Publications

clinical characteristics and outcomes of patients with extended-spectrum β-lactamase-producing bacteremias in the emergency department.	extended-spectrum β-lactamase (esbl)-producing bacteria have been spreading from hospitals to communities. despite this, there are limited emergency department (ed) patient-based studies about these bacteremias. a retrospective matched case-control study with a ratio of 1:3 was conducted at a university hospital. the case group consisted of patients aged >16 years with esbl-producing bacteremias in the ed. patients matched for age and sex with non-esbl-producing bacteremias were sampled as the c ...	2011	22033790
Bactericidal properties of pradofloxacin against veterinary pathogens.	Pradofloxacin is a new veterinary 8-cyano-fluoroquinolone developed for use against bacterial infections in dogs and cats involving both aerobic and anaerobic bacteria. The minimal bactericidal concentrations have been determined against clinical isolates of Staphylococcus pseudintermedius, Staphylococcus aureus, Escherichia coli, Pasteurella multocida, Streptococcus canis, Proteus spp., Fusobacterium spp., Porphyromonas gingivalis and Prevotella species. A subset of these species was selected, ...	2011	22209121
[urinary tract infection in patient after brain injury].	intruduction: one of the most important problems in treating patients after head injury is urinary complication. the first place take urinary infections, which disturb rehabilitation process. clean intermittent catherization, bladder training and good care do not preserve infection. the purpose of our study was to present the frequency of urinary infections and main pathogens involved in these infections among patients treated in the department of rehabilitation after head injury.	2011	21812229
a computer-assisted diagnostic and treatment concept to increase accuracy and safety in the extracranial correction of cranial vault asymmetries.	purpose: proteus syndrome is described as a progressive, asymmetric, disproportional overgrowth of various parts of the body. the theory of somatic mosaicism is widely accepted to be the cause of this disease. affected patients present very heterogeneous symptoms, but in about 30% craniofacial deformities are the leading clinical features. because no causal therapy exists, treatment options are limited to surgical improvement of functional constraints. materials and methods: a computer-assisted ...	2011	21807449
proteus syndrome: a medical rarity.		2011	21804811
synthesis, characterization, theoretical crystal structure, and antibacterial activities of some transition metal complexes of the thiosemicarbazone (z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide.	problem statement. in iraq like most third world countries, attempts discovered new antibiotic drugs derived from thiosemicarbazide and its metal complexes and developed the branch of applied in organic chemistry. approach. new (z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (l) was synthesized in a good yield by the reaction of pyrrolidone with thiosemicarbazide. co(ii), ni(ii), and cu(ii) complexes of (l) were prepared and characterized by ft-ir, uv/visible spectra, (1)hnmr, and chn analys ...	2011	21804771
giant chondrolipoma of the tongue in a 14-year-old child with mandibular hypertrophy. isolated lesion or regional overgrowth syndrome.	chondrolipoma is a rare condition; especially in the oral cavity. the authors described a giant chondrolipoma of the tongue, associated with mandibular and lower lip overgrowth, in a 14-year-old boy. after tumour excision, histopathological examination showed mature cartilage within lobules of mature adipocytes. this is the first case of giant chondrolipoma associated with facial overgrowth. the aetiology and the association with a localized proteus syndrome are discussed.	2011	21802258
in vitro antimicrobial and antioxidant activity of acetone and methanol extracts from thymus leucotrichius (lamiaceae).	thymus species has been used as tonic and herbal tea, antiseptic, antitussive, carminative, antioxidant, anti-inflammatory and antimicrobial activities. the acetone and methanol extracts of thymus (t.) leucotrichius (labiatae/lamiaceae) was examined for antimicrobial and antioxidant properties.	2011	21796869
detection of the staphylococcal multiresistance gene cfr in proteus vulgaris of food animal origin.	objectives to investigate the presence and the genetic environment of the multiresistance gene cfr in naturally occurring gram-negative bacteria of pigs. methods a total of 391 bacterial isolates with florfenicol mics of =16 mg/l, obtained from 557 nasal swabs of individual pigs, were screened by pcr for the known florfenicol resistance genes. the species assignment of the cfr-carrying isolate was based on the results of gram's staining, colony morphology, 16s rdna sequencing and biochemical pro ...	2011	21795256
synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities.	a series of novel fluconazoliums were synthesized and their bioactive evaluation as potential antibacterial and antifungal agents were described. some target compounds displayed good and broad-spectrum antimicrobial activities with low mic values ranging from 0.25 to 64 µg/ml against all the tested strains, including three gram-positive bacteria (staphylococcus aureus, mrsa and bacillus subtilis), three gram-negative bacteria (escherichia coli, pseudomonas aeruginosa and bacillus proteus) as wel ...	2011	21794961
synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents.	a series of novel s-triazine analogs were synthesized and characterized by ir, (1)h nmr, (13)c nmr, (19)f nmr spectroscopy and elemental analysis. preliminary screening of target compounds against eight bacteria (staphylococcus aureus, bacillus cereus, escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae, salmonella typhi, proteus vulgaris, shigella flexneria), four fungi (aspergillus niger, aspergillus fumigatus, aspergillus clavatus, candida albicans) and mycobacterium tuberculosis ...	2011	21794959
a mosaic activating mutation in akt1 associated with the proteus syndrome.	background the proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. it has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state. methods we performed exome sequencing of dna from biopsy samples obtained from patients with the proteus syndrome and compared the resultant dna sequences with those of unaffected tissues obtained from the same patients. we confirmed and extended an o ...	2011	21793738
