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probiotics protect mice from cocrmo particles-induced osteolysis.wear particle-induced inflammatory osteolysis is the primary cause of aseptic loosening, which is the most common reason for total hip arthroplasty (tha) failure in the med- and long term. recent studies have suggested an important role of gut microbiota (gm) in modulating the host metabolism and immune system, leading to alterations in bone mass. probiotic bacteria administered in adequate amounts can alter the composition of gm and confer health benefits to the host. given the inflammatory ost ...201728794630
chemometric evaluation of the volatile profile of probiotic melon and probiotic cashew juice.the aim of this study was to evaluate the influence of the lactic acid fermentation on volatile compounds of melon and cashew apple juices. the effect of the fermentation processing on the volatile profile of probiotic juices was assessed by hs-spme/gc-ms coupled to chemometrics with 67.9% and 81.0% of the variance in the first principal component for melon and cashew juices, respectively. the lactobacillus casei fermentation imparted a reduction of ethyl butanoate, ethyl-2-methylbutirate, and e ...201728784506
lactobacillus casei ccfm419 attenuates type 2 diabetes via a gut microbiota dependent mechanism.probiotics, as dietary supplements, transmit their major effects through the regulation of gut microbiota. according to a previous study, one possible mechanism of lactobacillus casei ccfm419 protection against diabetes may involve gut flora. to test this hypothesis, high fat and streptozotocin-induced c57bl/6j mice were fed l. casei ccfm419 at 10(8), 10(9), and 10(10) colony forming units (cfu). compared to untreated mice, 10(9) cfu of l. casei ccfm419 attenuated several symptoms of diabetes, i ...201728782784
a fast pcr-based method for the characterization of prophage profiles in strains of the lactobacillus casei group.lysogeny is widespread among lactobacillus strains of the casei group (l. casei, l. paracasei and l. rhamnosus), and prophages account for most strain-specific dna. numerous pcr based methods have been developed to detect free phages of lactic acid bacteria, but they do not take in consideration prophages. in this study, a new pcr method for the detection of lysogeny was developed using genome sequences of l. casei group strains (including bl23) and bacteriophages. nine pairs of primers were des ...201728757387
effects of intake of lactobacillus casei subsp. casei 327 on skin conditions: a randomized, double-blind, placebo-controlled, parallel-group study in women.lactic acid bacteria are gut flora that play key roles in intestinal homeostasis, which may affect a variety of physiological functions. our preliminary double-blind, placebo-controlled, parallel-group trials have suggested that intake of heat-killed lactobacillus casei subsp. casei 327 (designated l. k-1) is effective for improving skin conditions. the aim of this study was to confirm the effect of l. k-1 intake in a randomized, double-blind, placebo-controlled, parallel-group study in healthy ...201728748132
metabolic gene-targeted monitoring of non-starter lactic acid bacteria during cheese ripening.long ripened cheeses, such as grana padano (gp), a protected designation of origin (pdo) italian cheese, harbor a viable microbiota mainly composed of non-starter lactic acid bacteria (nslab), which contribute to the final characteristics of cheese. the nslab species lactobacillus rhamnosus, lb. casei and lb. paracasei are frequently found in gp, and form a closely related taxonomic group (lb. casei group), making it difficult to distinguish the three species through 16s rrna sequencing. spxb, a ...201728735145
the effect of probiotic lactobacillus casei shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial.knee osteoarthritis (oa) treatment is challenging due to inefficacy and adverse effects of current medications. probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including oa. we aimed to investigate the effect of probiotic lactobacillus casei shirota (lcs) on patients with knee oa. 537 patients with knee oa were enrolled in this double-blind, placebo-controlled trial, who were randomised to receive ski ...201728726510
effective identification of lactobacillus casei group species: genome-based selection of the gene mutl as the target of a novel multiplex pcr assay.lactobacillus casei,lactobacillus paracasei and lactobacillusrhamnosus form a closely related taxonomic group (the l. casei group) within the facultatively heterofermentative lactobacilli. strains of these species have been used for a long time as probiotics in a wide range of products, and they represent the dominant species of nonstarter lactic acid bacteria in ripened cheeses, where they contribute to flavour development. the close genetic relationship among those species, as well as the simi ...201728721852
characterization of candidate probionts isolated from human breast milk.this study was designed to isolate and identify the potential probionts present in 32 healthy mothers' breast milk. microbial culture media and 16srrna sequencing were used to isolate and identify the bacteria and all isolates were analyzed for their antagonistic potential, resistance to acidic ph, bile salts and survival under simulated gastric and intestinal conditions. the colonization potential was further assessed based on adherence to human enterocyte-like caco-2 cell lines. the breast mil ...201728719350
strains of the lactobacillus casei group show diverse abilities for the production of flavor compounds in 2 model systems.cheese flavor development is directly connected to the metabolic activity of microorganisms used during its manufacture, and the selection of metabolically diverse strains represents a potential tool for the production of cheese with novel and distinct flavor characteristics. strains of lactobacillus have been proven to promote the development of important cheese flavor compounds. as cheese production and ripening are long-lasting and expensive, model systems have been developed with the purpose ...201728711258
high-quality draft genome sequence of lactobacillus casei strain z11, isolated from a human adult intestinal biopsy sample.several lactobacillus casei strains are used as probiotics. l. casei strain z11, isolated from a human colon biopsy sample, has been suggested as a probiotic candidate based on promising properties in vitro here, we present a 2.74-mbp high-quality draft genome sequence for this strain.201728705981
investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study.the aim of this study was to demonstrate the efficacy of synbiotic (lactobacillus casei, l. rhamnosus, l. plantarum, and bifidobacterium lactis and prebiotics [fiber, polydextrose, fructo-oligosaccharides, and galacto-oligosaccharides]) treatment in children with functional constipation.201728705786
direct and indirect measurements of enhanced phenolic bioavailability from litchi pericarp procyanidins by lactobacillus casei-01.litchi pericarp procyanidins (lpp) are dietary supplements with high antioxidant activity, but poor oral bioavailability and efficacy. lactobacillus casei (l. casei-01) can transform flavan-3-ols from litchi pericarp and increase their antioxidant ability; thus, l. casei-01 with lpp was administered to rats for four and eight weeks to study the effect of such a combination on metabolic parameters and on phase ii metabolism and detoxification pathways in the liver as an indirect measure for pheno ...201728702654
