Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| 3-monoiodothyronamine: the rationale for its action as an endogenous adrenergic-blocking neuromodulator. | the investigations reported here were designed to gain insights into the role of 3-monoiodothyronamine (t1am) in the brain, where the amine was originally identified and characterized. extensive deiodinase studies indicated that t1am was derived from the t4 metabolite, reverse triiodothyronine (revt3), while functional studies provided well-confirmed evidence that t1am has strong adrenergic-blocking effects. because a state of adrenergic overactivity prevails when triiodothyronine (t3) concentra ... | 2010 | 20615397 |
| development of morulae from the oocytes of cultured sheep preantral follicles. | sheep preantral follicles (pfs) measuring 250-400 microm in diameter were cultured for six days in serum-free media supplemented differently with growth factors and hormones. subsequently, oocytes from the cultured follicles were subjected to an additional 24 h of in vitro maturation (ivm) followed by in vitro fertilization (ivf) and embryo culture for 6 days. five different experiments were conducted. in the first experiment individual concentrations of insulin-transferrin-selenite (its), insul ... | 2010 | 20615540 |
| systematic review: should routine resection of the extra-hepatic bile duct be performed in gallbladder cancer? | complete surgical resection is associated with improved outcomes in gallbladder cancer. whether the extra-hepatic bile duct (ehbd) should be routinely excised for gallbladder cancer is unclear. | 2010 | 20616410 |
| molecular regulation of thyroid gland function. | for de-novo thyroid hormone synthesis ex vivo, thyroid follicular cells require a serum-free medium supplying nutrients, iodide, thyroid-stimulating hormone and insulin-like growth factor i (igf-i) (or insulin). under these conditions, t3 and t4 are secreted but so are other factors such as growth factors, plasminogen activators, their inhibitors known as serpins, and so on. what is the function of these factors? do thyroid cells respond to them or are these paracrine/endocrine factors? the purp ... | 2010 | 20616713 |
| usefulness of endoscopic ultrasonography in preoperative gastric cancer staging: diagnostic yield and therapeutic impact. | to evaluate the diagnostic yield of endoscopic ultrasonography in loco-regional staging of gastric cancer in our medium and to determine the impact of this technique on later therapeutic management. | 2010 | 20617861 |
| can increasing the dose of radiation by hdr brachytherapy boost following pre operative chemoradiotherapy for advanced rectal cancer improve surgical outcomes? | preoperative radiotherapy has been shown to improve local control in advanced rectal carcinoma compared with surgery alone. several large randomized trials have confirmed that chemoradiotherapy (crt) is better than radiotherapy alone. this pilot study was designed to increase the radiation dose using high-dose rate (hdr) brachytherapy boost following preoperative crt to evaluate whether this strategy improves the outcome of surgery without increase in toxicity. | 2010 | 20618365 |
| neurochemical measures co-vary with personality traits: forensic psychiatric findings replicated in a general population sample. | neurobiological markers in cerebrospinal fluid (csf) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. results on the karolinska scales of personality (ksp) and the temperament and character inventory (tci) were compared with csf/serum albumin ratios and serum concentrations of beta-trace protein (betatp) (as markers for blood-brain barrier (bbb) permeability), t ... | 2010 | 20619466 |
| high-dose split-course radiation therapy for anal cancer: outcome analysis regarding the boost strategy (cors-03 study). | to retrospectively assess the clinical outcome in anal cancer patients treated with split-course radiation therapy and boosted through external-beam radiation therapy (ebrt) or brachytherapy (bct). | 2010 | 20619552 |
| stage iv prostate cancer: survival differences in clinical t4, nodal and metastatic disease. | in the prostate specific antigen era most prostate cancer presents at an early stage. however, a significant number of patients have advanced disease, including those with stage iv disease. assignment to stage iv prostate cancer may occur by different modes, namely as t4n0m0 vs n1 vs m1 disease. we hypothesize that patients with clinical t4 disease have better outcomes than those with n1 or m1 disease. | 2010 | 20620410 |
| survival in oral cavity minor salivary gland carcinoma. | to describe the epidemiology and comparative survival for minor salivary gland cancer of the oral cavity. | 2010 | 20620630 |
| does surgery have a role in t4n0 and t4n1 lung cancer? | a best evidence topic in thoracic surgery was written according to a structured protocol. the question addressed whether [surgery] has a role in [treatment of t4n0 and t4n1 lung cancer]. altogether more than 151 papers were found using the reported search, of which 15 represented the best evidence to answer the clinical question. the authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. we conclude that ... | 2010 | 20621998 |
| hypothyroid phenotype of the tpst2 mutant mouse is dependent upon genetic background. | dw/j-grt is a congenital hypothyroid mouse model that is characterized by growth retardation, significantly lowered t3 and t4 levels, and severe thyroid hypoplasia related to tsh hyporesponsiveness. previously, we identified the point mutation of the tpst2 gene in dw/j-grt mice that causes a decrease in the enzymatic activity, and demonstrated that the tpst2 transgene rescues the mutant phenotypes both in vitro and in vivo. the severity of hypothyroidism is highly variable indicating the influen ... | 2010 | 20622471 |
| thyroid hormones, mitochondrial bioenergetics and lipid handling. | the article is principally intended to describe the recent evolutions in the field of research concerned with the metabolic actions of thyroid hormones and those of some of their metabolites or derivatives. mitochondria, as a result of their functions, represent the principal objective of scientists investigating the mechanisms underlying the effects of thyroid hormones or their metabolites/derivatives. | 2010 | 20625286 |
