Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| programmed death-ligand 1 expression, microsatellite instability, epstein-barr virus, and human papillomavirus in nasopharyngeal carcinomas of patients from the philippines. | most nasopharyngeal carcinomas (npcs) in a high-incidence population are driven by epstein-barr virus (ebv) infection. ebv-associated malignancies have increased expression of the programmed death-ligand 1 (pd-l1). immunotherapy agents targeting the pd-1/pd-l1 pathway have achieved durable treatment effects in patients with various cancer types including ebv-associated malignancies. in this study, we sought to investigate pd-l1 expression in a cohort of patients with npcs from the philippines. f ... | 2016 | 27807760 |
| aggressive b-cell lymphomas: frequency, immunophenotype, and genetics in a reference laboratory population. | diffuse large b-cell lymphoma (dlbcl) is the most common type of lymphoma worldwide. the current world health organization classification includes several subtypes based on a combination of clinical, immunohistochemical, and genetic differences. other aggressive variants of b-cell lymphomas, including burkitt lymphoma and double-hit lymphomas are part of the differential diagnosis and often have overlapping features with dlbcl. in this study, we evaluated 760 of cases of dlbcl and other aggressi ... | 2016 | 27806850 |
| lymphoepithelioma-like carcinoma of breast-evaluation for epstein-barr virus-encoded rna, human papillomavirus, and markers of basal cell differentiation. | this is a largest series of 5 cases of lymphoepithelioma-like carcinoma (lec) of the breast attempting to look at the expression of basal cytokeratins (cks), human papillomavirus, and epstein-barr virus-encoded rnas in these tumors. five cases were selected after stringent evaluation of all breast carcinomas showing dense lymphoid infiltration. histologically, all these tumors showed the typical histology except 1 tumor that showed an unusual granulomatous response. all tumors were negative for ... | 2016 | 27806845 |
| epstein-barr virus: more than 50 years old and still providing surprises. | it is more than 50 years since the epstein-barr virus (ebv), the first human tumour virus, was discovered. ebv has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. progress in the molecular analysis of ebv has revealed fundamental mechanisms of more general relevance to the oncogenic process. this timeline article highlights key milestones in the 50-year history of ebv and discusses how this virus provides a paradigm for exploiting ... | 2016 | 27687982 |
| mild form of guillain-barré syndrome in a patient with primary epstein-barr virus infection. | 2016 | 26837010 | |
| epstein-barr virus: diseases linked to infection and transformation. | epstein-barr virus (ebv) was first discovered in 1964, and was the first known human tumor virus now shown to be associated with a vast number of human diseases. numerous studies have been conducted to understand infection, propagation, and transformation in various cell types linked to human diseases. however, a comprehensive lens through which virus infection, reactivation and transformation of infected host cells can be visualized is yet to be formally established and will need much further i ... | 2016 | 27826287 |
| the early diagnosis of testicular natural killer/t-cell lymphoma. | testicular natural killer/t-cell lymphoma is a rare aggressive extranodal lymphoma associated with epstein-barr virus infection. time to diagnose is crucial as the disease is rapidly progressive and fatal. early suspicion is documented by imaging studies and testicular biopsies which are key factors for diagnosing testicular natural killer/t-cell lymphoma. however, no reports have described the results of imaging studies. in this paper, contrast-enhanced ultrasonography (ceus), fluorine-18-fuoro ... | 2016 | 27824969 |
| plasmid-based generation of induced neural stem cells from adult human fibroblasts. | direct reprogramming from somatic to neural cell types has become an alternative to induced pluripotent stem cells. most protocols employ viral expression systems, posing the risk of random genomic integration. recent developments led to plasmid-based protocols, lowering this risk. however, these protocols either relied on continuous presence of a variety of small molecules or were only able to reprogram murine cells. we therefore established a reprogramming protocol based on vectors containing ... | 2016 | 27822179 |
| patterns of failure and survival in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy in saudi arabia. | we aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (imrt) combined with chemotherapy. | 2016 | 27822060 |
