Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| genetics of prostate cancer risk. | for decades, physicians and researchers have recognized that family history is a significant risk factor for prostate cancer. the identification of the genes responsible for inherited risk, however, proved difficult. with the sequencing of the human genome and the completion of the initial phases of the international hapmap project, the tools are available to scan the entire genome and find genetic markers for disease. since 2006, more than 30 inherited variants strongly associated with prostate ... | 2010 | 21105126 |
| beyond the genome: genomics research ten years after the human genome sequence. | a report on the meeting 'beyond the genome', boston, usa, 11-13 october 2010. | 2010 | 21122162 |
| pharmaceutical interventions for mitigating an influenza pandemic: modeling the risks and health-economic impacts. | model-based analyses built on burden-of-disease and cost-effectiveness theory predict that pharmaceutical interventions may efficiently mitigate both the epidemiologic and economic impact of an influenza pandemic. pharmaceutical interventions typically encompass the application of (pre)pandemic influenza vaccines, other vaccines (notably pneumococcal), antiviral treatments and other drug treatment (e.g., antibiotics to target potential complications of influenza). however, these models may be to ... | 2010 | 21133667 |
| effect modification of air pollution on urinary 8-hydroxy-2'-deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant snp interactions. | air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. one suggested pathway is that pollution causes oxidative stress. if so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure. | 2010 | 21138591 |
| infectious chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. | neutrophilic asthma is thought to be less responsive than eosinophilic asthma to anti-inflammatory therapies including corticosteroids. chlamydia pneumoniae has been implicated in asthma, possibly by induction of interleukin (il-8). we hypothesized that il-8 is increased in the bronchoalveolar lavage (bal) fluid from children with asthma and c. pneumoniae. | 2010 | 21155094 |
| outbreak of adenovirus type 4 infection in a long-term care facility for the elderly. | an outbreak of acute respiratory disease due to human adenovirus and a resulting increase in mortality occurred in a long-term care facility for the elderly. by use of viral culture and polymerase chain reaction, not a rapid antigen test, the virus was detected. human adenovirus infection can occur in elderly individuals, but detection by rapid antigen testing may be limited. | 2010 | 20509762 |
| cystic fibrosis newborn screening: using experience to optimize the screening algorithm. | newborn screening (nbs) for cystic fibrosis (cf) offers the opportunity for early diagnosis and improved outcomes in patients with cf and has been universally available in the state of massachusetts since 1999 using an immunoreactive trypsinogen (irt)-dna algorithm. ideally, cf nbs is incorporated as part of an integrated nbs system that allows for comprehensive and coordinated education, laboratory screening, clinical follow-up, and evaluation so that evidence-based data can be used to maximize ... | 2010 | 20521170 |
| plasma cystatin c and acute kidney injury after cardiopulmonary bypass. | little is known about the performance of plasma cystatin c (cysc) in patients undergoing cardiopulmonary bypass (cpb) and its utility in the early diagnosis of acute kidney injury (aki). in this post hoc analysis, the goal was to determine whether plasma cystatin c, measured 2 hours after the conclusion of cpb, is a reliable marker of aki. | 2010 | 20522534 |
| a qualitative study of the meaning of fatherhood among young urban fathers. | to explore the beliefs, attitudes, and needs young men have regarding their role as a father. | 2010 | 20525094 |
| changes in glycemic control from 1996 to 2006 among adults with type 2 diabetes: a longitudinal cohort study. | our objectives were to examine temporal changes in hba1c and lipid levels over a 10-year period and to identify predictors of metabolic control in a longitudinal patient cohort. | 2010 | 20534158 |
| the american red cross and local response to the 1918 influenza pandemic: a four-city case study. | the role of the american red cross in the u.s. response to the 1918-1919 influenza pandemic holds important lessons for current-day pandemic response. this article, which examines local arc responses in boston, pittsburgh, st. louis, and richmond, virginia, demonstrates how the arc coordinated nursing for military and civilian cases; produced and procured medical supplies and food; transported patients, health workers, and bodies; and aided influenza victims' families. but the organization's eff ... | 2010 | 20568571 |
| the relationship between diabetes mellitus and exfoliation syndrome in a united states veterans affairs population: a case-control study. | earlier studies suggest that an inverse relationship exists between diabetes mellitus and exfoliation syndrome (es). we evaluated the relationship between diabetes mellitus and es while controlling for important covariates. in addition, we investigated whether glucose control, as measured by glycosylated hemoglobin (hba1c) levels, differed between the subset of diabetic patients with and without es. | 2010 | 20577098 |
| operation everest ii. | in october 1985, 25 years ago, 8 subjects and 27 investigators met at the united states army research institute for environmental medicine (usariem) altitude chambers in natick, massachusetts, to study human responses to a simulated 40-day ascent of mt. everest, termed operation everest ii (oe ii). led by charlie houston, john sutton, and allen cymerman, these investigators conducted a large number of investigations across several organ systems as the subjects were gradually decompressed over 40 ... | 2010 | 20586595 |
