Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| body burden of pops of hong kong residents, based on human milk, maternal and cord serum. | this study is one of the very few investigating the body burdens of persistent organic pollutants in residents of hong kong. twenty-nine human milk samples and 21 human blood (and cord blood) samples collected from 2005 were analyzed for pahs, ocps and pcbs levels. higher levels of pahs, ddts and pcbs were detected in human milk samples when compared to maternal serum and cord serum (pahs: milk: 1981 ng g⁻¹ fat, maternal serum: 1461, cord serum: 1158; ddts: 3099, 1934, 1556; pcbs: 49, 41, 40). a ... | 2011 | 20828823 |
| the influence of social-cognitive factors on personal hygiene practices to protect against influenzas: using modelling to compare avian a/h5n1 and 2009 pandemic a/h1n1 influenzas in hong kong. | understanding population responses to influenza helps optimize public health interventions. relevant theoretical frameworks remain nascent. | 2011 | 20949342 |
| cancer risk assessment of polybrominated diphenyl ethers (pbdes) and polychlorinated biphenyls (pcbs) in former agricultural soils of hong kong. | the major objective of this study was to evaluate the carcinogenic risk posed to humans through pbdes and pcbs of changing agricultural land use for recycling of e-waste and open burning of municipal waste. nine locations were selected to represent 6 different types of land use such as e-waste dismantling workshop (ew (dw)) and e-waste open burning site (ew (obs)). the total concentrations for pbdes and pcbs, and the bioaccessibility of pcbs were determined using soxhlet extraction and in vitro ... | 2011 | 21871716 |
| assessment of risk to humans of bisphenol a in marine and freshwater fish from pearl river delta, china. | bisphenol a (bpa) is a high production-volume chemical used in the manufacture of a wide variety of consumer products. however it is also a ubiquitous contaminant that can interfere with endocrine systems of wildlife and humans. china is the "world factory" and the pearl river delta is the major manufacturing center and is consequently polluted. concentrations of bpa in meats of marketable fish had not been previously reported for this region. in the study upon which we report here concentration ... | 2011 | 21700311 |
| humans are equal: lessons to learn from the world health organization prescriptive growth standards. | 2011 | 21636862 | |
| young-onset parkinsonism in a hong kong chinese man with adult-onset hallervorden-spatz syndrome. | neurodegeneration with brain iron accumulation (nbia) is a heterogeneous group of disorders varied in genetic etiologies, clinical presentations, and radiological features. nbia is an iron homeostasis disorder with progressive iron accumulation in the central nervous systems and is clinically characterized by extrapyramidal movement abnormalities, retinal pigmentary changes, and cognitive impairment. panthothenate kinase-associated neurodegeneration (hallervorden-spatz disease) is the commonest ... | 2011 | 21198414 |
| sexually transmitted infections among female sex workers in hong kong: the role of migration status. | female sex workers (fsw) have been considered reservoirs and vectors of sexually transmitted infections (sti) in the community. this study estimated the prevalence of sti/human immunodeficiency virus (hiv) among fsw of various migration and residential status in hong kong and identified possible risk factors. | 2010 | 21199136 |
| how is health a security issue? politics, responses and issues. | in the closing decade of the 20th century the myriad challenges posed by infectious disease in a globalized environment began to be re-conceptualized as threats to national and human security. the most widely applied model for identifying and responding to such threats is securitization theory, as proposed by the copenhagen school. although its analytical framework is generally accepted, its utility remains contested; especially in non-european and non-state settings. the papers in this special ... | 2010 | 20961945 |
| the infection attack rate and severity of 2009 pandemic h1n1 influenza in hong kong. | serial cross-sectional data on antibody levels to the 2009 pandemic h1n1 influenza a virus from a population can be used to estimate the infection attack rates and immunity against future infection in the community. | 2010 | 20964521 |
| situational awareness and health protective responses to pandemic influenza a (h1n1) in hong kong: a cross-sectional study. | whether information sources influence health protective behaviours during influenza pandemics or other emerging infectious disease epidemics is uncertain. | 2010 | 20967280 |
| willingness to accept h1n1 pandemic influenza vaccine: a cross-sectional study of hong kong community nurses. | the 2009 pandemic of influenza a (h1n1) infection has alerted many governments to make preparedness plan to control the spread of influenza a (h1n1) infection. vaccination for influenza is one of the most important primary preventative measures to reduce the disease burden. our study aims to assess the willingness of nurses who work for the community nursing service (cns) in hong kong on their acceptance of influenza a (h1n1) influenza vaccination. | 2010 | 21034439 |
| facing the threat of influenza pandemic - roles of and implications to general practitioners. | the 2009 pandemic of h1n1 influenza, compounded with seasonal influenza, posed a global challenge. despite the announcement of post-pandemic period on 10 august 2010 by the who, h1n1 (2009) virus would continue to circulate as a seasonal virus for some years and national health authorities should remain vigilant due to unpredictable behaviour of the virus. majority of the world population is living in countries with inadequate resources to purchase vaccines and stockpile antiviral drugs. basic h ... | 2010 | 21044300 |
