailability of drugs. in this study, we analy ... | 2014 | 23844909 |
| microrna-1290 promotes asiatic acid‑induced apoptosis by decreasing bcl2 protein level in a549 non‑small cell lung carcinoma cells. | asiatic acid, a triterpenoid derived from centella asiatica, is a putative anticancer agent in several types of cancer cells. investigations of its biological role in negative regulation of cell growth have focused on the extent of induction of apoptosis in a cell-type-specific manner. in this study, we identified an important regulator of asiatic acid-induced cell death, microrna (mir)-1290, which sensitizes cells to asiatic acid-induced cytotoxicity and negatively regulates bcl2 expression. as ... | 2014 | 25016979 |
| effect of centella asiatica on oxidative stress and lipid metabolism in hyperlipidemic animal models. | hyperlipidemia and many other metabolic diseases are related to oxidative stress. centella asiatica is a traditional chinese medicine whose antioxidant effect in vitro has been reported. we are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect. we observed that a fraction (caf3) of the ethanol extract (cae) of centella asiatica had a ch ... | 2014 | 24829618 |
| asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo. | cardiac hypertrophy is a major cause of morbidity and mortality worldwide. transforming growth factor-β1 (tgf-β1) signaling has been considered as a trigger causally contributing to pathological cardiac hypertrophy. asiatic acid (aa) is a triterpenoid compound extracted from centella asiatica and exhibits a variety of pharmacological effects. in this study, we investigated the anti-hypertrophic effects and mechanisms of action of aa in a tgf-β1-stimulated hypertrophic response using cultured neo ... | 2014 | 24827470 |
| asiaticoside, a component of centella asiatica, inhibits melanogenesis in b16f10 mouse melanoma. | melanogenesis is the process of generating pigmentation via melanin synthesis and delivery. three key enzymes, tyrosinase, tyrosinase-related protein 1 (trp1) and trp2, metabolize melanin from l-tyrosine. melanin synthesizing enzymes are regulated by microphthalmia-associated transcription factor (mitf). the titrated extract of centella asiatica (teca) contains the major components asiatic acid, asiaticoside and madecassic acid. the present study revealed that teca reduces the melanin content in ... | 2014 | 24756377 |
| comparative study on anti-oxidant and anti-inflammatory activities of caesalpinia crista and centella asiatica leaf extracts. | amyloidosis, oxidative stress and inflammation have been strongly implicated in neurodegenerative disorders like alzheimer's disease. traditionally, caesalpinia crista and centella asiatica leaf extracts are used to treat brain related diseases in india. c. crista is used as a mental relaxant drink as well as to treat inflammatory diseases, whereas c. asiatica is reported to be used to enhance memory and to treat dementia. | 2014 | 24741275 |
| neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats. | madecassoside, a triterpenoid derivative isolated from centella asiatica, exhibits anti-inflammatory and antioxidant activities. we investigated its neuroprotective effect against ischemia-reperfusion (i/r) injury in cerebral neurons in male sprague-dawley rats. madecassoside (6, 12, or 24mg/kg, i.v.) was administered 1h after the start of reperfusion, and neurological deficit score and infarct volume were evaluated 24h later. neuronal apoptosis was assessed by performing terminal deoxynucleotid ... | 2014 | 24735651 |
| study of ameliorating effects of ethanolic extract of centella asiatica on learning and memory deficit in animal models. | the present study investigated the effect of centella asiatica ethanolic extract (ce) on learning and memoly imnpairment induced by either transient bilateral common carotid arteries occlusion (t2 vo) or an intraperitoneal injection of scopolamine in mice. | 2014 | 25518178 |
| attenuation of collagen induced arthritis by centella asiatica methanol fraction via modulation of cytokines and oxidative stress. | to investigate the anti-inflammatory, antioxidant and anti-arthritic effects of centella asiatica methanolfraction (came) on collagen-induced arthritis (cia), an animal model of rheumatoid arthritis. | 2014 | 25484009 |
| microwave blanching and drying characteristics of centella asiatica (l.) urban leaves using tray and heat pump-assisted dehumidified drying. | the appropriate stage of maturity of centella asiatica (l.) urban leaves was investigated. mature leaves with large diameter contained high total phenolics and % inhibition. microwave blanching for 30 s retained the highest total phenolics and the microwave blanching for 30 s and 45 s retained the highest % inhibition. modified henderson and modified chung-pfost models showed the best fit to both fresh and blanched leaves for equilibrium moisture content, xe = f(rhe, t) and equilibrium relative ... | 2014 | 25477629 |