| storefront cigarette advertising differs by community demographic profile. | tobacco manufacturers have targeted youth and ethnic/racial minorities with tailored advertising. less is known about how characteristics of storefront tobacco advertisements, such as location, position, size, and content, are used to appeal to demographic subgroups. | 2010 | 20594091 |
| cognitive and behavioral characterization of 16p11.2 deletion syndrome. | to describe cognitive and behavioral features of patients with chromosome 16p11.2 deletion syndrome, a recently identified and common genetic cause of neurodevelopmental disability, especially autism spectrum disorder (asd). | 2010 | 20613623 |
| prenatal exposure to cigarette smoke and benign breast disease. | experimental studies have indicated that cigarette smoke contains potential human breast toxins and that the toxic influence during the prenatal period is greater than that of later life. | 2010 | 20631621 |
| institutional review board challenges related to community-based participatory research on human exposure to environmental toxins: a case study. | we report on the challenges of obtaining institutional review board (irb) coverage for a community-based participatory research (cbpr) environmental justice project, which involved reporting biomonitoring and household exposure results to participants, and included lay participation in research. | 2010 | 20637068 |
| the apoa1/c3/a4/a5 cluster and markers of allostatic load in the boston puerto rican health study. | background and aims: the apoa1/c3/a4/a5 cluster encodes key regulators of plasma lipids. interactions between dietary factors and single nucleotide polymorphisms (snps) in the cluster have been reported. allostatic load, or physiological dysregulation in response to stress, has been implicated in shaping health disparities in ethnic groups. we aimed to determine the association between polymorphisms in the apoa1/c3/a4/a5 cluster with allostatic load parameters, alone, and in interaction with die ... | 2010 | 20674306 |
| cost-effectiveness of using social networks to identify undiagnosed hiv infection among minority populations. | in 2003, the centers for disease control and prevention launched the advancing hiv prevention project to implement new strategies for diagnosing human immunodeficiency virus (hiv) infections outside medical settings and prevent new infections by working with hiv-infected persons and their partners. | 2010 | 20689396 |
| expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. | the overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities. | 2010 | 20700038 |
| prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of congenital anomalies: a retrospective cohort study. | prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (pce) have shown increases in the risk of certain congenital anomalies among exposed offspring. | 2009 | 19778411 |
| cleft palate in pfeiffer syndrome. | the frequency of associated cleft palate is known to be high in some fibroblast growth factor receptor 2 (fgfr2)-mediated craniosynostosis syndromes, such as apert syndrome. however, there is little information on the frequency of palatal clefts in the fgfr2-mediated disorder, that is, pfeiffer syndrome. the purpose of this study was to determine the frequency of palatal clefts in patients with pfeiffer syndrome. the records of patients with pfeiffer syndrome managed in our craniofacial unit wer ... | 2009 | 19816260 |
| evidence-based practice, clinical simulations workshop, and intravenous medications: moving toward safer practice. | in an era of increased emphasis on medication safety practice, a gap exists in the translation of research to clinical practice for administering intravenous continuous infusion medications. an educational initiative was designed for medical-surgical nurses in a tertiary care center to standardize operational procedures in a clinical model focusing on evidence-based practice. | 2009 | 19591361 |
| formation of personal hiv disclosure policies among hiv-positive men who have sex with men. | given the increasing emphasis on "prevention with positives" programs designed to promote hiv transmission risk reduction among people living with hiv/aids, better understanding of influences upon serostatus disclosure in sexual situations is needed. based on grounded theory analyses of individual interviews, this exploratory research hypothesizes and interprets how 15 hiv-positive men who have sex with men (msm) formed personal hiv disclosure policies for sexual situations. participants describ ... | 2009 | 19621994 |
| metapopulation structure for perpetuation of francisella tularensis tularensis. | outbreaks of type a tularemia due to francisella tularensis tularensis are typically sporadic and unstable, greatly hindering identification of the determinants of perpetuation and human risk. martha's vineyard, massachusetts has experienced an outbreak of type a tularemia which has persisted for 9 years. this unique situation has allowed us to conduct long-term eco-epidemiologic studies there. our hypothesis is that the agent of type a tularemia is perpetuated as a metapopulation, with many sma ... | 2009 | 19627585 |
| the effects of abcg5/g8 polymorphisms on plasma hdl cholesterol concentrations depend on smoking habit in the boston puerto rican health study. | low hdl-cholesterol (hdl-c) is associated with an increased risk for atherosclerosis, and concentrations are modulated by genetic factors and environmental factors such as smoking. our objective was to assess whether the association of common single-nucleotide polymorphisms (snps) at abcg5/g8 (i18429g>a, i7892t>c, gln604gluc>g, 5u145a>c, tyr54cysa>g, asp19hisg>c, i14222a>g, and thr400lysc>a) genes with hdl-c differs according to smoking habit. abcg5/g8 snps were genotyped in 845 participants (24 ... | 2009 | 19005228 |
