Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| Why is Helicobacter pylori disappearing? More questions than answers. | 2011 | 22011710 | |
| Relationship between the Extent of DNA Damage and Gastritis in Normal and Helicobacter pylori-Infected Patients. | The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -negative gastritis according to histological diagnosis. We also compared the percentage of cometed cells on the surface of the gastric epithelial cells to the percentage beneath the gastric mucosal c ... | 2011 | 21927660 |
| Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their Antimicrobial Activity. | Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin-6-C-b-D-glucopyranoside (1), 7-methoxyluteolin-6-C-b-D-glucopyranoside (2), 7-methoxyluteolin-8-C-b-D-glucopyranoside (3), 4'-methoxyluteolin-6-C-b-D-glucopyranoside (4), and 6-hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-trihydroxy-3-methoxyxanthone (6), 8-carboxy-methyl-1,3,5,6-tetrahydroxyxanthone (7). Methanolic extract, fractions, and isolated c ... | 2011 | 22179427 |
| helicobacter pylori-negative gastric cancer in south korea: incidence and clinicopathologic characteristics. | it is difficult to determine the exact incidence rate of helicobacter pylori (h. pylori) infection-negative gastric cancer (hpin-gc) because h. pylori detection rates decrease with the progression of gastric atrophy and intestinal metaplasia. the aim of this study was to evaluate the incidence and clinicopathologic characteristics of hpin-gc in south korea. | 2011 | 21923684 |
| Endoscopic versus histological diagnosis of Barrett's esophagus: a cross-sectional survey. | Context : Barrett's esophagus is a common pathological condition in patients with gastro-esophageal reflux disease. Objective : The aim of this study was to compare endoscopic diagnosis versus histological confirmation. Design : Cross-sectional. Setting: Cancer Institute of the Imam Khomeini Hospital. Material and methods : A total of 50 patients with a history of gastro-esophageal reflux were recruited and underwent upper endoscopy at this cross-sectional survey. Four-quadrant biopsy was tak ... | 2011 | 22102072 |
| the role of the renin-angiotensin system in gastric oncogenesis. | the renin-angiotensin system (ras) plays an important role not only in homeostasis but also in carcinogenesis. recent epidemiological studies suggest that hypertensive patients with up-regulated systemic ras functions are at a significantly increased risk for the subsequent development of cancers with poor outcomes, and moreover that ras inhibitors reduce tumor development, progression, and metastasis. notably, helicobacter pylori infection, one of the major predictors of gastric carcinogenesis, ... | 2011 | 22114933 |
| The association between Helicobacter Pylori chronic gastritis, psychological trauma and somatization disorder. A case report. | Helicobacter Pylori is considered to be the agent responsible for peptic ulcers and gastritis, and its eradication represents a main objective in the treatment of digestive diseases. We present the case report of a female patient diagnosed with chronic Helicobacter Pylori infection, where symptoms manifested after the patient was raped. In the context of psychological trauma, digestive manifestations such as ulcer and gastritis were identified, greatly exacerbated as compared with the endoscopic ... | 2011 | 21961102 |
| Detection of Helicobacter pylori DNA in a preliminary stage gastric cancer cells. | AIMS:: Helicobacter pylori (HP) DNA was assayed using a newly fabricated voltammetric handheld circuit equipped with an interfaced graphite pencil electrode (PE) sensor. METHODS:: Under optimum analytical parameters, the square-wave (SW) stripping detection range attained was 0.1-0.7?mg/L. RESULTS:: A relative standard deviation of 1.68% (RSD, n?=?5) was observed at a 3.2?mg/L HP DNA within a 90?s accumulation time. Under these conditions, the analytical detection limit approached 0.07?mg/L. CON ... | 2011 | 22186672 |
| Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. | A strong cellular cross-talk exists between the pathogen Helicobacter pylori and high-output NO production. However, how NO and H. pylori interact to signal in gastric epithelial cells and modulate the innate immune response is unknown. We show that chemical or cellular sources of NO induce the anti-inflammatory effector heme oxygenase-1 (HO-1) in gastric epithelial cells through a pathway that requires NF-?B. However, H. pylori decreases NO-induced NF-?B activation, thereby inhibiting HO-1 expr ... | 2011 | 21987660 |
| Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1. | Helicobacter pylori induces an infiltration of dendritic cells (DCs) into the infected gastric mucosa. Although DCs play an important role in the regulation of inflammation, the effects of H. pylori vacuolating cytotoxin (VacA) on DC maturation process have not yet been elucidated. The role of VacA in DC maturation following co-exposure to Escherichia coli lipopolysaccharide (LPS) was investigated. The treatment of immature DCs with LPS up-regulated the expression of surface molecules [e.g. CD40 ... | 2011 | 21910723 |
| Helicobacter pylori: beneficial for most? | 2011 | 22017690 | |
| [Genotyping and molecular marking of bacteria and viruses in epidemiological surveillance of actual infections]. | Determination of genetic and molecular features of pathogens circulating in Russia, in the northwest of the country and in St. Petersburg to resolve the problems of spread of diseases caused by these pathogens. | 2011 | 21913388 |
| Oral immunization with recombinant Mycobacterium smegmatis expressing the outer membrane protein 26-kilodalton antigen confers prophylactic protection against Helicobacter pylori infection. | Helicobacter pylori infection is prevalent worldwide and results in chronic gastritis, which may lead to gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer. We have previously reported that oral immunization with recombinant Mycobacterium smegmatis expressing the H. pylori outer membrane protein 26-kilodalton (Omp26) antigen affords therapeutic protection against H. pylori infection in mice. In the present study, we investigated the prophylactic effects of this vaccine candida ... | 2011 | 21900527 |
| antimicrobial activity of an amazon medicinal plant (chancapiedra) (phyllanthus niruri l.) against helicobacter pylori and lactic acid bacteria. | the potential of water extracts of the amazon medicinal plant chancapiedra (phyllanthus niruri l.) from ecuador and peru for antimicrobial activity against helicobacter pylori and different strains of lactic acid bacteria such as lactobacillus acidophilus, lactobacillus casei and lactobacillus plantarum was investigated. h. pylori was inhibited by both water extracts in a dose dependent manner, whereas lactic acid bacterial growth was not affected. both extracts contained ellagic acid and hydrox ... | 2011 | 22034238 |