| the effects of intellan and cytacon on hematological and biochemical parameter in rabbits: a comparative study. | several plants have been selected based on their use in traditional systems of medicine, and research has identified a number of natural compounds that could act as nootropicagents. in this study a herbal product intellan containing centella asiatica, bacopa monniera, coriandum sativum, amomum subulatum, emblica officinalis and another product cytacon (cyanocobalamine) were selected the study was designed on animal models to explore the effects on different parameters. for this the animals were ... | 2014 | 25176357 |
| centella asiatica attenuates diabetes induced hippocampal changes in experimental diabetic rats. | diabetes mellitus has been reported to affect functions of the hippocampus. we hypothesized that centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. therefore, the aim of this study was to investigate the protective role of c. asiatica on the hippocampus in diabetes. methods. streptozotocin- (stz-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) c. asiatica leaf aqueous extract for four consecu ... | 2014 | 25161691 |
| morphological, chemical and molecular characterization of centella asiatica germplasms for commercial cultivation in the indo-gangetic plains. | centella asiatica germplasm collected from north, north-eastern and southern parts of india was compared for biomass and centellosides productivity under uniform agro-climatic conditions of the indo-gangetic plains at lucknow. the highest biomass accumulation (411.9 g fw/m2 area) was recorded in accession a from north india, followed by 284.0, 135.7 and 29.2 g fw/m2 in accessions m, b and e from southern, eastern and north-eastern regions, respectively. accession m possessed the highest asiatico ... | 2014 | 25115077 |
| effects of five ayurvedic herbs on locomotor behaviour in a drosophila melanogaster parkinson's disease model. | current conventional treatments for parkinson's disease (pd) are aimed at symptom management, as there is currently no known cure or treatment that can slow down its progression. ayurveda, the ancient medical system of india, uses a combination of herbs to combat the disease. herbs commonly used for this purpose are zandopa (containing mucuna pruriens), withania somnifera, centella asiatica, sida cordifolia and bacopa monnieri. in this study, these herbs were tested for their potential ability t ... | 2014 | 25091506 |
| effect of centella asiatica leaf extract on the dietary supplementation in transgenic drosophila model of parkinson's disease. | the role of centella asiatica l. leaf extract was studied on the transgenic drosophila model flies expressing normal human alpha synuclein (h-αs) in the neurons. the leaf extract was prepared in acetone and was subjected to gc-ms analysis. c. asiatica extract at final concentration of 0.25, 0.50, and 1.0 μl/ml was mixed with the diet and the flies were allowed feeding on it for 24 days. the effect of extract was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbo ... | 2014 | 25538856 |
| ethnopharmacological survey of medicinal plants used by traditional health practitioners in thanchi, bandarban hill tracts, bangladesh. | there is very limited information regarding plants used by traditional healers in bandarban hill tracts (bht), bangladesh for treating general as well as complex ailments. current study provides significant ethnopharmacological information, both qualitative and quantitative on medical plants in bht. aim of the study this study aimed to collect, analyze and evaluate the rich ethnopharmacologic knowledge on medicinal plants in thanchi, bht and attempted to identify the important species used in tr ... | 2014 | 24892834 |
| effects of dietary centella asiatica (l.) urban on growth performance, nutrient digestibility, blood composition in piglets vaccinated with mycoplasma hyopneumoniae. | to investigate the effects of centella asiatica (l.) on growth performance, nutrient digestibility and blood composition in piglets, 32 nursery pigs were fed 0.0, 0.5, 1.0 and 2.0% dietary c. asiatica (l.) from 15 to 90 kg bw. at 30 kg bw, nutrient digestibility was measured and at 35 kg bw piglets were vaccinated with mycoplasma hyopneumoniae. hematological parameters were checked at 40 and 80 kg bw. compared with the control, growth performance was not affected. the ether extract, ash and calc ... | 2014 | 24612418 |
| formulation, standardization and pharmacological studies of saraswataristam: a polyhedral preparation. | ayurvedic preparations achieved paramount importance in contemporary life owing to the safety and efficacy when compared with those of synthetic drugs. but due to lack of proper standardization at each stage from starting to culmination results in inferior quality and less demand. saraswataristam, a fermented ayurvedic preparation, has been employed for treating central nervous system disorders and dermatological problems. saraswataristam, containing centella asiatica (l) urban (umbelliferae) as ... | 2014 | 25176373 |
