Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| serum interleukin (il)-9 and il-10, but not t-helper 9 (th9) cells, are associated with survival of patients with acute-on-chronic hepatitis b liver failure. | cd4 t helper (th) cells are reported to be essential for initiating and maintaining an effective immune response to hepatitis b virus (hbv) infection. th9 cells are a new subset of cd4 th cells that produce interleukin (il)-9 and il-10. the present study aimed to investigate the percentage of th9 cells relative to the number of cd4 cells in peripheral blood. we also measured serum il-9 and il-10 levels in different stages of hbv infection and their relationship with progress and prognosis of liv ... | 2016 | 27100428 |
| discontinuation of oral antivirals in chronic hepatitis b: a systematic review. | the possibility of safe discontinuation of therapy with nucleos(t)ide analogues (nas) remains one of the most controversial topics in the management of chronic hepatitis b. therefore, we systematically reviewed the existing data on na discontinuation in this setting and tried to identify factors affecting the probability of posttherapy remission. a literature search was performed in order to identify all published studies including patients who discontinued nas in virological remission (vr) and ... | 2016 | 27100145 |
| role of mri with hepatospecific contrast agent in the identification and characterization of focal liver lesions: pathological correlation in explanted livers. | to assess the diagnostic performance of magnetic resonance imaging (mri) with gadoxetic acid in the identification of hepatocellular carcinoma (hcc) nodules by comparison with histological findings. | 2016 | 27100719 |
| sorafenib after resection improves the outcome of bclc stage c hepatocellular carcinoma. | to evaluate whether sorafenib use after resection impacts tumor relapse and survival in barcelona clinic liver cancer (bclc) stage c hepatocellular carcinoma (hcc). | 2016 | 27099447 |
| micrornas as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellular-carcinoma. | aim of the present review is to summarize the current knowledge about the potential relationship between mirnas and hepatitis b virus (hbv)-hepatitis c virus (hcv) related liver diseases. a systematic computer-based search of published articles, according to the preferred reporting items for systematic reviews and meta-analysis statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mirnas, as noninvasive biomarkers for early detection of hbv and hcv-induced hep ... | 2016 | 27099435 |
| hepatitis b virus surface antigen activates myeloid dendritic cells via a soluble cd14-dependent mechanism. | hepatitis b virus (hbv) infection can cause chronic liver disease, which is associated with increased risk of liver cirrhosis, liver failure, and liver cancer. clearance of hbv infection requires effective hbv-specific immunity; however, the immunological mechanisms that determine the development of effective hbv-specific immunity are poorly understood. dendritic cells (dc) play a pivotal role in the regulation of antiviral immunity. here, we investigated the interaction between hbv surface anti ... | 2016 | 27099316 |
| reactivation of occult hepatitis b virus infection under treatment with abatacept: a case report. | abatacept (aba) is a fusion receptor protein containing the ctla-4 domain that prevents the activation of naïve t cells by binding the cd80 and cd86 molecules expressed on the surface of dendritic cells, indicated for the treatment of moderate to severe rheumatoid arthritis (ra). there is still little evidence concerning the safety of aba in ra patients with positive serology for hepatitis virus b (hbv) infection. | 2016 | 27098382 |
| [risk factors for short-term outcome of patients with hbv-related acute-on-chronic liver failure]. | to investigate the risk factors for the short-term outcome of patients with hepatitis b virus (hbv)-related acute-on-chronic liver failure (aclf), and to establish a risk model for predicting the short-term outcome of these patients. | 2016 | 27095765 |
| immunity to hepatitis b persists in adolescents 15-16 years of age vaccinated in infancy with three doses of hepatitis b vaccine. | vaccination of infants against hepatitis b virus (hbv) using hepatitis b vaccine is effective in preventing the infection during early childhood and there is a growing evidence of long-term protection. so far, no need for a booster dose has been identified in healthy subjects; however further follow-up continues to determine the exact duration of protection. we evaluated antibody persistence and immune response to a hepatitis b vaccine challenge dose in children aged 15-16 years, previously vacc ... | 2016 | 27095043 |
| hepatitis b and c in children. | the diagnosis and treatment of infection with hepatitis b and c has undergone a paradigm shift in the past decade. although children with these infections are usually asymptomatic with normal liver function, their evaluation and management can often involve complex issues and require specialized expertise. here the authors review the common clinical scenarios which might be encountered by a general pediatrician, explain the various tests available for diagnosis, and provide practical guidelines ... | 2016 | 27094777 |
| a randomized study comparing the efficacy of three hepatitis b vaccine induction regimens in adult patients with hematological malignancies. | non-responsiveness to hepatitis b virus (hbv) vaccines is not rare in hemato-oncological patients due to disease-associated or treatment-induced immune suppression. although different strategies have been employed to improve the response rates, to date there is not an approved schedule for hbv immunization in patients with hematological malignancies. we designed a prospective randomized study to evaluate the efficacy of 3 different induction regimens for hbv vaccination. | 2016 | 27094506 |
| telbivudine versus lamivudine and entecavir for treatment-naïve decompensated hepatitis b virus-related cirrhosis. | the long-term effects of telbivudine (tbv) on decompensated hepatitis b virus (hbv)-related cirrhosis were still not established. this study aimed to investigate the efficacy and safety of tbv in such cohort of patients as compared to lamivudine (lam) and entecavir (etv). we retrospectively evaluated 130 treatment-naïve patients with hbv-related decompensated cirrhosis who started treatment with tbv (n = 31), lam (n = 45) or etv (n = 54). after 24 months of treatment, cumulative virological resp ... | 2016 | 27094312 |