| association of the pou class 2 homeobox 1 gene (pou2f1) with susceptibility to type 2 diabetes in chinese populations. | pou class 2 homeobox 1 (pou2f1), also known as octamer-binding transcription factor-1 (oct-1), is a ubiquitous transcription factor that plays a key role in the regulation of genes related to inflammation and cell cycles. pou2f1 is located on chromosome 1q24, a region with linkage for type 2 diabetes in chinese and other populations. we examined the association of pou2f1 genetic variants with type 2 diabetes in hong kong chinese using two independent cohorts. | 2010 | 21059098 |
| protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in hong kong. | the relationship between seasonal influenza vaccine and susceptibility to 2009 pandemic a/h1n1 virus infection is not fully understood. | 2010 | 21067351 |
| reconstruction of epidemic curves for pandemic influenza a (h1n1) 2009 at city and sub-city levels. | to better describe the epidemiology of influenza at local level, the time course of pandemic influenza a (h1n1) 2009 in the city of hong kong was reconstructed from notification data after decomposition procedure and time series analysis. gis (geographic information system) methodology was incorporated for assessing spatial variation. between may and september 2009, a total of 24415 cases were successfully geocoded, out of 25473 (95.8%) reports in the original dataset. the reconstructed epidemic ... | 2010 | 21078195 |
| risk factors for cervical abnormalities among hong kong chinese women: a large-scale community-based cervical screening program. | we sought to identify the prevalence of and risk factors associated with cervical abnormalities among chinese women in hong kong. | 2010 | 21091197 |
| downregulation of aspp1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome. | gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neoplasms such as choriocarcinomas and the potentially malignant hydatidiform moles, which may develop persistent disease requiring chemotherapy. aspp1, a member of apoptosis-stimulating proteins of p53 (aspps), is a proapoptotic protein that can stimulate apoptosis through its interaction with p53. we evaluated the promoter methylation and expression profiles of aspp1 in different trophoblastic tiss ... | 2010 | 21102414 |
| network analysis of global influenza spread. | although vaccines pose the best means of preventing influenza infection, strain selection and optimal implementation remain difficult due to antigenic drift and a lack of understanding global spread. detecting viral movement by sequence analysis is complicated by skewed geographic and seasonal distributions in viral isolates. we propose a probabilistic method that accounts for sampling bias through spatiotemporal clustering and modeling regional and seasonal transmission as a binomial process. a ... | 2010 | 21124942 |
| pandemic influenza 1918 h1n1 and 1968 h3n2 dna vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades. | alternative influenza vaccines and vaccine production forms are needed as the conventional protein vaccines do not induce broad cross-reactivity against drifted strains. furthermore, fast vaccine production is especially important in a pandemic situation, and broader vaccine reactivity would diminish the need for frequent change in the vaccine formulations. | 2010 | 21138536 |
| pharmacogenetics of esomeprazole or rabeprazole-based triple therapy in helicobacter pylori eradication in hong kong non-ulcer dyspepsia chinese subjects. | our study aimed to assess the effectiveness of esomeprazole or rabeprazole in combination with amoxicillin and clarithromycin for the eradication of helicobacter pylori in hong kong non-ulcer dyspepsia (nud) patients. | 2010 | 20831535 |
| fear appeals and public service advertising: applications to influenza in hong kong. | 2010 | 20845150 | |
| association of srd5a2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in chinese elderly men. | results of recent studies have demonstrated that genetic variants of the enzyme steroid 5α reductase type ii (srd5a2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3α,17β-diol-glucuronide (3α-diol-g). however, this association was not consistently found among different ethnic groups. thus, we aimed to determine whether the association with srd5a2 genetic variations exists in a cohort of healthy chinese elderly men, by examining 2 metaboli ... | 2010 | 20855474 |
| sero-immunity and serologic response to pandemic influenza a (h1n1) 2009 virus in hong kong. | to study the serologic response to the new pandemic influenza a (h1n1) 2009 virus in hong kong, the level of immunity was measured before and after the occurrence of the outbreak, and the titer of antibody to the pandemic influenza a (h1n1) 2009 virus in serum samples of laboratory confirmed cases. the presence of pre-outbreak pandemic influenza a (h1n1) 2009 virus antibodies in 37% of individuals older than >65 years suggested previous exposures to heterologous virus strains may have elicited c ... | 2010 | 20872705 |
| comparison of the incidence of influenza in relation to climate factors during 2000-2007 in five countries. | relatively few international comparisons of the incidence of influenza related to climate parameters have been performed, particularly in the eastern hemisphere. in this study, the incidence of influenza and climate data such as temperature, relative humidity, and rainfall, from cities at different latitudes with contrasting climates: singapore, hong kong (china), ulaanbaatar (mongolia), vancouver (canada), and three australian cities (brisbane, melbourne and sydney) were examined to determine w ... | 2010 | 20872724 |
| influenza and parainfluenza associated pediatric icu morbidity. | to investigate if morbidity in young children admitted to a pediatric intensive care unit (picu with a laboratory proven diagnosis of influenza and parainfluenza infection) had increased. | 2010 | 20882437 |