| Ten-day sequential therapy is more effective than proton-pump inhibitor-based therapy in Korea: a prospective randomized study. | Background and Aims: The eradication rate of proton-pump inhibitor (PPI)-based triple therapy for Helicobacter pylori (H. pylori) infection has decreased mainly due to increasing antibiotic resistance, especially against clarithromycin. It has been reported that a 10-day sequential strategy can produce good outcomes. The aim of this prospective study was to assess the efficacy of sequential therapy as the first-line treatment for eradication of H. pylori in Korea. Materials and Methods: A total ... | 2011 | 21916989 |
| Immunosuppressive proteins isolated from spiral and coccoid cytoplasmic solutions of Helicobacter pylori. | The aim of this study was to investigate the antiproliferative proteins that probably have a role in Helicobacter pylori evade of immune response and cause chronic infection disease and also to see if coccoid form had a role in its chronicity. H. pylori strain VacA s2/m2 positive and CagA negative, from a gastric biopsy of a patient with peptic ulcer disease, was isolated and cultured in brucella agar. Both spiral and coccoid forms were harvested and ruptured by sonication. The cytoplasmic solut ... | 2011 | 21916264 |
| Correlation between creatinine clearance and Helicobacter pylori infection eradication with sequential and triple therapeutic regimens: A randomised clinical trial. | Uraemic patients show susceptibility to gastrointestinal mucosal lesions and colonisation by Helicobacter pylori (HP). Antibiotic resistance constitutes a problem in treatment and bismuth preparations are toxic in uraemic patients. This study aimed to assess the correlation between creatinine clearance (CrCl) and eradication of HP infection with new sequential and standard triple therapeutic regimens. | 2011 | 22055594 |
| Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians. | Several polymorphisms of genes involved in the immunological recognition of Helicobacter pylori and regulating apoptosis and proliferation have been linked to gastric carcinogenesis, however reported data are partially conflicting. The aim of our study was to evaluate potential associations between the presence of gastric cancer (GC) and high risk atrophic gastritis (HRAG) and polymorphisms of genes encoding Angiotensin converting enzyme (ACE), Nod-like receptor 1 (NOD1), Toll-like receptor 4 (T ... | 2011 | 21864388 |
| Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. | The increasing therapeutic failures against Helicobacter pylori infection has determined the need to develop new drugs. The susceptibility to resveratrol (1) of twenty-six H. pylori strains representing nine CagA+ strains from patients with gastric carcinoma and eight CagA- and nine CagA+ strains from patients with chronic gastritis only was evaluated. Compound 1 was dissolved in DMSO and double diluted in Brucella broth with 10% BFS; ca. 10(6) organisms were added to each dilution. After incuba ... | 2011 | 21936484 |
| Tumor biomarker glycoproteins in the seminal plasma of healthy human males are endogenous ligands for DC-SIGN. | DC-SIGN is an immune C-type lectin that is expressed on both immature and mature dendritic cells associated with peripheral and lymphoid tissues in humans. It is a pattern recognition receptor that binds to several pathogens including HIV-1, Ebola virus, Mycobacterium tuberculosis, Candida albicans, Helicobacter pylori, and Schistosoma mansoni. Evidence is now mounting that DC-SIGN also recognizes endogenous glycoproteins, and that such interactions play a major role in maintaining immune homeo ... | 2011 | 21986992 |
| Heme iron from meat and risk of adenocarcinoma of the esophagus and stomach. | Iron can cause oxidative stress and DNA damage, and heme iron can catalyze endogenous formation of N-nitroso compounds, which are potent carcinogens. Dietary iron promotes esophageal cancer incidence in animal studies and has been identified as a growth factor for Helicobacter pylori, an established risk factor for stomach cancer. We conducted a population-based case-control study of adenocarcinoma of the esophagus (n=124) and stomach (n=154) and 449 controls in Nebraska. Heme iron and total iro ... | 2011 | 22044848 |
| Gastrectomy with isoperistaltic jejunal parallel pouch in a 15-year-old adolescent boy with gastric adenocarcinoma and autosomal recessive agammaglobulinemia. | A 15-year-old adolescent boy with autosomal recessive agammaglobulinemia underwent endoscopy because of unexplained growth failure and malnutrition. Esophagogastroduodenoscopy revealed antropyloric stenosis, and a biopsy showed an invasive gastric adenocarcinoma. Chronic atrophic corpus gastritis type A and Helicobacter pylori were also identified. Abdominal magnetic resonance imaging confirmed the stenosis resulting from a semicircular intramural tumor without obvious local or distant metastati ... | 2011 | 21929971 |
| Long-Term Followup of Patients with Active J-Reservoirs after Restorative Proctocolectomy for Ulcerative Colitis with regard to Reservoir Function, Mucosal Changes, and Quality of Life. | Objective. Study the functional results and mucosal changes in the ileal pouch after restorative proctocolectomy with J-reservoir for ulcerative colitis. Material and Methods. Followup study of 125 patients with J-reservoir with one disease-specific- and one general (SF-36) quality of life-questionnaire, rectoscopy with biopsies, and stool samples to evaluate inflammation, dysplasia, presence of Helicobacter pylori and calprotectin level. Results. Fourteen J-reservoirs were removed or deactivate ... | 2011 | 21991508 |
| Effectiveness and safety of repeated quadruple therapy in Helicobacter pylori infection after failure of second-line quadruple therapy: repeated quadruple therapy as a third-line therapy. | Quadruple therapy using a proton-pump inhibitor, bismuth, metronidazole, and tetracycline is a standard second-line therapy for Helicobacter pylori infection, achieving an eradication rate of about 80% in Korea. A standard third-line therapy is not currently established, although various protocols have been proposed. We performed this study to evaluate the effectiveness of a retrial with quadruple therapy before starting a third-line treatment with new drugs. | 2011 | 21923688 |