anxiogenic effects of a lactobacillus, inulin and the synbiotic on healthy juvenile rats.gut microbiota interventions, including probiotic and prebiotic use can alter behavior in adult animals and healthy volunteers. however, little is known about their effects in younger individuals. to investigate this, male sprague-dawley rats (post-natal day 21, pnd21) received lactobacillus casei 54-2-33 (10(4)cfu/ml), inulin as prebiotic (16mg/ml), or both together (synbiotic) via drinking water for 14days. control rats received water alone. open field (of) and elevated plus maze (epm) behavio ...201728694176
the viable but nonculturable state induction and genomic analyses of lactobacillus casei bm-lc14617, a beer-spoilage bacterium.this study aimed to investigate the viable but nonculturable (vbnc) state and genomic features of a beer-spoilage strain, lactobacillus caseibm-lc14617. induction on the vbnc state of l. casei strain bm-lc14617 was conducted by both low-temperature storage and continuous passage in beer, and formation of vbnc state was detected after 196 ± 3.3 days and 32 ± 1.6 subcultures, respectively. resuscitation of vbnc cells was successfully induced by addition of catalase, and culturable, vbnc, and resus ...201728685978
prophylactic effects of secretion metabolites of dairy lactobacilli through downregulation of erbb-2 and erbb-3 genes on colon cancer cells.colon cancer is one of the most prevalent cancers, and intestinal microbial community plays a pivotal role in colorectal tumor genesis. probiotics as live microorganisms may be able to exert an anticancer effect in colon cancer. the aim of this study was to isolate and identify lactobacillus spp. from traditional dairy products with probiotic properties and to investigate their anticancer effects through erbb-2 and erbb-3 gene expression in colon cancer cells. the isolated lactobacilli from yogu ...201728683007
ferrichrome identified from lactobacillus casei atcc334 induces apoptosis through its iron-binding site in gastric cancer cells.ferrichrome is known to be a siderophore, but it was recently identified as a tumor-suppressive molecule derived from lactobacillus casei atcc334 ( l. casei). in the present study, we investigated the effects of ferrichrome in gastric cancer cells. cell lines and xenograft models treated with ferrichrome demonstrated growth suppression. the expression levels of cleaved poly (adenosine diphosphate-ribose) polymerase, and cleaved caspase-9 were increased by ferrichrome treatment. although the tumo ...201728639907
effect of natural polymers on the survival of lactobacillus casei encapsulated in alginate microspheres.linseed and okra mucilages, the fungal exopolysaccharide botryosphaeran, and commercial fructo-oligosaccharides (fos) were used to microencapsulate lactobacillus casei lc-01 and l. casei bgp 93 in sodium alginate microspheres by the extrusion technique in calcium chloride. the addition of carbohydrate biopolymers from linseed, okra and the fungal exocellular (1 → 3)(1 → 6)-β-d-glucan, named botryosphaeran provided higher encapsulation efficiency (ee) (>93% and >86%) for l. casei lc 01 and l. cas ...201728618877
apple cider vinegar boosted immunomodulatory and health promoting effects of lactobacillus casei in common carp (cyprinus carpio).the present study was performed to investigate the immunomodulatory and health promoting effects of combined or singular administration of apple cider vinegar (acv) and lactobacillus casei in common carp (cyprinus carpio) diet. an 8-week feeding trial was designed with following treatments: control (basal diet), pro (contains 10(7) cfu g(-1)l. casei), lacv (contains 1% acv), hacv (contains 2% acv), pro + lacv (contains 10(7) cfu g(-1)l. casei plus 1% acv) and pro + hacv (contains 10(7) cfu g(-1) ...201728602743
notch4 signaling pathway in a kawasaki disease mouse model induced by lactobacillus casei cell wall extract.the present study aimed to explore the role of the notch4 signaling pathway in a mouse model of kawasaki disease (kd) induced by lactobacillus casei cell wall extract (lcwe). balb/c male mice (4-6 weeks old) were intraperitoneally injected with 500 µg lcwe in phosphate-buffered saline (pbs) or pbs alone (control group). at days 3, 7, 14 and 28, the numbers of circulating endothelial progenitor cells (epcs) in the peripheral blood and the expression of notch4 on the surface of epcs were detected. ...201728587423
echocardiographic evaluation of coronary abnormalities and cardiac function in a murine model of kawasaki disease using high-frequency ultrasound.murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in kawasaki disease (kd). this study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of kd with a high-frequency ultrasound system and to provide evidence for the preparation of the model of kd.201728584211
physicochemical characterization and antitumour activity of exopolysaccharides produced by lactobacillus casei sb27 from yak milk.two high molecular weight fractions (lw1 and lw2) of exopolysaccharides (epss) produced by lactobacillus casei sb27 were isolated from yak milk obtained from the gansu tibetan area of china. gc-ms, ftir spectroscopy, methylation analysis and fe-sem analysis were performed to elucidate the physicochemical characterization of these two fractions, and their in vitro antitumour activities were also evaluated. the molecular weights (mws) of lw1 and lw2 as determined by hpgpc were 25.10 and 12.34kda, ...201728578968
the performance of probiotic fermented sheep milk and ice cream sheep milk in inhibiting enamel mineral loss.the study aimed to evaluate the effects of two different sheep milk-based food matrices - fermented sheep milk and ice cream - with added probiotic bacteria (lactobacillus casei 431) on dental enamel subjected to an in vitro highly cariogenic challenge. sixty enamel blocks were selected and randomly allocated into five treatment groups (n=12): conventional fermented sheep milk (cfsm), probiotic fermented sheep milk (pfsm), conventional sheep milk ice cream (csmic), probiotic sheep milk ice cream ...201728578040
synbiotic fermentation for the co-production of lactic and lactobionic acids from residual dairy whey.besides its properties as an antioxidant, stabilizer or acidifier, lactobionic acid has emerged as a potential prebiotic compound, raising the possibility of being included together with the probiotic microorganism lactobacillus casei in novel functional fermented foods with synbiotic characteristics. their manufacturing strategy could benefit from the recently implemented microbial synthesis of lactobionic acid by the strong producer pseudomonas taetrolens, employing residual dairy whey as raw ...201728556559
synbiotic loaded chitosan-ca-alginate microparticles reduces inflammation in the tnbs model of rat colitis.new therapeutic strategies against inflammatory bowel disease (ibd) consider the usage of probiotics, prebiotics and synbiotics as beneficial for the intestinal microbial balance. limitations of such an approach are addressed into difference in survival, persistence, colonization and variable effects among different probiotic strains, lack in understanding of probiotic mechanisms of action, as well the complex etiology of ibd. the anti-inflammatory activity of lactobacillus casei 01 (l. casei 01 ...201728552770
