Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| hepatitis b virus surface antigen seroconversion in hiv-infected individual after pegylated interferon-alpha treatment: a case report. | hepatitis b virus (hbv) infects from 6 to 14% of hiv-infected individuals. concurrent hiv/hbv infection occurs due to the overlapping routes of transmission, particularly sexual and parenteral. hiv-infected patients that have acute hepatitis b have six times greater risk of developing chronic hepatitis b, with higher viral replication, rapid progression to end-stage liver disease and shorter survival. the coinfection is also associated with poor response to hepatitis b treatment with interferon- ... | 2013 | 24325818 |
| [a case of hepatitis b virus reactivation in a patient with prior resolved hepatitis b infection during bevacizumab plus folfiri treatment]. | hepatitis bvirus (hbv)reactivation induced by cancer chemotherapy is increasingly being observed. however, most reports of resolved hbv[hepatitis bsurface antigen(hbs-ag)negative and hepatitis bsurface antibody(hbs-ab)positive and/or hepatitis bcore antibody(hbc-ab)positive]infection involve patients with hematological malignancies, whereas few describe patients with solid cancers. in this study, we report our experience with a patient with resolved hbv infection who was undergoing bevacizumab p ... | 2013 | 24231716 |
| hepatitis b virus dna integration in tumour tissue of a non-cirrhotic hfe-haemochromatosis patient with hepatocellular carcinoma. | co-existence of multiple causes of liver injury increases the risk of hepatocellular carcinoma (hcc) development. hcc usually develops in patients with cirrhosis although it may also occur in individuals with no or mild liver disease, in particular in cases with hepatitis b virus (hbv) infection. here we report the case of a 43year-old man with hfe-haemochromatosis, seronegative for hepatitis b and c infections, who developed hcc in the absence of severe liver damage. both tumoural and non-tumou ... | 2013 | 22989571 |
| a case of quadruple viral infections and elevated aminotransferase activities. | a 40-year-old man with human immunodeficiency virus (hiv), hepatitis c virus (hcv), and hepatitis b virus (hbv) infection was referred for evaluation of abnormal liver enzyme activities. the patient was maintained on antiretroviral therapy for hiv as well as medication to suppress hbv and had previously undergone treatment for hcv with durable sustained virologic response. the patient was clinically well without any symptoms or evidence of liver decompensation. laboratory findings were notable f ... | 2012 | 22932975 |
| pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis b: a case report. | we present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia. he had a 13-month history of bone pain involving his shoulders, hips, and knee. he received adefovir dipivoxil for treatment of lamivudine-resistant hepatitis b virus infection for 5 years before the occurrence of femoral neck fracture. orthopedic surgeons should be aware of osteomalacia and pathological hip fractur ... | 2012 | 22906214 |
| an 18-year-old man with hepatitis b virus infection and hepatoblastoma. | a young man presented with a large liver mass and positive hepatitis b virus markers. this 18-year-old male has developed ascites, jaundice, high serum alpha fetoprotein (afp) level, liver mass and portal hypertension, without fever or calcification in the mass. all favored the diagnosis of rapidly, progressive hepatocellular carcinoma, however proven hepatoblastoma in liver biopsy. hepatoblastoma usually manifests prior to the third year of life, but can rarely be seen in older children or adul ... | 2012 | 24829653 |
| lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis. | a 69-year-old man was admitted to our hospital in october 2003, for further examination of two liver tumors. he was diagnosed with hepatocellular carcinoma (hcc) arising from decompensated hepatitis b virus (hbv)-related cirrhosis. long-term lamivudine administration improved liver function dramatically despite repeated treatment for hcc. his child-pugh score was 9 points at start of lamivudine treatment, improving to 5 points after 1 year. his indocyanine green at 15 min after injection test sc ... | 2012 | 22654459 |
| complete remission of hepatitis b virus-related membranous nephropathy after entecavir monotherapy. | we reported a case of hepatitis b virus-related membranous nephropathy (hbv-mn) with improvement under an ongoing 4.5-year of entecavir monotherapy. a 37 years old man with a 5 years' history of chronic hepatitis b (chb) who was taken to our department because of proteinuria and microscopic haematuria. a renal biopsy led to a diagnosis of hbv-mn with mesangioproliferative. interferon-alpha 2b (ifn-α2b) was stopped after 24 weeks due to the increasement of hbv-dna and sustained hbeag positive. th ... | 2012 | 22572521 |
| lesions on tattooed skin--a case study. | a man, 33 years of age, presented complaining of asymptomatic lumps on the tattooed skin of his right upper arm. the lumps appeared spontaneously 5 months after getting the tattoo. he had no significant past medical or surgical history. on examination, several 3–4 mm shiny, umbilicated papules were seen on the tattooed skin (figure 1).tests for human immunodeficiency virus (hiv), hepatitis b virus, hepatitis c virus and syphilis were negative and full blood examination was normal. | 2012 | 22558622 |
| simultaneous emergence of entecavir resistance mutations in a nucleoside-naive chronic hepatitis b patient. | entecavir (etv) has potent antiviral activity against hepatitis b virus (hbv), and the emergence of drug resistance is rare in nucleoside-naive patients. resistance requires simultaneous appearance of three mutations which account for the very low resistance profile of etv. we experienced one case of genotypic etv resistance with viral rebound during etv treatment of nucleoside-naive patients with chronic hepatitis b (chb). | 2012 | 22538265 |
| telbivudine myopathy in a patient with chronic hepatitis b. | a 25-year-old man with hepatitis b virus (hbv) infection received antiviral treatment with telbivudine 600 mg daily. six months after starting treatment, the patient developed progressive weakness and myalgia. physical examination showed symmetrical proximal weakness. blood tests at admission revealed positive hepatitis b surface antigen (hbs ag), and, elevated creatine kinase (ck) level (1,614 u/l, normal range: 38-174 u/l). aspartate aminotransferase was 64.7 u/l (normal range: 8-40 u/l), and ... | 2012 | 22527478 |
| diagnosis of small-bowel metastasis of hepatocellular carcinoma by double-balloon enteroscopy. | hepatocellular carcinoma (hcc) is a major cause of cancer-related deaths around the world. nearly half of patients with hcc display metastatic disease at the time of initial diagnosis, frequently involving the liver, bone, brain, lungs, and adrenal glands, but gastrointestinal involvement is rare. melena occurring secondary to a metastatic tumor from hcc is particularly rare. herein, we present a case of melena secondary to metastatic hcc after chemoradiation to lung and brain metastases from hc ... | 2012 | 22503919 |