| human hepatocytes express absent in melanoma 2 and respond to hepatitis b virus with interleukin-18 expression. | absent in melanoma 2 (aim2) is a recently recognized cytoplasmic receptor which could sense cytoplasmic double-stranded dna (dsdna). after aim2 detects the presence of parasitic nucleic acids (dsdna) derived from invasive bacteria or viral genomes (for example, vaccinia virus and cytomegalovirus) within infected cells, aim2 inflammasome could be formed. the formed aim2 inflammasome could induce innate immune response and increase expressions of il-1β and il-18. hepatitis b virus (hbv) is a hepat ... | 2016 | 27094165 |
| hbsag positivity during pregnancy and adverse maternal outcomes: a retrospective cohort analysis. | hepatitis b virus infection characterized by hbsag positivity during pregnancy is a well-recognized issue in developing countries, but the association between hbsag positivity and adverse maternal outcomes remains uncertain. to examine the association between hbsag positivity during pregnancy and adverse maternal outcomes, a retrospective cohort study was conducted in sichuan province, china. deliveries were recorded from six hospitals between 1 january 2009 and 31 december 2010. pre-eclampsia, ... | 2016 | 27167604 |
| which is safer source plasma for manufacturing in china: apheresis plasma or recovered plasma? | in most countries, the plasma for derivative production includes two types of plasma, apheresis plasma (ap) and recovered plasma (rp). however, the plasma recovered from whole blood is not permitted for manufacture in china. because of the lack of source plasma and the surplus of rp, the chinese government is considering allowing rp as an equivalent source for the production of plasma derivatives. it is known that human blood can be contaminated by various infectious agents. the objective of the ... | 2016 | 27167358 |
| first case report of renal improvement on tenofovir alafenamide in an hiv/hepatitis b virus-coinfected patient with adefovir-induced fanconi's syndrome. | 2016 | 27167011 | |
| antibodies to hepatitis b virus surface antigen and survival of hemodialysis patients - a prospective study. | antibodies to hepatitis b virus (hbv) surface antigen (anti-hbs) may develop in response to hbv vaccination or infection. we investigated whether anti-hbs are an independent predictor of survival in hemodialysis (hd) patients. | 2016 | 27166852 |
| [efficacy of hepatitis b immunoprophylaxis in children at high risk of hepatitis b and risk factors for mother-to-child transmission of hepatitis b virus]. | to investigate the risk factors for mother-to-child transmission of hepatitis b virus (hbv) and the efficacy of hepatitis b immunoprophylaxis in children at high risk of hepatitis b. | 2016 | 27165589 |
| fatal fulminant hepatitis caused by infection with subgenotype a1 hepatitis b virus with c1766t/t1768a core promoter mutations. | adults initially infected with the hepatitis b virus develop various types of hepatitis ranging from asymptomatic to fulminant, and the clinical course of infection is influenced by a variety of host and viral factors. the viral risk factors associated with fulminant hepatitis reportedly include subgenotype b1, negative hbe antigen, and mutations in the precore and core promoter regions. here, we present a case of fatal fulminant hepatitis caused by infection with subgenotype a1 hepatitis b viru ... | 2016 | 27165167 |
| clinical, demographic, and epidemiologic characteristics of hepatitis b virus-infected patients at a tertiary public hospital in presidente prudente, state of são paulo, brazil. | few studies have addressed the primary characteristics of patients infected with hepatitis b virus (hbv) in the general population, especially those living in small- and medium-sized cities in brazil. we aimed to determine the clinical, demographic, and epidemiologic characteristics of patients diagnosed with hbv who were followed up at an infectious diseases clinic of a public hospital in state of são paulo, brazil. | 2016 | 27163560 |
| hepatitis b reverse seroconversion and transmission in a hemodialysis center: a public health investigation and case report. | in march 2013, public health authorities were notified of a new hepatitis b virus (hbv) infection in a patient receiving hemodialysis. we investigated to identify the source and prevent additional infections. we reviewed medical records, interviewed the index patient regarding hepatitis b risk factors, performed hbv molecular analysis, and observed infection control practices at the outpatient hemodialysis facility where she received care. the index patient's only identified hepatitis b risk fac ... | 2016 | 27161589 |
| loss of confidence in vaccines following media reports of infant deaths after hepatitis b vaccination in china. | china reduced hepatitis b virus (hbv) infection by 90% among children under 5 years old with safe and effective hepatitis b vaccines (hepb). in december 2013, this success was threatened by widespread media reports of infant deaths following hepb administration. seventeen deaths and one case of anaphylactic shock following hbv vaccination had been reported. | 2016 | 27174834 |
| study on 2-arylthio-5-iodo pyrimidine derivatives as novel nonnucleoside inhibitors against hepatitis b virus dna replication. | novel nonnucleoside hepatitis b virus inhibitors have been recently developed for the reason of drug-resistant mutations and adverse effects of nucleoside analogs. in this study, two series of 2-arylthio-5-iodo pyrimidine analogs were firstly reported as potential anti-hbv agents. | 2016 | 27172826 |
| acute-on-chronic liver failure: the role of precipitating illness. | acute-on-chronic liver failure (aclf) is a complex syndrome that develops in patients with cirrhosis at any stage during the natural history of the disease. in most cases, the development of aclf is associated with an identifiable precipitating factor. overall, the most common precipitating events are bacterial infections. although data suggest that any type of infection may trigger aclf, spontaneous bacterial peritonitis, secondary peritonitis, and pneumonia appear to be the most common types o ... | 2016 | 27172352 |