| tet2 functions as a resistance factor against dna methylation acquisition during epstein-barr virus infection. | extensive dna methylation is observed in gastric cancer with epstein-barr virus (ebv) infection, and ebv infection is the cause to induce this extensive hypermethylaton phenotype in gastric epithelial cells. however, some 5' regions of genes do not undergo de novo methylation, despite the induction of methylation in surrounding regions, suggesting the existence of a resistance factor against dna methylation acquisition. we conducted an rna-seq analysis of gastric epithelial cells with and withou ... | 2016 | 27829228 |
| letter to the editor: regarding "neurologic complications caused by epstein-barr virus in pediatric patients". | 2016 | 27827810 | |
| epstein-barr virus associated primary intracranial leiomyoma in a patient with human immunodeficiency virus. | a leiomyoma is a low-grade tumor originating from smooth-muscle cells. primary intracranial leiomyoma is extremely rare and usually reported in immunocompromised patients. we present a case of primary intracranial leiomyoma in a 44-year-old male with a chief complaint of headache. the pathological analysis and relevant literature has been discussed. | 2016 | 27841145 |
| ebv infection and multiple sclerosis: lessons from a marmoset model. | multiple sclerosis (ms) is thought to be initiated by the interaction of genetic and environmental factors, eliciting an autoimmune attack on the central nervous system. epstein-barr virus (ebv) is the strongest infectious risk factor, but an explanation for the paradox between high infection prevalence and low ms incidence remains elusive. we discuss new data using marmosets with experimental autoimmune encephalomyelitis (eae) - a valid primate model of ms. the findings may help to explain how ... | 2016 | 27836419 |
| prognostic correlations between abo blood group and pre-treatment plasma epstein-barr virus dna in patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy. | the objective of this study is to assess the prognostic value of abo blood group in nasopharyngeal carcinoma (npc) treated by intensity-modulated radiotherapy (imrt). | 2016 | 27835689 |
| snhg8 is identified as a key regulator of epstein-barr virus(ebv)-associated gastric cancer by an integrative analysis of lncrna and mrna expression. | the epstein-barr virus (ebv) is associated with a variety of cancers, including gastric cancer, which has one of the highest mortality rates of all human cancers. long non-coding rnas (lncrnas) have been suggested to have important causal roles in gastric cancer. however, the interaction between lncrnas and ebv has not yet been studied. to this end, we sequenced 11,311 lncrnas and 144,826 protein-coding transcripts from four types of tissue: one non-ebv-infected gastric carcinoma (ebvngc) and it ... | 2016 | 27835598 |
| molecular detection of epstein - barr virus in nasopharyngeal carcinoma among sudanese population. | nasopharyngeal carcinoma (npc) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. npc caused by an interaction between infection with ebv and environmental and genetic factors, encompasses a multistep oncogenic process. the frequency of epstein-barr virus ebv among nasopharyngeal carcinoma is well known worldwide, however, in the sudan there is barely a published dat ... | 2016 | 27833652 |
| a possible link between the epstein-barr virus infection and autoimmune thyroid disorders. | the epstein-barr virus (ebv), also known as human herpesvirus 4, is a member of the herpesviridae virus family. ebv infection can cause infectious mononucleosis (im) in the lytic phase of ebv's life cycle. past ebv infection is associated with lymphomas, and may also result in certain allergic and autoimmune diseases. although potential mechanisms of autoimmune diseases have not been clearly elucidated, both genetic and environmental factors, such as infectious agents, are considered to be respo ... | 2016 | 27833448 |
| prognostic factors of methotrexate-associated lymphoproliferative disorders associated with rheumatoid arthritis and plausible application of biological agents. | to determine prognostic factors of methotrexate-associated lymphoproliferative disorder (mtx-lpd) and evaluate the efficacy and safety of biological therapy in rheumatoid arthritis (ra) complicated with mtx-lpd. | 2016 | 27846761 |
