Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| long-term trends in pm2.5 mass and particle number concentrations in urban air: the impacts of mitigation measures and extreme events due to changing climates. | urbanisation and industrialisation led to the increase of ambient particulate matter (pm) concentration. while subsequent regulations may have resulted in the decrease of some pm matrices, the simultaneous changes in climate affecting local meteorological conditions could also have played a role. to gain an insight into this complex matter, this study investigated the long-term trends of two important matrices, the particle mass (pm2.5) and particle number concentrations (pnc), and the factors t ... | 2020 | 32268234 |
| maintaining pulpal vitality: cost-effectiveness analysis on carious tissue removal and direct pulp capping. | when managing deep carious lesions, dentists can maintain pulp vitality via (1) avoiding pulp exposure and complications by performing selective (se) instead of non-selective (ns) carious tissue removal, and/or (2) treat exposed pulps by direct capping with mineral-trioxide-aggregate (mta) instead of calcium hydroxide (ch). we assessed the cost-effectiveness of se vs. ns combined with direct pulp capping using mta vs. ch. | 2020 | 32259533 |
| quality of life in patients with morphea: a cross-sectional study and a review of the current literature. | the aim of the study was to evaluate qol in patients suffering from morphea. material and methods. sixty-five patients with morphea were recruited into this cross-sectional, prospective parallel study. qol among adult patients was assessed with the dermatology life quality index (dlqi) and euro-qol-5d questionnaire; patients aged <17 years used the children's dermatology life quality index (cdlqi). the severity of morphea was assessed using the localized scleroderma cutaneous assessment tool. th ... | 2020 | 32258158 |
| cost-effectiveness and cost-benefit of cervical cancer screening with liquid based cytology compared with conventional cytology in germany. | to assess the health economic impact of cervical screening with liquid based cytology (lbc) compared with conventional cytology (cc) in germany. | 2020 | 32256090 |
| euro-musculus/usprm global report on musculoskeletal ultrasound publications. | the developments in technology have improved access to the use of musculoskeletal ultrasound (msus) in different clinical settings. accordingly, msus has been applied to a wide range of musculoskeletal problems including inflammatory and degenerative diseases, sport injuries, and regional pain syndromes both for clinical practice and research. in this report, the authors aimed to globally examine the publications on msus among different specialties, countries, and topics. sixteen reviewers under ... | 2020 | 32251112 |
| cost-effectiveness of 12 weeks of supervised treatment compared to written advice in patients with knee osteoarthritis: a secondary analysis of the 2-year outcome from a randomized trial. | to assess the 24-month cost-effectiveness of supervised treatment compared to written advice in knee osteoarthritis (oa). | 2020 | 32243994 |
| cost-effectiveness and quality of life analysis of laparoscopic and robotic distal pancreatectomy: a propensity score-matched study. | this study analyzed the quality of life (qol) and cost-effectiveness of laparoscopic (ldp) versus robotic distal pancreatectomy (rdp). | 2020 | 32240383 |
| cost-effectiveness analysis of patiromer in combination with renin-angiotensin-aldosterone system inhibitors for chronic kidney disease in sweden. | patients with chronic kidney disease (ckd) are commonly treated with renin-angiotensin-aldosterone system inhibitors (raasi) in order to delay progression of renal disease. however, research has shown that raasi in ckd patients increases hyperkalaemia (hk) prevalence, which leads to raasi discontinuation or dose reduction with the loss of benefits on the kidney. patiromer is a novel therapy for hk treatment and may enable patients to remain on their raasi regimen. this study aimed to assess the ... | 2020 | 32239480 |
| favorable incremental cost-effectiveness ratio for lung cancer screening in italy. | lung cancer detection by low-dose computed tomographic screening reduces mortality. however, it is essential to assess cost-effectiveness. we present a cost-effectiveness analysis of screening in italians at high risk of lung cancer, from the point of view of the italian tax-payer. | 2020 | 32234647 |
| memory of decisions: relationship between decline of autobiographical memory and temporal discounting in alzheimer's disease. | temporal discounting refers to the tendency to attribute higher value to a reward received early than to one received later. we evaluated this tendency in patients with alzheimer's disease. we also evaluated whether temporal discounting is associated with decline in autobiographical memory (i.e., the ability to remember past personal experiences), with executive dysfunction, and/or with general cognitive decline. we invited patients with ad and control participants to answer binary questions inv ... | 2020 | 32223584 |
| prospective qualitative multidimensional assessment of the postoperative rhinoplasty experience. | background: understanding the multidimensional postoperative patient experience after rhinoplasty is critical for preoperative counseling and postoperative management. methods: a prospective clinical study was conducted from june to december 2019 for 60 patients undergoing cosmetic and/or functional rhinoplasty by two facial plastic surgeons. all patients were administered the brief pain inventory, a clinically validated pain instrument, including multiple quality of life (qol) domains, survey a ... | 2020 | 32223570 |
| scenario simulation of the eu carbon price and its enlightenment to china. | through exploring price characteristics of carbon futures products in eu et, this paper aims to provide china's policy makers with meaningful materials and references for understanding how a carbon trading market can be established and well regulated. based on the dataset comprising of multiple sources including euro stoxx600 index, coal and crude oil prices, natural gas prices and european clean energy company stock prices, etc., this paper uses bp neural network model to simulate the long-term ... | 2020 | 32222500 |