| [comparing extended vertical partial laryngectomy and cricohyoidoepiglottopexy in the treatment of laryngeal carcinoma]. | to compare the results of extended vertical partial laryngectomy (similar to modified supracricoid partial laryngectomy with cricohyoidoepiglottopexy) and cricohyoidoepiglottopexy in the treatment of laryngeal carcinoma. | 2010 | 20627050 |
| hydrolytic cleavage of double-strand dna by the water-soluble dicobalt(iii) complexes of 1,4,7-triazacyclononane-n-acetate. | three water-soluble dicobalt(iii) complexes, [co(2)l(2)(micro-oh)(2)](clo(4))(2).5h(2)o (1), [co(2)l(2)(micro-oh)(2)](clo(4))(2).ch(3)oh.h(2)o(2); [co(2)l(2)(micro-oh)(2)](clo(4))(2).4h(2)o(3) (l=1,4,7-triazacyclononane-n-acetate monoanion), were prepared to serve as nuclease mimics. the complexes were characterized by x-ray, ir and uv-vis spectroscopy as well as esi-ms. three complexes exhibit similar structures, just with different solvent molecules. the electrospray mass spectrum of 1 in solu ... | 2010 | 20627402 |
| epirubicin and docetaxel as neoadjuvant treatment of locally advanced breast cancer: a phase ii study. | neoadjuvant chemotherapy is the standard treatment for locally advanced breast cancer. the combination of anthracyclines and taxanes is considered the first choice chemotherapy in advanced breast cancer. we report here the overall results of a phase ii study of epirubicin and docetaxel as neoadjuvant chemotherapy in advanced breast cancer. | 2010 | 20572578 |
| clinical features of primary hyperthyroidism caused by graves' disease admixed with resistance to thyroid hormone (p453t). | a 34-year-old japanese woman was referred to the hospital because of general fatigue and palpitations. she was diagnosed as having resistance to thyroid hormone (rth) and hashimoto's thyroiditis at the age of 28. she felt general fatigue, palpitations, heat intolerance, and sweating for 6 months. thyroid function tests demonstrated elevated levels of free triidothyronine (t3) and free thyroxine (t4) that were above detectable ranges and a completely suppressed level of tsh that was below the det ... | 2010 | 20574139 |
| the sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid photosensitizes the formation of oxidized guanines in cellulo after uv-a or uv-b exposure. | the sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid (pbsa) is water soluble and is widely used in the cosmetic industry because it absorbs strongly at uv-b wavelengths. previous studies have shown that pbsa, photoexcited by uv-b, oxidizes guanine bases in vitro. because of its potential phototoxic effect, it is important to determine whether pbsa photosensitizes in cellulo the formation of oxidatively generated dna damage on uv exposure. for this purpose, we investigated, in vitro and in c ... | 2010 | 20574440 |
| incremental effects of facemask therapy associated with intermaxillary mechanics. | to determine the dentofacial changes in children with skeletal class iii malocclusions treated with maxillary expansion, external maxillary protraction and intermaxillary traction. | 2010 | 20575205 |
| nasopharyngeal carcinoma: differences in presentation between different ethnicities in the new zealand setting. | there is an elevated incidence of nasopharyngeal carcinoma (npc) in the maori and pacific island (mpi) population as well as the asian population in new zealand; however, no studies have been conducted to evaluate how the two populations differ in their clinical presentation according to the tnm stage. | 2010 | 20575952 |
| postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge. | postoperative residual curarization (porc) [train-of-four ratio (t4/t1) <0.9] is associated with increased morbidity and may delay postoperative recovery room (pacu) discharge. we tested the hypothesis that postoperative t4/t1 <0.9 increases pacu length of stay. | 2010 | 20576632 |
| changes in temporomandibular joint disc position and form following herbst and fixed orthodontic treatment. | to determine the changes in the position and form of the temporomandibular joint articular disc in adolescents with class ii division 1 malocclusion and mandibular retrognathism treated with the herbst appliance (phase i) and fixed orthodontic appliance (phase ii). | 2010 | 20578854 |
| phylogenetic diversity of t4-like bacteriophages in lake baikal, east siberia. | among the tailed phages, the myoviruses, those with contractile tails, are widespread and diverse. an important component of the myoviridae family is the genus 't4-like viruses'. the present study was aimed at elucidating the molecular diversity of t4-type bacteriophages in lake baikal by partial sequencing of g23 genes of t4-type bacteriophages. our study revealed that the g23 gene sequences investigated were highly diverse and different from those of t4-like bacteriophages and from g23 clones ... | 2010 | 20579103 |
| is breast conservation therapy a viable option for patients with triple-receptor negative breast cancer? | triple-receptor negative breast cancers (tnbc) are aggressive neoplasms that lack estrogen-receptor, progesterone-receptor, and her-2 expressions. comparative analysis of breast conservation therapy (bct) versus mastectomy for tnbc is reported sparsely. we hypothesized that, despite its aggressive behavior, tnbc can be managed with bct. | 2010 | 20580045 |
| intestinal permeability enhancement of levothyroxine sodium by straight chain fatty acids studied in mdck epithelial cell line. | levothyroxine sodium (t4), administered orally, is used for the treatment of hypothyroidism. t4 is a narrow therapeutic index drug with highly variable bioavailability (40-80%). the purpose of the present study was to increase the transepithelial transport of t4 using straight chain fatty acids across madin-darby canine kidney (mdck) cell line. capric acid (c10), lauric acid (c12) and oleic acid (c18) were studied in molar ratios of 1:0.5, 1:1, 1:2 and 1:3 (t4:fatty acid). transport of the hydro ... | 2010 | 20580671 |
| effect of celecoxib combined with thoracic epidural analgesia on pain after thoracotomy. | thoracotomy results in severe postoperative pain potentially leading to chronic pain. we investigated the potential benefits of oral celecoxib on postoperative analgesia combined with thoracic epidural analgesia (tea). | 2010 | 20581214 |
