Publications

TitleAbstractYear(sorted descending)
Filter
PMID
Filter
hla-b27 and human β2-microglobulin affect the gut microbiota of transgenic rats.the hla-b27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic arthritis, but its mechanism of risk enhancement is not completely understood. the gut microbiome has recently been shown to influence several hla-linked diseases. however, the role of hla-b27 in shaping the gut microbiome has not been previously investigated. in this study, we characterize the differences in the gut microbiota mediated by the ...201425140823
bacterial sensor nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal bacteroides vulgatus.nod2 has been extensively characterized as a bacterial sensor that induces an antimicrobial and inflammatory gene expression program. therefore, it is unclear why nod2 mutations that disrupt bacterial recognition are paradoxically among the highest risk factors for crohn's disease, which involves an exaggerated immune response directed at intestinal bacteria. here, we identified several abnormalities in the small-intestinal epithelium of nod2(-/-) mice including inflammatory gene expression and ...201425088769
l-galactose metabolism in bacteroides vulgatus from the human gut microbiota.a previously unknown metabolic pathway for the utilization of l-galactose was discovered in a prevalent gut bacterium, bacteroides vulgatus. the new pathway consists of three previously uncharacterized enzymes that were found to be responsible for the conversion of l-galactose to d-tagaturonate. bvu0219 (l-galactose dehydrogenase) was determined to oxidize l-galactose to l-galactono-1,5-lactone with kcat and kcat/km values of 21 s(-1) and 2.0 × 10(5) m(-1) s(-1), respectively. the kinetic produc ...201424963813
individually addressable arrays of replica microbial cultures enabled by splitting slipchips.isolating microbes carrying genes of interest from environmental samples is important for applications in biology and medicine. however, this involves the use of genetic assays that often require lysis of microbial cells, which is not compatible with the goal of obtaining live cells for isolation and culture. this paper describes the design, fabrication, biological validation, and underlying physics of a microfluidic slipchip device that addresses this challenge. the device is composed of two co ...201424953827
production of ai-2 is mediated by the s-ribosylhomocystein lyase gene luxs in bacteroides fragilis and bacteroides vulgatus.quorum sensing is a cell-cell signaling mechanism based on cell density and that involves the production of hormone-like molecules called autoinducers (ai). one of the most studied ais has been termed ai-2, and its biosynthesis requires the enzyme encoded by luxs. we have previously described for the first time that bacteroides species can produce molecules with ai-2 activity. in this study, we focus on the detection of luxs and its activity as the ai-2 synthase in bacteroides species. the strai ...201424026770
bacteroides dorei dominates gut microbiome prior to autoimmunity in finnish children at high risk for type 1 diabetes.the incidence of the autoimmune disease, type 1 diabetes (t1d), has increased dramatically over the last half century in many developed countries and is particularly high in finland and other nordic countries. along with genetic predisposition, environmental factors are thought to play a critical role in this increase. as with other autoimmune diseases, the gut microbiome is thought to play a potential role in controlling progression to t1d in children with high genetic risk, but we know little ...201425540641
[bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents - special references to bacteria isolated between april 2011 and march 2012].bacteria isolated from surgical infections during the period from april 2011 to march 2012 were investigated in a multicenter study in japan, and the following results were obtained. in this series, 785 strains including 31 strains of candida spp. were isolated from 204 (78.8%) of 259 patients with surgical infections. five hundred and twenty three strains were isolated from primary infections, and 231 strains were isolated from surgical site infection. from primary infections, anaerobic gram-ne ...201425796741
coexpression and secretion of endoglucanase and phytase genes in lactobacillus reuteri.a multifunctional transgenic lactobacillus with probiotic characteristics and an ability to degrade β-glucan and phytic acid (phytate) was engineered to improve nutrient utilization, increase production performance and decrease digestive diseases in broiler chickens. the bacillus subtilis wl001 endoglucanase gene (celw) and aspergillus fumigatus wl002 phytase gene (phyw) mature peptide (phywm) were cloned into an expression vector with the lactate dehydrogenase promoter of lactobacillus casei an ...201425050780
