Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. | muchimangins are benzophenone-xanthone hybrid polyketides produced by securidaca longepedunculata. however, their biological activities have not been fully investigated, since they are minor constituents in this plant. to evaluate the possibility of muchimangins as antibacterial agent candidates, five muchimangin analogs were synthesized from 2,4,5-trimethoxydiphenyl methanol and the corresponding xanthones, by utilizing p-toluenesulfonic acid monohydrate for the brønsted acid-catalysis. the ant ... | 2017 | 28416134 |
| [effects of vacuum sealing drainage technique in acute and chronic suppurative tenosynovitis of hand]. | objective: to investigate the effects of vacuum sealing drainage technique in acute and chronic suppurative tenosynovitis of hand. methods: a total of 9 cases acute and chronic suppurative tenosynovitis patients from january 2013 to april 2015 in puai hospital affiliated to tongji medical college, huazhong university of science and technology were retrospectively reviewed. there were 6 males and 3 females, aging from 27 to 65 years, the average age was 55 years. there were 3 cases of index finge ... | 2017 | 28464581 |
| bacterial prevalence and antibiotic resistance in clinical isolates of diabetic foot ulcers in the northeast of tamaulipas, mexico. | diabetic foot ulcers (dfus) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation. the microbiological profile of dfus depends on the acute or chronic character of the wound. aerobic gram-positive cocci are the predominant organisms isolated from dfus. diabetic foot biopsies from patients admitted to the angiology and vascular surgery hospital of the northeast, in reynosa, tamaulipas from december 2011 to april 20 ... | 2017 | 28682727 |
| isolation and characterization of lactic acid bacteria from traditional pickles of himachal pradesh, india. | a total of 15 isolates of lactic acid bacteria (lab) were isolated from traditional pickles of rural and urban areas of himachal pradesh. these isolates were identified as enterococcus faecalis (7), lactobacillus plantarum (3), pediococcus pentosaceus (2), leuconostoc mesenteroides (1), lactococcus lactis (1) and enterococcus sp. (1) on the basis of morphological, biochemical and 16s rdna sequence analysis. all the labs produced exopolysaccharides, have antibiotic susceptibility, and possess act ... | 2017 | 28720951 |
| progress in definition, prevention and treatment of fungal infections in cystic fibrosis. | cystic fibrosis (cf) is a chronic lethal multi-system condition; however, most of the morbidity and mortality is dependent on the status of the respiratory system. progressive respiratory decline is mediated by chronic infection and inflammation, punctuated by important acute events known as pulmonary exacerbations which can lead to accelerated decline. the main bacterial species causing infections include pseudomonas aeruginosa, staphylococcus aureus, haemophilus influenzae and achromobacter xy ... | 2017 | 28762125 |
| air pollution exposure is associated with mrsa acquisition in young u.s. children with cystic fibrosis. | the role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (cf) population has not been well described. we recently demonstrated that chronic pm2.5 exposure is associated with an increased risk of initial pseudomonas aeruginosa acquisition in young children with cf. the purpose of this study was to determine whether pm2.5 exposure is a risk factor for acquisition of other respiratory pathogens in young children with cf. | 2017 | 28750627 |
| seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis. | seasonal variations are often observed for respiratory tract infections; however, limited information is available regarding seasonal patterns of acquisition of common cystic fibrosis (cf)-related respiratory pathogens. we previously reported differential seasonal acquisition of pseudomonas aeruginosa in young children with cf and no such variation for methicillin-susceptible staphylococcus aureus acquisition. the purpose of this study was to describe and compare the seasonal incidence of acquis ... | 2017 | 28599639 |
| comparison of a new matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform, asta microidsys, with bruker biotyper for species identification. | matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, with its accuracy and speed, is widely used for bacterial identification. the asta microidsys system (asta, korea) was recently developed for species identification. we compared its performance with that of bruker biotyper (bruker daltonics, germany). microbes were recovered from sputum, urine, and pus samples from patients admitted to a tertiary care hospital in korea from january to april 2016. matrix solution (α-cya ... | 2017 | 28840993 |
| application of maldi-tof ms fingerprinting as a quick tool for identification and clustering of foodborne pathogens isolated from food products. | foodborne pathogens can be associated with a wide variety of food products and it is very important to identify them to supply safe food and prevent foodborne infections. since traditional techniques are time-consuming and laborious, this study was designed for rapid identification and clustering of foodborne pathogens isolated from various restaurants in al-qassim region, kingdom of saudi arabia (ksa) using matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ... | 2017 | 28825446 |
| [distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015: results from a multicenter, retrospective study]. | objective: to describe the distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015 to provide reference for empirical anti-infection treatment. methods: pathogens were from hematology department of 26 tertiary hospitals in jiangsu province from 2014 to 2015. antimicrobial susceptibility testing was carried out according to a unified protocol using kirby-bauer method or agar dilution method. collection of drug susceptibility results and corresp ... | 2017 | 28810329 |
| efficacy of radiant catalytic ionization to reduce bacterial populations in air and on different surfaces. | air contamination by biological agents is often observed in medical or veterinary facilities and industrial plants. bioaerosols may sediment and pose the surface contamination. microorganisms present on them may become a source of infections among humans and food contamination. this study determined the use of oxidative gases, including ozone and peroxide, generated by the radiant catalytic ionization (rci) cell for the inactivation of acinetobacter baumannii, escherichia coli, enterococcus faec ... | 2017 | 28803189 |
| decontamination of hospital surfaces with multijet cold plasma: a method to enhance infection prevention and control? | objective to evaluate the efficacy of a multijet cold-plasma system and its efficacy in decontaminating 2 surfaces commonly found in hospitals design an in vitro study of common causes of healthcare-acquired infection methods log10 9 cultures of methicillin-resistant staphylococcus aureus, vancomycin-resistant enterococci, extended spectrum β-lactamase-producing escherichia coli, and acinetobacter baumannii were applied to 5-cm2 sections of stainless steel and mattress. human serum albumin (hsa) ... | 2017 | 28793943 |