| possible role of aerosol transmission in a hospital outbreak of influenza. | we examined the role of aerosol transmission of influenza in an acute ward setting. | 2010 | 20942655 |
| the enterovirus 71 epidemic in 2008--public health implications for hong kong. | we compared the epidemiological, clinical and laboratory characteristics of enterovirus 71 (ev71) cases recorded in the epidemic year of 2008 with those of the past decade. | 2010 | 20599410 |
| virologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in hong kong. | to determine virologically confirmed hospitalization rates associated with respiratory syncytial virus (rsv), adenovirus, and parainfluenza viruses in hong kong children. | 2010 | 20622713 |
| the effect of school-based cervical cancer education on perceptions towards human papillomavirus vaccination among hong kong chinese adolescent girls. | objective: to evaluate the effects of school-based cervical cancer education on hong kong chinese adolescent girls. methods: adolescent girls (n=953) in local secondary schools attended a tailored educational program on cervical cancer prevention. self-administered questionnaires were used before and after the program to measure its effects on participants' knowledge, attitude and perceived social norms towards human papillomavirus (hpv) vaccination and their intention to be hpv vaccinated. resu ... | 2010 | 20650592 |
| evidence for geographical and racial variation in serum sex steroid levels in older men. | despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. we designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. | 2010 | 20668046 |
| community psychological and behavioral responses through the first wave of the 2009 influenza a(h1n1) pandemic in hong kong. | little is known about the community psychological and behavioral responses to influenza pandemics. | 2010 | 20677945 |
| diagnostic challenges of human brucellosis in hong kong: a case series in two regional hospitals. | a retrospective analysis of six patients diagnosed with brucellosis in two regional hospitals was carried out. the epidemiological, clinical, and laboratory features were studied. all patients had exposure history. three patients presented with musculoskeletal symptoms, while three had predominantly genitourinary symptoms. one patient did not have fever at presentation. all patients were diagnosed by positive blood culture of brucella melitensis, and the diagnosis was not suspected for all excep ... | 2010 | 20683074 |
| h1n1 influenza virus reassorting in pigs, poses unknown risk to human health. | 2010 | 20699449 | |
| experiences sharing of implementing template-based electronic medical record system (temrs) in a hong kong medical organization. | this paper aims to investigate the efficacy and feasibility of template-based electronic medical record system (temrs) and factors for its successful implementation. a temrs was designed and implemented in one core clinic of a hong kong professional multi-disciplinary medical services provider with four core clinics located in different parts of hong kong. eight doctors participated in the study. surveys and interviews were conducted to acquire the users' feedback and satisfaction level. the des ... | 2010 | 20703758 |
| host-specific 16s rrna gene markers of bacteroidales for source tracking of fecal pollution in the subtropical coastal seawater of hong kong. | this study investigated the diversity of bacteroidales communities in the feces of eight host species in hong kong (subtropical asia), including human (in the form of sewage), cow, pig, horse, cat, dog, rabbit and rat. the analysis of terminal restriction fragment length polymorphism (trflp) in the 16s rrna genes revealed significant differences in bacteroidales communities among all host species, with the exception of dog and cat. manual examination of trflp profiles resulted in six terminal re ... | 2010 | 20705317 |
| enrichment of polycyclic aromatic hydrocarbons (pahs) in mariculture sediments of hong kong. | surface and core sediments collected from six fish farms in hong kong and from reference sites were investigated for the enrichment and sources of polycyclic aromatic hydrocarbons (pahs). moderately high sigmapah16 levels (123-947 ng g(-1), mean: 450 ng g(-1)) were found in the surface aquaculture sediments. in comparison with the sediments from the reference sites, the average enrichment percentage of total organic carbon (toc) and pahs in surface sediments were 21.4 and 43.8%, respectively, an ... | 2010 | 20708314 |
| genetic susceptibility for chronic lymphocytic leukemia among chinese in hong kong. | the genetic basis of chronic lymphocytic leukemia (cll) has not been fully elucidated to date. although it is the most common haematological malignancy in caucasians, it is uncommon among asians. a recent genome-wide scan of cll in caucasians, which was carried out in the uk, identified six variants showing strong association. we attempted to replicate these findings in 71 patients with cll and 1273 controls in hong kong chinese. three of the six variants were significantly associated with cll. ... | 2010 | 20731705 |
| pandemic influenza a (2009-h1n1) infection in paediatric oncology patients in hong kong. | 2010 | 20738303 | |
| exploring determinants of acceptance of the pandemic influenza a (h1n1) 2009 vaccination in nurses. | this study investigated the anticipated vaccination rate against pandemic human influenza a (h1n1) 2009 in the health care setting. self-administered questionnaires were used to assess nurses' acceptance of vaccination against seasonal flu and h1n1. they were sent to nurses by post through various nurses' unions before initiation of the vaccination program. only 13.3% of the respondents planned to receive the h1n1 vaccine, compared with 37.5% for the seasonal influenza vaccine. vaccination again ... | 2010 | 20566229 |