hamartoma syndromes, exome sequencing, and a protean puzzle.	gross malformations have been well known for centuries, even millennia. however, it was not until 1904 that albrecht coined the concept of hamartoma. in 1934, the concept entered the field of developmental pathology generally in reference to tissue malformations. hamartomata are localized overgrowths of a single tissue or combination of tissues, indigenous to the affected body part or organ, usually growing at the same rate as the normal components and causing little pain or functional impairmen ...	2011	21793737
new delhi metallo-ss-lactamase-1: detection and prevention.		2011	21788418
chemical composition and antimicrobial activity of the essential oil of rosemary.	the composition of the essential oil of rosemary was analyzed by gas chromatography-mass spectrometry (gc-ms). 22 components, which constitute 97.41% of the oil, were identified. the major constituents were 1,8-cineole (26.54%) and a-pinene (20.14%). minimum inhibitory concentrations (mics), minimal bactericidal concentration (mbc) and time-kill dynamic processes against three gram-positive bacteria (staphylococcus epidermidis, staphylococcus aureus and bacillus subtilis), three gram-negative ba ...	2011	21787731
new inhibitors of colony spreading in bacillus subtilis and bacillus anthracis.	we have recently characterized sliding motility in bacillus subtilis strains that lack functional flagella, and here describe the discovery of inhibitors of colony spreading in these strains as well as the aflagellate pathogen, bacillus anthracis. aflagellate b. subtilis strains were used to screen for new types of antibacterials that might inhibit colony spreading on semi-solid media. from a diverse set of organic structures, p-nitrophenylglycerol (npg), an agent used primarily in clinical labo ...	2011	21784632
[clinical and economic expedience of ertapenem therapy of complicated urinary tract infection].	clinical and economic investigation of various antibiotics use in the treatment of complicated urinary tract infection (cuti) was performed under the russian economic environment. the drugs of comparison were ertapenem, ceftriaxone and levofloxacin. direct costs and their structure were shown, and the cost efficiency was calculated. alternative analysis and one-side susceptibility analysis were performed. in complicated urinary tract infections when the major pathogens were escherichia coli, kle ...	2011	21780670
[proteus mirabilis isolated from urine, resistance to antibiotics and biofilm formation].	in the rather rare urinary pathogen proteus mirabilis resistance to antibiotics and ability to form biofilm were studied.	2011	21780025
antibacterial activity of selected ethnomedicinal plants from south india.	to screen the antimicrobial potential of three ethnomedicinal plants chassalia curviflora thw. (c. curviflora), cyclea peltata hook. f. & thomson (c. peltata) and euphorbia hirta l (e. hirta) used in folk medicines in aarukani hills kani tribe, tamil nadu, india against human bacterial pathogens.	2011	21771680
antibacterial activity of leaves and inter-nodal callus extracts of mentha arvensis l.	to determine the anti-bacterial efficacy of chloroform, ethanol, ethyl acetate and water extracts of inter-nodal and leaves derived calli extracts from mentha arvensis (m. arvensis) against salmonella typhi(s. typhi), streptococcus pyogenes(s. pyogenes), proteus vulgaris(p. vulgaris) and bacillus subtilis(b. subtilis).	2011	21771452
carbon nanoparticles-assisted mediator-less microbial fuel cells using proteus vulgaris.	recently mediator-less microbial fuel cells (mfcs) are attracting great interest among researchers due to their potential applications to electricity generation as well as wastewater treatment. common mediator-less mfcs employ electroactive bacteria called exoelectrogens to directly transfer electrons to the anode from the bacteria. however, exoelectrogens are rather limited in number and thus may not find general use for practical purposes. here we showed our results in which mediator-less mfcs ...	2011	21764289
comprehensive inhibitor profiling of the proteus mirabilis metalloprotease virulence factor zapa (mirabilysin).	in this study we report for the first time the comprehensive inhibitor profiling of the proteus mirabilis metalloprotease virulence factor zapa (mirabilysin) using a 160 compound focused library of n-alpha mercaptoamide dipeptides, in order to map the s(1)(') and s(2)(') binding site preferences of this important enzyme. this study has revealed a preference for the aromatic residues tyrosine and tryptophan in p(1)(') and aliphatic residues in p(2)('). from this library, six compounds were identi ...	2011	21762758
susceptibility of esbl-producing enterobacteriaceae with the new clsi breakpoints.	in 2010 clsi lowered the susceptibility breakpoints of some cephalosporins and aztreonam for enterobacteriaceae and eliminated the need to perform esbl screening and confirmatory tests. the aim of this study was to determine how many esbl-producing strains will test susceptible for three common species of enterobacteriaceae using the new breakpoints. as determined with the clsi screening and confirmatory tests, 382 consecutive esbl-producing strains were collected at our hospital between 2007 an ...	2011	21752977
prevalence of sxt/r391-like integrative and conjugative elements carrying blacmy-2 in proteus mirabilis.	objectives to characterize the vectors involved in the dissemination of bla(cmy-2) genes in clinical isolates of proteus mirabilis collected between 1999 and 2007. methods plasmid analysis of 19 p. mirabilis carrying ampc genes was performed by pcr-based replicon typing, s1-pfge and southern hybridization with ampc and replicon probes. isolates that could not be characterized were examined for the presence of sxt/r391-like elements. to demonstrate the involvement of these elements in the dissemi ...	2011	21752830
microbiology at first visit of moderate-to-severe diabetic foot infection with antimicrobial activity and a survey of quinolone monotherapy.	samples from 1295 patients with diabetic foot infection were evaluated; 4332 samples were collected with an average of 3.3 samples per patient. fifty-seven percent of patients had a 2b ulcer and 23% had a 3b ulcer according to texas university classification. in 64.2% of samples collected at first visit an etiologic agent was identified. about 40% of the positive samples were polymicrobial. gram positive bacteria were more frequently isolated (52.6%), staphylococcus aureus was the most frequentl ...	2011	21824673