| a complicated course of acute viral induced pharyngitis, icteric hepatitis, acalculous cholecystitis, and skin rash. | this case reveals the complexities and challenges in the diagnosis of acute epstein-barr virus (ebv) infection, indicating the potential relationship between ebv infection and severe icteric hepatitis, acalculous cholecystitis, and lymphocytic vasculitis. we suggest including ebv infectious mononucleosis in the list of differential diagnoses when any of these clinical syndromes (or a combination thereof) occurs without apparent cause, especially in the presence of lymphocytosis. to our knowledge ... | 2016 | 27847520 |
| epstein-barr virus super-enhancer ernas are essential for myc oncogene expression and lymphoblast proliferation. | epstein-barr virus (ebv) super-enhancers (eses) are essential for lymphoblastoid cell (lcl) growth and survival. reanalyses of lcl global run-on sequencing (gro-seq) data found abundant enhancer rnas (ernas) being transcribed at eses. inactivation of ese components, ebv nuclear antigen 2 (ebna2) and bromodomain-containing protein 4 (brd4), significantly decreased ernas at eses -428 and -525 kb upstream of the myc oncogene transcription start site (tss). shrna knockdown of the myc -428 and -525 e ... | 2016 | 27864512 |
| chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (clippers) with intracranial epstein-barr virus infection: a case report. | chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (clippers) is an inflammatory disorder in the central nervous system (cns) with distinct clinical, radiological, and pathological features. the pathophysiology of clippers still remains unclear and the reports are quite few. although the radiological lesions were reported to be located predominantly in the pons, brachium pontis, and cerebellum, other adjacent structures such as the white matter and spin ... | 2016 | 27861371 |
| mouse model for acute epstein-barr virus infection. | epstein-barr virus (ebv) infects human b cells and drives them into continuous proliferation. two key viral factors in this process are the latent membrane proteins lmp1 and lmp2a, which mimic constitutively activated cd40 receptor and b-cell receptor signaling, respectively. ebv-infected b cells elicit a powerful t-cell response that clears the infected b cells and leads to life-long immunity. insufficient immune surveillance of ebv-infected b cells causes life-threatening lymphoproliferative d ... | 2016 | 27856754 |
| the epstein-barr virus immunoevasins bcrf1 and bplf1 are expressed by a mechanism independent of the canonical late pre-initiation complex. | subversion of host immune surveillance is a crucial step in viral pathogenesis. epstein-barr virus (ebv) encodes two immune evasion gene products, bcrf1 (viral il-10) and bplf1 (deubiquitinase/deneddylase); both proteins suppress antiviral immune responses during primary infection. the bcrf1 and bplf1 genes are expressed during the late phase of the lytic cycle, an essential but poorly understood phase of viral gene expression. several late gene regulators recently identified in beta and gamma h ... | 2016 | 27855219 |
| epstein-barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis. | epstein-barr virus (ebv) has been associated with several types of human cancers. in the host, ebv can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as ebv reactivation. although ebv in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. this review focuses on the mechanisms by which ebv reactivatio ... | 2016 | 27877083 |
| epstein-barr virus-associated mucocutaneous ulcer in a patient with t-cell acute lymphoblastic leukemia: importance of accurate diagnosis and conservative management. | epstein-barr virus-associated mucocutaneous ulcer (ebv-mcu) is a recently characterized entity that falls under the spectrum of ebv-lymphoproliferative disorders. first described in 2010 by dojcinov et al, it is an ebv-driven localized proliferation of b cells, occurring in mucocutaneous tissues including the skin, the oropharynx, and the gastrointestinal tract of immunosuppressed patients in the absence of an intact t-cell repertoire. typically, it has been described in elderly patients with ag ... | 2016 | 27879545 |
| pulmonary lymphomatoid granulomatosis- a case report with review of literature. | lymphomatoid granulomatosis is a rare, epstein barr virus (ebv)-associated systemic angiodestructive disorder that may progress to a diffuse large b cell lymphoma. pulmonary involvement occurs in over 90 % cases followed by kidney, skin and brain. who classifies lymphomatoid granulomatosis under the generic heading of b cell proliferations of uncertain malignant potential. radiologically, pulmonary lymphomatoid granulomatosis (plg) presents with non specific findings making histopathology the go ... | 2016 | 27872542 |