| floating tablet of trimetazidine dihydrochloride: an approach for extended release with zero-order kinetics. | trimetazidine dihydrochloride is an effective anti-anginal agent; however, it is freely soluble in water and suffers from a relatively short half-life. to solve this encumbrance, it is a prospective candidate for fabricating trimetazidine extended-release formulations. trimetazidine extended-release floating tablets were prepared using different hydrophilic matrix forming polymers including hpmc 4000 cps, carbopol 971p, polycarbophil, and guar gum. the tablets were fabricated by dry coating tech ... | 2010 | 20582493 |
| prospective study of sexual dysfunction in men with rectal cancer: feasibility and results of nerve sparing surgery. | rectal cancer surgery is impaired by a high rate of postoperative sexual dysfunction cause of frequent nerve injuries. the aim of this study was to prospectively evaluate sexual function in a group of male patients after total mesorectal excision (tme) for rectal cancer, using an autonomic nerve sparing technique. | 2010 | 20582547 |
| does thyroid gland examination by palpation alter serum hormone levels? | the goal of this study was to investigate the effects of routine thyroid gland palpation on serum thyroid hormone levels. | 2010 | 20583234 |
| autoimmune thyroiditis and diabetes mellitus type 1 after long-term gonadotropin-releasing hormone agonist treatment for central precocious puberty: evolution or coincidence? | very few abnormalities in endocrine function have been reported during long term gonadotropin-releasing hormone agonist (gnrha) treatment in girls. most authors agree that this therapy is safe and effective. we present an unusual outcome of long term gnrha therapy in two girls with central precocious puberty(cpp) of idiopathic or organic origin. they have received monthly depot injections of triptorelin acetate for a time period of 8 years. thyroid function was examined by measuring serum levels ... | 2010 | 20583547 |
| cross-language perception of non-native tonal contrasts: effects of native phonological and phonetic influences. | this study examined the perception of the four mandarin lexical tones by mandarin-naïve hong kong cantonese, japanese, and canadian english listener groups. their performance on an identification task, following a brief familiarization task, was analyzed in terms of tonal sensitivities (a-prime scores on correct identifications) and tonal errors (confusions). the a-prime results revealed that the english listeners' sensitivity to tone 4 identifications specifically was significantly lower than t ... | 2010 | 20583732 |
| prevalence and pattern of nodal metastasis in pt4 gingivobuccal cancers and its implications for treatment. | the pattern of nodal spread in oral cancers is largely predictable and treatment of neck can be tailored with this knowledge. most studies available on the pattern are from the western world and for early cancers of the tongue and floor of the mouth. | 2010 | 20587912 |
| thoracic vertebral cavernous hemangioma in a schizophrenic patient--case report. | a 55-year-old man presented with gait disturbance, incontinence, and back pain. he had a medical history of schizophrenia for the past 35 years. computed tomography (ct) and magnetic resonance imaging suggested thoracic vertebral hemangioma. dynamic ct incidentally detected a hepatic hemangioma. laminectomy of t3 and t4, resection of the epidural hemangioma, and rigid instrumentation between t1 and t6 using rod and hook systems were performed. postoperatively, his symptoms completely disappeared ... | 2010 | 20587975 |
| molecular characterization and gene expression of thyrotropin-releasing hormone in senegalese sole (solea senegalensis). | we describe the cloning of a cdna encoding trh in solea senegalensis. phylogenetic analysis clustered it with other fish counterparts. eight conserved trh progenitors and highly divergent spacers were identified. expression profiles of trh were analyzed in juvenile tissues, during larval development, and in post-larvae grew under four photoperiods (12l:12d, 12d:12l, 24l:0d and 24d:0l) during four weeks using a real-time pcr approach. in juvenile fish, trh mrna was expressed ubiquitously although ... | 2010 | 20570750 |
| early-stage invasive breast cancers: potential role of optical tomography with us localization in assisting diagnosis. | to investigate the potential role of optical tomography in the near-infrared (nir) spectrum with ultrasonographic (us) localization as a means of differentiating early-stage cancers from benign lesions of the breast. | 2010 | 20571122 |
| effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer: a single-center experience in 263 patients. | to determine the frequency of local recurrence (lr) and distant recurrence (dr) with 5-year survival analysis. | 2010 | 20571269 |
| thyroid hormone receptor alpha1 downregulation in postischemic heart failure progression: the potential role of tissue hypothyroidism. | thyroid hormone (th) signaling is altered in response to various stresses including myocardial ischemia. the present study investigated potential implication of th signaling in the pathophysiology of postischemic remodeling. acute myocardial infarction was induced in rats by coronary artery ligation (ami). after 34 weeks, 6 animals were on congestive heart failure (chf) as indicated by measurements in lung and right ventricular weight. 7 animals were in compensated state (non-chf) and 8 sham-ope ... | 2010 | 20560106 |
| [the role of the "heil- und pflegeanstalt" (state hospital) günzburg in the context of the "aktion-t4"]. | in the context of the national socialist "aktion-t4" approximately 70,000 people with mental illness and mental handicap in germany were killed. the "heil- und pflegeanstalt" (mental hospital) günzburg was a so-called bavarian "sammelanstalt" during this period. | 2010 | 20560117 |
| [spontaneous spinal subdural and epidural haematoma in a pregnant patient]. | we report a pregnant woman who developed non-traumatic spinal subdural and epidural hematoma. a 31-year-old woman at 28 weeks of gestation developed progressive ascending paralysis. mri suggested the presence of spinal subdural hematoma at t4-6 and spinal epidural hematoma at t4-9. an emergency cesarean section followed by spinal decompression was performed 60 hours after the onset. the patient's neulogical function recovered completely after the surgey. | 2010 | 20560387 |