microbiological profile with antibiotic sensitivity pattern of cholesteatomatous chronic suppurative otitis media among children.	chronic suppurative otitis media (csom) is the most common cause of childhood hearing impairment in the developing countries and atticoantral type is associated with increased incidence of intracranial and extracranial complications. this study was undertaken to define the microbiology of atticoantral type of chronic otitis media and the antibiotic sensitivity pattern, thereby reducing the potential risks of complications.	2011	21715027
composition and antimicrobial activity of achillea distans essential oil.	the essential oil of achillea distans w. et k. flower heads was analyzed by gc and gc-ms. altogether 43 components in concentrations more than 0.1% were identified representing 93.5% of the oil composition. the main constituents were 1,8-cineole (16.8%), trans-thujone (9.8%), sabinene (8.2%), borneol (7.5%), beta-pinene (6.5%), and camphor (5.8%). the oil showed moderate activity against staphylococcus aureus and candida albicans, and weak activity against salmonella typhimurium, proteus vulgari ...	2011	21815436
purple urine.		2011	21738253
antimicrobial activity of two essential oils.	the aim of the study was to evaluate the antimicrobial activity of essential oils in vitro for possible application to reduce the content of microorganisms in the air of animal houses. the essential oils of cymbopogon citrarus l. and malaleuca alternifolia l. were screened against bacteria staphylococcus aureus, enterococcus faecium, pseudomonas aeruginosa, escherichia coli, proteus mirabilis and yeast candida albicans. the minimal inhibitory concentration of the active essential oils was tested ...	2011	21739934
a new class of 2-(4-cyanophenyl amino)-4-(6-bromo-4-quinolinyloxy)-6-piperazinyl (piperidinyl)-1,3,5-triazine analogues with antimicrobial/antimycobacterial activity.	this study presents the synthesis and in vitro pharmacological evaluations of novel 2-(4-cyanophenyl amino)-4-(6-bromo-4-quinolinyloxy)-6-piperazinyl (piperidinyl)-1,3,5-triazines. the title compounds were assayed for their in vitro antimicrobial activity against eight bacteria (staphylococcus aureus, bacillus cereus, escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae, salmonella typhi, proteus vulgaris, shigella flexneria) and four fungi (aspergillus niger, aspergillus fumigatus, a ...	2011	21740100
surface microbial consortia from livarot, a french smear-ripened cheese.	the surface microflora (902 isolates) of livarot cheeses from three dairies was investigated during ripening. yeasts were mainly identified by fourier transform infrared spectroscopy. geotrichum candidum was the dominating yeast among 10 species. bacteria were identified using biotype 100 strips, dereplicated by repetitive extragenic palindromic pcr (rep-pcr); 156 representative strains were identified by either box-pcr or (gtg)(5)-pcr, and when appropriate by 16s rdna sequencing and sds-page an ...	2011	21815832
evaluation of efficacy of topical povidone-iodine and different types of fluoroquinolones in the sterilization of bacterial flora on the conjunctiva.	abstract purpose: to compare the sterilization effectivity of topical povidone-iodine, ciprofloxacin, and ofloxacin on the conjunctival bacterial flora. methods: one hundred sixty-four eyes of 164 patients scheduled for cataract surgery were prospectively analyzed. conjunctival cultures were obtained 1 day before the surgery without any topical application in all patients. conjunctival flora was examined in 53 eyes of 53 patients (group i) 15ôçëmin after 5% topical povidone-iodine application on ...	2011	21834670
antimicrobial resistance patterns of uropathogens among children in istanbul, turkey.	urinary tract infections are a common cause of end-stage renal disease in turkey. this prospective study investigated the antibiotic resistance patterns of uropathogens in order to recommend appropriate therapeutic protocols for children with urinary tract infections in istanbul, turkey. between october 2007 and october 2008, children presenting with a first episode of urinary tract infection to a pediatric outpatient clinic were enrolled in the study. urine samples were cultured, and antimicrob ...	2011	21710858
acidic environments induce differentiation of proteus mirabilis into swarmer morphotypes.	although swarmer morphotypes of proteus mirabilis have long been considered to result from surfaced-induced differentiation, the present findings show that, in broth medium containing urea, acidic conditions transform some swimmer cells into elongated swarmer cells. this study has also demonstrates that p. mirabilis cells grown in acidic broth medium containing urea enhance virulence factors such as flagella production and cytotoxicity to human bladder carcinoma cell line t24, though no signific ...	2011	21707738
[russian results of the international epidemiological study of clinical aspects and resistance to antimicrobial medicines of cystitis uropathogens in females (aresc): significance of empiric therapy].	a total of 656 female patients from russia aged between 18 to 65 years with uncomplicated cystitis entered the international aresc trial, of them 647 were eligible for final analysis. positive cultural urine tests ( > 10(4) cfu/ml) were in 419 (64.7%) patients, 393 (93.8%) patients had monoinfection. the central laboratory of genoa (to which the isolated samples were sent) has tested 416 uropathogens from 399 patients. the following pathogens were isolated: e. coli (72.6%), enterococcus (7.0%), ...	2011	21815455
detection of volatile compounds produced by microbial growth in urine by selected ion flow tube mass spectrometry (sift-ms).	selected ion flow tube-mass spectrometry has been used to measure the volatile compounds occurring in the headspace of urine samples inoculated with common urinary tract infection (uti)-causing microbes escherichia coli, proteus vulgaris, pseudomonas aeruginosa, staphylococcus aureus, staphylococcus epidermidis, klebsiella pneumoniae, enterococcus faecalis, or candida albicans. this technique has the potential to offer rapid and simple diagnosis of the causative agent of utis.	2011	21741416
investigation of the antimicrobial activity of rhaponticum (rhaponticum carthamoides d.c. iljin) and shrubby cinquefoil (potentilla fruticosa l.).	the aim of the study was to determine antimicrobial activity of rhaponticum and shrubby cinquefoil extracts. material and methods. ethanol extract from the leaves of rhaponticum (rhaponticum carthamoides d.c. iljin) and shrubby cinquefoil (potentilla fruticosa l.) was produced at the department of food technology, kaunas university of technology. the antimicrobial activity of the viscous extract or rhaponticum and shrubby cinquefoil was evaluated using standard microorganism cultures (bacteria s ...	2011	21822040
Cerebriform Plantar Hyperplasia: The Clinico-pathological Hallmark of Proteus Syndrome.		2011	21681363