| controlling alcohol-related global health problems. | alcohol's adverse public health impact includes disease, injury, violence, disability, social problems, psychiatric illness, drunk driving, drug use, unsafe sex, and premature death. furthermore, alcohol is a confirmed human carcinogen. the international agency for research on cancer concluded that alcohol causes cancer of the oral cavity, pharynx, larynx, esophagus, liver, colon-rectum, and breast. world cancer research fund/american institute for cancer research concluded that the evidence jus ... | 2010 | 20566555 |
| a single nucleotide polymorphism in apoa5 determines triglyceride levels in hong kong and guangzhou chinese. | single nucleotide polymorphisms (snps) in the apolipoprotein a5 (apoa5) gene have been associated with hypertriglyceridaemia. we investigated which snps in the apoa5 gene were associated with triglyceride levels in two independent chinese populations. in all, 1375 subjects in the hong kong cardiovascular risk factor prevalence study were genotyped for five tagging snps chosen from hapmap. replication was sought in 1996 subjects from the guangzhou biobank cohort study. among the five snps, rs6627 ... | 2010 | 20571505 |
| monitoring of perceptions, anticipated behavioral, and psychological responses related to h5n1 influenza. | the aim of this study was to monitor changes in behavioral and emotional responses to human h5n1 in the community over a 28-month period (from november 2005 to february 2008). | 2010 | 20582562 |
| another nightmare after sars: knowledge perceptions of and overcoming strategies for h1n1 influenza among chronic renal disease patients in hong kong. | in this article i demonstrate the knowledge perceptions of and the preventive health behaviors toward the influenza a h1n1 pandemic, or "human swine flu," among the chronic renal disease patients in hong kong. based on ethnographic data from participant observation in a chronic renal disease patient self-help alliance and semistructured interviews with its 30 members, i demonstrate that the participants' knowledge perceptions of and the adoption of the preventive health behaviors against h1n1 we ... | 2010 | 20363953 |
| quasispecies of the d225g substitution in the hemagglutinin of pandemic influenza a(h1n1) 2009 virus from patients with severe disease in hong kong, china. | the d225g (aspartic acid to glycine) substitution in the hemagglutinin of h1n1 influenza virus may alter its receptor-binding specificity. direct analysis of polymorphisms in 126 amino acids spanning the receptor-binding site in the hemagglutinin of pandemic h1n1 2009 virus from 117 clinical specimens in hong kong found the d225g substitution for 7 (12.5%) of 57 patients with severe disease and for 0 (0%) of 60 patients with mild disease. d225g quasispecies were identified mainly in endotracheal ... | 2010 | 20367331 |
| a defunctioning polymorphism in fcgr2b is associated with protection against malaria but susceptibility to systemic lupus erythematosus. | systemic lupus erythematosus (sle) is a multisystem autoimmune disease more prevalent in people of african and asian origin than caucasian origin. fcgammariib is an inhibitory fc receptor with a critical role in immune regulation. mouse data suggest that fcgammariib deficiency increases susceptibility to autoimmune disease but protects against infection. we show that a snp in human fcgr2b that abrogates receptor function is strongly associated with susceptibility to sle in both caucasians and so ... | 2010 | 20385827 |
| quality of life constructs of chinese people living with hiv/aids. | a range of quality of life (qol) measurements specific for people living with human immunodeficiency virus (hiv)/acquired immune deficiency syndrome (aids) are available. they were, however, developed before or at about the time of introducing highly active antiretroviral therapy (haart) and there has been very little measurement developed from a chinese perspective. a study was therefore undertaken and we report our findings of the first phase, in which chinese people living with hiv/aids in ho ... | 2010 | 20391238 |
| fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. | in a genome-wide association study of 848 blacks with sickle cell anemia, we identified single nucleotide polymorphisms (snps) associated with fetal hemoglobin concentration. the most significant snps in a discovery sample were tested in a replication set of 305 blacks with sickle cell anemia and in subjects with hemoglobin e or beta thalassemia trait from thailand and hong kong. a novel region on chromosome 11 containing olfactory receptor genes or51b5 and or51b6 was identified by 6 snps (lowes ... | 2010 | 20018918 |
| oseltamivir- and amantadine-resistant influenza virus a (h1n1). | 2010 | 20031069 | |
| prevention of nosocomial transmission of swine-origin pandemic influenza virus a/h1n1 by infection control bundle. | after the outbreak of severe acute respiratory syndrome in hong kong, the importance of preventing nosocomial transmission of respiratory viruses has become a top priority in infection control. during the containment and early mitigation phases of the swine-origin influenza virus (s-oiv) a h1n1 pandemic, an infection control bundle consisting of multiple coherent measures was organised by our infection control team to minimise nosocomial transmission. this included repeated open staff forum achi ... | 2010 | 20061056 |
| the natural viral load profile of patients with pandemic 2009 influenza a(h1n1) and the effect of oseltamivir treatment. | the natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza a(h1n1) and the effect of oseltamivir treatment were uncertain. | 2010 | 20061398 |
| full genome analysis of an emerging cluster of human immunodeficiency virus type 1 subtype b infection in hong kong. | with considerable capacity for genetic diversification, new hiv-1 genotypes have been reported over the years. three hiv-1 isolates previously genotyped as b using gag and env sequences were completely sequenced and reanalyzed. several amino acid mutations were found in vif, rev, and nef genes but not in gag or env sequences. these alterations have not previously been reported in hong kong. the investigation of phylogenetic relatedness revealed that a region of the vif of the studied hong kong i ... | 2010 | 20063993 |