preparation, structural characterisation and release study of novel hybrid microspheres entrapping nanoselenium, produced by green synthesis.the main goal of this study was to synthesise and characterise different formulations based on alginate and alginate/chitosan microspheres containing nanoselenium (nano-se) for controlled delivery applications. nanosize elemental selenium was produced by using probiotic yogurt bacteria (lactobacillus casei) in a fermentation procedure. the structural and morphological characterisation of the microspheres was performed by fourier transform infrared (ftir), x-ray diffraction (xrd) and scanning ele ...201728530192
intragastric administration of lactobacillus casei bl23 induces regulatory foxp3+rorγt+ t cells subset in mice.many studies have highlighted the immunomodulatory properties of the probiotic strain lactobacillus casei bl23. recently, we demonstrated the ability of this strain to modulate the th2-oriented immune response in a mouse model of cow's milk allergy based on the induction of a th17-biased immune response. the probiotic function of l. casei has been also linked to gut-microbiota modifications which could been potentially involved in the immune regulation; however, its precise mechanism of action r ...201728504580
effects of lactobacillus casei ccfm419 on insulin resistance and gut microbiota in type 2 diabetic mice.the antidiabetic effect of lactobacillus is increasingly recognized worldwide. in this research, the hypoglycemic activity of lactobacillus casei ccfm419 was investigated in mice with high-fat and low-dose streptozotocin induced type 2 diabetes. oral l. casei ccfm419 administration favourably regulated blood glucose balance, increased glucose tolerance and protected islets in the diabetic mice, accompanied by an improvement in lipid metabolism. the homeostasis model of insulin resistance, insuli ...201728504567
microbial amensalism in lactobacillus casei and pseudomonas taetrolens mixed culture.pseudomonas taetrolens has recently been revealed as an effective microbial producer of lactobionic acid from carbohydrates contained in dairy byproducts. in terms of food industrial applications, the implementation of lactobionic acid biosynthesis coupled with the classic bacterial production of lactic acid appears an important goal. this research paper studies the simultaneous fermentation of residual cheese whey by p. taetrolens and lactobacillus casei to co-produce lactic and lactobionic aci ...201728451809
beneficial effects of lactobacillus casei strain shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial.the present study examined whether lactobacillus casei strain shirota (lcs) improves sleep quality under psychological stress. a double-blind, placebo-controlled trial was conducted in healthy 4(th) year medical students exposed to academic examination stress. the trial was repeated over two consecutive years in different groups of students, and the data were pooled. for 8 weeks prior to and 3 weeks after a national standardised examination, a total of 48 and 46 subjects received a daily dose of ...201728443383
complete genome sequence of lactobacillus casei lc5, a potential probiotics for atopic dermatitis. 201728439274
characterization of the binding capacity of mercurial species in lactobacillus strains.metal sequestration by bacteria has been proposed as a strategy to counteract metal contamination in foodstuffs. lactobacilli can interact with metals, although studies with important foodborne metals such as inorganic [hg(ii)] or organic (ch3 hg) mercury are lacking. lactobacilli were evaluated for their potential to bind these contaminants and the nature of the interaction was assessed by the use of metal competitors, chemical and enzymatical treatments, and mutants affected in the cell wall s ...201728423187
lactobacillus casei dg and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome.the evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (pi-ibs) is convincing. lactobacillus spp. positively affect ibs symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. the aim of the study is to evaluate the role of lactobacillus casei dg (lc-dg) and its postbiotic (pb) in modulating the inflammatory/immune-response in pi-ibs in an ex-vivo organ culture model.201728410580
il-1 inhibition may have an important role in treating refractory kawasaki disease.kawasaki disease (kd) is an acute inflammatory vasculitis occurring in young children before 5 years and representing at this age, the main cause of acquired heart disease. a single infusion of 2 g/kg of intravenous immunoglobulins along with aspirin has reduced the frequency of coronary artery aneurysms from 25 to 5%. however, 10-20% of patients do not respond to standard treatment and have an increased risk of cardiac complications and death. the development of more potent therapeutic approach ...201728400731
natural lactic acid bacteria population of tropical grasses and their fermentation factor analysis of silage prepared with cellulase and inoculant.natural lactic acid bacteria (lab) populations in tropical grasses and their fermentation characteristics on silage prepared with cellulase enzyme and lab inoculants were studied. a commercial inoculant lactobacillus plantarum chikuso 1 (ch), a local selected strain lactobacillus casei th14 (th14), and 2 cellulases, acremonium cellulase (ac) and maicelase (mc; meiji seika pharma co. ltd., tokyo, japan), were used as additives to silage preparation with fresh and wilted (6 h) guinea grass and nap ...201627743669
characterization of extracellular yeast peptide factors and their stress-protective effect on probiotic lactic acid bacteria.protective effect of the extracellular peptide fraction (reactivating factors, rf) produced by yeasts of various taxonomic groups (saccharomyces cerevisiae, kluyveromyces lactis, candida utilis, and yarrowia li- polytica) on probiotic lactic acid bacteria (lab) lactobacillus casei, l. acidophilus,'and l. reuteri under bile salt (bs)-induced stress was shown. rf of all yeasts were shown to be of peptide nature; the active component of the s. cerevisiae rf was identified as a combination of low-mo ...201628853771
probiotic lactobacillus casei zhang reduces pro-inflammatory cytokine production and hepatic inflammation in a rat model of acute liver failure.in this study, we sought to find the effects and mechanisms of probiotic lactobacillus casei zhang (l. casei zhang) on the pro-inflammatory cytokine production and hepatic inflammatory response in a rat model of acute liver failure induced by lipopolysaccharide (lps) and d-galactosamine (galn).201625893720
lactobacillus casei stimulates phase-ii detoxification system and rescues malathion-induced physiological impairments in caenorhabditis elegans.malathion, an organophosphorus insecticide, is renowned for its inhibitory action on acetylcholinesterase (ache) enzyme that eventually leads to widespread disturbance in the normal physiological and behavioral activities of any organism. lactic acid bacteria (lab) are still an underexploited and inexhaustible source of significant pharmaceutical thrust. in the present study, caenorhabditis elegans was employed to identify and characterize the indigenous lab isolated from different traditional f ...201626297616
