Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| cell and tissue interactions of treponema pallidum in primary and secondary syphilitic skin lesions: an ultrastructural study of serial sections. | there are limited reports on the ultrastructure of syphilis skin lesions. the aim of this study has been to perform an electron microscopic investigation of the morphology and the tissue distribution of treponemes in primary and secondary cutaneous lesions. three cases of primary syphilitic chancre and one case of secondary syphilis were included. prominent epidermal abnormalities in the primary chancre and a perivascular inflammatory infiltrate in the secondary lesion were found by light micros ... | 2011 | 21736426 |
| alzheimer's disease - a neurospirochetosis. analysis of the evidence following koch's and hill's criteria. | abstract: it is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. recently it has been suggested that various types of spirochetes, in an analogous way to treponema pallidum, could cause dementia and may be involved in the pathogenesis of alzheimer's disease (ad). here, we review all data available in the literature on the detection of spirochetes in ad and critically analyze the association and causa ... | 2011 | 21816039 |
| synergistic virulence of porphyromonas gingivalis and treponema denticola in a murine periodontitis model. | chronic periodontitis is characterized by the destruction of the tissues supporting the teeth and has been associated with the presence of a subgingival polymicrobial biofilm containing porphyromonas gingivalis and treponema denticola. we have investigated the potential synergistic virulence of p. gingivalis and t. denticola using a murine experimental model of periodontitis. an inoculation regime of four intra-oral doses of 1 +ù 10(10) p. gingivalis cells induced significant periodontal bone lo ... | 2011 | 21729244 |
| target region selection is a critical determinant of community fingerprints generated by 16s pyrosequencing. | pyrosequencing of 16s rrna genes allows for in-depth characterization of complex microbial communities. although it is known that primer selection can influence the profile of a community generated by sequencing, the extent and severity of this bias on deep-sequencing methodologies is not well elucidated. we tested the hypothesis that the hypervariable region targeted for sequencing and primer degeneracy play important roles in influencing the composition of 16s pyrotag communities. subgingival ... | 2011 | 21738596 |
| hiv, sti prevalence and risk behaviours among women selling sex in lahore, pakistan. | abstract: background: more than 340 million cases of curable sexually transmitted infections (stis) were estimated to have occurred worldwide in 1995. previous studies have shown that the presence of other concomitant stis increases the likelihood of hiv transmission. the first national study of stis conducted in pakistan in 2004 revealed a high burden of stis among women selling sex. the hiv epidemic in pakistan has thus far followed the "asian epidemic model". earlier studies among women selli ... | 2011 | 21569319 |
| metabolic engineering of cyanobacteria for 1-butanol production from carbon dioxide. | production and chemicals or fuels directly from co(2) is an attractive approach to solving the energy and environmental problems. 1-butanol, a chemical feedstock and potential fuel, has been produced by fermentation of carbohydrates, both in native clostridium species and various engineered hosts. to produce 1-butanol from co(2), we transferred a modified coa-dependent 1-butanol production pathway into a cyanobacterium, synechococcus elongatus pcc 7942. we demonstrated the activity of each enzym ... | 2011 | 21569861 |
| malignant syphilis with ocular involvement in an hiv-infected patient. | malignant syphilis is now considered a rare disease, more commonly affecting individuals with poor health, malnutrition or hiv infection. we present a 34-year-old man with hiv infection who developed multiple atypical cutaneous ulcerations, leonine facies, a scleral nodule and keratitis with visual loss. the diagnosis of malignant syphilis was delayed due to the insidious presentation, but was confirmed via immunohistochemical (ihc) staining with anti-treponema antibodies of a skin biopsy. signi ... | 2011 | 21571984 |
| risk of sexually transmitted infections and violence among indoor-working female sex workers in london: the effect of migration from eastern europe. | objectives to examine risk factors associated with hiv and sexually transmitted infections (stis) and experience of physical and sexual violence among sex workers in london, with a particular focus on differences in risk between migrants from eastern europe (ee) or the former soviet union (fsu) and uk-born sex workers. methods the authors conducted a cross-sectional survey of sex workers born in the uk, ee or fsu (n=268), collecting behavioural data, testing for antibodies to hiv and treponema p ... | 2011 | 21572111 |
| comparative fecal metagenomics unveils unique functional capacity of the swine gut. | abstract: background: uncovering the taxonomic composition and functional capacity within the swine gut microbial consortia is of great importance to animal physiology and health as well as to food and water safety due to the presence of human pathogens in pig feces. nonetheless, limited information on the functional diversity of the swine gut microbiome is available. results: analysis of 637, 722 pyrosequencing reads (130 megabases) generated from yorkshire pig fecal dna extracts was performed ... | 2011 | 21575148 |
| [gastric syphilis: report of a case]. | 2011 | 21575398 | |
| disruption of a type ii endonuclease (tde0911) enables treponema denticola atcc 35405 strain to accept an unmethylated shuttle vector. | the oral spirochete treponema denticola is associated with human periodontal disease. t. denticola atcc 35405 (td(35405)) and 33520 (td(33520)) are two routinely used laboratory strains. compared to td(33520), td(35405) is more virulent but less accessible to genetic manipulations. for instance, the shuttle vectors of td(33520) cannot be transformed into td(35405). the lack of a shuttle vector has been a barrier to study the biology and virulence of td(35405). in this report, we hypothesize that ... | 2011 | 21602384 |