| expanding diversity in molecular structures and functions of the il-6/il-12 heterodimeric cytokine family. | the interleukin (il)-6/il-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. this cytokine family has very unique characteristics in that they comprise two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. the members of this cytokine family are increasing; currently, there are more than six cytokines, including the tentatively named cytokines il-y (p28/p40), il-12 (p35/p40), il-23 (p19/p40), i ... | 2016 | 27867385 |
| viral carcinogenesis. | cancer has been recognized for thousands of years. egyptians believed that cancer occurred at the will of the gods. hippocrates believed human disease resulted from an imbalance of the four humors: blood, phlegm, yellow bile, and black bile with cancer being caused by excess black bile. the lymph theory of cancer replaced the humoral theory and the blastema theory replaced the lymph theory. rudolph virchow was the first to recognize that cancer cells like all cells came from other cells and beli ... | 2016 | 27865457 |
| ebv infection is prevalent in the adenoid and palatine tonsils in adults. | epstein-barr virus (ebv) is associated with the pathogenesis of several diseases in both adults and children. however, there have been no reports on the prevalence and amount of ebv in the adenoids of adults; thus, it is important to investigate these in the adenoids and tonsils of adults and children. in this study, 67 patients who underwent tonsillectomy or adenotonsillectomy were included and divided into two groups: adults aged ≥ 16 years (n = 35) and children aged <16 years (n = 32). patien ... | 2016 | 27864888 |
| novel mutation in dock8-hies with severe phenotype and successful transplantation. | hyper-ige syndrome (hies) due to dock8 deficiency is an autosomal recessive (ar) primary combined immunodeficiency which results in significant morbidity and mortality at a young age. different mutations in the dock8 gene can lead to variable severity of the disease. | 2016 | 27890707 |
| primary iris leiomyoma. | intraocular leiomyomas are uncommon and usually occur in the ciliary body. primary leiomyoma of the iris is both rare and a difficult diagnosis to make, given melanocytic tumors are more common and may be amelanotic. the somewhat controversial diagnosis of iris leiomyoma requires further confirmation by immunohistochemistry and electron microscopy. herein, we describe a 58-year-old man with a 2-mm round translucent pink lesion of the iris. the tumor was excised by sector iridectomy. immunohistoc ... | 2016 | 27890619 |
| angiogenic factors are associated with multiple sclerosis. | a growing body of evidence suggests that angiogenesis plays a crucial role in the pathogenesis of multiple sclerosis (ms). animal models of ms show a significant improvement when the process of angiogenesis is halted. in this study, we measured the serum levels of vascular-endothelial growth factor (vegf), soluble endoglin (seng), angiopoietin 1(ang-1), angiopoietin 2 (ang-2), and uric acid (ua) as well as serum anti-epstein-barr virus (ebv) ebna-1 igg in 50 ms patients (including 20 newly diagn ... | 2016 | 27887749 |
| epigenetic impact on ebv associated b-cell lymphomagenesis. | epigenetic modifications leading to either transcriptional repression or activation, play an indispensable role in the development of human cancers. epidemiological study revealed that approximately 20% of all human cancers are associated with tumor viruses. epstein-barr virus (ebv), the first human tumor virus, demonstrates frequent epigenetic alterations on both viral and host genomes in associated cancers-both of epithelial and lymphoid origin. the cell type-dependent different ebv latent gen ... | 2016 | 27886133 |
| epstein-barr virus associated hemophagocytic syndrome after scrub typhus infection. | there have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (hps), most of which were treated successfully using adequate antibiotics. here, we report a case of epstein-barr virus (ebv)-associated hps after scrub typhus infection that was not improved using antirickettsial treatment. a 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-da ... | 2016 | 27883370 |
| novel biomarkers of nasopharyngeal carcinoma metastasis risk identified by reverse phase protein array based tumor profiling with consideration of plasma epstein-barr virus dna load. | in patients with epstein-barr virus (ebv) associated nasopharyngeal carcinoma (npc), intertumor heterogeneity causes interpatient heterogeneity in the risk of distant metastasis. we aimed to identify novel biomarkers of metastasis risk using reverse phase protein array (rppa) profiling of npc patients at risk for metastasis and considering plasma ebv dna load. | 2016 | 27883284 |