modulation of lactobacillus casei bacteriophage a2 lytic/lysogenic cycles by binding of gp25 to the early lytic mrna.the genetic switch of lactobacillus casei bacteriophage a2 is regulated by the ci protein, which represses the early lytic promoter pr and cro that abolishes expression from the lysogenic promoter pl . lysogens contain equivalent ci and cro-gp25 mrna concentrations, i.e., ci only partially represses p(r), predicting a lytic cycle dominance. however, a2 generates stable lysogens. this may be due to gp25 binding to the cro-gp25 mrna between the ribosomal binding site and the cro start codon, which ...201626417647
efficacy of lactobacillus casei shirota for patients with irritable bowel syndrome.meta-analyses point to a modest but significant effect of probiotics on symptoms in irritable bowel syndrome (ibs). we aimed to assess the effect of the probiotic lactobacillus casei shirota (lcs) on symptoms and quality of life in ibs patients in a randomized, double-blind, placebo-controlled intervention study.201626469356
effect of milk fermentation by kefir grains and selected single strains of lactic acid bacteria on the survival of mycobacterium bovis bcg.mycobacterium bovis that causes bovine tuberculosis (btb) can be transmitted to humans thought consumption of raw and raw fermented milk products from diseased animals. lactic acid bacteria (lab) used in popular traditional milk products in africa produce anti-microbial compounds that inhibit some pathogenic and spoilage bacteria. m. bovis bcg is an attenuated non-pathogenic vaccine strain of m. bovis and the aim of the study was to determine the effect of the fermentation process on the surviva ...201626544204
manufacture of probiotic minas frescal cheese with lactobacillus casei zhang.in this study, the addition of lactobacillus casei zhang in the manufacture of minas frescal cheese was investigated. minas frescal cheeses supplemented with probiotic bacteria (lactobacillus casei zhang) were produced by enzymatic coagulation and direct acidification and were subjected to physicochemical (ph, proteolysis, lactic acid, and acetic acid), microbiological (probiotic and lactic bacteria counts), and rheological analyses (uniaxial compression and creep test), instrumental color deter ...201626519974
catabolite responsive element deficiency of xyl operon resulting in carbon catabolite derepression in lactobacillus fermentum 1001.to explore the molecular mechanism of the carbon catabolite derepression in lactobacillus fermentum 1001 when this strain consumed xylose and glucose simultaneously.201626509553
effect of supplementation of fermented milk drink containing probiotic lactobacillus casei shirota on the concentrations of aflatoxin biomarkers among employees of universiti putra malaysia: a randomised, double-blind, cross-over, placebo-controlled study.human exposure to aflatoxin is through the diet, and probiotics are able to bind aflatoxin and prevent its absorption in the small intestine. this study aimed to determine the effectiveness of a fermented milk drink containing lactobacillus casei shirota (lcs) (probiotic drink) to prevent aflatoxin absorption and reduce serum aflatoxin b1-lysine adduct (afb1-lys) and urinary aflatoxin m1 concentrations. the present study was a randomised, double-blind, cross-over, placebo-controlled study with t ...201626490018
high-dose probiotic supplementation containing lactobacillus casei for 7 days does not enhance salivary antimicrobial protein responses to exertional heat stress compared with placebo.the study aimed to determine whether high-dose probiotic supplementation containing lactobacillus casei (l. casei) for 7 consecutive days enhances salivary antimicrobial protein (s-amp) responses to exertional-heat stress (ehs). eight endurance-trained male volunteers (age 26 ± 6 years, nude body mass 70.2 ± 8.8 kg, height 1.75 ± 0.05 m, vo2max 59 ± 5 ml·kg-1·min-1 [m ± sd]) completed a blinded randomized and counterbalanced crossover design. oral supplementation of the probiotic beverage (pro; ...201626479711
antidiabetic (type 2) effects of lactobacillus g15 and q14 in rats through regulation of intestinal permeability and microbiota.the antidiabetic effects of lactobacillus. paracasei subsp. paracasei g15 and lactobacillus. casei q14 in high fat diet and streptozotocin-induced type 2 diabetic (t2d) rats were evaluated in this study. the strains were separated from chinese traditional fermented dairy food. administration of g15 and q14 for 6 weeks significantly improved the glucose tolerance and reduced the hba1c levels in t2d rats. the probiotic treatment reduced the intestinal mucosal permeability and improved the epitheli ...201627713957
lactobacillus casei bl23 regulates treg and th17 t-cell populations and reduces dmh-associated colorectal cancer.chronic intestinal inflammation alters host physiology and could lead to colorectal cancer (crc). we have previously reported beneficial effects of the probiotic strain of lactobacillus casei bl23 in different murine models of intestinal inflammation. in addition, there is an emerging interest on the potential beneficial effects of probiotics to treat crc. we thus explored whether l. casei bl23 displays protective effects on crc.201626749362
short communication: protection of lyophilized milk starter lactobacillus casei zhang by glutathione.lyophilization is considered an effective way to preserve the activity of milk starters, such as lactic acid bacteria, in which proper protective agents play key roles. in this study, lactobacillus casei zhang, a probiotic bacterium applied as a milk starter in china, was used to investigate the effects of various cryoprotectants according to cell survival rate and physiological characteristics. the result showed a significant survival improvement to 86.6% when glutathione (gsh) was added as an ...201626723115
antimicrobial potential of papain chemomechanical agent on streptococcus mutans and lactobacillus casei followed by the use of self-etching adhesive systems.this study evaluated the antimicrobial effect of papain-based gel (papacárie/ p) followed by self-etching adhesive systems with mdpb monomer (clearfil protect bond/ pb) and without (clearfil se bond/ cl) on streptococcus mutans (sm) and lactobacillus casei (lc).201626696109
fermented milk containing lactobacillus casei strain shirota prevents the onset of physical symptoms in medical students under academic examination stress.this pilot study investigated the effects of the probiotic lactobacillus casei strain shirota (lcs) on psychological, physiological, and physical stress responses in medical students undertaking an authorised nationwide examination for promotion. in a double-blind, placebo-controlled trial, 24 and 23 healthy medical students consumed a fermented milk containing lcs and a placebo milk, respectively, once a day for 8 weeks until the day before the examination. psychophysical state, salivary cortis ...201626689231