| formulation, standardization and pharmacological studies of saraswataristam: a polyhedral preparation. | ayurvedic preparations achieved paramount importance in contemporary life owing to the safety and efficacy when compared with those of synthetic drugs. but due to lack of proper standardization at each stage from starting to culmination results in inferior quality and less demand. saraswataristam, a fermented ayurvedic preparation, has been employed for treating central nervous system disorders and dermatological problems. saraswataristam, containing centella asiatica (l) urban (umbelliferae) as ... | 2014 | 24811816 |
| effectiveness of traditional malaysian vegetables (ulam) in modulating blood glucose levels. | ulam refers to a group of traditional malaysian plants commonly consumed as a part of a meal, either in the raw form or after a short blanching process. many types of ulam are thought to possess blood glucose-lowering properties, but relatively little is known on the effectiveness of ulam in modulating blood glucose levels in humans. this review aims to systematically evaluate the effectiveness of ulam in modulating blood glucose levels in humans. a literature review was conducted using multiple ... | 2014 | 25164446 |
| ecological succession and its impact on malaria vectors and their predators in borrow pits in western ethiopia. | soil pits excavated for home construction are important larval habitats for malaria vectors in certain parts of africa. borrow pits in diverse stages of ecological succession in a maize-farming region of western ethiopia were surveyed to assess the relationships between stage of succession and the structure and composition of invertebrate and plant communities, with particular attention to anopheles gambiae s.l. and an. coustani, the primary local malaria vectors. an array of 82 borrow pits was ... | 2014 | 25424271 |
| determination of trace and heavy metals in some commonly used medicinal herbs in ayurveda. | traditionally, the herbal drugs are well established for their therapeutic benefits. depending upon their geographical sources sometimes the trace and heavy metals' content may differ, which may lead to severe toxicity. so, the toxicological and safety assessment of these herbal drugs are one of the major issues in recent days. eight different plant species including aloe vera, centella asiatica, calendula officinalis, cucumis sativus, camellia sinensis, clitoria ternatea, piper betel and tagete ... | 2014 | 23222691 |
| medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. | burn wound healing is a complicated process including inflammation, re-epithelialization, granulation, neovascularization and wound contraction. several biochemicals are involved in burn healing process including antioxidants, cytokines and liver and kidney damage biomarkers. although several preparations are available for the management of burn wound, there is still a necessity of researching for efficacious medicine. the aim of the present study was to evaluate herbal preparations and their ph ... | 2014 | 24895176 |
| ethnoveterinary medicinal plants used by the maale and ari ethnic communities in southern ethiopia. | livestock production is an integral part of the agricultural system in ethiopia. medicinal plants are used and are important for rural communities for the treatment of livestock diseases. we studied and analysed the traditional medicinal plants used for the treatment of livestock diseases by the maale and ari ethnic communities in southern ethiopia. | 2014 | 24576407 |
| useful ethnophytomedicinal recipes of angiosperms used against diabetes in south east asian countries (india, pakistan & sri lanka). | this paper is based on data recorded from various literatures pertaining to ethnophytomedicinal recipes used against diabetes in south east asia (india, pakistan and srilanka). traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. in total 419 useful phytorecipes of 270 plant species belonging to 74 angiospermic families were collected. from the review it was revealed that plants showing hypoglycemic potential mainly belong to the families, cucurb ... | 2014 | 25176368 |
| common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits. | ambulatory surgery patients often use complementary and alternative medicine (cam) therapies. cam therapies may create beneficial and detrimental perioperative conditions. | 2013 | 21890235 |
| microbial transformation of asiatic acid. | asiatic acid (1), a major pentacyclic triterpene of centella asiatica, was subjected to transformation by penicillium lilacinum accc 31890, fusarium equiseti cgmcc 3.3658, and streptomyces griseus cgmcc 4.18 strains. incubation of asiatic acid with p. lilacinum accc 31890 and f. equiseti cgmcc 3.3658 gave an identical product: 2α,3β,15α,23-tetrahydroxyurs-12-en-28-oic acid (2). biotransformation of asiatic acid by s. griseus cgmcc 4.18 resulted in three derivatives: 2α,3β,21β,23-tetrahydroxyurs- ... | 2013 | 23227815 |
