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recommendations for outpatient parenteral antimicrobial therapy in brazil.a panel of national experts was convened by the brazilian infectious diseases society in order to determine the recommendations for outpatient parenteral antimicrobial therapy (opat) in brazil. the following aspects are covered in the document: organization of opat programs; patient evaluation and eligibility criteria, including clinical and sociocultural factors; diagnosis of eligibility; venous access and antimicrobial infusion devices; protocols for antimicrobial use and monitoring and cost-e ...201828711455
finite element analysis of bone stress in the posterior mandible using regular and short implants, in the same context, with splinted and nonsplinted prostheses.the aim of this study was to compare the bone stress generated by rehabilitation using regular and short-length morse taper implants (11 and 5 mm, respectively) in the same context and allied with splinted (sp) and nonsplinted (nsp) prostheses in the posterior area of the mandible using finite element analysis.201828708912
15-deoxy-isoxeniolide-a, new diterpenoid from a bornean soft coral, xenia sp.a new xenicane diterpenoid, 15-deoxy-isoxeniolide-a (1) along with four known compounds 9-deoxy-isoxeniolide-a (2), isoxeniolide-a (3), xeniolide-a (4) and coraxeniolide-b (5) were isolated from the bornean soft coral xenia sp. the structures of these metabolites were elucidated on the basis of spectral analysis, nmr and hresims. compound 5 showed cytotoxic activity against atl cell line, s1t.201828691521
incremental diagnostic value of targeted biopsy using mpmri-trus fusion versus 14-fragments prostatic biopsy: a prospective controlled study.to compare the incremental diagnostic value of targeted biopsy using real-time multiparametric magnetic resonance imaging and transrectal ultrasound (mpmri-trus) fusion to conventional 14-cores biopsy.201828687911
a genomic perspective on hla evolution.several decades of research have convincingly shown that classical human leukocyte antigen (hla) loci bear signatures of natural selection. despite this conclusion, many questions remain regarding the type of selective regime acting on these loci, the time frame at which selection acts, and the functional connections between genetic variability and natural selection. in this review, we argue that genomic datasets, in particular those generated by next-generation sequencing (ngs) at the populatio ...201828687858
flow-diverting stent in the treatment of cervical carotid dissection and pseudoaneurysm: review of literature and case report.the endovascular technique has been recommended over the past few years to extracranial carotid dissection and pseudoaneurysm with promising results, especially after medical therapy failure. flow-diverting stents are an alternative for complex cases. these stents have proven to be effective treatment devices for intracranial aneurysms.201828689955
comparison between inflammation-related markers in peri-implant crevicular fluid and clinical parameters during osseointegration in edentulous jaws.the aim of this study is to improve the understanding of interleukin mechanisms during osseointegration to enhance the monitoring of implant failure and success. clinical parameters, implant stability, and cytokine levels in peri-implant crevicular fluid (picf) during early bone healing after implant placement were investigated.201828710652
exclusive gut flagellates of serritermitidae suggest a major transfaunation event in lower termites: description of heliconympha glossotermitis gen. nov. spec. nov.the guts of lower termites are inhabited by host-specific consortia of cellulose-digesting flagellate protists. in this first investigation of the symbionts of the family serritermitidae, we found that glossotermes oculatus and serritermes serrifer each harbor similar parabasalid morphotypes: large pseudotrichonympha-like cells, medium-sized leptospironympha-like cells with spiraled bands of flagella, and small hexamastix-like cells; oxymonadid flagellates were absent. despite their morphologica ...201828682523
improved transoral dissection of the tongue base with a next-generation robotic surgical system.to describe the application of a novel, flexible, single-port robotic surgical system for transoral tongue base resection, and compare it to the current multiport, rigid-arm robotic surgical system.201828681924
comparative rna-sequencing analysis of er-based hsp90 functions and signal pathways in tribolium castaneum.tribolium castaneum, the red flour beetle, is a major agriculture pest that damages stored grains and cereal products. heat-shock protein 90 of t. castaneum (tchsp90) has been reported to play pivotal roles in heat stress response, development, reproduction, and life span. however, the signaling pathway of tchsp90 remains unclear. thus, the global transcriptome profiles between rna interference (rnai)-treated insects (ds-tchsp90) and control insects of t. castaneum were investigated and compared ...201828681272
use of leukocyte- and platelet-rich fibrin in the treatment of medication-related osteonecrosis of the jaws.lesions associated with medication-related osteonecrosis of the jaws (mronj) are refractory to different treatment approaches. hence, auxiliary approaches capable of improving patient outcomes should be explored. leukocyte- and platelet-rich fibrin (lprf) is a second-generation platelet concentrate (natural autologous fibrin matrix). it shows anti-infectious activity through immune regulation and accelerates the angiogenesis and multiplication of fibroblasts and osteoblasts; in consequence, it s ...201828675810
isolation and structure determination of a new diketopiperazine dimer from marine-derived fungus aspergillus sp. sf-5280.a new diketopiperazine dimer designated as sf5280-415 (1) was isolated from an etoac extract of the marine-derived fungus aspergillus sp. sf-5280 by various chromatographic methods. the structure of 1 was mainly determined by analysis of the nmr spectroscopic data and ms data, along with marfey's method. this compound is a new diastereoisomer of known bispyrrolidinoindoline diketopiperazine alkaloid win 64745, which possesses unique architecture biosynthetically derived from an indole oxidation ...201828670919
t-piece versus self-inflating bag ventilation in preterm neonates at birth.to verify whether the use of the t-piece resuscitator compared with the self-inflating bag in preterm infants ventilated at birth modifies survival to hospital discharge without major morbidities.201828663283