labeling quality and molecular characterization studies of products containing lactobacillus spp. strains.the objective of the study was to characterize at species level by phenotypic and different molecular methods the strains of lactobacillus spp. used as constituents of five oral and four vaginal products. susceptibilities to representative antibiotics were evaluated. in addition, total viable counts at mid and 3 months to deadline of shelf life, in the different formulations and the presence of eventual contaminant microorganisms were investigated.in all oral products the molecular characterizat ...201626667227
the potential of the endolysin lysdb from lactobacillus delbrueckii phage for combating staphylococcus aureus during cheese manufacture from raw milk.phage endolysins have received increased attention in recent times as potential antibacterial agents and the biopreservatives in food production processes. staphylococcus aureus is one of the most common pathogens in bacterial food poisoning outbreaks. in this study, the endolysin lysdb, one of the two-component cell lysis cassette of lactobacillus delbrueckii phage phildb, was shown to possess a muramidase domain and catalytic sites with homology to chalaropsis-type lysozymes. peptidoglycan hyd ...201626621799
probiotic effect on calves infected with salmonella dublin: haematological parameters and serum biochemical profile.the aim of this study was to evaluate the effect of a probiotic/lactose inoculum on haematological and immunological parameters and renal and hepatic biochemical profiles before and during a salmonella dublin dspv 595t challenge in young calves. twenty eight calves, divided into a control and probiotic group were used. the probiotic group was supplemented with 100 g lactose/calf/d and 10(10) cfu/calf/d of each strain of a probiotic inoculum composed of lactobacillus casei dspv318t, lactobacillus ...201626615854
surface-displayed il-10 by recombinant lactobacillus plantarum reduces th1 responses of raw264.7 cells stimulated with poly(i:c) or lps.recently, poly-γ-glutamic acid synthetase a (pgsa) has been applied to display exogenous proteins on the surface of lactobacillus casei or lactococcus lactis, which results in a surfacedisplayed component of bacteria. however, the ability of carrying genes encoded by plasmids and the expression efficiency of recombinant bacteria can be somewhat affected by the longer gene length of pgsa (1,143 bp); therefore, a truncated gene, pgsa, was generated based on the characteristics of pgsa by computati ...201626608167
does short-term high dose probiotic supplementation containing lactobacillus casei attenuate exertional-heat stress induced endotoxaemia and cytokinaemia?the study aimed to determine if short-term high dose probiotic supplementation containing lactobacillus casei (l.casei) attenuates the commonly reported exertional-heat stress (ehs) induced endotoxinaemia and cytokinaemia. eight endurance trained male volunteers (mean± sd: age 26 ± 6 y, nude body mass 70.2 ± 8.8 kg, height 1.75 ± 0.05 m, vo2max 59 ± 5 ml·kg-1·min-1) completed a blinded randomized cross-over design, whereby oral ingestion of a commercially available probiotic beverage containing ...201626568577
peptide and amino acid metabolism is controlled by an ompr-family response regulator in lactobacillus casei.a lactobacillus casei bl23 strain defective in an ompr-family response regulator encoded by lcabl_18980 (prcr, rr11), showed enhanced proteolytic activity caused by overexpression of the gene encoding the proteinase prtp. transcriptomic analysis revealed that, in addition to prtp expression, prcr regulates genes encoding peptide and amino acid transporters, intracellular peptidases and amino acid biosynthetic pathways, among others. binding of prcr to twelve promoter regions of both upregulated ...201626711440
adhesions of extracellular surface-layer associated proteins in lactobacillus m5-l and q8-l.surface-layer associated proteins (slap) that envelop lactobacillus paracasei ssp. paracasei m5-l and lactobacillus casei q8-l cell surfaces are involved in the adherence of these strain to the human intestinal cell line ht-29. to further elucidate some of the properties of these proteins, we assessed the yields and expressions of slap under different incubation conditions. an efficient and selective extraction of slap was obtained when cells of lactobacillus were treated with 5 m licl at 37°c i ...201626709174
selection, characterisation and evaluation of potential probiotic lactobacillus spp. isolated from poultry droppings.aim of the present study was to characterise and evaluate probiotic potential of lactobacilli isolated from indigenous poultry. lactobacilli were isolated from poultry droppings and identified by genus specific polymerase chain reaction and 16s rrna gene sequencing. isolates were characterised in vitro by their ability to tolerate low ph and bile salts, phytase activity, antimicrobial activity, antibiotic susceptibility profile, and autoaggregation and coaggregation with poultry gut pathogens. i ...201626565086
evaluation of acrylamide-removing properties of two lactobacillus strains under simulated gastrointestinal conditions using a dynamic system.the aim of this study was to evaluate the capability of lactobacillus reuteri nrrl 14171 and lactobacillus casei shirota to remove dietary acrylamide (aa) under simulated gastrointestinal conditions using a dynamic system. the effects of different aa levels or bacteria concentration on toxin removal by lactobacillus strains were assessed. thereafter, aa-removing capability of bacteria strains under either fasting or postprandial simulated gastrointestinal conditions was evaluated. commercial pot ...201627393995
use of potential probiotic lactic acid bacteria (lab) biofilms for the control of listeria monocytogenes, salmonella typhimurium, and escherichia coli o157:h7 biofilms formation.use of probiotic biofilms can be an alternative approach for reducing the formation of pathogenic biofilms in food industries. the aims of this study were (i) to evaluate the probiotic properties of bacteriocinogenic (lactococcus lactis vb69, l. lactis vb94, lactobacillus sakei mbsa1, and lactobacillus curvatus mbsa3) and non-bacteriocinogenic (l. lactis 368, lactobacillus helveticus 354, lactobacillus casei 40, and weissela viridescens 113) lactic acid bacteria (lab) isolated from brazilian's f ...201627375584
the spxb gene as a target to identify lactobacillus casei group species in cheese.this study focused on the spxb gene, which encodes for pyruvate oxidase. the presence of spxb in the genome and its transcription could be a way to produce energy and allow bacterial growth during carbohydrate starvation. in addition, the activity of pyruvate oxidase, which produces hydrogen peroxide, could be a mechanism for interspecies competition. because this gene seems to provide advantages for the encoding species for adaptation in complex ecosystems, we studied spxb in a large set of che ...201627375244
lactobacillus casei as a biocatalyst for biofuel production.microbial fermentation of sugars from plant biomass to alcohols represents an alternative to petroleum-based fuels. the optimal biocatalyst for such fermentations needs to overcome hurdles such as high concentrations of alcohols and toxic compounds. lactic acid bacteria, especially lactobacilli, have high innate alcohol tolerance and are remarkably adaptive to harsh environments. this study assessed the potential of five lactobacillus casei strains as biocatalysts for alcohol production. l. case ...201627312380