disrupted intestinal microbiota and intestinal inflammation in children with cystic fibrosis and its restoration with lactobacillus gg: a randomised clinical trial.intestinal inflammation is a hallmark of cystic fibrosis (cf). administration of probiotics can reduce intestinal inflammation and the incidence of pulmonary exacerbations. we investigated the composition of intestinal microbiota in children with cf and analyzed its relationship with intestinal inflammation. we also investigated the microflora structure before and after lactobacillus gg (lgg) administration in children with cf with and without antibiotic treatment.201424586292
senior thai fecal microbiota comparison between vegetarians and non-vegetarians using pcr-dgge and real-time pcr.the fecal microbiotas were investigated in 13 healthy thai subjects using polymerase chain reaction denaturing gradient gel electrophoresis (pcr-dgge). among the 186 dna bands detected on the polyacrylamide gel, 37 bands were identified as representing 11 species: bacteroides thetaiotaomicron, bacteroides ovatus, bacteroides uniformis, bacteroides vulgatus, clostridium colicanis, eubacterium eligenes, e. rectale, faecalibacterium prausnitzii, megamonas funiformis, prevotella copri, and roseburia ...201424743571
[laparoscopic extra- and intrahepatic angiography and pressure measurement]. 20144280624
[results of the treatment in fractures and dislocations of the cervical vertebrae. late results in 26 survivors]. 20144238935
reliability of glucose oxidase staining at the ultrastructural level for immunohistochemical studies. 20144111155
a new line on age pigment? 20144097957
[clinical and hemodynamic evolution of carpentier-edwards prostheses]. 20144015004
monoclonal antibodies to drugs: novel diagnostic and therapeutic reagents. 20143911217
thymidine salvage pathway in normal and leukemic leukocytes with effects of atp on enzyme control. 20144305274
[provision for and requirement of vitamin pp in patients with glaucoma]. 20144272972
[provision for and requirement of vitamin pp in patients with glaucoma]. 20144272972
the effect of thyroxine on peripheral thyroid hormone metabolism. 20144187946
[radiologic observations on lumbalgias]. 20144221792
solute migration during granule drying. 20144156730
the co2 laser for recurrent and therapy-resistant condylomata acuminata.the medical records of 48 patients who underwent laser vaporization of therapy-resistant or recurrent condylomata acuminata were studied with regard to history of immunosuppression, location of original lesion, type and duration of therapy, and whether magnification devices were used prior to or during therapy. the genitalia of the patients' sexual partners were examined in all cases in which the condylomata recurred after initial control of the lesions with conventional methods. in 46 of the 48 ...20144020791
[scintigraphic studies of bones in hemoblastoses]. 20144111754
[management of congenital hip dislocation with the hanausek method as compared with conventional procedures]. 20144273488
short stature and growth hormone deficiency in histiocytosis x. 20144424388
short stature and growth hormone deficiency in histiocytosis x. 20144424388
symbolism in the treatment of schizophrenia. 20144195343
rickets from liquid paraffin. 20144164140
microcomputers in clinical research: discussion paper. 20144020798
adverse effects secondary to baclofen withdrawal.drug therapy is now the preferred method of treatment for spasticity, and several effective agents have been developed. the safety and efficacy of these drugs has been established in short-term studies. overall, due to its low incidence of sedation and serious side effects, baclofen appears to be the drug of choice in the treatment of spinal cord-related spasticity. it is, however, not without its side effects due to both its administration and abrupt withdrawal. this case illustrates some signi ...20144006720
[diagnosis of lymphoma in abdominal lymph nodes]. 20143910869
[johann sebastian bach's eye operation and his surgeon sir john taylor]. 20143911076
the pulmonary circulation in children with congenital heart disease: morphologic and morphometric considerations. 20143896433
[normal fundi oculi in tumors of the posterior cranial fossa]. 20144319488
[normal fundi oculi in tumors of the posterior cranial fossa]. 20144319488
attachment of plaque and calculus to tooth surfaces. 20144255150
detectability of group-specific component (gc) in aged bloodstains.an improved method of group-specific component (gc) typing was conducted electrophoretically on agarose gel. individual bloodstains randomly collected from different individual donors over a five-year period at intervals of approximately one month were checked for gc activity. group-specific component was typed accurately in dried bloodstains stored at room temperature up to 43 months in age. from 100 different donors, bloodstains ranging in age from 38 to 43 months were tested by the methods de ...20144039746