| hepatitis b surface antibodies in medical students from a public university in puebla, mexico. | although preventable with vaccination, hepatitis b virus (hbv) infection is a major health concern, with ∼400 million people at risk of developing the chronic form of the disease worldwide. the anti-hbv vaccine consists of a recombinant hbv surface antigen (hbsag), which induces specific anti-hbs antibodies and confers 95% protection for >20 y. the aim of the present study was to analyze the response to hbv vaccination by measuring anti-hbs antibodies in serum samples from medical students of a ... | 2016 | 27171749 |
| brief report: efficacy and safety of switching to a single-tablet regimen of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in hiv-1/hepatitis b-coinfected adults. | coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide (e/c/f/taf) has high efficacy and improved renal and bone safety in multiple phase 3 trials; taf single agent is being studied in 2 phase 3 trials in patients with chronic hepatitis b. we report the results of an open-label, noncomparative switch study evaluating the efficacy and safety of e/c/f/taf in hiv/hepatitis b virus (hbv)-coinfected adults. at 48 weeks, 91.7% of the 72 participants maintained or achieved viro ... | 2016 | 27171740 |
| re-designed recombinant hepatitis b virus vectors enable efficient delivery of versatile cargo genes to hepatocytes with improved safety. | hepatitis b virus (hbv) takes humans as its sole natural host, and productive infection in vivo is restricted exclusively to hepatocytes in the liver. consequently, hbv-derived viral vectors are attractive candidates for liver-targeting gene therapies. previously, we developed a novel recombinant hbv vector, designated 5c3c, from a highly replicative clinical isolate. 5c3c was demonstrated to be capable of efficiently delivering protein or rna expression into infected primary tupaia hepatocytes ... | 2016 | 27171107 |
| inhibition of hepatitis b virus replication by a dntpase-dependent function of the host restriction factor samhd1. | samhd1 is a cellular protein that possesses dntpase activity and inhibits retroviruses and dna viruses through the depletion of cellular dntps. however, recent evidence suggests the existence of alternative or additional mechanisms that involve novel nuclease activities. hepatitis b virus is a dna virus but resembles retroviruses in that its dna genome is synthesized via reverse transcription of an rna transcript. samhd1 was shown to inhibit the expression and replication of a transfected hbv dn ... | 2016 | 27179347 |
| fatty acid biosynthesis is involved in the production of hepatitis b virus particles. | hepatitis b virus (hbv) proliferates in hepatocytes after infection, but the host factors that contribute to the hbv lifecycle are poorly understood at the molecular level. we investigated whether fatty acid biosynthesis (fabs), which was recently reported to contribute to the genomic replication of hepatitis c virus, plays a role in hbv proliferation. we examined the effects of inhibitors of the enzymes in the fabs pathway on the hbv lifecycle by using recombinant hbv-producing cultured cells a ... | 2016 | 27178211 |
| two-step forward genetic screen in mice identifies ral gtpase-activating proteins as suppressors of hepatocellular carcinoma. | high-throughput sequencing technologies have identified thousands of infrequently mutated genes in hepatocellular carcinomas (hccs). however, high intratumor and intertumor heterogeneity, combined with large numbers of passenger mutations, have made it difficult to identify driver mutations that contribute to the development of hcc. we combined transposon mutagenesis with a high-throughput screen of a small-hairpin rna (shrna) library to identify genes and pathways that contribute to hcc develop ... | 2016 | 27178121 |
| genome-wide association study identified plce1- rs2797992 and egfr- rs6950826 were associated with tp53 expression in the hbv-related hepatocellular carcinoma of chinese patients in guangxi. | the genome-wide association approach was employed to explore the association between single nucleotide polymorphisms (snps) and tp53 expression in the hbv-related hepatocellular carcinoma (hcc) of chinese patients in guangxi. | 2016 | 27186304 |
| the combination of tacrolimus and entecavir improves the remission of hbv-associated glomerulonephritis without enhancing viral replication. | tacrolimus inhibits hepatitis b virus entry into hepatocytes through targeting the hbv receptor, sodium taurocholate cotransporting polypeptide. this study was performed to evaluate the efficacy and safety of tacrolimus combined with entecavir antiviral therapy for hbv-associated glomerulonephritis patients with biopsy-proven membranous nephropathy. | 2016 | 27186284 |
| high prevalence of chronic hepatitis d virus infection in eastern turkey: urbanization of the disease. | both hepatitis b virus (hbv) and hepatitis d virus (hdv) infection play an increasingly important role in liver diseases. the main objective of this study was to investigate the socio-epidemiological, laboratory and radiological aspects of both hbv and hdv infection near the iranian border of turkey. | 2016 | 27186189 |
| establishment of an inducible hbv stable cell line that expresses cccdna-dependent epitope-tagged hbeag for screening of cccdna modulators. | hepatitis b virus (hbv) covalently closed circular (ccc) dna is essential to the virus life cycle, its elimination during chronic infection is considered critical to a durable therapy but has not been achieved by current antivirals. despite being essential, cccdna has not been the major target of high throughput screening (hts), largely because of the limitations of current hbv tissue culture systems, including the impracticality of detecting cccdna itself. in response to this need, we have prev ... | 2016 | 27185623 |
| prevention strategies for blood-borne viruses-in the era of vaccines, direct acting antivirals and antiretroviral therapy. | blood-borne viruses, such as hepatitis b virus, hepatitis c virus, human immunodeficiency virus, and the facultative blood-borne hepatitis e virus, are considered a major public health problem given that they are accountable for millions of deaths each year. treatment options, including effective vaccine design, development of antiviral strategies and the implementation of antiretroviral therapy have improved substantially over the last couple of years and contribute to successful treatment and ... | 2016 | 27185010 |