| how do drivers overtake pedestrians? evidence from field test and naturalistic driving data. | for pedestrians, the risk of dying in a traffic accident is highest on rural roads, which are often characterized by a lack of sidewalks and high traffic speed. in fact, hitting the pedestrian during an overtaking attempt is a common crash scenario. to develop active safety systems that avoid such crashes, it is necessary to understand and model driver behavior during the overtaking maneuvers, so that system interventions are acceptable because they happen outside drivers' comfort zone. previous ... | 2020 | 32203729 |
| associations of neural processing of reward with posttraumatic stress disorder and secondary psychotic symptoms in trauma-affected refugees. | background: psychological traumatic experiences can lead to posttraumatic stress disorder (ptsd). secondary psychotic symptoms are not common but may occur. objectives: since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in ptsd. methods: a total of 70 male refugees: 18 ptsd patients with no secondary psychotic symptoms (ptsd-nsp), 21 ... | 2020 | 32194922 |
| transanal drainage tube: alternative option to defunctioning stoma in rectal cancer surgery? | anastomotic leakage (al) remains the most dreaded complication after rectal cancer surgery. the aim of this study was to evaluate the role of transanal drainage tube in reducing the incidence, severity and hospital costs respect to defunctioning stoma (ds). | 2020 | 32190774 |
| authors' correction for euro surveill. 2020;25(9). | 2020 | 32183936 | |
| a sustainable approach to the metabolic syndrome in children and its economic burden. | the prevalence of obesity continues to grow, resulting in metabolic syndrome and increasing economic burden for health systems. the objectives were to measure the ability of the nim-mets test, previously used in the adults, for the early and sustainable detection of the metabolic syndrome (mets) in children and adolescents. moreover, to determine the economic burden of the children with mets. furthermore, finally, to use and implement the nim-mets test, via a self-created online software, as a n ... | 2020 | 32183278 |
| incidence and costs of hospitalized adult influenza patients in the netherlands: a retrospective observational study. | influenza virus infections cause a high disease and economic burden during seasonal epidemics. however, there is still a need for reliable disease burden estimates to provide a more detailed picture of the impact of influenza. therefore, the objectives of this study is to estimate the incidence of hospitalisation for influenza virus infection and associated hospitalisation costs in adult patients in the netherlands during two consecutive influenza seasons. | 2020 | 32180069 |
| optimizing organ donation: expert opinion from austria, germany, spain and the u.k. | background organ donation-rates using deceased donors and organizational approaches to organ donation differ drastically between countries at a similar level of health care as measured by the euro health consumer index (ehci). material and methods expert opinions from intensive care nurses, physicians, transplant coordinators and transplant surgeons from austria, germany, spain, and the u.k. were obtained in semi-structured interviews followed by qualitative content analysis. results were report ... | 2020 | 32179731 |
| health-related quality of life and associated factors among cervical cancer patients at tikur anbessa specialized hospital, addis ababa, ethiopia. | cancer of the cervix is the most frequent cancer among women in ethiopia. the disease burden and its treatment adversely affects patients' health-related quality of life (hrqol). we aimed to investigate the hrqol and its predictors among cervical cancer patients in ethiopia. | 2020 | 32178681 |
| confirmations, advances and recommendations for the daily care of schizophrenia based on the french national face-sz cohort. | the national fondamental centers of expertise (face) for schizophrenia (sz) have been created to shorten the gap between research and clinical practice. | 2020 | 32173456 |
| the cost of potentially inappropriate medications in nursing homes in west occitanie. | as of 2019, people older than 65 years represent 20% of the french population. despite several guidelines suggesting to avoid potentially inappropriate medication (pim) use in elderly, the prevalence of their prescription remains high (25%). furthermore, pim could lead to preventable adverse drug reactions (adrs). the main objective of this study was to determine the direct cost of pim in older persons living in residential care homes for the elderly (nursing homes). a secondary objective was to ... | 2020 | 32168740 |
| a methodological framework for drug development in rare diseases. the cresim program: epilogue and perspectives. | based on the 'european child-rare-euro-simulation' (cresim) project, this article proposes a generalizable strategy utilizing datasets analysis in combination with modeling and simulation, in order to optimize the clinical drug development applied in the field of rare diseases. the global process includes: (i) the simulation of a realistic virtual population of patients (modeled from a real dataset of patients), (ii) the modeling of disease pathophysiological components and of pharmacokinetic-ph ... | 2020 | 32156422 |
| non-hodgkin lymphoma after liver and kidney transplantation in children. experience from one center. | post-transplantation lymphoproliferative disorder (ptld) is a complication of organ transplantation and a life-threatening condition. children who underwent organ transplantation are at risk of developing lymphoproliferative disorders and, among them, non-hodgkin lymphoma (nhl) is the most serious. | 2020 | 32154678 |
| laparoscopic vs. open pancreaticoduodenectomy: a comparative study in elderly people. | the purpose of the study is to evaluate whether laparoscopic pancreatoduodenectomy (lpd) is safe and feasible for elderly patients. from december 2015 to january 2019, 142 lpd surgeries and 93 opd surgeries were performed by the same surgeon in the third affiliated hospital of soochow university. after applying the inclusion and exclusion criteria, we retrospectively collected the date of three defined groups: lpd aged < 70 years (group i, 84 patients), lpd aged ≥ 70 years (group ii, 56 patients ... | 2020 | 32152962 |
| delayed negative effects of prosocial spending on happiness. | does prosocial behavior promote happiness? we test this longstanding hypothesis in a behavioral experiment that extends the scope of previous research. in our saving a life paradigm, every participant either saved one human life in expectation by triggering a targeted donation of 350 euros or received an amount of 100 euros. using a choice paradigm between two binary lotteries with different chances of saving a life, we observed subjects' intentions at the same time as creating random variation ... | 2020 | 32152104 |
