Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| acute exacerbations in chinese patients with chronic hepatitis b virus (hbv) infection. incidence, predisposing factors and etiology. | three hundred and eighty-six chinese patients (262 men and 124 women), age 5-74 years, with chronic hepatitis b virus (hbv) infection were prospectively followed for 1-5 years to determine the incidence, predisposing factors and etiology of acute exacerbations that occurred during the course of chronic hbv infection. group i consisted of 334 patients with serum alanine aminotransferase (alt) levels below 200 iu/l at presentation. of these, 29 (8.7%) patients developed 32 episodes of acute exacer ... | 1990 | 2307827 |
| high prevalence of hepatitis b surface antigenaemia in nephrotic syndrome in hong kong. | of 61 boys and girls with relapsing or steroid-resistant nephrotic syndrome admitted for renal biopsy, 22 had persistent hepatitis b virus surface antigenaemia despite normal liver function and an absence of previous transfusion. the prevalence of hepatitis b virus surface antigenaemia amongst nephrotic patients is significantly higher than that of the general population. membranous nephropathy remains the commonest glomerulopathy associated with hepatitis b virus antigenaemia, and boys predomin ... | 1989 | 2471444 |
| synergism of chronic alcoholism and hepatitis b infection in liver disease. | one hundred and fifty-seven patients with alcoholic liver disease were studied. hepatitis b surface antigen (hbsag) was positive in 20.4% of the patients. those who were positive for the hbsag presented at an earlier age, had a lower albumin level, a higher globulin level, a more prolonged prothrombin time, were more likely to have features of cirrhosis in the liver biopsy, and were probably more likely to suffer from hepatic encephalopathy in the follow-up compared with those negative for hbsag ... | 1989 | 2490936 |
| comparison of two plasma-derived hepatitis b vaccines: long-term report of a prospective, randomized trial. | subjects at high risks for hepatitis b virus (hbv) infection were allocated randomly (n = 591) to receive one of the two plasma-derived hepatitis b vaccines produced by the institut pasteur production, paris (hevac b) or the green cross corporation, osaka (gcc vac). there are differences in the production of these two vaccines, with an added step of heat inactivation and longer formaldehyde treatment for the gcc vac. three doses of vaccines were given at 0, 1, and 5 months for both vaccines. ant ... | 1989 | 2535239 |
| the reliability of personal and family medical histories in the identification of hepatitis b carriers. | blood specimens were obtained from 300 patients and were tested for the five hepatitis b virus (hbv) serum markers: hbsag, hbeag, anti-hbs, anti-hbe and anti-hbc. medical histories were checked to determine any previous experience of hbv infection in the patients or their families. serum markers showed that 54.3% of the group had evidence of earlier hbv infection, 10% were hbsag carriers, and 3% were hbeag-positive. the patients' own histories correctly identified carriers in 23.1% of those givi ... | 1989 | 2717151 |
| factors determining the development of hepatocellular carcinoma in hepatitis b surface antigen carriers. a comparison between families with clusters and solitary cases. | this article documents five families with clusters of hepatocellular carcinoma (hcc), including one in which three successive generations were involved. all the 12 patients in these five families and 96.3% of the patients in 54 families with solitary cases of hcc seen during the same period were hepatitis b surface antigen (hbsag)-positive. the prevalence of hbsag in families with clusters and solitary cases of hcc was compared. the clustering of hcc in the five families reported could not be ac ... | 1988 | 2830957 |
| strong association between iga nephropathy and hepatitis b surface antigenemia in endemic areas. | the frequency of hepatitis b surface antigen (hbsag) was studied in the sera of 122 patients with primary iga nephropathy. hepatitis b surface (hbs) antigenemia was detected in 21 patients (17.2%) and this was significantly higher than the prevalence of hbsag carrier in the general population (p less than 0.01). these patients had no clinical or laboratory findings to suggest acute or chronic liver diseases. two glomerulopathic entities: mesangial proliferative glomerulonephritis with predominan ... | 1988 | 3293854 |