| colostrum iodine and perchlorate concentrations in boston-area women: a cross-sectional study. | to measure levels of colostrum iodine, which has not been previously measured, and perchlorate and cotinine (a surrogate for thiocyanate derived from cigarette smoke) in women up to 60 h postpartum. perchlorate and thiocyanate are environmental inhibitors of iodide transport into the thyroid and lactating breast. | 2009 | 18616704 |
| cardiovascular, inflammatory, and metabolic consequences of sleep deprivation. | that insufficient sleep is associated with poor attention and performance deficits is becoming widely recognized. fewer people are aware that chronic sleep complaints in epidemiologic studies have also been associated with an increase in overall mortality and morbidity. this article summarizes findings of known effects of insufficient sleep on cardiovascular risk factors including blood pressure, glucose metabolism, hormonal regulation, and inflammation with particular emphasis on experimental s ... | 2009 | 19110131 |
| tcf7l2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the framingham heart study. | common variants in the tcf7l2 gene are associated with type 2 diabetes via impaired insulin secretion. one hypothesis is that variation in tcf7l2 impairs insulin processing in the beta cell. in contrast, the association of related tcf7l2 polymorphisms with obesity is controversial in that it has only been shown in cohorts susceptible to ascertainment bias. we reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a tcf7l2 h ... | 2009 | 19183934 |
| improving the health of diabetic patients through resident-initiated group visits. | group visits have the potential to benefit patients with chronic illnesses. our objective was to implement resident-run diabetic group visits that would improve patient education and help patients become more involved in their care. | 2009 | 19184689 |
| polybrominated diphenyl ether (pbde) concentrations in house dust are related to hormone levels in men. | despite documented widespread human exposure to polybrominated diphenyl ethers (pbdes) through dietary intake and contact with or inhalation of indoor dust, along with growing laboratory evidence for altered endocrine function following exposure, human studies of pbde exposure and endocrine effects remain limited. we conducted a preliminary study within an ongoing study on the impact of environmental exposures on male reproductive health. we measured serum hormone levels and pbde concentrations ... | 2009 | 19211133 |
| the effect of angiotensin-blocking agents on liver fibrosis in patients with hepatitis c. | multiple studies implicate the renin-angiotensin system in hepatic fibrogenesis. few studies have examined the effects of angiotensin blockade on liver fibrosis via human histology. | 2009 | 19220742 |
| antiviral and antibiotic prescribing for influenza in primary care. | anti-influenza antiviral medications reduce influenza-related morbidity, but may often be used inappropriately. | 2009 | 19225847 |
| participant experiences in a breastmilk biomonitoring study: a qualitative assessment. | biomonitoring studies can provide information about individual and population-wide exposure. however they must be designed in a way that protects the rights and welfare of participants. this descriptive qualitative study was conducted as a follow-up to a breastmilk biomonitoring study. the primary objectives were to assess participants' experiences in the study, including the report-back of individual body burden results, and to determine if participation in the study negatively affected breastf ... | 2009 | 19226469 |
| a walk in the park: a case study in research ethics. | can researchers, interested in novel ways to assess hiv seroprevalence among populations which are otherwise hidden, collect condoms that have been discarded on the ground in a public sex environment and test them for hiv? researchers, who use other types of abandoned samples, such as discarded syringes, hair or saliva samples, or excess biological samples, confront similar issues. this review evaluates whether such abandoned tissues can be studied based on u.s. code of federal regulations and l ... | 2009 | 19245606 |
| resistin, adiponectin, and risk of heart failure the framingham offspring study. | we tested the association of the adipokines resistin and adiponectin with incident heart failure. | 2009 | 19245965 |
| early adulthood uprooted: transitoriness in young women with breast cancer. | young women with breast cancer face a more aggressive disease and lower survival rate compared with those who are older, thereby confronting the potential finitude of life or transitoriness at a time when they are establishing their careers, developing partnerships, and building families. little is known about the perspectives of young women with breast cancer in how they consider issues of their own mortality. patients with stage i to iii breast cancer aged 39 years and younger who were diagnos ... | 2009 | 19295418 |
| exposure to breast milk in infancy and risk of breast cancer. | early life exposures, such as being breastfed in infancy, may influence the risk of breast cancer in adulthood. we evaluated the risk of breast cancer in relation to ever having been breastfed in infancy among 9,442 women who participated in a population-based, case-control study. cases were identified through cancer registries in three states (massachusetts, new hampshire, and wisconsin); controls were identified through statewide drivers' license lists or medicare lists. data on known and susp ... | 2009 | 19330531 |
| an assessment of sources and pathways of human exposure to polybrominated diphenyl ethers in the united states. | polybrominated diphenyl ethers (pbdes) are ubiquitous in the indoor environment, owing to their use in consumer products ranging from electronics to mattresses, furniture, and carpets. people are exposed to pbdes through inhalation of indoor air and ingestion, and dermal absorption of dust particles present in the air. in this study, concentrations of pbdes were determined in indoor air and house dust collected from homes in albany, new york, usa. based on the measured concentrations of pbdes in ... | 2009 | 19349061 |