| formal social participation protects physical health through enhanced mental health: a longitudinal mediation analysis using three consecutive waves of the survey of health, ageing and retirement in europe (share). | previous studies have shown that formal social participation may reduce the risk of developing chronic conditions. yet, the underlying mechanisms are largely unknown. in this study, we assessed the potential mediating roles of quality of life and depressive symptoms using longitudinal data. | 2020 | 32151885 |
| cost-effectiveness of annual screening for tuberculosis among italian healthcare workers: a retrospective study. | in the past few years, healthcare workers (hcws) have been considered at higher risk for tuberculosis (tb) infection than the general population. on the other hand, recent studies have reported a low conversion rate among these workers. recently, the center for disease control (cdc) updated its recommendations, suggesting that an annual screening should not be performed in the absence of a documented exposure but only in workers with high-risk duties or with job tasks in settings at high risk of ... | 2020 | 32150923 |
| economic evaluation of individualized nutritional support in medical inpatients: secondary analysis of the effort trial. | existing guidelines support the importance of nutritional interventions for medical inpatients at malnutrition risk to alleviate the impact of malnutrition on outcomes. while recent studies have reported positive effects of nutritional support on health outcomes, limited evidence exists on whether in-hospital nutritional support also results in economic advantages. we report the results of the economic evaluation of effort-a pragmatic, investigator-initiated, open-label, multicenter trial. | 2020 | 32147200 |
| cost-effectiveness analyses of interventions to improve osteoporosis care in france. | osteoporosis (op) is responsible for an important economic burden, but op care is far from meeting therapeutic guidelines. some interventions were effective to improve op management. our objective was to evaluate the cost-effectiveness of these interventions. structural interventions and interventions consisting in sending educational material were dominant strategies. | 2020 | 32146536 |
| detection of cocaine on euro banknotes; development of a practical approach for the interpretation of suspect cases. | the presence of traces of narcotics, particularly cocaine, on banknotes in circulation is a known and widespread fact in all countries. while linked to consumption and trafficking (primary contamination), their spread is due to direct contact with other banknotes during machine counting and cash financial transactions. the mere detection of traces of cocaine on a sample of banknotes is therefore not sufficient evidence to establish the banknote's illegal origin. increasing levels of contaminatio ... | 2020 | 32146301 |
| treatment of hcv infection with direct-acting antiviral agents. real life experiences from the euro-asian region. | hepatitis c virus (hcv) infection is a common disease that causes liver cirrhosis, hepatocellular carcinoma, and extra hepatic manifestations with high mortality and morbidity rates. this study aimed to present real-life experiences and results of treatment of hcv infection with direct-acting antiviral agents (daas) from the euro-asian region, including turkey and azerbaijan. | 2020 | 32141824 |
| return on investment: a practical calculation tool to convince your institution. | the significant investments necessary to integrate a new technology or service often create a financial barrier. to convince a hospital board to invest, it is important to demonstrate a return on investment (roi). as many pharmacists are not used to estimating an roi, this short report proposes a simple methodology and a free practical tool to download. | 2020 | 32133138 |
| authors' correction for euro surveill. 2020;25(7). | 2020 | 32127128 | |
| health economic evaluation of implantable cardioverter defibrillators in hypertrophic cardiomyopathy in adults. | hypertrophic cardiomyopathy is a heterogeneous disease in which an implantable cardioverter defibrillator (icd) effectively prevents sudden cardiac death in at-risk individuals. nevertheless, the cost-effectiveness of icds in this specific patient group has not been evaluated. | 2020 | 32122698 |
| the role of cohesion policy funds in decreasing the health gaps measured by the euro-healthy population health index. | social, economic, and environmental differences across the european union significantly affect opportunities to move forward in achieving greater equity in health. cohesion policy (cp) funds can contribute positively through investments in the main determinants of health. the aim of this study is to analyze to what extent the planned investments for 2014-2020 are addressing the regional health gaps, in light of the population health index (phi), a multidimensional measure developed by the euro-h ... | 2020 | 32121335 |
| new perspectives by imaging modalities for an old illness: rheumatic mitral stenosis. | mitral stenosis (ms) is a progressive and devastating disease and most often occurs among young women. given its considerable prevalence in mediterranean and eastern european countries according to the euro heart survey, new imaging modalities are warranted to improve the management of patients with this condition. a wide spectrum of abnormalities occurs involving all parts of this complex structure and causing different grades of ms and/or regurgitation as a consequence of rheumatic affection. ... | 2020 | 32120357 |
| economic impact of a bluetongue serotype 8 epidemic in germany. | background and objectives: germany was affected by bluetongue virus serotype 8 (btv-8) from 2006 to 2009 and recorded new cases since december 2018. we assessed the economic impact of the epidemic from the first cases in 2006 until 2018. direct costs include production losses, animal deaths, and veterinary treatment. indirect costs include surveillance, additional measures for animal export, disease control (preventive vaccination and treatment with insecticides), vector monitoring, and administ ... | 2020 | 32118078 |
