Publications

transfer of streptococcus adjacens and streptococcus defectivus to abiotrophia gen. nov. as abiotrophia adiacens comb. nov. and abiotrophia defectiva comb. nov., respectively.	we performed this study to determine the 16s rrna sequences of the type strains of streptococcus adjacens and streptococcus defectivus and to calculate the phylogenetic distances between these two nutritionally variant streptococci (nvs) and other members of the genus streptococcus. s. adjacens and s. defectivus belonged to one cluster, but this cluster was not closely related to other streptococcal species. a comparative analysis of the sequences of these organisms and other low-g+c-content gra ...	1995	7547302
identification of the surface component of streptococcus defectivus that mediates extracellular matrix adherence.	bacterial attachment to host tissue is considered to be a crucial primary step in pathogen infection. previous studies have shown that streptococcus defectivus adheres specifically to cell-secreted extracellular matrix (ecm). though generally not exposed in vivo, this host tissue is exposed at endothelial cell junctions and sites of tissue injury. in this report, we identify a ca. 200-kda surface protein of s. defectivus involved in ecm adherence. nitrous acid-derived mutant strains that were un ...	1993	8225574
inverse correlation in nutritionally variant streptococci between the production of bacteriolytic activity and sensitivity to a streptococcus pyogenes bacteriocinlike inhibitory substance.	nineteen strains of nutritionally variant streptococci (nvs) were tested for bacteriolytic activity and for their production of and sensitivity to streptococcal bacteriocinlike inhibitory substances (blis). none appeared to produce blis. an inverse relationship was found between the sensitivity to blis and the production of bacteriolytic activity against micrococcus luteus. all but one of the 14 streptococcus defectivus isolates were sensitive to the blis of s. pyogenes p5, and these isolates we ...	1991	1890190
evaluation of the immune response in protection against experimental streptococcus defectivus endocarditis.	immune protection from endocarditis caused by streptococcus defectivus was examined by using a rabbit model. previously we had demonstrated that immunization with nutritionally variant streptococci (nvs, now referred to as streptococcus, species defectivus and adjacens) protected rabbits against endocarditis when they were challenged with the homologous strain. however, when high-titer immune globulin was transferred to nonimmunized rabbits, no protection was achieved. in the present study, immu ...	1991	2019795
analysis of adherence of streptococcus defectivus and endocarditis-associated streptococci to extracellular matrix.	pathogenesis of nutritionally variant streptococcal (nvs) endocarditis initiates with bacterial attachment to and colonization of the damaged heart valve surface. underlying extracellular matrix (ecm) exposed to the environment during damage to cardiac endothelium provides additional receptors that could be involved in bacterial adherence. the ability of nvs and endocarditis-associated streptococci to bind ecm was investigated by using an enzyme-linked immunosorbent assay system that incorporate ...	1991	1997435
intraspecies variations in nutritionally variant streptococci: rrna gene restriction patterns of streptococcus defectivus and streptococcus adjacens.	the rrna gene restriction patterns of two species of nutritionally variant streptococci, streptococcus defectivus and streptococcus adjacens, were determined, and the results were compared with the electrophoretic migration profiles of penicillin-binding proteins. reference strains belonging to various streptococcal species were used as controls. our results correlated with the results of dna-dna hybridization experiments and confirmed the delineation of these two species. moreover, they demonst ...	1991	1720653