n-hydroxymethylglycinate with edta is an efficient eye drop preservative with very low toxicity: an in vitro comparative study.preservatives are used in multi-dose ophthalmic topical medications in order to prevent contamination by bacteria and fungi. however, prolonged use of preserved eye drops, as it may happen in dry eye or glaucoma, may damage cells of the ocular surface. therefore, an important goal is to find preservatives with low toxicity which are mild to host cells, still able to prevent drug contamination so to maintain their sterility and efficacy. hence, aim of this study has been to compare the relative t ...201828658977
evaluation of the dynamics of microalgae population structure and process performance during piggery wastewater treatment in algal-bacterial photobioreactors.the dynamics of microalgae population during piggery wastewater (pww) treatment in four open photobioreactors operated at 27days of hydraulic retention time, and inoculated with chlorella sp. (r1), acutodesmus obliquus (r2), oscillatoria sp. (r3) and in the absence of inoculum (r4), were evaluated for 6months. in addition, the algal-bacterial biomass concentration, removal of organic matter, nutrients and heavy metals were also assessed. the results revealed a high diversity and rapid variations ...201828651871
septicaemia caused by elizabethkingia-sp in a 'healthy' sri lankan man. 201828641481
variation of synechococcus pigment genetic diversity along two turbidity gradients in the china seas.synechococcus are important and widely distributed picocyanobacteria that encompass a high pigment diversity. in this study, we developed a primer set (pebf/pear) for amplifying the cpeba operon sequence from synechococcus genomic dna to study synechococcus pigment diversity along two turbidity gradients in the china seas. our data revealed that all previously reported pigment types occurred in the south (scs) and east (ecs) china seas. in addition, a novel pigment genetic type (type 3f), repres ...201828667427
an update on minding the gap in cancer.this article is a report of the "international colloquium on gap junctions: 50years of impact on cancer" that was held 8-9 september 2016, at the amphitheater "pôle biologie santé" of the university of poitiers (poitiers, france). the colloquium was organized by m mesnil (université de poitiers, poitiers, france) and c naus (university of british columbia, vancouver, canada) to celebrate the 50th anniversary of the seminal work published in 1966 by loewenstein and kanno [intercellular communicat ...201828655619
histopathological changes on the gills of asp (aspius aspius) and european catfish (silurus glanis) caused by lamproglena pulchella and a lamproglena sp. (copepoda: lernaeidae), respectively.in a parasitology survey of hungarian fishes, heavy infections of parasitic copepods lamproglena pulchella and a lamproglena sp. were found in the gills of the asp and the european catfish, respectively. individuals of both fish species were emaciated and infected with hundreds of lamproglena. copepods located close to the tip of gill filaments and formed a depression at the attachment sites. in histological sections, cell degenerations and local haemorrhages were present adjacent to the maxilli ...201828677150
the role of armc5 in human cell cultures from nodules of primary macronodular adrenocortical hyperplasia (pmah).the participation of aberrant receptors and intra-adrenal acth in hyperplastic tissue are considered mechanisms that regulate hypercortisolism in pmah. additionally, germline armc5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with pmah. previous functional studies analyzed armc5 role using h295r cells. therefore, we investigated the role of armc5 in cell cultures obtained from pmah nodules containing steroidogenic cells, aberrant receptors an ...201828676429
intra-articular injection of a substance p inhibitor affects gene expression in a joint contracture model.substance p (sp), a neurotransmitter released after injury, has been linked to deregulated tissue repair and fibrosis in musculoskeletal tissues and other organs. although sp inhibition is an effective treatment for nausea, it has not been previously considered as an anti-fibrotic therapy. although there are extensive medical records of individuals who have used sp antagonists, our analysis of human registry data revealed that patients receiving these antagonists and arthroplasty are exceedingly ...201828671282
analysis of the posture pattern during robotic simulator tasks using an optical motion capture system.surgeons are sometimes forced to maintain uncomfortable joint positions during robotic surgery despite the high degree of instrument maneuverability. this study aimed to use an optical motion capture system to analyze the differences in posture patterns during robotic simulator tasks between surgeons at two skill levels.201828664432
food deprivation in f0 generation and hypercaloric diet in f1 generation reduce f2 generation astrogliosis in several brain areas after immune challenge.the effects of maternal food restriction during gestation in f0 generation followed by hypercaloric diet (hd) during puberty in f1 generation (f1hd) were investigated on astrocyte behavior of f2 generation. also, the astrocyte behavior, after an immune challenge, was examined by the immunohistochemical expression of glial fibrillary acidic protein (gfap) in several brain areas.201828641987
a comparison of two clinical scores for bronchiolitis. a multicentre and prospective study conducted in hospitalised infants.there are a number of clinical scores for bronchiolitis but none of them are firmly recommended in the guidelines.201828629673
female double incontinence: prevalence, incidence, and risk factors from the sabe (health, wellbeing and aging) study.double incontinence (di) is incontinence of urine and stool and is an extreme manifestation of pelvic floor dysfunction. the objective of this study was to estimate the prevalence and incidence of di and the risk factors in elderly women in são paulo, brazil.201828620790
caries treatment decisions among undergraduate and postgraduate students supported by visual detection systems.the difficulties of caries diagnosis and the level of examiner's experience may influence the treatment decision, resulting excessive and inefficient intervention.201828627737
retinopathy diabetic screening by non-mydriatic retinography: concordance between primary care physicians, nurses and ophthalmologists.to compare the evaluation of retinographies by a teleophthalmology nurse and primary care physicians (pcp) with an ophthalmologist referral hospital (gold standard).201828624248
transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (macvia-aria) - eip on aha twinning reference site (gard research demonstration project).the overarching goals of the european innovation partnership on active and healthy ageing (eip on aha) are to enable european citizens to lead healthy, active and independent lives whilst ageing. the eip on aha includes 74 reference sites. the aim of this study was to transfer innovation from an app developed by the macvia-france eip on aha reference site (allergy diary) to other reference sites. the phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will ...201828600902
three new polyketides from the marine sponge-derived fungus trichoderma sp. scsio41004.three new polyketides named trichbenzoisochromen a (1), 5,7-dihydroxy-3-methyl -2-(2-oxopropyl)naphthalene-1,4-dione (2) and 7-acetyl-1,3,6-trihydroxyanthracene-9,10- dione (3) together with six known compounds (4-9) were isolated from a sponge-derived fungus trichoderma sp. scsio41004. the structures of three new polyketides (1-3) were determined by the extensive spectroscopic analysis, including 1d, 2d nmr and hresims data. the absolute configuration of compound 1 was confirmed by the specific ...201828592143
surfactant proteins-a and -d attenuate lps-induced apoptosis in primary intestinal epithelial cells (iecs).sp-a/d ko mice with sepsis demonstrate more severe lung, kidney, and gut injury/apoptosis than wt controls. we hypothesize sp-a and sp-d directly regulate lipopolysaccharide (lps)-induced p38 mitogen-activated protein kinase (mapk) activation and gut apoptosis during sepsis.201828591009
single port laparoscopic ileocaecal resection for crohn's disease: a multicentre comparison with multi-port laparoscopy.single port (sp) ileocaecal resection (icr) is an established technique but there are no large studies comparing sp and multi-port (mp) laparoscopic surgery in crohn's disease (cd). the aim of this study was to compare postoperative pain scores and analgesia requirements after sp and mp laparoscopic icr for cd.201828622435
application of a novel phyco-composite biosorbent for the biotreatment of aqueous medium polluted with manganese ions.a composite phyco-biomass including four different marine macroalgae species (chaetomorpha sp., polysiphonia sp., ulva sp., and cystoseira sp.) was evaluated as a novel biosorbent for the biosorption of manganese ions from aqueous solution. the experimental studies were performed to optimize the operational factors including solution ph, biosorbent amount, initial manganese concentration, and reaction time in a batch-mode biosorption system. the removal yield of the biosorbent for manganese ions ...201828621546
effect of uv-b radiation and desiccation stress on photoprotective compounds accumulation in marine leptolyngbya sp.increased awareness regarding the harmful effects of ultraviolet (uv)-b radiation has led to the search for new sources of natural uv-b protecting compounds. mycosporine-like amino acids are one of such promising compounds found in several organisms. cyanobacteria are ideal organisms for isolation of these compounds due to their compatibility and adaptability to thrive under harsh environmental conditions. in the following investigation, we report the production of shinorine in leptolyngbya sp. ...201828584967
enhanced immunization techniques to obtain highly specific monoclonal antibodies.despite fast advances in genomics and proteomics, monoclonal antibodies (mabs) are still a valuable tool for areas such as the evolution of basic research in stem cells and cancer, for immunophenotyping cell populations, diagnosing and prognosis of diseases, and for immunotherapy. to summarize different subtractive immunization approaches successfully used for the production of highly specific antibodies, we identified scientific articles in ncbi pubmed using the following search terms: subtract ...201828581886
a cross-sectional study of the catheter management of neurogenic bladder after traumatic spinal cord injury.this cross-sectional study describes the catheter management of neurogenic bladder (ngb) in patients with traumatic spinal cord injury (tsci) with emphasis on the motivations behind transitions between intermittent (ic) and indwelling catheters.201828580635
biological traits and the complex of parasitoids of the elm pest orchestes steppensis (coleoptera: curculionidae) in xinjiang, china.the flee-weevil orchestes steppensis korotyaev (coleoptera: curculionidae) is a steppe eastern palaearctic species, notable as a serious pest of elms (ulmus spp., ulmaceae), by feeding on the leaves (adults) or mining them heavily (larvae), especially of ulmus pumila l. in xinjiang, china. we have corrected the previous misidentifications of this weevil in china as o. alni (l.) or o. mutabilis boheman and demonstrated that it is likely to be an invasive species in xinjiang. prior to this study, ...201828578717
microbial interactions during sugar cane must fermentation for bioethanol production: does quorum sensing play a role?microbial interactions represent important modulatory role in the dynamics of biological processes. during bioethanol production from sugar cane must, the presence of lactic acid bacteria (lab) and wild yeasts is inevitable as they originate from the raw material and industrial environment. increasing the concentration of ethanol, organic acids, and other extracellular metabolites in the fermentation must are revealed as wise strategies for survival by certain microorganisms. despite this, the c ...201828574287
socioeconomic inequality in preterm birth in four brazilian birth cohort studies.to analyze economic inequality (absolute and relative) due to family income in relation to the occurrence of preterm births in southern brazil.201828572019
randomized clinical study on the analgesic effect of local infiltration versus spinal block for hemorrhoidectomy.postoperative analgesia and early recovery are important for hospital discharge. the primary objective of this study was to compare the analgesic effectiveness of perianal infiltration and subarachnoid anesthesia for hemorrhoidectomy. the secondary objective was to compare time to discharge, adverse effects and complications.201828562733
an analytical gc-ms method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies.microemulsions (mes) loaded with methyl dihydrojasmonate (mj) were developed to improve the aqueous solubility of this drug. the composition of the formulations ranged according to the oil/surfactant ratio (o/s). the mes were characterized according to diameter of droplets, x-ray diffraction and polarized light microscopy. the mj identification and quantification was performed by gas chromatography-mass spectrometry (gc-ms). the mj showed a retention time of ∼16.7 min for all samples. the obtain ...201828565943