bacterial succession on rat carcasses and applications for pmi estimation.abstract:201627301077
can the development and autolysis of lactic acid bacteria influence the cheese volatile fraction? the case of grana padano.in this study, the relationship between the dynamics of the growth and lysis of lactic acid bacteria in grana padano cheese and the formation of the volatile flavor compounds during cheese ripening was investigated. the microbial dynamics of grana padano cheeses that were produced in two different dairies were followed during ripening. the total and cultivable lactic microflora, community composition as determined by length heterogeneity-pcr (lh-pcr), and extent of bacterial lysis using an intra ...201627299670
the impact of lactobacillus casei on the composition of the cecal microbiota and innate immune system is strain specific.the probiotic function to impact human health is thought to be related to their ability to alter the composition of the gut microbiota and modulate the human innate immune system. the ability to function as a probiotic is believed to be strain specific. strains of lactobacillus casei are commonly utilized as probiotics that when consumed alter the composition of the gut microbiota and modulate the host immune response. l. casei strains are known to differ significantly in gene content. the objec ...201627244133
fermented milk containing lactobacillus casei strain shirota preserves the diversity of the gut microbiota and relieves abdominal dysfunction in healthy medical students exposed to academic stress.stress-induced abdominal dysfunction is an attractive target for probiotics. to investigate the effects of the probiotic lactobacillus casei strain shirota on abdominal dysfunction, a double-blind, placebo-controlled trial was conducted with healthy medical students undertaking an authorized nationwide examination for academic advancement. for 8 weeks, until the day before the examination, 23 and 24 subjects consumed an l. casei strain shirota-fermented milk and a placebo milk daily, respectivel ...201627208120
multilocus sequence typing of lactobacillus casei isolates from naturally fermented foods in china and mongolia.lactobacillus casei is a lactic acid bacterium used in manufacturing of many fermented food products. to investigate the genetic diversity and population biology of this food-related bacterium, 224 lb. casei isolates and 5 reference isolates were examined by multilocus sequence typing (mlst). among them, 224 lb. casei isolates were isolated from homemade fermented foods, including naturally fermented dairy products, acidic gruel, and sichuan pickles from 38 different regions in china and mongoli ...201627179867
draft genome sequence of the respiration-competent strain lactobacillus casei n87.lactobacillus casei is used as a starter, adjunct, and/or probiotic culture in the production of fermented and functional foods. here, we report the draft genome sequence of the respiration-competent strain l. casei n87, isolated from infant feces. this genome information may be useful for the study of respiratory metabolism in lactic acid bacteria.201627151805
theoretical insight into the heat shock response (hsr) regulation in lactobacillus casei and l. rhamnosus.the understanding of the heat shock response (hsr) in lactobacilli from a regulatory point of view is still limited, though an increased knowledge on the regulation of this central stress response can lead to improvements in the exploitation of these health promoting microorganisms. therefore the aim of this in silico study, that is the first to be carried out for members of the lactobacillus genus, was predicting how hsr influences cell functions in the food associated and probiotic species lac ...201627142777
carbapenem-resistant lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption.lactobacillus sp. is a low virulence bacterium, which rarely causes infection in immunocompetent individuals and usually is considered a contaminant. normally this organism is susceptible to β-lactam antibiotics, yet resistant strains have been reported.201627142043
in vitro and in vivo assessment of angiotensin-converting enzyme (ace) inhibitory activity of fermented soybean milk by lactobacillus casei strains.angiotensin-converting enzyme (ace) inhibitory activity of fermented soybean milk (fsm) by lactobacillus casei strains in vitro was investigated in this study. effects of fermented soybean milk administration by gavage on systolic blood pressure and diastolic blood pressure was also evaluated in spontaneously hypertensive rats (shr) rats and wistar-kyoto (wky) rats. results showed that, cicc 20280 and cicc 23184 fsm showed high ace inhibitory activity in vitro test and ace inhibitory activity of ...201627139252
live and heat-killed probiotic lactobacillus casei lbs2 protects from experimental colitis through toll-like receptor 2-dependent induction of t-regulatory response.inflammatory bowel disease (ibd) is a group of inflammatory disorders of the intestine caused by dysregulated t-cell mediated immune response against commensal microflora. probiotics are reported as therapeutically effective against ibd. however, variable efficacy of the live probiotic strains, difference in survival and persistence in the gut between the strains and the lack of insight into the mechanisms of probiotic action limit optimal therapeutic efficacy. our aims were to evaluate the lact ...201627107798
antitumoural activity of a cytotoxic peptide of lactobacillus casei peptidoglycan and its interaction with mitochondrial-bound hexokinase.in a previous study, we reported the cytotoxic activity against various tumour cells of the peptidoglycan of lactobacillus casei. to isolate the most active components, we performed column-chromatography separation of the peptidoglycan complex and tested the related fractions for their cytotoxic activity. the most active fractions were then lyophilized and the residue was analysed by gas chromatography for its amino acid content and composition. on the basis of the known chemical formula of the ...201627101258
probiotics in critically ill children.gut microflora contribute greatly to immune and nutritive functions and act as a physical barrier against pathogenic organisms across the gut mucosa. critical illness disrupts the balance between host and gut microflora, facilitating colonization, overgrowth, and translocation of pathogens and microbial products across intestinal mucosal barrier and causing systemic inflammatory response syndrome and sepsis. commonly used probiotics, which have been developed from organisms that form gut microbi ...201627081478
the influence of probiotic lactobacillus casei in combination with prebiotic inulin on the antioxidant capacity of human plasma.the aim of the present study was to assess whether probiotic bacteria lactobacillus casei (4 × 10(8) cfu) influences the antioxidant properties of human plasma when combined with prebiotic inulin (400 mg). experiments were carried out on healthy volunteers (n = 32). volunteers were divided according to sex (16 male and 16 female) and randomly assigned to synbiotic and control groups. blood samples were collected before synbiotic supplementation and after 7 weeks, at the end of the study. catalas ...201627066188