| the impact of the applied technology on health and productivity in manual "picker-to-part" systems. | manual "picker-to-part" order picking takes place in a labour-intensive and time-consuming working environment where humans are the central actors and co-determine the effectiveness and efficiency of the process. throughout europe, work-related musculoskeletal disorders affect millions of workers, especially in the logistics sector, and cost employers billions of euros. | 2020 | 32116272 |
| twenty-year trends in the prescription costs of type 2 diabetes: real world data and empirical analysis in greece. | to estimate and compare the prescription costs for the management of patients with diabetes over a period of 20 years in greece, based on real world data. | 2020 | 32112790 |
| particulate emissions from gasoline direct injection engines: a review of how current emission regulations are being met by automobile manufacturers. | gasoline direct injection (gdi), which is one of the fuel injection technologies extensively used in internal combustion engines, is a viable alternative for port fuel injection technology in premium gasoline (petrol)-run vehicles; furthermore, it provides a better fuel economy, higher thermal efficiency, and greater power output. however, the particulate emissions ejected from modern gdi engines are an environmental and health hazard. as a result, stringent emission legislations are imposed on ... | 2020 | 32109813 |
| the nature stroke study; nastru: a randomized controlled trial of nature-based post-stroke fatigue rehabilitation. | to determine whether nature-based rehabilitation, as an add-on to standard care, has a long-term influence on post-stroke fatigue, perceived value of everyday occupations, disability, health-related quality of life, anxiety, and depression at follow-up 8 and 14 months after randomization. | 2020 | 32105334 |
| cost of early-stage mycosis fungoides treatments in spain. | to identify the most common therapeutic options for the treatment of early-stage mycosis fungoides in spain, quantify their associated healthcare resource use and costs. | 2020 | 32104021 |
| the role of pension contributions in explaining inequalities in depressive symptoms. results from share. | aims: research has established solid evidence that socioeconomic position impacts health. it is, however, still debated to what extent characteristics of entire employment histories are associated with health inequalities later on. this study investigates associations between contributing to pension schemes throughout entire employment histories and depressive symptoms in older men and women. methods: we use retrospective life history data from the survey of health, ageing and retirement in euro ... | 2020 | 32103706 |
| author's correction for euro surveill. 2020;25(4). | 2020 | 32098643 | |
| international evidence-based guidelines on point of care ultrasound (pocus) for critically ill neonates and children issued by the pocus working group of the european society of paediatric and neonatal intensive care (espnic). | point-of-care ultrasound (pocus) is nowadays an essential tool in critical care. its role seems more important in neonates and children where other monitoring techniques may be unavailable. pocus working group of the european society of paediatric and neonatal intensive care (espnic) aimed to provide evidence-based clinical guidelines for the use of pocus in critically ill neonates and children. | 2020 | 32093763 |
| atmiyata, a community-led intervention to address common mental disorders: study protocol for a stepped wedge cluster randomized controlled trial in rural gujarat, india. | while lay-health worker models for mental health care have proven to be effective in controlled trials, there is limited evidence on the effectiveness and scalability of these models in rural communities in low- and middle-income countries (lmics). atmiyata is a rural community-led intervention using local community volunteers, called champions, to identify and provide a package of community-based interventions for mental health, including evidence-based counseling for persons with common mental ... | 2020 | 32085716 |
| gender differences in health-related quality of life in people with severe mental illness. | the purpose was to analyze socioeconomic and clinical factors of psychosocial functioning and self-perception in relation to health-related quality of life (hrqol) in people with severe mental health illness (smi) by gender. | 2020 | 32084212 |
| an assessment of how distance and diesel oxidation catalyst will impact thermal decomposition behaviors of particles. | decomposition mass loss and pyrolysis products analyses of particles sampled at various locations along the tailpipe of a euro-iv diesel engine were performed using a thermogravimetry in conjunction with fourier transformation infrared spectrometry-mass spectrum. diesel particles were collected at the same location with and without diesel oxidation catalyst (doc) mounted on the test engine separately. the three poles in thermal gravity-differential thermal gravity images suggested that the decom ... | 2020 | 32081312 |
| safety and efficacy of jujadokseo-hwan for memory deficit (amnesia) in mild neurocognitive disorder: a protocol for randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical trial. | mild neurocognitive disorder (mncd) is one of the degenerative diseases that results in memory deficit, and can progress to dementia. the effectiveness of drug therapy for mncd is still debatable, but treatment of this disease has important implications for postponing or preventing dementia. jujadokseo-hwan (jdh) is a traditional herbal medicine formulation that exhibits improvement in cognitive abilities and neuroprotective effects. in this study, we will evaluate the safety and efficacy of jdh ... | 2020 | 32080123 |
| nosocomial infections in patients hospitalized with respiratory syncytial virus: a practice review. | viral testing is not always recommended in children with bronchiolitis due to doubts concerning its prognostic use. in this retrospective study, we investigated how the rsv testing would influence the frequency of nosocomial infections (ni). the files of 305 children, hospitalized due to the respiratory syncytial virus (rsv) infection in the period 2010-2014, were reviewed in the study. we found ten cases of ni. the rsv preventive measures did not vary in the consecutive years investigated, but ... | 2020 | 32078148 |