| bioprospecting marine actinomycetes for multidrug-resistant pathogen control from rameswaram coastal area, tamil nadu, india. | a potent streptomyces bacillaris strain ram25c4 was isolated for controlling methicillin-resistant staphylococcus aureus and multidrug-resistant bacteria such as staphylococcus aureus, acinetobacter baumannii, and pseudomonas aeruginosa. a total of 131 actinomycetes were isolated from the rameswaram coastal region, tamil nadu, india. among 131 actinomycetes, maximum number of actinomycetes (55%) isolated at the distance of 3-6 m from seashore. out of 131 actinomycetes, 85% of the actinomycetes e ... | 2017 | 28785779 |
| biosynthesized silver nanoparticles: are they effective antimicrobials? | silver nanoparticles (agnps) are increasingly being used in medical applications. therefore, cost effective and green methods for generating agnps are required. | 2017 | 28767978 |
| antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study. | because of increasing antibiotic resistance, herbal teas are the most popular natural alternatives for the treatment of infectious diseases, and are currently gaining more importance. we examined the antimicrobial activities of 31 herbal teas both alone and in combination with antibiotics or antifungals against some standard and clinical isolates of pseudomonas aeruginosa, acinetobacter baumannii, escherichia coli, klebsiella pneumoniae, enterococcus faecalis, methicillin susceptible/resistant s ... | 2017 | 28761777 |
| stability of bacteriophages in burn wound care products. | bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. however, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. therefore, it is imperative to determine the counteraction of therapeutic phage preparations by burn wound care products before application in patients. five phages, representatives of two morphologi ... | 2017 | 28750102 |
| urea-derived graphitic carbon nitride (u-g-c3n4) films with highly enhanced antimicrobial and sporicidal activity. | in this manuscript, we describe the fabrication of photoactive biocidal or sporicidal films from urea-derived graphitic carbon nitride (u-g-c3n4). co-deposited films of u-g-c3n4 and escherichia coli o157:h7 (ic50=14.1±0.2mj) or staphylococcus aureus (methicillin resistant ic50=33.5±0.2mj, methicillin sensitive ic50=42.7±0.5mj) demonstrated significantly enhanced bactericidal behavior upon administration of visible radiation (400nm≤λ≤426nm). in all cases, complete eradication of the microbial sam ... | 2017 | 28675870 |
| impacts of pulsed electric field and heat treatment on quality and sensory properties and microbial inactivation of pomegranate juice. | synergistic effects of pulsed electric field+mild heat on quality properties of pomegranate juice were modeled using the best-fit multiple (non-) linear regression models with inactivation kinetics parameters of escherichia coli o157:h7 and staphylococcus aureus. no significant difference was detected between the control and the treated samples in terms of ph; °brix; total antioxidant capacity; total monomeric anthocyanin content; total ascorbic acid concentration; and the sensory properties of ... | 2017 | 28610446 |
| bad bacteria in acute appendicitis: rare but relevant. | bacterial infections are a factor for morbidity in patients with acute appendicitis (aa). the spreading of multidrug-resistant (mdr) bacteria is a significant problem in surgery, and the most relevant mdr pathogens are summarized as enterobacteriaceae, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterococci (eskape) bacteria. data regarding the species and distribution of bacteria in aa are available, but information about the resistances an ... | 2017 | 28710611 |
| the clinical and microbiological characteristics of infections in burn patients from the formosa fun coast dust explosion. | bloodstream infection is a leading cause of mortality among burn patients. this study aimed to evaluate the risk factors, causative pathogens, and the relationship between bloodstream infections and other infections among burn patients from the formosa fun coast dust explosion. | 2017 | 28705768 |
| development of silver nanoparticles loaded chitosan-alginate constructs with biomedical potentialities. | herein, a facile biosynthesis of silver nanoparticles (agnps) and agnps-loaded chitosan-alginate constructs with biomedical potentialities is reported. the uv-vis spectroscopic profile confirmed the synthesis of agnps using methanolic leaves extract of euphorbia helioscopia. the newly developed agnps were characterized using various analytical and imaging techniques including uv-vis and ft-ir spectroscopy, x-ray diffraction (xrd), scanning electron microscopy (sem), energy dispersive spectroscop ... | 2017 | 28705499 |
| antimicrobial susceptibility among gram-positive and gram-negative organisms collected from the latin american region between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial. | the in vitro activity of tigecycline and comparator agents was evaluated against gram-positive and gram-negative isolates collected in latin american centers between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial (t.e.s.t.) global surveillance study. | 2017 | 28701170 |
| investigation and analysis of the characteristics and drug sensitivity of bacteria in skin ulcer infections. | skin ulcer is a common type of disease affecting patients' health and quality of life, and bacterial infection increases the difficulty of its management. | 2017 | 28689800 |
| titanium surfaces immobilized with the major antimicrobial fragment fk-16 of human cathelicidin ll-37 are potent against multiple antibiotic-resistant bacteria. | infections on implanted medical devices are a challenging problem, especially when bacteria form difficult-to-treat biofilms. antimicrobial peptides are considered to be a solution due to their potency against antibiotic-resistant superbugs. previously, the authors' laboratory demonstrated the prevention of staphylococcal biofilm formation in an animal catheter model by injecting merecidin (formerly known as 17biphe2), a peptide engineered based on the only human cathelicidin. this study documen ... | 2017 | 28675109 |
| targeted surveillance and infection-related risk factors of nosocomial infection in patients after neurosurgical operation. | the purpose of this study was to investigate the risk factors of nosocomial infection in patients after neurosurgical operations, so as to provide reasonable, effective preventative measures in the future. a total of 1,600 patients with brain tumors, hydrocephalus, craniocerebral trauma and vascular disease treated in the neurosurgery room were chosen for targeted surveillance; and through analysis on the clinical data of patients, the incidence of nosocomial infection, the site of infection and ... | 2017 | 28671080 |
| nonribosomal peptide synthetase biosynthetic clusters of eskape pathogens. | covering: up to 2017.natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. a subset of natural products is produced by nonribosomal peptide synthetases (nrpss), a family of large, modular enzymes that function in an assembly line fashion. because of the pharmaceutical activity of many nrps products, much effort has gone in ... | 2017 | 28642945 |