| sjögren's syndrome complicated by myeloid/natural killer cell precursor acute leukemia: case report and review of the literature. | we report a case of sjögren's syndrome (ss) complicated by myeloid/natural killer (nk) cell precursor acute leukemia (m/nkpal). a 75-year-old woman with a previous ss history for 2 years was routinely treated. peripheral blood progenitor cells were increased, and subsequent bone marrow cell morphology examination showed the presence of acute myeloid leukemia type m4. however, flow cytometry analysis revealed that cd7/cd56/cd33/cd34/hla-dr/ccd3 were all positive and myeloperoxidase- (mpo-) specif ... | 2016 | 27882252 |
| epstein-barr virus in nasopharyngeal carcinoma of guatemalan and brazilian patients. | nasopharyngeal carcinoma (npc) is highly associated with epstein-barr virus (ebv), particularly the undifferentiated nonkeratinizing subtype. prevalence of ebv in npc in countries such as guatemala and brazil has not been studied. | 2016 | 27881609 |
| id1 upregulation and foxo3a downregulation by epstein-barr virus-encoded lmp1 in hodgkin's lymphoma. | cancer-initiating cells (cics) are specialized cells that have the ability to self-renew and are multipotent. we recently demonstrated that forkhead box o3a (foxo3a)-expressing cells exhibited a cic-like potential in hodgkin's lymphoma (hl). a proportion of hl patients are infected with epstein-barr virus (ebv). ebv-encoded latent membrane protein (lmp) 1 downregulates foxo3a, suggesting that foxo3a expression may be abolished in ebv-positive hl. inhibitors of dna-binding (id) proteins are highl ... | 2016 | 27900085 |
| shared drink and a soft punch: an almost deadly combination. | injuries of the spleen in blunt abdominal trauma are common and can lead to fatal bleeding. the diagnostic of choice to determine severity and treatment is usually made in contrast-enhanced ct. in our case we used contrast-enhanced ultrasound to identify the origin of an intra-abdominal bleeding following a minor trauma in a patient with splenomegaly due to an epstein-barr virus infection. | 2016 | 27899385 |
| core binding factor (cbf) is required for epstein-barr virus ebna3 proteins to regulate target gene expression. | chip-seq performed on lymphoblastoid cell lines (lcls), expressing epitope-tagged ebna3a, ebna3b or ebna3c from ebv-recombinants, revealed important principles of ebna3 binding to chromatin. when combined with global chromatin looping data, ebna3-bound loci were found to have a singular character, each directly associating with either ebna3-repressed or ebna3-activated genes, but not with both. ebna3a and ebna3c showed significant association with repressed and activated genes. significant direc ... | 2016 | 27903901 |
| a case of cutaneous epstein-barr virus-associated diffuse large b-cell lymphoma in an angioimmunoblastic t-cell lymphoma. | 2016 | 27904290 | |
| possible mechanisms of acquisition of herpesvirus virokines. | the genomes of certain types of human and primate herpesviruses contain functional homologs of important host cytokines (il-6, il-17, and il-10), or so-called virokines. virokines can interact with immune cell receptors, transmit a signal to them, and thus switch the type of immune response that facilitates viral infection development. in this work, we have summarized possible ways of virokine origin and proposed an evolutionary scenario of virokine acquisition with involvement of retroviral coi ... | 2016 | 27914460 |
| synchronous microscopic epstein-barr virus-positive diffuse large b-cell lymphoma of the adrenal and lymphoplasmacytic lymphoma. | lymphomas arising in the adrenal are rare, and to our knowledge, 2 cases of epstein-barr virus (ebv)-positive diffuse large b-cell lymphomas (dlbcl) in an adrenal pseudocyst have been reported. we report an incidental ebv-positive dlbcl arising in an adrenal pseudocyst in a 58-year-old man with a 7-year history of lymphoplasmacytic lymphoma (lpl). the dlbcl was present in the fibrinous exudate, while the lpl resided in the cyst wall. the patient underwent de-roofing of the same cyst 3 years prev ... | 2016 | 27913781 |
| checkpoint inhibition and cellular immunotherapy in lymphoma. | hodgkin and non-hodgkin lymphoma are both good targets for immunotherapy, as they are accessible to antibodies and cell-based immunotherapy, express costimulatory molecules, and express lineage-restricted, viral, and unique tumor antigens. blockade of the programmed-death 1 (pd-1) immune checkpoint has produced very encouraging response rates in patients with hodgkin lymphoma, whereas adoptive transfer of epstein-barr virus (ebv)-specific t cells has shown clinical activity in patients with post ... | 2016 | 27913506 |