| identification of periodontal pathogens in healthy periimplant sites. | : the aim of this study was to evaluate the presence of periodontopathogens in subgingival periimplant sites in partially edentulous patients using polymerase chain reaction procedures, with regard to areas with clinical and radiographic signs of health and areas presenting periimplant disease. | 2011 | 21613949 |
| evaluation of two automated chemiluminescence immunoassays, the liaison treponema screen and the architect syphilis tp, and the treponema pallidum particle agglutination test for laboratory diagnosis of syphilis. | abstract background: automated treponema pallidum-specific chemiluminescence immunoassays (clia) run on random-access analyzers allow for rapid diagnosis of syphilis infection. methods: we evaluated the liaison treponema screen (lia) and the architect syphilis tp (arch) in comparison to the treponema pallidum particle agglutination (tppa) test, as a screening test for syphilis. we performed a prospective study using 577 sera submitted for diagnosis of syphilis, including 318 samples from pregnan ... | 2011 | 21619473 |
| syphilitic gastritis mimicking gastric neoplasms. | 2011 | 21622037 | |
| riboswitch regulates a thiamine pyrophosphate (tpp) abc transporter of the oral spirochete treponema denticola. | thiamine pyrophosphate (tpp), a biologically active form of thiamine (vitamin b1), is an essential cofactor in all living systems. microorganisms either synthesize tpp via de novo biosynthesis pathways or uptake exogenous thiamine from the environment via specific transporters. the oral spirochete treponema denticola is an important pathogen that is associated with human periodontal diseases. it lacks a de novo tpp biosynthesis pathway and needs exogenous tpp for the growth, suggesting that it m ... | 2011 | 21622748 |
| autoimmune bullous diseases the spectrum of infectious agent antibodies and review of the literature. | pemphigus and bullous pemphigoid are two autoimmune diseases that have a similar pathogenesis. both have a genetic predisposition which promotes the production of auto-antibodies targeted against different components of the epidermal desmosome and hemidesmosome. environmental factors play an important role in the pathogenesis of this autoimmune disease. among these, the role of infectious agents was debated as a causative factor. we sought to determine a possible connection between various infec ... | 2011 | 21527361 |
| effect of periodontopathogen lipopolysaccharides and proinflammatory cytokines on cd46, cd55, and cd59 gene/protein expression by oral epithelial cells. | membrane-anchored complement regulatory proteins (crps), including cd46, cd55, and cd59, protect host cells from complement attack. in the present study, we investigated whether periodontopathogen lipopolysaccharide and proinflammatory cytokines modulate crp gene/protein expression in human oral epithelial cells. the lipopolysaccharide of treponema denticola and tannerella forsythia were the most potent for increasing the gene expression of cd55 and cd59, and to a lesser extent cd46, after a 48- ... | 2011 | 21545652 |
| treponema denticola pure is a bacterial air carboxylase. | de novo purine biosynthesis proceeds by two divergent paths. in bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (air) is converted to 4-carboxy-air (cair) by two enzymes: n(5)-carboxy-air (n(5)-cair) synthetase (purk) and n(5)-cair mutase (class i pure). in animals, the conversion of air to cair requires a single enzyme, air carboxylase (class ii pure). the cair carboxylate derives from bicarbonate or co(2), respectively. class i pure is a promising antimicrobial target. class i an ... | 2011 | 21548610 |
| challenges in recognition and diagnosis of yaws in children in papua new guinea. | a global resurgence of yaws in developing countries highlights the need for reliable diagnostic criteria for this neglected infection. we conducted a clinical and serologic survey of 233 children less than 15 years of age who had clinically suspected yaws. a total of 138 (59%) cases were confirmed serologically, and 10 of 12 primary stage cases showed positive results for treponema pallidum by a polymerase chain reaction assay that has not yet been validated for identification of yaws. a high pr ... | 2011 | 21734134 |
| probing individual environmental bacteria for viruses by using microfluidic digital pcr. | viruses may very well be the most abundant biological entities on the planet. yet neither metagenomic studies nor classical phage isolation techniques have shed much light on the identity of the hosts of most viruses. we used a microfluidic digital polymerase chain reaction (pcr) approach to physically link single bacterial cells harvested from a natural environment with a viral marker gene. when we implemented this technique on the microbial community residing in the termite hindgut, we found g ... | 2011 | 21719670 |
| first report on sexually transmitted infections among trans (male to female transvestites, transsexuals, or transgender) and male sex workers in argentina: high hiv, hpv, hbv, and syphilis prevalence. | due to the scarce data on the prevalence of sexually transmitted infections (stis) among male-to-female trans-sex workers (tsw) and male sex workers (msw) in argentina, the present study aimed to estimate the incidence of human immunodeficiency virus (hiv), and the prevalence of hiv, hepatitis b virus (hbv), hepatitis c virus (hcv), and treponema pallidum. human papillomavirus (hpv) and chlamydia trachomatis infections were tested among tsw. | 2011 | 21742530 |
| geographical differences in autoantibodies and anti-infectious agents antibodies among healthy adults. | much is known about the geoepidemiology of defined autoimmune diseases (ad); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. the aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. sera samples from 557 healthy donors were obtained at six centers located in dif ... | 2011 | 21229335 |
| evaluation of an igm/igg sensitive enzyme immunoassay and the utility of index values for the screening of syphilis infection in a high-risk population. | increasing interest in the use of enzyme immunoassays (eia) for syphilis screening has generated a considerable need for data on the performance of such tests. | 2011 | 21233789 |
| contaminant treponema-positive bacteria in cutaneous biopsies with an infiltrate rich in plasma cells. | 2011 | 21242758 | |
