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sexual transmission of hepatitis c virus among hiv-infected men who have sex with men --- new york city, 2005--2010.in the united states, an estimated 3.2 million persons are living with hepatitis c virus (hcv) infection. hcv transmission occurs primarily through percutaneous exposure to blood, and persons who inject drugs are at greatest risk for infection. the role of sexual transmission of hcv has not been well defined. however, reports over the past decade, mainly from europe, have implicated sexual transmission of hcv among human immunodeficiency virus (hiv)--infected men who have sex with men (msm). in ...201121775948
exposure to lymphocytic choriomeningitis virus, new york, usa.to the editor: lymphocytic choriomeningitis virus (lcmv) is an arenavirus carried by the house mouse, mus musculus. human infections can range from mild febrile illness to severe encephalitis and disseminated disease (1). infection during pregnancy is associated with teratogenic effects, including congenital hydrocephalus and chorioretinitis (2).201121762607
the ultimate benefit to be derived from the epidemic. 201121750280
interview: commercial translation of cell-based therapies and regenerative medicine: learning by experience.dr haseltine speaks to emily culme-seymour, assistant commissioning editor william a haseltine, phd has an active career in both science and business. he was a professor at harvard medical school and harvard school of public health (ma, usa) from 1976 to 1993, where he was founder and chair of two academic research departments. he is well known for his pioneering work on cancer, hiv/aids and genomics. he has authored more than 200 manuscripts in peer-reviewed journals and is the author of severa ...201121749201
soul whisperers.personal recollections are offered in reflection upon the tragedy of 9/11. the outreach efforts of the blanton-peale institute in conjunction with the health care chaplaincy of new york and the red cross are recalled by ceo emeritus, kathryn madden. a brief clinical study describes the responses of a young man who was one of only a few persons to make it out of the north tower from above the 85th floor. blanton-peale's benefit honorees brian clark, lauren and greg manning are named as survivors ...201121826557
distributions of polyhalogenated compounds in hudson river (new york, usa) fish in relation to human uses along the river.pcbs (as aroclor concentrations) have been extensively examined in fish along the hudson river, but other xenobiotic chemicals in fish have had limited assessment. this study determined concentrations and congener distributions of polybrominated diphenyl ethers (pbdes), polybrominated and polychlorinated dibenzo-p-dioxins and dibenzofurans (pbdd/fs and pcdd/fs), and polychlorinated biphenyls (pcbs) in smallmouth bass and striped bass taken from a 385km reach of the hudson river. concentrations o ...201121742424
lead, mercury, cadmium, chromium, and arsenic levels in eggs, feathers, and tissues of canada geese of the new jersey meadowlands.the new jersey meadowlands are located within the heavily urbanized new york/new jersey harbor estuary and have been subject to contamination due to effluent and runoff from industry, traffic, and homes along the hackensack river and nearby waterways. these extensive wetlands, though heavily impacted by development and pollution, support a wide array of bird and other wildlife species. persistent contaminants may pose threats to birds in these habitats, affecting reproduction, egg hatchability, ...201121679937
exome sequencing identified myo1e and neil1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.to identify gene loci associated with steroid-resistant nephrotic syndrome (srns), we utilized homozygosity mapping and exome sequencing in a consanguineous pedigree with three affected siblings. high-density genotyping identified three segments of homozygosity spanning 33.6ôçëmb on chromosomes 5, 10, and 15 containing 296 candidate genes. exome sequencing identified two homozygous missense variants within the chromosome 15 segment; an a159p substitution in myosin 1e (myo1e), encoding a podocyte ...201121697813
barriers to hiv testing among hiv/aids concurrently diagnosed persons in new york city.: to assess barriers to human immunodeficiency virus (hiv) testing, health care contacts history, and hiv testing history among patients diagnosed concurrently with hiv and acquired immunodeficiency syndrome (aids).201121844723
a survival analysis approach to modeling human fecundity.understanding conception probabilities is important not only for helping couples to achieve pregnancy but also in identifying acute or chronic reproductive toxicants that affect the highly timed and interrelated processes underlying hormonal profiles, ovulation, libido, and conception during menstrual cycles. currently, 2 statistical approaches are available for estimating conception probabilities depending upon the research question and extent of data collection during the menstrual cycle: a su ...201121697247
decelerating spread of west nile virus by percolation in a heterogeneous urban landscape.vector-borne diseases are emerging and re-emerging in urban environments throughout the world, presenting an increasing challenge to human health and a major obstacle to development. currently, more than half of the global population is concentrated in urban environments, which are highly heterogeneous in the extent, degree, and distribution of environmental modifications. because the prevalence of vector-borne pathogens is so closely coupled to the ecologies of vector and host species, this het ...201121829332
agent-based simulation for weekend-extension strategies to mitigate influenza outbreaks.abstract:201121718518
predictors of acceptance of h1n1 influenza vaccination by fdny firefighters and ems workers.there is a widely recognized need for vaccination of health care workers (hcws). we undertook this study to assess the 2009-2010 h1n1 vaccination rates in ôê+14,000 firefighters and emergency medical service (ems) workers at the fire department of new york (fdny) and to determine predictors of h1n1 vaccine acceptance.201121693157