| agranulocytosis occurrence following recent acute infectious mononucleosis. | infectious mononucleosis secondary to epstein-barr virus typically follows a relatively benign and self-limited course. a small subset of individuals may develop further progression of disease including hematologic, neurologic, and cardiac abnormalities. a mild transient neutropenia occurring during the first weeks of acute infection is a common finding however in rare cases a more profound neutropenia and agranulocytosis may occur up to 6weeks following the onset of initial symptoms. we describ ... | 2016 | 27912922 |
| a 48-year-old man with leukopenia, jaundice, and skin rash after lung transplantation. | a 48-year-old african-american male subject presented with progressive fatigue, jaundice, and new-onset leukopenia 12 weeks after undergoing bilateral lung transplantation for advanced pulmonary sarcoidosis. his transplant surgery and immediate posttransplantation course were uneventful. induction immunosuppression included methylprednisolone 500 mg intraoperatively and basiliximab (anti-il-2 monoclonal antibody) on days 0 and 4 after transplantation. his maintenance immunosuppression posttransp ... | 2016 | 27938774 |
| the cytoplasmic tail domain of epstein-barr virus gh regulates membrane fusion activity through altering gh binding to gp42 and epithelial cell attachment. | epstein-barr virus (ebv) is associated with infectious mononucleosis and a variety of cancers as well as lymphoproliferative disorders in immunocompromised patients. ebv mediates viral entry into epithelial and b cells using fusion machinery composed of four glycoproteins: gb, the gh/gl complex, and gp42. gb and gh/gl are required for both epithelial and b cell fusion. the specific role of gh/gl in fusion has been the most elusive among the required herpesvirus entry glycoproteins. previous muta ... | 2016 | 27935841 |
| epstein-barr virus nuclear antigen 1 (ebna1) interacts with regulator of chromosome condensation (rcc1) dynamically throughout the cell cycle. | the epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is a sequence-specific dna binding protein which plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of dna replication onto the origin (orip) and by tethering the viral dna onto the mitotic chromosomes. whereas the mechanisms of viral dna replication are well documented, those involved in tethering ebna1 to the cellular chromatin are far from being understood. here, we have identified reg ... | 2016 | 27959790 |
| erratum to: molecular detection of epstein - barr virus in nasopharyngeal carcinoma among sudanese population. | [this corrects the article doi: 10.1186/s13027-016-0104-7.]. | 2016 | 27956937 |
| total synthesis and in vitro anti-tumor-promoting activities of racemic acetophenone monomers from acronychia trifoliolata. | six acetophenone derivatives, acronyculatins i (1), j (2), k (3), l (4), n (5), and o (6), were recently isolated from acronychia trifoliolata, and the structure of the known acronyculatin b (7) was revised. because of the limited quantities of isolated products as well as their structure similarity, racemic acronyculatins i-l, n, o, and b (1-7) were synthesized to confirm their structures and to obtain sufficient material for biological evaluation. trihydroxyacetophenone was converted to the ta ... | 2016 | 27933896 |
| antiviral agents for infectious mononucleosis (glandular fever). | infectious mononucleosis (im) is a clinical syndrome, usually caused by the epstein barr virus (epv), characterised by lymphadenopathy, fever and sore throat. most cases of symptomatic im occur in older teenagers or young adults. usually im is a benign self-limiting illness and requires only symptomatic treatment. however, occasionally the disease course can be complicated or prolonged and lead to decreased productivity in terms of school or work. antiviral medications have been used to treat im ... | 2016 | 27933614 |
| intrapancreatic splenule in a pancreas allograft: case report. | a 16-year-old white man was involved in a motor vehicle collision and suffered head, chest, and abdominal trauma. despite initial resuscitative efforts, he progressed to brain death and was designated to be an organ donor by his family. he had no earlier medical or surgical history and no high-risk behaviors. blood work revealed normal creatinine, liver function tests, lipase, and amylase. viral serologies were negative except for cytomegalovirus igg and epstein-barr virus nucleic acid. imaging ... | 2016 | 27932184 |