| dietary exposure of secondary school students in hong kong to polybrominated diphenyl ethers from foods of animal origin. | this paper reports levels of polybrominated diphenyl ethers (pbdes) in a wide range of foods of animal origin and estimates their dietary exposure for secondary school students in hong kong, china. dietary exposure to pbdes was estimated using local food consumption data obtained from secondary school students in 2000 and the concentrations of pbdes in food samples taken from local market in 2008. the pbde levels on a fresh weight basis for fish ranged from 13 to 6600 pg g(-1), for seafood and s ... | 2010 | 20104380 |
| high prevalence of primary enfuvirtide (enf) resistance-associated mutations in hiv-1-infected patients in hong kong. | enfuvirtide (enf) is a viral fusion inhibitor used in patients failing highly active antiretroviral therapy (haart). mutations associated with enf resistance have been identified within amino acid positions 36-45 of gp41. as enf will be introduced to hong kong, an understanding of the prevalence of naturally occurred enf resistance mutations is important before implementation of enf treatment. | 2010 | 20116329 |
| logistical feasibility and potential benefits of a population-wide passive-immunotherapy program during an influenza pandemic. | treatment strategies for severe cases of pandemic influenza have focused on antiviral therapies. in contrast, passive immunotherapy with convalescent blood products has received limited attention. we consider the hypothesis that a passive-immunotherapy program that collects plasma from a small percentage of recovered adults can harvest sufficient convalescent plasma to treat a substantial percentage of severe cases during a pandemic. we use a mathematical model to estimate the demand and supply ... | 2010 | 20133660 |
| genetic identity of aminoglycoside-resistance genes in escherichia coli isolates from human and animal sources. | a bacterial collection (n=249) obtained in hong kong from 2002 to 2004 was used to investigate the molecular epidemiology of aminoglycoside resistance among escherichia coli isolates from humans and food-producing animals. of these, 89 isolates were gentamicin-sensitive (human n=60, animal n=29) and 160 isolates were gentamicin-resistant (human n=107, animal n=53). overall, 84.1% (90/107) and 75.5% (40/53) of the gentamicin-resistant isolates from human and animal sources, respectively, were fou ... | 2010 | 20185552 |
| de-stigmatising human papillomavirus in the context of cervical cancer: a randomised controlled trial. | to identify the components of a human papillomavirus (hpv) message contributing to reducing the stigma of hpv in cervical cancer. | 2010 | 20186874 |
| residues of persistent organic pollutants (pops) in human milk in hong kong. | data on pesticide body load in the south china region are scarce. here, we report the concentrations of 24 persistent organic pollutants (pops), in 10 pools of human milk samples, collected at 2-6weeks postpartum from 238 primiparous women living in hong kong and south china, who participated in the 2002-2003 who exposure study. residues were determined by gas chromatography with electron capture detector and confirmed by gas chromatography with mass spectrometry. the mean levels of alpha-hch (m ... | 2010 | 20199797 |
| school closure and mitigation of pandemic (h1n1) 2009, hong kong. | in hong kong, kindergartens and primary schools were closed when local transmission of pandemic (h1n1) 2009 was identified. secondary schools closed for summer vacation shortly afterwards. by fitting a model of reporting and transmission to case data, we estimated that transmission was reduced approximately 25% when secondary schools closed. | 2010 | 20202441 |
| modeling and predicting seasonal influenza transmission in warm regions using climatological parameters. | influenza transmission is often associated with climatic factors. as the epidemic pattern varies geographically, the roles of climatic factors may not be unique. previous in vivo studies revealed the direct effect of winter-like humidity on air-borne influenza transmission that dominates in regions with temperate climate, while influenza in the tropics is more effectively transmitted through direct contact. | 2010 | 20209164 |
| linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of hong kong chinese. | the angiotensinogen gene has been linked with human essential hypertension in whites but the relationship in asian populations has been less consistent. this study aimed to examine genetic associations between hypertension and the m235t, t174m, and g-217a polymorphisms of the angiotensinogen gene in chinese siblings. | 2010 | 20216084 |
| heterogeneous mutations of the atp2c1 gene causing hailey-hailey disease in hong kong chinese. | hailey-hailey disease (hhd) is a rare autosomal dominant dermatosis. it causes suprabasilar acantholysis leading to vesicular and crusted erosions affecting the flexures. mutation of atp2c1 gene encoding the human secretory pathway ca(2+) /mn(2+) -atpase (hspca1) was identified to be the cause of this entity. | 2010 | 20236194 |
| multifaceted ergonomic intervention programme for community nurses: pilot study. | this paper is a report of a pilot study conducted to investigate the effect of a tailor-made ergonomic intervention programme for community nurses. | 2010 | 20337794 |
| cd209 (dc-sign) -336a>g promoter polymorphism and severe acute respiratory syndrome in hong kong chinese. | cd209 (dc-sign) is an important c-type lectin which acts a receptor of many pathogens. the single nucleotide polymorphism (snp) -336a>g in the cd209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (hiv-1), mycobacterium tuberculosis, and dengue fever. cd209 facilitates severe acute respiratory syndrome (sars)-coronavirus spike protein-bearing pseudotype driven infection of permiss ... | 2010 | 20359516 |