association of rad51 polymorphism with dna repair in brca1 mutation carriers and sporadic breast cancer risk.abstract:201121708019
heat shock factor y chromosome (hsfy) mrna level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia.to evaluate heat shock factor y chromosome (hsfy) mrna as a biomarker for the presence of retrievable testicular sperm.201121676392
spatial patterns of mercury in biota of adirondack, new york lakes.we studied the spatial distribution patterns of mercury (hg) in lake water, littoral sediments, zooplankton, crayfish, fish, and common loons in 44 lakes of the adirondacks of new york state, usa, a region that has been characterized as a "biological hg hotspot". our study confirmed this pattern, finding that a substantial fraction of the lakes studied had fish and loon samples exceeding established criteria for human and wildlife health. factors accounting for the spatial variability of hg in l ...201121691858
The Rockefeller University Hospital (1910-2010): creating the science of medicine.The year 2010 marked the centennial of the Rockefeller University Hospital, one of the great philanthropic achievements of 20th-century science. For 100 years, the Hospital played a central role in the development and growth of medical science by enabling physician-scientists to make intensive study of human biology and disease. With ingenuity and devotion, they greatly enriched clinical medicine as well as basic biological science. This account emphasizes the founding and first half-century of ...201121857122
Promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism.Aberrant DNA methylation plays a critical role in carcinogenesis, and the availability of dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation. We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study. Real-time methylation-specific PCR was perform ...201121916701
predictive mapping of human risk for west nile virus (wnv) based on environmental and socioeconomic factors.a west nile virus (wnv) human risk map was developed for suffolk county, new york utilizing a case-control approach to explore the association between the risk of vector-borne wnv and habitat, landscape, virus activity, and socioeconomic variables derived from publically available datasets. results of logistic regression modeling for the time period between 2000 and 2004 revealed that higher proportion of population with college education, increased habitat fragmentation, and proximity to wnv po ...201121853103
Fish consumption, low-level mercury, lipids, and inflammatory markers in children.There is considerable evidence that consuming fish has numerous health benefits, including a reduced risk of cardiovascular disease. However, fish is also the primary source of human exposure to mercury (Hg). In a cross-sectional study of 9-11 year old children (N=100), we measured fish consumption, blood lipids, total blood Hg, diurnal salivary cortisol (4 samples collected throughout the day), and performed a proteomic analysis of serum proteins using spectral count shotgun proteomics. Childre ...201122030286
acute illnesses associated with insecticides used to control bed bugs--seven states, 2003--2010.the common bed bug, cimex lectularius, is a wingless, reddish-brown insect that requires blood meals from humans, other mammals, or birds to survive. bed bugs are not considered to be disease vectors, but they can reduce quality of life by causing anxiety, discomfort, and sleeplessness. bed bug populations and infestations are increasing in the united states and internationally. bed bug infestations often are treated with insecticides, but insecticide resistance is a problem, and excessive use o ...201121937972
Temporal variability in urinary concentrations of perchlorate, nitrate, thiocyanate and iodide among children.Perchlorate, nitrate and thiocyanate are ubiquitous in the environment, and human exposure to these chemicals is accurately measured in urine. Biomarkers of these chemicals represent a person's recent exposure, however, little is known on the temporal variability of the use of a single measurement of these biomarkers. Healthy Hispanic and Black children (6-10-year-old) donated urine samples over 6 months. To assess temporal variability, we used three statistical methods (n=29; 153 urine samples) ...201122166811
bat rabies and human postexposure prophylaxis, new york, usa. 201122172493
a randomized trial of a behavioral intervention for black men who have sex with men: the dish study.objective:: to test a new behavioral intervention for black men who have sex with men in reducing sexual risk and increasing social support and intentions to use condoms. design:: a single site, unblinded randomized trial in new york city with 3-month follow-up. methods:: participants (n = 283) reporting at least 2 sexual partners and unprotected anal intercourse with a man in the past 3 months were enrolled and randomized to a social-cognitive theory based intervention or control comparison. me ...201122156967
comparison of health outcomes among affiliated and lay disaster volunteers enrolled in the world trade center health registry.volunteers (non-professional rescue/recovery workers) are universally present at man-made and natural disasters and share experiences and exposures with victims. little is known of their disaster-related health outcomes.201121930152
stem cells. where do human eggs come from? 201121980085
modeling spatial variations of black carbon particles in an urban highway-building environment.highway-building environments are prevalent in metropolitan areas. this paper presents our findings in investigating pollutant transport in a highway-building environment by combing field measurement and numerical simulations. we employ and improve the comprehensive turbulent aerosol dynamics and gas chemistry (ctag) model to simulate the spatial variations of black carbon (bc) concentrations near highway i-87 and an urban school in the south bronx, new york. the results of ctag simulations are ...201122084971