| cost-utility analysis of learning and coping versus standard education in cardiac rehabilitation: a randomised controlled trial with 3 years of follow-up. | to enhance adherence to cardiac rehabilitation (cr), a patient education programme called 'learning and coping' (lc-programme) was implemented in three hospitals in denmark. the aim of this study was to investigate the cost-utility of the lc-programme compared with the standard cr-programme. | 2020 | 32076564 |
| analysing actual prices of medical products: a cross-sectional survey of dutch hospitals. | to assess whether there is a difference between the net prices of medical products used by dutch hospitals and, if there is, how this difference can be explained. | 2020 | 32075844 |
| economic evaluation of abobotulinumtoxina vs onabotulinumtoxina in real-life clinical management of cervical dystonia. | botulinum neurotoxins type a (bont-as) are commonly used treatments for cervical dystonia (cd). clinical trials have demonstrated the benefits of them in these patients, but data from real-life clinical practice as well as comparative data on the cost and outcome of different bont-a formulations are limited. the aim of this study was to compare abobotulinumtoxina (abobont-a) and onabotulinumtoxina (onabont-a) on their clinical outcomes and drug costs in real-life clinical practice. | 2020 | 32071728 |
| a systematic review on cost-effectiveness studies evaluating ovarian cancer early detection and prevention strategies. | ovarian cancer imposes a substantial health and economic burden. we systematically reviewed current health-economic evidence for ovarian cancer early detection or prevention strategies. accordingly, we searched relevant databases for cost-effectiveness studies evaluating ovarian cancer early detection or prevention strategies. study characteristics and results including quality-adjusted life years (qaly), and incremental cost-effectiveness ratios (icer) were summarized in standardized evidence t ... | 2020 | 32071120 |
| erratum for euro surveill. 2020;25(5). | 2020 | 32070469 | |
| assessment of health related quality of life and digestive symptoms in long-term, disease free survivors after esophagectomy. | the aim of this study was to investigate long-term hrqol and symptom evolution in disease free patients up to 20 years after esophagectomy. | 2020 | 32068555 |
| relationship between heatwave-induced forest die-off and climatic suitability in multiple tree species. | in recent decades, many forest die-off events have been reported in relation to climate-change-induced episodes, such as droughts and heat waves. to understand how these extreme climatic events induce forest die-off, it is important to find a tool to standardize the climatic conditions experienced by different populations during a specific climatic event, taking into account the historic climatic conditions of the site where these populations live (bioclimatic niche). in this study, we used esti ... | 2020 | 32064733 |
| climate variability in early expansions of homo sapiens in light of the new record of micromammals in misliya cave, israel. | in this study, we provide the first taphonomic and taxonomic descriptions of the micromammals from misliya cave, where recently a homo sapiens hemimaxilla has been reported. this finding significantly extends the time frame for the out-of-africa presence of anatomically modern humans. it also provides an opportunity to reassess variation in early modern human population responses to climate change in the levantine sequence. information on species ranking and diversity estimations (shannon functi ... | 2020 | 32062432 |
| evaluating the cost-consequence of a standardized strategy for the etiological diagnosis of uveitis (ulisse study). | to prospectively assess the cost-consequence of a standardized diagnostic strategy as to compared to an open one for the etiological diagnosis of uveitis. | 2020 | 32059021 |
| plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy. | several studies have now shown that chronic myeloid leukaemia (cml) patients in deep molecular remission may discontinue tyrosine kinase inhibitor (tki) treatment with a treatment free remission (tfr) rate of approximately 40-60 %. some factors influencing the possibility of tfr have been described but better tools are needed for individual prediction of long-term tfr. herein, two multiplex panels were utilised to analyse a total of 162 different plasma proteins from 56 patients included in the ... | 2020 | 32058176 |
| updated incidence and costs of hip fractures in elderly italian population. | we aimed at updating our previous researches about the burden of hip fractures in elderly italian population. | 2020 | 32056151 |
| advancing tools to promote health equity across european union regions: the euro-healthy project. | population health measurements are recognised as appropriate tools to support public health monitoring. yet, there is still a lack of tools that offer a basis for policy appraisal and for foreseeing impacts on health equity. in the context of persistent regional inequalities, it is critical to ascertain which regions are performing best, which factors might shape future health outcomes and where there is room for improvement. | 2020 | 32054540 |
| economic impact of industry-sponsored clinical trials of pharmaceutical products in austria. | aims: modern pharmaceutical product development is a long and complex process associated with significant investments by pharmaceutical companies. the innovative pharmaceutical industry accounts for the vast majority of expenditures in clinical trials of potential new pharmaceuticals and therefore generates economic activity within a country. the aim was to assess the far-reaching economic impact of industry-sponsored clinical-trials (iscts) of pharmaceutical products for the healthcare system a ... | 2020 | 32046538 |
| statistical modeling of the early-stage impact of a new traffic policy in milan, italy. | most urban areas of the po basin in the north of italy are persistently affected by poor air quality and difficulty in disposing of airborne pollutants. in this context, the municipality of milan started a multi-year progressive policy based on an extended limited traffic zone (area b). starting on 25 february 2019, the first phase partially restricted the circulation of some classes of highly polluting vehicles on the territory, in particular, euro 0 petrol vehicles and euro 0 to 3 diesel vehic ... | 2020 | 32046370 |