| study in vitro of the impact of endophytic bacteria isolated from centella asiatica on the disease incidence caused by the hemibiotrophic fungus colletotrichum higginsianum. | thirty-one endophytic bacteria isolated from healthy leaves of centella asiatica were screened in vitro for their ability to reduce the growth rate and disease incidence of colletotrichum higginsianum, a causal agent of anthracnose. isolates of cohnella sp., paenibacillus sp. and pantoea sp. significantly stimulated the growth rate of c. higginsianum mucl 44942, while isolates of achromobacter sp., acinetobacter sp., microbacterium sp., klebsiella sp. and pseudomonas putida had no influence on t ... | 2013 | 22903452 |
| antioxidant activity of herbaceous plant extracts protect against hydrogen peroxide-induced dna damage in human lymphocytes. | herbaceous plants containing antioxidants can protect against dna damage. the purpose of this study was to evaluate the antioxidant substances, antioxidant activity, and protection of dna from oxidative damage in human lymphocytes induced by hydrogen peroxide (h2o2). our methods used acidic methanol and water extractions from six herbaceous plants, including bidens alba (ba), lycium chinense (lc), mentha arvensis (ma), plantago asiatica (pa), houttuynia cordata (hc), and centella asiatica (ca). | 2013 | 24279749 |
| the pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications. | pentacyclic triterpenoids including the oleanane, ursane and lupane groups are widely distributed in many medicinal plants, such as glycyrrhiza species, gymnema species, centella asiatica, camellia sinensis, crataegus species and olea europaea, which are commonly used in traditional medicine for the treatment of diabetes and diabetic complications. a large number of bioactive pentacyclic triterpenoids, such as oleanolic acid, glycyrrhizin, glycyrrhetinic acid, ursolic acid, betulin, betulinic ac ... | 2013 | 23210780 |
| effects of medhya rasayana and yogic practices in improvement of short-term memory among school-going children. | excellent memory, extraordinary intelligence, great academic achievement, and successful career are the dreams of every individual in this era of competition and professionalism. a good memory power acts as a catalyst in all walks of life, be it academic success or maintenance of personal relationships. it is observed that an average man uses only 10% of his natural memory. remaining 90% is left unused in a haphazard manner. as per the american psychologist carl emil seashore, if one is alert an ... | 2013 | 24695779 |
| long-term follow-up of oral administration of flavonoids, centella asiatica and melilotus, for diabetic cystoid macular edema without macular thickening. | to evaluate long-term follow-up of the orally administered combination of flavonoids with centella asiatica and melilotus for treatment of diabetic cystoid macular edema (cme) without macular thickening. | 2013 | 23844756 |
| matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of centella asiatica. | centella asiatica (l.) urban (apiaceae), a valuable herb described in ayurveda, is used in the indigenous system of medicine as a tonic to treat skin diseases. | 2013 | 23763301 |
| plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. | research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. however, a comprehensive review of plant-based anxiolytics has been absent to date. thus, our aim was to provide a comprehensive narrative review of plant-based medicines that have clinical and/or preclinical evidence of anxiolytic activity. we present the article in two parts. in part one, we reviewed herbal ... | 2013 | 23653088 |
| de novo sequencing and assembly of centella asiatica leaf transcriptome for mapping of structural, functional and regulatory genes with special reference to secondary metabolism. | centella asiatica (l.) urban is an important medicinal plant and has been used since ancient times in traditional systems of medicine. c. asiatica mainly contains ursane skeleton based triterpenoid sapogenins and saponins predominantly in its leaves. this investigation employed illumina next generation sequencing (ngs) strategy on a pool of three cdnas from expanding leaf of c. asiatica and developed an assembled transcriptome sequence resource of the plant. the short transcript reads (strs) gen ... | 2013 | 23644021 |
| centelloside accumulation in leaves of centella asiatica is determined by resource partitioning between primary and secondary metabolism while influenced by supply levels of either nitrogen, phosphorus or potassium. | in the present study we aimed to investigate the relevance of either n, p or k supply for herb and leaf yield and for centelloside concentrations in centella asiatica l. urban leaves. in this regard, we elucidated the causal relationship between assimilation rate, leaf n, p and k concentrations, herb and leaf production, and centelloside accumulation. the experiments were conducted consecutively in a greenhouse where c. asiatica was grown in hydroponic culture and fertigated with nutrient soluti ... | 2013 | 23608744 |