| Endothelial dysfunction is reversible in Helicobacter pylori-positive subjects. | Studies have shown an association between Helicobacter pylori (HP) infection and atherosclerosis. Although epidemiological studies have suggested an association between HP infection and atherosclerosis, the issue is still controversial. It is not clear whether HP eradication will reverse endothelial damage and prevent cardiovascular events. | 2011 | 22114831 |
| Low prevalence of Helicobacter pylori-negative gastric cancer among Japanese. | The true prevalence of Helicobacter pylori-negative gastric cancer (HpNGC) is unknown. We attempt to clarify the prevalence and clinicopathologic features of HpNGC in Japanese. | 2011 | 22059391 |
| Inhibition of caspase-8 activity caused by overexpression of bcl10 contributes to the pathogenesis of high-grade MALT lymphoma. | BACKGROUND: Mucosa-associated lymphoid tissue (MALT) lymphoma comprises approximately 8% of all non-Hodgkin lymphomas and is the most common lymphoma in the gastro-intestinal tract. It is caused by genetic abnormalities or bacterial infections/chronic inflammation. B-cell lymphoma/leukemia 10 (BCL10) overexpression and nuclear expression have been associated with high-grade MALT lymphomas with genetic abnormalities that are unresponsive to Helicobacter pylori eradication treatment. To explore th ... | 2011 | 21954216 |
| gastric cancer in africa: what do we know about incidence and risk factors? | gastric cancer is a major contributor to mortality worldwide, yet its incidence varies widely around the world in a way which our current understanding of aetiology cannot fully explain. incidence data from africa are weak, reflecting poor diagnostic resources, but there are firm data on intestinal metaplasia and gastric atrophy which are important steps in the carcinogenesis pathway. the available registry data suggest that incidence is unlikely to be dramatically different from europe or north ... | 2011 | 22136952 |
| quality of rcts exploring helicobacter pylori eradication for the prevention of gastric cancer and preneoplastic lesions. | randomized controlled trials (rcts) are considered the gold standard for evaluating the efficacy of clinical interventions and developing evidence-based clinical practice guidelines; however, they can yield biased results when their methodology is less than rigorous, or their published reports fail to report key items. a number of rcts have been carried out to explore the relationship between helicobacter pylori eradication and gastric cancer, but their results remain controversial. in this arti ... | 2011 | 21999125 |
| Association between Helicobacter pylori Seropositivity and the Coronary Artery Calcium Score in a Screening Population. | Helicobacter pylori causes numerous extragastric manifestations, including coronary heart disease. The coronary artery calcification (CAC) score, measured using computed tomography (CT) has been used as a screening test for coronary atherosclerosis. This study investigated the association between H. pylori seropositivity and CAC scores in a screening population. | 2011 | 21927661 |
| upper gastrointestinal bleedings in patients with hereditary coagulation disorders in northwest of iran: prevalence of helicobacter pylori infection. | upper gastrointestinal (ugi) bleeding is one of the most life-threatening complications, in up to 25% of persons with hemophilia (pwh). recurrent bleeding is common and can be caused by the helicobacter pylori infection. our aim was to evaluate the role of h. pylori infection in ugi bleeding in pwh. | 2011 | 21904206 |
| helicobacter pylori antibiotic resistance in brazil: clarithromycin is still a good option. | the antibiotic susceptibility is the cornerstone for the eradication therapies of helicobacter pylori. | 2011 | 22147131 |
| Gastric and duodenum microflora analysis after long-term Helicobacter pylori infection in Mongolian Gerbils. | Long-term Helicobacter pylori infection leads to chronic gastritis, peptic ulcer, and gastric malignancies. Indigenous microflora in alimentary tract maintains a colonization barrier against pathogenic microorganisms. This study is aimed to observe the gastric and duodenum microflora alteration after H. pylori infection in Mongolian Gerbils model. | 2011 | 21923685 |
| gastrointestinal immune system and brain dialogue implicated in neuroinflammatory and neurodegenerative diseases. | a common characteristic of the central nervous system (cns) neurodegenerative disorders is neuroinflammation, marked by augmented numbers of activated and primed microglia, increased inflammatory cytokines and decreased anti-inflammatory molecules. cns neuroinflammation is a critical component in the progression of several neurodegenerative diseases which sensitize the brain to produce an exaggerated response to immune stimuli in the periphery. neuroinflammation might initiate from the periphery ... | 2011 | 21902649 |
| induction of cd69 expression by cagpai-positive helicobacter pylori infection. | to investigate and elucidate the molecular mechanism that regulates inducible expression of cd69 by helicobacter pylori (h. pylori) infection. | 2011 | 21990950 |
| Male Gender, Hiatus Hernia and Helicobacter Pylori Infection Associated with Asymptomatic Erosive Esophagitis. | Background and Aims: Asymptomatic erosive esophagitis (AEE) is an easily forgotten subgroup of gastroesophageal reflux disease (GERD) due to it's lack of warning symptoms despite having the risk of developing complications such as bleeding, stricture or even esophageal adenocarcinoma. Materials and Methods: A total of 2843 potentially eligible subjects were screened at the health management center of Buddhist Tzu Chi General Hospital. 1002 subjects responded to this survey and gave informed cons ... | 2011 | 21871022 |
| complete genome sequence of "candidatus tremblaya princeps" strain pcval, an intriguing translational machine below the living-cell status. | the sequence of the genome of "candidatus tremblaya princeps" strain pcval, the primary endosymbiont of the citrus mealybug planococcus citri, has been determined. "ca. tremblaya princeps" presents an unusual nested endosymbiosis and harbors a gammaproteobacterial symbiont within its cytoplasm in all analyzed mealybugs. the genome sequence reveals that "ca. tremblaya princeps" cannot be considered an independent organism but that the consortium with its gammaproteobacterial symbiotic associate r ... | 2011 | 21914892 |