Macrodactyly with skin hypertrophy: a minimal form of the Proteus syndrome.	The Proteus syndrome was described 1983 . It has asymmetric gigantism of the limbs, verrucous epidermal naevi, cerebriform enlargement of the plantar region, vascular malformations and neoplasms, as lipomas. It received this denomination after Proteus from the Greek mythology, who had the ability to change his form . A 15 year-old boy, reported a congenital hypertrophy with syndactily of the second and third right fingers . The second case is a 35 year-old man, who reported that since birth the ...	2011	21738976
Trimethoprim/sulfametrole: evaluation of the available clinical and pharmacokinetic/pharmacodynamic evidence.	Emergence of resistance to widely used trimethoprim/sulfamethoxazole (TMP/SMX) as well as common adverse events in human immunodeficiency virus (HIV)-infected patients casts interest on combinations of TMP with other sulfonamides. Sulfametrole (SMT) combined with TMP could provide a choice for difficult-to-treat infections, particularly when administered intravenously. The objective of this review was to evaluate the available clinical and pharmacokinetic/pharmacodynamic (PK/PD) evidence regardi ...	2011	21741802
relationship between chemical structure and biological activity of alkali metal o-, m- and p-anisates. ft-ir and microbiological studies.	in this work we investigated relationship between molecular structure of alkali metal o-, m-, p-anisate molecules and their antimicrobial activity. for this purpose ft-ir spectra for lithium, sodium, potassium, rubidium and caesium anisates in solid state and solution were recorded, assigned and analysed. microbial activity of studied compounds was tested against escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and proteus vulgaris. in order to evaluate the dependency between chem ...	2011	21852187
the antimicrobial efficacy of silver on antibiotic-resistant bacteria isolated from burn wounds.	the antibiotic-resistant bacteria are a major concern to wound care because of their ability to resist many of the antibiotics used today to treat infections. consequently, other antimicrobials, in particular ionic silver, are considered ideal topical agents for effectively helping to manage and prevent local infections. little is known about the antimicrobial efficacy of ionic silver on antibiotic-resistant bacteria at different ph values. consequently, in this study our aim was to evaluate the ...	2011	22182219
vim and imp metallo-β-lactamases and other extended-spectrum β-lactamases in escherichia coli and klebsiella pneumoniae from environmental samples in a tunisian hospital.	an extremely drug-resistant enterobacteriaceae species emerged in kasserine hospital, tunisia between 2009 and 2010 causing a local outbreak. we aimed to characterize extended-spectrum β-lactamase (esbl) and metallo-β-lactamase (mbl)-producing enterobacteriaceae from the hospital environment. swabs were collected from ten different wards from kasserine hospital, tunisia. a total of 46 isolates were cultured onto macconkey agar supplemented with ceftazidime to select for esbl-producing enterobact ...	2011	21917010
Development of an antibiogram in a long-term care facility.	To create an antibiogram-a profile of an organism's susceptibility/resistance to a panel of antibiotics- for a long-term care facility to assess the prevalence of resistance of bacteria present at the facility.	2011	22079792
Antimicrobial susceptibility of Gram-negative organisms from intraabdominal infections and evolution of isolates with extended spectrum ß-lactamases in the SMART study in Spain (2002-2010).	Introduction. The SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study records the antimicrobial susceptibility of Gram-negative bacilli obtain from intraabdominal infections with special focus in isolates with extended spectrum ß-lactamases (ESBLs). Material and Methods. The antimicrobial susceptibility of 8,869 isolates was analyzed by microdilution during the SMART study performed in Spain from 2002 to 2010. Isolates were recovered in 16 centres. Results. Escherichi ...	2011	22173194
Origins of the elephant man: mosaic somatic mutations cause Proteus syndrome.		2011	22035467
[Synthesis and antimicrobial evaluation of coumarin-based benzotriazoles and their synergistic effects with chloromycin and fluconazole].	A series of new coumarin-based benzotriazole derivatives were successfully synthesized via a multi-step sequence of cyclization, etherification and N-alkylation, and were confirmed by 1H NMR, IR, MS spectra as well as elemental analyses. All these synthesized coumarin compounds were evaluated for in vitro antimicrobial activities against four Gram-positive bacteria, four Gram-negative bacteria and three fungi by two fold serial dilution technique. The bioactive assay showed that all these prepar ...	2011	22010349
[etiology and sensitivity of uropathogens identified in uncomplicated lower urinary tract infections in women (aresc study): implications on empiric therapy].	to determine the etiology and susceptibility of uropathogens identified in women with uncomplicated lower urinary tract infections (uti).	2011	20889171
neurofibromatosis type 1: persisting misidentification of the "elephant man" disease.	during informal interviews in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents, many members of canadian neurofibromatosis associations have stated that they continue to be told the condition that afflicts them or their children is "elephant man's disease." today, even though well-established clinical criteria make it possible to diagnose and differentiate the 2 diseases, the confusion between neurofibromatosis type 1 ...	2011	21209351
efficient secretion of biologically active chondroitinase abc from mammalian cells in the absence of an n-terminal signal peptide.	proteoglycans carrying chondroitin sulfate side chains have been shown to fulfill important biological functions in development, disease, and signaling. one area of considerable interest is the functional importance of chondroitin sulfates as inhibitors of the regeneration of axonal projections in the mammalian central nervous system. in animal models of spinal cord injury, injections of the enzyme chondroitinase abc from the bacterium proteus vulgaris into the lesion site leads to degradation o ...	2011	21213020