molecular detection of viral causes of encephalitis and meningitis in new york state.the etiology of encephalitis and meningitis, serious diseases of the central nervous system (cns), in most cases remains unknown. the importance of establishing a diagnosis however, becomes even more important as advances are made in effective therapy. molecular methods of detection, in particular, pcr, are being used routinely and have established a place in the arsenal of tools for diagnosis of cns infections. in this study a viral etiological agent was detected by pcr in 340 of the total 2,35 ...201122012726
a community mobilizes to end medical apartheid.problem: people of color suffer worse health outcomes than their white counterparts due, in part, to limited access to high-quality specialty care. purpose: this article describes the events that led to the bronx health reach coalition's decision to file a civil rights complaint with the new york state office of the attorney general alleging that three academic medical centers in new york city discriminated on the basis of payer status and race in violation of title vi of the civil rights ...201122080781
fate of perchlorate in a man-made reflecting pond following a fireworks display in albany, new york, usa.perchlorate is a widespread contaminant in aquatic environments. despite this, the aquatic environmental fate of perchlorate released from fireworks displays is not well known. in the present study, we examined the fate of perchlorate in man-made reflecting ponds, from 2008 to 2010, following three fireworks displays in albany, new york, usa. immediately after the fireworks display, perchlorate in pond waters increased significantly, with concentrations from 30 to 1,480 times higher than the bas ...201121850663
agents of human anaplasmosis and lyme disease at camp ripley, minnesota.the transmission dynamics of anaplasma phagocytophilum (ap) and borrelia burgdorferi (bb) among ixodes scapularis (is) and mammalian hosts was investigated at camp ripley, an area representative of central minnesota. prevalence of white-footed mouse infection with ap and bb were 20% and 42%, respectively, with a coinfection level of 14%. peak levels of infection with both agents occurred in may. the average levels of seropositivity to ap and bb were 29.3% and 48%, respectively. of the mice infec ...201121867420
inotropic contractile reserve can risk-stratify patients with hiv cardiomyopathy: a dobutamine stress echocardiography study.the purpose of this study was to assess whether inotropic contractile reserve (icr) during dobutamine stress echocardiography (dse) could risk-stratify patients with human immunodeficiency virus (hiv) cardiomyopathy and predict improvement of left ventricular ejection fraction (lvef).201122172778
temporally structured metapopulation dynamics and persistence of influenza a h3n2 virus in humans.populations of seasonal influenza virus experience strong annual bottlenecks that pose a considerable extinction risk. it has been suggested that an influenza source population located in tropical southeast or east asia seeds annual temperate epidemics. here we investigate the seasonal dynamics and migration patterns of influenza a h3n2 virus by analysis of virus samples obtained from 2003 to 2006 from australia, europe, japan, new york, new zealand, southeast asia, and newly sequenced viruses f ...201122084096
Evaluating the combined effectiveness of influenza control strategies and human preventive behavior.Control strategies enforced by health agencies are a major type of practice to contain influenza outbreaks. Another type of practice is the voluntary preventive behavior of individuals, such as receiving vaccination, taking antiviral drugs, and wearing face masks. These two types of practices take effects concurrently in influenza containment, but little attention has been paid to their combined effectiveness. This article estimates this combined effectiveness using established simulation models ...201122043275
pneumothorax in a young man in brooklyn, new york. 201122080120
polybrominated diphenyl ethers (pbdes), polychlorinated biphenyls (pcbs) and neuropsychological status among older adults in new york.polybrominated diphenyl ethers (pbdes) are emerging environmental contaminants, but little is known about their possible human health effects. the objective of this study is to evaluate the association between exposure to pbdes and neuropsychological function among older adults and the possibility of effect modification with polychlorinated biphenyls (pcbs). serum samples were analyzed for concentrations of 9 pbde and 30 pcb congeners and 34 tests of cognitive and motor function, affective state ...201122079442
Molting success of Ixodes scapularis varies among individual blood meal hosts and species.The blacklegged tick (Ixodes scapularis) is an important vector of emerging human pathogens. It has three blood-feeding stages, as follows: larva, nymph, and adult. Owing to inefficient transovarial transmission, at least for the Lyme disease agent (Borrelia burgdorferi), larval ticks rarely hatch infected, but they can acquire infection during their larval blood meal. Nymphal ticks are primarily responsible for transmitting pathogens to hosts, including humans. The transition from uninfected ho ...201121845946
first reports of human rotavirus g8p[4] gastroenteritis in the united states.in 2009, three children were hospitalized in rochester, ny with sequence-confirmed g8p[4] rotavirus gastroenteritis-the first us detection of this uncommon strain more typically found in africa. continued monitoring of g8p[4] and other rotavirus genotypes not represented in current vaccines is essential to assess whether vaccination will result in an increase in prevalence of these strains.201122170918
The impact of missed opportunities on seasonal influenza vaccination coverage for healthy young children.To estimate the impact of missed opportunities on influenza vaccination coverage among 6- through 23-month-old children who sought medical care during the 2004-2005 influenza season.201121964369