| whole genome sequencing results associated with minimum inhibitory concentrations of 14 anti-tuberculosis drugs among rifampicin-resistant isolates of mycobacterium tuberculosis from iran. | accurate and timely detection of drug resistance can minimize the risk of further resistance development and lead to effective treatment. the aim of this study was to determine the resistance to first/second-line anti-tuberculosis drugs in rifampicin/multidrug-resistant mycobacterium tuberculosis (rr/mdr-mtb) isolates. molecular epidemiology of strains was determined using whole genome sequencing (wgs)-based genotyping. a total of 35 rr/mdr-mtb isolates were subjected to drug susceptibility test ... | 2020 | 32046149 |
| [the cost of vaccination throughout life in spain]. | the evaluation of vaccination programmes using cost estimation is an essential tool for immunization policy. the aim of this study was to describe the cost of vaccination through-out life in spain, both in healthy and risk groups persons. | 2020 | 32041940 |
| cost-effectiveness of platelet-rich plasma for diabetic foot ulcer in spain. | this study evaluated the cost-effectiveness of platelet-rich plasma (prp) added to usual care versus usual care alone in elderly patients with chronic diabetic foot ulcer (dfu) from the spanish health care system perpective. a 6-state markov model with 3-month cycles was used to estimate costs and outcomes of wound healing and risk of recurrences, infections, and amputations over 5 years. three treatment strategies were compared: (a) usual care plus prp obtained with a commercial kit, (b) usual ... | 2020 | 32037919 |
| systematic analysis of button batteries', euro coins', and disk magnets' radiographic characteristics and the implications for the differential diagnosis of round radiopaque foreign bodies in the esophagus. | button battery (bb) ingestion can cause life-threatening complications such as esophageal perforation, and mediastinitis. chest radiography is the method of choice to diagnose bb ingestion. therefore, an adequate interpretation of x-ray imaging by physicians is mandatory. the study aimed to analyze relevant diagnostic aspects of bb x-ray imaging, and retrospective analysis of the imaging of radiopaque foreign bodies. | 2020 | 32032915 |
| quality of life of rural poor elderly in anhui, china. | this study is to explore the quality of life (qol) of the rural poor elderly in central china (anhui province) and the influencing factors.a multi-stage random sampling method was used to extract 3352 effective samples of the rural elderly in anhui, including 1206 poor and 2146 non-poor elderly subjects. euro qol 5-dimension questionnaire (eq-5d) was used for the measurement of qol. descriptive statistics and χ test were used to compare and analyze the sociodemographic characteristics and qol sc ... | 2020 | 32028437 |
| antibiotic use and resistance in belgium: the impact of two decades of multi-faceted campaigning. | objective: to present an overview of almost two decades of multi-faceted campaigning by the belgian antibiotic policy coordination committee (bapcoc) and partners, and its impact on public and prescribers' awareness, outpatient antibiotic use, its cost and antimicrobial resistance in belgium.methods: awareness of both public and prescribers was assessed through pre- and post-campaign interviews and surveys. outpatient antibiotic use was evaluated using national reimbursement data expressed in nu ... | 2020 | 32024450 |
| limited life cycle and cost assessment for the bioconversion of lignin-derived aromatics into adipic acid. | lignin is an abundant and heterogeneous waste byproduct of the cellulosic industry, which has the potential of being transformed into valuable biochemicals via microbial fermentation. in this study, we applied a fast-pyrolysis process using softwood lignin resulting in a two-phase bio-oil containing monomeric and oligomeric aromatics without syringol. we demonstrated that an additional hydrodeoxygenation step within the process leads to an enhanced thermochemical conversion of guaiacol into cate ... | 2020 | 32022244 |
| costs and cost drivers associated with non-small-cell lung cancer patients who received two or more lines of therapy in europe. | advanced non-small-cell lung cancer (ansclc; stage iiib/iv) presents a substantial clinical burden to society; reliable estimates of its economic burden are lacking. therefore, this study aimed to quantify real-world health care resource utilization (hcru) and costs of patients with squamous (sq) and non-sq (nsq) ansclc who received two or more lines of treatment (2l+) in europe, and to describe cost-predictors. | 2020 | 32021337 |
| are direct oral anticoagulants an economically attractive alternative to low molecular weight heparins in lung cancer associated venous thromboembolism management? | venous thromboembolism is highly prevalent in lung cancer patients. low molecular weight heparins are recommended for long term treatment of cancer associated venous thromboembolism. direct oral anticoagulants are however an interesting alternative as they are administered orally and don't require monitoring. there are currently studies comparing both their efficacy and tolerance for cancer patients and more and more guidelines suggest considering direct oral anticoagulants for cancer associated ... | 2020 | 32020515 |
| antimicrobial resistance in neisseria gonorrhoeae isolates from foreign-born population in the european gonococcal antimicrobial surveillance programme. | international spread has contributed substantially to the high prevalence of antimicrobial resistant (amr) neisseria gonorrhoeae infections worldwide. we compared the prevalence of amr gonococcal isolates among native persons to foreign-born (reporting country different from country of birth) persons, and describe the epidemiological and clinical characteristics of foreign-born patients and their associations to amr. | 2020 | 32019895 |
| social value of a set of proposals for the ideal approach of multiple sclerosis within the spanish national health system: a social return on investment study. | multiple sclerosis (ms) is a chronic inflammatory, demyelinating and neurodegenerative disease that in many cases produces disability, having a high impact in patients' lives, reducing significantly their quality of life. the aim of this study was to agree on a set of proposals to improve the current management of ms within the spanish national health system (snhs) and apply the social return on investment (sroi) method to measure the potential social impact these proposals would create. | 2020 | 32019531 |