| history of space medicine: the formative years at nasa. | almost nothing was known about the effects of spaceflight on human physiology when, in may of 1961, president john f. kennedy committed the united states to land a man on the moon and return him safely to earth within the decade. there were more questions than answers regarding the effects of acceleration, vibration, cabin pressure, co2 concentration, and microgravity. there were known external threats to life, such as solar and ultraviolet radiation, meteorites, and extreme temperatures as well ... | 2009 | 19378903 |
| p53 arg72pro and mdm2 t309g polymorphisms, histology, and esophageal cancer prognosis. | this study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (snp) in the p53 pathway (p53 arg72pro and mdm2 t309g) in patients with esophageal cancer, and to determine the importance of histologic subtype in the snp-outcome relationships. | 2009 | 19383811 |
| anal human papillomavirus infection is associated with hiv acquisition in men who have sex with men. | human papillomavirus (hpv) is a common sexually transmitted agent that causes anogenital cancer and precancer lesions that have an inflammatory infiltrate, may be friable and bleed. our aim was to determine the association between anal hpv infection and hiv acquisition. | 2009 | 19390418 |
| animal rabies in massachusetts, 1985-2006. | in this study, we review annual rabies data from massachusetts from 1985 to 2006, spanning the introduction of raccoon strain rabies in 1992. of 52,034 animals tested, 9.7% (5,049/52,034) were rabid, representing 26 of over 67 species submitted. bats were the most common rabid animals prior to 1992 (50 of 52), but raccoons (procyon lotor) became the most common rabies-positive species upon arrival of raccoon strain rabies virus (38.2%, 2,728 of 7,138 tested), followed by striped skunks (mephitis ... | 2009 | 19395747 |
| predicting atrial fibrillation. | 2009 | 19410714 | |
| partner notification after std and hiv exposures and infections: knowledge, attitudes, and experiences of massachusetts men who have sex with men. | we assessed boston-area men who have sex with men (msm) in terms of their knowledge of partner notification (pn)/partner counseling and referral services (pcrs) and intentions to use such services if exposed to/infected with a sexually transmitted disease (std) or human immunodeficiency virus (hiv) in the future. | 2009 | 19413033 |
| genome-wide analysis of survival in early-stage non-small-cell lung cancer. | lung cancer, of which 85% is non-small-cell (nsclc), is the leading cause of cancer-related death in the united states. we used genome-wide analysis of tumor tissue to investigate whether single nucleotide polymorphisms (snps) in tumors are prognostic factors in early-stage nsclc. | 2009 | 19414679 |
| insulin-like growth factor levels in cord blood, birth weight and breast cancer risk. | breast cancer incidence and birth weight are higher among caucasian than asian women, and birth size has been positively associated with breast cancer risk. pregnancy hormone levels, however, have been generally lower in caucasian than asian women. we studied components of the insulin-like growth factor (igf) system in cord blood from 92 singleton babies born in boston, usa, and 110 born in shanghai, china, in 1994-1995. cord blood igf-1 was significantly higher among caucasian compared with chi ... | 2009 | 19417744 |
| salt marsh sediment bacteria: their distribution and response to external nutrient inputs. | a primary focus among microbial ecologists in recent years has been to understand controls on the distribution of microorganisms in various habitats. much less attention has been paid to the way that environmental disturbance interacts with processes that regulate bacterial community composition. we determined how human disturbance affected the distribution and community structure of salt marsh sediment bacteria by using denaturing gradient gel electrophoresis of 16s rrna in five different habit ... | 2009 | 19421233 |
| sexual mixing patterns and partner characteristics of black msm in massachusetts at increased risk for hiv infection and transmission. | black men who have sex with men (msm) are at increased risk for hiv infection in the united states compared to other msm. the aim of this study was to investigate black msm's sexual mixing patterns and partner characteristics in relation to sexual risk taking, as a possible explanation for this observed increase in hiv incidence. between january and july 2008, 197 black msm were recruited via modified respondent-driven sampling and completed optional pretest and post-test hiv serological testing ... | 2009 | 19466554 |
| ergonomic and socioeconomic risk factors for hospital workers' compensation injury claims. | hospital workers are a diverse population with high rates of musculoskeletal disorders (msds). the risk of msd leading to workers' compensation (wc) claims is likely to show a gradient by socioeconomic status (ses) that may be partly explained by working conditions. | 2009 | 19479820 |
| impact of tabletop exercises on participants' knowledge of and confidence in legal authorities for infectious disease emergencies. | legal preparedness is a critical component of comprehensive public health preparedness for public health emergencies. the scope of this study was to assess the usefulness of combining didactic sessions with a tabletop exercise as educational tools in legal preparedness, to assess the impact of the exercise on the participants' level of confidence about the legal preparedness of a public health system, and to identify legal issue areas in need of further improvement. | 2009 | 19491605 |