| [near-infrared spectroscopy technology for online monitoring of the column separation and purification process of active components of centella asiatica l. urban]. | the present paper is to study and develop a method for online monitoring of the column separation and purification process of active components that are madecassoside and asiaticoside of centella asiatica l. urban using near-infrared (nir) spectroscopy technology. after collecting 50%-ethanol eluant, we detected their nir spectra and developed the high performance liquid chromatography (hplc) assay method of active components. then, partial least square (pls) was used to develop linear correlati ... | 2013 | 23586234 |
| metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb centella asiatica (l.) urban. | centella asiatica is an important source of biologically active pentacyclic triterpenoids. the enhancement of the biosynthesis of the centellosides by manipulation of associated metabolic pathways is receiving much attention. jasmonates play critical roles in plant metabolism by up-regulating the expression of genes related to secondary metabolites. here, we investigated the effect of methyl jasmonate (meja) in c. asiatica through targeted metabolomic profiling of asiaticoside and madecassoside ... | 2013 | 23579994 |
| statistical analysis of metal chelating activity of centella asiatica and erythroxylum cuneatum using response surface methodology. | the purpose of the study is to evaluate the relationship between the extraction parameters and the metal chelating activity of centella asiatica (ca) and erythroxylum cuneatum (ec). the response surface methodology was used to optimize the extraction parameters of methanolic extract of ca and ec with respect to the metal chelating activity. for ca, run 17 gave optimum chelating activity with ic50 = 0.93 mg/ml at an extraction temperature of 25°c, speed of agitation at 200 rpm, ratio of plant mat ... | 2013 | 23533781 |
| a systematic review of the efficacy of centella asiatica for improvement of the signs and symptoms of chronic venous insufficiency. | we aimed to assess the efficacy of centella asiatica for improvement of the signs and symptoms of chronic venous insufficiency (cvi). we searched 13 electronic databases including the cochrane central register of controlled trials for randomised controlled trials assessing the efficacy of centella asiatica for cvi. two review authors independently selected studies, assessed the risks of bias of included studies and extracted data. the treatment effects of similar studies were pooled whenever app ... | 2013 | 23533507 |
| centella asiatica in cosmetology. | centella asiatica known as gotu kola is a medicinal plant that has been used in folk medicine for hundreds of years as well as in scientifically oriented medicine. the active compounds include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids. centella asiatica is effective in improving treatment of small wounds, hypertrophic wounds as well as burns, psoriasis and scleroderma. the mechanism of action involves promoting fibroblast proliferation and increasi ... | 2013 | 24278045 |
| asiatic acid, a triterpene, inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells. | the aim of the present study was to investigate whether asiatic acid (aa), a pentacyclic triterpene derived from centella asiatica, exerts anti-proliferative effects on multiple myeloma rpmi 8226 cells and to determine the molecular mechanism underlying the anticancer action of aa. the study sought to analyze the potential role of aa on the proliferation of the rpmi 8226 cells using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h-tetrazolium assay. cell cycle arrest was detected by flow cytometry ... | 2013 | 24260073 |
| asiatic acid isolated from centella asiatica inhibits tgf-β1-induced collagen expression in human keloid fibroblasts via ppar-γ activation. | keloids are fibroproliferative disorders characterized by exuberant extracellular matrix deposition and transforming growth factor (tgf)-β/smad pathway plays a pivotal role in keloid pathogenesis. centella asiatica extract has been applied in scar management for ages. as one of its major components, asiatic acid (aa) has been recently reported to inhibit liver fibrosis by blocking tgf-β/smad pathway. however, its effect on keloid remains unknown. in order to investigate the effects of aa on cell ... | 2013 | 24250248 |
| asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction. | asiatic acid (aa) is one of the triterpenoid compounds present in centella asiatica and it has been shown to be capable of attenuating liver fibrosis. in the present study, we investigated the effects of aa on renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction (uuo). mice were divided randomly into five groups (n=5 per group): the sham-surgery (sh), uuo plus vehicle treatment (uuo+v), uuo plus 1 mg/kg body weight aa treatment (uuo+a1), uuo plus 4 mg/kg body weight aa ... | 2013 | 24137256 |
| in vivo disposition and metabolism of madecassoside, a major bioactive constituent in centella asiatica (l.) urb. | centella asiatica (l.) urb. herb is frequently used in traditional chinese medicine for many indications, such as traumatic injuries, keloid and scar. madecassoside is the main active ingredient of this herb drug with higher content than other triterpenoid constituents. understandings of pharmacokinetic profiles of madecassoside should be beneficial for its development as a therapeutic agent. | 2013 | 24091240 |
| production of asiaticoside from centella (centella asiatica l. urban) cells in bioreactor. | to investigate the effects of some culture conditions on production of asiaticoside from centella (centella asiatica l. urban) cells cultured in 5-l bioreactor. | 2013 | 24075346 |
| ecologically relevant uv-b dose combined with high par intensity distinctly affect plant growth and accumulation of secondary metabolites in leaves of centella asiatica l. urban. | we investigated the effects of environmentally relevant dose of ultraviolet (uv)-b and photosynthetic active radiation (par) on saponin accumulation in leaves on the example of centella asiatica l. urban. for this purpose, plants were exposed to one of four light regimes i.e., two par intensities with or without uv-b radiation. the experiment was conducted in technically complex sun simulators under almost natural irradiance and climatic conditions. as observed, uv-b radiation increased herb and ... | 2013 | 24044900 |
| antiproliferative, cell-cycle dysregulation effects of novel asiatic acid derivatives on human non-small cell lung cancer cells. | asiatic acid (aa) is a pentacyclic triterpene in centella asiatica known to inhibit proliferation and induce apoptosis in several tumor cell lines. in the current study, we synthesized five aa derivatives and examined their inhibitory activities on growth in non-small cell lung cancer cell lines, a549 and pc9/g. four derivatives were found to have stronger cell growth inhibitory activity than aa. among them, compound a-3 showed the most significant antiproliferative effects on tumor. growth of a ... | 2013 | 23924616 |
| neuritogenic effect of standardized extract of centella asiatica eca233 on human neuroblastoma cells. | in order to gain insight into neuroprotective effects of eca 233, a standardized extract of centella asiatica, previously demonstrated in animal models of memory impairment induced by transient global ischemia or intracerebroventricular injection of β-amyloid, the effect of eca 233 on neurite outgrowth of human imr-32 neuroblastoma cell line was investigated. | 2013 | 23915016 |
| neuroprotective effects of madecassoside in early stage of parkinson's disease induced by mptp in rats. | in this study, we investigated the neuroprotective effects of madecassoside, isolated from the chinese medicinal herb centella asiatica, in the rat model of early phase of parkinsonism. during intragastric administrations of madecassoside for 7 days, the rats were injected with mptp on the 7th day. and for the following 14 days, madecassoside were also administered. on the 14th day, the behavioral tests were assessed after 1h of administration. and then, the rats were sacrificed, substantia nigr ... | 2013 | 23876367 |
| effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy. | centella asiatica has been used to treat kidney diseases in chinese traditional medicine. asiaticoside (an extraction of c. asiatica) exerts a variety of pharmacological effects including immunomodulatory and anti-inflammatory functions. however, the mechanism of asiaticoside in the treatment of renal diseases remains largely unknown. this study investigated the molecular mechanism of asiaticoside in treating adriamycin-induced nephropathy of rats. | 2013 | 23871990 |
| retention of nutrients in green leafy vegetables on dehydration. | the objective of the study was to investigate the influence of dehydration on nutrient composition of amaranthus gangeticus, chenopodium album, centella asiatica, amaranthus tricolor and trigonella foenum graecum. the green leafy vegetables (glv) were steam blanched for 5 min after pretreatment and dried in an oven at 60 °c for 10-12 h. the fresh and dehydrated samples were analyzed for selected proximate constituents, vitamins, minerals, antinutrients and dialyzable minerals. dehydration seems ... | 2013 | 24425998 |