| fulminant hepatitis b virus reactivation following antiviral treatment interruption in a chronically infected patient. | 2016 | 27184688 | |
| nk cells help induce anti-hepatitis b virus cd8+ t cell immunity in mice. | although recent clinical studies demonstrate that nk cell function is impaired in hepatitis b virus (hbv)-persistent patients, whether or how nk cells play a role in anti-hbv adaptive immunity remains to be explored. using a mouse model mimicking acute hbv infection by hydrodynamic injection of an hbv plasmid, we observed that although serum hepatitis b surface ag and hepatitis b envelope ag were eliminated within 3 to 4 wk, hbv might persist for >8 wk in cd8(-/-) mice and that adoptive transfer ... | 2016 | 27183639 |
| genetic diversity of hepatitis b virus (hbv) in madagascar. | hepatitis b virus (hbv) is a dna virus belonging to hepadnaviridae family. chronic infection with hbv is one major risk factor of hepatic disease. in madagascar, former studies classified the country as part of high endemic area, as hbv prevalence can reach 23% in general population. however, this prevalence differs largely between urban and rural areas and is estimated to be, respectively, 5% and 26%. the aims of the present study were to describe the genetic diversity of hbv strains from diffe ... | 2016 | 27183503 |
| characterization of novel hepatitis b virus pres/s-gene mutations in a patient with occult hepatitis b virus infection. | the impact of hepatitis b virus (hbv) pres/s-gene mutations on occult hbv infection (obi) is not fully understood. this study characterized multiple novel hbv pres/s-gene mutants obtained from an obi patient. | 2016 | 27182775 |
| histologic disease in chinese chronic hepatitis b patients with low viral loads and persistently normal alanine aminotransferase levels. | we aimed to evaluate the histopathologic characteristics of hbeag-negative chronic hepatitis b patients with low hepatitis b virus (hbv) dna levels (<2000 iu/ml) and persistently normal alt levels and to determine indicators of significant liver disease. | 2016 | 27182648 |
| expression of b7-h4 and hepatitis b virus x in hepatitis b virus-related hepatocellular carcinoma. | to investigate the expression and clinical significance of b7-h4 and hepatitis b virus x (hbx) protein in hepatitis b virus-related hepatocellular carcinoma (hbv-hcc). | 2016 | 27182163 |
| hepatitis b virus reactivation following salazosulfapyridine monotherapy in a patient with rheumatoid arthritis. | a 72-year-old man was diagnosed with rheumatoid arthritis (ra) and prior hepatitis b virus (hbv) infection. he began treatment with salazosulfapyridine (sasp). several months later, his blood tests reflected a slightly elevated liver function. serum tests were positive for hepatitis b surface antigen and hbv-dna, and the diagnosis of de novo hbv hepatitis was made. a genetic analysis showed that he had polymorphisms of abcg2 and nat2, which could lead to high plasma concentrations of sasp and su ... | 2016 | 27181550 |
| elevation of the hepatitis b virus dna during the treatment of polycythemia vera with the jak kinase inhibitor ruxolitinib. | ruxolitinib is a useful treatment option for myelofibrosis since it effectively resolves splenomegaly and constitutional symptoms. after the widespread use of ruxolitinib outside of clinical trials, a series of case reports indicated a potential risk of ruxolitinib-associated opportunistic infections, including the reactivation of the hepatitis b virus (hbv). we herein report the case of a polycythemia vera patient who showed an elevation of hbv-dna viral dna with an elevation of aspartate amino ... | 2016 | 27181544 |
| relevance of serum interleukin-33 and st2 levels and the natural course of chronic hepatitis b virus infection. | interleukin-33 (il-33) and st2 have been demonstrated to be associated with liver damage. however, their potential value in hepatitis b virus (hbv) infection remains unknown. this study was designed to investigate the change of serum il-33 and st2 levels in the natural course of chronic hbv infection. | 2016 | 27180842 |
| the effect of rituximab dose on infectious complications in abo-incompatible kidney transplantation. | rituximab (rit) improves the outcomes of abo-incompatible (aboi) kidney transplantation (kt), but it has been associated with infectious complications. the aim of this study was to investigate infectious complications according to the dose of rit in aboi kt. | 2016 | 27190360 |
| eradication strategies for chronic hepatitis b infection. | chronic hepatitis b infection affects >300 million people worldwide and is a leading cause of liver failure and cancer. current approaches to treatment for chronic hepatitis b involve suppression of hepatitis b virus (hbv) dna with the use of nucleoside analogues. chronic suppressive therapy rarely results in a "functional cure" or absence of detectable hbv dna in plasma and loss of detectable hepatitis b surface antigen after cessation of therapy. the major obstacles to achieving a functional c ... | 2016 | 27190322 |
| hepatitis b in pregnancy. | chronic hepatitis b virus (hbv) infection is estimated to affect >350 million people worldwide and represents a significant cause of morbidity and mortality related to cirrhosis and hepatocellular carcinoma. mother-to-child transmission (mtct) of hbv remains an important source of incident cases of hbv. current barriers to eradication of incident hbv infections via mtct include underutilization of immunoprophylaxis with hepatitis b vaccination and hepatitis b immune globulin in certain endemic r ... | 2016 | 27190321 |
| hepatitis b virus reactivation in the setting of cancer chemotherapy and other immunosuppressive drug therapy. | hepatitis b virus reactivation (hbvr) is an important complication of immunosuppressive drug therapy (isdt). it can occur with active or resolved hepatitis b virus (hbv) infection with a clinical spectrum that ranges from mild elevations in liver tests to fulminant hepatic failure. the risk of it occurring is determined by the interplay between hbv serological status, level of viremia, and the immunosuppressive potency of the drug(s) used. reactivation is most common during treatment of hematolo ... | 2016 | 27190320 |