volatile compounds and antimicrobial and antioxidant activities of the essential oils of the needles of pinus densiflora and pinus thunbergii.	to investigate the volatile compounds and the antibacterial and antioxidant effects of the essential oils of pinus densiflora needles (epdn) and pinus thunbergii needles (eptn), the volatile compounds of steam-distilled essential oils were analysed by gas chromatography-mass spectrometry. antibacterial activities were analysed by performing disc-agar diffusion assay and determining the minimum inhibitory concentrations (mics) of the essential oils. antioxidant activities were analysed via radica ...	2011	21213230
idiopathic corporeal hemihypertrophy associated with hemihypertrichosis.	the hemihypertrophy or hemihyperplasy is a rare congenital abnormality, characterized by an asymmetric growth of the limbs, the trunk, and the face or half of the entire body. it may be isolated or be part of several syndromes including beckwith-wiedemann syndrome, klippel-trenaunay-weber syndrome, silver-russell syndrome and proteus syndrome. in its isolated form, it is called idiopathic. the latter may be associated with several anomalies including dermatological and urogenital abnormalities w ...	2011	21232734
carijodienone from the octocoral carijoa multiflora. a spiropregnane-based steroid.	two new steroids (1 and 2) and the known pregna-1,4,20-trien-3-one (3) have been isolated from the pacific octocoral carijoa multiflora. compound 1 possesses a novel spiropregnane-based steroidal skeleton. the photochemical transformation of 3 into 1 allowed the assignment of the absolute configuration at c-10 of 1. the antibacterial activities of compounds 1 and 3 were evaluated against a panel of bacterial strains.	2011	21235217
treatment of endocarditis due to proteus species: a literature review.	endocarditis due to proteus species is very rare. we report a case of endocarditis due to proteus mirabilis that was successfully treated with ampicillin and gentamicin, and review the treatment regimens of previously published cases of proteus endocarditis.	2011	21237686
suprathel-antiseptic matrix: in vitro model for local antiseptic treatment?	acetic acid is a traditional antiseptic agent that has been used for more than 6000 years. the main goal of this study was to demonstrate the suitability of suprathel (polymedics innovations gmbh, denkendorf, germany) in combination with various antiseptic agents to create an "antiseptic-matrix" especially designed for problematic microorganisms such as proteus vulgaris, acinetobacter baumannii, or pseudomonas aeruginosa, which are frequently associated with burns. the study was designed to test ...	2011	21242734
enterobacterial microflora in infancy - a case study with enhanced enrichment.	to validate pmeu (portable microbe enrichment unit) method for monitoring the composition and development of infantile intestinal enterobacterial microflora.	2011	21249478
influence of referral bias on the clinical characteristics of patients with gram-negative bloodstream infection.	summaryreferral bias can influence the results of studies performed at tertiary-care centres. in this study, we evaluated demographic and microbiological factors that influenced referral of patients with gram-negative bloodstream infection (bsi). we identified 2919 and 846 unique patients with gram-negative bsi in a referral cohort of patients treated at mayo clinic hospitals and a population-based cohort of olmsted county, minnesota, residents between 1 january 1998 and 31 december 2007, respec ...	2011	21281552
chromosome-encoded ampc and ctx-m extended-spectrum ß-lactamases in clinical isolates of proteus mirabilis from korea.	among 222 proteus mirabilis clinical isolates collected from 17 hospitals in korea in 2008, 28 (12.6%) and 8 (3.6%) isolates exhibited extended-spectrum ß-lactamase (esbl) and ampc phenotypes, respectively. the most common type of esbl gene identified by pcr and sequencing experiments was bla(ctx-m-14a) (n = 12). the bla(ctx-m-90) (n = 4), bla(ctx-m-15) (n = 3), bla(ctx-m-12) (n = 3), bla(ctx-m-2) (n = 2), bla(ctx-m-14b) (n = 1), bla(tem-52) (n = 5), and bla(shv-12) (n = 1) genes were also detec ...	2011	21282448
the free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan.	recent work on a small european cave salamander (proteus anguinus) has revealed that it has exceptional longevity, yet it appears to have unexceptional defences against oxidative damage. this paper comes at the end of a string of other studies that are calling into question the free-radical damage theory of ageing. this theory rose to prominence in the 1990s as the dominant theory for why we age and die. despite substantial correlative evidence to support it, studies in the last five years have ...	2011	21290398
prevalence and phenotypic characterisation of carbapenem resistance in enterobacteriaceae bloodstream isolates in a tertiary care hospital in india.		2011	21295949
expression and characterization of a second l-amino acid deaminase isolated from proteus mirabilis in escherichia coli.	l-amino acid deaminases catalyze the deamination of natural l-amino acids. two types of l-amino acid deaminase have been identified in proteus species. one exhibits high levels of activity toward a wide range of aliphatic and aromatic l-amino acids, typically l-phenylalanine, whereas the other acts on a relatively narrow range of basic l-amino acids, typically l-histidine. in this study, we cloned, expressed, and characterized a second amino acid deaminase, termed pm1, from p. mirabilis kctc 256 ...	2011	21298676
antibacterial activity of the indigenous earthworms lampito mauritii (kinberg) and perionyx excavatus (perrier).	earthworms respond to microbial infection through cellular and humoral defense mechanisms such as antimicrobial protein secretions. most of the humoral defense proteins are synthesized in the skin itself.	2011	21299431
thrombocytes are effectors of the innate immune system releasing human beta defensin-3.	thrombocyte concentrate i.e. platelet-rich plasma (prp) has become a popular adjunct for many surgical procedures. it is believed to improve bone and soft tissue healing. recently antimicrobial effects of the autologous preparation were reported by several groups. in this study we investigated the antimicrobial effect of prp against gram-negative microbes which frequently cause severe complications in orthopaedic trauma surgery.	2011	21310405
production of biogenic amines by lactic acid bacteria and enterobacteria isolated from fresh pork sausages packaged in different atmospheres and kept under refrigeration.	the occurrence of in vitro amino acid activity in bacterial strains associated with fresh pork sausages packaged in different atmospheres and kept in refrigeration was studied. the presence of biogenic amines in decarboxylase broth was confirmed by ion-exchange chromatography and by the presence of the corresponding decarboxylase genes by pcr. from the 93 lactic acid bacteria and 100 enterobacteria strains analysed, the decarboxylase medium underestimates the number of biogenic amine-producer st ...	2011	21316866