| prognosis of periodontitis recurrence after intensive periodontal treatment using examination of serum igg antibody titer against periodontal bacteria. | chronic periodontitis is associated with systemic diseases such as atherosclerosis. in this study, we evaluated the efficacy of serum igg antibody titer to periodontal bacteria for prognosis of periodontitis recurrence during supportive periodontal therapy (spt) phase. the 139 patients during spt phase were selected and divided to two groups as follows: "stable" and "recurrence" group at spt phase for case-control study: "high igg titer" and "normal igg titer" group before transition to spt phas ... | 2011 | 21254239 |
| molecular survey of atheromatous plaques for the presence of dna from periodontal bacterial pathogens, archaea and fungi. | chronic infections, such as periodontitis, have been associated with the development and progression of atherosclerosis. the mechanisms through which this occurs have yet to be elucidated. this study was carried out to detect periodontopathic bacteria as well as archaea and fungi in atheromatous plaques and search for factors associated with their occurrence in atheromas. | 2011 | 21261623 |
| polymicrobial infection with periodontal pathogens specifically enhances microrna mir-146a in apoe-/- mice during experimental periodontal disease. | porphyromonas gingivalis, treponema denticola, and tannerella forsythia are periodontal pathogens associated with the etiology of adult periodontitis as polymicrobial infections. recent studies demonstrated that oral infection with p. gingivalis induces both periodontal disease and atherosclerosis in hyperlipidemic and proatherogenic apoe(-/-) mice. in this study, we explored the expression of micrornas (mirnas) in maxillas (periodontium) and spleens isolated from apoe(-/-) mice infected with p. ... | 2011 | 21263019 |
| serum antibodies against genitourinary infectious agents in prostate cancer and benign prostate hyperplasia patients: a case-control study. | infection plays a role in the pathogenesis of many human malignancies. whether prostate cancer (pca) - an important health issue in the aging male population in the western world - belongs to these conditions has been a matter of research since the 1970 s. persistent serum antibodies are a proof of present or past infection. the aim of this study was to compare serum antibodies against genitourinary infectious agents between pca patients and controls with benign prostate hyperplasia (bph). we hy ... | 2011 | 21291519 |
| [female patient with sjoegren's syndrome and cardiolipin antibodies]. | cross-reactions with cardiolipin antibodies and serological lues tests are common. we examined a 37 year old patient with neurological symptoms and signs of sjoegren's syndrome and secondary antiphospholipid syndrome. but the lues screening test was also positive and the serological tests following approved the lues infection. when an autoimmune disease is diagnosed with the presence of cardiolipin antibodies we recommend also testing for treponema pallidum as a possible disease. | 2011 | 21305258 |
| secondary syphilis presenting as rash and annular hyperkeratotic lesions. | 2011 | 21306931 | |
| discordant results from reverse sequence syphilis screening--five laboratories, united states, 2006-2010. | cdc recommends syphilis serologic screening with a nontreponemal test, such as the rapid plasma reagin (rpr) or venereal disease research laboratory (vdrl) test, to identify persons with possible untreated infection; this screening is followed by confirmation using one of several treponemal tests. recently, the availability of automatable treponemal enzyme and chemiluminescence immunoassays (eia/cia) has led some laboratories to adopt a reverse sequence of screening in which a treponemal eia/cia ... | 2011 | 21307823 |
| detection of salmonella typhi agglutinins in sera of patients with other febrile illnesses and healthy individuals. | widal test is frequently applied for the detection of salmonella agglutinins to diagnose salmonella enterica serotype typhi infection. there are however a number of controversies challenging the diagnostic utility of this test. this study was performed to determine the prevalence of salmonella agglutinins in patients with other febrile illnesses and healthy blood donors. | 2011 | 21311155 |
| seroprevalence of hiv-1, hbv, htlv-1 and treponema pallidum among pregnant women in a rural hospital in southern ethiopia. | human immunodeficiency virus type 1 (hiv-1), hepatitis b virus (hbv), human t-cell lymphotropic virus type 1 (htlv-1) and treponema pallidum represent major public health problems in sub-saharan countries. these infections can be transmitted from mother to children and may cause severe morbidities in their offspring. ethiopia is among the countries where hiv-1, hbv and t. pallidum infections are highly prevalent. however, information on seroprevalence of these infections among antenatal care att ... | 2011 | 21330196 |
| [immulite 2000 syphilis screen assay in syphilis screening]. | 2011 | 21334111 | |
| syringomyelia associated with syphilitic spinal meningitis: real complication or possible association? | the study has been designed as a case report. | 2011 | 21339760 |
| effect of teenage smoking on the prevalence of periodontal bacteria. | the aim of our study was to investigate how teenage smoking affects the prevalence of periodontal bacteria and periodontal health with the hypothesis that smoking increases the prevalence of the bacteria. oral health of 264 adolescents (15- to 16-year-olds) was clinically examined, and their smoking history was recorded. the participants also filled in a structured questionnaire recording their general health and health habits. pooled subgingival plaque samples were taken for polymerase chain re ... | 2011 | 21340603 |
| [evaluation of a syphilis testing algorithm using a treponemal test for screening]. | traditional testing algorithm for syphilis is initial screening with nontreponemal tests, then retesting positive samples for confirmation using a specific treponemal test. commercial treponemal tests those are more sensitive than nontreponemal tests and suitable for automation are now commercially available to screen syphilis. although the treponemal tests are offered as the first choice for syphilis screening by some of the guidelines, to date there is no consensus on recommendations in guidel ... | 2011 | 21341164 |