| the anticancer peptide tat-rasgap317-326 exerts broad antimicrobial activity. | antibiotic resistance has become a major health issue. nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. therefore, there is an urgent need to develop new classes of antibiotics effective on multi-resistant nosocomial pathogenic bacteria. we have previously shown that a cell-permeable peptide derived from the p120 ras gtpase-activating protein (rasgap), called tat-rasgap317-326, induces cancer cell death, inhibits metastatic progression, and ... | 2017 | 28638371 |
| role of positively charged residues on the polar and non-polar faces of amphipathic α-helical antimicrobial peptides on specificity and selectivity for gram-negative pathogens. | we have designed de novo and synthesized eight 26-residue all d-conformation amphipathic α-helical cationic antimicrobial peptides (amps), four with "specificity determinants" which provide specificity for prokaryotic cells over eukaryotic cells and four amps without specificity determinants. the eight amps contain six positively charged lys residues on the polar face in four different arrangements to understand the role of these residues have on antimicrobial activity against 14 acinetobacter b ... | 2017 | 28636788 |
| identification of 1-((2,4-dichlorophenethyl)amino)-3-phenoxypropan-2-ol, a novel antibacterial compound active against persisters of pseudomonas aeruginosa. | antibiotics typically fail to completely eradicate a bacterial population, leaving a small fraction of transiently antibiotic-tolerant persister cells intact. persisters are therefore seen to be a major cause of treatment failure and greatly contribute to the recalcitrant nature of chronic infections. the current study focused on pseudomonas aeruginosa, a gram-negative pathogen belonging to the notorious eskape group of pathogens (enterococcus faecium, staphylococcus aureus, klebsiella pneumonia ... | 2017 | 28630188 |
| efficacy of (+)-lariciresinol to control bacterial growth of staphylococcus aureus and escherichia coli o157:h7. | this study was undertaken to assess the antibacterial potential of a polyphenolic compound (+)-lariciresinol isolated from rubia philippinensis against selected foodborne pathogens staphylococcus aureus kctc1621 and escherichia coli o157:h7. (+)-lariciresinol at the tested concentrations (250 μg/disk) evoked a significant antibacterial effect as a diameter of inhibition zones (12.1-14.9 mm) with minimum inhibitory concentration (mic), and minimum bactericidal concentration values of 125-250 and ... | 2017 | 28515721 |
| patterns of multi-drug resistant bacteria at first culture from patients admitted to a third level university hospital in calabria from 2011 to 2014: implications for empirical therapy and infection control. | surveillance of antimicrobial drug resistance is fundamental to guide empirical treatment. however, the european antimicrobial resistance surveillance network provides a general picture, which might not be applicable to clinical settings that are excluded from this survey. we evaluated resistance patterns of eskape isolates over a four-year period in a third level university hospital in the province of catanzaro (southern italy). in this retrospective study, we evaluated the frequency of eskape ... | 2017 | 28603227 |
| antimicrobial activity, toxicity and anti-inflammatory potential of methanolic extracts of four ethnomedicinal plant species from punjab, pakistan. | the plant species aristolochia indica (ai), melilotus indicus (mi), tribulus terrestris (tt) and cuscuta pedicellata (cp) are widely used in folk medicine in the villages around chowk azam, south punjab, pakistan. the aim of this study was to evaluate the antioxidant activity, phytochemical composition, and the antibacterial, antifungal, cytotoxic and anti-inflammatory potential of the four medicinal plants listed above. for cp stem, this study represents (to the best of our knowledge) the first ... | 2017 | 28595608 |
| prevalence of biofilm producing aerobic bacterial isolates in burn wound infections at a tertiary care hospital in northern india. | burn wounds frequently get infected due to a break in skin integrity and prolonged hospitalization. microbial flora originating from the patient's own flora colonize and infect the burn wounds. bacterial biofilms in particular are postulated as the culprit for the development of non-healing burn wounds by inducing chronic inflammation in these patients. in the present study, 190 wound isolates obtained from patients admitted to the burn ward at the pt. b.d. sharma pgims, rohtak, were evaluated f ... | 2017 | 28592933 |
| evaluation of the in vitro antimicrobial activity of selected saudi scorpion venoms tested against multidrug-resistant micro-organisms. | scorpion venoms are a rich source of bioactive peptides with promising clinical value that may lead to the discovery and development of new drugs. the present study was designed to evaluate the in vitro antimicrobial activities of the venoms extracted from three medically important saudi scorpions (androctonus crassicauda, androctonus bicolor and leiurus quinquestriatus). | 2017 | 28587870 |
| bacteria from animals as a pool of antimicrobial resistance genes. | antimicrobial agents are used in both veterinary and human medicine. the intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. this review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of ... | 2017 | 28587316 |
| properties of probiotics kocuria sm1 and rhodococcus sm2 isolated from fish guts. | this study characterized probiotics kocuria sm1 and rhodococcus sm2, which were recovered from the intestinal microbiota of rainbow trout (oncorhynchus mykiss, walbaum). the cultures were gram-positive, non-motile, catalase-positive and oxidase-negative cocci or rods. cell multiplication of sm1 and sm2 was observed at 4-37 °c (45 °c for sm1), in 0-20% (w/v) nacl and at ph 2-11. the viability was not affected when exposed to pepsin at ph 2.0 and 3.0, and pancreatin at ph 8.0. neither isolates wer ... | 2017 | 28585158 |
| transmission of health care-associated infections from roommates and prior room occupants: a systematic review. | pathogens that cause health care-associated infections (hais) are known to survive on surfaces and equipment in health care environments despite routine cleaning. as a result, the infection status of prior room occupants and roommates may play a role in hai transmission. we performed a systematic review of the literature evaluating the association between patients' exposure to infected/colonized hospital roommates or prior room occupants and their risk of infection/colonization with the same org ... | 2017 | 28579835 |
| design of live attenuated bacterial vaccines based on d-glutamate auxotrophy. | vaccine development is a priority for global health due to the growing multidrug resistance in bacteria. d-glutamate synthesis is essential for bacterial cell wall formation. here we present a strategy for generating effective bacterial whole-cell vaccines auxotrophic for d-glutamate. we apply this strategy to generate d-glutamate auxotrophic vaccines for three major pathogens, acinetobacter baumannii, pseudomonas aeruginosa and staphylococcus aureus. these bacterial vaccines show virulence atte ... | 2017 | 28548079 |