| the clinicopathological characteristics of iga nephropathy in hong kong. | the clinicopathologic data of 237 chinese patients with iga nephropathy from hong kong are reviewed in an attempt to identify the features pertinent to chinese patients. although the nephropathy is commonest in the 26-35 year age group, 11% of the iga nephritic patients were children below 16 years. the male predilection reported in caucasian populations is not observed and the male:female ratio is 0.94 in our series. the commonest renal manifestation is microscopic hematuria (25%) and 19% of th ... | 1988 | 3374969 |
| a longitudinal follow-up of asymptomatic hepatitis b surface antigen-positive chinese children. | fifty-one asymptomatic chinese hepatitis b surface antigen (hbsag) carrier children (34 boys, 17 girls), age 1 to 15 years (median: 10 years), were prospectively followed for up to 4 years (median: 30 months) to determine the natural evolution of clinical, biochemical and virological features during the early phase of chronic hepatitis b virus infection. hepatomegaly was the only abnormal finding on examination, being present in five children initially and four at follow-up. serum alt levels wer ... | 1988 | 3417235 |
| pattern of glomerulonephritis in hong kong. | a retrospective analysis of all renal biopsies (961) performed in two regional hospitals in hong kong during 1977-1985 revealed that iga nephropathy was the most frequently encountered glomerulopathy. lipoid nephrosis (minimal change nephrotic syndrome) remained the commonest cause of nephrotic syndrome in children. the frequencies of mesangiocapillary glomerulonephritis, focal glomerulosclerosis, and idiopathic membranous nephropathy were lower than in other populations. membranous nephropathy ... | 1987 | 3431912 |
| spontaneous hepatitis b e antigen to antibody seroconversion and reversion in chinese patients with chronic hepatitis b virus infection. | five hundred twelve (373 men, 139 women) patients, aged 1-75 yr, with chronic hepatitis b virus infection seen during a 5-yr period were analyzed. of these, 43.8% were hepatitis b e antigen (hbeag)-positive, 49.2% were positive for hepatitis b e antibody, and 7% were negative for both hbeag and hepatitis b e antibody at presentation. the cumulative probability of clearing hbeag at the end of the first, second, and third years was 17%, 30%, and 34%, respectively. the probability of clearing hbeag ... | 1987 | 3569757 |
| hepatitis b virus infection in chinese families in hong kong. | between january 1983 and july 1984, 731 family members of 240 hepatitis b surface antigen (hbsag) carriers were screened for hepatitis b virus markers. the percentage of those who were positive for hbsag was 28.3 and that for antibody to hepatitis b surface antigen/antibody to hepatitis b core antigen was 43.1. the carrier rate was higher among siblings (53%) and offspring (50.5%) of female carriers, but similar to that of the age-matched general population for spouses (10.8%). maternal transmis ... | 1987 | 3618581 |
| hepatocellular carcinoma in chinese males and females. possible causes for the male predominance. | the male-female ratio in 186 hepatocellular carcinoma (hcc) chinese patients was 5:1. the clinical presentation, biochemical parameters, and histologic findings were the same in both sexes except for a higher proportion of underlying cirrhosis (p = 0.02), and spider naevi (p = 0.04) in the men. there were also more smokers and alcohol drinkers among the men. over 75% of both sexes were positive for the hepatitis b surface antigen. the possible contributory factors to the predominance of males to ... | 1987 | 3038298 |
| placebo-controlled trial of recombinant alpha 2-interferon in chinese hbsag-carrier children. | 24 chinese children aged 1.5-5 years and positive for hepatitis b surface antigen (hbsag), hepatitis b e antigen (hbeag), hepatitis b virus dna polymerase (hbv dnap), and hbv dna on at least three occasions in the 6 months before the trial were randomised to receive either vitamin b complex or intramuscular recombinant alpha 2-interferon (r-ifn) ('roferon') 10 x 10(6) iu/m2 thrice weekly for 12 weeks. in all 12 subjects receiving r-ifn, hbv dnap and hbv dna levels fell during the course of r-ifn ... | 1987 | 2889081 |
| interferon therapy of chronic hepatitis b virus infection in chinese. | hepatitis b virus (hbv) infection is prevalent in chinese populations. 40.4% of 383 chinese hbv carriers studied were hbeag-positive. the annual rate of spontaneous clearance of hbeag was 11%. twenty-six patients with hbsag- and hbeag- and hbeag-positive non-malignant chronic liver disease randomised to receive recombinant alpha-2 interferon or no treatment have been followed for 6 months or longer. seven of the 20 treated patients cleared hbeag during or shortly after treatment but this was sus ... | 1986 | 3036936 |