clinical, immunological and genetic features in taiwanese patients with the phenotype of hyper-immunoglobulin e recurrent infection syndromes (hies).	hyper-immunoglobulin e recurrent infection syndromes (hies) have distinct features, with identified associated mutations of stat3, tyk2, and dock8. among 197 taiwanese patients with primary immunodeficiency on a referral-base of over 23 million inhabitants, stat3 (r382w and q469r) and dock8 mutations (exon 1-9 deletion) were identified in two patients each from six ad-hies and five ar-hies patients, respectively. aside from decreased th17 and memory b cells, characteristic facies and pneumatocel ...	2011	21324546
[one-stage revision of knee endoprosthesis due to periprosthetic infection and klippel-trenaunay syndrome].	we present the case of a patient with klippel-trenaunay syndrome (kts) who underwent a one-stage revision of an infected total knee arthroplasty. a detailed orthopedic description of kt is presented as well as a discussion on the implementation of one-stage or multi-stage revision following infections of total knee arthroplasty. due to vascular anomalies with severe coagulation problems, soft tissue swelling and increased risk of infection, surgical treatment of such patients presents a special ...	2011	21327613
isolation of a selected microbial consortium capable of degrading methyl parathion and p-nitrophenol from a contaminated soil site.	a bacterial consortium with the ability to degrade methyl parathion and p-nitrophenol, using these compounds as the only carbon source, was obtained by selective enrichment in a medium with methyl parathion. samples were taken from moravia, medellin; an area that is highly contaminated, owing to the fact that it was used as a garbage dump from 1974 to 1982. acinetobacter sp, pseudomonas putida, bacillus sp, pseudomonas aeruginosa citrobacter freundii, stenotrophomonas sp, flavobacterium sp, prot ...	2011	21328125
antimicrobial activity of erythromycin and clarithromycin against clinical isolates of escherichia coli, staphylococcus aureus, klebsiella and proteus by disc diffusion method.	fifty clinical isolates comprising of escherichia coli, staphylococcus aureus, klebsiella and proteus were collected from different local pathological laboratories and their resistant pattern against two well known macrolides; erythromycin and clarithromycin were studied using disc diffusion method. klebsiella (41.67% against erythromycin and 58.34% against clarithromycin) and proteus (66.67% against erythromycin and clarithromycin) species were found to be more resistant against the studied mac ...	2011	21190914
[nosocomial sinusitis in an intensive care unit: a microbiological study].	nosocomial sinusitis is a common complication of patients in icus. its diagnosis is important, and early treatment is required to avoid serious complications such as pneumonia, sepsis, meningitis, and intracranial abscesses.	2011	21340197
scalarane sesterterpenes from the sponge hyatella sp.	five new sesterterpenes (7-11) along with six known compounds (1-6) were isolated from the sponge hyatella sp., collected off the coast of soheuksan-do, korea. spectroscopic analyses revealed these compounds as scalarane sesterterpenes with oxidized furan moieties (7-10) and a corresponding lactam (11). the compounds exhibited moderate cytotoxicity, antibacterial activity, and weak inhibitory activity against isocitrate lyase.	2011	21341710
neurofibromatosis type 1 and the "elephant man's" disease: the confusion persists: an ethnographic study.	during informal interviews in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents, many members of canadian neurofibromatosis associations stated they continue to be told the condition that afflicts them or their children is the "elephant man's" disease. today, even though well established clinical criteria make it possible to diagnose and differentiate the two diseases, the confusion between nf1 and the disease of joseph ...	2011	21347399
broad-spectrum antimicrobial efficacy of peptide a3-apo in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved.	although the designer proline-rich antimicrobial peptide a3-apo has only modest activity against escherichia coli and acinetobacter baumannii in vitro, in mouse models of systemic and wound infections it shows superior efficacy compared with conventional antibiotics. in this study, the efficacy of a3-apo in several additional mouse models was investigated, including staphylococcus aureus wound infection, mixed klebsiella pneumoniae-a. baumannii-proteus mirabilis wound infection and k. pneumoniae ...	2011	21353493
in vitro activity of ceftobiprole against frequently encountered aerobic and facultative gram-positive and gram-negative bacterial pathogens: results of the canward 2007-2009 study.	the in vitro activity of ceftobiprole was evaluated against 15 011 clinical isolates obtained from patients in canadian hospitals between 2007 and 2009. all staphylococcus aureus were susceptible to ceftobiprole (mic(90)'s for methicillin-susceptible staphylococcus aureus and methicillin-resistant staphylococcus aureus of = 1 µg/ml and 2 µg/ml, respectively). ceftobiprole was active against penicillin-susceptible streptococcus pneumoniae (mic(90), = 0.06 µg/ml), penicillin-resistant streptococcu ...	2011	21353964
confirmation of hiv-like sequences in respiratory tract bacteria of cambodian and kenyan hiv-positive pediatric patients.	bacteria and yeasts isolated from respiratory tracts of 39 cambodian and 28 kenyan hiv-positive children were tested for the presence of hiv-1 sequences.	2011	21358602
chemical composition and antimicrobial activity of the essential oil of the leaves of feronia elephantum (rutaceae) from north west karnataka.	the essential oil of the leaves of feronia elephantum corr. was analyzed by gas chromatography and gas chromatography/mass spectrometry. the main constituents were beta-pinene (28.4%), z-anethole (22.1%), methyl chavicol (12.0%) and e-anethole (8.1%), among thirty-three identified compounds, which represented 92.6% of the total oil. the antimicrobial activity was tested against five gram-positive and eight gram-negative bacteria, and four fungi. the oil was active against micrococcus luteus (gra ...	2011	21366066