| the perils of relying on anti-hepatitis b total core antibody in screening individuals infected with hiv. | co-infection with hiv and hepatitis b virus (hbv) has serious long-term consequences. we describe a case of an hiv-infected heterosexual black african man with a delayed diagnosis of hbv infection. baseline hbv screening was performed using a sequential testing algorithm starting with a total core antibody (anti-hbc) test, which was negative. he had no evidence of immunity against hbv and subsequently received three unsuccessful courses of hbv vaccination. he had mild but persistent elevation of ... | 2012 | 22422696 |
| isolated dissection of the superior mesenteric artery after living donor liver transplantation: a case report. | isolated dissection of the superior mesenteric artery (sma) not associated with aortic dissection is rare, particularly after living donor liver transplantation (ldlt). we experienced a case of isolated dissection of the sma after ldlt performed in a 56-year-old man diagnosed with hepatitis b virus-related cirrhosis and hepatocellular carcinoma within the milan criteria. he had no past history of hypertension or diabetes mellitus. at 6 days after ldlt, the patient underwent an emergency portal v ... | 2012 | 22410076 |
| hepatitis b virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy. | retrospective analysis of our local hbv reverse transcriptase (rt) sequence database including 973 sequences recovered from 616 patients identified one unique hbv dna sequence harbouring amino acid (aa) substitution rta194t, which has been suspected to confer reduced susceptibility to tenofovir but whose implication in antiviral resistance has not been confirmed. this sequence has been recovered from the blood sample of a 35-year-old man presenting with chronic hepatitis b and cirrhosis, at time ... | 2012 | 22342116 |
| association of the microrna-499 variants with susceptibility to hepatocellular carcinoma in a chinese population. | micrornas (mirnas) are a new class of small non-coding rnas that function as tumor suppressors or oncogenes. single nucleotide polymorphisms (snps) in mirna may contribute to cancer development. we hypothesized that genetic variations of the mirna could be associated with the risk of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc). a total of 100 patients with hcc, 100 cases of chronic hepatitis b and 100 health adults were enrolled in this present study. two common polymorphisms ... | 2012 | 22311030 |
| safety and efficacy of rituximab treatment for vasculitis in hepatitis b virus-associated type ii cryoglobulinemia: a case report. | systemic b-cell depletion and clinical remission of the systemic effects of cryoglobulins have already been achieved using rituximab in hepatitis c virus-positive immunocompetent patients. conversely, to the best of our knowledge there are no reports in the literature regarding the use of rituximab in hepatitis b virus-associated cryoglobulinemia. | 2012 | 22284897 |
| hepatitis b virus reactivation during treatment with multi-tyrosine kinase inhibitor for hepatocellular carcinoma. | hepatitis b virus (hbv) reactivation is well documented in individuals with cancer who receive certain cytotoxic or immunosuppressive therapies including rituximab treatment. as a general rule, the risk is greatest upon withdrawal of chemotherapy. the risk ranges from approximately 20 to 50% among hbsag-positive carriers. a 67-year-old man was diagnosed with inoperable multiple hepatocellular carcinoma accompanied by an increase in alpha-fetoprotein and protein induced by vitamin k absence or an ... | 2012 | 23139664 |
| leiomyosarcoma of the adrenal vein. | leiomyosarcoma of the adrenal gland is extremely rare in the literature. we present a patient with an adrenal leiomyosarcoma originating from the adrenal vein, the pathologic findings and management. a 66-year-old man who was a hepatitis b virus carrier was found to have a huge left suprarenal mass on sonography and computed axial tomography. a huge tumor in the left suprarenal area with a markedly engorged adrenal vein was found during an adrenalectomy. the tumor thrombus extended into the rena ... | 2012 | 23127348 |
| extrahepatic portal vein aneurysm after orthotopic liver transplantation: a case with 9-year ultrasound observations. | we report a case of extrahepatic portal vein aneurysm (pva) in the late postoperative period after orthotopic liver transplantation (olt). a 46-year-old man underwent olt in 2001 for treatment of hepatitis b virus-induced cirrhosis and received ultrasound follow-up for 9 years. the long-term ultrasound observations showed that the diameter of the main portal vein had progressively increased from 12 mm in 2001 to 34 mm in 2007, and then remained at 34 mm from 2007 to 2010. the patient did not sho ... | 2012 | 27279116 |
| virus nat for hiv, hbv, and hcv in post-mortal blood specimens over 48 h after death of infected patients - first results. | according to eu regulations (eu directive 2006/17/ec), blood specimens for virologic testing in the context of post-mortal tissue donation must be taken not later than 24 h post mortem. | 2012 | 23801336 |
| [a case of hepatitis b virus/human immunodeficiency virus coinfection in a patient who achived hepatitis b surface antigen seroclearance after interferon therapy followed by antiretroviral therapy without developing immune reconstitution inflammatory syndrome]. | coinfection with human immunodeficiency virus (hiv) and hepatitis b virus (hbv) is common worldwide. the current guidelines for the treatment of hiv infection recommend that hiv patients coinfected with hbv receive antiretoroviral therapy (art) with two nucleoside analogs against hbv. however, an increase in liver enzymes that is usually attributed to hbv immune reconstitution inflammatory syndrome (iris) sometimes occurs in hbv/hiv-coinfected patients after the commencement of art. we report a ... | 2012 | 23367852 |
| [virological breakthrough in treating hepatitis b with entecavir: it means resistance?]. | a 45 year-old married man, with several sexual partners, initiated symptoms with nodosum erythema and in august 2008, is diagnosed of chronic hepatitis due to hepatitis b virus (hbv). later he was diagnosed of child a cirrhosis and hepatocarcinoma. he began hbv treatment with entecavir 0.5 mg; then he underwent a v segment hepatectomy. in february 2009 he presented a relapse with a tumor of 14 mm on vi segment with afp values of 68 ng/dl, so he underwent an ethanolization with good evolution. du ... | 2012 | 23307091 |
| long-term recurrence-free survival after liver transplantation from an abo-incompatible living donor for treatment of hepatocellular carcinoma exceeding milano criteria in a patient with hepatitis b virus cirrhosis: a case report. | the early results of liver transplantations (olt) in patients with advanced hepatocellular carcinoma (hcc) were poor because of frequent tumor recurrence. however, olt has significant, theoretical advantage that it removes both the tumor and the organ that is at a risk of malignancy. the japanese law on organ transplantation limited the availability of cadaveric liver donors until its revision on july 17, 2011. abo-incompatible olt was formerly contraindicated because performed anti-a/b antibodi ... | 2012 | 22410070 |