stem cell contributions to neurological disease modeling and personalized medicine.human induced pluripotent stem cells (ipscs) represent a revolutionary tool for disease modeling and drug discovery. the generation of tissue-relevant cell types exhibiting a patient's genetic and molecular background offers the ability to develop individual and effective therapies. in this review, we present some major achievements in the neuroscience field using ipscs and discuss promising perspectives in personalized medicine. in addition to disease modeling, the understanding of the cellular ...201828576415
safety, pharmacokinetic, and clinical activity profiles of ramucirumab in combination with three platinum/fluoropyrimidine doublets in japanese patients with chemotherapy-naïve metastatic gastric/gastroesophageal junction cancer.we evaluated the safety, tolerability, pharmacokinetics, and tumor response of ramucirumab in combination with one of three platinum/fluoropyrimidine regimens in japanese patients with chemotherapy-naïve metastatic gastric/gastroesophageal junction cancer.201828667466
enhanced atrazine removal by hydrophyte-bacterium associations and in vitro screening of the isolates for their plant growth-promoting potential.emergent hydrophytes acorus calamus, typha latifolia, and phragmites karka and epiphytic root bacteria isolated from their rhizoplanes were exposed to atrazine (5 and 10 mg l-1) individually and in plant-bacterium combination for 15 days hydroponically. it was observed that a. calamus-pseudomonas sp. strain, the acb combination, was best in decontamination, showing 91% and 87% removal of 5 and 10 mg l-1 atrazine. plant-bacterium association led to significant increase in atrazine decontamination ...201828598215
the sex disparity in risky driving: a survey of colombian young drivers.the overrepresentation of young drivers in poor road safety outcomes has long been recognized as a global road safety issue. in addition, the overrepresentation of males in crash statistics has been recognized as a pervasive young driver problem. though progress in road safety evidenced as a stabilization and/or reduction in poor road safety outcomes has been made in developed nations, less-developed nations contribute the greatest road safety trauma, and developing nations such as colombia cont ...201828548584
morphology and phylogeny of two novel ciliates, arcanisutura chongmingensis n. gen., n. sp. and naxella paralucida n. sp. from shanghai, china.the morphologies of two novel ciliates, arcanisutura chongmingensis n. gen., n. sp. and naxella paralucida n. sp., collected from shanghai, china, have been investigated using live observation and silver staining methods. arcanisutura n. gen. can be easily distinguished from related genera by its inconspicuous, oblique anterior suture. arcanisutura chongmingensis n. sp. is mainly recognized by its elongated body with a tail-like posterior end, 25-33 somatic kineties, and 4-11 excretory pores. na ...201828544006
effect of ultrasonic and sonic activation of root canal sealers on the push-out bond strength and interfacial adaptation to root canal dentine.to evaluate the effect of ultrasonic and sonic activation of two root canal sealers on interfacial adaptation and push-out bond strength (bs) to root canal dentine.201828543092
cereal bars produced with banana peel flour: evaluation of acceptability and sensory profile.a mixture design was used to investigate the effects of banana peel flour, rice flakes and oat flour on sensory acceptability of cereal bars, with subsequent evaluation of sensory profile of products identified as having high acceptability.201828543033
metalloproteomics approach to analyze mercury in breast milk and hair samples of lactating women in communities of the amazon basin, brazil.mercury is a potentially toxic element that is present in the environment of the brazilian amazon and is responsible for adverse health effects in humans. this study sought to assess possible protein biomarkers of mercury exposure in breast milk samples from lactating women in the madeira and negro rivers in the brazilian amazon. the mercury content of hair samples of lactating women was determined, and the proteome of breast milk samples was obtained using two-dimensional electrophoresis after ...201828547667
effects that passive cycling exercise have on muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients: a randomized clinical trial.to evaluate the effects that passive cycling exercise, in combination with conventional physical therapy, have on peripheral muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients admitted to the icu of a tertiary care university hospital.201828538781
mitochondria-rich cells changes induced by nitrite exposure in tambaqui (colossoma macropomum cuvier, 1818).the gill mitochondria-rich cells of the juvenile amazonian fish colossoma macropomum were analyzed using light and scanning and transmission electron microscopy after 96 h exposure to 0.04 and 0.2 mm nitrite. although the number of mitochondria-rich cells decreased significantly in the lamellar epithelium, no decrease was found in the interlamellar region of the gill filament. nitrite exposure caused significant reduction on the apical surface area of individual mitochondria-rich cells (p < 0.05 ...201828513781
reduction of the dna damages, hepatoprotective effect and antioxidant potential of the coconut water, ascorbic and caffeic acids in oxidative stress mediated by ethanol.hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. this study aims to identify the main phenol compounds using a new hplc-esi+-ms/ms method, to evaluate some oxidative stress parameters and the hepatoprotective action of green dwarf coconut water, caffeic and ascorbic acids on the liver and serum of rats treated with ethanol. the results showed five polyphenols in the lyophilized coconut water spiked with standa ...201828513780
exploring cryptic diversity and distribution patterns in the mallomonas kalinae/rasilis species complex with a description of a new taxon-mallomonas furtiva sp. nov.a complex of closely related mallomonas taxa belonging to the section papillosae, m. kalinae řezáčová and m. rasilis dürrschmidt, has been studied in detail by molecular and morphometric methods. our investigations uncovered the existence of a new species found in water bodies in vietnam, which we describe here as mallomonas furtiva sp. nov. this taxon is morphologically very similar to m. kalinae, from which it differs by minute, but statistically significant morphological differences on the st ...201828508432