| virus and host testing to manage chronic hepatitis b. | chronic hepatitis b virus (hbv) infection is a major cause of cirrhosis and hepatocellular carcinoma worldwide. the past 50 years have seen rapid developments in hbv testing. beginning from traditional serologic tests, the availability of sensitive hbv dna assays allows a thorough understanding of the virology and natural history of chronic hbv infection. quantification of hepatitis b surface antigen levels reflects the amount and transcriptional activities of covalently closed circular dna in t ... | 2016 | 27190319 |
| a novel collaborative community-based hepatitis b screening and linkage to care program for african immigrants. | sub-saharan african nations have among the highest rates of chronic hepatitis b virus (hbv) infection worldwide, but little is known about hbv infection in african-born persons in the united states. | 2016 | 27190318 |
| mechanism of hepatitis b virus persistence in hepatocytes and its carcinogenic potential. | liver disease associated with persistent infection with hepatitis b virus (hbv) continues to be a major health problem of global impact. despite the existence of an effective vaccine, at least 240 million people are chronically infected worldwide, and are at risk of developing liver cirrhosis and hepatocellular carcinoma. although chronic hbv infection is considered the main risk factor for liver cancer development, the molecular mechanisms determining persistence of infection and long-term path ... | 2016 | 27190317 |
| original research: analysis of hepatic microrna alterations in response to hepatitis b virus infection and pegylated interferon alpha-2a treatment. | interferons play important roles in defense mechanisms against viral infection, and thus interferon therapy has been a standard treatment in chronic hepatitis b patients. interferons signaling pathways promote interferon-inducible genes including micrornas. in this research, we aimed to determine micrornas expression profiles in vitro and in vivo for in vitro model, huh7 cells were transfected with or without hepatitis b virus plasmid for 6 h, and then treated with 100 ng of pegylated-interferon ... | 2016 | 27190255 |
| dually active hiv/hbv antiretrovirals as protection against incident hepatitis b infections: potential for prophylaxis. | hepatitis b virus (hbv) has a detrimental effect on human immunodeficiency virus (hiv) natural course, and hbv vaccination is less effective in the hiv infected. we examine the protective effect of dually active antiretroviral therapy (daart) for hiv/hbv (tenofovir, lamivudine, and emtricitabine) in a large cohort encompassing heterosexuals, men who have sex with men, and intravenous drug users who are hiv infected yet susceptible to hbv, with comprehensive follow-up data about risky behavior an ... | 2016 | 27190182 |
| hepatitis b virus replication in cd34+ hematopoietic stem cells from umbilical cord blood. | background hepatitis b virus (hbv) is a hepatotropic virus that can infect extrahepatic tissue. whether hematopoietic stem cells (hscs) can be infected by hbv and serve as a potential virus reservoir is still unknown. in this study, the susceptibility of cd34+ hscs to hbv was investigated. material and methods cord blood-derived cd34+ hscs were exposed to hbv in vitro, and immunocytochemistry, transmission electron microscopy, and rt-pcr were used to identify viral-related proteins and specific ... | 2016 | 27188537 |
| evaluation of human t-lymphotropic virus prevalence/co-infection rates for a four-year period in a non-metropolitan blood center in southeast brazil. | human t-lymphotropic virus types 1/2 (htlv-1/2) are distributed worldwide and are endemic in specific regions. | 2016 | 27192594 |
| offspring's tolerance of mother goes viral. | pregnancy uniquely allows genetically discordant tissues of the mother and child to intimately coexist in harmony. in this issue of immunity, ou and colleagues show that hepatitis b virus exploits these naturally occurring immune tolerance pathways to establish persistent postnatal infection in offspring. | 2016 | 27192574 |
| combined acoustic radiation force impulse, aminotransferase to platelet ratio index and forns index assessment for hepatic fibrosis grading in hepatitis b. | to investigate the combined diagnostic accuracy of acoustic radiation force impulse (arfi), aspartate aminotransferase to platelet ratio index (apri) and forns index for a non-invasive assessment of liver fibrosis in patients with chronic hepatitis b (chb). | 2016 | 27190578 |
| prevalence of hiv and hepatitis b coinfection in ghana: a systematic review and meta-analysis. | human immunodeficiency virus (hiv) and hepatitis b virus (hbv) coinfection has been associated with higher morbidity and mortality and may impact significantly on healthcare resource utilization. however, in ghana, accurate estimates of the prevalence of hiv/hbv coinfection needed to inform policy decisions and the design of public health interventions are currently lacking. in this study, our aim was to determine the hiv/hbv coinfection prevalence rate in ghana. | 2016 | 27190544 |
| influence of preoperative sodium concentration on outcome of patients with hepatitis b virus cirrhosis after liver transplantation. | whether preoperative serum sodium concentration could influence post-transplant patients' prognosis remains controversial. the aim of this study was to evaluate the influence of patients' pretransplant sodium concentration on the prognosis after liver transplantation in a cohort of patients with hepatitis b virus-related cirrhosis. | 2016 | 27362549 |
| impact of weight reduction program on serum alanine aminotransferase activity and immunologic response in obese hepatitis b patients. | globally, chronic b viral hepatitis (hbv) is a major health problem. obesity is a common problem among patients with hbv. several studies have reported that obesity is an important risk factor that alters immune system response in individuals with no underlying cause of liver disease. however, there is a strong association between bmi and the human immune system among hbv patients. | 2016 | 27358623 |
| incidence and clinical background of hepatitis b virus reactivation in multiple myeloma in novel agents' era. | there are some reports regarding hepatitis b virus (hbv) reactivation in patients with myeloma who are hbv carriers or who have had a resolved hbv infection, and there is no standard prophylaxis strategy for these patients. we performed a retrospective multicenter study to determine the incidence and characteristics of hbv reactivation in patients with multiple myeloma. we identified 641 patients with multiple myeloma who had been treated using novel agents and/or autologous stem cell transplant ... | 2016 | 27358178 |