| celecoxib enhances the efficacy of low-dose antibiotic treatment against polymicrobial sepsis in mice and clinical isolates of eskape pathogens. | treatment of multidrug resistant bacterial infections has been a great challenge globally. previous studies including our study have highlighted the use of celecoxib, a non-steroidal anti-inflammatory drug in combination with antibiotic has decreased the minimal inhibitory concentration to limit staphylococcus aureus infection. however, the efficacy of this combinatorial treatment against various pathogenic bacteria is not determined. therefore, we have evaluated the potential use of celecoxib i ... | 2017 | 28533769 |
| development of a gold nanoparticle-based universal oligonucleotide microarray for multiplex and low-cost detection of foodborne pathogens. | bacterial foodborne diseases remain major threats to food safety and public health, especially in developing countries. in this study a novel assay, combining gold nanoparticle (gnp)-based multiplex oligonucleotide ligation-pcr and universal oligonucleotide microarray technology, was developed for inexpensive, specific, sensitive, and multiplex detection of eight common foodborne pathogens, including shigella spp., campylobacter jejuni, bacillus cereus, escherichia coli o157:h7, listeria monocyt ... | 2017 | 28505584 |
| biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype. | bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (mdros). nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. gram-negative bacteria were ... | 2017 | 28513576 |
| bactericidal activity of herbal volatile oil extracts against multidrug-resistant acinetobacter baumannii. | the aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal (alpinia galanga linn.), ginger (zingiber officinale), plai (zingiber cassumunar roxb.), lime (citrus aurantifolia), kaffir lime (citrus hystrix dc.), sweet basil (ocimum basilicum linn.), tree basil (ocimum gratissimum), lemongrass (cymbopogon citratus dc.), clove (syzygium aromaticum), and cinnamon (cinnamomum verum) against four standard strains of staphylo ... | 2017 | 28512603 |
| antibacterial action of jineol isolated from scolopendra subspinipes mutilans against selected foodborne pathogens. | this study was undertaken to assess the antibacterial potential of 3,8-dihydroxyquinoline (jineol) isolated from scolopendra subspinipes mutilans against selected foodborne pathogens escherichia coli o157:h7 and staphylococcus aureus kctc-1621. jineol at the tested concentration (50 μl; corresponding to 250 μg/disk) exhibited significant antibacterial effects as a diameter of inhibition zones (11.6-13.6 mm), along with minimum inhibitory concentration (mic) and minimum bactericidal concentration ... | 2017 | 28400770 |
| punica granatum peel extracts: hplc fractionation and lc ms analysis to quest compounds having activity against multidrug resistant bacteria. | medicinal plants are rich source of traditional herbal medicine around the globe. most of the plant's therapeutic properties are due to the presence of secondary bioactive compounds. | 2017 | 28468660 |
| reduction in fecal microbiota diversity and short-chain fatty acid producers in methicillin-resistant staphylococcus aureus infected individuals as revealed by pacbio single molecule, real-time sequencing technology. | methicillin-resistant staphylococcus aureus (mrsa) may cause potentially lethal infections. increasing evidence suggests that the gut microbiota is associated with human health. yet, whether patients with mrsa infections carry specific signatures in their fecal microbiota composition has not been determined. thus, this study aimed to compare the fecal microbiota profile of mrsa-positive patients (n=15) with individuals without mrsa infection (n=15) by using the pacbio single molecule, real-time ... | 2017 | 28455781 |
| thiolated aunp probes and multiplex pcr for molecular detection of staphylococcus epidermidis. | the emergence of nanotechnology in biology helps to apply the gold nanoparticle probes for fast and accurate identification of pathogens compared to the time-consuming and non-precise phenotypic methods. in this study, two molecular methods have been established for the accurate identification of staphylococcus epidermidis from other coagulase-negative staphylococci. multiplex pcr was performed using designed primers for gmk2 and pta housekeeping genes, and sesb specific gene of s. epidermidis. ... | 2017 | 28461258 |
| the use of bloodstream infection mortality to measure the impact of antimicrobial stewardship interventions: assessing the evidence. | this review sets out to evaluate the current evidence on the impact of inappropriate therapy on bloodstream infections (bsi) and associated mortality. based on the premise that better prescribing practices should result in better patient outcomes, bsi mortality may be a useful metric to evaluate antimicrobial stewardship (ams) interventions. a systematic search was performed in key medical databases to identify papers published in english between 2005 and 2015 that examined the association betwe ... | 2017 | 28458799 |
| copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: antimicrobial and biophysical properties. | a series of four thiosemicarbazones from 6-nitropiperonal along with the corresponding copper complexes were synthesized. the biophysical characteristics of the complexes were investigated by the binding to dna and human serum albumin. the binding to dna is moderate; the binding constants run from (0.49-7.50)×10(4)m(-1). in relation to hsa, the complexes interact strongly with binding constants on the order of 10(5)m(-1). the complexes also display antioxidant behavior as determined by the abili ... | 2017 | 28448954 |
| resistance profiles and risk factors of resistant microorganisms in bacteraemia of abdominal origin. | the presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. the objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. | 2017 | 28434558 |
| next generation sequencing-based multigene panel for high throughput detection of food-borne pathogens. | contamination of food by chemicals or pathogenic bacteria may cause particular illnesses that are linked to food consumption, commonly referred to as foodborne diseases. bacteria are present in/on various foods products, such as fruits, vegetables and ready-to-eat products. bacteria that cause foodborne diseases are known as foodborne pathogens (fbps). accurate detection methods that are able to reveal the presence of fbps in food matrices are in constant demand, in order to ensure safe foods wi ... | 2017 | 28578266 |
| trimethyl chitosan-capped silver nanoparticles with positive surface charge: their catalytic activity and antibacterial spectrum including multidrug-resistant strains of acinetobacter baumannii. | we report a facile route for the green synthesis of trimethyl chitosan nitrate-capped silver nanoparticles (tmcn-agnps) with positive surface charge. in this synthesis, silver nitrate, glucose, and trimethyl chitosan nitrate (tmcn) were used as silver precursor, reducing agent, and stabilizer, respectively. the reaction was carried out in a stirred basic aqueous medium at room temperature without the use of energy-consuming or expensive equipment. we investigated the effects of the concentration ... | 2017 | 28411476 |