in vitro synthesis of biogenic amines by brochothrix thermosphacta isolates from meat and meat products and the influence of other microorganisms.	twenty brochothrix thermosphacta strains tested for biogenic amines (bas) production, formed histamine (6.6-16.2 mg/kg) and tyramine (18.7-35.4 mg/kg) but neither putrescine nor cadaverine. six of the twenty strains were also investigated in respect of their influence on the synthesis of bas by escherichia coli, pseudomonas sp., proteus mirabilis and lactobacillus sakei. in pure culture escherichia coli produced all of the studied amines (histamine, tyramine, putrescine and cadaverine) with a to ...	2011	21382674
cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids.	some natural products consisting of the alkaloids yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type); the flavonoid derivatives quercetin, apigenin, genistein, naringin, silymarin, and silibinin; and the phenolic acids namely gallic acid, caffeic acid, chlorogenic acid, and quinic acid, were tested for their ...	2011	21391841
new variant salmonella genomic island 1-u in proteus mirabilis clinical and food isolates from south china.		2011	21393148
evaluation of antimicrobial susceptibility for +¦-lactams against clinical isolates from 51 medical centers in japan (2008).	this antimicrobial resistance surveillance study was performed in 51 medical centers in japan over an 11-year period. the susceptibilities of 4228 strains including escherichia coli (491 strains), klebsiella spp. (462 strains), enterobacter spp. (459 strains), citrobacter freundii (358 strains), indole-positive proteus spp. (386 strains), serratia spp. (443 strains), acinetobacter spp. (327 strains), pseudomonas aeruginosa (473 strains), oxacillin-susceptible staphylococcus aureus (481 strains), ...	2011	21396543
relationship between the camp levels in leukocytes and the cytokine balance in patients surviving gram negative bacterial pneumonia.	lipopolysaccharide-stimulated leukocytes secrete proinflammatory cytokines including tumor necrosis factor-a and interleukin-12. over-activation of host defense systems may result in severe tissue damage and requires regulation. granulocyte colony-stimulating factor and interleukin-10 are candidate cytokines for inducing tolerance to lipopolysaccharide re-stimulation. we compared cytokines secreted by lipopolysaccharide-stimulated blood cells from patients who had survived gram negative bacteria ...	2011	21373266
in vitro activity of ceftaroline against gram-positive and gram-negative pathogens isolated from patients in canadian hospitals in 2009.	the in vitro activities of ceftaroline and comparative agents were determined for a collection of the most frequently isolated bacterial pathogens from hospital-associated patients across canada in 2009 as part of the ongoing canward surveillance study. in total, 4,546 isolates from 15 sentinel canadian hospital laboratories were tested using the clinical and laboratory standards institute (clsi) broth microdilution method. compared with other cephalosporins, including ceftobiprole, cefepime, an ...	2011	21402844
evolution and spread of a multidrug-resistant proteus mirabilis clone with chromosomal ampc-type cephalosporinases in europe.	proteus mirabilis isolates obtained in 1999 to 2008 from three european countries were analyzed; all carried chromosomal ampc-type cephalosporinase bla(cmy) genes from a citrobacter freundii origin (bla(cmy-2)-like genes). isolates from poland harbored several bla(cmy) genes (bla(cmy-4), bla(cmy-12), bla(cmy-14), bla(cmy-15), and bla(cmy-38) and the new gene bla(cmy-45)), while isolates from italy and greece harbored bla(cmy-16) only. earlier isolates with bla(cmy-4) or bla(cmy-12), recovered in ...	2011	21402851
ß-lactamase producing enterobacteria isolated from surveillance swabs of patients in a cardiac intensive care unit in rio de janeiro, brazil.	there is a high incidence of infections caused by betalactamase-producing gram-negative microorganisms in brazil. these organisms are of clinical and epidemiological importance, since their mobile genetic elements facilitate cross-infection. the present study was conducted in sentinel rectal swabs from patients admitted to a cardiac surgery hospital in rio de janeiro, from january through december 2007, in a consecutive manner. the aim of the study was to characterize the genotype and phenotype ...	2011	21412586
pulmonary manifestations in proteus syndrome: pulmonary varicosities and bullous lung disease.	we report on two patients with proteus syndrome (ps), with emphasis on its pulmonary manifestations. the first patient was a 6-year-old girl diagnosed with ps at 5 years of age. the pulmonary abnormalities first observed at age 3 years and included streaky densities with accentuated vascular markings detected by chest radiography. the patient had persistent abnormalities on follow-up chest radiographs. chest computed tomography (ct) scans showed diffuse pulmonary venous dilatations. the second p ...	2011	21412980
nasal immunization with attenuated salmonella typhimurium expressing an mrpa-tetc fusion protein significantly reduces proteus mirabilis colonization in the mouse urinary tract.	the development of effective strategies to prevent urinary tract infections (utis) has become an important goal in public health. proteus mirabilis is commonly associated with complicated utis and expresses several virulence factors, including mannose-resistant proteus-like (mr/p) fimbriae. here, a fusion protein formed from mrpa, the structural protein of mr/p fimbriae, and tetc, a non-toxic but highly immunogenic fragment of tetanus toxin, to be delivered by an attenuated salmonella typhimuriu ...	2011	21415205
an unusual initial presentation of proteus syndrome: macrosyndactyly.	proteus syndrome is a complex disorder characterized by a wide variety of deformities including macrodactyly. in the present report, we present a case with complex macrosyndactyly in his hand. the patient was surgically treated. however, he admitted with lymphangiomas on his body during the follow-up period, leading to the diagnosis of proteus syndrome. this article discusses the differential diagnosis of proteus syndrome and the treatment methods used for macrodactyly along with the presentatio ...	2011	21417989
monitoring of multiple drug-resistant pathogens in a selected stretch of bay of bengal, india.	the present work aims at identification of multiple drug-resistant pathogenic bacteria in a selected stretch, namely, puri on the bay of bengal, india. six stations at the coast of puri were selected and samples of water and sediment were collected during the winter of 2008 and 2009 for this study. thirty-eight pathogenic bacteria were isolated and identified from both the water and the sediment of 6 fixed stations (pu-1a, pu-1b, pu-2, pu-3, pu-4, and pu-5). the identified pathogens were escheri ...	2011	21424669