| [an irishman with fever and skin lesions]. | 2011 | 21345526 | |
| treponema-specific tests for serodiagnosis of syphilis: comparative evaluation of seven assays. | the diagnosis of syphilis is challenging and often relies on serologic tests to detect treponemal or nontreponemal antibodies. recently, the centers for disease control and prevention and the association of public health laboratories proposed an update to the syphilis serology testing algorithm, in which serum samples are first tested using a treponema-specific test and positive samples are analyzed with a nontreponemal assay. the goal of this study was to compare the performance of seven trepon ... | 2011 | 21346050 |
| osteoperiostitis in early yaws: case series and literature review. | we describe the clinical and radiological manifestations and outcome after treatment of 7 children who received a diagnosis of early yaws osteoperiostitis. osteoperiostitis occurred some weeks after the primary infection, and the most common finding was hypertrophic periostitis of long bones. all treated patients had excellent responses to benzyl-penicillin therapy. | 2011 | 21367729 |
| single nodular lesion on the scalp: a quiz. diagnosis: nodular secondary syphilis. | 2011 | 21369679 | |
| evaluation of three serological tests manufactured in belarus for the diagnosis of syphilis. | the performance of three serological tests manufactured in belarus for the diagnosis of syphilis, i.e. a microprecipitation reaction (mpr) and two enzyme-linked immunosorbent assays (elisas) were compared with internationally recognized assays, namely the rapid plasma reagin test and the treponema pallidum passive particle agglutination assay (tppa). sera from 392 consecutive patients attending brest (belarus) regional dermatovenereological dispensaries were tested. the sensitivity of the mpr te ... | 2011 | 21369683 |
| [neurosyphilis: unexpected reunion with an old acquaintance]. | a 45-year-old man was admitted to a psychiatric hospital with confusion and disorientation; he was suspected of having korsakoff syndrome. he was known to have a history of alcohol abuse, complicated by epileptic fits, and to have had a recent ischaemic cerebrovascular attack. unexpectedly, screening for syphilis turned out to be positive. examination of the cerebrospinal fluid led to the diagnosis of neurosyphilis. most neurological and psychiatric symptoms disappeared after treatment with anti ... | 2011 | 21319069 |
| rna-seq reveals cooperative metabolic interactions between two termite-gut spirochete species in co-culture. | the hindguts of wood-feeding termites typically contain hundreds of microbial species. together with their insect host, these gut microbes degrade lignocellulose into usable catabolites. although past research revealed many facets of the stepwise flow of metabolites in this scheme, not much is known about the breadth of interactions occurring between termite-gut microbes. most of these microbes are thought to depend on, and to have co-speciated with, their host and each other for millions of yea ... | 2011 | 21326336 |
| evaluation of a colloidal gold immunochromatography assay in the detection of treponema pallidum specific igm antibody in syphilis serofast reaction patients: a serologic marker for the relapse and infection of syphilis. | syphilis remains as a worldwide public health problem; hence, it is necessary to develop a new diagnostic approach that is easier and faster than conventional tests. a new testing method to detect treponema pallidum igm (tp-igm), named colloidal gold immunochromatography assay (gica), is presented in place of fluorescent treponemal antibody absorption (fta-abs). tp-igm was detected using gica developed on syphilis-specific recombinant proteins tpn17 and tpn47. the fta-abs igm test was set as the ... | 2011 | 21388769 |
| association of red complex, a. actinomycetemcomitans and non-oral bacteria with periodontal diseases. | pathogens related to systemic infections have been detected in the periodontal microbiota. the relationship amongst these pathogens, periodontal bacteria and periodontal clinical status is poorly understood. this study evaluated the association amongst red complex, a. actinomycetemcomitans (a.a) and non-oral pathogenic bacteria in subjects with good periodontal health (ph), gingivitis (g), chronic (cp) and aggressive (ap) periodontitis. | 2011 | 21397893 |
| clustering of subgingival microbial species in adolescents with periodontitis. | it has become increasingly recognized that groups of microorganisms interact within the subgingival plaque of adult subjects with periodontitis. it is much less clear, however, whether the consortia of microorganisms associated with periodontitis are different in early and more advanced cases of periodontitis. to investigate this point further, subgingival plaque was collected from six sites in 87 adolescents with periodontitis and 73 controls and the samples were analyzed for the detection of 1 ... | 2011 | 21410554 |
| comparative analysis of immunohistochemistry, polymerase chain reaction and focus-floating microscopy for the detection of treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilis. | the incidence of syphilis is increasing in many parts of the world including a re-emergence in western europe and north america. depending on the disease stage, direct detection of treponema pallidum in mucocutaneous lesions of syphilis may be difficult and histopathological findings are not always straightforward. thus, the correct histological diagnosis may be challenging. | 2011 | 21410678 |
| association of the hla-drb1 locus with syphilis in a chinese population. | syphilis is a sexually transmitted infection (sti) caused by the treponema pallidum subspecies pallidum spirochete bacterium. the association of human leukocyte antigen (hla) with syphilis has been reported in several populations, but not in the chinese population. furthermore, serology methods have mostly been used in previous studies investigating the association between stis and hla alleles. the objective of this study was to analyze the association of the hla-drb1 alleles and susceptibility ... | 2011 | 21411354 |