| the inhibitors of nucleotide biosynthesis leflunomide, fk778, and mycophenolic acid activate hepatitis b virus replication in vitro. | the inhibitors of pyrimidine synthesis leflunomide and fk778 have been reported to exert broad antiviral effects, in addition to their immunosuppressive activities. their possible therapeutic benefit for transplantation medicine is currently discussed, since they also block replication of human cytomegalovirus (cmv) and human polyomavirus bk (bkv) which both cause important complications in transplant recipients. here, we show that leflunomide and fk778 strongly enhance hepatitis b virus (hbv) r ... | 2012 | 22271223 |
| preventing cancer with vaccines: progress in the global control of cancer. | the cancer control community is largely unaware of great advances in the control of major human cancers with vaccines, including the dramatic control of hepatocellular (liver) cancer with hepatitis b virus (hbv) vaccine, now used routinely in more than 90% of countries. the biotechnology revolution has given us a new generation of highly effective vaccines against major global killers, global funding for immunization is orders of magnitude higher than ever before, and the vaccine delivery infras ... | 2012 | 22219163 |
| decrease in size of non-treated lesions after cryoablation for hepatocellular carcinoma. | we present the case of one 58-year-old man with advancd hepatocellular carcinoma and hepatitis-b virus-related liver cirrhosis who received hepatic cryoablation. magnetic resonance imaging (mri) showed multiple liver tumors and the diameter of the largest tumor was more than 10cm. the patient received 2 percutaneous cryoablations in december 2009 and january 2010. ten months later, mri showed that not only the treated areas underwent necrosis but also the non-treated area decreased. the a-fetopr ... | 2012 | 22260835 |
| hepatitis b in the united states: ongoing missed opportunities for hepatitis b vaccination, evidence from the behavioral risk factor surveillance survey, 2007. | purpose: in the usa, the burden of hepatitis b disproportionately affects high-risk adults who alone account for more than 75% of newly reported hepatitis b virus infections each year. despite the localization of new infections in identifiable high-risk groups, vaccination rates in this subgroup, with the exception of health care workers, remain consistently low. the purpose of this study was to characterize those at risk for hepatitis b transmission and quantify the associ ... | 2012 | 22237474 |
| detection of hepatitis b virus in serum and liver of chickens. | abstract: hepatitis b virus (hbv) is one of the most important human pathogens. its existence in food animals could present a significant threat to public health. the objective of this study was to determine if hbv is present in serum and liver of chickens. a total of 129 serum samples from broiler chickens were collected for the detection of hbv antigens and antibodies, and 193 liver samples were tested for hbv dna sequence by pcr and for the existence of hbv antigens by immunohistochemistry. t ... | 2012 | 22217003 |
| Synthesis, stability and pharmacological evaluation of a novel codrug consisting of lamivudine and ursolic acid. | A novel codrug (LMX) was obtained from lamivudine (LMV) and ursolic acid (UA) coupled with ethyl chloroacetate through an amide and ester linkage. The structure of LMX was confirmed by (1)H NMR, (13)C NMR, IR and HRMS. Herein, the in vitro non-enzymatic and enzymatic hydrolysis and in vivo pharmacological activities of LMX were studied. The kinetics of hydrolysis of LMX was studied in aqueous solution of pH 1-10, 80% buffered human plasma and in the presence of lipase from Porcine pancreas (EC 3 ... | 2012 | 22085635 |
| virsirnadb: a curated database of experimentally validated viral sirna/shrna. | rnai technology has been emerging as a potential modality to inhibit viruses during past decade. in literature a few sirna databases have been reported that focus on targeting human and mammalian genes but experimentally validated viral sirna databases are lacking. we have developed virsirnadb, a manually curated database having comprehensive details of 1358 sirna/shrna targeting viral genome regions. further, wherever available, information regarding alternative efficacies of above 300 sirnas d ... | 2012 | 22139916 |
| Hepatitis B Virus Coinfection Negatively Impacts HIV Outcomes in HIV Seroconverters. | (See the editorial commentary by Peters and Marston, on pages 166-8.) Background. Understanding the impact of hepatitis B virus (HBV) in human immunodeficiency virus (HIV) coinfection has been limited by heterogeneity of HIV disease. We evaluated HBV coinfection and HIV-related disease progression in a cohort of HIV seroconverters. Methods. Participants with HIV diagnosis seroconversion window of =3 years and serologically confirmed HBV infection (HB) status were classified at baseline into 4 HB ... | 2012 | 22147794 |
| human hepatitis b viral e antigen and its precursor p20 inhibit t lymphocyte proliferation. | the hepatitis b virus (hbv) precore protein is processed through the secretory pathway directly as hbeag or with the generation of an intermediate (p20). precore gene has been shown to be implicated in viral persistence, but the functions of hbeag and its precursors have not been fully elucidated. we show that the secreted proteins hbeag and p20 interact with t cell surface and alter kit-225 and primary t cells proliferation, a process which may facilitate the establishment of hbv persistence. o ... | 2012 | 22234307 |
| viral infections and human cancers: the legacy of denis burkitt. | denis parsons burkitt was born in 1911, and in the late 1950s, described the disease that has come to be known as burkitt lymphoma based on cases he observed in uganda. subsequently, burkitt lymphoma was recognized as the first human tumour associated with an infectious agent when epstein-barr virus was isolated from samples supplied by burkitt. it is now recognized that over one-quarter of cancers worldwide are tied to infections. notably, liver cancer is linked to hepatitis b virus and hepatit ... | 2012 | 22233526 |
| towards the eradication of hepatitis b in taiwan. | viral hepatitides are important public health problems in humans. the etiologic agents were not identified until 1965, when baruch s. blumberg found the relationship of australia antigen to serum hepatitis. the antigen was found to be the surface antigen of the hepatitis b virus (hbv). this observation launched a new era in the diagnosis, prevention and treatment of hepatitis b. over 15-20 years, the natural history of hbv infection was elucidated, and more importantly, an effective vaccine beca ... | 2012 | 22226055 |
| in this issue. | cover image: the cover is based on a spinal cord histology section taken from a tnfr2(-/-) mouse adoptively transferred with tnfr2(-/-) treg cells prior to immunization with mog(35-55) to induce eae. the section is stained with luxol fast blue to detect demyelination; luxol fast red, which detects inflammatory infiltration, is the counterstain. the image is taken from the article by tsakiri et al. (pp. 403-412) in which it is shown that tnfr2 on non-haematopoietic cells is necessary for treg- ... | 2012 | 22266713 |