screening sourdough samples for gliadin-degrading activity revealed lactobacillus casei strains able to individually metabolize the coeliac-disease-related 33-mer peptide.a selective culture medium containing acid-hydrolyzed gliadins as the sole nitrogen source was used in the search for sourdough-indigenous lactic acid bacteria (lab) with gliadin-metabolizing activity. twenty gliadin-degrading lab strains were isolated from 10 sourdoughs made in different ways and from different geographical regions. fifteen of the 20 isolated strains were identified as lactobacillus casei, a species usually reported as subdominant in sourdough populations. the other 5 gliadin-d ...201627021684
a phase trial of the oral lactobacillus casei vaccine polarizes th2 cell immunity against transmissible gastroenteritis coronavirus infection.transmissible gastroenteritis coronavirus (tgev) is a member of the genus coronavirus, family coronaviridae, order nidovirales. tgev is an enteropathogenic coronavirus that causes highly fatal acute diarrhoea in newborn pigs. an oral lactobacillus casei (l. casei) vaccine against anti-transmissible gastroenteritis virus developed in our laboratory was used to study mucosal immune responses. in this l. casei vaccine, repetitive peptides expressed by l. casei (specifically the mdp and tuftsin fusi ...201627020282
achieving high yield of lactic acid for antimicrobial characterization in cephalosporin-resistant lactobacillus by the co-expression of the phosphofructokinase and glucokinase.lactobacilli are universally recognized as probiotics that are widely used in the adjuvant treatment of inflammatory diseases, such as vaginitis and enteritis. with the overuse of antibiotics in recent years, the lactobacilli in the human body are killed, which could disrupt the microecological balance in the human body and affect health adversely. in this work, cephalosporin-resistant lactobacillus casei rl20 was obtained successfully from the feces of healthy volunteers, which possessed a stab ...201626975769
experimental and pathalogical study of pistacia atlantica, butyrate, lactobacillus casei and their combination on rat ulcerative colitis model.this study evaluated the effects of pistacia atlantica (p. atlantica), butyrate, lactobacillus casei (l. casei) and especially their combination therapy on 2,4,6-trinitrobenzene sulphonic acid (tnbs)-induced rat colitis model. rats were divided into seven groups. four groups received oral p. atlantica, butyrate, l. casei and the combination of three agents for 10 consecutive days. the remaining groups were negative and positive controls and a sham group. macroscopic and histopathological examina ...201626972417
intragastric injection of lactobacillus casei strain shirota suppressed spleen sympathetic activation by central corticotrophin-releasing factor or peripheral 2-deoxy-d-glucose in anesthetized rats.intragastric (ig) administration of probiotic strain lactobacillus casei shirota (lcs) decreases the sympathetic nerve outflow of anesthetized rats in a tissue-specific manner. in the present study, we examined the effects of ig administration of lcs on sympathetic activation induced by an intracerebroventricular (icv) injection of corticotrophin-releasing factor (crf) and an intravenous (iv) injection of 2-deoxy-d-glucose (2dg) or interleukin (il)-1β in urethane-anesthetized rats. the ig admini ...201626971699
draft genome sequence of lactobacillus casei dpc6800, an isolate with the potential to diversify flavor in cheese.lactobacillus casei is a nonstarter lactic acid bacterium commonly present in various types of cheeses. it is believed that strains of this species have a significant impact on the development of cheese flavor. the draft genome sequence of l. casei dpc6800, isolated from a semi-hard dutch cheese, is reported.201626941145
role of interleukin-1 signaling in a mouse model of kawasaki disease-associated abdominal aortic aneurysm.kawasaki disease (kd) is the most common cause of acquired cardiac disease in us children. in addition to coronary artery abnormalities and aneurysms, it can be associated with systemic arterial aneurysms. we evaluated the development of systemic arterial dilatation and aneurysms, including abdominal aortic aneurysm (aaa) in the lactobacillus casei cell-wall extract (lcwe)-induced kd vasculitis mouse model.201626941015
probiotic lactobacillus casei strain shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models.this study aimed to examine the effects of lactobacillus casei strain shirota (lcs) on gut-brain interactions under stressful conditions.201626896291
lactobacillus casei peritonitis in peritoneal dialysis: a rare case and literature review. 201626879492
valorisation of food waste via fungal hydrolysis and lactic acid fermentation with lactobacillus casei shirota.food waste recycling via fungal hydrolysis and lactic acid (la) fermentation has been investigated. hydrolysates derived from mixed food waste and bakery waste were rich in glucose (80.0-100.2gl(-1)), fructose (7.6gl(-1)) and free amino nitrogen (947-1081mgl(-1)). in the fermentation with lactobacillus casei shirota, 94.0gl(-1) and 82.6gl(-1) of la were produced with productivity of 2.61gl(-1)h(-1) and 2.50gl(-1)h(-1) for mixed food waste and bakery waste hydrolysate, respectively. the yield was ...201626873283
effect of curing salts and probiotic cultures on the evolution of flavor compounds in dry-fermented sausages during ripening.the effect of the concentration of curing salts, the nature of the probiotic culture (free or immobilized lactobacillus casei atcc 393 on wheat grains) and the ripening time on the generation of volatile compounds in probiotic dry-fermented sausages was investigated. samples were collected after 1, 28 and 71 days of ripening and subjected to spme gc/ms analysis. all factors affected significantly the concentration of all volatile compounds. noticeably, the content of esters, organic acids and to ...201626868585
effect of the association of maltodextrin and sucrose on the acidogenicity and adherence of cariogenic bacteria.the aim was to investigate the effect of maltodextrin and sucrose association on the acidogenic and adherence profiles of cariogenic bacteria.201626867225
formation of kokumi-enhancing γ-glutamyl dipeptides in parmesan cheese by means of γ-glutamyltransferase activity and stable isotope double-labeling studies.recently, γ-glutamyl dipeptides (γ-gps) were found to be responsible for the attractive kokumi flavor of parmesan cheese (pc). quantitation of γ-gps and their parent amino acids in 13-, 24-, and 30-month ripened pc samples by lc-ms/ms and stable isotope dilution analysis (sida), in-cheese (13)c-labeling studies, followed by analysis of the γ-glutamyl transferase (ggt) activity revealed γ-gps to be generated most efficiently after 24 months of ripening by a ggt-catalyzed transfer of the γ-glutamy ...201626866784