| treponema infection associated with genital ulceration in wild baboons. | the authors describe genital alterations and detailed histologic findings in baboons naturally infected with treponema pallidum. the disease causes moderate to severe genital ulcerations in a population of olive baboons (papio hamadryas anubis) at lake manyara national park in tanzania. in a field survey in 2007, 63 individuals of all age classes, both sexes, and different grades of infection were chemically immobilized and sampled. histology and molecular biological tests were used to detect an ... | 2011 | 21411621 |
| low prevalence of syphilis in brazilian inmates. | 2011 | 21412600 | |
| spirochaetes: past lessons to future directions. | 2011 | 21414080 | |
| new insights into the emerging role of oral spirochaetes in periodontal disease. | spirochaetes are prominent in the polymicrobial infections that cause periodontal diseases. periodontitis is a chronic inflammatory condition of the periodontium, characterized by proinflammatory soft tissue damage and alveolar bone loss. treponema denticola is the most well-understood oral spirochaete, expressing a wealth of virulence factors that mediate tissue penetration and destruction as well as evasion of host immune responses. this review focuses on emerging knowledge of virulence mechan ... | 2011 | 21414084 |
| laryngeal syphilis: a case report. | syphilis is a sexually transmitted disease caused by the spirochete treponema pallidum. the complexity of the disease gained it the moniker "the great imitator"; it was william osler who said, "he who knows syphilis, knows medicine." in 1866, patrick watson of edinburgh, scotland, reported a case of a 36-year-old man in whom syphilis destroyed the larynx.(1) the diagnosis was made postmortem. it was once believed that this was the first reported total laryngectomy, but the credit should actually ... | 2011 | 21422316 |
| [incidence and risk factors of hiv and syphilis seroconversion among men who have sex with men in beijing]. | to study the incidence and risk factors of hiv and syphilis seroconversion among men who have sex with men (msm) in beijing. | 2011 | 21426789 |
| detection of treponema pallidum in aqueous humor by real-time polymerase chain reaction. | to report the additional clinical value of real-time polymerase chain reaction (pcr) in the detection of treponema pallidum in aqueous humor. | 2011 | 21428753 |
| bacterium's discovery should be clarified. | 2011 | 21442784 | |
| molecular signaling mechanisms of the periopathogen, treponema denticola. | in the healthy subgingiva, oral treponemes account for a small percentage of the total bacteria. however, in diseased periodontal pockets, treponemes thrive and become a dominant component of the bacterial population. oral treponemes are uniquely adept at capitalizing on the environmental conditions that develop with periodontal disease. the molecular basis of adaptive responses of oral treponemes is just beginning to be investigated and defined. the completion of several treponeme genome sequen ... | 2011 | 21447698 |
| [evaluation of latex agglutination test for anti-treponemal antibody in comparison with chemical luminescence tests]. | the performance of a latex agglutination test (mediace tpla) in the detection of anti-treponemal antibody was evaluated in comparison with chemical luminescence tests (lumipulsii-n and architect tpab) in 346 cases. anti-treponemal antibody was further determined by immunochromatography and immunoblotting tests and additionally evaluated by a serological test for syphilis with lipoidal antigens. the total concordance rate between the latex agglutination test and chemical luminescence tests ranged ... | 2011 | 21476292 |
| false positive lyme serology due to syphilis: report of 6 cases and review of the literature. | a 44-year-old man presented with visual field defects. ophthalmoscopy revealed papilloedema of the left eye. neuroborreliosis was suspected and serum was positively being tested using vidas* lyme screen ii (biomerieux vitek inc). however, confirmatory testing using the borrelia vlse c6 titre was negative. western blotting on serum and cerebrospinal fluid could not confirm the possible diagnosis of neuroborreliosis. vdrl and tppa testing was positive, and finally, the diagnosis of neurosyphilis w ... | 2011 | 21485767 |
| oral health behaviors, periodontal disease and pathogens in preeclampsia: a case-control study in korea. | background: the aim of this study was to confirm the association among oral health behaviors, periodontitis and preeclampsia in korean women. methods: this study was designed as a case-control study. sixteen preeclamptic and forty eight non-preeclamptic women after delivery were included in this study from november 2007 to january 2010. information on demographics, health behaviors, obstetric and systemic disease that may influence periodontal condition and preeclampsia was collected. full mouth ... | 2011 | 21486182 |
| microbial shifts during dental biofilm re-development in the absence of oral hygiene in periodontal health and disease. | uzel ng, teles fr, teles rp, song xq, torresyap g, socransky ss, haffajee ad. microbial shifts during dental biofilm re-development in the absence of oral hygiene in periodontal health and disease. j clin peridontol 2011; doi: 10.1111/j.1600-051x.2011.01730.x. abstract: aim: to monitor microbial shifts during dental biofilm re-development. materials and methods: supra- and subgingival plaque samples were taken separately from 28 teeth in 38 healthy and 17 periodontitis subjects at baseline and i ... | 2011 | 21488936 |
| tp0326, a treponema pallidum β-barrel assembly machinery a (bama) orthologue and rare outer membrane protein. | definitive identification of treponema pallidum rare outer membrane proteins (omps) has long eluded researchers. tp0326, the sole protein in t. pallidum with sequence homology to a gram-negative omp, belongs to the bama family of proteins essential for om biogenesis. structural modelling predicted that five polypeptide transport-associated (potra) domains comprise the n-terminus of tp0326, while the c-terminus forms an 18-stranded amphipathic β-barrel. circular dichroism, heat modifiability by s ... | 2011 | 21488980 |