| a case of hepatitis b reactivation due to the hepatitis b virus escape mutant in a patient undergoing chemotherapy. | a 62-year-old man had chronic hepatitis b virus (hbv) infection and was diagnosed with liver cirrhosis. at the time of diagnosis the patient's virologic markers were positive for hepatitis b surface antigen (hbsag), antibody to hepatitis b e antigen (anti-hbe) and antibody to hepatitis b core antigen (anti-hbc), while antibody to hepatitis b surface antigen (anti-hbs) and hbv dna were negative. later the patient received chemotherapy for malignancy. however, this was interrupted due to elevated ... | 2012 | 23180290 |
| Viral screening of spent culture media and liquid nitrogen samples of oocytes and embryos from hepatitis B, hepatitis C, and human immunodeficiency virus chronically infected women undergoing in vitro fertilization cycles. | To assess the presence of viral RNA or DNA sequences in spent culture media used after ovum pickup (OPU) or embryo culture and in liquid nitrogen (LN) used for oocyte or embryo vitrification in patients seropositive for human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) undergoing IVF cycles. | 2012 | 22035968 |
| mutational analysis of tumour suppressor gene nf2 in common solid cancers and acute leukaemias. | germline mutation of nf2 gene is a feature of neurofibromatosis type 2 familial cancer syndrome. also, somatic point mutations of nf2 mutation have been reported in tumours originated from nerve structures. a recent study revealed that nf2 gene was mutated in renal cell carcinoma (rcc) as well, suggesting a possibility that nf2 gene might be somatically mutated in other human cancers. the aim of this study was to explore whether nf2 genes are somatically mutated, and contribute to tumorigenesis ... | 2012 | 22081132 |
| hepatitis b virus x (hbx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated hbx transgenic mice. | hepatitis b virus x (hbx) protein is implicated in hepatitis b virus (hbv)-associated liver carcinogenesis. however, it remains unclear whether hbx-expressing hepatic progenitor cells (hpcs) are attributed to liver tumor formation. in this study, by using hbx transgenic mice and a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (ddc)-induced liver injury model, the relationship between hbx expression and tumorigenicity of hpcs was analyzed. compared with control mice, an elevated number of epcam(+) c ... | 2012 | 21932402 |
| identification of the common regulators for hepatocellular carcinoma induced by hepatitis b virus x antigen in a mouse model. | hepatitis b virus x antigen plays an important role in the development of human hepatocellular carcinoma (hcc). the key regulators controlling the temporal downstream gene expression for hcc progression remains unknown. in this study, we took advantage of systems biology approach and analyzed the microarray data of the hbx transgenic mouse as a screening process to identify the differentially expressed genes and applied the software pathway studio to identify potential pathways and regulators in ... | 2012 | 22021908 |
| viral adaptation to host immune responses occurs in chronic hepatitis b virus (hbv) infection, and adaptation is greatest in hbv e antigen-negative disease. | hepatitis b virus (hbv)-specific t-cell responses are important in the natural history of hbv infection. the number of known hbv-specific t-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic hbv infection. we aimed to identify novel hbv t-cell epitopes by examining the relationship between hbv sequence variation and the human leukocyte antigen (hla) type in a large prospective clinic-based cohort of asian patients with chronic hbv infection recruited in austr ... | 2012 | 22072755 |
| interleukin-10 is expressed in hepg2.2.15 cells and regulated by stat1 pathway. | this study investigated the expression profiles of il-10 gene in three human hepatoma cell lines including huh7, hepg2, and hepg2 transfected with a plasmid containing hepatitis b virus (hbv) named hepg2.2.15. rt-pcr analysis demonstrated that il-10 message rna was absent in hepg2 and huh7 cells, whereas it was present in hepg2.2.15 cells, which was consistent with elisa result. furthermore, except for lamivudine other antiviral treatments did not significantly decrease the hbv dna level in hepg ... | 2011 | 22038351 |
| differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages. | acyclic nucleoside phosphonates (anp) are virostatics effective against viruses like hepatitis b virus and human immunodeficiency virus. our previous reports indicated immunomodulatory activities of anp in mouse and human innate immune cells. recently, evidence has increased that hepatocytes may play an active role in immune regulation of the liver homeostasis or injury. in this study we investigated possible immunomodulatory effects of anp on rat hepatocytes and macrophages. nitric oxide (no) p ... | 2011 | 22198073 |
| prevalence of xmrv infection in different risk populations in spain. | human infection with the xenotropic murine leukemia virus-related virus (xmrv) has been associated controversially with prostate cancer and chronic fatigue syndrome. information is lacking about the mechanisms of transmission and potential risk groups for xmrv infection. plasma and peripheral blood mononuclear cells (pbmcs) from individuals with retroviral infections, chronic viral hepatitis, autoimmune diseases, prostate cancer, chronic fatigue syndrome and blood donors were tested for xmrv mar ... | 2011 | 22206583 |
| the characteristics of the synonymous codon usage in hepatitis b virus and the effects of host on the virus in codon usage pattern. | abstract: background: hepatitis b virus (hbv) infection is one of the main human health problem and causes a large-scale of patients chronic infection worldwide.. as the replication of hbv depends on its host cell system, codon usage pattern for the viral gene might be susceptible to two main selections, namely mutation pressure and translation selection. in this case, a deeper investigation between hbv evolution and host adaptive response might assist control this disease. result: relative syn ... | 2011 | 22171933 |
| the role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma. | expression of the polymeric immunoglobulin receptor (pigr), a transporter of polymeric iga and igm, is commonly increased in response to viral or bacterial infections, linking innate and adaptive immunity. abnormal expression of pigr in cancer was also observed, but its clinical relevance remains uncertain. | 2011 | 22025622 |
| Outcomes of renal transplants from Centers for Disease Control and Prevention high-risk donors with prospective recipient viral testing: a single-center experience. | The use of kidneys from deceased donors considered at increased infectious risk represents a strategy to increase the donor pool. | 2011 | 22106317 |