| expansion of european vaca and caga alleles to east-asian helicobacter pylori strains in cambodia. | helicobacter pylori infection is associated with gastric cancer (gc). the highest incidence rates have been described in asia, but regional variations exist that do not match the distribution of infection prevalence rates. the aim of the study was to examine the possible contribution of h. pylori virulence factors to geographic differences in the incidence of gc across east and southeast asia. we studied 66 isolates from cambodian patients that had previously been assigned to two genetic populat ... | 2011 | 21871583 |
| effect of endoscopic screening at 1-year intervals on the clinicopathologic characteristics and treatment of gastric cancer in south korea. | background and aim: the recommended interval of endoscopic screening for gastric cancer (gc) in a general population is 2 years in korea. however, it has not been determined whether endoscopic screening with a shorter interval is beneficial, especially for high-risk groups. methods: a total of 415 patients with gc were categorized according to whether they had (vigilant screening group) or not (non-vigilant screening group) undergone endoscopic screening within 1 year before being diagnosed with ... | 2011 | 22142434 |
| New urea biosensor based on urease enzyme obtained from Helycobacter pylori. | The urease enzyme of Helicobacter pylori was isolated from biopsy sample obtained from antrum big curvature cell extracts. A new urea biosensor was prepared by immobilizing urease enzyme isolated from Helicobacter pylori on poly(vinylchloride) (PVC) ammonium membrane electrode by using nonactine as an ammonium ionophore. The effect of pH, buffer concentration, and temperature for the biosensor prepared with urease from H. pylori were obtained as 6.0, 5 mM, and 25 °C, respectively. We also invest ... | 2011 | 21881954 |
| Helicobacter pylori and nonmalignant diseases. | Research published over the past year has documented the continued decline of Helicobacter pylori-related peptic ulcer disease and increased recognition of non-H. pylori, non-steroidal anti-inflammatory drugs ulcer disease--idiopathic ulcers. Despite reduced prevalence of uncomplicated PUD, rates of ulcer complications and associated mortality remain stubbornly high. The role of H. pylori in functional dyspepsia is unclear, with some authors considering H. pylori-associated nonulcer dyspepsia a ... | 2011 | 21896083 |
| A new look at anti-Helicobacter pylori therapy. | With the rising prevalence of antimicrobial resistance, the treatment success of standard triple therapy has recently declined to unacceptable levels (i.e., 80% or less) in most countries. Therefore, several treatment regimens have emerged to cure Helicobacter pylori (H. pylori) infection. Novel first-line anti-H. pylori therapies in 2011 include sequential therapy, concomitant quadruple therapy, hybrid (dual-concomitant) therapy and bismuth-containing quadruple therapy. After the failure of sta ... | 2011 | 22046084 |
| modulation of the cd4+ t-cell response by helicobacter pylori depends on known virulence factors and bacterial cholesterol and cholesterol α-glucoside content. | helicobacter pylori blocks the proliferation of human cd4(+) t cells, facilitated by vacuolating exotoxin (vaca) and γ-glutamyl transpeptidase (ggt). h. pylori-triggered t-cell reactions in mice correlate with bacterial cholesterol and cholesterol α-glucoside content but their role in human cells is unclear. we characterized the effect of vaca, ggt, and cholesterol on t-helper 1, t-helper 2, t-regulatory and t-helper 17 associated cytokines and t-cell proliferation. vaca, ggt, and bacterial chol ... | 2011 | 21921201 |
| Multiple Gastric Carcinomas Associated with Potter Type III Cystic Disease. | We report a case of multiple gastric carcinomas associated with Potter type III cystic disease of the liver, mesenterium and kidney. A 65-year-old man with chronic renal failure due to polycystic kidneys and under hemodialysis treatment 3 times a week for 2 years was admitted to our hospital because of anemia. He stated that his sister had suffered from polycystic kidney disease. Gastrointestinal fiberscopy showed two lesions in the lesser curvature in the lower portion of the stomach, and histo ... | 2011 | 22110420 |
| Barrett's Esophagus in an Area with an Exceptionally Low Prevalence of Helicobacter pylori Infection. | Objective. This study was undertaken to gain an insight into the relationship between Helicobacter pylori (H. pylori) infection, Barrett's esophagus and reflux esophagitis in an area of exceptionally low prevalence of H. pylori infection. Methods. A total of 1895 consecutive upper endoscopies performed between January 2005 and July 2007 were reviewed. 120 cases of columnar-lined esophagus and endoscopic esophagitis were evaluated. H. pylori infection was determined using the urease test and/or h ... | 2011 | 21991505 |
| ectopic expression of guanylyl cyclase c and endogenous ligand guanylin correlates significantly with helicobacter pylori infection in gastric carcinogenesis. | the molecular mechanisms leading to gastric carcinogenesis still remain unclear. recently, several studies demonstrated that over-expression of guanylyl cyclase c (gcc) has been detected in intestinal-type gastric cancer (gc) and precursor lesions. our objective was to explore the expression levels of gcc and endogenous ligands guanylin (gn) and uroguanylin (ugn) and the correlation between helicobacter pylori (h. pylori) and gcc, gn, and ugn expressions in patients at different stages from norm ... | 2011 | 21972003 |
| barrett's esophagus: prevalence-incidence and etiology-origins. | although the prevalence of barrett's esophagus (be) is rising no data exist for racial minorities on prevalence in the general population. minorities have a lower prevalence than caucasians, and yet age, smoking, abdominal obesity, and helicobacter pylori are all risk factors. metabolic changes induced by adipocytokines and the apparently strong association between obesity, central adiposity, and be may lead to reconsideration of some aspects of the natural history of be. there is lack of experi ... | 2011 | 21950804 |
| inflammation, immunity, and vaccine development for helicobacter pylori. | the immune response to helicobacter pylori entails both innate effectors and a complex mix of th1, th17, and treg adaptive immune responses. the clinical outcome of infection may well depend to a large degree on the relative balance of these responses. vaccination with a wide range of antigens, adjuvants, and delivery routes can produce statistically significant reductions in h. pylori colonization levels in mice, though rarely sterilizing immunity. whether similar reductions in bacterial load c ... | 2011 | 21896082 |