| a novel approach in the use of subgingival controlled-release delivery of chlorhexidine in chronic periodontitis: a randomized clinical trial. | background: we aimed to analyze clinical, microbiological, and serological effects of chlorhexidine (chx) chips used as subgingival controlled-release-delivery-device before and immediately after scaling and root-planing (srp). methods: 24 patients presenting with at least 12 teeth with ppd ≥5 mm and bop were assigned in test or control groups. after prophylaxis, chx chips (test) or placebo chips (control) were placed in pockets with ppd ≥5mm. ten days later srp was performed in all teeth with p ... | 2011 | 21491990 |
| risky sexual behavior among patients in turkey with bipolar disorder, schizophrenia, and heroin addiction. | aim. risky sexual behavior associated with such sexually transmitted infections (stis) as hepatitis b and c, herpes, treponema pallidum, and neisseria gonorrhoeae, is more frequent among psychiatric patients and parenteral drug abusers than the general population. the aim of this study was to investigate risky sexual behavior in psychiatric outpatients diagnosed with schizophrenia (sch), bipolar disorder, and heroin addiction (ha), and to compare them with those observed in healthy controls. me ... | 2011 | 21492406 |
| association between bovine digital dermatitis treponemes and a range of 'non-healing' bovine hoof disorders. | this study describes the association between bovine digital dermatitis (bdd) treponemes and three 'non-healing' bovine hoof horn lesions, namely, 'toe necrosis' (tn), 'non-healing white line disease' (nhwld) and 'non-healing sole ulcer' (nhsu), which are disorders that involve penetration through the horn capsule to involve the corium. in this study, these non-healing disorders (n=44) were identified as foot lesions that exhibited a topical granular appearance, exuded a typical pungent smell, we ... | 2011 | 21493554 |
| higoumenakis' sign in the diagnosis of congenital syphilis in anthropological specimens. | higoumenakis' sign (hs) is a diagnostic criterion referring to the enlargement of the sternal end of the (right) clavicle, frequently observed in patients with late congenital syphilis. although indexed for several years in clinical medicine textbooks, it has not been extensively applied for the diagnosis of congenital syphilis among anthropological specimens. this is highly significant, since the other major palaeopathology findings refer almost exclusively to the skull and diagnosis thus becom ... | 2011 | 21498006 |
| [meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. | authors report a case of a 35-year-old male with right-sided mild paresis, incontinence, dysexecutive syndrome, short-term memory loss and behavioral changes. bilateral cerebral infarcts in the region of the caudate nuclei and the adjacent white matter were proved by brain mri and multiple stenoses of the branches of willis-circle were confirmed by mr angiography. elevated protein level and pleocytosis were found in the cerebrospinal fluid with intrathecal igg synthesis. serum rapid plasma reagi ... | 2011 | 21498167 |
| gingival tissue transcriptomes in experimental gingivitis. | jönsson d, ramberg p, demmer rt, kebschull m, dahlén g, papapanou pn. gingival tissue transcriptomes in experimental gingivitis. j clin periodontol 2011; doi: 10.1111/j.1600-051x.2011.01719.x. abstract: aims: we investigated the sequential gene expression in the gingiva during the induction and resolution of experimental gingivitis. material and methods: twenty periodontally and systemically healthy non-smoking volunteers participated in a 3-week experimental gingivitis protocol, followed by deb ... | 2011 | 21501207 |
| endemic treponemal infections in international adoptees and immigrant children: how common are they? | 2011 | 21504459 | |
| syphilitic aortitis complicated by multiple aortic aneurysms: findings of multidetector ct. | we report a case of syphilitic aortitis complicated by multiple aortic aneurysms in a 50-year-old man with elevated rapid plasma reagin titer of 1:128 and positive treponema pallidum particle agglutination test. 256-slice mdct depicted two saccular aneurysms in the descending thoracic aorta with a markedly thick mural thrombus causing the trachea and esophagus to shift to the right. thickening of the aortic wall was also noted. stenting of the proximal descending thoracic aortic aneurysm and aor ... | 2011 | 21505957 |
| viral-bacterial associations in acute apical abscesses. | objective: viral-bacterial and bacterial synergism have been suggested to contribute to the pathogenesis of several human diseases. this study sought to investigate the possible associations between 9 candidate endodontic bacterial pathogens and 9 human viruses in samples from acute apical abscesses. study design: dna extracts from purulent exudate aspirates of 33 cases of acute apical abscess were surveyed for the presence of 9 selected bacterial species using a 16s ribosomal rna gene-based nes ... | 2011 | 21507684 |
| inhibition of host- and bacteria-derived proteinases by natural anthocyanins. | santos j, la vd, bergeron c, grenier d. inhibition of host- and bacteria-derived proteinases by natural anthocyanins. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01372.x. © 2011 john wiley & sons a/s background and objectives: host- and bacteria-derived proteinases are considered to play critical roles in periodontitis progression. this study investigated the ability of a blackcurrant extract and its major anthocyanins (cyanidin-3-o-glucoside, cyanidin-3-o-rutinoside and delphinidin-3-o ... | 2011 | 21517858 |
| the evaluation of bacterial flora in progress of peri-implant disease. | background: cumulative interceptive supportive therapy (cist) is currently used as a guideline for treating peri-implant diseases. the objectives of this study were to determine the detection rate and measure the number of periodontopathic bacteria in lesions of different cist levels and thereby characterize peri-implant disease from a bacteriological viewpoint. methods: this study included 105 patients who had both residual natural teeth and implants with peri-implant disease. a total of 105 ... | 2011 | 21623813 |
| experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing. | the pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed. | 2011 | 21625744 |
| crystallization of the factor h-binding protein, fhbb, from the periopathogen treponema denticola. | treponema denticola is a primary etiological agent of periodontal disease. t. denticola evades complement-mediated killing by binding to the host's factor h (fh), a negative regulator of the alternative complement pathway. the t. denticola fh-binding protein has been identified and designated as factor h-binding protein b (fhbb). crystals of recombinant fhbb were obtained by the hanging-drop vapor-diffusion method using sodium citrate and 0.2 m sodium thiocyanate. fhbb crystals diffracted to 1.8 ... | 2011 | 21636910 |