energetic demand and physical conditioning of table tennis players. a study review.table tennis is a racket sport characterised by an intermittent movement profile, including short rallies interspersed with short breaks. in contrast to other racket sports, information is lacking regarding the: (i) physiological responses during table tennis matches and training; and (ii) practical recommendations for enhancing aerobic and anaerobic performance in table tennis by improving cardio-metabolic and neuro-muscular fitness, anthropometry and nutritional strategies. therefore, this rev ...201828582628
morphology and molecular phylogeny of a new hypotrich ciliate, pseudourostyla guizhouensis sp. nov. from southern china, with notes on a chinese population of hemicycliostyla franzi (foissner, 1987) paiva et al., 2012 (ciliophora, hypotricha).the morphology and molecular phylogeny of a soil hypotrich ciliate, pseudourostyla guizhouensis sp. nov., collected from southern china, were investigated. pseudourostyla guizhouensis sp. nov. has an elongate elliptical body measuring 180-310 × 65-85 μm in vivo; invariably two right and three or four left marginal rows; six or seven dorsal kineties; adoral zone consisting of 57-70 membranelles; 12-16 frontal cirri, one buccal cirrus, 13-20 midventral pairs, two frontoterminal cirri, two pretrans ...201828544395
fish parasite dinoflagellates haidadinium ichthyophilum and piscinoodinium share a recent common ancestor.the dinoflagellate haidadinium ichthyophilum buckland-nicks, reimchen and garbary 1997 is an ectoparasite of the spine-deficient, three-spine stickleback gasterosteus aculeatus l. reimchen 1984, a fish endemic to rouge lake, haida gwaii. haidadinium ichthyophilum proved difficult to assign taxonomically because its morphology and complex life cycle exhibited defining characteristics of both autotrophic and heterotrophic dinoflagellates, and was tentatively assigned to the phytodiniales. here, we ...201828544317
the relationship between copper, iron, and selenium levels and alzheimer disease.this study aimed to evaluate the concentrations of copper, iron, and selenium in elderly people with alzheimer disease (ad), comparing the same parameters in a paired group of healthy people, in order to verify if the amount of these metals may influence the cognitive impairment progression. patients' cognitive impairment was evaluated by clinical dementia rating (cdr). the elementary quantification of erythrocytes was performed by inductively coupled plasma mass spectrometry technique. the stat ...201828500578
five-weekly s-1 plus cisplatin therapy combined with trastuzumab therapy in her2-positive gastric cancer: a phase ii trial and biomarker study (wjog7212g).five-weekly s-1 plus cisplatin (sp) therapy is the standard care for advanced gastric or esophagogastric junction cancer (gc/egjc) in east asia. however, its efficacy and safety when combined with trastuzumab therapy for human epidermal growth factor receptor 2 (her2)-positive advanced gc/egjc remains unclear.201828497176
diversity and distribution of epiphytic bromeliads in a brazilian subtropical mangrove.it is not unusual to find epiphytic bromeliads in mangroves, but most studies on mangrove vegetation do not record their presence. this study aimed to evaluate the diversity and distribution of epiphytic bromeliads in a subtropical mangrove. the richness, abundance and life form (atmospheric and tank) of bromeliads were recorded and compared among host tree species and waterline proximity. the effects of diameter and height of host trees on the abundance of bromeliads were also assessed. the man ...201828489202
water temperature, body mass and fasting heat production of pacu (piaractus mesopotamicus).knowledge on fasting heat production (hef) of fish is key to develop bioenergetics models thus improving feeding management of farmed species. the core of knowledge on hef of farmed, neotropical fish is scarce. this study assessed the effect of body mass and water temperature on standard metabolism and fasting heat production of pacu, piaractus mesopotamicus, an omnivore, neotropical fresh water characin important for farming and fisheries industries all through south american continent. an auto ...201828489201
population dynamics of rimapenaeus constrictus (stimpson, 1874) (penaeoidea) on the southeastern brazilian coast: implications for shrimp fishing management from a 5-year study on a bycatch species.this is the first study to evaluate in broad spatiotemporal scales the growth parameters and population structure of rimapenaeus constrictus, a barely damaged species composing the bycatch from shrimp fishing in the western atlantic. the abundance and size-class frequency distribution, growth, longevity and sex ratio were evaluated from monthly samples obtained in the northern littoral of são paulo state from jan/1998 to jun/2003. we measured 5,812 individuals in which the sex ratio was skewed t ...201828489197
parasite infracommunities of leporinus friderici : a comparison of three tributaries of the jurumirim reservoir in southeastern brazil.the degradation and homogenization of natural habitats is considered a major cause of biotic homogenization. many studies have been undertaken on the effects of dams on aquatic wildlife, in particular fish assemblages. but how do dams affect the parasitic fauna of such fish? the aim of the present study was to examine parasitic similarity, comparing the diversity and structure of parasite communities of leporinus friderici (characiformes, anostomidae) in three upstream tributaries under the infl ...201828489196
beef tallow and emulsifier in growing-finishing pig diets.two trials were aimed to evaluate beef tallow in diets with and without emulsifier on performance of pigs at growing-finishing phases. in the first trial, 15 barrows (22.03±0.62 kg) were distributed among three treatments: reference diet; test diet 1 (5% beef tallow) and test diet 2 (10% beef tallow). beef tallow presented average value of 7130.97 kcal me/kg. for the performance trail, 30 barrows (24.85±1.18 kg) were distributed among five treatments: t1 - diet with soybean oil and 3230 kcal me ...201828489195
antiproliferative activity in tumor cell lines, antioxidant capacity and total phenolic, flavonoid and tannin contents of myrciaria floribunda.myrciaria floribunda (h. west ex willd.) o. berg, myrtaceae, is a native plant species of the atlantic rain forest, from north to south of brazil. the lyophilized ethyl acetate extract from the leaves of m. floribunda was investigated for its antiproliferative activity in tumor cell lines, antioxidant capacity and its total phenolic, flavonoid and tannin contents. antiproliferative activity was tested in vitro against seven human cancer cells and against immortalized human skin keratinocytes lin ...201828489194