| [adult male with tubulointerstitial nephritis and uveitis syndrome complicated with thyroiditis]. | renal dysfunction was detected by routine medical examination in a 46-year-old man (blood urea nitrogen : 26 mg/dl, creatinine : 2.4 mg/dl and moderate proteinuria). a few weeks later, he visited a local ophthalmologist complaining of left eye pain and red eye. he was diagnosed as left uveitis, prescribed eye-drops and referred to our hospital for further examination. at the first visit, test results pointed to renal dysfunction and a high level of thyroid hormones (creatinine : 1.8 mg/dl, free ... | 2010 | 20560474 |
| inhibitory effects of diacylglyceride phospholipids on dna polymerase and topoisomerase activities, and human cancer cell growth. | this paper describes the inhibitory activities of diacylglyceride phospholipids, such as phosphatidylcholine (lecithin), phosphatidylethanolamine (cephalin), phosphatidylserine, phosphatidylglycerol, bisphosphatidylglycerol (cardiolipin), phosphatidylinositol, and phosphatidic acid (phosphatidate) (compounds 1 - 7, respectively) against dna polymerase (pol), dna topoisomerase (topo), and human cancer cell growth. among the compounds tested, compounds 3 - 7 were revealed to be potent inhibitors o ... | 2010 | 20507270 |
| non-invasive measurement of thyroid hormone in feces of a diverse array of avian and mammalian species. | we developed and validated a non-invasive thyroid hormone measure in feces of a diverse array of birds and mammals. an i(131) radiolabel ingestion study in domestic dogs coupled with high pressure liquid chromatography (hplc) analysis, showed that peak excretion in feces occurred at 24-48h post-ingestion, with i(131)-labelled thyroid hormone metabolites excreted primarily as triiodothyronine (t3) and relatively little thyroxine (t4), at all excretion times examined. the immunoreactive t3 profile ... | 2010 | 20412809 |
| comparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats. | thyroid hormones (ths) play a crucial role in the development and physiological functioning of different body organs especially the brain. therefore, the objective of this study was to show the histopathological effects of the different thyroid states on some brain regions (cerebrum and cerebellum) and the skeletal features of their newborns during the postnatal development from the 1st to 3rd week. the female white albino rats were allocated into 3 groups as follows: the experimental hypothyroi ... | 2010 | 20412848 |
| morphometric analysis of the thoracic pedicle: an anatomico-radiological study. | knowledge of the morphometric anatomy of the pedicles in thoracic spine is essential for the surgeon attempting thoracic pedicle screw placement. | 2010 | 20508345 |
| predictive value of 18f-fluorodeoxyglucose uptake by positron emission tomography for non-small cell lung cancer patients treated with radical radiotherapy. | the purpose of this study is to assess predictive value of the positron emission tomography (pet) with 18f-fluoro-deoxyglucose (fdg) for recurrence and survival after radiotherapy (rt) for non-small cell lung cancer (nsclc). one hundred forty-nine patients underwent pretreatment pet (n = 67) or pet/computed tomography (ct) (n = 82) and definitive rt for nsclc. we evaluated the relationship between the maximum-pixel standardized uptake value (suv(max)) and clinical tumor features. univariate cox ... | 2010 | 20508373 |
| genotypic characterization of acanthamoeba spp. causing ocular infections in swedish patients: identification of the t15 genotype in a case of protracted keratitis. | the genus acanthamoeba represents free-living amoebae typically widespread in soil and water. it consists of more than 20 known species representing 15 genotypes of different pathogenicity and virulence. the aim of the study was the genotypic characterization of acanthamoeba spp. isolated from human keratitis cases in sweden. thirteen amoeba isolates obtained from contact lens users with suspected acanthamoeba keratitis (ak) were subjected to polymerase chain reaction amplification and subsequen ... | 2010 | 20524785 |
| surgery for malignant pleural mesothelioma. | the role of surgery for malignant pleural mesothelioma encompasses the need for rapid diagnosis, preoperative staging and surgical resection, and also the need for a greater biological understanding of this rare and aggressive malignancy. in the multimodality treatment paradigm, the goal of surgery is to provide a macroscopic complete resection (i.e., complete removal of all grossly visible tumor). two operations have evolved: extrapleural pneumonectomy and pleurectomy/decortication. the former ... | 2010 | 20524919 |
| [sentinel lymph node biopsy in patients with melanoma]. | the incidence of melanoma is currently increasing worldwide. one of the factors influencing disease prognosis is the presence of regional lymph node metastases. sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease. the aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease pro ... | 2010 | 20525486 |
| thyroid axis dysfunction in patients with prader-willi syndrome during the first 2 years of life. | prader-willi syndrome (pws) is a genetic disorder caused by the loss of expression of paternally transcribed genes in a highly imprinted region of chromosome 15q11-13. the clinical phenotype has been well characterized, mostly related to hypothalamic dysfunction. even though central hypothyroidism has been documented in 20-30% of patients with pws, thyroid function during the first 2 years of life has not been clearly defined. | 2010 | 20560980 |
| sacral neuromodulation in children with urinary and fecal incontinence: a multicenter, open label, randomized, crossover study. | the clinical benefit of sacral neuromodulation is unclear due to the paucity of randomized trial data. the purpose of this study was to evaluate sacral neuromodulation for management of urinary and fecal incontinence in a pediatric population. | 2010 | 20561645 |
| goitrogenic/antithyroidal potential of green tea extract in relation to catechin in rats. | catechins are flavonoids found in abundance in green tea, have elicited high interest due to their beneficial effects on health. though flavonoids have been reported to have an antithyroid effect and also to be goitrogenic there have been no reports about the effect of green tea on rat thyroid. the present study was designed to examine whether high doses of green tea has any harmful effect on thyroid physiology. for this purpose green tea extract was administered orally to male albino rats for 3 ... | 2010 | 20561943 |