biological activity of japanese quince extract and its interactions with lipids, erythrocyte membrane, and human albumin.the aim of the study was to determine in vitro biological activity of fruit ethanol extract from chaenomeles speciosa (sweet) nakai (japanese quince, jq) and its important constituents (-)-epicatechin (ec) and chlorogenic acid (ca). the study also investigated the structural changes in phosphatidylcholine (pc) liposomes, dipalmitoylphosphatidylcholine liposomes, and erythrocyte membranes (rbc) induced by the extract. it was found that the extract effectively inhibits oxidation of rbc, induced by ...201626861057
intake of a fermented soymilk beverage containing moderate levels of isoflavone aglycones enhances bioavailability of isoflavones in healthy premenopausal japanese women: a double-blind, placebo-controlled, single-dose, crossover trial.this study aimed to investigate the bioavailability of serum isoflavones after the intake of soymilk fermented by lactobacillus casei strain shirota containing 32.5% isoflavone aglycones (fsm) or placebo soymilk containing no isoflavone aglycones (sm). in a double-blind, placebo-controlled, single-dose, crossover trial, 7 healthy premenopausal japanese women (mean age: 35.3 ± 11.0) consumed fsm or sm on day 1 and crossed over to the other soymilk after a 6-day washout period. serum isoflavones i ...201626858926
binding and detoxification of chlorpyrifos by lactic acid bacteria on rice straw silage fermentation.this investigation examined the reduction of pesticide residues on straw inoculated with lactic acid bacteria (lab) during ensiling. lactobacillus casei wys3 was isolated from rice straw that contained pesticide residues. non-sterilized rice straw, which was inoculated with l. casei wys3, showed increased removal of chlorpyrifos after ensiling, compared with rice straw that was not inoculated with l. casei wys3 or sterilized rice straw. in pure culture, these strains can bind chlorpyrifos as ind ...201626852781
lactobacillus casei exerts anti-proliferative effects accompanied by apoptotic cell death and up-regulation of trail in colon carcinoma cells.probiotic microorganisms such as lactic acid bacteria (lab) exert a number of strain-specific health-promoting activities attributed to their immunomodulatory, anti-inflammatory and anti-carcinogenic properties. despite recent attention, our understanding of the biological processes involved in the beneficial effects of lab strains is still limited. to this end, the present study investigated the growth-inhibitory effects of lactobacillus casei atcc 393 against experimental colon cancer. adminis ...201626849051
enhancement of tumor-targeted delivery of bacteria with nitroglycerin involving augmentation of the epr effect.the use of bacteria, about 1 μm in size, is now becoming an attractive strategy for cancer treatment. solid tumors exhibit the enhanced permeability and retention (epr) effect for biocompatible macromolecules such as polymer-conjugated anticancer agents, liposomes, and micelles. this phenomenon permits tumor-selective delivery of such macromolecules. we report here that bacteria injected intravenously evidenced a property similar to that can of these macromolecules. bacteria that can accumulate ...201626846798
low intensity ultrasound increases the fermentation efficiency of lactobacillus casei subsp.casei attc 39392.l-lactic acid (l-la) is one of the microbial products with several applications and its production efficiency is so important. in the present study, we have been exploring application of low intensity ultrasound technology to improve the metabolic activity for l-lactic acid production by lactobacillus casei in different mediums. l-la, biomass production and substrate (protein) consumption were measured as parameters of fermentation yield. l-la and protein contents were determined using the titra ...201626836618
compromised lactobacillus helveticus starter activity in the presence of facultative heterofermentative lactobacillus casei dpc6987 results in atypical eye formation in swiss-type cheese.nonstarter lactic acid bacteria are commonly implicated in undesirable gas formation in several varieties, including cheddar, dutch-, and swiss-type cheeses, primarily due to their ability to ferment a wide variety of substrates. this effect can be magnified due to factors that detrimentally affect the composition or activity of starter bacteria, resulting in the presence of greater than normal amounts of fermentable carbohydrates and citrate. the objective of this study was to determine the pot ...201626805985
characterization and application of lactic acid bacteria for tropical silage preparation.strains th 14, th 21 and th 64 were isolated from tropical silages, namely corn stover, sugar cane top and rice straw, respectively, prepared in thailand. these strains were selected by low ph growth range and high lactic acid-producing ability, similar to some commercial inoculants. based on the analysis of 16s ribosomal rna gene sequence and dna-dna relatedness, strain th 14 was identified as lactobacillus casei, and strains th 21 and th 64 were identified as l. plantarum. strains th 14, th 21 ...201626799939
probiotic-derived ferrichrome inhibits colon cancer progression via jnk-mediated apoptosis.previous reports have suggested that some probiotics inhibit tumorigenesis and cancer progression. however, the molecules involved have not yet been identified. here, we show that the culture supernatant of lactobacillus casei atcc334 has a strong tumour-suppressive effect on colon cancer cells. using mass spectrometry, we identify ferrichrome as a tumour-suppressive molecule produced by l. casei atcc334. the tumour-suppressive effect of ferrichrome is greater than that of cisplatin and 5-fluoro ...201627507542
fermentation of de-oiled algal biomass by lactobacillus casei for production of lactic acid.de-oiled algal biomass (algal cake) generated as waste byproduct during algal biodiesel production is a promising fermentable substrate for co-production of value-added chemicals in biorefinery systems. we explored the ability of lactobacillus casei 12a to ferment algal cake for co-production of lactic acid. carbohydrate and amino acid availability were determined to be limiting nutritional requirements for growth and lactic acid production by l. casei. these nutritional requirements were effect ...201627503484
lactobacillus casei decreases organophosphorus pesticide diazinon cytotoxicity in human huvec cell line.exposure to diazinon can trigger acute and chronic toxicity and significantly induces dna damage and proapoptotic effects in different human cells. due to the significance of probiotic bacteria antitoxin effect, this study aimed to investigate the effect of lactobacillus casei on diazinon (dzn) cytotoxicity in human umbilical vein endothelial cells (huvec) in vitro.201627478782
characterization of prophages containing "evolved" dit/tal modules in the genome of lactobacillus casei bl23.lactic acid bacteria (lab) have many applications in food and industrial fermentations. prophage induction and generation of new virulent phages is a risk for the dairy industry. we identified three complete prophages (ple1, ple2, and ple3) in the genome of the well-studied probiotic strain lactobacillus casei bl23. all of them have mosaic architectures with homologous sequences to streptococcus, lactococcus, lactobacillus, and listeria phages or strains. using a combination of quantitative real ...201627448399
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