| dimeric matrine-type alkaloids from the roots of sophora flavescens and their anti-hepatitis b virus activities. | six unusual matrine-type alkaloid dimers, flavesines a-f (1-6, respectively), together with three proposed biosynthetic intermediates (7-9) were isolated from the roots of sophora flavescens. compounds 1-5 were the first natural matrine-type alkaloid dimers, and compound 6 represented an unprecedented dimerization pattern constructed by matrine and (-)-cytisine. their structures were elucidated by nmr, ms, single-crystal x-ray diffraction, and a chemical method. the hypothetical biogenetic pathw ... | 2016 | 27352066 |
| five-year results of oral antiviral therapy in hbeag-negative chronic hepatitis b. | several guidelines recommend the use of tenofovir or entecavir as the first-line treatment for hepatitis b due to the lower resistance rates of these drugs than lamivudine, although lamivudine may still be preferred because of its low adverse effect profile and cost. it is important to know which patients might benefit from lamivudine as the first-line treatment. we aimed to assess the success rates of lamivudine, entecavir, and tenofovir, as well as the resistance rates, frequencies of hbsag cl ... | 2016 | 27210786 |
| emerging therapeutics and relevant targets for chronic hepatitis b. | chronic hepatitis b virus (hbv) infection is a global health problem for the pursuit of complete virus eradication and immunity acquisition to prevent liver disease progression. currently, interferon-alpha, with the underlying mechanism of host immunomodulation, and nucleos(t)ide analogs, with the underlying mechanism of inhibition of viral replication, are used for the treatment of patients with chronic hepatitis b. despite remarkable improvement in the virological, serological, biochemical, an ... | 2016 | 27210776 |
| decay of ccc-dna marks persistence of intrahepatic viral dna synthesis under tenofovir in hiv-hbv co-infected patients. | in the presence of highly-potent antivirals, persistence of hepatitis b virus (hbv) is most well-characterized by covalently-closed circular dna (cccdna) and total intrahepatic dna (ih-dna). we sought to determine how antiviral therapy could affect their levels during human immunodeficiency virus (hiv)-hbv co-infection. | 2016 | 27210429 |
| randomized phase ii study of gs-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis b. | gs-4774 is a heat-inactivated, yeast-based, t-cell vaccine designed to elicit hepatitis b virus (hbv)-specific t-cell responses. we evaluated the safety, tolerability and efficacy of gs-4774 in patients with chronic hbv infection. | 2016 | 27210427 |
| hepatitis b virus inhibits intrinsic rig-i and rig-g immune signaling via inducing mir146a. | previous studies showed that hepatitis b virus (hbv), as a latency invader, attenuated host anti-viral immune responses. mirnas were shown to be involved in hbv infection and hbv-related diseases, however, the precise role of mirnas in hbv-mediated immunosuppression remains unclear. here, we observed that down-regulated rig-i like receptors might be one critical mechanism of hbv-induced suppression of type i ifn transcription in both hbv(+) hepatoma cell lines and liver cancer tissues. then, mir ... | 2016 | 27210312 |
| natural killer cells contribute to hepatic injury and help in viral persistence during progression of hepatitis b e-antigen-negative chronic hepatitis b virus infection. | hepatitis b e-antigen negative (e(-)) chronic hbv infection (chi) encompasses a heterogeneous clinical spectrum ranging from inactive carrier (ic) state to e(-) chronic hepatitis b (chb), cirrhosis and hepatic decompensation. in the backdrop of dysfunctional virus-specific t cells, natural killer (nk) cells are emerging as innate effectors in chi. we characterized cd3(-) cd56(+) nk cells in clinically well-defined, treatment-naive e(-) patients in ic, e(-)chb or decompensated liver cirrhosis (lc ... | 2016 | 27208430 |
| seroprevalence of hepatitis b and c among domestic and healthcare waste handlers in belo horizonte, brazil. | infection with the hepatitis b and c viruses may occur through contact with infected body fluids, including injury with infected sharps. collectors of domestic or healthcare wastes are potentially exposed to these infections. the aim of this article is to investigate the risk factors associated with the prevalence of hepatitis b and c viruses (hbv and hcv) infection among domestic and healthcare waste workers in belo horizonte, brazil. a cross-sectional study of hepatitis b and c infection was c ... | 2016 | 27207769 |
| graves' hyperthyroidism accompanied with acute hepatitis b virus infection: an extrahepatic manifestation? | although hepatitis b virus (hbv) primarily affects hepatocytes, it has also been shown to cause complications in the skin, joints, muscles, and kidneys. thyroid dysfunction is uncommon in cases of acute hbv infection. | 2016 | 27206523 |
| survey of hepatitis b knowledge and stigma among chronically infected patients and uninfected persons in beijing, china. | hepatitis b virus (hbv) infection carries substantial stigma in china. we surveyed hbv knowledge and stigma among chronic hepatitis b (chb) patients and persons without hbv infection in beijing, china. | 2016 | 27206379 |
| complete spectrum of crispr/cas9-induced mutations on hbv cccdna. | hepatitis b virus (hbv) causes chronic infections that cannot yet be cured. the virus persists in infected hepatocytes, because covalently closed circular dna (cccdna), the template for the transcription of viral rnas, is stable in nondividing cells. antiviral therapies with nucleoside analogues inhibit hbv dna synthesis in capsids in the cytoplasm of infected hepatocytes, but do not destroy nuclear cccdna. because over 200 million people are still infected, a cure for chronic hepatitis b (chb) ... | 2016 | 27203444 |
| subclinical ascites does not affect the long-term prognosis in hepatitis b virus-related cirrhosis patients receiving antivirals. | this study evaluated the clinical significance of subclinical ascites in patients with hepatitis b virus-related cirrhosis treated with lamivudine (lmv) or entecavir (etv). | 2016 | 27203430 |