| outbreak of influenza a (h1n1) virus infection in a nursing school in hong kong. | 2010 | 20415577 | |
| snps of fc-gamma receptor genes and chronic periodontitis. | genetic polymorphisms of host defense genes might increase risk for periodontitis. this case-control study investigated whether 102 single-nucleotide polymorphisms (snps) in fc gamma receptor (fcgr) genes are associated with chronic periodontitis. cases were 190 hong kong chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. genotype cc and allele c of rs445509 (p < 0.0001, or = 0.30) of fcgr3a were significantly more prevalent among c ... | 2010 | 20439936 |
| polycyclic aromatic hydrocarbons (pahs) in different indoor dusts and their potential cytotoxicity based on two human cell lines. | in this study, 55 air-conditioner filter dust samples from six different workplaces including commercial office, secondary school, shopping mall, hospital, electronic factory and manufacturing plant in hong kong were collected for analyses of pah concentration and cytotoxicity. chemical analyses showed that the total pahs ranged from 1.17 to 25.5 microg/g, with the dust samples from manufacturing plant having the highest concentration. mtt (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrasodium ... | 2010 | 20452024 |
| factors in association with acceptability of a/h1n1 vaccination during the influenza a/h1n1 pandemic phase in the hong kong general population. | a random population-based telephone survey (n=301) was conducted among the hong kong general population in july 2009. past history of seasonal influenza vaccination (or=2.59-3.13) was associated with intention to take up a/h1n1 vaccination under three hypothetical scenarios (provided at <hk$100, hk$100-200 and >hk$200). adjusting background variables, other significant factors were identified by stepwise models: perceived side effects (or=0.33), family members' recommendations and friends' accep ... | 2010 | 20457289 |
| development of a dose-response model for sars coronavirus. | in order to develop a dose-response model for sars coronavirus (sars-cov), the pooled data sets for infection of transgenic mice susceptible to sars-cov and infection of mice with murine hepatitis virus strain 1, which may be a clinically relevant model of sars, were fit to beta-poisson and exponential models with the maximum likelihood method. the exponential model (k= 4.1 x l0(2)) could describe the dose-response relationship of the pooled data sets. the beta-poisson model did not provide a st ... | 2010 | 20497390 |
| a novel modeling framework for multilayered soft tissue deformation in virtual orthopedic surgery. | realistic modeling of soft tissue deformation is crucial to virtual orthopedic surgery, especially orthopedic trauma surgery which involves layered heterogeneous soft tissues. in this paper, a novel modeling framework for multilayered soft tissue deformation is proposed in order to facilitate the development of orthopedic surgery simulators. we construct our deformable model according to the layered structure of real human organs, and this results in a multilayered model. the division of layers ... | 2010 | 20503610 |
| avoidance behaviors and negative psychological responses in the general population in the initial stage of the h1n1 pandemic in hong kong. | during the sars pandemic in hong kong, panic and worry were prevalent in the community and the general public avoided staying in public areas. such avoidance behaviors could greatly impact daily routines of the community and the local economy. this study examined the prevalence of the avoidance behaviors (i.e. avoiding going out, visiting crowded places and visiting hospitals) and negative psychological responses of the general population in hong kong at the initial stage of the h1n1 epidemic. | 2010 | 20509887 |
| influence of country of study on student responsiveness to the h1n1 pandemic. | university students, both travelling abroad on holiday or exchange students entering a country, can serve as mobile carriers of infectious diseases during a pandemic, and thus require special attention when considering preventive measures. the objectives of this study were to evaluate student compliance and opinions on preventive measures of a university before and during an h1n1 influenza pandemic, and to explore environmental and behavioural factors that might contribute towards compliance. | 2010 | 20510428 |
| human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy chinese women from hong kong. | to assess the immunogenicity and safety of human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine in chinese women aged 18 to 35 years enrolled from hong kong. | 2010 | 20519752 |
| the epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in hong kong. | to evaluate the epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in hong kong. | 2010 | 20519755 |
| profiling advanced disease in an asian clinical human immunodeficiency virus cohort: comparison of two definitions for acquired immunodeficiency syndrome. | to compare advanced human immunodeficiency virus disease defined immunologically and clinically by evaluating the characteristics of human immunodeficiency virus patients in hong kong. | 2010 | 20519756 |
| outcomes of adults hospitalised with severe influenza. | the aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza. | 2010 | 20522848 |
| epidemiology and clinical features of shewanella infection over an eight-year period. | shewanella is a rare human pathogen that can lead to fatal infections. however, clinical information about this bacterium remains scarce. in this study, we retrospectively reviewed all patients with laboratory isolates of shewanella over an 8-y period to assess risk factors, clinical manifestations and outcome. twenty-nine patients were identified. shewanella was most commonly isolated from intra-abdominal specimens (48.2%), followed by skin and soft tissue specimens (27.6%), blood (13.8%) and s ... | 2010 | 20524786 |