| [sixty years ago, cell cultures finally permitted the poliomyelitis virus to multiply easily]. | in 1949, three american virologists, john f. enders, thomas h. weller and frederick c. robbins, from the harvard medical scholl and working at the children's medical centre, boston, mass., have provoked a true revolution in virology. here, they have succeeded in readily multiplying the three poliomyelitis viruses in vitro, in non-nervous cells cultures. a few years afterwards (1954), they were collectively honoured by the nobel prize of physiology and medicine. this discovery not only has quickl ... | 2009 | 20503638 |
| apolipoprotein a5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in puerto rican older adults. | apoa5 -1131t > c and s19w single nucleotide polymorphisms (snp) have been consistently associated with plasma lipid concentration and metabolic syndrome (mets), alone and in modulation by dietary factors. puerto ricans have a high prevalence of metabolic conditions and high minor allele frequency for these snp, suggesting a possible role in disease for this population. we aimed to determine the association of apoa5 -1131t > c and s19w with plasma lipids and markers of mets, alone and in interact ... | 2009 | 19828688 |
| college men's knowledge, attitudes, and beliefs about the human papillomavirus infection and vaccine. | men enrolled in an urban university participated in focus groups (k=6; n=45) to explore knowledge about human papillomavirus and attitudes toward prophylactic vaccine. results suggest that regardless of whether vaccines become available to men, educational efforts should include them, as men tend to have many misconceptions and do not perceive themselves to be vulnerable. | 2009 | 19837363 |
| five-year clinical follow-up after implantation of the endeavor zotarolimus-eluting stent: endeavor i, first-in-human study. | to evaluate the 5-year clinical outcomes of patients treated with the endeavor zotarolimus-eluting stent (zes) in the endeavor i first-in-human study. | 2009 | 19859958 |
| boston medical center pediatric emergency response to h1n1. | 2009 | 19914494 | |
| relative impact of influenza and respiratory syncytial virus in young children. | we measured the relative impact of influenza and respiratory syncytial virus (rsv) infections in young children in terms of emergency department (ed) visits, clinical care requirements, and overall resource use. | 2009 | 19933730 |
| a view from riggs: treatment resistance and patient authority-xii. examined living: a psychodynamic treatment system. | hospitalized patients with treatment resistant comorbid axis i and ii psychiatric disorders have in common a developmental history that includes a lack of fit between their needs and their human environment. adaptation of their personalities to this environmental failure contributes to these patients' lack of trust in authority. treatment resistance may represent a repetition of this early experience, with the current biological and symptom focus of the field representing yet another insufficien ... | 2009 | 20001200 |
| the frequency of palatal anomalies in saethre-chotzen syndrome. | saethre-chotzen syndrome (scs) is an autosomal dominant disorder with widespread phenotypic variability. cardinal features include coronal synostosis, blepharoptosis, and limb abnormalities. cleft palate can also occur, but there are few reports on its frequency. this study was undertaken to determine the prevalence of palatal anomalies in this population. | 2009 | 19642760 |
| seasonal source-sink dynamics at the edge of a species' range. | the roles of dispersal and population dynamics in determining species' range boundaries recently have received theoretical attention but little empirical work. here we provide data on survival, reproduction, and movement for a virginia opossum (didelphis virginiana) population at a local distributional edge in central massachusetts (usa). most juvenile females that apparently exploited anthropogenic resources survived their first winter, whereas those using adjacent natural resources died of sta ... | 2009 | 19569372 |
| multicenter study of knowledge about human papilloma virus and attitudes among emergency department patients. | we sought to evaluate knowledge of human papilloma virus (hpv) and attitudes toward the hpv vaccine among emergency department (ed) patients. | 2009 | 19576825 |
| integrating research training into residency: tools of human investigation. | although the need for new physician-clinical scientists has never been greater, significant obstacles deter young physicians from careers in clinical research. local and federal programs have sought to stimulate interest in clinical research among young physicians, medical students, and even undergraduates, but few formal programs have specifically focused on stimulating interest among residents in training. the recent implementation of strict duty hours regulations has provided residents with a ... | 2009 | 19707076 |
| be prepared. when a virus outbreak hits, hospital leaders must ready more beds, educate patients, and keep staff in the loop. | it is critical that hospitals and health systems can quickly activate plans to increase bed capacity and stage screening areas in the event of a disease outbreak. another piece of a hospital's emergency plan should include posting information on the homepage for patients. some organizations have implemented tracking and bed management systems to provide clinicians with better visibility on what space is available for triage. communication with staff is crucial during an emergency. whether it is ... | 2009 | 19722324 |
