Publications

survival characteristics of airborne human coronavirus 229e.	the survival of airborne human coronavirus 229e (hcv/229e) was studied under different conditions of temperature (20 +/- 1 degree c and 6 +/- 1 degree c) and low (30 +/- 5%), medium (50 +/- 5%) or high (80 +/- 5%) relative humidities (rh). at 20 +/- 1 degree c, aerosolized hcv/229e was found to survive best at 50% rh with a half-life of 67.33 +/- 8.24 h while at 30% rh the virus half-life was 26.76 +/- 6.21 h. at 50% rh nearly 20% infectious virus was still detectable at 6 days. high rh at 20 +/ ...	1985	2999318
establishment and maintenance of a persistent infection of l132 cells by human coronavirus strain 229e.	a persistent infection by human coronavirus 229e (hcv/229e) was established in a human continuous cell line (l132). following the initial infection with stock hcv/229e, several cultures were established of which two (hv1 and hv4) have been maintained by continuous passage for two years. these cultures have shed high titres of infectious virus continuously into the supernatant fluid since their initiation. the persistently infected cells were resistant to homologous super-infection but supported ...	1981	6171237
ribonucleoprotein of avian infectious bronchitis virus.	the ribonucleoprotein (rnp) of avian infectious bronchitis virus (ibv) was examined by electron microscopy after shadowing with carbon/platinum. linear rnp strands up to 6.7 microns in length, from three ivb strains, were sensitive to both pancreatic rnase and to proteases. these strands were obtained from spontaneously disrupted complete particles but not from disrupted incomplete particles that lacked rnp. they were also released from nonidet p40-disrupted particles and could be isolated on su ...	1981	6268741
coronavirus isolates sk and sd from multiple sclerosis patients are serologically related to murine coronaviruses a59 and jhm and human coronavirus oc43, but not to human coronavirus 229e.	two coronaviruses (sk and sd), isolated from fresh autopsy brain tissue from two multiple sclerosis patients, were compared with known human and murine coronaviruses. in plaque neutralization assays, antisera prepared against multiple sclerosis isolates sk and sd demonstrated significant cross-reactivity to each other and to murine coronavirus a59, weak cross-reactivity to murine coronavirus jhm, but no cross-reactivity to the human coronavirus 229e. antiserum to sk or sd failed to inhibit hemag ...	1981	7241654
antigenic relationship of the feline infections peritonitis virus to coronaviruses of other species.	utilizing the direct and indirect fluorescent antibody procedure, the antigenic relationship of the feline infectious peritonitis virus (fipv) to 7 other human and animal coronaviruses was studied. fipv was found to be closely related to transmissible gastroenteritis virus (tgev) of swine. transmissible gastroenteritis virus and fipv were in turn antigenically related to human coronavirus 229e (hcv-229e) and canine coronavirus (ccv). an interesting finding in the study was that the 8 coronavirus ...	1978	81044
purification and biophysical properties of human coronavirus 229e.		1976	824815
in vitro antiviral activity and preliminary clinical trials of a new adamantane compound.	a compound, 1'-methyl spiro (adamantane-2,3'-pyrrolidine) maleate, chemically related to the antiviral drug amantadine, was tested for activity in vitro against a number of human respiratory viruses. by a variety of techniques, it was shown to be active against a wide range of human and animal influenza a viruses. the effect was, however, variable and ranged from high activity against two 1957 asian strains to no observable activity against a 1971 strain. like amantadine, the drug did not inhibi ...	1973	4364762
detection of coronavirus 229e antibody by indirect hemagglutination.	tannic-acid treated sheep erythrocytes (fresh or glutaraldehyde preserved) were sensitized with 229e antigens from human embryonic lung (ru-1) cell cultures. indirect hemagglutination (iha) antigen titers in 229e-infected cell cultures paralleled virus infectivity and complement fixation (cf) antigen titers. the identity of the iha antigen was confirmed by testing extracts from inoculated and control cell cultures for ability to inhibit iha. also, significant increases in iha antibody were demon ...	1972	4674373
a new virus isolated from the human respiratory tract.		1966	4285768