| detection of helicobacter pylori in raw bovine milk by fluorescence in situ hybridization (fish). | the transmission pathways of helicobacter pylori in humans have not been fully elucidated. research in the last decade has proposed that foodborne transmission, among others, may be a plausible route of human infection. owing to the organism's fastidious growth characteristics and its ability to convert to viable, yet unculturable states upon exposure to stress conditions, the detection of h. pylori in foods via culture-dependent methods has been proven to be laborious, difficult and in most cas ... | 2011 | 21974980 |
| prevalence and incidence of helicobacter pylori infection in a healthy pediatric population in the lisbon area. | helicobacter pylori is mainly acquired in childhood. although adult studies reported a high prevalence of h. pylori infection in portugal, the actual rate in children remains unknown. this study aimed to determine the prevalence and the incidence of h. pylori infection in an asymptomatic pediatric population of the lisbon area and to correlate prevalence with sociodemographic determinants. | 2011 | 21923682 |
| Selective detection of viable Helicobacter pylori using ethidium monoazide or propidium monoazide in combination with real-time polymerase chain reaction. | Because Helicobacter pylori has a role in the pathogenesis of gastric cancer, chronic gastritis and peptic ulcer disease, detection of its viable form is very important. The objective of this study was to optimize a PCR method using ethidium monoazide (EMA) or propidium monoazide (PMA) for selective detection of viable H. pylori cells in mixed samples of viable and dead bacteria. Before conducting the real-time PCR using SodB primers of H. pylori, EMA or PMA was added to suspensions of viable an ... | 2011 | 22004535 |
| high prevalence of dna from non-h. pylori helicobacters in the gastric mucosa of venezuelan pet dogs and its histological alterations. | non-h. pylori helicobacters (nhph) have been demonstrated as gastric spiral-shaped bacteria in specimens obtained from dogs; however, their roles in the pathogenesis of upper gastrointestinal disease have not yet been clearly established. the purpose of this study was to evaluate the prevalence of nhph dna in the gastric mucosa of dogs and its association with histopathology. helicobacter was detected through histopathological techniques, pcr, and fish analysis from fundic biopsies of twenty dog ... | 2011 | 21915464 |
| Oral administration of chios mastic gum or extracts in mice: quantification of triterpenic acids by liquid chromatography-tandem mass spectrometry. | Chios mastic gum, the resin obtained as an exudate from the trunk and branches of Pistacia lentiscus L var. chia, is used extensively as a constituent of herbal drugs or functional foods. The oral absorption of its major constituents still remains unclear. In the context of identifying the features of mastic gum that are responsible for either therapeutic effects or effects of nutritional value, a methodology based on high-performance liquid chromatography (HPLC) coupled to tandem mass spectrome ... | 2011 | 21870323 |
| Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal. | Helicobacter pylori (H. pylori) antibiotic resistance is the main factor affecting the efficacy of the current eradicating therapies. The aim of this editorial is to report on the recent information about the mechanisms accounting for the resistance to the different antibiotics currently utilized in H. pylori eradicating treatments. Different mechanisms of resistance to clarithromycin, metronidazole, quinolones, amoxicillin and tetracycline are accurately detailed (point mutations, redox intrace ... | 2011 | 21860834 |
| polyclonal antibody against conserved sequences of mce1a protein blocks mtb infection in macrophages. | the pathogenesis of mycobacterium tuberculosis is largely due to its ability to enter and survive within human macrophages. it is suggested that a specific protein namely mammalian cell entry protein is involved in the pathogenesis and the specific gene for this protein mce1a has been identified in several pathogenic organisms such as rickettsia, shigella, escherichia coli, helicobacter, streptomyces, klebsiella, vibrio, neisseria, rhodococcus, nocardioides, saccharopolyspora erthyrae, and pseud ... | 2011 | 22159737 |
| screening of antimicrobial activity of cistus ladanifer and arbutus unedo extracts. | in this work, the in vitro antimicrobial activity of different crude extracts obtained from cistus ladanifer l. and arbutus unedo l. was investigated. the ethanol, methanol and acetone/water extracts of cistus ladanifer and arbutus unedo were prepared using different extraction methods and their antimicrobial activities against reference strains, including three gram-positive, five gram-negative and three yeasts, and against clinical isolates of helicobacter pylori and methicillin-resistant stap ... | 2011 | 22077559 |
| [The correlation between oral colonization of Helicobacter pylori and gastrointestinal disease]. | To investigate the correlation between Helicobacter pylori (H. pylori) colonization in the oral cavity and gastrointestinal disease. | 2011 | 21932650 |
| Presence of Minimal Change Esophagitis Closely Correlates with Pathological Conditions in the Stomach. | INTRODUCTION: It is suggested that minimal change (grade M) esophagitis is a spectrum of gastric acid reflux disease. We evaluated the clinical significance of grade M esophagitis, including its subtypes (reddish change: MR and whitish change: MW), especially with attempt to pathological conditions in the stomach that relates to gastric acid secretion. MATERIALS AND METHODS: Using 241 subjects undergoing esophago ... | 2011 | 22089252 |
| Helicobacter pylori eradication in functional dyspepsia: HEROES trial. | Eradication of Helicobacter pylori in patients with functional dyspepsia continues to be a matter of debate. We studied eradication effects on symptoms and quality of life of primary care patients. | 2011 | 22123802 |
| Influence of organic and functional dyspepsia on work productivity: the HEROES-DIP study. | Dyspepsia is defined as persistent or recurrent abdominal pain or discomfort centered in the upper abdomen. Dyspepsia represents up to 8.3% of all primary care physician visits and causes huge economic costs to patients and to the economy as a whole. The aim of this study was to measure the influence of dyspepsia on work productivity of people within the Brazilian workforce. | 2011 | 21839884 |