| pregnancy and neonatal outcomes of women with reactive syphilis serology in alberta, 2002 to 2006. | objectives: to describe the maternal characteristics, diagnosis, and pregnancy, and the neonatal outcomes of pregnant women with reactive syphilis serology in a canadian cohort. methods: we conducted a retrospective chart review of pregnant women in alberta with reactive syphilis serology between 2002 and 2006. clinical staging of syphilis in mothers and infants was determined using provincial and national surveillance criteria. results: seventy-five pregnancies met the inclusion criteria. thirt ... | 2011 | 21639965 |
| rapid, progressive neuropathic arthropathy of the hip in a patient co-infected with human immunodeficiency virus, hepatitis c virus and tertiary syphilis: case report. | abstract: background: syphilis is a chronic infection that is classified into three stages. in its tertiary stage, syphilis spreads to the brain, heart and other organs; the lesions may involve the skin, mucous membranes and bones. neuropathic arthropathy associated with tertiary syphilis has rarely been described in europe and its association with hiv-hcv co-infection has not been reported so far. this article reports the case of a man with tertiary syphilis presenting with rapidly evolving neu ... | 2011 | 21645338 |
| complete genome sequence of treponema paraluiscuniculi, strain cuniculi a: the loss of infectivity to humans is associated with genome decay. | treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. it is not infectious to humans, although its genome structure is very closely related to other pathogenic treponema species including treponema pallidum subspecies pallidum, the etiological agent of syphilis. in this study, the genome sequence of treponema paraluiscuniculi, strain cuniculi a, was determined by a combination of several high-throughput sequencing strategies. whereas the overall size (1,133,390 bp), ... | 2011 | 21655244 |
| hepatitis c virus infection and biological false-positive syphilis test: a single-center experience. | rapid plasma regain positive and/or treponema pallidum hemagglutination negative [rpr(+)/tpha(-)] results were designated as biologic false-positive (bfp). there are limited data about bfp reactions against syphilis in patients with hepatitis c virus (hcv) infection. this study aimed to determine the prevalence of bfp reactions for syphilis in patients with hcv infection in a large sample and assess the relationship between bfp reactions and hcv infection. | 2011 | 21813389 |
| images in clinical medicine. syphilitic chancre of the tongue. | 2011 | 21812667 | |
| genomic analysis reveals multiple [fefe] hydrogenases and hydrogen sensors encoded by treponemes from the h(2)-rich termite gut. | we have completed a bioinformatic analysis of the hydrogenases encoded in the genomes of three termite gut treponeme isolates: hydrogenotrophic, homoacetogenic treponema primitia strains zas-1 and zas-2, and the hydrogen-producing, sugar-fermenting treponema azotonutricium zas-9. h(2) is an important free intermediate in the breakdown of wood by termite gut microbial communities, reaching concentrations in some species exceeding those measured for any other biological system. the spirochetes enc ... | 2011 | 21811792 |
| neuroinfection survey at a neurological ward in a brazilian tertiary teaching hospital. | this study was undertaken to characterize the neuroinfection profile in a tertiary neurological ward. | 2011 | 21808869 |
| evaluation of a new multiplex polymerase chain reaction assay stdfinder for the simultaneous detection of 7 sexually transmitted disease pathogens. | we evaluated a new multiplex polymerase chain reaction (mpcr), "stdfinder assay", a novel multiplex ligation-dependent probe amplification (mlpa) assay for the simultaneous detection of 7 clinically relevant pathogens of stds, i.e., neisseria gonorrhoeae, chlamydia trachomatis, trichomonas vaginalis, mycoplasma genitalium, treponema pallidum, and herpes simplex virus type 1 and 2 (hsv-1 and hsv-2). an internal amplification control was included in the mpcr reaction. the limits of detection for t ... | 2011 | 21798683 |
| molecular detection of treponema pallidum sp. pallidum in blood samples of vdrl-seroreactive women with lethal pregnancy outcomes: a retrospective observational study in northern brazil. | introduction: although control measures of maternal and congenital syphilis are available in brazil, difficulties exist within the healthcare network in providing a laboratory diagnosis of the infection during the prenatal period. the objective of this study was to confirm the presence of treponema pallidum by pcr in women with positive vdrl serology and lethal pregnancy outcomes, i.e., abortion, stillbirth and neonatal death. methods: a retrospective study was conducted on vdrlseroreactive wome ... | 2011 | 21789353 |
| [current methods for serological diagnosis of syphilis]. | the paper gives information on novel diagnostic tests based on immunoblotting and immunochromatographic methods used to detect antibodies against treponema pallidum. whether these tests should be incorporated into an algorithm of the current serological diagnosis of syphilis is discussed. | 2011 | 21786613 |
| gc content-independent amino acid patterns in bacteria and archaea. | every organism can be characterized by the amino acid composition of its proteome. so far it was assumed that these compositions are determined by the gc content of the dna or, in some cases, by extreme lifestyles, like thermophily or halophily. here, we focussed our analysis on eight amino acids, each of which is encoded by both, gc and at rich codons, to identify finer amino acid patterns beyond the gc dominance. we investigated the conceptually translated proteomes of 1029 bacterial and archa ... | 2011 | 21780150 |
| evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: a clinical and microbiological study. | to compare the effect of experimental local-drug delivery system containing 2% whole turmeric (gel form) as an adjunct to scaling and root planing (srp) with the effect achieved using srp alone by assessing their respective effects on plaque, gingival inflammation, bleeding on probing pocket depth, relative attachment levels and trypsin-like enzyme activity of "red complex" microorganisms, namely, bacteroides forsythus, porphvromonas gingivalis and treponema denticola. | 2011 | 21772719 |
| detection of periodontal markers in chronic periodontitis. | the aim was to compare the detection frequency of periodontopathogens by using the pado test 4.5 and checkerboard dna-dna hybridization technique in chronic periodontitis patients.thirty patients with chronic periodontitis were tested cross-sectionally with dna/rna oligogenomic probe method (iai pado test 4.5) and dna/dna whole genomic probe (checkerboard) method. samples were taken by two paper points at the deepest site in each of the four quadrants and pooled into one sample for each of the t ... | 2011 | 21769304 |
| an atlas of syphilis in a single case. | 2011 | 21768496 | |
| prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report. | syphilis remains a serious cause of neonatal morbidity and mortality worldwide. in this paper, we describe a case of congenital syphilis that was fully supported by abnormal fetal heart rate patterns and placental histopathological evidence. a 24-year-old para 4 woman, who did not attend antenatal care, was admitted to our hospital with a complaint of abdominal discomfort at an estimated 31-week gestation. fetal heart rate monitoring showed prolonged bradycardia. a neonate weighting 1,423?g with ... | 2011 | 21766037 |
| identification of immunogenic proteins in treponema phagedenis-like strain v1 from digital dermatitis lesions by phage display. | digital dermatitis (dd) is a contagious claw disease causing lameness in cattle, affecting both animal welfare and economics. in this study, shotgun phage display was used to identify immunogenic proteins in a strain (v1) of the treponema phylotype closely related to treponema phagedenis, indicated as a key agent in the pathogenesis of dd. a genomic phage library was constructed and selected against antibodies from a rabbit immunized with live strain v1 bacteria. a homolog to the immunogenic pro ... | 2011 | 21763087 |
| syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy. | syphilis is coming back in the recent a few decades especially in the gay and hiv populations. since syphilis can be "the great mimic" clinically and pathologically, a case report with updated review can be helpful to the medical community. we report, a case of syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy (fnab). the pitfalls associated with the diagnosis of syphilitic lymphadenitis will be discussed. the patient's medical records were reviewed. the pertinent history, cli ... | 2011 | 21761579 |
| getting the measure of syphilis: qpcr to better understand early infection. | objectives until recently, pcr had been used to detect but not quantify treponema pallidum. to understand infection kinetics of this uncultivable organism, a real-time pcr assay was developed to quantify 47 kda membrane lipoprotein gene dna (tpp47). methods assay specificity was determined against dna from humans, skin organisms and sexually transmitted pathogens. tpp47 dna (nichols strain) was used to construct a standard curve for t pallidum quantification. blood and ulcer samples were ... | 2011 | 21752804 |
| yaws in polynesia's wallis and futuna islands: a seroprevalence survey. | we carried out a serological and clinical survey to determine the prevalence and clinical presentation of yaws on two twin islands in polynesia: wallis and futuna. a total of 264 serum samples were tested for specific treponema pallidum haemagglutinations assay and non-specific rapid plasma reagin: 52 were positive for one or both tests; only one young adult had skin lesion consistent with yaws; and there were no observed cases of secondary or tertiary yaws. our results contrast with findings in ... | 2011 | 21750592 |
| analysis of the peri-implant microbiota in 90 dental implants and its relationship to crevicular fluid volume. | objective: to evaluate the presence within the peri-implant sulcus of tannerela forsythia (tf), porphyromonas gingivales (pg), treponema denticola (td) and aggregatibacter actinomycetemcomitans (aa), and relate these bacteria to the peri-implant crevicular fluid volume (picfv). material and method: a prospective and cross-sectional clinical case series study was made. for the measurement of crevicular fluid, use was made of the periotron® 8000 (proflow incorporated. new york, usa), measuring the ... | 2011 | 21743411 |
| clinical spectrum of neurosyphilis in north east india. | background : symptomatic neurosyphilis (ns) can have varied syndromic presentations: meningitis, meningovascular and parenchymatous involvement. aims : to evaluate the different types of clinical syndrome of ns in a tertiary care hospital. material and methods : this was a study of clinical profile of 16 patients with ns, seen in between august 2008 and december 2010. results : there were 13 male and 3 female patients in the age group of 23-48 years. the clinical syndromes included: neuropsychia ... | 2011 | 21743160 |
| virology. revealing virus-host interplay. | 2011 | 21719664 | |
| seroprevalence of human immunodeficiency virus, hepatitis b and c viruses and syphilis among blood donors in koudougou (burkina faso) in 2009. | background: the high prevalence of numerous transfusion-transmitted infectious diseases such as human immunodeficiency virus (hiv), hepatitis b virus (hbv), hepatitis c virus (hcv) and syphilis in sub-saharan africa affects the safety of blood for recipients. this study was undertaken with the aim of determining the seroprevalence of hiv, hcv, hbv, syphilis and socio-demographic risk factors associated with blood donation in a new regional blood transfusion centre in burkina faso. material and m ... | 2011 | 21839011 |
| the risk factor profile of women with secondary infertility: an unmatched case-control study in kigali, rwanda. | secondary infertility is a common, preventable but neglected reproductive health problem in resource-poor countries. this study examines the association of past sexually transmitted infections (stis) including hiv, bacterial vaginosis (bv) and factors in the obstetric history with secondary infertility and their relative contributions to secondary infertility. | 2011 | 21702916 |