Serum and follicular fluid ghrelin levels negatively reflect human oocyte quality and in vitro embryo development.To characterize serum and follicular fluid (FF) ghrelin in women undergoing assisted reproduction and to evaluate ghrelin's impact on ovarian steroidogenesis, oocyte quality, and embryo development.201121924713
influenza vaccination and its impact on hospitalization events in nursing homes.objectives: to examine trends of influenza vaccination in nursing homes before and after public reporting (objective-1), and to assess the effect of influenza vaccinations on hospitalization events (objective-2). research design: nursing home compare (nhc) database was used to obtain influenza vaccination rates during the 2005-2006, 2006-2007, and 2007-2008 flu seasons (objective-1). the 2005-2007 minimum data set for new york state (nys) was obtained and linked with the nhc data (objective-2). ...201021450172
syringe exchange programs --- united states, 2008.persons who inject drugs should use a new, sterile needle and syringe for each injection. syringe exchange programs (seps) provide free sterile syringes and collect used syringes from injection-drug users (idus) to reduce transmission of bloodborne pathogens, including human immunodeficiency virus (hiv), hepatitis b virus, and hepatitis c virus (hcv). as of march 2009, a total of 184 seps were known to be operating in 36 states, the district of columbia (dc), and puerto rico (north american syri ...201021085091
linking emergency preparedness and health care worker vaccination against influenza: a novel approach.health care workers (hcws) can acquire and transmit influenza to their patients and coworkers, even while asymptomatic. the u.s. healthy people 2010 initiative set a national goal of 60% coverage for hcw influenza vaccination by 2010. yet vaccination rates remain low. in the 2008-2009 influenza season, flushing hospital medical center (fhmc; new york) adopted a "push/pull" point-of-dispensing (pod) vaccination model that was derived from emergency preparedness planning for mass vaccination and/o ...201021090019
peak cardiac power measured noninvasively with a bioreactance technique is a predictor of adverse outcomes in patients with advanced heart failure.peak oxygen consumption (vo(2) ) during cardiopulmonary exercise testing (cpet) is a powerful predictor of survival, providing an indirect assessment of cardiac output (co). noninvasive indices of co derived from bioreactance methodology would add significantly to peak vo(2) as a means of risk-stratifying patients with heart failure. in this study, 127 patients (53 ± 14 years of age, 66% male) with heart failure and an average ejection fraction of 31% ± 15% underwent symptom-limited cpet using a ...201021091609
workforce training and education gaps in gerontology and geriatrics: what we found in new york state.this article summarizes data from the 2008 symposium charting the future for new york state workforce training and education in aging: the stakeholder perspective and the 2009 report workforce training and education: the challenge for academic institutions. this research is the outcome of a collaborative state society on aging of new york and new york state office for the aging study on new york state's workforce training and education needs. eight listening sessions were held across new york st ...201021108099
hospitalizations for tuberculosis in new york city: how many could be avoided?to determine which factors were associated with hospitalization for tuberculosis (tb) in new york city (nyc), united states, and to estimate the proportion of potentially avoidable admissions.201021144247
achieving international targets for tuberculosis treatment success among hiv-positive patients in new york city.to review outcomes of human immunodeficiency virus (hiv) positive tuberculosis (tb) patients in new york city (nyc) to determine if the world health organization treatment success target of 85% was met in a setting with ready access to treatment for hiv and tb.201021144248
characterization of interleukin-17-producing regulatory t cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.interleukin (il)-17-producing cd4(+) helper t cells (th17) mediate mucosal immunity and are involved in the pathogenesis of inflammatory bowel disease (ibd). they are believed to arise from the same precursor population as regulatory t (treg) cells, but little is known about how these t-cell subsets interact under chronic inflammatory conditions. we studied th17 and treg cells isolated from intestinal lamina propria of patients with ibd to investigate their role in pathogenesis.201021147109
infectious syphilis among adolescent and young adult men: implications for human immunodeficiency virus transmission and public health interventions.background:: in 2008, an increase in syphilis among young black men was noted in new york city (nyc), miami-fort lauderdale, and philadelphia. to explore this trend, we examined infectious syphilis cases from 2000 to 2008 among adolescent and young adult men in these areas. methods:: descriptive analysis of male infectious syphilis cases reported to public health authorities in nyc, fl, and philadelphia. results:: from 2000 to 2008, infectious syphilis cases among males increased in nyc (107-102 ...201021150816
infectious chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma.neutrophilic asthma is thought to be less responsive than eosinophilic asthma to anti-inflammatory therapies including corticosteroids. chlamydia pneumoniae has been implicated in asthma, possibly by induction of interleukin (il-8). we hypothesized that il-8 is increased in the bronchoalveolar lavage (bal) fluid from children with asthma and c. pneumoniae.201021155094