| [Primary antibiotic resistance of Helicobacter pylori strains and eradication rate according to gastroduodenal disease in Korea]. | This study was performed to evaluate whether the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates and the eradication rate of H. pylori could be different between cancer and non-cancer patients. | 2011 | 21873821 |
| Anemia and Helicobacter pylori seroreactivity in a rural Haitian population. | Anemia is a significant health concern worldwide and can be the result of nutritional, environmental, social, and infectious etiologies. We estimated the prevalence of anemia in 336 pre-school children and 132 adults in the rural Central Plateau of Haiti and assessed associations with age, sex, household size, water source, sanitation, and Helicobacter pylori seroreactivity using logistic regression analysis; 80.1% (269/336) of children and 63.6% (84/132) of adults were anemic. Among children, y ... | 2011 | 22049049 |
| world gastroenterology organisation global guideline: helicobacter pylori in developing countries. | 2011 | 21955424 | |
| diabetes mellitus and gastric carcinoma: is there an association? | diabetes mellitus (dm) has been associated with the risk of several gastrointestinal cancers including liver, pancreas, colon and rectum. however, the evidence is inconclusive for gastric adenocarcinoma (gc). in the current review, we summarize 20 population-based cohort studies that compared gc incidence and mortality between diabetic and non-diabetic population. we discuss the shared risk factors and provide qualitative and quantitative (meta-analytic) summary of the current evidence evaluatin ... | 2011 | 22190872 |
| [morpho-functional peculiarities of autoimmune gastritis in different age groups]. | in 98 patients with chronic gastritis clinical-morphologic analysis was performed. the analysis included: the examination of gastric biopsy specimens, determination of hp-status by means of a group of methods, determination of antibodies to h+/k+ -atpase of parietal cells of the gastric wall, igg-ea-ebv and igm-na-ebn antibodies in the blood serum by means of ifa method, pepsinogene i, pepsinogene ii, gastrin and antibodies to hp with the use of biohit gastric panel, 24-hour monitoring of intrag ... | 2011 | 21916231 |
| antibacterial effects of the urushiol component in the sap of the lacquer tree (rhus verniciflua stokes) on helicobacter pylori. | urushiol is a major component of the lacquer tree which has been used as a folk remedy for the relief of abdominal discomfort in korea. the aim of this study was to evaluate the antibacterial effects of the urushiol on helicobacter pylori. | 2011 | 22059394 |
| [Staging gastritis with the OLGA system: Prevalence of advanced stages of gastric atrophy in Mexican patients]. | Introduction: Gastric adenocarcinoma of intestinal type is preceded by inflammation, which produces mucosal atrophy and intestinal metaplasia, progressing eventually to dysplasia and invasive cancer. Recently an international group, the Operative Link on Gastritis Assessment (OLGA) proponed a staging system for gastric biopsies. Objective: To recognize the distribution of advanced stages of gastric mucosal atrophy in Mexican patients with dyspepsia according to the OLGA system. Methods: We apply ... | 2011 | 22188954 |
| H. pylori vaccines: Why we still don't have any. | Helicobacter pylori was appreciated as the major cause of peptic ulcers about 30 years ago and the most significant etiological agent in gastric cancer in the mid-1990s. Since that time, progress in the development of a preventive or therapeutic H. pylori vaccine has been relatively slow. The impediments to rapid advances in the field include a luke-warm enthusiasm among clinicians, research scientists, and public health authorities concerning the need for a vaccine, rudimentary understanding of ... | 2011 | 22048119 |
| regulation of the actin cytoskeleton in helicobacter pylori-induced migration and invasive growth of gastric epithelial cells. | abstract: dynamic rearrangement of the actin cytoskeleton is a significant hallmark of helicobacter pylori (h. pylori) infected gastric epithelial cells leading to cell migration and invasive growth. considering the cellular mechanisms, the type iv secretion system (t4ss) and the effector protein cytotoxin-associated gene a (caga) of h. pylori are well-studied initiators of distinct signal transduction pathways in host cells targeting kinases, adaptor proteins, gtpases, actin binding and other p ... | 2011 | 22044652 |
| Gastric cancer: clinical aspects, epidemiology and molecular background. | The validity and usefulness of the 7th edition of the UICC tumor node metastasis classification in the context of clinical management of gastric cancer are discussed. The most relevant new agent in gastric cancer therapy is trastuzumab for HER2-positive gastric carcinomas. This marks the success of continuous effort of translational research. Trastuzumab, initially applied in palliative settings, is currently being evaluated also in neoadjuvant treatment regimens. Several new meta-analyses suppo ... | 2011 | 21896085 |
| Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation: Effect of Ghrelin. | Gastric mucosal inflammatory response to H. pylori and its key virulence factor, lipopolysaccharide (LPS), are characterized by a massive rise in apoptosis and the disturbances in NO signaling pathways. Here, we report that H. pylori LPS-induced enhancement in the mucosal inducible nitric oxide synthase (iNOS) was associated with the suppression in Akt kinase activity and the impairment in constitutive nitric oxide synthase (cNOS) phosphorylation. Further, we demonstrate that the LPS effect on A ... | 2011 | 21991502 |
| motility and chemotaxis in campylobacter and helicobacter . | flagellar motility of campylobacter jejuni and helicobacter pylori influences host colonization by promoting migration through viscous milieus such as gastrointestinal mucus. this review explores mechanisms c. jejuni and h. pylori employ to control flagellar biosynthesis and chemotactic responses. these microbes tightly control the activities of σ(54) and σ(28) to mediate ordered flagellar gene expression. in addition to phase-variable and posttranslational mechanisms, flagellar biosynthesis is ... | 2011 | 21939377 |
| Cranberry components for the therapy of infectious disease. | Summary of the in vitro data support a beneficial effect of cranberry or its proanthocyanin constituents by blocking adhesion to and biofilm formation on target tissues of pathogens. In vivo data partially support these beneficial effects. Consumption of various cranberry products benefited young and elderly females in preventing urinary tract infections, and in conjunction with antibiotic treatment in eradicating Helicobacter pylori infections in women. Mouthwash supplemented with an isolated c ... | 2011 | 22088310 |