| frequency and antibiogram of isolates from surgical units of a tertiary care hospital in quetta. | to determine the frequency and antibiogram of the isolates from infected patients in surgical units of a tertiary care hospital. | 2017 | 28406770 |
| synthesis and characterization of tetrahydropyran-based bacterial topoisomerase inhibitors with antibacterial activity against gram-negative bacteria. | there is an urgent unmet medical need for novel antibiotics that are effective against a broad range of bacterial species, especially multidrug resistant ones. tetrahydropyran-based inhibitors of bacterial type ii topoisomerases (dna gyrase and topoisomerase iv) display potent activity against gram-positive pathogens and no target-mediated cross-resistance with fluoroquinolones. we report our research efforts aimed at expanding the antibacterial spectrum of this class of molecules toward difficu ... | 2017 | 28406300 |
| a topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity. | many infectious diseases are associated with multidrug-resistant (mdr) bacteria residing in biofilms that require high antibiotic concentrations. while oral drug delivery is frequently ineffective, topical treatments have the potential to deliver higher drug concentrations to the infection site while reducing systemic side effects. this study determined the antibiofilm activity of a surgical wound gel loaded with the iron chelator deferiprone (def) and the heme analogue gallium-protoporphyrin (g ... | 2017 | 28396543 |
| in vitro selection and identification of potential probiotics isolated from the gastrointestinal tract of nile tilapia, oreochromis niloticus. | fish gut bacteria can be used as probiotics for aquaculture. the aim of this study is to screen and identify beneficial probiotic bacteria from the gut of nile tilapia, oreochromis niloticus. nine out of one hundred thirty-five isolates were non-pathogenic through intraperitoneal injection and had antibacterial activities with at least a strain from the five isolated fish pathogens, aeromonas sobria, aeromonas hydrophila, pseudomonas aeruginosa, pseudomonas putida, and staphylococcus aureus. fur ... | 2017 | 28819794 |
| assessment of cultivable oral bacterial flora from important venomous snakes of india and their antibiotic susceptibilities. | snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of india. snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. the pathogens from the oral cavity of the snake tend to initiate an infection, resulting ... | 2017 | 28733908 |
| haematological changes in south indian fresh water murrel, channa punctatus have both eus and a. hydrophila infection. | the mixed infection in fishes is a common feature and in this pathogens like bacteria, fungi and protozoan's are found together to cause ill health to the fishes known as epizootic ulcerative syndrome (eus). in this syndrome the low temperature and aquatic pollution aggravates the infection in fishes. in the present study the fresh water edible fish, channa punctatus (murrel) was found infected with the bacteria namely, aeromonas hydrophila, staphylococcus aureus, pseudomonas aeruginosa and salm ... | 2017 | 28615835 |
| bovine mastitis prevention: humoral and cellular response of dairy cows inoculated with lactic acid bacteria at the dry-off period. | the use of lactic acid bacteria (lab) in animal feed, constitute an alternative tool for bovine mastitis prevention. previously, two lab strains were isolated from bovine milk and selected for their probiotics properties. so far, immune response of inoculating lab in bovine udders at dry-off period has not been investigated. the immunoglobulin isotype levels and memory cell proliferation in blood and milk of animals inoculated with lactobacillus lactis subsp. lactis crl1655 and lactobacillus per ... | 2017 | 28701082 |
| the prevalence of antibiotic-resistant bacteria (arb) in waters of the lower ballona creek watershed, los angeles county, california. | screening for the prevalence of antibiotic-resistant bacteria (arb) was done at the ballona creek and wetlands, an urban-impacted wetland system in los angeles, california. the goals were (1) to assess the overall prevalence of arb, and (2) compare differences in arb abundance and the types of antibiotic resistance (ar) among the following sample types: lagoon water from del rey lagoon, urban runoff from ballona creek, and water from the ballona wetlands (tidal water flooding in from the adjacen ... | 2017 | 28488226 |
| antagonistic properties of some halophilic thermoactinomycetes isolated from superficial sediment of a solar saltern and production of cyclic antimicrobial peptides by the novel isolate paludifilum halophilum. | this study has focused on the isolation of twenty-three halophilic actinomycetes from two ponds of different salinity and the evaluation of their ability to exert an antimicrobial activity against both their competitors and several other pathogens. from the 23 isolates, 18 strains showed antagonistic activity, while 19 showed activities against one or more of the seven pathogen strains tested. six strains exhibited consistent antibacterial activity against gram-negative and gram-positive pathoge ... | 2017 | 28819625 |
| dynamics of mono- and dual-species biofilm formation and interactions between staphylococcus aureus and gram-negative bacteria. | microorganisms are not commonly found in the planktonic state but predominantly form dual- and multispecies biofilms in almost all natural environments. bacteria in multispecies biofilms cooperate, compete or have neutral interactions according to the involved species. here, the development of mono- and dual-species biofilms formed by staphylococcus aureus and other foodborne pathogens such as salmonella enterica subsp. enterica serovar enteritidis, potentially pathogenic raoultella planticola a ... | 2017 | 28401747 |
| risk of cardiac pacemaker pocket infection in a tertiary care hospital. | the risk of pacemaker pocket infections (ppis) is rare with good antisepsis techniques and use of advanced antibiotics. however, injudicious antibiotic usage leads to the rise of multidrug-resistant bacteria, which may cause ppi. few reports exist about the microbial spectrum of the ppi from our country, prompting us to study the same. | 2017 | 28631632 |
| antimicrobial consumption, costs and resistance patterns: a two year prospective study in a romanian intensive care unit. | due to the vulnerable nature of its patients, the wide use of invasive devices and broad-spectrum antimicrobials used, the intensive care unit (icu) is often called the epicentre of infections. in the present study, we quantified the burden of hospital acquired pathology in a romanian university hospital icu, represented by antimicrobial agents consumption, costs and local resistance patterns, in order to identify multimodal interventional strategies. | 2017 | 28532467 |