| insulin resistance and risk of incident hypertension among men. | j clin hypertens (greenwich). 2009;11:483-490. (c) 2009 wiley periodicals, inc.the independent association between insulin resistance and the development of hypertension remains in doubt because insulin resistance correlates with other metabolic factors also proposed to be associated with hypertension. the authors examined the association between the insulin sensitivity index and incident hypertension in a prospective nested case-control study among 1453 men (mean age, 61 years) who participated ... | 2009 | 19751460 |
| brief report: lymphocytic choriomeningitis virus transmitted through solid organ transplantation--massachusetts, 2008. | lymphocytic choriomeningitis virus (lcmv) is a rodent-borne arenavirus found worldwide. house mice (mus musculus) are the natural reservoir, but lcmv also can infect other wild, pet, and laboratory rodents (e.g., rats, mice, guinea pigs, and hamsters). humans can be infected through exposure to rodent excreta. person-to-person transmission has occurred only through maternal-fetal transmission and solid organ transplantation. lcmv infection in humans can be asymptomatic or cause a spectrum of ill ... | 2008 | 18650788 |
| repetitive stress symptoms in radiology: prevalence and response to ergonomic interventions. | to determine the prevalence of repetitive stress symptoms among radiologists working in a archiving and communication systems (pacs) environment and to assess their responses to ergonomic interventions. | 2008 | 18657788 |
| fatal fires associated with smoking during long-term oxygen therapy--maine, massachusetts, new hampshire, and oklahoma, 2000-2007. | approximately 1 million persons in the united states receive long-term oxygen therapy (ltot) annually through the medicare program, most often for smoking-related lung disease. at 2:10 a.m. on december 14, 2007, a fire occurred in a public housing project for the elderly in westbrook, maine. approximately 60 residents were evacuated; six were transported to a hospital for smoke inhalation. the fire was caused unintentionally by a woman aged 57 years who was an overnight guest of a relative who l ... | 2008 | 18685553 |
| discussions about preventive services: a qualitative study. | elderly minority patients are less likely to receive influenza vaccination and colorectal cancer screening than are other patients. communication between primary care providers (pcps) and patients may affect service receipt. | 2008 | 18768086 |
| talc use, variants of the gstm1, gstt1, and nat2 genes, and risk of epithelial ovarian cancer. | epidemiologic evidence suggests a possible association between genital use of talcum powder and risk of epithelial ovarian cancer; however, the biological basis for this association is not clear. we analyzed interactions between talc use and genes in detoxification pathways [glutathione s-transferase m1 (gstm1), glutathione s-transferase t1 (gstt1), and n-acetyltransferase 2 (nat2)] to assess whether the talc/ovarian cancer association is modified by variants of genes potentially involved in the ... | 2008 | 18768514 |
| point-of-care glucose and hemoglobin a1c in emergency department patients without known diabetes: implications for opportunistic screening. | the objectives were to evaluate the correlation between random glucose and hemoglobin a1c (hba1c) in emergency department (ed) patients without known diabetes and to determine the ability of diabetes screening in the ed to predict outpatient diabetes. | 2008 | 18785943 |
| patient risks, outcomes, and costs of voluntary hiv testing at five testing sites within a medical center. | the centers for disease control and prevention (cdc) recommends offering human immunodeficiency virus (hiv) testing to all patients in all high hiv-prevalence clinical settings. we evaluated programmatic aspects of hiv testing across multiple clinical settings within a single medical center. | 2008 | 18828416 |
| outbreak of listeria monocytogenes infections associated with pasteurized milk from a local dairy--massachusetts, 2007. | on november 27, 2007, a local health officer in central massachusetts contacted the massachusetts department of public health (mdph) to report listeriosis in a man aged 87 years. pulsed-field gel electrophoresis (pfge) performed on the patient's listeria monocytogenes isolate produced a pattern indistinguishable from that of isolates from three other cases identified in residents of central massachusetts in june, october, and early november 2007. mdph, in collaboration with local public health o ... | 2008 | 18846031 |
| acculturation of host individuals: immigrants and personal networks. | there has been a vast amount of research on the changes experienced by immigrants, but little is known about the changes experienced by host individuals. this article focuses on the role of host individuals in the networks of relations between immigrant populations and the communities from the dominant culture, as well as the changes experienced by host individuals because of their continuous contact with immigrants. this research applied a network approach to the study of the acculturation of h ... | 2008 | 18923893 |
| using stem cells and reprogramming to understand disease. | kevin eggan received his phd in biology from the massachusetts institute of technology in february 2003. he is currently an assistant professor of stem cell and regenerative biology at harvard university. dr eggan has devoted the last 7 years to performing stem cell research. he is currently leading a research group that is investigating the mechanisms regulating epigenetic reprogramming after somatic cell nuclear transfer and using nuclear transfer techniques to derive disease-specific human em ... | 2008 | 18947303 |
| influenza vaccination in adolescents with high-risk conditions. | we assessed influenza vaccination rates from 1992 to 2002, individual continuity of vaccination, and missed opportunities for vaccination in adolescents with high-risk conditions. | 2008 | 18977969 |
| personal genomes: a disruptive personality, disrupted. | 2008 | 18987711 | |