| prevalence of pediatric helicobacter pylori infection in taiwan. | 2011 | 22118323 | |
| introduction of an examination and treatment for helicobacter pylori infection in high school health screening. | recently, a significant relationship between gastric cancer and helicobacter pylori infection has been proven. the purpose of this study was to elucidate the actual conditions of h. pylori infection in japanese teenagers. | 2011 | 21853260 |
| peripheral lymphocyte dna damage and oxidative status after eradication therapy in patients infected with helicobacter pylori. | helicobacter pylori infection has been shown to cause inflammation, increased production of reactive oxygen species, and oxidative dna damage in the gastric mucosa. however, the effect of eradication treatment on dna damage in patients infected with h. pylori is unclear. | 2011 | 22012003 |
| Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? | The aetiology of tympanosclerosis is not yet clear. This prospective, controlled, clinical study investigated the relationship between Helicobacter pylori and tympanosclerosis aetiology. | 2011 | 21888743 |
| helicobacter pylori exploits a unique repertoire of type iv secretion system components for pilus assembly at the bacteria-host cell interface. | colonization of the human stomach by helicobacter pylori is an important risk factor for development of gastric cancer. the h. pylori cag pathogenicity island (cag pai) encodes components of a type iv secretion system (t4ss) that translocates the bacterial oncoprotein caga into gastric epithelial cells, and cagl is a specialized component of the cag t4ss that binds the host receptor α5β1 integrin. here, we utilized a mass spectrometry-based approach to reveal co-purification of cagl, cagi (anoth ... | 2011 | 21909278 |
| Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. | L: -arginine (L: -Arg) is metabolized by nitric oxide synthase and arginase enzymes. The gastric pathogen Helicobacter pylori causes peptic ulcer disease and gastric cancer. We have shown that alterations in L: -Arg availability and metabolism into polyamines contribute significantly to the dysregulation of the host immune response to this infection. Nitric oxide (NO) derived from inducible NO synthase (iNOS) can kill H. pylori. There are multiple mechanisms leading to failure of this process, i ... | 2011 | 21874531 |
| H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. | MicroRNAs have been implicated as a central regulator of the immune system. We have previously reported that Helicobacter pylori (H. pylori) was able to increase the expression of miR-146a, and miR-146a may negatively regulate H. pylori-induced inflammation, but the exact mechanism of how H. pylori contribute the induction of miR-146a is not clear. Here, we attempted to assess the role of H. pylori related proinflammatory cytokines including interleukin (IL)-8, tumor necrosis factor (TNF)-a, and ... | 2011 | 21947847 |
| The crystal structure of ADP-L-glycero-D-manno-heptose-6-epimerase (HP0859) from Helicobacter pylori. | Helicobacter pylori, the human pathogen that affects about half of the world population and that is responsible for gastritis, gastric ulcer and adenocarcinoma and MALT lymphoma, owes much of the integrity of its outer membrane on lipopolysaccharides (LPSs). Together with their essential structural role, LPSs contribute to the bacterial adherence properties, as well as they are well characterized for the capability to modulate the immuno-response. In H. pylori the core oligosaccharide, one of th ... | 2011 | 21979583 |
| Helicobacter species in the atherosclerotic plaques of patients with coronary artery disease. | INTRODUCTION: Several epidemiological studies have proposed an association between Helicobacter pylori infection and coronary artery disease. In the current study, we aimed to evaluate the prevalence and relevance of H. pylori infection, using polymerase chain reaction (PCR) methods, in the coronary arterial wall of Iranian patients who have already undergone coronary bypass grafting (CABG). METHODS: A total of 105 consecutive patients who underwent CABG at the Department of Cardiovascular Surge ... | 2011 | 22104005 |
| association between oral health and gastric precancerous lesions. | although recent studies have suggested that tooth loss is positively related to the risk of gastric non-cardia cancer, the underlying oral health conditions potentially responsible for the association remain unknown. we investigated whether clinical and behavioral measures of oral health are associated with the risk of gastric precancerous lesions. we conducted a cross-sectional study of 131 patients undergoing upper gastrointestinal endoscopy. cases were defined as those with gastric precancero ... | 2011 | 22139442 |
| the role of interleukin 10 in the prevention of allergic asthma in mouse models with helicobacter pylori infection. | 2011 | 21997957 | |
| inactivation of cox-2, hmlh1 and cdkn2a gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and helicobacter pylori genotype. | we aimed to evaluate the inactivation of cox-2, hmlh1 and cdkn2a by promoter methylation and its relationship with the infection by different helicobacter pylori strains in gastric cancer. | 2011 | 21849808 |
| helicobacter pylori resistance to rifabutin in the last 7 years. | a low rate of resistance (0.24%) to rifabutin was noted in helicobacter pylori strains isolated from 414 japanese patients. the only rifabutin-resistant strain detected showed a point mutation in the rpob gene and was isolated from a patient with a history of rifampin treatment for pulmonary tuberculosis. | 2011 | 21896915 |
| extragastric manifestations of helicobacter pylori infection. | in the previous year, some extragastric diseases, possibly linked to helicobacter pylori infection, have been largely investigated. there are, in fact, several studies concerning cardiovascular diseases, lung diseases, hematologic diseases, eye and skin diseases, hepatobiliary diseases, diabetes mellitus, and neurological disorders. among them, the relationship between bacterial caga positivity and coronary heart disease is reportedly emphasized. concerning normal tension glaucoma, new interesti ... | 2011 | 21896088 |