| national survey of practices to prevent methicillin-resistant staphylococcus aureus and multidrug-resistant acinetobacter baumannii in thailand. | we evaluated the extent to which hospital characteristics, infection control practices, and compliance with prevention bundles impacted multidrug-resistant organism (mdro) infections in thai hospitals. | 2017 | 28475783 |
| eco-friendly synthesis of silver nanoparticles using green algae (caulerpa serrulata): reaction optimization, catalytic and antibacterial activities. | stable colloidal silver nanoparticles (agnps) were synthesized using caulerpa serrulata (green marine algae) aqueous extract as an efficient reducing and stabilizing agent. this method is considered to be a sustainable alternate to the more complicated chemical procedures. to achieve the optimization synthesis of agnps, several effects such as extract concentration, contact time, ph values, and temperature were examined. the synthesized agnps were characterized by uv-vis spectroscopy, ft-ir, xrd ... | 2017 | 28646435 |
| pre-banking microbial contamination of donor conjunctiva and storage medium for penetrating keratoplasty. | the aims of this study were to investigate the incidence of positive donor tissue cultures before transfer to preservation medium (optisol™-gs) for penetrating keratoplasty, to verify the efficacy of antibiotics contained in optisol™-gs by examining the drug susceptibility and to assess the relationship between the results of our microbial assessments as well as donor factors and the incidence of contamination. | 2017 | 28597192 |
| sensitive detection of staphylococcus aureus with vancomycin-conjugated magnetic beads as enrichment carriers combined with flow cytometry. | a novel sandwich strategy was designed to detect staphylococcus aureus. the strategy is based on an antibacterial agent that captures bacterial cells and a fluorescein-labeled antibody that acts as the signal-output probe. vancomycin (van), which exerts a strong antibacterial effect on gram-positive bacteria, was utilized as a molecular recognition agent to detect pathogenic bacteria. to effectively concentrate s. aureus, we used bovine serum albumin (bsa) as the amplification carrier to modify ... | 2017 | 28590745 |
| bactericidal effect of 266 to 279nm wavelength uvc-leds for inactivation of gram positive and gram negative foodborne pathogenic bacteria and yeasts. | recently, uvc-led technology has been validated as an alternative to irradiation with conventional mercury uv lamps. in this study, we sought to determine primary factors affecting reduction trends shown in several microorganisms. four major foodborne pathogens (escherichia coli o157:h7, salmonella spp. listeria monocytogenes, staphylococcus aureus) and spoilage yeasts (saccharomyces pastorianus, pichia membranaefaciens), important to the brewing industry, were inoculated onto selective and non- ... | 2017 | 28578053 |
| endogenous bacterial endophthalmitis. a report of 2cases. | the cases are presented on 2patients with bacterial endogenous endophthalmitis. the first one was caused by streptococcus bovis, developed after colonoscopy, which had a poor outcome and resulted in evisceration. the second case was caused by a methicillin resistant staphylococcus aureus from an arthrodesis complicated with a para-spinal abscess. it had an excellent visual outcome. | 2017 | 28427732 |
| [brain abscess in children: ten years of experience in a third level pediatric hospital]. | brain abscess is a focal infection that occurs with a frequency of 0.3-1.3 cases per 100,000 people/year. we describe the epidemiology, clinical and microbiology characteristics of 38 children diagnosed with brain abscess hospitalized between 4/1/2005 and 12/31/2015 at hospital de pediatría "prof. dr. juan p. garrahan" in buenos aires city. twenty-four patients were male. the median age was 132 months. predisposing factors were detected in 25 children. the median evolution from onset of symptoms ... | 2017 | 28737874 |
| update on the epidemiology and antibiotic resistance of ocular infections. | the purpose of this review is to provide an update on the epidemiology and current antibiotic-resistant threats in ophthalmology. | 2017 | 28546690 |
| the changing epidemiology and clinical features of infective endocarditis: a retrospective study of 196 episodes in a teaching hospital in china. | infective endocarditis is an uncommon but life-threatening infectious disease. to our knowledge, current investigations of the characteristics of infective endocarditis in our region are scarce. in this study, we aimed to investigate the changes in the epidemiology and clinical features of infective endocarditis. | 2017 | 28482820 |
| production and characterization of a new biodegradable fenugreek seed gum based active nanocomposite film reinforced with nanoclays. | in the present work, fenugreek seed gum (fsg)/clay nanocomposite films were prepared with nanoclays (na(+) montmorillonite [mmt], halloysite [hnt] and nanomer(®) i.44 p [nm]) at different amounts (0, 2.5, 5.0 and 7.5g clay/100g fsg) by solution casting method and characterized. increasing amount of nanoclay significantly (p<0.05) improved oxygen barrier and thermal properties of the biodegradable films. agar diffusion tests revealed that fsg based nanocomposite films exhibited strong antimicrobi ... | 2017 | 28536016 |
| [synthesis of antibiotic loaded polylactic acid nanoparticles and their antibacterial activity against escherichia coli o157:h7 and methicillin-resistant staphylococcus aureus]. | polymeric nanoparticles are promising nanotechnology tools to fight pathogenic bacteria resistant to conventional antibiotics. | 2017 | 28527243 |
| mitochondria-targeted antioxidants as highly effective antibiotics. | mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. here, we showed that skq1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards gram-positive bacillus subtilis, mycobacterium sp. and staphylococcus aureus and gram-negative photobacterium phosphoreum and rhodobacter sphaeroides in submicromolar and micromolar concentrations. skq1 exhibited less ant ... | 2017 | 28469140 |
| newly identified invertebrate-type lysozyme (splys-i) in mud crab (scylla paramamosain) exhibiting muramidase-deficient antimicrobial activity. | lysozymes are widely distributed immune effectors exerting muramidase activity against the peptidoglycan of the bacterial cell wall to trigger cell lysis. however, some invertebrate-type (i-type) lysozymes deficient of muramidase activity still exhibit antimicrobial activity. to date, the mechanism underlying the antimicrobial effect of muramidase-deficient i-type lysozymes remains unclear. accordingly, this study characterized a novel i-type lysozyme, splys-i, in the mud crab scylla paramamosai ... | 2017 | 28438599 |
| phytosynthesis of silver nanoparticles using aqueous leaf extracts of lippia citriodora: antimicrobial, larvicidal and photocatalytic evaluations. | nanoscience and nanotechnology represent new and enabling platforms that promise to provide broad range of novel and improved technologies for environmental, biological and other scientific applications. this study reports the synthesis of silver nanoparticles mediated by aqueous leaf extract of lippia citriodora at two different temperatures of 50°c and 90°c. the synthesis of colloidal silver nanoparticles (agnps) was monitored by the use of uv-visible spectroscopy at different temperatures and ... | 2017 | 28415554 |