| movie magic in the clinic: computer-generated characters for automated health counseling. | in this presentation, i demonstrate how many of the technologies used in movie special effects and games have been successfully used in health education and behavior change interventions. computer-animated health counselors simulate human face-to-face dialogue as a computer interface medium, including not only verbal behavior but nonverbal conversational behavior such as hand gesture, body posture shifts, and facial display of emotion. this technology has now been successfully used in a wide ran ... | 2008 | 18999232 |
| elevated house dust and serum concentrations of pbdes in california: unintended consequences of furniture flammability standards? | studies show higher house dust and body burden levels of pbde flame retardants in north america than europe; but little is known about exposure variation within north america, where california's furniture flammability standard affects pbde use. we compared dust samples from 49 homes in two california communities with 120 massachusetts homes and with other published studies. dust concentrations [median (range) ng/g] in california homes of bde-47, -99, and -100 were 2700 (112-107,000), 3800 (102-1 ... | 2008 | 19031918 |
| shire dumps dynepo. | 2008 | 19060856 | |
| using the rate of positive high-risk hpv test results for asc-us together with the asc-us/sil ratio in evaluating the performance of cytopathologists. | we reviewed our experience with 2 indicators of cytopathologist performance: the relative frequency of the interpretations atypical squamous cells of undetermined significance (asc-us) and squamous intraepithelial lesion (sil) and the frequency of positive test results for high-risk human papillomavirus (hr-hpv) dna associated with a cytologic interpretation of asc-us. data derived for 9 cytopathologists were reviewed. asc-us/sil ranged from 0.99 to 4.02 (mean, 1.77) in 2005 and from 0.82 to 3.6 ... | 2008 | 18089494 |
| observed finger behaviour during computer mouse use. | two-button computer mouse users may exhibit sustained, static finger lifting behaviours to prevent inadvertent activations by avoiding finger pressure on the buttons, which leads to prolonged, static finger extensor muscle loading. one hundred graduate students were observed during normal computer work in a university computer facility to qualify and quantify the prevalence of lifted finger behaviours and extended finger postures, as well as wrist/forearm and grip behaviour, during specific mous ... | 2008 | 17400173 |
| expanding global hiv treatment: case studies from the field. | in the last 25 years, human immunodeficiency virus (hiv) has become the leading infectious killer of adults globally, with an estimated 44 million people infected with the virus worldwide. most of these individuals live in poor regions of the world, particularly sub-saharan africa. although a great deal of work has been done in identifying and treating individuals with the disease, there has been little action to date to address the complex socioeconomic factors that lie at the heart of this glo ... | 2008 | 17954668 |
| maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. | viral exposure during gestation is thought to be a risk factor for schizophrenia. previous studies have indicated that prenatal exposure to herpes simplex virus type 2 (hsv-2) may be a risk for the subsequent development of schizophrenia in some populations. in this investigation, we tested a large and diverse population to assess the risk of psychoses among offspring of mothers with serological evidence of hsv-2 infection. | 2008 | 17981263 |
| ppargc1a variation associated with dna damage, diabetes, and cardiovascular diseases: the boston puerto rican health study. | individuals with type 2 diabetes exhibit higher dna damage and increased risk of cardiovascular disease (cvd). however, mechanisms underlying the association between dna damage and development of type 2 diabetes and cvd are not understood. we sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (ppargc1a), a master transcriptional regulator of mitochondrial oxidative phosphorylation and cellular energy metabolism, with dna damage, type 2 diabetes, and cvd. | 2008 | 18162502 |
| pcb-containing wood floor finish is a likely source of elevated pcbs in residents' blood, household air and dust: a case study of exposure. | polychlorinated biphenyls (pcbs) are persistent pollutants identified worldwide as human blood and breast milk contaminants. because they bioaccumulate, consumption of meat, fish, and dairy products predicts human blood concentrations. pcbs were also used widely in building materials, including caulks and paints, but few studies have evaluated the contribution of these exposures to body burden. | 2008 | 18201376 |
| dna sequence variants in the loxl1 gene are associated with pseudoexfoliation glaucoma in a u.s. clinic-based population with broad ethnic diversity. | pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. using a u.s. clinic-based case control sample with broad ethnic diversity, we show that three common snps in loxl1 previously associated with pseudoexfoliation in nordic populations are significantly associated with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. | 2008 | 18254956 |
| evaluation of pathways for release of rift valley fever virus into domestic ruminant livestock, ruminant wildlife, and human populations in the continental united states. | to evaluate the feasibility for rift valley fever virus (rvfv) to enter the continental united states by various routes as well as to identify states in which domestic and wild ruminant and human populations would be most vulnerable to exposure to rvfv. | 2008 | 18279085 |