| independent predictive roles of eotaxin ala23thr, paraoxonase 2 ser311cys and beta-adrenergic receptor trp64arg polymorphisms on cardiac disease in type 2 diabetes--an 8-year prospective cohort analysis of 1297 patients. | to examine the independent and joint effects of multiple genetic variants on a cardiac end-point in an 8-year prospective study of a chinese diabetic cohort. | 2010 | 20536507 |
| prevalence of influenza vaccination and associated factors among pregnant women in hong kong. | a total of 568 pregnant women in hong kong were interviewed. of them, 85.4% had heard of influenza vaccine, 21.3% had ever been vaccinated, 3.9% self-reported receiving influenza vaccination (iv) in the 2005/2006 flu season, and 33% were inclined toward receiving iv in the coming year. multivariate analysis showed that those who had been recommended by health care professionals to receive iv during pregnancy were more likely than others to have received iv. other variables related to the health ... | 2010 | 20542072 |
| health risk assessment of abandoned agricultural soils based on heavy metal contents in hong kong, the world's most populated city. | the objective of this study was to evaluate the consequence of changing and using agricultural soils to other purposes in hong kong with respect to risk to human health. this study established concentrations of the following priority elements: as, cu, cd, cr, pb and zn in terms of total burden (using mixed acid microwave digestion) and with respect to metal bioaccessibility (using an in vitro simulated gastric solution). 55 locations were sampled representing 12 different land use types, namely, ... | 2010 | 20552725 |
| detection of novel astroviruses in urban brown rats and previously known astroviruses in humans. | several novel astroviruses have been recently discovered in humans and in other animals. here, we report results from our surveillance of astroviruses in human and rodent faecal samples in hong kong. classical human astroviruses (n=9) and a human mlb1 astrovirus were detected in human faecal samples (n=622). novel astroviruses were detected from 1.6 % of the faecal samples of urban brown rat (rattus norvegicus) (n=441), indicating the prevalence of astrovirus infection in rats might be much lowe ... | 2010 | 20554799 |
| comparative epidemiology of pandemic and seasonal influenza a in households. | there are few data on the comparative epidemiology and virology of the pandemic 2009 influenza a (h1n1) virus and cocirculating seasonal influenza a viruses in community settings. | 2010 | 20558368 |
| reassortment of pandemic h1n1/2009 influenza a virus in swine. | the emergence of pandemic h1n1/2009 influenza demonstrated that pandemic viruses could be generated in swine. subsequent reintroduction of h1n1/2009 to swine has occurred in multiple countries. through systematic surveillance of influenza viruses in swine from a hong kong abattoir, we characterize a reassortant progeny of h1n1/2009 with swine viruses. swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. continued reassortment of ... | 2010 | 20558710 |
| part 4. interaction between air pollution and respiratory viruses: time-series study of daily mortality and hospital admissions in hong kong. | background: populations in asia are not only at risk of harm to their health through environmental degradation as a result of worsening pollution problems but also constantly threatened by recurring and emerging influenza epidemics and. pandemics. situated in the area with the world's fastest growing economy and close to hypothetical epicenters of influenza transmission, hong kong offers a special opportunity for testing environmental management and public health surveillance in the region. in t ... | 2010 | 21446214 |
| the effective reproduction number of pandemic influenza: prospective estimation. | timely estimation of the transmissibility of a novel pandemic influenza virus was a public health priority in 2009. | 2010 | 20805752 |
| increased genetic diversity of hiv-1 circulating in hong kong. | hiv-1 group m strains are characterized into 9 pure subtypes and 48 circulating recombinant forms (crfs). recent studies have identified the presence of new hiv-1 recombinants in hong kong and their complexity continues to increase. this study aims to characterize the hiv-1 genetic diversity in hong kong. phylogenetic analyses were performed by using hiv-1 pol sequences including protease and partial reverse transcriptase isolated from 1045 local patients in hong kong from 2003 to 2008. for the ... | 2010 | 20808942 |
| major pollutants in soils of abandoned agricultural land contaminated by e-waste activities in hong kong. | polycyclic aromatic hydrocarbon (pah), polychlorinated biphenyl (pcb), polybrominated diphenyl ether (pbde) compounds and five heavy metals (cadmium, copper, chromium, lead, and zinc) were determined in soil samples collected from six sites of abandoned agricultural land affected by electronic-waste: e-waste dismantling workshop [ew (dw)], e-waste open burning site [ew (obs)], e-waste storage [ew (s)], and agricultural (a) in the new territories, hong kong. persistent organic pollutants (pops) a ... | 2010 | 20811881 |
| incidence of common respiratory viral infections related to climate factors in hospitalized children in hong kong. | hong kong has a subtropical climate and an influenza seasonality lying approximately mid-way (march-june) between those of the northern (november-march) and southern (june-september) hemispheres. respiratory syncytial virus (rsv) shares a similar seasonality to that of influenza in hong kong and is another important respiratory infection of childhood. daily virus incidence data from public hospitals in hong kong's new territory east cluster, together with hong kong climate data were obtained for ... | 2010 | 19631018 |