| isolation, purification, and characterization of five active diketopiperazine derivatives from endophytic streptomyces suk 25 with antimicrobial and cytotoxic activities. | in our search for new sources of bioactive secondary metabolites from streptomyces sp., the ethyl acetate extracts from endophytic streptomyces suk 25 afforded five active diketopiperazine (dkp) compounds. the aim of this study was to characterize the bioactive compounds isolated from endophytic streptomyces suk 25 and evaluate their bioactivity against multiple drug resistance (mdr) bacteria such as enterococcus raffinosus, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumanii, p ... | 2017 | 28535606 |
| lobophorin k, a new natural product with cytotoxic activity produced by streptomyces sp. m-207 associated with the deep-sea coral lophelia pertusa. | the present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin k (1), from cultures of the marine actinobacteria streptomyces sp. m-207, previously isolated from the cold-water coral lophelia pertusa collected at 1800 m depth during an expedition to the submarine avilés canyon. its structure was determined using a combination of spectroscopic techniques, mainly esi-tof ms and 1d and 2d nmr. this new natural product displayed cytotoxic acti ... | 2017 | 28534807 |
| effect of variable aminoalkyl chains on chemical grafting of cellulose nanofiber and their antimicrobial activity. | recent focus on the preparation of antimicrobial surfaces using cellulose nanofibers (cnf) has gained considerable attention. in this work, functionalization of cnf films in 100% aqueous solution with three different aminosilanes, including 3-aminopropyl trimethoxysilane (apms), 2-aminoethyl 3-aminopropyl trimethoxysilane (dams)and 3-2-(2-aminoethylamino) ethylamino propyl-trimethoxysilane (tams) is reported for the fabrication of contact active antimicrobial materials. grafted cnf films were co ... | 2017 | 28415526 |
| labradorins with antibacterial activity produced by pseudomonas sp. | the urgent need for new antibacterial drugs has led to renewed interest in microorganisms, which historically have been the main source of previously discovered antibiotics. the present study describes the discovery of two new antibacterial oxazolylindole type alkaloids, labradorins 5 (1) and 6 (2), which were isolated and characterized from two isolates of pseudomonas sp., along with four previously known tryptophane derived alkaloids. the structures of 1 and 2 were determined by nmr spectrosco ... | 2017 | 28654009 |
| palivizumab prophylaxis in infants with cystic fibrosis does not delay first isolation of pseudomonas aeruginosa or staphylococcus aureus. | respiratory syncytial virus (rsv) infections may worsen cystic fibrosis (cf) lung disease and favor pseudomonas aeruginosa (pa) or staphylococcus aureus (sa) acquisition, which is of particular importance in the youngest patients. we aimed to determine the effectiveness of pvz on microbiological outcomes in young children with cf. we conducted a retrospective case-control study to compare these outcomes in children who systematically received pvz (pvz+; n = 40) or not (pvz-; n = 140). one case w ... | 2017 | 28508992 |
| a proteomic signature of dormancy in the actinobacterium micrococcus luteus. | dormancy is a protective state in which diverse bacteria, including mycobacterium tuberculosis, staphylococcus aureus, treponema pallidum (syphilis), and borrelia burgdorferi (lyme disease), curtail metabolic activity to survive external stresses, including antibiotics. evidence suggests dormancy consists of a continuum of interrelated states, including viable but nonculturable (vbnc) and persistence states. vbnc and persistence contribute to antibiotic tolerance, reemergence from latent infecti ... | 2017 | 28484042 |
| sensitivity to antibiotics of bacteria exposed to gamma radiation emitted from hot soils of the high background radiation areas of ramsar, northern iran. | over the past several years our laboratories have investigated different aspects of the challenging issue of the alterations in bacterial susceptibility to antibiotics induced by physical stresses. | 2017 | 28432369 |
| structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation. | hydrogen sulfide (h2s) is a signaling molecule that is toxic at elevated concentrations. in eukaryotes, it is cleared via a mitochondrial sulfide oxidation pathway, which comprises sulfide quinone oxidoreductase, persulfide dioxygenase (pdo), rhodanese, and sulfite oxidase and converts h2s to thiosulfate and sulfate. natural fusions between the non-heme iron containing pdo and rhodanese, a thiol sulfurtransferase, exist in some bacteria. however, little is known about the role of the pdo-rhodane ... | 2017 | 28684420 |
| seven new lignan glycosides from the branches of alangium kurzii craib var. laxifolium. | seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of alangium kurzii craib var. laxifolium. their structures were established by spectroscopic analysis and circular dichroism (cd) and x-ray analysis. the isolated compounds were evaluated for their antibacterial activities against staphylococcus aureus ci1011, streptococcus suis ci1608, salmonella gallinarum ci0912, enterococcus faecalis ci1304, aeromonas hydrophila ci1008, escherichia coli ci1 ... | 2017 | 28733150 |
| antibacterial effects of lactobacillus isolates of curd and human milk origin against food-borne and human pathogens. | this study was undertaken to assess the antibacterial efficacy of lactobacilli isolated from curd and human milk samples. identities of thirty-one different lactobacilli (20 from curd and 11 from human milk) were confirmed by genus-specific pcr and 16s rrna-based sequencing. these strains belonged to five species, lactobacillus casei, l. delbrueckii, l. fermentum, l. plantarum, and l. pentosus. antibacterial activities of cell-free supernatants (cfss) of all the lactobacillus isolates were estim ... | 2017 | 28401466 |
| chalcomycins from marine-derived streptomyces sp. and their antimicrobial activities. | dihydrochalcomycin (1) and chalcomycin, (2), two known chalcomycins, and chalcomycin e (3), a new compound, were isolated from marine-derived streptomyces sp. hk-2006-1. their structures were elucidated by detailed spectroscopic and x-ray crystallographic analysis. the antimicrobial activities against staphylococcus aureus, escherichia coli, candida albicans, and aspergillus niger of 1-3 were evaluated. compounds 1-2 exhibited activities against s. aureus with minimal inhibitory concentrations ( ... | 2017 | 28555051 |
| streptomyces sp. at37 isolated from a saharan soil produces a furanone derivative active against multidrug-resistant staphylococcus aureus. | a novel actinobacterium strain, named at37, showed a strong activity against some multidrug-resistant staphylococcus aureus, including methicillin-resistant s. aureus mrsa atcc 43300, other clinical isolates of mrsa and vancomycin resistant s. aureus vrsa s1. the strain at37 was isolated from a saharan soil by a dilution agar plating method using chitin-vitamin agar medium supplemented with rifampicin. the morphological and chemical studies indicated that this strain belonged to the genus strept ... | 2017 | 28466299 |