a tribute to seymour steven brody: in memoriam (november 29, 1927 to may 25, 2010).we honor steve brody, a dear friend and a mentor on what would have been his 83rd birthday (november 29, 2010). steve was a pioneer of chlorophyll structure and function, an outstanding biophysicist, an innovator, an artist and an adventurer, a true renaissance man. we present here first his first-of-a-kind contributions on the primary processes of photosynthesis at the university of illinois at urbana-champaign, and then review his research on the interactions of chlorophyll monolayers and vari ...201021161598
gender and age patterns in hsv-2 and hiv infection among non-injecting drug users in new york city.to examine prevalence of and associations between herpes simplex virus type 2 (hsv-2) infection and hiv infection among never-injecting heroin and cocaine drug users (nidus) in new york city.201020838366
oxidant generation capacity of source-apportioned pm2.5.while many studies found associations between ambient particulate matter (pm) and morbidity or mortality outcomes, it is unclear whether these associations were dependent on the composition of pm, which varies with the source of that pm. we address this knowledge gap by conducting a time-series pm-health effects assessment that specifically investigates the role of source-apportioned fine pm (pm2.5) on the oxidant generation capacity that might be responsible for respiratory and cardiovascular h ...201020843277
signs of the 2009 influenza pandemic in the new york-presbyterian hospital electronic health records.in june of 2009, the world health organization declared the first influenza pandemic of the 21(st) century, and by july, new york city's new york-presbyterian hospital (nyph) experienced a heavy burden of cases, attributable to a novel strain of the virus (h1n1pdm).201020844592
post-traumatic stress disorder and hiv: a snapshot of co-occurrence.although the medical advances in the area of human immunodeficiency virus (hiv)/acquired immune deficiency syndrome (aids) have undoubtedly improved the length and quality of life for those who are hiv-affected and medication adherent, there are still many psychosocial obstacles to effective hiv/aids medication adherence. recent research has focused on one such obstacle. the significant link between post-traumatic stress disorder (ptsd) and hiv. this article reports on the nature of this relatio ...201020853209
2009 h1n1 swine flu: the 2010 perspective.in may 2009, as the h1n1 swine flu outbreak was in the early stages, a conference was held at the new york academy of sciences to discuss what was known about the virus and what was being done to stop the outbreak. in may 2010, a follow-up conference was again held at the new york academy of sciences, but now to discuss the h1n1 outbreak retrospectively. the report presented here summarizes the 2010 conference proceedings.201020860673
robert j. doherty, nysda president 2010-2011. humor becomes the man from white plains. 201020863036
factors associated with the ability and willingness of essential workers to report to duty during a pandemic.to determine essential workers' ability and willingness to report to duty during a serious pandemic outbreak and to identify modifiable risk factors.201020881624
a source, a cascade, a schizoid: a heuristic proposal from the longitudinal study of personality disorders.it is argued that personality pathology represents the final emergent product of a complex interaction of underlying neurobehavioral systems as well as environment inputs. a number of factors may be involved in the developmental pathway and a cascading of effects is plausible, although a unifying cascade for all personality disorders is not likely. the present study suggests a possible cascade relevant to one personality disorder: schizoid personality disorder in emerging adulthood. in brief, it ...201020883587
progress in prevention of mother-to-child transmission of hiv in new york state: 1988-2008.to assess the outcomes of efforts to prevent mother-to-child transmission (mtct) of human immunodeficiency virus (hiv) made over the last 2 decades in new york state (nys), through review of data from multiple sources.201020885177
program and policy interventions for preventing mother-to-child transmission of hiv in new york state.mother-to-child transmission (mtct) of human immunodeficiency virus has been virtually eliminated in new york state (nys) in a relatively short time. the dramatic reduction in mtct was achieved through a comprehensive public health program that maximized the benefits of advances in both diagnosis and treatment of hiv infection. the multifaceted program encompassed interventions at multiple levels. it mobilized and engaged medical providers, and it changed clinical practice and the health care de ...201020885178
short communication: no evidence of htlv-3 and htlv-4 infection in new york state subjects at risk for retroviral infection.the primate t-cell lymphoma viruses (ptlv) are divided into six distinct species. the biology and epidemiology of ptlv-1 and ptlv-2 are very well understood. however, that of ptlv-3, 4, 5, and 6 are not. recently, in cameroon, three and one humans were shown to be infected with htlv-3 and htlv-4, respectively. we undertook a study to ascertain whether any of these two retroviruses were present in the peripheral blood mononuclear cell dna of new york state subjects deemed at risk for ptlv infecti ...201020929392
the prevalence of cryptosporidium, and identification of the cryptosporidium horse genotype in foals in new york state.to date, little is known about the prevalence, genotypes and zoonotic potential of cryptosporidium spp. affecting horses, especially in north america. a cross-sectional study was conducted in new york, usa between february 25th and may 1st 2009. fecal samples were collected from three hundred and forty nine 1-10-week-old foals and their dams on 14 different broodmare farms. all fecal samples were screened for cryptosporidium spp. using a direct immunofluorescence assay (dfa). dna extraction and ...201020932647