| [comparative analysis between breath test, serological immunoassay and rapid-urease test for detection of helicobacter pylori infection in mexican patients with non-investigated dyspepsia]. | introduction: there are multiple helicobacter pylori (hp) detection tests, some are invasive and other noninvasive. the diagnostic accuracy of these methods varies according to the prevalence of the disease. objective: to determine the diagnostic accuracy of the breath test, serology and rapid urease test, considering gastric biopsy with giemsa stain as the gold standard in hp-infected subjects with uninvestigated dyspepsia. methods: eighty four subjects (64 women, mean age 45 years) who were r ... | 2011 | 22188957 |
| Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with MAPK-activating properties. | Pathogenic Helicobacter pylori strains can selectively activate epithelial MAPK signaling pathways linked with disease. We now demonstrate that H. pylori-induced hemolysis is strain-specific and is mediated by phospholipases PldA1 and PldD. Inactivation of PldD inhibited ERK 1/2 activation, indicating that H. pylori hemolytic phospholipases also harbor MAPK-activating properties. | 2011 | 22205825 |
| Host response to the presence of Helicobacter spp. DNA in the liver of patients with chronic liver diseases. | Literature data indicate an association between the presence of Helicobacter spp. in the liver and the development of hepatocellular carcinoma (HCC). However, the role of H. pylori infections in chronic liver diseases (CLD) remains controversial. The aim of this study was to detect Helicobacter spp. DNA in patients with CLD, and to investigate the host response to the presence of the bacterium in the liver. Helicobacter spp. DNA was detected in 59% samples. H.pylori was the most prevalent specie ... | 2011 | 21905637 |
| [Is antiviral therapy in gastroduodenal pathology necessary?]. | Mucous membrane of the gastroduodenal region of 104 patients with different pathologies (gastritis and erosive ulcerative alterations) was investigated by polymerase chain reaction (PCR). Examination of the biopsy material revealed frequent occurrence of pathogenic strains of Helicobacter pylori (up to 80%) and Herpesviridae (EBV, HHV 6, HHV 7, HHV 8) in various combinations. In such cases it is necessary to use adequate antibacterial and antiviral therapy with individual choice of immunomodulat ... | 2011 | 22145230 |
| Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population. | To evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori (H. pylori) infection, H. pylori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient's life. | 2011 | 22180710 |
| immunological features and the ability of inhibitory effects on enzymatic activity of an epitope vaccine composed of cholera toxin b subunit and b cell epitope from helicobacter pylori urease a subunit. | epitope vaccine based on urease of helicobacter pylori is a promising option for prophylactic and therapeutic vaccination against h. pylori infection. in this study, we constructed an epitope vaccine with mucosal adjuvant cholera toxin b subunit (ctb) and an epitope (urea(183-203)) of h. pylori urease a subunit named ctb-ua. the ctb-ua fusion protein was expressed in escherichia coli, and the purified protein was used for intraperitoneal immunization experiments in balb/c mice. the experimental ... | 2011 | 22134639 |
| lipopolysaccharide structures of helicobacter pylori wild-type strain 26695 and 26695 hp0826::kan mutant devoid of the o-chain polysaccharide component. | we describe a re-investigation of the structure of the lipopolysaccharide (lps) from helicobacter pylori genomic strain 26695 and its corresponding hp0826::kan mutant lacking the o-chain component based on the in-depth nmr analysis of the oligosaccharide products obtained through the use of various degradation procedures performed on the purified lps from both strains, as well as ce-ms data. new structural evidence indicates the presence of the linear arrangement of glucan and heptan portions of ... | 2011 | 21903201 |
| helicobacter pylori-induced thrombocytosis clinically indistinguishable from essential thrombocythemia. | 2011 | 22204454 | |
| pcr in helicobacter spp. diagnostic in extragastric malignancies of digestive system. | recognition of helicobacter pylori as an important factor in genesis of gastric adenocarcinoma lead to a large number of studies concerning potential role of helicobacter spp. in the development of extragastric digestive malignancies. the serological studies indicated possible localizations in the digestive system being from interest in enlightening helicobacter spp. carcinogenic potential. the pcr obtruded itself as a gold standard in proving existence of actual correlation. in this review, the ... | 2011 | 22081011 |
| [reactive changes of human gastric mucosa infected with helicobacter pylori in the aspect of genetic characteristic of host inflammatory response]. | the aim of this study was to determine the morphological changes of human gastric mucosa infected with helicobacter pylori (hp) depending on polymorphism of the genes coding both interleukin-1beta and interleukin-1 receptor antagonist. 106 juveniles with hp-induced chronic gastritis were studied along with 44 juveniles with gastritis, not associated with hp. in patients with hp-associated gastritis, the significant increase in epithelial proliferation and apoptosis indexes was observed. epitheli ... | 2011 | 21866808 |
| Can a Strychnos species be used as antiulcer agent? Ulcer healing action from alkaloid fraction of Strychnos pseudoquina St. Hil. (Loganiaceae). | Strychnos pseudoquina St. Hil. (Loganiaceae) is one Brazilian native medicinal species described in the first edition of the Brazilian Official Pharmacopoeia in 1929. This medicinal plant, popularly known as "quina-quina", "quina-branca" or "casca aromatica was very commonly used in folk medicine in tea form obtained from the bark and/or leaves as tonic, antipyretic, antimalarial and mainly against diseases of the liver, spleen and stomach. | 2011 | 21959182 |
| Regular arrangement of collecting venules: Does patient age affect its accuracy? | To address the diagnostic value of the regular arrangement of collecting venules (RAC) among old age patients. | 2011 | 21860679 |
| Helicobacter pylori and Oral Cancer: Possible Association in a Preliminary Case Control Study. | Oral cancer is the most common cancer diagnosed in Indian men and is the leading cause of cancer deaths. Helicobacter pylori have been reported to be present in 0-40% of the cases with head neck cancer. A higher percentage has been identified in laryngeal and pharangeal cancer. We here carried out a hospital-based, case- control study of 20 patients with newly diagnosed oral cancer and 20 healthy controls without any cancer to evaluate associations between H pylori infection and oral cancer usin ... | 2011 | 21875292 |