| identification of a macrobrachium nipponense c-type lectin with a close evolutionary relationship to vertebrate lectins. | c-type lectins (ctls) are involved in the innate immune defense of vertebrates and invertebrates against invading pathogens. this study cloned and characterized a novel c-type lectin (mnctl) of the oriental river prawn, macrobrachium nipponense. the cloned mnctl cdna encompasses an open reading frame of 774 nucleotides and encodes polypeptides of 257 residues. the deduced mnctl protein contains a single carbohydrate recognition domain (crd) with an epn (glu-pro-asn) motif in calcium-binding site ... | 2017 | 28441623 |
| microbiology of the upper and lower airways in pediatric cystic fibrosis patients. | objective to evaluate the microbiology of the upper and lower airways in pediatric cystic fibrosis (cf) patients who underwent sinus surgery. study design retrospective case series with chart review. setting tertiary care children's hospital. subjects and methods a total of 201 paired sinus and pulmonary cultures from 105 cf patients were identified between 1996 and 2014. demographics and culture results were analyzed. results the mean age of patients was 11.2 ± 5.4 years (range, 1-27 years), an ... | 2017 | 28440108 |
| antimicrobial activity and chemical composition of brunfelsia uniflora flower oleoresin extracted by supercritical carbon dioxide. | brunfelsia genus is traditionally utilized in popular medicine due to its antibacterial and antifungal properties to name but a few. however, studies on the antimicrobial activity of brunfelsia uniflora flower oleoresin have not been found yet. this study aimed to evaluate the chemical composition and antimicrobial activity of b. uniflora flower oleoresin obtained by supercritical carbon dioxide. oleoresin from the plant dried flowers was obtained by carbon dioxide, and the chemical composition ... | 2017 | 28407186 |
| a simple way to eradicate methicillin-resistant staphylococcus aureus in cynomolgus macaques (macaca fascicularis). | our investigation of indoor-housed cynomolgus macaques (macaca fascicularis) by using automated identification followed by antibiotic susceptibility testing revealed 1 of 7 immunocompetent animals and 2 of 9 immunosuppressed monkeys as carriers of methicillin-resistant staphylococcus aureus (mrsa). follow-up management involving mupirocin treatment resulted in the conversion of the 3 mrsa carriers into mrsa-negative cases. prospective assessment of newly imported monkeys involving 24-h culture o ... | 2017 | 28830583 |
| a simple way to eradicate methicillin-resistant staphylococcus aureus in cynomolgus macaques (macaca fascicularis). | our investigation of indoor-housed cynomolgus macaques (macaca fascicularis) by using automated identification followedbyantibiotic susceptibility testing revealed 1 of 7 immunocompetent animals and 2 of 9 immunosuppressed monkeys as carriers ofmethicillin-resistant staphylococcus aureus (mrsa). follow-up management involving mupirocin treatment resulted in the conversion of the 3 mrsa carriers into mrsa-negative cases. prospective assessment of newly imported monkeys involving 24-h culture of n ... | 2017 | 28462776 |
| green synthesis and characterization of gold and silver nanoparticles using mussaenda glabrata leaf extract and their environmental applications to dye degradation. | plant-derived nanomaterials opened a green approach in solving the current environment issues. present study focused on rapid microwave-assisted synthesis and applications of gold and silver nanoparticles mediated by aqueous leaf extract of mussaenda glabrata. the synthesized nanoparticles were characterized by uv-vis, ft-ir, powder xrd, energy-dispersive x-ray spectroscopy (edx), transmission electron (tem), and atomic force microscopic techniques (afm). fcc crystal structure of both nanopartic ... | 2017 | 28589274 |
| a human biofilm-disrupting monoclonal antibody potentiates antibiotic efficacy in rodent models of both staphylococcus aureus and acinetobacter baumannii infections. | many serious bacterial infections are antibiotic-refractory due to biofilm formation. a key structural component of biofilm is extracellular dna which is stabilized by bacterial proteins, including those from the dnabii family. trl1068 is a high affinity human monoclonal antibody against a dnabii epitope conserved across both gram-positive and gram-negative bacterial species. in the current study, the efficacy of trl1068 for disruption of biofilm was demonstrated in vitro in the absence of antib ... | 2017 | 28717038 |
| reduction of reactive red 241 by oxygen insensitive azoreductase purified from a novel strain staphylococcus ku898286. | an oxygen insensitive azoreductase was purified from a novel bacterial strain (staphylococcus sp. ku898286) that was isolated from an abandoned site of the textile waste discharge unit. the isolated enzyme had efficiently cleaved the azo-bonds through reductive transformation under aerobic conditions. initial phenotypic characterization and final construction of phylogenetic tree on the basis of 16s rdna demonstrated 99% resemblance of the isolate to staphylococcus aureus. the purified azoreduct ... | 2017 | 28467413 |
| effects of lactobacillus rhamnosus and lactobacillus acidophilus on bacterial vaginal pathogens. | the human vagina is colonized by a variety of microbes. lactobacilli are the most common, mainly in healthy women; however, the microbiota composition can change rapidly, leading to infection or to a state in which potential pathogenic microorganisms co-exist with other commensals. in premenopausal women, urogenital infections, such as bacterial vaginosis and aerobic vaginitis, remain an important health problem. treatment of these infections involves different kind of antibiotics; however, the ... | 2017 | 28580872 |
| characterisation and antimicrobial activity of biosurfactant extracts produced by bacillus amyloliquefaciens and pseudomonas aeruginosa isolated from a wastewater treatment plant. | biosurfactants are unique secondary metabolites, synthesised non-ribosomally by certain bacteria, fungi and yeast, with their most promising applications as antimicrobial agents and surfactants in the medical and food industries. naturally produced glycolipids and lipopeptides are found as a mixture of congeners, which increases their antimicrobial potency. sensitive analysis techniques, such as liquid chromatography coupled to mass spectrometry, enable the fingerprinting of different biosurfact ... | 2017 | 28571306 |
| functional silver nanocomposites as broad-spectrum antimicrobial and biofilm-disrupting agents. | biofilms' tolerance has become a serious clinical concern due to their formidable resistance to conventional antibiotics and prevalent virulence. therefore, there is an urgent need to develop alternative antimicrobial agents to eradicate biofilms but avoid using antibiotics. herein, we successfully developed polymer functional silver nanocomposites by reduction of silver nitrate in the presence of a biocompatible carbohydrate polymer and a membrane-disrupting cationic polymer. the nanocomposites ... | 2017 | 28481506 |