| coxsackie-b-virus-specific igm responses in children with insulin-dependent (juvenile-onset; type i) diabetes mellitus. | coxsackie b1-6 virus igm responses were detected by an enzyme-linked immunosorbent assay (elisa) in 11 of 28 (39%) children aged 3-14 years in whom insulin-dependent (juvenile onset; type i) diabetes mellitus (iddm) developed in 1982. 5 patients had a homotypic response to coxsackie b4 and 1 had a homotypic response to b5. a serum sample had been obtained from each patient 2 to 16 weeks after onset of iddm symptoms. islet-cell cytoplasmic antibodies (igg) and complement fixing islet cell antibod ... | 1983 | 6134178 |
| hepatitis b virus and cigarette smoking: risk factors for hepatocellular carcinoma in hong kong. | one hundred seven chinese patients with primary hepatocellular carcinoma (phc) were compared with 107 hospital controls for the presence of hepatitis b surface antigen and smoking, drinking, and dietary habits. eighty-two % of phc cases were hepatitis b surface antigen positive compared to 18% of controls (relative risk, 21.3; 95% confidence limits, 10.1 and 45.9). prior history of jaundice was significantly related to phc, independent of hepatitis b surface antigen status. there was a significa ... | 1982 | 6291750 |
| liver cell dysplasia in association with hepatocellular carcinoma, cirrhosis and hepatitis b surface antigen in hong kong. | liver-cell dysplasia was identified in 60% of 558 cases of cirrhosis with and without hepatocellular carcinoma (hcc) in chinese coming to necropsy in hong kong from 1963 to 1978. a significant correlation was found between liver-cell dysplasia and the identification of hepatitis b surface antigen (hbsag) in the livers, suggesting that dysplasia may be casually related to hepatitis b virus (hbv). applying bayes' theorem to our series of male deaths, we calculated that for chinese male non-cirrhot ... | 1981 | 6273339 |
| hbv markers in chinese in hong kong. | a study was carried out on 779 hospital patients in the orthopaedic and paediatric unit of queen mary hospital, hong kong. patients who had no clinical evidence of liver disease, previous history of transfusion with blood or blood products and no major surgery in the past were entered into the study. markers of previous exposure to hepatitis b virus (hbv) were hbsag, anti-hbc and anti-hbs (radioimmunoassay) were done. the results showed that (a) chinese living in hong kong are exposed to hbv inf ... | 1980 | 7425525 |
| hepatitis b surface antigen, hepatocellular carcinoma and cirrhosis in hong kong: a necropsy study: 1963-1976. | hepatitis b surface antigen (hbsag) was stained in liver tissue in 71% of 496 cases of cirrhosis with and without hepatocellular carcinoma (hcc) in chinese coming to necropsy in hong kong from 1963-1976. male cases numbered 417; hbsag was positive in 83% of those in which hcc was combined with cirrhosis and in 62% of those with cirrhosis alone. of 39 additional male cases of hcc without cirrhosis, 38% were hbsag+. similar proportions were recorded in the famale cases. this progression suggests a ... | 1980 | 6252929 |
| antibody to hepatitis-b core antigen in patients with primary hepatic carcinoma. | antibody to hepatitis-b core antigen (anti-hbc) was assayed in the serum of patients with primary hepatic carcinoma (p.h.c.) and controls from hong kong, west africa, and the united states. in each region the prevalence of anti-hbc was higher in p.h.c. patients than in controls, ranging from 70 to 95% in the patients and from 20 to 68% in the controls from asia and africa; 24% of p.h.c. patients and 4% of controls from the u.s. had anti-hbc. these data support the hypothesis that chronic infec ... | 1975 | 49648 |
| antigenic variants of influenza b virus. | from 1967 to 1971 little antigenic variation was detected in the prevalent influenza b viruses but in december 1972 a new antigenic variant of influenza b was isolated in hong kong from sporadic cases of influenza. the new variant, b/hong kong/5/72, possessed a haemagglutinin antigen which showed considerable antigenic differences from that of former influenza b strains while its neuraminidase antigen was closely related to that of the earlier, 1967-71, isolates. the b/hong kong/5/72 variant bec ... | 1973 | 4201694 |