| bacteriophage-based biosorbents coupled with bioluminescent atp assay for rapid concentration and detection of escherichia coli. | wild type t4 bacteriophage and recombinant t4 bacteriophages displaying biotin binding peptide (bccp) and cellulose binding module (cbm) on their heads were immobilized on nano-aluminum fiber-based filter (disruptor), streptavidin magnetic beads and microcrystalline cellulose, respectively. infectivity of the immobilized phages was investigated by monitoring the phage-mediated growth inhibition of bioluminescent e. coli b and cell lysis using bioluminescent atp assay. the results showed that pha ... | 2010 | 20561957 |
| polybrominated diphenyl ether (pbde) flame retardants and thyroid hormone during pregnancy. | human exposure to polybrominated diphenyl ether (pbde) flame retardants has increased exponentially over the last three decades. animal and human studies suggest that pbdes may disrupt thyroid function. although thyroid hormone (th) of maternal origin plays an essential role in normal fetal brain development, there is a paucity of human data regarding associations between exposure to pbdes and maternal th levels during pregnancy. | 2010 | 20562054 |
| laparoscopic colorectal surgery produces better outcomes for high risk cancer patients compared to open surgery. | the excellent outcomes reported for laparoscopic colorectal surgery in selected patients could also be potentially advantageous for high risk patients. this prospective study was designed to examine the feasibility and safety of laparoscopic resection in high risk patients with colorectal cancer. | 2010 | 20562603 |
| the bispectral electroencephalogram during modified electroconvulsive therapy under propofol anesthesia: relation with seizure duration and awakening. | implication statement:: use of the bispectral electroencephalogram during modified electroconvulsive therapy (mect) under propofol anesthesia was found to be an accurate predictor of seizure duration and awakening. this may have potential clinical implications on therapeutic success and elimination of the undesirable effects associated with this treatment modality. | 2010 | 20562643 |
| sewage bacteriophage inactivation by cationic porphyrins: influence of light parameters. | photodynamic therapy has been used to inactivate microorganisms through the use of targeted photosensitizers. although the photoinactivation of microorganisms has already been studied under different conditions, a systematic evaluation of irradiation characteristics is still limited. the goal of this study was to test how the light dose, fluence rate and irradiation source affect the viral photoinactivation of a t4-like sewage bacteriophage. the experiments were carried out using white par light ... | 2010 | 20563346 |
| identification of qtl associated with resistance to bacterial spot race t4 in tomato. | bacterial spot of tomato (solanum lycopersicum l.), caused by several xanthomonas sp., is a serious but difficult disease to control by chemical means. development of resistance has been hindered by emergence of races virulent to tomato, by the quantitative inheritance of resistance, and by a low correlation between seedling assays and resistance in the field. resistance to multiple races, including race t4, has been described in the s. lycopersicum var. cerasiformae accession pi 114490. we used ... | 2010 | 20563547 |
| molecular cloning and regulation of mrna expression of the thyrotropin β and glycoprotein hormone α subunits in red drum, sciaenops ocellatus. | full-length cdnas for thyrotropin β (tshβ) and glycoprotein hormone α (gsuα) subunits were cloned and sequenced from the red drum (sciaenops ocellatus). the cdnas for tshβ (877 bp) and gsuα (661 bp) yielded predicted coding regions of 126 and 94 amino acid proteins, respectively. both sequences contain all invariant cysteine and putative glycosylated asparagines characteristic of each as deduced by comparison with other gsuα and tshβ sequences from representative vertebrate species. multiple pro ... | 2010 | 20563882 |
| multifactorial, site-specific recurrence model after radical cystectomy for urothelial carcinoma. | a scoring algorithm of site-specific disease recurrence after cystectomy for urothelial carcinoma was designed. | 2010 | 20564121 |
| 2,3,7,8,12,13-hexaaryltruxenes: an ortho-substituted multiarm design and microwave-accelerated synthesis toward starburst macromolecular materials with well-defined pi delocalization. | we present herein a novel design and the efficient synthesis towards a "homogeneous" starburst fluorene system based on the novel 2,3,7,8,12,13-hexaaryltruxene scaffold. controlled microwave heating provides a facile and powerful approach for each step in the synthesis of these bulky materials with large steric hindrance, suggesting an avenue to access structurally well-defined complex organic semiconductors (oscs) rapidly and conveniently with high yield and purity. the resulting materials exhi ... | 2010 | 20564289 |
| accuracy of multidetector computed tomography in identifying poor prognostic factors in colonic cancer. | recent neoadjuvant strategies for high-risk colonic tumours have renewed interest in accurate preoperative staging. the aim of this study was to validate prospectively the accuracy of multidetector computed tomography (mdct) in stratifying patients into good and poor prognostic groups in a multicentre setting. | 2010 | 20564305 |
| factors associated with nonparticipation in one-year quality-of-life assessment in patients with head and neck squamous cell carcinoma. | to identify factors associated with nonparticipation in long-term quality-of-life (qol) analysis in head and neck squamous cell cancer (hnscc) patients. | 2010 | 20564472 |
| sequential chemoradiotherapy in advanced laryngeal cancer: an institutional experience. | the objective of this study was to determine the efficacy of sequential chemoradiation for larynx preservation. | 2010 | 20565422 |
| genetically engineered virulent phage banks in the detection and control of emergent pathogenic bacteria. | natural outbreaks of multidrug-resistant microorganisms can cause widespread devastation, and several can be used or engineered as agents of bioterrorism. from a biosecurity standpoint, the capacity to detect and then efficiently control, within hours, the spread and the potential pathological effects of an emergent outbreak, for which there may be no effective antibiotics or vaccines, become key challenges that must be met. we turned to phage engineering as a potentially highly flexible and eff ... | 2010 | 20569057 |