asymptomatic carotid bruit. stenosis or ulceration, a conservative approach. 20143985815
[evaluation of a semiautomatic system (abac-abactor iii) for the identification of enterobacteriaceae].abac-abactor ii system has been compared with two conventional methods (enterotube ii and ms-2) for the identification of enterobacteriaceae. our findings demonstrate the validity and the reproducibility of the identification obtained with this system.20144059512
mathematical modelling of dynamics and control in metabolic networks. v. static bifurcations in single biochemical control loops.here we expand an earlier study of feedback activation in simple linear reaction sequences by searching the parameter space of biologically realistic rate laws for multiple stable steady states. the impetus for this work is to seek the origin of decision making strategies at the metabolic level, with particular emphasis on the switching between the operating conditions needed to meet changing substrate availability and organism requirements. the control loop considered herein is a linear reactio ...20143999779
[evolution and complications of suppurative meningitis]. 20144291410
[evolution and complications of suppurative meningitis]. 20144291410
role of pulmonary hypertension, hypoxaemia and right ventricular hypertrophy on the right heart failure in pulmonary heart diseases. 20144273123
[behavior of the very difficult child in the dental office. i. the cause]. 20144274837
[new facts concerning the hormonal supervision of malignant trophoblastomas. differentiations of the principal pituitary or chorionic gonadotropins in castrated subjects]. 20144293151
antiviral resistance by the polyinosinic acid-poly (1-vinylcytosine) complex.the antiviral activities of analogs of the double-stranded complex of polyinosinic and polycytidylic acids [poly(i).poly(c)], which is a potent interferon inducer, have been studied. structural changes that modify the polymer backbone substantially, such as loops or 2' --> 5' phosphodiester bonds, lead to decreased antiviral activity. unexpectedly, however, the complex of polyinosinic acid and poly(1-vinylcytosine), which is only a much more distantly related analog of poly(i) . poly(c), shows h ...20144324924
[on the storage of mucopolysaccharide-like substances in the brain in generalized glycogenosis (type ii)]. 20144223251
chromatin fibril size in salivary gland chromosomes of drosophila melanogaster. 20144202370
red cell 2,3-diphosphoglycerate in patients with hyperthyroidism before and after treatment. 20144139877
comparative mortality ratio--a health index. 20144077244
[clinical picture and treatment of nocturnal enuresis in children].the article presents the results of the treatment of 275 cases of nocturnal enuresis which are subdivided by the author into 3 forms according to the nature of the pathogenesis: neurotic, organic and familial. the neurotic form of eneuresis showed the best response to a combination of hypnotherapy with tranquilizers and antidepressants, the organic form was most responsive to nootropic agents, antidepressants and anticonvulsants. antidepressants were effective for the treatment of familial enure ...20143993305
[therapeutic problems in acromegaly]. 20144029005
invasion of privacy. 20143969230
the periphery of descemet's membrane. a study by light microscopy. 20144173658
[late-onset damage to the supporting system of leg amputees]. 20144272554
[apparatus for electrophoresis in starch gel]. 20144139385
[long-term therapy of the chronic bronchitis syndrome using tanderil]. 20144992075
chronic pediatric tracheotomy: assessment and implications for habilitation of voice, speech and language in young children.the effect of chronic tracheotomy on the acquisition of voice, speech, and language skills was studied. children with chronological ages of 16 months to 41 months were evaluated for receptive communication age (rca) and expressive communication age (eca). results indicate a consistent deviation of (on the average) 4.8 months delay in rca and 9 months delay in eca. an habilitation program for early intervention in voice, speech and language stimulation is described, with follow-up data on 3 child ...20144030238
[otological manifestations in hypothyroidism. clinical and experimental research]. 20144230230
[study of cerebro-vascular pathology in the newborn infant using doppler and frequency analysis. preliminary results]. 20143911101
brief report of mmpi characteristics of sexual deviation. 20144153764