| type i interferon negatively controls plasmacytoid dendritic cell numbers in vivo. | plasmacytoid dendritic cells (pdcs) specialize in the secretion of type i interferons (ifn-i) and thus are considered critical mediators of antiviral responses. we recently reported that pdcs have a very early but limited and transient capacity to curtail viral infections. additionally, pdc numbers are not sustained in human infections caused by hepatitis b or c viruses (hbv and hcv) and hiv. thus, the numbers and/or function of pdcs appear to be regulated during the course of viral infection. i ... | 2011 | 22084408 |
| impact of comorbidities and drug therapy on development of renal impairment in a predominantly african american and hispanic hiv clinic population. | renal impairment in human immunodeficiency virus (hiv)-infected patients could potentially be caused by many factors. hiv-related renal impairment risks have been little studied in african americans and hispanics. we investigated the impact of hiv itself, highly active antiretroviral therapy (haart), comorbidities, and non-hiv-related drug treatment on glomerular filtration rate in a predominantly african american/hispanic hiv-infected population who had received haart for at least one year. thi ... | 2011 | 22096402 |
| factors associated with hepatitis b testing among cambodian american men and women. | cambodian americans have an elevated risk of liver cancer. this health disparity is attributable to high rates of hepatitis b virus (hbv) infection. our study examined factors associated with hbv testing among cambodian men and women. a population-based survey was conducted in the seattle area. the health behavior framework guided our survey instrument development. we attempted to interview a man and a woman in each household. the sample included 300 men and 367 women. about one-half of the male ... | 2011 | 22002705 |
| Silver nanoparticles as potential antiviral agents. | Virus infections pose significant global health challenges, especially in view of the fact that the emergence of resistant viral strains and the adverse side effects associated with prolonged use continue to slow down the application of effective antiviral therapies. This makes imperative the need for the development of safe and potent alternatives to conventional antiviral drugs. In the present scenario, nanoscale materials have emerged as novel antiviral agents for the possibilities offered by ... | 2011 | 22024958 |
| Comparison between Elecsys HBsAg II and Architect HBsAg QT assays for quantification of hepatitis B surface antigen among patients co-infected with HIV and hepatitis B virus. | Hepatitis B surface antigen (HBsAg) quantification has been steadily gaining interest as a clinical marker of therapeutic efficacy, for which currently two commercial assays are available: Architect HBsAg QT (Architect) and Elecsys HBsAg II (Elecsys). HBsAg quantification was evaluated using both assays in 126 human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients initiating treatment with tenofovir dipivoxil fumarate. Linear regression and correlation were used to e ... | 2011 | 22190396 |
| Non-classical MHC-? genes in chronic hepatitis B and hepatocellular carcinoma. | The non-classical human leukocyte antigens (HLA)-E, HLA-G, and HLA-F have been shown to modulate immune responses. We examined whether non-classical HLA polymorphisms are associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Fifteen Single-nucleotide polymorphisms (SNPs) in these non-classical class I alleles were investigated by ligase detection reaction. A fragment of 650 bp located in the 3' untranslated region of HLA-G was investigated. Four SNPs (rs17875380, ... | 2011 | 22015712 |
| hepatitis delta in hiv/hbv co-infected patients in brazil: is it important? | this study was carried out to evaluate the prevalence of hepatitis delta virus (hdv) among human immunodeficiency virus (hiv)/hepatitis b virus (hbv) co-infected patients from são paulo, in the southeast region of brazil. | 2011 | 21999909 |
| Hepatocyte polarization is essential for the productive entry of the hepatitis B virus. | Human hepatitis B virus (HBV) is characterized by a high species specificity and a distinct liver tropism. Within the liver, HBV replication occurs in differentiated and polarized hepatocytes. Accordingly, the in vitro HBV infection of primary human hepatocytes (PHHs) and the human hepatoma cell line, HepaRG, is restricted to differentiated, hepatocyte-like cells. Though preparations of PHH contain up to 100% hepatic cells, cultures of differentiated HepaRG cells are a mixture of hepatocyte-like ... | 2011 | 21953491 |
| Cryo-EM study of Hepatitis B virus core antigen capsids decorated with antibodies from a human patient. | The capsid (core antigen, HBcAg) is one of three major antigens present in patients infected with Hepatitis B virus. The capsids are icosahedral particles, whose most prominent features are spikes that extend 25Å out from the contiguous "floor". At the spike tip are two copies of the "immunodominant loop". Previously, the epitopes of seven murine monoclonal antibodies have been identified by cryo-EM analysis of Fab-labeled capsids. All but one are conformational and all but one map around the sp ... | 2011 | 22056468 |
| The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. | Cytotoxic CD8 T lymphocytes (CTLs) play a pivotal role in the control of infection. Activated CTLs, however, often lose effector function during chronic infection. PD-1 receptor and its ligand PD-L1 of the B7/CD28 family function as a T cell coinhibitory pathway and are emerging as major regulators converting effector CTLs into exhausted CTLs during chronic infection with human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and other pathogens capable of establishing chronic infec ... | 2011 | 21960736 |
| [hepatitis b; sometimes co-infection with hepatitis d]. | the hepatitis delta virus (hdv) is a defect rna virus that requires the presence of the hepatitis b virus (hbv) for cellular infection. worldwide, 350 million people are infected with hbv; 5% of these are superinfected with hdv. a chronic superinfection with hdv has a higher morbidity and mortality rate. it is clinically difficult to differentiate between an hbv and an hdv infection. diagnosis is made via detection of hdv antibodies and hdv-rna using pcr techniques. the only treatment option is ... | 2011 | 21854665 |
| epidemic of hepatitis b with high mortality in india: association of fulminant disease with lack of ccl4 and natural killer t cells. | an explosive outbreak of hepatitis b with high mortality was reported in 2009, in modasa, gujarat, india. mortality was associated with basal core promoter and precore mutant hepatitis b virus (hbv). the current study addresses the role of immunological parameters in the progression to fulminant hepatitis. the study population comprised of 22 acute hbv patients, 13 fulminant hbv liver failure patients and 54 healthy controls. hepatitis b surface antigen-induced ctl responses by enzyme-linked imm ... | 2011 | 21914058 |
| Transplantation of human cells in the peritoneal cavity of immunodeficient mice for rapid assays of hepatitis B virus replication. | Kumar M, Bandi S, Cheng K, Gupta S. Transplantation of human cells in the peritoneal cavity of immunodeficient mice for rapid assays of hepatitis B virus replication. Xenotransplantation 2011; 18: 380-389. © 2011 John Wiley & Sons A/S. Abstract: Background: Studies of natural hepatitis B virus infection must be restricted to humans or primates due to viral species-specificity. Alternative hepadnavirus animal models, e.g., woodchuck hepatitis virus in captive woodchucks, are not convenient, whi ... | 2011 | 22168144 |