| overlap extension pcr cloning: a simple and reliable way to create recombinant plasmids. | here we describe a straightforward, efficient, and reliable way to clone an insert of choice into a plasmid of choice without restriction endonucleases or t4 dna ligase. chimeric primers containing plasmid sequence at the 5' ends and insert sequence at the 3' ends were used to pcr-amplify insertion sequences of various sizes, namely the genes for gfp (gfp), beta-d-glucuronidase (gusa), and beta-galactosidase (lacz), as well as the entire luxabcde operon. these inserts were employed as mega-prime ... | 2010 | 20569222 |
| a comparison of the effect on qt interval between thiamylal and propofol during anaesthetic induction*. | summary: the aim of this study was to determine the effect of thiamylal and propofol on heart rate-corrected qt (qtc) interval during anaesthetic induction. we studied 50 patients undergoing lumbar spine surgery. patients were administered 3 microgxkg(-1) fentanyl and were randomly allocated to receive 5 mgxkg(-1) thiamylal or 1.5 mgxkg(-1) propofol as an induction agent. tracheal intubation was performed after vecuronium administration. heart rate, mean arterial pressure, bispectral index score ... | 2010 | 20528837 |
| effect of thyroid statuses on sodium/iodide symporter (nis) gene expression in the extrathyroidal tissues in mice. | abstract: | 2010 | 20529371 |
| the effects of stimulating lower leg muscles on the mechanical work and metabolic response in functional electrically stimulated pedaling. | functional electrical stimulation (fes) pedaling with the muscles of the upper leg has been shown to provide benefit to spinal cord injured (sci) individuals. fes pedaling with electrical stimulation timing patterns that minimize the stress-time integral of activated muscles has been shown to increase the work individuals can perform during the exercise compared to existing fes stimulation timing patterns. activation of the lower leg muscles could further enhance the benefit of fes pedaling by i ... | 2010 | 20529755 |
| inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate. | thyroid gland explant cultures from prometamorphic xenopus laevis tadpoles were evaluated for their utility in assessing chemicals for thyroid hormone (th) synthesis disruption. the response of cultured thyroid glands to bovine thyroid stimulating hormone (btsh) and the th synthesis inhibitors methimazole, 6-propylthiouracil, and perchlorate was determined. thyroid glands continuously exposed for 12 days to graded concentrations of btsh released thyroxine (t4) in a dose-dependent manner. over ti ... | 2010 | 20530234 |
| [the beta-helical domain of bacteriophage t4 controls the folding of the fragment of long tail fibers in a chimeric protein]. | the key stage of the infection of the escherichia coli cell with bacteriophage t4, the binding to the surface of the host cell, is determined by the specificity of the long tail fiber proteins of the phage, in particular, gp37. the assembly and oligomerization of this protein under natural conditions requires the participation of at least two additional protein factors, gp57a and gp38, which strongly hinders the production of the recombinant form of gp37. to overcome this problem, a modern prote ... | 2010 | 20531477 |
| abcb1/mdr1 gene polymorphisms as a prognostic factor in colorectal cancer. | to analyse the single-nucleotide polymorphisms (snps): abcb1(1236c>t), abcb1(2677g>t/a), abcb1(3435c>t) and haplotypes in the abcb1/mdr1 gene, which could contribute to genetic risk of colorectal cancer (crc). disease association between the abcb1/mdr1 genotype, allele, haplotype frequencies and histological features, such as tnm classification, localization of primary carcinoma, grade of malignancy, histological type of tumour, lymphoid infiltration and vessel invasion were estimated. in this s ... | 2010 | 20533057 |
| chronic kidney disease-epidemiology formula and model for end-stage liver disease score in the assessment of renal function in candidates for liver transplantation. | assessment of renal function in patients with end-stage liver disease (esld) awaiting liver transplantation (olt) is critical. various conditions may cause renal damage in esld. renal and liver functions are intertwined due to splanchnic hemodynamic relationships; renal failure rarely occurs in patients without advanced decompensated cirrhosis. the recent literature suggests that evaluation of renal function should include an assessment of liver function. the aim of this study was to evaluate di ... | 2010 | 20534268 |
| investigations of thyroid hormones and antibodies in obesity: leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants. | obesity can alter the thyroid hormone status as a result of a dysregulated endocrine loop between the hypothalamo-pituitary unit and adipose tissue. the adipocytokine leptin has been shown to promote autoimmunity; hence, we aimed to clarify whether leptin excess of obesity could increase the susceptibility to develop autoimmune thyroid disease (aitd). | 2010 | 20534769 |
| [protective effect of breviscapine on cardiac function in children after cardiopulmonary bypass undergoing open heart surgery]. | to assess the condition of myocardial injury after cardiopulmonary bypass (cpb) and the effects of breviscapine (bvc) on cardiac function in children undergoing open heart surgery. | 2010 | 20535923 |
| [significance of ipsilateral adrenalectomy in surgery for renal cell carcinoma]. | the aim of this study is to analyze the incidence of involvement of ipsilateral adrenal gland from renal cell carcinoma and assess the actual significance of ipsilateral adrenalectomy at nephrectomy. | 2010 | 20535986 |
| congenital hypothyroidism. | congenital hypothyroidism (ch) occurs in approximately 1:2,000 to 1:4,000 newborns. the clinical manifestations are often subtle or not present at birth. this likely is due to trans-placental passage of some maternal thyroid hormone, while many infants have some thyroid production of their own. common symptoms include decreased activity and increased sleep, feeding difficulty, constipation, and prolonged jaundice. on examination, common signs include myxedematous facies, large fontanels, macrogl ... | 2010 | 20537182 |