reflex testing of resected stage i through iii lung adenocarcinomas for egfr and kras mutation: report on initial experience and clinical utility at a single center.the genes kras and egfr have emerged as potential targets for therapy in lung adenocarcinoma; mutations in these genes can be found in almost half of patients. in anticipation of the clinical importance of molecularly defined adenocarcinoma subgroups for the treatment of patients with resected stages i through iii lung adenocarcinoma, the memorial sloan-kettering cancer center (mskcc) departments of surgery and pathology have collaborated since 2006 to conduct reflex testing of tumor specimens f ...201020933246
breast cancer in women with human immunodeficiency virus infection: pathological, clinical, and prognostic implications.aids and breast cancer have become two important public health issues for women. of interest is the prolonged survival of patients diagnosed with hiv infection as a result of the use of highly active antiretroviral therapy (haart). with improved survival, we are likely to see more hiv-infected patients with breast cancer.201020950138
hiv and hcv health beliefs in an inner-city community.summary.  chronic infection with the hepatitis c virus (hcv) is more prevalent than human immunodeficiency virus (hiv) infection, but more public health resources are allocated to hiv than to hcv. given shared risk factors and epidemiology, we compared accuracy of health beliefs about hiv and hcv in an at-risk community. between 2002 and 2003, we surveyed a random patient sample at a primary care clinic in new york. the survey was organized as domains of common sense model of self-regulation: ca ...201020950406
biodiversity on broadway--enigmatic diversity of the societies of ants (formicidae) on the streets of new york city.each year, a larger proportion of the earth's surface is urbanized, and a larger proportion of the people on earth lives in those urban areas. the everyday nature, however, that humans encounter in cities remains poorly understood. here, we consider perhaps the most urban green habitat, street medians. we sampled ants from forty-four medians along three boulevards in new york city and examined how median properties affect the abundance and species richness of native and introduced ants found on ...201020957156
genomewide linkage and peakwide association analyses of carotid plaque in caribbean hispanics.atherosclerosis is a complex subclinical cardiovascular disorder with a substantial genetic component. this study sought to identify genetic loci influencing carotid plaque in 2 independent samples.201020966410
non-specific laboratory test indicators of severity in hospitalized adults with swine influenza (h1n1) pneumonia. 201020967480
reducing drug use, human immunodeficiency virus risk, and recidivism among young men leaving jail: evaluation of the real men re-entry program.this study assesses the impact of real men (returning educated african-american and latino men to enriched neighborhoods), an intervention designed to reduce drug use, risky sexual behavior and criminal activity among 16-18-year-old males leaving new york city jails.201020970079
herpes simplex virus type 2 associated with hiv infection among new york heterosexuals living in high-risk areas.herpes simplex virus type 2 (hsv-2) has been shown to increase the risk of sexual human immunodeficiency virus (hiv) transmission. a matched case-control design was used to examine the association between hsv-2 and hiv infection among heterosexuals in 'high-risk areas' (hras) in new york city (nyc). we identified nyc hras using hiv surveillance data on heterosexual-related adult hiv diagnoses and usa census data on household poverty. heterosexuals who were socially or geographically linked to an ...201020975092
circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults.the specificity and duration of circulating human antibody-secreting cells (ascs) after vaccination have been well described, but characteristics of ascs during acute respiratory infections have not been well studied.201020979459
does pediatrics need its own bioethics?pediatric bioethics raises unique issues because children are constantly growing, developing, and changing. the ethical issues that arise for newborns are different from those that arise for seven-year-olds or 17-year-olds. furthermore, children do not develop cognitive capacities or moral reasoning skills at the same rate. thus, it is difficult to generalize about what is appropriate or inappropriate for children in either the clinical or the research setting. this article responds to some of t ...201021037414
hiv type 2 in new york city, 2000-2008.antibody cross-reactivity complicates differential diagnosis of human immunodeficiency virus (hiv) type 2 (hiv-2) using standard serologic screening and confirmatory tests for hiv. hiv type 1 (hiv-1) viral load testing does not detect hiv-2. although hiv-2 is, in general, less pathogenic than hiv-1, it can lead to immunosuppression and clinical aids, and there are important differences in the selection of antiretroviral therapy for hiv-2-related immunosuppression that make it imperative to diffe ...201021039219
knowledge, attitudes, and practices of us travelers to asia regarding seasonal influenza and h5n1 avian influenza prevention measures.international travel is a potential risk factor for the spread of influenza. in the united states, approximately 5%-20% of the population develops an influenza-like illness annually. the purpose of this study was to describe the knowledge, attitude, and practices of us travelers to asia regarding seasonal influenza and h5n1 avian influenza (ai) prevention measures.201021050316
a rapid, safe, and low-cost technique for the induction of mild therapeutic hypothermia in post-cardiac arrest patients.the benefits of inducing mild therapeutic hypothermia (mth) in cardiac arrest patients are well established. timing and speed of induction have been related to improved outcomes in several animal trials and one human study. we report the results of an easily implemented, rapid, safe, and low-cost protocol for the induction of mth.201021050652