| quantitative assessment of mutations in hepatitis b virus genome with liver cirrhosis and hepatocellular carcinoma development. | the long-term outcomes of liver cirrhosis (lc) and hepatocellular carcinoma (hcc) in patients with chronic hepatitis b virus (hbv) infection are associated with specific hbv genotypes and mutations in the virus genome. however, a number of gene-disease association studies have yielded inconsistent results in the field. to investigate this inconsistency, we conducted a meta-analysis from 118 studies involving a total of 9,418 hcc cases, 2,697 lc cases, and 18,785 hbv-infected participants for 11 ... | 2016 | 27203218 |
| lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis b virus-associated hepatocellular carcinoma patients after curative hepatectomy. | lymphocytes are an integral part of lymphocyte to monocyte ratio (lmr) and prognostic nutritional index (pni). both lmr and pni which reflect body's inflammatory and nutritional status can be obtained from routine blood and biochemical test conveniently. little evidence concerning the prognostic value of lmr and pni in hepatocellular carcinoma (hcc) patients has been published. this study aimed to investigate the prognostic value of lmr and pni in hepatitis b virals (hbv)-associated hcc patients ... | 2016 | 27199001 |
| review article: long-term safety of nucleoside and nucleotide analogues in hbv-monoinfected patients. | nucleos(t)ide analogues (nucs) for chronic hepatitis b treatment achieve high rates of viral suppression and are generally well tolerated. entecavir (etv) and tenofovir disoproxil fumarate (tdf) are the currently preferred first-line agents. the safety of these agents in clinical practice is particularly relevant since long-term treatment is usually required. | 2016 | 27198929 |
| fluctuation of viremia in hepatitis b virus-infected healthcare workers performing exposure-prone procedures in the netherlands. | to determine the longitudinal changes in viral load of hepatitis b virus (hbv)-infected healthcare workers (hcws) and its consequences for exclusion of infected hcws performing exposure-prone procedures, various hbv dna safety thresholds, and the frequency of monitoring. | 2016 | 27198603 |
| prevention of perinatal transmission of hepatitis b virus: assessment among wisconsin maternity hospitals. | to evaluate the completeness of identification of pregnant women testing positive for hepatitis b surface antigen (hbsag) and birth dose hepatitis b vaccine administration, and the extent of appropriate prophylaxis of infants born to women with and without maternal hbsag status documented in the infant medical record. | 2016 | 27197340 |
| statin-induced liver injury in an area endemic for hepatitis b virus infection: risk factors and outcome analysis. | statin-induced liver injury (sili) is quite rare, but may be severe. little is known about the impact of chronic hepatitis b infection (chbi) on sili. we aimed to investigate the risk factors and outcome of sili, with special reference to its interaction with chbi. | 2016 | 27197051 |
| barriers to timely administration of birth dose vaccines in the gambia, west africa. | although vaccine coverage in infants in sub-saharan africa is high, this is estimated at the age of 6-12 months. there is little information on the timely administration of birth dose vaccines. the objective of this study was to assess the timing of birth dose vaccines (hepatitis b, bcg and oral polio) and reasons for delayed administration in the gambia. | 2016 | 27195759 |
| an evaluation of entecavir treatment among nucleos(t)ide-naïve moroccan patients with chronic hepatitis b. | to analyse the efficacy and safety of entecavir (etv) treatment in nucleos(t)ide (nuc)-naïve moroccan patients with chronic hepatitis b. | 2016 | 27195127 |
| multiplex reverse transcriptase-pcr for simultaneous detection of hepatitis b, c, and e virus. | the hepatitis b virus (hbv), hcv, and hev may occur as singly or concurrently in patients of different kind of liver disease. the rapid, reliable, and cost-effective screening of these pathogens is required for the large epidemiological studies. therefore, a study has been planned to develop a multiplex reverse transcriptase-pcr assay which can be used for the screening of maximum number of pathogens at a time. | 2016 | 27194894 |
| acute-on-chronic liver failure (aclf) in coastal eastern india: "a single-center experience". | acute-on-chronic liver failure (aclf) is an emerging entity. the present study was undertaken to analyze the clinical profile and natural course of aclf patients. | 2016 | 27194893 |
| impact of adjuvants on cd4(+) t cell and b cell responses to a protein antigen vaccine: results from a phase ii, randomized, multicenter trial. | immunogenicity and safety of different adjuvants combined with a model antigen (hbsag) were compared. healthy hbv-naïve adults were randomized to receive hbs adjuvanted with alum or adjuvant systems as01b, as01e, as03a or as04 at days 0 and 30. different frequencies of hbs-specific cd4+ t cells 14days post dose 2 but similar polyfunctionality profiles were induced by the different adjuvants with frequencies significantly higher in the as01b and as01e groups than in the other groups. antibody con ... | 2016 | 27236001 |
| hepatitis b virus enhances cisplatin-induced hepatotoxicity via a mechanism involving suppression of glucose-regulated protein of 78 kda. | cisplatin is a classical platinum-based chemotherapeutic drug used in the treatment of many cancer types, including hepatocellular carcinoma (hcc). the application of cisplatin is significantly limited by its toxicity, which may be affected by various biological factors. persistence of hepatitis b virus (hbv) infection leads to hcc development and may be associated with higher incidence of severe hepatitis during chemotherapy. however, whether hbv alters the susceptibility of hepatocytes to cisp ... | 2016 | 27234046 |
| transmission of blood-borne pathogens in us dental health care settings: 2016 update. | during the past decade, investigators have reported transmissions of blood-borne pathogens (bbps) in dental settings. in this article, the authors describe these transmissions and examine the lapses in infection prevention on the basis of available information. | 2016 | 27233680 |
| sarcopenia and two types of presarcopenia in japanese patients with chronic liver disease. | the frequency of sarcopenia, defined as loss of both muscle volume and strength, was analyzed in chronic liver disease (cld). | 2016 | 27232361 |