| innovation technology in neurorehabilitation: introducing a hub and spoke model to avoid patient "migration" in sicily. | in the italian national health service, hospital planning has been influenced by two aspects: patients' freedom to choose their healthcare provider and the equal distribution of centers spread throughout country. unfortunately, while every italian region should be able to meet the health needs of its own inhabitants, consistent migration among regions exists, especially from the southern areas of the country, including sicily. as it has been demonstrated that a hub-and-spoke model (hsm) can prov ... | 2020 | 32017847 |
| aggressive local control with multisite stereotactic body radiation in metastatic ewing sarcoma: a literature review and case report. | ewing sarcoma (es) is an undifferentiated small round blue cell tumor most commonly originating in the bone of adolescents 10-20 years of age, although 30% are diagnosed in adults. the most important prognostic factor is the presence of metastatic disease. results of the euro-ewing 99 trial of es patients showed that local treatment of not only the primary, but also of the sites of metastatic disease should be considered to improve event-free survival. the use of stereotactic body radiotherapy ( ... | 2020 | 32014939 |
| notes on the new “recommendations for the treatment of dyslipidemia. influencing of lipids to reduce cardiovascular risk”. | new guidelines on dyslipidemia (dlp) related problems appear earlier than planned. primarily in view of the results of science and large clinical studies, but also with regard to the advent of biological therapy (pcsk9-i) in many euro-pean countries. also, the “conventional” hypolipidemic therapy is generified and therefore cheaper, more af-fordable. the recommendations are based, as the preceding ones, on the principle of estimating the overall cardiovascular risk. the innovated sco ... | 2020 | 32013517 |
| the social return on investment of a new approach to heart failure in the spanish national health system. | we aim to agree on a set of proposals to improve the current management of heart failure (hf) within the spanish national health system (snhs) and apply the social return on investment (sroi) method to measure the social impact that these proposals would generate. | 2020 | 31916416 |
| production of foot-and-mouth disease virus sat2 vp1 protein. | the seven serotypes of foot-and-mouth disease virus (fmdv) differ on the surface exposed regions on the vp1, 2 and 3 proteins. amongst the three, the vp1 protein has been produced the most for use in serotyping assays for some of the euro-asian serotypes. in this study the vp1 protein of the fmdv sat2/zim/7/83 was expressed in escherichia coli bl21 cells in luria broth and enpresso® b media in shake flasks. production was further developed and the vp1 protein was produced at 2.15 g l-1 in fed-ba ... | 2020 | 31912326 |
| spoligotyping and drug sensitivity of mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in the arsi zone of southeastern ethiopia. | tuberculosis (tb) is one of the leading causes of morbidity and mortality in different zones of ethiopia. this study was undertaken to identify the strains of mycobacterium tuberculosis and evaluate their drug sensitivity profiles in the arsi zone. a total of 111 isolates of m. tuberculosis from individuals with pulmonary tb were included and speciation and strain identification were performed using region of difference 9 and spoligotyping, respectively. the drug sensitivity patterns were assess ... | 2020 | 31908780 |
| routine pathology examination in the era of value-based healthcare: the case of haemorrhoids specimens. | routine pathologic examination of specimens is a common practice with ill-defined value. the present study is the first to investigate the incidence and cost of incidental microscopic lesions in both haemorrhoidectomy and stapled haemorrhoidopexy specimens. pathological reports of specimens obtained from haemorrhoidectomy and stapled haemorrhoidopexy procedures performed from january 2003 to may 2017 were analysed. specimens resulting from patients treated for any disease other than haemorrhoids ... | 2020 | 31907868 |
| socioeconomic status of patients in a swedish national self-management program for osteoarthritis compared with the general population-a descriptive observational study. | first-line treatment for hip and knee osteoarthritis (oa) including education and supervised exercises, delivered as a self-management program, is considered one of the mainstays in oa treatment. however, the socioeconomic profile of the population that utilizes first-line treatment for hip and knee oa is unclear. the aim of this study was to describe the socioeconomic status (ses) of a population referred to a self-management program for oa, in comparison with that of the general swedish popula ... | 2020 | 31906904 |
| offspring production among the relatives of istmo zapotec men and muxes. | male androphilia (i.e., sexual attraction toward adult males) is influenced by biological factors, reliably occurs across diverse cultures, and has persisted over evolutionary time despite the fact that it reduces reproduction. one possible solution to this evolutionary paradox is the sexually antagonistic gene hypothesis (sagh), which states that genes associated with male androphilia reduce reproduction when present in males but increase reproduction when present in their female relatives. the ... | 2020 | 31897830 |
| cost-effectiveness and budget impact of the microprocessor-controlled knee c-leg in transfemoral amputees with and without diabetes mellitus. | the safe use of a prosthesis in activities of daily living is key for transfemoral amputees. however, the number of falls varies significantly between different prosthetic device types. this study aims to compare medical and economic consequences of falls in transfemoral amputees who use the microprocessor-controlled knee joint c-leg with patients who use non-microprocessor-controlled (mechanical) knee joints (nmpk). the main objectives of the analysis are to investigate the cost-effectiveness a ... | 2020 | 31897813 |
| fear goliath or david? inferring competence from demeanor across cultures. | we examined cultural differences in people's lay theories of demeanor-how demeanor may be perceived as a straightforward and reliable reflection of reality (convergence theory) or as a deviating reflection of reality (divergence theory). across different domains of competition, euro-canadians perceived greater competence in an opponent with a competent demeanor, whereas chinese paradoxically perceived greater competence in an opponent with no signs of competence (studies 1-4b). the results, unex ... | 2020 | 31889473 |