somos: evaluation of an hiv prevention intervention for latino gay men.latino gay men face multiple barriers to human immunodeficiency virus (hiv) prevention, in particular a lack of intervention programs that integrate prevention messages with cultural norms and address issues of social marginalization from multiple communities (gay community and latino community), homophobia and racism. in order to address these specific issues, a multilayered hiv intervention was designed to incorporate and integrate psychosocial and community factors through multiple session gr ...201021059799
phylogeography of the spring and fall waves of the h1n1/09 pandemic influenza virus in the united states.spatial variation in the epidemiological patterns of successive waves of pandemic influenza virus in humans has been documented throughout the 20th century but never understood at a molecular level. however, the unprecedented intensity of sampling and whole-genome sequencing of the h1n1/09 pandemic virus now makes such an approach possible. to determine whether the spring and fall waves of the h1n1/09 influenza pandemic were associated with different epidemiological patterns, we undertook a larg ...201021068250
novel sqstm1 mutations in patients with paget's disease of bone in an unrelated multiethnic american population.more than 20 mutations of the sequestosome 1 (sqstm1) gene have been reported in patients of european descent affected by paget's disease of bone (pdb). in this investigation, a systematic screening for sqstm1 mutations was conducted in consecutively evaluated unrelated patients with phenotypical pdb living in the new york city area (ny, united states). seventy unrelated pdb patients with a multiethnic background, mostly of jewish, italian american, and western european ancestries, were recruite ...201021073987
web-based self-triage of influenza-like illness during the 2009 h1n1 influenza pandemic.the sudden emergence of 2009 h1n1 influenza in the spring of that year sparked a surge in visits to emergency departments in new york city and other communities. a larger, second wave of cases was anticipated the following autumn. to reduce a potential surge of health system utilization without denying needed care, we enlisted the input of experts from medicine, public health, nursing, information technology, and other disciplines to design, test, and deploy clinical algorithms to help minimally ...201020605260
functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.the genetic mechanisms underlying asthma remain unclear. increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (s1pr1) is an essential participant regulating lung vascular integrity and responses to lung inflammation.201020624651
national institute of mental health multisite eban hiv/std prevention intervention for african american hiv serodiscordant couples: a cluster randomized trial.human immunodeficiency virus (hiv) has disproportionately affected african americans. couple-level interventions may be a promising intervention strategy.201020625011
impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants.the goal was to examine the impact of birth at night, on the weekend, and during july or august (the first months of the academic year) and the impact of resident duty-hour restrictions on mortality and morbidity rates for very low birth weight infants.201020643715
toward a methodology for substate projections of registered nurse supply and demand in new york.even as concerns about nursing shortages continue nationwide and for individual states in the united states, there is little information on the impact of nursing shortages at substate levels, such as counties or groups of small counties. national and state level assessments can mask wide geographic variation in the distribution of registered nurses (rns). the center for health workforce studies at the school of public health, university at albany, developed a practical approach to projecting rn ...201020653217
complete nucleotide sequence of the incn plasmid pkox105 encoding vim-1, qnrs1 and shv-12 proteins in enterobacteriaceae from bolzano, italy compared with incn plasmids encoding kpc enzymes in the usa.we determined the complete nucleotide sequence of pkox105, a 54 641 bp plasmid from a klebsiella oxytoca strain that was isolated from a resident of a long-term-care facility in bolzano, italy.201020656680
case fatality rates based on population estimates of influenza-like illness due to novel h1n1 influenza: new york city, may-june 2009.the public health response to pandemic influenza is contingent on the pandemic strain's severity. in late april 2009, a potentially pandemic novel h1n1 influenza strain (nh1n1) was recognized. new york city (nyc) experienced an intensive initial outbreak that peaked in late may, providing the need and opportunity to rapidly quantify the severity of nh1n1.201020657738
conversations with harvey. interview by lori ashcraft and william a anthony. 201020666195
extracellular mass/body cell mass ratio is an independent predictor of survival in peritoneal dialysis patients.malnutrition is a strong predictor of mortality in peritoneal dialysis (pd) patients. extracellular mass (ecm) contains all the metabolically inactive, whereas body cell mass (bcm) contains all the metabolically active, tissues of the body. ecm/bcm ratio is a highly sensitive index of malnutrition. the objective of this study was to explore the relationship between ecm/bcm ratio and survival in pd patients. we enrolled 62 patients from november 2000 to july 2008. on enrollment, demographic, clin ...201020671743
pandemic (h1n1) 2009 surveillance for severe illness and response, new york, new york, usa, april-july 2009.on april 23, 2009, the new york city department of health and mental hygiene (dohmh) was notified of a school outbreak of respiratory illness; 2 days later the infection was identified as pandemic (h1n1) 2009. this was the first major outbreak of the illness in the united states. to guide decisions on the public health response, the dohmh used active hospital-based surveillance and then enhanced passive reporting to collect data on demographics, risk conditions, and clinical severity. this surve ...201020678320