| eosinophilic vasculitis of the spinal cord associated with churg-strauss syndrome. | eosinophilic vasculitis has been described as part of churg-strauss syndrome (css), but it also affects the central nervous system in <10% of cases. however, spinal cord involvement in css has not been reported. we report a patient with myelopathic symptoms, with a two-year history of asthma. laboratory tests revealed leukocytosis, with 31.7% eosinophils. a chest computed tomographic scan and radiography showed patchy bilateral areas of consolidation, predominantly involving the peripheral regio ... | 2010 | 20538303 |
| medium-term results of neoadjuvant systemic chemotherapy using irinotecan, 5-fluorouracil, and leucovorin in patients with locally advanced rectal cancer. | the aim of this study was to evaluate the usefulness of neoadjuvant systemic chemotherapy using irinotecan, 5-fu, and leucovorin (lv) for the treatment of locally advanced rectal cancer, which was a powerful ploychemotherapy in those days in japan. | 2010 | 20538422 |
| novel recombinant engineered gp41 n-terminal heptad repeat trimers and their potential as anti-hiv-1 therapeutics or microbicides. | peptides derived from n-terminal heptad repeat (nhr) of the hiv-1 gp41 are generally poor inhibitors of hiv-1 entry, because they tend to aggregate and do not form a trimeric coiled-coil. in this study, we have fused portions of gp41 nhr, e.g. n36 or n28, to the t4 fibritin trimerization domain, foldon (fd), thus constructing novel nhr trimers, designated n36fd or n28fd, which could be expressed in escherichia coli cells. the purified n36fd and n28fd exhibited sds-resistant trimeric coiled-coil ... | 2010 | 20538590 |
| synthesis, biological properties and anti-hiv-1 activity of new pyrimidine p1,p2-dinucleotides. | new homo- and hetero-p(1),p(2)-dinucleotides were prepared with the use of multistep procedures starting from the monophosphates of 3'-fluoro-2-thiothymidine, 3'-fluoro-4-thiothymidine, azt and 1-[(2-hydroxyethoxy)-methyl-5-propyl-6-phenylselenenyl]uracil. anti-hiv properties of the synthesized p(1),p(2)-dinucleotides were evaluated against laboratory syncytia inducing strain hiv-1 in cem-t4 cells. anti-hiv activities were in the range of 5-45 nm, and therapeutic indexes were higher than 4666-14 ... | 2010 | 20544533 |
| determinants of affinity and activity of the anti-sigma factor asia. | the asia protein is a t4 bacteriophage early gene product that regulates transcription of host and viral genes. monomeric asia binds tightly to the sigma(70) subunit of escherichia coli rna polymerase, thereby inhibiting transcription from bacterial promoters and phage early promoters and coactivating transcription from phage middle promoters. results of structural studies have identified amino acids at the protomer-protomer interface in dimeric asia and at the monomeric asia-sigma(70) interface ... | 2010 | 20545305 |
| neutrophil oxidative metabolism and haemogram of sheep experimentally infected with haemonchus contortus and supplemented with selenium and vitamin e. | the objective of this study was to evaluate neutrophil oxidative metabolism and haemogram in sheep experimentally infected with haemonchus contortus and supplemented with selenium and vitamin e. twenty male corriedale sheep were utilised and distributed into four experimental groups each with five animals infected with larvae: g1--supplemented with sodium selenite, 0.2 mg/kg body weight (bw) given intramuscularly (im); g2--supplemented with sodium selenite and vitamin e, 0.2 mg/kg bw and 2000 iu ... | 2010 | 20546075 |
| [oral cancer surgery and oral cutaneous fistulas: risk factors]. | to quantify the oral cutaneous fistulae after surgery and to identify possible risk factors. | 2010 | 20549096 |
| anterior approaches to the cervicothoracic junction: a study on the surgical accessibility of three different corridors based on the ct images. | to determine the location of left brachiocephalic vein (bcv) and tracheal bifurcation (tb) relative to the vertebral levels, and to ascertain the accessibility of three different corridors (c1: between the esophagus and trachea medially and the carotid sheath laterally, c2: between the right bcv and the brachiocephalic artery, and c3: between the ascending aorta and superior vena cava) for preoperative planning. from august 2008 to april 2009, normal chest ct scans of 150 subjects ranging in age ... | 2010 | 20549258 |
| changes in monoterpene emission rates of quercus ilex infested by aphids tended by native or invasive lasius ant species. | the emission of volatile organic compounds (vocs) depends on temperature and light. other factors such as insect herbivory also may modify voc emission. in particular, aphid feeding promotes the release of new compounds and changes the composition of plant volatile blends. given that some aphids are tended by ants, we investigated whether ants change the emission of vocs indirectly through attendance on aphids. the effect of lachnus roboris aphids and two different tending ant species on terpene ... | 2010 | 20549328 |
| brominated diphenyl ether (bde) levels in liver, adipose, and milk from adult and juvenile rats exposed by gavage to the de-71 technical mixture. | brominated diphenyl ethers (bdes) are used as flame retardants in consumer products. rodent studies indicate that the liver, thyroid, and nervous system of developing animals are targets of bdes. to explore the relationship between exposure and health in developing animals, bde accumulation in adult and juvenile rats was examined in conjunction with changes in liver weight and serum thyroxine (t4). adult (f0) rats received the commercial bde mixture de-71 by gavage at doses of 0.5, 5, and 25 mg ... | 2010 | 20549633 |
| sentinel lymph node biopsy for papillary thyroid cancer: 12 years of experience at a single institution. | the purpose of this study was to report our experience with sentinel lymph node dissection (slnd) for papillary thyroid carcinoma, to evaluate the feasibility and safety of the procedure, and to examine its potential utility as a guide for central neck dissection. | 2010 | 20552407 |
| isolation and identification of acanthamoeba species related to amoebic encephalitis and nonpathogenic free-living amoeba species from the rice field. | isolation and characterization of the clinically relevant amphizoic amoebas in vegetated farmlands, which may present a risk to farmers' health. | 2010 | 20553339 |