| nomograms for survival prediction in patients undergoing liver resection for hepatitis b virus related early stage hepatocellular carcinoma. | the long-term outcomes of patients who underwent liver resection (lr) for early-stage hepatitis b virus (hbv)-related hepatocellular carcinomas (hccs) are difficult to predict. this study aimed to develop two nomograms to predict postoperative disease-free survival (dfs) and overall survival (os), respectively. | 2016 | 27232330 |
| restrictive influence of samhd1 on hepatitis b virus life cycle. | deoxynucleotide triphosphates (dntps) are essential for efficient hepatitis b virus (hbv) replication. here, we investigated the influence of the restriction factor samhd1, a dntp hydrolase (dntpase) and rnase, on hbv replication. we demonstrated that silencing of samhd1 in hepatic cells increased hbv replication, while overexpression had the opposite effect. samhd1 significantly affected the levels of extracellular viral dna as well as intracellular reverse transcription products, without affec ... | 2016 | 27229711 |
| [molecular biology of hepatitis b virus and immunopathogenesis of chronic viral hepatitis b]. | chronic hepatitis b belongs to a category of socially significant diseases due to its wide abundance in the world and high frequency of unfavourable outcomes of this disease. features of interaction of hepatitis b virus with human immune system, accompanying development of mechanisms of escape from immunological control, is the basis of development of chronic hepatitis b. molecular-biological features of hepatitis b virus are the basis of the indicated mechanisms, and the content of this review ... | 2016 | 27228681 |
| progressive accumulation of mutations in the hepatitis b virus genome and its impact on time to diagnosis of hepatocellular carcinoma. | to evaluate how hepatitis b virus (hbv) genetic variation affected progression from chronic carrier state to hepatocellular carcinoma (hcc), we analyzed hbv full-length sequences in blood obtained <1-20 years before diagnosis from 117 hcc cases and 118 controls nested in a cohort of 4,841 hbv carriers, for whom hbv genotypes b and c are predominant. the relationship between each viral single-nucleotide polymorphism (snp) and hcc development was assessed using ordinal logistic models according to ... | 2016 | 27228506 |
| pretransplant hepatitis b viral infection increases risk of death after kidney transplantation: a multicenter cohort study in korea. | clinical outcomes in kidney transplant recipients (ktrs) with hepatitis b virus (hbv) have not been thoroughly evaluated. here, we investigated recent posttransplant clinical outcomes of ktrs with hbv and compared them with ktrs with hepatitis c virus (hcv) and seronegative ktrs.of 3855 ktrs from april 1999 to december 2011, we enrolled 3482 ktrs who had viral hepatitis serology data; the patients were followed up for 89.1 ± 54.1 months. the numbers of recipients with hbv and hcv were 160 (4.6%) ... | 2016 | 27227927 |
| the hbsag prevalence among blood donors from eastern mediterranean and middle eastern countries: a systematic review and meta-analysis. | the world health organization (who) recommends that all blood donations should be screened for evidence of infections, such as hepatitis b. the present study aimed to determine the prevalence of hepatitis b surface antigen (hbsag) in blood donors at the eastern mediterranean region office (emro) of the who and middle eastern countries. | 2016 | 27226804 |
| relative importance of hepatitis b and c viruses in hepatocellular carcinoma in emro countries and the middle east: a systematic review. | hepatocellular carcinoma (hcc) is the second most common cancer-related death worldwide. although many factors including dietary aflatoxin b1 (afb1) and alcoholic and non-alcoholic fatty liver diseases can lead to hcc, globally most hcc cases are due to hepatitis b virus (hbv) and hepatitis c virus (hcv). considering the importance of these viral factors in most hcc cases and relative lack of literature from eastern mediterranean region office of world health organization (emro) countries and th ... | 2016 | 27226803 |
| characterization of occult hepatitis b infection among injecting drug users in tehran, iran. | hepatitis b virus (hbv) infection is a major health problem worldwide. | 2016 | 27226802 |
| the correlation between interferon lambda 3 gene polymorphisms and susceptibility to hepatitis b virus infection. | cytokines are proteins that mediate innate and adaptive immunity responses. it is hypothesized that interferon lambda 3 (ifnl3) levels can influence the outcome of chronic hepatitis b virus (hbv) infection. polymorphisms in ifn genes have been associated with response to infection. | 2016 | 27226800 |
| the prevalence of hepatitis b virus among municipal solid waste workers: necessity for immunization of at-risk groups. | hepatitis b virus (hbv) is likely to be more prevalent in certain populations and occupational groups, such as municipal solid waste workers (mswws). | 2016 | 27226797 |
| characterization of the inflammasome in human kupffer cells in response to synthetic agonists and pathogens. | the liver is the largest gland in the human body and functions as an innate immune organ. liver macrophages called kupffer cells (kc) constitute the largest group of macrophages in the human body. innate immune responses involving kc represent the first line of defense against pathogens in the liver. human monocyte-derived macrophages have been used to characterize inflammasome responses that lead to the release of the proinflammatory cytokines il-1β and il-18, but it has not yet been determined ... | 2016 | 27226092 |
| [hepatitis b virus and chromatin remodeling: hbx counteracts setdb1/hp1/h3k9me3 transcriptional silencing]. | 2016 | 27225916 | |
| awareness of hepatitis 'b' among people of khyber pakhtunkhwa province of pakistan. | hepatitis b virus is causing serious health concerns in countries like pakistan. in khyber pakhtunkhwa province, 0.6 milion people were estimated to be infected with this virus in 2008. the authors aimed to assess knowledge regarding vaccination, testing and routes of transmission of hepatitis b virus among people of khyber pakhtunkhwa, as such knowledge among masses will help limit the infection. people belonging to 12 different districts of khyber pakhtunkhwa province were interviewed over a p ... | 2016 | 27225157 |