novel influenza a(h1n1) in a pediatric health care facility in new york city during the first wave of the 2009 pandemic.to describe the burden of care experienced by our pediatric health care facility in new york, new york, from may 3, 2009, to july 31, 2009, during the novel influenza a(h1n1) pandemic that began in spring 2009.201020048238
sarcoidosis in world trade center rescue workers presenting with rheumatologic manifestations.the health consequences of the world trade center collapse are unknown, but likely to be significant and may take years to fully appreciate. sarcoidosis is a multisystem inflammatory disorder of unknown etiology characterized pathologically by noncaseating granulomas. inciting events, such as infectious agents or possible environmental exposures, have been postulated as the source of antigen exposure initiating an inflammatory cascade. we describe 2 cases of sarcoidosis in rescue workers with si ...201020051752
patients hospitalized with 2009 pandemic influenza a (h1n1) - new york city, may 2009.the first cases of 2009 pandemic influenza a (h1n1) in new york city occurred in april 2009, raising many questions about how best to contain the epidemic. to rapidly assess the severity of influenza illness and identify persons at highest risk for severe infection, the new york city (nyc) department of health and mental hygiene (dohmh) reviewed the medical charts of the first 99 patients with laboratory confirmed h1n1 admitted to any nyc hospital. the purpose of the review was to characterize t ...201020057350
detecting acute human immunodeficiency virus infection using 3 different screening immunoassays and nucleic acid amplification testing for human immunodeficiency virus rna, 2006-2008.the yield of nucleic acid amplification testing (naat) after routine screening for human immunodeficiency virus (hiv) antibody to detect acute hiv infection (ahi) may vary with different hiv-antibody assays.201020065201
validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and cbmn assays in a mouse model.automation of radiation biodosimetry is one of the top priority tasks considered by the office of science and technology policy and the homeland security council in preparation for the nation's readiness for a possible radionuclear terrorist attack. the center for biophysical assessment and risk management following irradiation, a consortium of researchers and institutions centered at the university of rochester, has been investigating automated scoring of radiation-induced micronucleus formatio ...201020065686
association of a functional polymorphism in the cholesteryl ester transfer protein (cetp) gene with memory decline and incidence of dementia.polymorphisms in the cholesteryl ester transfer protein (cetp) gene have been associated with exceptional longevity and lower cardiovascular risk, but associations with memory decline and dementia risk are unclear.201020068209
ground zero recollections of us public health service nurses deployed to new york city in september 2001.the events of september 11, 2001, set in motion the broadest emergency response ever conducted by the us department of health and human services. in this article, some of the nurses who deployed to new york city in the aftermath of that horrific attack on the united states offer their recollections of the events. although public health service commissioned corps (phs cc) officers participated in deployments before 9/11, this particular deployment accelerated the transformation of the phs cc, bec ...201020510700
utilization of an incident command system for a public health threat: west nile virus in nassau county, new york, 2008.the summer of 2008 in nassau county, new york, was marked by a historic season of human west nile virus illness and west nile virus activity in mosquitoes. the commissioner of health of the state of new york declared a public health threat, and a decision was made to use adulticide for mosquito control. in contrast to prior years, the nassau county department of health utilized the incident command system (ics) to coordinate a multidisciplinary and multidepartment response to this public health ...201020520369
mutational analysis of hoxa2 and six2 in a bronx population with isolated microtia.microtia is a developmental malformation of the external ear with genetic and environmental causes. the prevalence of microtia varies but several studies suggest increased incidence in hispanic and african american populations. no causal genetic mutations have been identified in these populations. mutations in the homeobox gene hoxa2 caused microtia in a single iranian family. another homeobox gene, six2, acts downstream of hoxa2 during development and provides another possible candidate for mut ...201020542577
the 1918 influenza epidemic in new york city: a review of the public health response.new york city approached the 1918 influenza epidemic by making use of its existing robust public health infrastructure. health officials worked to prevent the spread of contagion by distancing healthy new yorkers from those infected, increasing disease surveillance capacities, and mounting a large-scale health education campaign while regulating public spaces such as schools and theaters. control measures, such as those used for spitting, were implemented through a spectrum of mandatory and volu ...201020568569
"better off in school": school medical inspection as a public health strategy during the 1918-1919 influenza pandemic in the united states.during the 1918-1919 influenza pandemic in the united states, most cities responded by implementing community mitigation strategies, such as school closure. however, three cities--new york city, chicago, and new haven, connecticut--diverged from the dominant pattern by keeping their public schools open while the pandemic raged. this article situates the experiences of these three cities in the broader context of the progressive era, when officials and experts put great faith in expanding public ...201020568692
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