| [analysis on preparation and characterization of asiaticoside-loaded flexible nanoliposomes]. | asiaticoside is a compound extracted from traditional chinese medicine centella asiatica, and mainly used in wound healing and scar repair in clinical, with notable efficacy. however, its poor transdermal absorption and short action time restrict its wide application. in this experiment, the reserve-phase-extrusion-lyophilization method was conducted to prepare the lyophilized asiaticoside-loaded flexible nanoliposomes (lafl). its characteristics including electron microscope structure, particle ... | 2013 | 24422392 |
| evaluation of analgesic and anti-inflammatory activity of chloroform and methanol extracts of centella asiatica linn. | a variety of active constituents with wide range of pharmacological actions have been reported with centella asiatica. the present study was undertaken to assess analgesic and anti-inflammatory properties of its leaf extracts. dried leaves were defatted with petroleum ether and extracted with chloroform and methanol. both chloroform and methanol extracts were evaluated for analgesic activity through tail clip, tail flick, tail immersion, and writhing assay tests at doses of 50, 100, and 200 mg/k ... | 2013 | 24369507 |
| barium levels in soils and centella asiatica. | in this study, centella asiatica and surface soils were collected from 12 sampling sites in peninsular malaysia, and the barium (ba) concentrations were determined. the ba concentration [μg/g dry weight (dw)] was 63.72 to 382.01 μg/g in soils while in c. asiatica, ba concentrations ranged from 5.05 to 21.88 μg/g for roots, 3.31 to 11.22 μg/g for leaves and 2.37 to 6.14 μg/g for stems. in c. asiatica, ba accumulation was found to be the highest in roots followed by leaves and stems. the correlati ... | 2013 | 24575242 |
| anti-diabetic effect of a combination of andrographolide-enriched extract of andrographis paniculata (burm f.) nees and asiaticoside-enriched extract of centella asiatica l. in high fructose-fat fed rats. | traditionally, a combination of medicinal plants is commonly used for lowering blood glucose in diabetic patients in order to provide additional benefits of the single drug. a. paniculata and c. asiatica are two traditional medicines form south asian and southeast asain countries consumed by people for treating daibates mellitus and its complications. hyperglycemia in the rats was stimulated by high fructose-fat diet that consists of 36% fructose, 15% lard, and 5% egg yolks in 0.36 g/200 g body ... | 2013 | 24579376 |
| merremia emarginata (burm. f.) hall. f.: a substituted market source for centella asiatica (l.) urban: an observation from salem district, tamil nadu. | 2013 | 25284949 | |
| antioxidant synergism between ethanolic centella asiatica extracts and α-tocopherol in model systems. | the synergistic antioxidant effects of ethanolic extracts of centella asiatica (ce), and α-tocopherol have been studied. the types of interactions exhibited by ce and α-tocopherol combined at different ratios were measured using three assays: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (abts) radical-scavenging capacity, the β-carotene bleaching system and liposome peroxidation assays. fixed-fraction isobolographic analysis was used to detect any inducement of the ant ... | 2013 | 23411234 |
| homology modeling and docking studies on oxidosqualene cyclases associated with primary and secondary metabolism of centella asiatica. | centella asiatica is a well-known medicinal plant, produces large amount of triterpenoid saponins, collectively known as centelloids, with a wide-spectrum of pharmacological applications. various strategies have been developed for the production of plant secondary metabolites in cell and tissue cultures; one of these is modular metabolic engineering, in which one of the competitive metabolic pathways is selectively suppressed to channelize precursor molecules for the production of desired molecu ... | 2013 | 25247142 |
| use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. randomized, double-blind, controlled trial. | few studies have tested the efficacy of commercially available cosmetic products for preventing striae gravidarum. therefore, the objective of this study was to evaluate efficacy on prevention of striae gravidarum using a specific anti-stretch mark cream containing hydroxyprolisilane-c, rosehip oil, centella asiatica triterpenes and vitamin e. a randomized, double-blind, placebo-controlled trial was conducted between november 2009 and april 2011. pregnant women were included and classified as tr ... | 2013 | 23237514 |
| mitoprotective effect of centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism. | role of mitochondrial dysfunction and oxidative stress has been well documented in various cognitive-related disorders such as alzheimer's disease. aluminum is a neurotoxic metal that may be involved in the progression of neurodegenerative processes. the antioxidant and memory enhancing effects of centella asiatica (ca) are well known in the last few decades. therefore, the present study has been designed to explore the neuroprotective effect of ca on chronic aluminum exposure induced mitochondr ... | 2013 | 23224641 |
| efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats. | asiatic acid (aa), a triterpenoid derivative of centella asiatica, has shown significant biological effects of antioxidant and anti-inflammatory activities. aim of this investigation was to evaluate the antihyperglycemic effect of aa on the activities of hepatic enzymes of carbohydrate metabolism in streptozotocin (stz)-induced diabetic rats. to induce diabetes mellitus, rats were injected with streptozotocin intraperitoneally at a single dose of 40 mg/kg b.w. diabetic rats showed significant (p ... | 2013 | 23102509 |
| antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1. | asiaticoside (as), a triterpenoid isolated from centella asiatica, has been found to exhibit antioxidant and anti-inflammatory activities in several experimental animal models. however, the underlying mechanisms remain elusive. in this study, we provide experimental evidences that as dose-dependently inhibited lipopolysaccharide (lps)-induced fever and inflammatory response, including serum tumor necrosis factor (tnf)-α and interleukin (il)-6 production, liver myeloperoxidase (mpo) activity, bra ... | 2013 | 22972613 |
| centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. | centella asiatica has been used as psychoactive and antioxidant herbal medicine since ancient time. the present study was design to evaluate the preventive role of ethanolic extract of c. asiatica in middle cerebral artery occlusion (mcao) in rats. male wistar rats were gavaged orally with c. asiatica extract (100, 200 and 300 mg/kg body weight once daily) for 21 days and thereafter subjected to right mcao for 2 h followed by 22-h reperfusion. brain injury was evaluated by 2,3,5-triphenyltetrazo ... | 2013 | 22864972 |
| scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis. | rheumatoid arthritis (ra) is a chronic, systemic autoimmune inflammatory disorder that causes permanent disability and mortality to approximately 1 to 100 people in the world. patients with ra not only suffer from pain, stiffness, swelling, and loss of function in their joints, but also have a higher risk of cardiovascular disease and lymphoma. typically prescribed medications, including pain-relieving drugs, nonsteroidal anti-inflammatory drugs (nsaid), and disease-modifying antirheumatic drugs ... | 2013 | 22700248 |
| an investigation of arsenic contamination in peninsular malaysia based on centella asiatica and soil samples. | the first objective of this study was to provide data of arsenic (as) levels in peninsular malaysia based on soil samples and accumulation of as in centella asiatica collected from 12 sampling sites in peninsular malaysia. the second objective was to assess the accumulation of as in transplanted c. asiatica between control and semi-polluted or polluted sites. four sites were selected which were upm (clean site), balakong (semi-polluted site), seri kembangan (semi-polluted site) and juru (pollute ... | 2013 | 22821327 |
| asiaticoside induces type i collagen synthesis and osteogenic differentiation in human periodontal ligament cells. | asiaticoside, an active ingredient extracted from centella asiatica, has been widely used to promote wound healing. in this study, the effects of asiaticoside on proliferation, protein synthesis, and osteogenic differentiation in human periodontal ligament cells (hpdls) were investigated. hpdls were treated with asiaticoside at concentrations of 25, 50, and 100 µg/ml. cell number was determined by mtt assay. the mrna expression was analyzed by reverse transcription-polymerase chain reaction. wes ... | 2013 | 22628285 |
| a new method for preparing pentacyclic triterpene rich centella asiatica extracts. | this study evaluated microwave-assisted extraction (mae) for four pentacyclic triterpenes as well as developed a method for preparing a pentacyclic triterpenene rich extract from centella asiatica. mae was capable of increasing the yield of the pentacyclic triterpenes up to twice that produced by the heat reflux method, and it was also much less time consuming. the optimal conditions of mae employed were extraction with absolute ethanol as solvent, an irradiation power of 600 w, at 75°c, four ir ... | 2013 | 22577972 |
| centella asiatica extract improves behavioral deficits in a mouse model of alzheimer's disease: investigation of a possible mechanism of action. | centella asiatica (ca), commonly named gotu kola, is an ayurvedic herb used to enhance memory and nerve function. to investigate the potential use of ca in alzheimer's disease (ad), we examined the effects of a water extract of ca (gkw) in the tg2576 mouse, a murine model of ad with high β-amyloid burden. orally administered gkw attenuated β-amyloid-associated behavioral abnormalities in these mice. in vitro, gkw protected sh-sy5y cells and mc65 human neuroblastoma cells from toxicity induced by ... | 2012 | 22506133 |