| high levels of serum hepatitis b virus dna in patients with 'anti-hbc alone': role of hbsag mutants. | it remains unclear how the detection of hepatitis b core antibody (anti-hbc) in the absence of hepatitis b surface antigen (hbsag) and antibody (anti-hbs) should be interpreted and whether all patients with this pattern need to be tested for hepatitis b virus (hbv)-dna. this study aimed at reassessing the significance of 'anti-hbc alone' in unselected sera referred to the clinical laboratory and determining whether significant hbv viraemia can be found in this setting. of the 6431 patients teste ... | 2011 | 21914087 |
| simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: a case report. | primary hepatic malignant fibrous histiocytoma (mfh) is rarely encountered. there have been no reports to date of hepatic mfh associated with liver cirrhosis. the presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (hcc) in the diagnosis of spindle cell tumors in liver. we describe here a 59-year-old man with liver cirrhosis due to hepatitis b virus infection 20 years ago. on abdominal computed tomography scanning, two distinct hepatic ma ... | 2011 | 21969879 |
| Significant hepatic histopathology in chronic hepatitis B patients with serum ALT less than twice ULN and high HBV-DNA levels in Indonesia. | To study the prevalence of significant hepatic histopathology in chronic hepatitis B (CHB) patients with alanine aminotransferase (ALT) = twice upper limit of normal (ULN) and its association with age, HBeAg status, hepatitis B virus (HBV)-DNA level and viral genotype. | 2011 | 22118698 |
| establishment of a new human pneumococcal standard reference serum, 007sp. | lot 89sf has been the reference standard serum pool used in pneumococcal enzyme-linked immunosorbent assays (elisas) since 1990. in 2005, it was estimated that there remained between 2 and 5 years' supply of lot 89sf. since lot 89sf was the reference standard used in the evaluation of the seven-valent pneumococcal conjugate vaccine prevnar (pcv7), the link to clinical efficacy would be severed if stocks became completely depleted. furthermore, demonstration of immune responses comparable to thos ... | 2011 | 21852547 |
| development of a listeria monocytogenes-based vaccine against hepatocellular carcinoma. | live attenuated listeria monocytogenes (lm) is a promising bacterial vector able to induce a t-cell response to tumor-associated antigens and demonstrates great potential for use in vaccine development. a novel recombinant lm-based vaccine (lmdd (lm δdalδdat)-mpfg (multiple peptide fusing genes)) was developed with the ability to express and secrete hepatocellular carcinoma (hcc)-related tumor-associated antigens fragments due to the insertion of hepatitis b virus (hbv)-x protein (hbx)-derived e ... | 2011 | 21927025 |
| Hepatitis B virus envelope L protein-derived bio-nanocapsules: Mechanisms of cellular attachment and entry into human hepatic cells. | A bio-nanocapsule (BNC) is a hollow nanoparticle consisting of an approximately 100-nm-diameter liposome with about 110 molecules of hepatitis B virus (HBV) surface antigen L protein embedded as a transmembrane protein. BNC can encapsulate various drugs and genes and deliver them specifically to human hepatic cells based on the ability of HBV to recognize human hepatocyte, which is integrated in the N-terminal region of L protein. However, it is elusive whether the cellular attachment and entry ... | 2011 | 22100387 |
| design of therapeutic vaccines: hepatitis b as an example. | therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (hpv), human immunodeficiency virus (hiv), herpesvirus and hepatitis b (hbv) and c (hcv) virus infections. as an alternative to antiviral treatment or to support only partially effective therapy a therapeutic vaccine shall activate the patient's immune system to fight and finally control or ideally even eliminate the virus. whereas the success of prophylactic vaccination is based on rapid neut ... | 2011 | 21958338 |
| [The health conditions of prison inmates in Tuscany]. | Objective: investigation of health conditions of prison inmates inTuscany (Italy) comparedwith non-institutionalized population and literature data. Design: cross-sectional descriptive study of a sample recruited for a prospective cohort study. Setting e participants: prison inmates detained inTuscany on June 15th 2009. Istat data concerning the survey "Aspects of daily life" 2006-2009 has been used for comparison. Main outcome measures: themeasures used for the analysis are prevalence data by a ... | 2011 | 22166776 |
| incarceration is a major risk factor for blood-borne infection among intravenous drug users: incarceration and blood borne infection among intravenous drug users. | there is a strong association between hepatitis b virus (hbv), hepatitis c virus (hcv) and human immunodeficiency virus (hiv) infection which are mainly transmitted by contamination with blood via intravenous drug abuse (ivdu) or sexual contact. | 2011 | 22087111 |
| The Management of Blood Safety in the Presence of Uncertain Risk: A United Kingdom Perspective. | Millions of patients in the UK benefit from the use of both plasma derivatives and blood components that are seen as critical interventions in current medicine. Measures are in place to significantly reduce the risks associated with blood transfusion and plasma derivatives; however, these measures themselves are not risk free. Over the past 20 years, advances in technology and regulation have seen major reductions in the risks associated with transfusion. International blood services, industry, ... | 2011 | 22126710 |
| Human immunodeficiency virus and liver disease forum 2010: Conference proceedings. | Liver disease continues to represent a critical mediator of morbidity and mortality in those with human immunodeficiency virus (HIV) infection. The frequent presence and overlap of concomitant injurious processes, including hepatitis C virus and hepatitis B virus infections, hepatoxicity associated with antiretroviral therapeutic agents, alcohol, and other toxins, in the setting of immunosuppression lead to rapid fibrotic progression and early development of end-stage liver disease. This confere ... | 2011 | 21898501 |
| Occult hepatitis B virus infection: A major concern in HIV-infected patients: Occult HBV in HIV. | Human immunodeficiency virus (HIV)- infected patients are at risk of acquiring viral hepatitis, due to common routes of transmission. As the introduction of highly active antiretroviral therapy (HAART) reduced the frequency of opportunistic infections and improved survival, viral hepatitis emerged as an important cause of morbidity and mortality in HIV-infected cases. Occult hepatitis B virus (HBV) infection is characterized by presence of HBV infection without detectable hepatitis B surface ant ... | 2011 | 22087108 |