family physicians report considerable interest in, but limited use of, telehealth services.little is known about the attitudes toward and adoption of telehealth services among family physicians (fps), the largest primary care physician group. we conducted a national survey of fps, randomly sampled from membership organization files, to investigate use of and barriers to using telehealth services.201828484064
funding instability reduces the impact of the federal teaching health center graduate medical education program.the teaching health center graduate medical education (thcgme) program is a decentralized residency training component of the affordable care act, created to combat critical shortages and maldistribution of primary care physicians. the accreditation council of graduate medical education and federal data reveal that the thcgme program accounted for 33% of the net increase in family medicine residency positions between 2011 and 2015. however, amid concerns about the program's stability, the contri ...201828484059
influence of early mineral deposits of silicate- and aluminate-based cements on push-out bond strength to root dentine.to evaluate mineral trioxide aggregate (mta), biodentine and several formulations of calcium aluminate cements (cacb) in terms of their ability to release calcium ions (ca2+ ) and form apatite-like precipitates after short-term immersion in phosphate-buffered saline (pbs) and its influence on the bond strength to the root-end cavity.201828470849
the impact of rapid maxillary expansion on maxillary first molar root morphology of cleft subjects.the aim of this prospective cohort study was to determine the effects of rapid maxillary expansion (rme) on the first molar roots of cleft lip and palate subjects along different root development stages.201828488057
pathophysiology in the comorbidity of bipolar disorder and alzheimer's disease: pharmacological and stem cell approaches.neuropsychiatric disorders involve various pathological mechanisms, resulting in neurodegeneration and brain atrophy. neurodevelopmental processes have shown to be critical for the progression of those disorders, which are based on genetic and epigenetic mechanisms as well as on extrinsic factors. we review here common mechanisms underlying the comorbidity of bipolar disorders and alzheimer's disease, such as aberrant neurogenesis and neurotoxicity, reporting current therapeutic approaches. the ...201828476640
metal versus plastic stents for anastomotic biliary strictures after liver transplantation: a randomized controlled trial.biliary anastomotic stricture occurs in 15% to 20% of patients after deceased orthotopic liver transplantation (olt). it is usually treated endoscopically with multiple plastic stents (mpss), although the use of fully covered self-expandable metal stents (csemss) is emerging. this study aims to compare the efficacy and safety of csemss versus mpss in these patients.201828455159
effect of resistant starch on the intestinal health of old dogs: fermentation products and histological features of the intestinal mucosa.the effects of resistant starch (rs) intake on nutrient digestibility, microbial fermentation products, faecal iga, faecal ph, and histological features of the intestinal mucosa of old dogs were evaluated. the same formulation was extruded in two different conditions: one to obtain elevated starch cooking degree with low rs content (0.21%) and the other lower starch cooking with high rs content (1.46%). eight geriatric beagles (11.5 ± 0.38 years old) were fed each diet for 61 days in a crossover ...201828444804
diagnostic performance of coronary ct angiography, stress dual-energy ct perfusion, and stress perfusion single-photon emission computed tomography for coronary artery disease: comparison with combined invasive coronary angiography and stress perfusion cardiac mri.to investigate the diagnostic performance of coronary computed tomography angiography (ccta), stress dual-energy computed tomography perfusion (de-ctp), stress perfusion single-photon emission computed tomography (spect), and the combinations of ccta with myocardial perfusion imaging (ccta + de-ctp and ccta + spect) for identifying coronary artery stenosis that causes myocardial hypoperfusion. combined invasive coronary angiography (ica) and stress perfusion cardiac magnetic resonance (sp-cmr) i ...201828458600
substance p regulation in epilepsy.epilepsy is a common neurological disease characterized by abnormal temporary discharge of neurons in the central nervous system. in recent years, studies have revealed the localization and changes in the density of neuropeptides, such as substance p (sp) in the pathogenesis of epilepsy. this review is a concise overview of sp and their physiologic and pathologic functions on regulating epilepsy, and the underline mechanisms.201828474564
relapse of congenital thrombotic thrombocytopenic purpura, after spontaneous remission, in a second-trimester primigravida: case report and review of the literature.thrombotic microangiopathy syndrome or thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (ttp-hus) describes distinct diseases sharing common pathological features: microangiopathic hemolytic anemia and thrombocytopenia, without any other apparent cause.201828443948
use of testicular sperm for intracytoplasmic sperm injection in men with high sperm dna fragmentation: a swot analysis.spermatozoa retrieved from the testis of men with high levels of sperm dna fragmentation (sdf) in the neat semen tend to have better dna quality. given the negative impact of sdf on the outcomes of assisted reproductive technology (art), an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection (testi-icsi). in this article, we used a swot (strengths, weaknesses, opportunities, and threats) analysis to summarize the advantages and drawbacks of this ...201828440264
effect of ultrasonic activation on the reduction of bacteria and endotoxins in root canals: a randomized clinical trial.this randomized clinical trial aimed to compare the effectiveness of ultrasonic activation with that of nonactivated irrigation on the removal of bacteria and endotoxin from root canals.201828439928
comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age.the aim of this study was to compare two models of swimming applied to pregnant rats born small for pregnancy age (spa). diabetes was chemically induced in adult female rats to develop an inadequate intrauterine environment, leading to birth of a spa offspring. in adulthood, the female spa rats were mated and submitted to different swimming programs. the exercise program 1 (ex1) consisted of swimming for 15 minutes, followed by 15 minutes of rest and another 15 minutes of swimming, 3 days a week ...201828423082