| multiplex molecular detection of respiratory pathogens in children with asthma exacerbation. | up to 80% of asthma exacerbations in white children are associated with viral upper respiratory infections. the relative importance of different respiratory pathogens and relevant microbiological data in asian children are unclear. this study elucidated the epidemiology of respiratory infections in hong kong children with asthma exacerbation. | 2010 | 19749009 |
| associations of polymorphisms in the apolipoprotein a1/c3/a4/a5 gene cluster with familial combined hyperlipidaemia in hong kong chinese. | familial combined hyperlipidaemia (fch) is the most common genetic dyslipidaemia associated with coronary artery disease. single nucleotide polymorphisms (snps) and haplotypes in the apoa1/c3/a4/a5 gene cluster are associated with fch in caucasians and with elevated triglycerides (tg) in various ethnic groups. we examined these associations with fch in hong kong chinese. | 2010 | 19732897 |
| sorption and desorption of antibiotic tetracycline on marine sediments. | tetracycline is commonly used for human therapy and veterinary purposes as well as agricultural feed additives. in this study, batch experiments were carried out to investigate the sorption behaviour of tetracycline on marine sediments. the sediment samples were collected from victoria harbour, hong kong. sorption isotherms of tetracycline on marine sediments can be well described by a freudlich model. the calculated k(f) varied from 1.12 to 2.34lg(-1). after h(2)o(2) oxidation for removing the ... | 2010 | 19913873 |
| b cell responses to h5 influenza ha in human subjects vaccinated with a drifted variant. | b cell responses after immunization with a drifted h5 influenza/a/vietnam/1203/04 vaccine were characterized in the peripheral blood of human subjects primed with experimental recombinant h5 influenza a/hong kong/156/97 vaccine. antibody secreting cells were assayed by elispot against a panel of recombinant hemagglutinin and control proteins. increased frequencies of h5 ha-specific antibody secreting and memory b cells could be observed within 7 days of re-vaccination. furthermore, these respons ... | 2010 | 19932673 |
| acceptance of human papillomavirus vaccination among first year female university students in hong kong. | the present study assessed sexual behaviour, knowledge and attitudes among first year university students in order to identify factors that may affect their acceptance of human papillomavirus (hpv) vaccination. a cross-sectional survey was conducted at the chinese university of hong kong in august 2006. the survey was a self-administered questionnaire comprising questions regarding general health, sexual behaviour, knowledge about hpv and cervical cancer, and attitudes towards vaccination. chi2, ... | 2009 | 19917193 |
| detection of an oseltamivir-resistant pandemic influenza a/h1n1 virus in hong kong. | 2009 | 19736041 | |
| the emergence of the novel h1n1 virus: implications for global mental health. | 2009 | 19747424 | |
| methicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistance. | beta-lactam-resistant staphylococci evolved due to widespread nosocomial antibiotic use during the twentieth century, but the last decade has seen the emergence of genotypically distinct resistant bacteria outside hospitals, such as community-acquired methicillin-resistant staphylococcus aureus (ca-mrsa). this changing epidemiology suggests that mechanisms other than direct antibiotic selection could be involved in the spread of bacterial resistance. here we report a 17% prevalence of methicilli ... | 2009 | 19073283 |
| epidemiology and clinical presentations of human coronavirus nl63 infections in hong kong children. | human coronavirus nl63 (hcov-nl63) has been found in children presenting with respiratory tract infections (rtis). however, the epidemiology and clinical course of this newly identified virus have not been fully elucidated. this study investigated the epidemiology, seasonality, and clinical features of hcov-nl63 in hong kong children. this study consisted of two cohorts of children hospitalized in a university-affiliated teaching hospital. in the 12-month retrospective part of the study, reverse ... | 2009 | 19759228 |
| the first novel influenza a (h1n1) fatality despite antiviral treatment and extracorporeal membrane oxygenation in hong kong. | we report the first fatality caused by novel influenza a (h1n1) infection despite having the diagnosis confirmed and being given antiviral treatment after hospitalisation. this patient was also the first with influenza a (h1n1) to be supported with extracorporeal membrane oxygenation in hong kong. although extracorporeal membrane oxygenation is an effective means of supporting patients with refractory hypoxaemia on high mechanical ventilatory support, it is labour-intensive and technically deman ... | 2009 | 19801697 |
| structures of receptor complexes formed by hemagglutinins from the asian influenza pandemic of 1957. | the viruses that caused the three influenza pandemics of the twentieth century in 1918, 1957, and 1968 had distinct hemagglutinin receptor binding glycoproteins that had evolved the capacity to recognize human cell receptors. we have determined the structure of the h2 hemagglutinin from the second pandemic, the "asian influenza" of 1957. we compare it with the 1918 "spanish influenza" hemagglutinin, h1, and the 1968 "hong kong influenza" hemagglutinin, h3, and show that despite its close overall ... | 2009 | 19805083 |
| summaries for patients. the effects of hand washing and facemasks on prevention of influenza infection. | 2009 | 19805764 | |
| pressure ulcer development in older residents in nursing homes: influencing factors. | this paper is a report of a study assessing pressure ulcer incidence and factors affecting pressure ulcer development among older nursing home residents. | 2009 | 19824910 |