| current concept in the pathophysiology of hepatitis delta infection. | hepatitis delta virus (hdv) is a unique human virus, showing similarities with plant viroids. although impressive knowledge on virus structure and replication has been achieved, several questions like hbv/hdv interaction and post translational modifications of hd antigens remain to be answered. potential targets for therapeutic strategies are now emerging. to date, eight major genotypes of the hdv have been identified. the hdv-1 is the prevailing genotype in europe, but migration phenomena may c ... | 2011 | 22161240 |
| anti-hepatitis b virus and cytotoxic diterpenoids from isodon lophanthoides var. gerardianus. | four new diterpenoides, isolophanthins a-d (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from isodon lophanthoides var. gerardianus. the new diterpenoides were elucidated by spectroscopic analysis. some of them showed significant activities against hbsag and hbeag of hepatitis b virus in hep g 2.2.15 cells, as well as the human tumor cell lines, hl-60, a-549, molt-4, and bel-7402. | 2011 | 21881252 |
| lack of association of rad51 genetic variations with hepatitis b virus clearance and occurrence of hepatocellular carcinoma in a korean population. | the reca homolog, e. coli (s. cerevisiae) (rad51) may modulate hepatitis b virus (hbv) infection by maintaining genome integrity and mediating homologous dna repairs. in this study, 16 sequence variations were detected by resequencing all exons, the exon-intron boundary, and promoter regions of the human rad51 gene in dna samples of 24 unrelated individuals. to investigate the association of common variations in the rad51 locus with hbv infection and hepatocellular carcinoma (hcc) occurrence, si ... | 2011 | 21915862 |
| infectivity of pre-seroconversion donations: an analysis of lookback exercises in the netherlands, 2000-2006. | background and objectives blood can be infectious if it is donated shortly before infection with hepatitis b virus (hbv), hepatitis c virus (hcv) or human immunodeficiency virus (hiv) becomes detectable. lookback exercises may detect infection in recipients of pre-seroconversion donations. this study provides an analysis of the dutch lookback exercises in the years 2000 through 2006. materials and methods all lookback procedures, triggered by 50 repeat donors seroconverting for hbv (n = 32), h ... | 2011 | 21883273 |
| virus-like particles: potential veterinary vaccine immunogens. | virus-like particle (vlp) composed of outer shell but no genome of virus mimics the natural configuration of authentic virion and has no characteristics of self-replication. a close resemblance to native viruses in molecular scaffolds and an absence of genomes make vlps effectively elicit both humoral and cell-mediated immune responses even with no requirement of adjuvant for vaccines. as effective immunogens, characterized by high immunogenicity and safety, vlps have been employed in production ... | 2011 | 22100244 |
| a case of cutaneous infection caused by mycobacterium szulgai with progression to acute respiratory distress syndrome. | a 59-year-old man presented with a skin eruption and bilateral swelling of the legs. soon after the initial presentation, he developed acute respiratory distress syndrome (ards) with miliary lung nodules. culture of samples from the skin ulcers, sputum, and bronchoalveolar lavage fluid all revealed mycobacterium szulgai infection. the patient was successfully treated with antituberculosis drugs. m. szulgai infection is very rarely reported worldwide, and disseminated infection usually occurs in ... | 2011 | 22084610 |
| serum paraoxonase and arylesterase activities in various forms of hepatitis b virus infection. | the aim of this study was to determine and evaluate the activity of paraoxonase and arylesterase enzymes in various clinical forms of hepatitis b infection and to investigate the correlation between these parameters and chronic disease course/fibrosis. overall, 40 patients diagnosed as hepatitis b carriers (cihbv), 40 chronic active hepatitis b (cahbv) patients, and 40 healthy adults (control group) between 18 and 65 years of age were enrolled the study. serum paraoxonase and arylesterase activi ... | 2011 | 21919063 |
| Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential. | Antiviral compounds that increase the resistance of host tissues represent an attractive class of therapeutic. Here, we show that squalamine, a compound previously isolated from the tissues of the dogfish shark (Squalus acanthias) and the sea lamprey (Petromyzon marinus), exhibits broad-spectrum antiviral activity against human pathogens, which were studied in vitro as well as in vivo. Both RNA- and DNA-enveloped viruses are shown to be susceptible. The proposed mechanism involves the capacity o ... | 2011 | 21930925 |
| [Epidemiology of viral hepatitis in Mexico]. | The main etiology of liver disease in Mexico is alcohol and viral hepatitis. The aim of the present study was to analyze the current epidemiology of viral hepatitis in Mexico. From 2000 to 2007 the Ministry of Health reported 192 588 cases of hepatitis, 79% HAV, 3.3% HBV, 6% HCV, and 12% without a specific etiologic factor. Due to high endemic areas for HBV infection in native Mexican population, limitations in the diagnostic sensitivity and specificity of the serological immunoassays used to da ... | 2011 | 21877071 |
| the immunophilin-like protein xap2 is a negative regulator of estrogen signaling through interaction with estrogen receptor α. | xap2 (also known as aryl hydrocarbon receptor interacting protein, aip) is originally identified as a negative regulator of the hepatitis b virus x-associated protein. recent studies have expanded the range of xap2 client proteins to include the nuclear receptor family of transcription factors. in this study, we show that xap2 is recruited to the promoter of erα regulated genes like the breast cancer marker gene ps2 or greb1 and negatively regulate the expression of these genes in mcf-7 cells. i ... | 2011 | 21984905 |
| The influence of HLA alleles and HBV subgenotyes on the outcomes of HBV infections in Northeast China. | Hepatitis B virus (HBV) infection has a wide variety of clinical outcomes, it could be spontaneouly recovered and also could develop fulminant liver failure or cirrhosis with hepatocellular carcinoma. Human leukocyte antigen (HLA) polymorphism and HBV (sub)genotypes have been speculated to associate with the outcome of HBV infection because the data obtained from various populations who bear different HLA alleles have shown a HLA polymorphism associated outcome of HBV infection. However, as the ... | 2011 | 22056847 |
| Molecular characterization of hepatitis B virus strains circulating in Belgian patients co-infected with HIV and HBV: overt and occult infection. | Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) have similar transmission routes, implying that patients infected with HIV are at particular risk for HBV infection. Patients who are co-infected with HIV and HBV progress more rapidly to end-stage liver disease and different HBV genotypes may have a distinct impact on disease progression. One hundred ninety-one anti-HBc-positive sera from Belgian patients co-infected with HIV and HBV were collected during 1998-2008. Full-length HBV ... | 2011 | 21915860 |