transmissivity of aquifer by capture zone method: an application in the sete lagoas karst aquifer, mg, brazil.transmissivity is an important hydraulic parameter to determine the amount of water passed horizontally across a given saturated thickness of an aquifer. the techniques to quantify this parameter, such as grain size analyses or pumping tests, can have limitations of time/spatial scale, viability, or economically. one technique that can be used, but little adopted, is the capture zone analysis. in this paper, capture zone analytical equations were used to estimate transmissivity values in order t ...201828423076
on topological groups with an approximate fixed point property.a topological group g has the approximate fixed point (afp) property on a bounded convex subset c of a locally convex space if every continuous affine action of g on c admits a net ( x i ) , x i ∈ c , such that x i - g ⁢ x i ⟶ 0 for all g ∈ g . in this work, we study the relationship between this property and amenability.201828423071
polymorphism in male genitalia of aedes (ochlerotatus) scapularis rondani, 1848.morphology of male genitalia of culicids is generally species-specific and often used as a taxonomic marker. however, some characters of the male genitalia vary intraspecifically and are not taxonomically diagnostic. this might be the case of aedes scapularis, a neotropical culicid with vector competence for arboviruses and filarial worms. males of this species may or not present a retrorse process (rp) in the genitalic claspette filaments, which led authors to suspect that this variance might b ...201828416024
pathophysiological characteristics of preproinsulin-specific cd8+ t cells in subjects with juvenile-onset and adult-onset type 1 diabetes: a 1-year follow-up study.among the beta-cell associated antigens, preproinsulin (ppi) has been shown to play a key role in the pathogenesis of type 1 diabetes (t1d). ppi-specific autoreactive cd8+ t cells emerge early during beta-cell destruction and persist in peripheral circulation during diabetes progression. however, the influence of insulin therapy on phenotype of autoreactive cd8+ t cells in t1d including, juvenile-onset t1d (jot1d), and adult-onset t1d (aot1d) is not yet known.201828488272
[enrichment of the rats diet with docosahexaenoic acid and astaxanthin: physiological and biochemical efficiency].to investigate the effect of enrichment of the rats diet with polyunsaturated fatty acids (pufa) ω-3 (220 mg docosahexaenoic acid per 1 kg of animal body weight per day) and astaxanthin (5 mg/kg body weight) on serum corticosterone concentration, physical fatigue, anxiety of rats after exhausting the load. during 30 days the rats of the test group received the diet in which the usual fat component comprising sunflower oil and lard (1:1) was completely replaced by the mixture of oils (high oleic ...201829363930
memory complaint scale (mcs). proposed tool for active systematic search.subjective memory complaints (smc) are frequent among adults and elderly and are associated with poor quality of life. the etiology and clinical significance of smcs are unclear, but these complaints are associated with objective cognitive decline or with depression, anxiety and psychosocial stressors. biological and physiological brain alterations resembling those in alzheimer's disease have been found in smc. smc can evolve with different outcomes and represent the initial symptom or a risk fa ...201829213800
characterization of novel acidobacteria exopolysaccharides with potential industrial and ecological applications.acidobacteria have been described as one of the most abundant and ubiquitous bacterial phyla in soil. however, factors contributing to this ecological success are not well elucidated mainly due to difficulties in bacterial isolation. acidobacteria may be able to survive for long periods in soil due to protection provided by secreted extracellular polymeric substances that include exopolysaccharides (epss). here we present the first study to characterize epss derived from two strains of acidobact ...201728117455
molecular evidence for the involvement of a polygalacturonase-inhibiting protein, ghpgip1, in enhanced resistance to verticillium and fusarium wilts in cotton.polygalacturonase-inhibiting protein (pgip), belonging to a group of plant defence proteins, specifically inhibits endopolygalacturonases secreted by pathogens. herein, we showed that purified ghpgip1 is a functional inhibitor of verticillium dahliae and fusarium oxysporum f. sp. vasinfectum, the two fungal pathogens causing cotton wilt. transcription of ghpgip1 was increased in cotton upon infection, wounding, and treatment with defence hormone and h2o2. resistance by ghpgip1 was examined by it ...201728079053
screening of alginate lyase-producing bacteria and optimization of media compositions for extracellular alginate lyase production.alginate is a linear polysaccharide consisting of guluronate (polyg) and mannuronate (polym) subunits.201727432784
direct heme uptake by phytoplankton-associated roseobacter bacteria.iron is an essential micronutrient and can limit the growth of both marine phytoplankton and heterotrophic bacterioplankton. in this study, we investigated the molecular basis of heme transport, an organic iron acquisition pathway, in phytoplankton-associated roseobacter bacteria and explored the potential role of bacterial heme uptake in the marine environment. we searched 153 roseobacter genomes and found that nearly half contained putative complete heme transport systems with nearly the same ...201728083564
pantoea alhagi, a novel endophytic bacterium with ability to improve growth and drought tolerance in wheat.a novel strain ltyr-11z(t) that exhibited multiple plant growth promoting (pgp) traits was isolated from the surface-sterilized leaves of alhagi sparsifolia shap. (leguminosae), which reprsents one of the top drought tolerant plants in north-west china. phylogenetic analysis of 16s rrna gene sequences and multilocus sequence analysis based on partial sequences of atpd, gyrb, infb and rpob genes revealed that strain ltyr-11z(t) was a member of the genus pantoea, with pantoea theicola nbrc 110557( ...201728128318
comparison of 16s ribosomal rna gene sequence analysis and conventional culture in the environmental survey of a hospital.nosocomial infection is one of the most common complications within health care facilities. certain studies have reported outbreaks resulting from contaminated hospital environments. although the identification of bacteria in the environment can readily be achieved using culturing methods, these methods detect live bacteria. sequencing of the 16s ribosomal rna (16s rrna) gene is recognized to be effective for bacterial identification. in this study, we surveyed wards where drug-resistant bacteri ...201728116119