[correlation between histomorphometric changes and the type of aerobic bacteria isolated in chronic suppurative otitis media].	bacterial flora is a very important factor in pathogenesis of chronic suppurative otitis media (csom) and significantly influences the type and intensity of osteolytic process. there are few histomorphometric investigations of middle ear mucosa in chronic otitis. the aim of this study was to identify aerobic bacteria responsible for chronic suppurative otitis media as well as their association with histomorphometric changes of middle ear mucosa.	2011	21425618
urine cultures from indwelling bladder catheters in nursing home patients: a point prevalence study in a swedish county.	abstract objectives. to survey the bacterial flora and antibiotic resistance in urinary strains from patients with indwelling bladder catheters residing in nursing homes within a geographically defined region. material and methods. urine was sampled for culture from 163 catheter patients (126 men and 37 women) during a 2 week period in march 2010. susceptibility testing of the isolated bacteria was compared with all urinary strains (n = 9994) from hospitals and primary healthcare in the same geo ...	2011	21452928
urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review.	introduction: urease is the enzyme that catalyzes the hydrolysis of urea, which is involved in serious infections caused by helicobacter pylori in the gastric tract, as well as proteus and related species in the urinary tract. the necessity to treat such infections has stimulated intensive studies on various groups of urease inhibitors. areas covered: patent literature on urease inhibitors with possible applications in medicine is reviewed in this paper. hydroxamic acids, phosphoramidates, urea ...	2011	21457123
[chronic pyelonephritis and xanthogranulomatous pyelonephritis].		2011	21458176
inhibition of inos reduces the therapeutic effects of ozone in acute necrotizing pancreatitis: an in vivo animal study.	abstract objective. previously, it was shown that ozone and s-methylthiourea (smt) treatments had ameliorative effects on experimental models of acute necrotizing pancreatitis (anp). it is possible that the combination of ozone and smt may be more effective than either therapy. therefore, we investigated the efficacy of combination therapy with ozone and smt in an experimental rat model of anp. material and methods. sprague-dawley rats were divided into five experimental groups. groups were desi ...	2011	21463160
chronic suppurative otitis media in children of luanda, angola.	aim: evaluation of clinical characteristics, bacteriology and hearing in paediatric patients with and without chronic suppurative otitis media (csom) in luanda, angola. methods: interview, clinical examination, ear-discharge culture, open air pure-tone audiometry and brainstem auditory-evoked potentials of 23 outpatients with csom and 23 controls in a paediatric hospital. results: of the csom vs. control children, 35% vs. 26% had running water, 70% vs. 70% electricity, 64% vs. 0% hiv (p < 0.0 ...	2011	21477130
quantifying selective reporting and the proteus phenomenon for multiple datasets with similar bias.	meta-analyses play an important role in synthesizing evidence from diverse studies and datasets that address similar questions. a major obstacle for meta-analyses arises from biases in reporting. in particular, it is speculated that findings which do not achieve formal statistical significance are less likely reported than statistically significant findings. moreover, the patterns of bias can be complex and may also depend on the timing of the research results and their relationship with previou ...	2011	21479240
cold atmospheric plasma: a successful treatment of lesions in hailey-hailey disease.		2011	21482888
bacteriologic and plasmid analysis of etiologic agents of conjunctivitis in lagos, nigeria.	background: conjunctivitis, an inflammation of the conjunctiva, is one of the most common eye problems affecting all age groups in nigeria. a better understanding of its epidemiology and the antibiotic susceptibility of etiologic bacterial agents is crucial for the initiation of preventive and therapeutic measures. this study determined the distribution and patterns of bacterial infections in nigerian patients with conjunctivitis. antibiotic resistance patterns and the plasmid profiles of these ...	2011	21484175
phytochemical screening and antibacterial activities of vernonia ambigua, vernonia blumeoides and vernonia oocephala (asteraceae).	some vernonia species (vernonia ambigua, vernonia blumeoides and vernonia oocephala) used in northern nigerian traditional medicine, were subjected to phytochemical screening using standard procedures. the antibacterial activity using the disc diffusion method as outlined by the nccls was carried out on klebsiella pneumoniae, streptococcus pyogenes, staphylococcus aureus, corynbacterium ulcerans, methicillin resistant staphylococcus aureus (mrsa), salmonella typhi, pseudomonas aeruginosa, shigel ...	2011	21485703
[cmy-2-type plasmid-mediated ampc ß-lactamases emerging in tucumán, argentina].	in the last years, enterobacteriaceae such as klebsiella pneumoniae, proteus mirabilis and escherichia coli, have acquired resistance to third-generation cephalosporins (c3g) because of the presence of plasmid-mediated ampc ß-lactamases. the aim of this work was to detect plasmid ampc enzymes and to investigate the predominant types in our region. between march and july 2009, 733 consecutive isolates of enterobacteriaceae derived from hospitals and outpatient centers were studied. susceptibility ...	2011	21491062
potential use of 68ga-apo-transferrin as a pet imaging agent for detecting staphylococcus aureus infection.	(67)ga citrate has been extensively used to detect infection and inflammation since 1971. however, its clinical utility is compromised due to several limitations. the present project explored whether (68)ga-apo-transferrin ((68)ga-tf), when prepared in vitro, is a useful agent for positron emission tomography (pet) imaging of bacterial infection.	2011	21492788
identifying patients harboring esbl-producing enterobacteriaceae on hospital admission: derivation and validation of a scoring system.	increases in community-acquired infections caused by extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae have important implications for hospital infection control and empirical antibiotic therapy protocols. we developed and validated a tool for identifying patients harboring these organisms at hospital admission. we retrospectively analyzed chart data for 849 adult inpatients. the derivation cohort included 339 patients admitted to a large rome hospital during 2008, with (n=113) o ...	2011	21537020