[blood gases and acid-base equilibrium in children with bronchial asthma]. 20145029483
application of microvascular free osteocutaneous flaps in the management of post-radiation recurrent oral cancer.fifty-nine patients underwent free flap osteocutaneous reconstruction that consisted of flaps of the dorsum of the foot in 26 patients and iliac crest flaps in 33 with a success rate of 92 percent and a mortality rate of 1.6 percent. these flaps, which require the expertise of microvascular surgeons, are time-consuming and complicate operating room and time management, but they represent a remarkable advance in reconstruction that can facilitate cosmetic and functional recovery of the patient. i ...20143901789
effect of dialysate sodium on the dopamine, adrenaline and noradrenaline concentration in haemodialysis patients.in eight stable patients, plasma dopamine (da), adrenaline (a) and noradrenaline (na) was measured during haemodialysis with high sodium (148meq/l) and low sodium (131meq/l) dialysate. during haemodialysis and ultrafiltration with high dialysate sodium an increase of da, a and na was not observed in response to the cold pressor test (cd). however, with the low sodium dialysate an increase in da and na was observed during cd. we suggest that high sodium dialysate is connected with the sympathetic ...20143991502
[medullary cancer of the thyroid gland with amyloidosis of the stroma]. 20144249215
[the tasks of organized dentistry in the control of caries in greek children]. 20144231519
[the treatment of bronchiolar obstruction (author's transl)]. 20144155789
[experimental data on the penetration of hexachlorane into the soil]. 20144112874
[possibility of determination of the value of the ejection fraction of the left ventricle with non-invasive methods in ischemic cardiopathy]. 20144080166
prevention of physical and mental congenital defects. part b: epidemiology, early detection and therapy, and environmental factors. proceedings of an international conference of the institut de la vie. strasbourg, france, october 10-17, 1982. 20143983156
postnatal development of the telencephalon of the tammar wallaby (macropus eugenii). an accessible model of neocortical differentiation.the sequence of development of cell layers in the neocortex of the tammar has been followed from 24 days gestation to 213 days postnatal. the tammar is born at 27 days gestation and the major period of its development occurs during the subsequent 250 days, most of this time being spent within the pouch. although the pattern of differentiation of the cell layers appears to resemble that described for many eutherian mammals, the neocortex is at an embryonic 2 layered stage at birth and a cortical ...20144073534
[various problems relative to chemical aggression]. 20144235737
attention and prism adaptation. 20143995897
[use of triazine herbicides in the democratic republic of germany: toxicologic and hygienic problems]. 20133721217
acute changes in plasma steroids and agonistic behavior in male japanese quail.a systematic analysis of the acute (minutes to hours) fluctuations of plasma steroids [androstenedione (a), 5 alpha-dihydrotestosterone (dht), testosterone (t), corticosterone (b)] was investigated in relation to the fighting behavior displayed by experienced male japanese quail (coturnix coturnix) in short-term (2 min) dyadic encounters. plasma levels of hormones measured in competitors either 1 hr before, during, or 3 min to 6 hr following a fight related poorly to either the attacking or nona ...20134054584
passive smoking and taxi-drivers. 20133796377
prenatal oral development. 20133858029
[endometriosis in adolescent girls with developmental genital defects]. 20133592085
imaging metastases of thyroid carcinoma. 20133668671
initiating a community pharmacy residency. 20133728303
[is melanosis coli a harmless secondary finding?]. 20133960530
[is melanosis coli a harmless secondary finding?]. 20133960530
[from the national socialist time]. 20133774763
toward the elimination of guessing bias in landolt acuity testing.a subjective guessing bias has been claimed to be present in association with visual acuity testing using the classic circular landolt ring. a semiautomated visual test system has been described previously which uses an angular version of the broken ring. evidence is presented here which indicates that this version of the test object overcomes the problem of guessing bias and thus might prove to be not only a preferred "standard" or reference optotype but also an acceptable clinical optotype in ...20133777112
teniposide is not effective in chronic lymphocytic leukemia.teniposide has been evaluated in a phase ii clinical trial in chronic lymphocytic leukemia (cll). among 16 consecutive patients with cll entered in the study and treated with teniposide, 100 mg/m2 weekly, no objective response was observed. toxicity was generally mild and mainly hematologic. teniposide at this dosage and schedule is an inactive drug in cll.20133632912