antiviral activity of animal venom peptides and related compounds.viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. ...201728074089
first description of leishmania (viannia) infection in evandromyia saulensis, pressatia sp. and trichophoromyia auraensis (psychodidae: phlebotominae) in a transmission area of cutaneous leishmaniasis in acre state, amazon basin, brazil.studies on the sandfly fauna to evaluate natural infection indexes are still limited in the brazilian amazon, a region with an increasing incidence of cutaneous leishmaniasis. here, by using a multiplex polymerase chain reaction directed to leishmania kdna and hybridisation, we were able to identify l. (viannia) subgenus in 12 out of 173 sandflies captured in the municipality of rio branco, acre state, revealing a positivity of 6.94%. by sequencing the leishmania 234 bp-hsp70 amplified products ...201728076470
molecular detection of rickettsia species in ticks collected from the southwestern provinces of the republic of korea.rickettsiae constitute a group of arthropod-borne, gram-negative, obligate intracellular bacteria that are the causative agents of diseases ranging from mild to life threatening that impact on medical and veterinary health worldwide.201728069059
avian malaria on madagascar: bird hosts and putative vector mosquitoes of different plasmodium lineages.avian malaria occurs almost worldwide and is caused by haemosporida parasites (plasmodium, haemoproteus and leucocytozoon). vectors such as mosquitoes, hippoboscid flies or biting midges are required for the transmission of these parasites. there are few studies about avian malaria parasites on madagascar but none about suitable vectors.201728057063
conserved gene expression in sperm reservoirs between birds and mammals in response to mating.spermatozoa are stored in the oviductal functional sperm reservoir in animals with internal fertilization, including zoologically distant classes such as pigs or poultry. they are held fertile in the reservoir for times ranging from a couple of days (in pigs), to several weeks (in chickens), before they are gradually released to fertilize the newly ovulated eggs. it is currently unknown whether females from these species share conserved mechanisms to tolerate such a lengthy presence of immunolog ...201728100167
molecular epidemiology of blastocystis sp. in various animal groups from two french zoos and evaluation of potential zoonotic risk.blastocystis sp. is a common intestinal parasite infecting humans and a wide range of animals worldwide. it exhibits an extensive genetic diversity and 17 subtypes (sts) have thus far been identified in mammalian and avian hosts. since several sts are common to humans and animals, it was proposed that a proportion of human infections may result from zoonotic transmission. however, the contribution of each animal source to human infection remains to be clarified. therefore, the aim of this study ...201728060901
identification and whole genome sequencing of the first case of kosakonia radicincitans causing a human bloodstream infection.the taxonomy of enterobacter species is rapidly changing. herein we report a bloodstream infection isolate originally identified as enterobacter cloacae by vitek2 methodology that we found to be kosakonia radicincitans using genetic means. comparative whole genome sequencing of our isolate and other published kosakonia genomes revealed these organisms lack the ampc β-lactamase present on the chromosome of enterobacter sp. a fimbriae operon primarily found in escherichia coli o157:h7 isolates was ...201728174569
protochlamydia phocaeensis sp. nov., a new chlamydiales species with host dependent replication cycle.chlamydiae are pathogenic and symbiotic bacteria, which form an important part of amoeba-associated microorganisms. in this paper, we report the isolation, developmental cycle and genome analysis of protochlamydia phocaeensis sp. nov., an obligate intracellular parasite with a large host spectrum, able to infect acanthamoeba castellanii, acanthamoeba polyphaga, and vermamoeba vermiformis. the genome size is 3,424,182 bp with a gc content of 42%. this bacterium displayed a particular developmenta ...201728279734
soil bacteria showing a potential of chlorpyrifos degradation and plant growth enhancement.since 1960s, the organophosphate pesticide chlorpyrifos has been widely used for the purpose of pest control. however, given its persistence and toxicity towards life forms, the elimination of chlorpyrifos from contaminated sites has become an urgent issue. for this process bioremediation is the method of choice.201727266625
achromobacter aloeverae sp. nov., isolated from the root of aloe vera (l.) burm.f.two gram-staining-negative, strictly aerobic, rod-shaped bacteria, designated strains ava-1t and ava-2, were isolated from the root of aloe vera (l.) brum.f. derived from chachoengsao province, thailand. the strains contained cytochrome oxidase and catalase activities. they grew in 4 % (w/v) nacl, at a ph range of 6.0-9.0 (optimally at ph 7) and at 20-42 °c (optimally at 30-37 °c). the major isoprenoid quinone was ubiquinone with eight isoprene units (q-8). the major fatty acids were c16 : 0 and ...201727902206
isolation of bacterial strains able to degrade biphenyl, diphenyl ether and the heat transfer fluid used in thermo-solar plants.thermo-solar plants use eutectic mixtures of diphenyl ether (de) and biphenyl (bp) as heat transfer fluid (htf). potential losses of htf may contaminate soils and bioremediation is an attractive tool for its treatment. de- or bp-degrading bacteria are known, but up to now bacteria able to degrade htf mixture have not been described. here, five bacterial strains which are able to grow with htf or its separate components de and bp as sole carbon sources have been isolated, either from soils expose ...201727884748
nosocomial infections with imp-19-producing pseudomonas aeruginosa linked to contaminated sinks, france.we isolated imp-19-producing pseudomonas aeruginosa from 7 patients with nosocomial infections linked to contaminated sinks in france. we showed that blaimp-19 was located on various class 1 integrons among 8 species of gram-negative bacilli detected in sinks: p. aeruginosa, achromobacter xylosoxidans, a. aegrifaciens, p. putida, stenotrophomonas maltophilia, p. mendocina, comamonas testosteroni, and sphingomonas sp.201728098548
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