| Infections in hemodialysis: a concise review. Part II: blood transmitted viral infections. | Hemodialysis (HD) patients are particularly predisposed to infections. It seems that the HD procedure per se as well as disturbances in both innate and adaptive immunity significantly contribute to this susceptibility. Infections are the major cause of morbidity and the second cause of death following cardiovascular events in HD patients. Episodes of bacteremia and pneumonia account for the majority of severe infections in this population. In addition to these bacterial infections another common ... | 2011 | 22110292 |
| a liver-specific microrna binds to a highly conserved rna sequence of hepatitis b virus and negatively regulates viral gene expression and replication. | regulated gene expression and progeny production are essential for persistent and chronic infection by human pathogens, such as hepatitis b virus (hbv), which affects >400 million people worldwide and is a major cause of liver disease. in this study, we provide the first direct evidence that a liver-specific microrna, mir-122, binds to a highly conserved hbv pregenomic rna sequence via base-pairing interactions and inhibits hbv gene expression and replication. the mir-122 target sequence is loca ... | 2011 | 21903935 |
| Hepatitis B virus infection and replication in human bone marrow mesenchymal stem cells. | ABSTRACT: | 2011 | 22035170 |
| [Human immunodeficiency virus infection and viral hepatitis]. | Hepatic complications currently represent one of the leading reasons for medical consultations, hospitalisation, and death in the HIV-infected population. This is due to a large extent to viral hepatitis, given its disproportionate frequency in this population. Chronic hepatitis B affects 5-10% of the HIV-infected population. Vaccination has reduced the incidence of liver disease related to hepatitis-B virus (HBV), and the availability of tenofovir has dramatically improved the prognosis of HIV/ ... | 2011 | 21978797 |
| Demographics of apheresis platelet donors in five blood centers in China. | BACKGROUND: Blood component donations by apheresis has become more common in modern blood transfusion practices. However, apheresis donation still remains less common in China. This study describes the demographic profile and transfusion-transmissible infection (TTI) prevalence among donors making apheresis platelet (AP) donations compared to those making whole blood (WB) donations and the differences among five geographically diverse blood centers in China. STUDY DESIGN AND METHODS: This is a d ... | 2011 | 21895674 |
| splenic marginal zone b-cell lymphoma with epidermotropic skin involvement. | marginal zone b-cell lymphoma (mzl) is subclassified into extranodal mzl of mucosa-associated lymphoid tissue (including cutaneous lymphomas), splenic mzl, and nodal mzl. we report the case of a 68-year-old man with erythematous-violaceous plaques and nodules. skin biopsy showed an epidermotropic lymphocytic infiltration and cytology and immunohistochemistry were consistent with mzl. the workup revealed disease in the peripheral blood and bone marrow and massive splenomegaly. splenectomy confirm ... | 2011 | 21885023 |
| immune control of hepatitis b virus. | human hepatitis b virus (hbv) infects the liver of humans or humanoid primates. in humans, hbv infection often causes an inflammatory liver disease - hepatitis b. the virus is transmitted by perinatal, percutaneous and sexual exposure, as well as by close person-to-person contact. the latter occurs especially among young children, presumably by open cuts or sores. vertical transmission from mothers to their neonates, or infection during the first year of life, results in persistent often lifelon ... | 2011 | 21894014 |
| Vaccination with m2e-based multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice. | The extracellular domain of the influenza A virus protein matrix protein 2 (M2e) is remarkably conserved between various human isolates and thus is a viable target antigen for a universal influenza vaccine. With the goal of inducing protection in multiple mouse haplotypes, M2e-based multiple antigenic peptides (M2e-MAP) were synthesized to contain promiscuous T helper determinants from the Plasmodium falciparum circumsporozoite protein, the hepatitis B virus antigen and the influenza virus hemag ... | 2011 | 22180783 |
| [Effects of miR-122 on expression of hepatitis B virus proteins]. | Objective: To investigate the effect of miR-122 on the expression of hepatitis B virus (HBV) proteins. Methods: Anti-sense oligodeoxynucleotide (ASODN) of two different sequences against miR-122, anti-miR-122 and LNA-antimiR-122 (Locked nucleic acid), human miR -122 (hsa-miR-122), or the negative control anti-GFP were designed and synthesized, then transfected into HepG2.2.15 cells. After 24 h and 48 h, the levels of HBsAg and HBeAg in the supernatant were determined with a time-resolved immunof ... | 2011 | 22190518 |
| display of the antigenic region of nipah virus nucleocapsid protein on hepatitis b virus capsid. | the c-terminal domain of nipah virus (niv) nucleocapsid protein (np(401-532)) was inserted at the n-terminus and the immunodominant loop of hepatitis b core antigen (hbc). the stability of np(401-532) increased tremendously when displayed on the hbc particles. these particles reacted specifically with the swine anti-niv and the human anti-hbc antisera. | 2011 | 22024533 |
| Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma. | The programmed cell death-1 receptor/programmed cell death-1 ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1/PD-1 and prognosis after cryoablation in patients with HBV-related hepatocellular carcinoma (HCC). | 2011 | 21912640 |
| Baseline CD4+ T lymphocyte cell counts, hepatitis B and C viruses seropositivity in adults with Human Immunodeficiency Virus infection at a tertiary hospital in Nigeria. | Ekiti State of Nigeria is known to have the lowest prevalence of HIV in Nigeria. University Teaching Hospital (UTH), Ado Ekiti was recently upgraded to serve as one of the three centres for HIV/AIDS referral, diagnosis and treatment in Ekiti State. We evaluated the baseline immunologic and biochemical parameters of patients presenting at the ART clinic of University Teaching Hospital, Ado Ekiti, Ekiti State. | 2011 | 22145054 |
| Molecular analysis of hepatitis B virus (HBV) in an HIV co-infected patient with reactivation of occult HBV infection following discontinuation of lamivudine-including antiretroviral therapy. | ABSTRACT: | 2011 | 22054111 |
| [inhibitory effect of recombinant hmgn2 protein on human hepatitis b viral]. | to construct a prokaryotic expression recombinant for the expression of hmgn2 and to evaluate its antiviral activity against human hepatitis virus. | 2011 | 21866626 |
| ficolin-2 levels and fcn2 haplotypes influence hepatitis b infection outcome in vietnamese patients. | human ficolin-2 (l-ficolins) encoded by fcn2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver. ficolin-2 serum levels and fcn2 single nucleotide polymorphisms were associated to several infectious diseases. we initially screened the complete fcn2 gene in 48 healthy individuals of vietnamese ethnicity. we genotyped a vietnamese cohort comprising of 423 clinically classified hepatitis b virus patients and 303 controls for function ... | 2011 | 22140517 |