discrepancies between the calculated digoxin clearance and the serum digoxin level in elderly patients. 20133662718
exercise thallium imaging in patients with diabetes mellitus. prognostic implications.we used exercise thallium 201 imaging in 123 patients with diabetes mellitus (77 men and 46 women, aged 56 +/- 8 years), 75% of whom had angina pectoris (typical or atypical). during exercise testing, 18 patients (15%) had angina pectoris, 28 (23%) had ischemic st changes, and 69 (56%) had abnormal thallium images. during follow-up (up to 36 months), there were 12 cardiac events; four patients died of cardiac causes and eight had nonfatal acute myocardial infarction. univariate and multivariate ...20133813750
neurotoxicity caused by lithium-verapamil synergism. 20133793965
[control of diabetes in the peroperative period using continuous intravenous insulin infusion with a pump]. 20133811779
[home life of the aged--psychological aspects].with increasing age the social and physical environment of elderly persons becomes increasingly focussed upon the home and its immediate surroundings, whilst life within the home ("wohnen") expands to take in a wider variety of activities. critical life events and transitions in old age often induce changes both in the way of life within the home and also in housing. the way of life of elderly people in the home ("alterswohnen") can be defined as the totality of goal-directed activities within t ...20133811468
occasions for cyclosporine in the management of various renal transplant situations. 20133893107
assessment of right and left heart interactions: application of the resistance ratio in chronic congestive heart failure. 20133779731
atracurium in clinical anaesthesia: effect of dosage on onset, duration and conditions for tracheal intubation.conditions for tracheal intubation at 90 seconds, time to onset of maximum block and duration of clinical relaxation after five different doses of atracurium, which ranged from 0.4 to 1.0 mg/kg were studied in 200 adult patients who were anaesthetized with nitrous oxide, oxygen and halothane or fentanyl. the conditions for intubation improved significantly with increasing doses, and were acceptable in 55% patients with a 0.4 mg/kg dose and in about 90% of those who received the two higher doses. ...20133839980
[various methods of the practical evaluation of functional possibilities of implanted synchronous cardiostimulators].some clinical device for the assessment of the sensitivity of the implanted demand-type cardiostimulator to bioelectric potentials are described. a relationship is demonstrated between the perception of bioelectric noise (muscular potentials) and sensitivity of the cardiostimulator.20133712949
an alternative view of education for deaf children: part i. 20133716955
[fetal uropathies. diagnostic and therapeutic problems].based on the experience of 63 antenatal diagnosis of fetal uropathies, the authors discuss the diagnostic problems, practical implications of antenatal diagnosis and potential indications of in utero interventions. a correct diagnosis was established in 43 out of the 63 cases (70%). diagnostic problems were encountered in differentiating between multicystic dysplastic kidneys and uretero-pelvic junction obstruction, dilatation due to reflux or from obstruction and from the lack of visualisation ...20133912074
myonecrosis, myoglobinuria and acute renal failure induced by south american rattlesnake (crotalus durissus terrificus) envenomation in brazil.the venom of the brazilian rattlesnake crotalus durissus terrificus is know to have hemolytic and neurotoxic physiopathological activities which may cause acute renal failure with hemoglobinuria and/or methemoglobinuria. as far as we know, no report has been published on the ability of the venom of this rattlesnake species to cause rhabdomyolysis. in the present paper we demonstrate that the venom of brazilian snakes of the genus crotalus can induce systemic myonecrosis. clinical, laboratory and ...20134060176
reliability, validity, and parent-child agreement studies of the diagnostic interview for children and adolescents (dica). 20133667494
[aneurysm of the ampulla of galen. anesthetic problems].anesthetic management of patients with arterio-venous malformations of the vein of galen needs to be adapted to the physiopathology of the affection. massive blood less before clipping and congestive heart failure after clipping may be avoided by using adequate transfusion and light arterial vasodilators preserving diastolic perfusion of the heart.20133683709
Refresh
firstprev
12345678910...
nextlast
Displaying items 101 - 200 of 1065