| social responsibility, international development, and institutional commitment: lessons from the boston university experience. | boston university (bu) has a long history of a strong social mission and commitment to service. in august 2003, bu made an institutional commitment to work with the country of lesotho to tackle the human capital implications of the hiv/aids epidemic. surrounded by south africa, and with a population of two million, lesotho, a stable democracy, suffers the world's third-highest adult hiv prevalence rate of about 24%. the initiation of the program required a substantial initial institutional inves ... | 2008 | 18303358 |
| pediatric population size is associated with geographic patterns of acute respiratory infections among adults. | we measure the association between proportion of children and specific pediatric age groups in a local population with the timing and rate of adult emergency department (ed) utilization for influenza and other acute respiratory infections. | 2008 | 18374453 |
| cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. | particulate air pollution is associated with cardiovascular mortality and morbidity. to help identify mechanisms of action and protective/susceptibility factors, we evaluated whether the effect of particulate matter <2.5 mum in aerodynamic diameter (pm(2.5)) on heart rate variability was modified by dietary intakes of methyl nutrients (folate, vitamins b(6) and b(12), methionine) and related gene polymorphisms (c677t methylenetetrahydrofolate reductase [mthfr] and c1420t cytoplasmic serine hydro ... | 2008 | 18378616 |
| do pediatricians manage influenza differently than internists? | little is known about how pediatricians or internists manage influenza symptoms. recent guidelines on antiviral prescribing by the centers for disease control and prevention (cdc) make almost no distinction between adults and children. our objective was to describe how pediatricians in two large academic medical institutions manage influenza and compare them to internists. | 2008 | 18435850 |
| tipping point, over the top, or just noncompliance as usual? | 2008 | 18457226 | |
| perfluorinated compounds in human milk from massachusetts, u.s.a. | perfluorinated compounds (pfcs), notably perfluorooctanesulfonate (pfos) and perfluorooctanoic acid (pfoa), have been reported in human blood. furthermore, the occurrence of pfcs in the blood of newborn babies, coupled with the need to study the potential association of pfc exposure with birth outcomes in neonates, suggests the need for determining the sources and magnitude of exposure in infants. in this study, nine pfcs were measured in 45 human breast milk samples collected in 2004 from massa ... | 2008 | 18497172 |
| moving nursing science forward within the framework of the roy adaptation model. | in 1999, the boston-based adaptation in nursing research society associates published their analysis of roy adaptation model-based research. this earlier analysis supported the model's conceptual framework, its adaptive processes, and the influences that effect human responses. the purpose of this article is to describe more recent research within the context of the roy adaptation model's structural framework, and ongoing developments that include expanded research programs, middle-range theory ... | 2008 | 18544788 |
| long-term care facilities: a cornucopia of viral pathogens. | to determine the frequency and types of respiratory viruses circulating in boston long-term care facilities (ltcfs) during a 3-year period. | 2008 | 18557966 |
| risk factors for proteinuria in hiv-infected and -uninfected hispanic drug users. | proteinuria may be an early marker of chronic kidney disease in human immunodeficiency virus (hiv)-infected patients with coexisting chronic hepatitis and/or drug use. minorities are at greater risk of chronic kidney disease. data are limited about risk factors for proteinuria in hispanic drug users with and without hiv infection. | 2008 | 18572293 |
| innovations in the development of cardiac resynchronization therapy devices with defibrillation capability-the boston scientific experience. | cardiac resynchronization therapy (crt) has been clinically proven to improve symptoms, exercise capacity, and quality of life and promote reduction in ventricular dimensions. when combined with a defibrillator (crt-d), significant reductions in all-cause mortality alone and in combination with cause-specific hospitalization have also been demonstrated. we trace boston scientific corporation's experience in the development of crt-d devices from the first human implant worldwide 10 years ago usin ... | 2008 | 20559930 |
| hidde ploegh: immunologist, journeyman. interview by nicole lebrasseur. | from the moment he finished his ph.d., hidde ploegh has been a wanted man. invited to join one institution after another, he always packed with him his keen interests in the immune system. | 2007 | 17984316 |
| effect of sediment remediation on polychlorinated biphenyl concentrations in tomatoes grown near new bedford harbor. | measurements of polychlorinated biphenyl (pcb) congener concentrations and profiles from produce grown near new bedford harbor, massachusetts, usa, before, during, and after remediation of pcb-contaminated sediment are presented. samples of tomatoes collected from locations upwind and downwind relative to harbor contamination are compared with the use of measurements of 47 individual pcb congeners. the pcb concentration in the locally grown tomatoes, as expressed by the sum of congeners, is high ... | 2007 | 18046797 |
| polybrominated diphenyl ethers and organochlorine pesticides in human breast milk from massachusetts, usa. | concentrations of polybrominated diphenyl ethers (pbdes), and organochlorine pesticides (ocps; ddts, hchs, chls, and hcb) were measured in human breast milk samples collected across massachusetts, usa, in 2004. seventeen pbde congeners were found in the samples, ranging in concentration from 0.06 to 1910 ng g(-1) lipid wt. bde-47 (2,2',4,4'-tetrabde), bde-99 (2,2',4,4',5-pentabde), and bde-100 (2,2',4,4',6-pentabde) were the major congeners detected in breast milk samples. overall mean (+/-sd) c ... | 2007 | 17968447 |