| altered thyroid hormones and behavioural change in a sub-population of rats following chronic constriction injury. | hypothyroidism is associated with a disturbance of behaviour and mood. there are also individuals, not classified as hypothyroid, with low to 'low normal' thyroid hormone levels and normal thyroid-stimulating hormone (tsh) levels who have mood and behavioural changes. as the peripheral thyroid hormones decrease, tsh is expected to increase. however, there are a number of physiological mechanisms known to suppress tsh. in the present study, we report on thyroid hormone regulation in a rat model o ... | 2010 | 20553369 |
| treatment of cancer-related chest wall pain using spinal cord stimulation. | it has been estimated that 15% to 40% of chronic cancer pain has a neuropathic component, and this type of pain often responds poorly to opioids. in an attempt to provide increased pain relief for patients with intractable cancer pain, unconventional agents and interventional management approaches have received considerable attention. spinal cord stimulation (scs) has been used with increased frequency for the treatment of intractable cancer pain. | 2010 | 20555037 |
| platysma myocutaneous flap for oral cavity reconstruction. | a retrospective study was conducted to assess outcomes of reconstruction of the oral cavity with the platysma myocutaneous flap, in terms of flap survival, complications, and quality of life. included were 10 patients with squamous cell carcinoma (stage t1 to t4; nodal status n0 to n2) of the oral cavity who were treated between 2002 and 2006. each patient underwent tumor resection, modified radical neck dissection, and primary reconstruction with a platysma myocutaneous flap. operating time, le ... | 2010 | 20556740 |
| salvage surgery for local recurrence after chemoradiotherapy or radiotherapy in hypopharyngeal cancer patients. | this retrospective study aimed to assess the role of salvage surgery for local recurrence in hypopharyngeal cancer (hpc) patients who had received radiotherapy (rt) or concomitant chemoradiotherapy (crt) as an initial treatment. the local recurrence rate, salvage rate after local recurrence and overall survival rate were investigated in 104 hpc patients who received treatment between 1991 and 2005. local recurrence in the primary site was observed in 41 patients (rate, 39.4%) of whom only 12 cou ... | 2010 | 20495926 |
| a combined rt-pcr and dot-blot hybridization method reveals the coexistence of sjnnv and rgnnv betanodavirus genotypes in wild meagre (argyrosomus regius). | to detect the possible coexistence of striped jack nervous necrosis virus (sjnnv) and red-spotted grouper nervous necrosis virus (rgnnv) genotypes in a single fish, a methodology based on the combination of pcr amplification and blot hybridization has been developed and applied in this study. | 2010 | 20497277 |
| functional analysis of the highly antigenic outer capsid protein, hoc, a virus decoration protein from t4-like bacteriophages. | bacteriophage t4 is decorated with 155 copies of the highly antigenic outer capsid protein, hoc. the hoc molecule (40 kda) is present at the centre of each hexameric capsomer and provides a good platform for surface display of pathogen antigens. biochemical and modelling studies show that hoc consists of a string of four domains, three immunoglobulin (ig)-like and one non-ig domain at the c-terminus. biochemical data suggest that the hoc protein has two functional modules, a capsid binding modul ... | 2010 | 20497329 |
| better late than early: delayed translation of intron-encoded endonuclease i-tevi is required for efficient splicing of its host group i intron. | the td group i intron interrupting the thymidylate synthase (ts) gene of phage t4 is a mobile intron that encodes the homing endonuclease i-tevi. efficient rna splicing of the intron is required to restore function of the ts gene, while expression of i-tevi from within the intron is required to initiate intron mobility. three distinct layers of regulation temporally limit i-tevi expression to late in the t4 infective cycle, yet the biological rationale for stringent regulation has not been teste ... | 2010 | 20497330 |
| cord blood thyroid-stimulating hormone and free t4 levels in turkish neonates: is iodine deficiency still a continuing problem? | the objectives of this study were to determine the cord blood thyroid-stimulating hormone (tsh) and free t(4) (ft(4) ) levels in turkish neonates and to determine whether these variables reveal iodine deficiency. | 2010 | 20497362 |
| paclitaxel and carboplatin as neoadjuvant chemotherapy in patients with locally advanced breast cancer: a phase ii trial of the hellenic cooperative oncology group. | this phase ii study sought to evaluate the efficacy of the paclitaxel-carboplatin combination as neoadjuvant chemotherapy in patients with locally advanced breast cancer (labc). | 2010 | 20497922 |
| [bacteriophage t4: molecular aspects of bacterial cell infection and the role of capsid proteins]. | bacteriophage t4 of the myoviridae family is ubiquitous in the environment and living organisms. in microbiology it has become a universal research model for the mechanisms of many biological processes, including bacteriophage infection. t4 phage is a tailed phage, the most frequent bacteriophage group. it is made up of a head, a contractile tail, and dsdna. its tail is a complex structure composed of a collar and its whiskers, a tail tube, a base plate, short fibers, and tail fibers. all these ... | 2010 | 20498502 |
| preoperative local staging of esophageal carcinoma using dual-phase contrast-enhanced imaging with multi-detector row computed tomography: value of the arterial phase images. | to evaluate whether the accuracy of local extension (t-staging) of esophageal carcinoma could be improved with addition of arterial phase images by use of multi-detector row computed tomography. | 2010 | 20498545 |
| comprehensive effects of supplemented essential amino acids in patients with severe copd and sarcopenia. | aim of the study was to investigate whether or not oral supplementation of essential amino acids (eaas) may improve body composition, muscle metabolism, physical activity, cognitive function, and health status in a population of subjects with severe chronic obstructive pulmonary disease (copd) and sarcopenia. | 2010 | 20499791 |