| particulate emissions from l-category vehicles towards euro 5. | the current experimental study presents particulate emissions from 30 euro 1-4 l-category vehicles (i.e. 2-, 3- and 4-wheelers such as mopeds, motorcycles, quads and minicars, registered in europe between 2009 and 2016) tested on a chassis dynamometer. the objectives were to identify those sub-categories with high emissions, to assess whether the measures prescribed in the euro 5 legislation will effectively control particulate emissions and finally to investigate the need for additional measure ... | 2020 | 31887467 |
| corr insights®: which factors are associated with local control and survival of patients with localized pelvic ewing's sarcoma? a retrospective analysis of data from the euro-ewing99 trial. | 2020 | 31876550 | |
| obesity: a preventable, treatable, but relapsing disease. | in 2013, the american medical association recognized obesity as a disease, of growing scientific, social, and political interest. in 2016 in the united states, prevalence rates of preobesity and obesity exceeded 60%. in italy, these rates exceeded 40%. total costs related to excess weight reached 9.3% of the u.s. gross domestic product, whereas in italy the total annual cost of diabetes alone was estimated at 20.3 billion euros/y. the expansion of adipose tissue and visceral fat causes compressi ... | 2020 | 31864969 |
| inequalities in the distribution of childhood adversity from birth to 11 years. | exposure to early adversity carries long term harmful consequences for children's health and development. this study aims to 1) estimate the prevalence of childhood adversity for australian children from infancy to 10-11 years, and 2) document inequalities in the distribution of adversity according to socioeconomic position (sep), indigenous status, and ethnicity. | 2020 | 31841661 |
| the cost utility of pitolisant as narcolepsy treatment. | the cost-effectiveness of available pharmacological treatments for narcolepsy is largely unknown. available pharmacological treatments are associated with tolerability, abuse, and adherence issues. pitolisant is the first inverse agonist of the histamine h3 receptor to be prescribed for the treatment of narcolepsy with and without cataplexy. studies suggest that pitolisant is both as effective as previously introduced drugs and is associated with fewer adverse effects. the objective in this stud ... | 2020 | 31838740 |
| french icu's health care workers have a poor knowledge of the cost of the devices they use for patient care: a prospective multicentric study. | icu patient's care may require the use of onerous devices, which contributes to make this department one of the most expensive in the hospital. it seemed us relevant to assess healthcare workers' (hcws) knowledge of the cost of the devices daily used in icu. | 2020 | 31837599 |
| assessment of excess medical costs for persons with type 2 diabetes according to age groups: an analysis of german health insurance claims data. | this cross-sectional study used a large nationwide claims data set to assess the excess medical costs of people with type 2 diabetes according to age group in 2015. | 2020 | 31834643 |
| is there a clinical role for frozen section analysis during partial nephrectomy? a multicenter experience over 10 years. | frozen section analysis (fsa) is frequently performed during partial nephrectomy (pn). we investigate the utility of intraoperative fsa by evaluating its impact on final surgical margin (sm) status. | 2020 | 31833332 |
| priorities in research on foodborne parasites indicated by short-term scientific missions as part of cost action a european network for foodborne parasites (euro-fbp). | the european cooperation in science and technology (cost) is a funding organization for the creation of research networks. these networks support collaboration and networking among scientists across europe and thereby give impetus to research advancements and innovation. one of the most important mechanisms of cost actions are the short-term scientific missions (stsm), which are a funding mechanism that enables scientists, particularly those earlier in their careers, to visit an institution or l ... | 2020 | 31830462 |
| preclinical assessment of a new live attenuated mycobacterium tuberculosis beijing-based vaccine for tuberculosis. | tuberculosis still claims more lives than any other pathogen, and a vaccine better than bcg is urgently needed. one of the challenges for novel tb vaccines is to protect against all mycobacterium tuberculosis lineages, including the most virulent ones, such as the beijing lineage. here we developed a live attenuated m. tuberculosis mutant derived from gc1237, a beijing strain responsible for tuberculosis outbreaks in the canary islands. the mutant strain is inactivated both in the rv1503c gene, ... | 2020 | 31862194 |
| adpkd current management and ongoing trials. | among the diseases that require renal replacement therapy (rrt), adpkd is the fourth for incidence and prevalence. in italy, there are at least 32,000 patients affected by adpkd, of which about 2900 in dialysis. the pure costs of dialysis treatment for the italian national health service can be conservatively estimated at 87 million euros per year. even a modest slowdown in the evolution of the disease would obtain an important result in terms of reduction of health expenditure. in recent years, ... | 2020 | 31853789 |
| abobotulinumtoxina and rehabilitation vs rehabilitation alone in post-stroke spasticity: a cost-utility analysis. | to investigate costs and quality-adjusted life years of rehabilitation combined with abobotulinumtoxina (abobont-a) (rehab/abobont-a) vs rehabilitation alone (rehab) in post-stroke spasticity in italy. | 2020 | 31820010 |
| health economic evaluations of interventions to increase physical activity and decrease sedentary behavior at the workplace: a systematic review. | objective the workplace is an ideal setting to implement public health strategies, but economic justification for such interventions is needed. therefore, we performed a critical appraisal and synthesis of health economic evaluations (hee) of workplace interventions aiming to increase physical activity (pa) and/or decrease sedentary behavior (sb). methods a comprehensive search filter was developed using appropriate guidelines, such as the peer review of electronic search strategies (press) chec ... | 2020 | 31820003 |