| rapidly fatal hemophagocytic lymphohistiocytosis developing within six days following deceased-donor renal transplantation: case report. | hemophagocytic lymphohistiocytosis (hlh) is an often fatal hyperinflammatory syndrome that may complicate malignancy, infection, rheumatic disease, or immunosuppression. hlh after kidney transplantation is most often triggered by infection, usually herpes viruses such as cytomegalovirus and epstein-barr virus (ebv). it usually occurs early after transplantation. we present a case of hlh triggered by reactivation of ebv that pursued a rapidly fatal course within 6 days of receiving a deceased-don ... | 2016 | 27932162 |
| primary immunodeficiencies associated with ebv-induced lymphoproliferative disorders. | primary immunodeficiency diseases (pids) are a subgroup of inherited immunological disorders that increase susceptibility to viral infections. among the range of viral pathogens involved, ebv remains a major threat because of its high prevalence of infection among the adult population and its tendency to progress to life-threatening lymphoproliferative disorders (lpds) and/or malignancy. the high mortality in immunodeficient patients with ebv-driven lpds, despite institution of diverse and often ... | 2016 | 27931829 |
| structural basis for epstein-barr virus host cell tropism mediated by gp42 and ghgl entry glycoproteins. | herpesvirus entry into host cells is mediated by multiple virally encoded receptor binding and membrane fusion glycoproteins. despite their importance in host cell tropism and associated disease pathology, the underlying and essential interactions between these viral glycoproteins remain poorly understood. for epstein-barr virus (ebv), ghgl/gp42 complexes bind hla class ii to activate membrane fusion with b cells, but gp42 inhibits fusion and entry into epithelial cells. to clarify the mechanism ... | 2016 | 27929061 |
| positive regulation of taz expression by ebv-lmp1 contributes to cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma. | the epstein-barr virus latent membrane protein 1 (lmp1) is an integral membrane protein. lmp1 has been reported to activate the nf-κb and mitogen-activated protein kinase pathways. however, these effects alone are unable to account for the profound oncogenic properties of lmp1. taz is one of the nuclear effectors of hippo-related pathways and highly expressed in many human tumors. here, we reported that taz was frequently expressed in lmp1-positive nasopharyngeal carcinoma. in npc cell lines, we ... | 2016 | 27926490 |
| novel epstein-barr virus-like particles incorporating gh/gl-ebna1 or gb-lmp2 induce high neutralizing antibody titers and ebv-specific t-cell responses in immunized mice. | previous epstein-barr virus (ebv) prophylactic vaccines based on the major surface glycoprotein gp350/220 as an immunogen have failed to block viral infection in humans, suggesting a need to target other viral envelope glycoproteins. in this study, we reasoned that incorporating gh/gl or gb, critical glycoproteins for viral fusion and entry, on the surface of a virus-like particle (vlp) would be more immunogenic than gp350/220 for generating effective neutralizing antibodies to prevent viral inf ... | 2016 | 27926486 |
| increased immunoglobulin g4-positive plasma cells in lymphadenoma of the salivary gland: an immunohistochemical comparison among lymphoepithelial lesions. | lymphadenoma (la) of the salivary gland, nonsebaceous type, is an uncommon benign lymphoepithelial neoplasm. the histogenesis of the lymphoid component of la is under debate as in warthin's tumor. a recent study has described immunoglobulin (ig) class switching to igg4 in a subset of warthin's tumors. the aim of this study is to evaluate igg4 status of la and presume the role of igg4 status in pathogenesis of la. | 2016 | 27941558 |
| combining an antiviral with rituximab in ebv-related haemophagocytic lymphohistiocytosis led to rapid viral clearance; and a comprehensive review. | epstein-barr virus (ebv)-related haemophagocytic lymphohistiocytosis (ebvr-hlh) has a better prognosis when the virus is rapidly cleared, but the best antiviral approach is controversial. we present a patient to whom the therapeutic standard rituximab was co-administered with valacyclovir and an hlh-specific treatment with favourable viral and clinical responses. we conducted an extensive literature review and contacted several world reference centres and experts to inquire about their approache ... | 2016 | 27941111 |
| plasmodium chabaudi infection induces aid expression in transitional and marginal zone b cells. | endemic burkitt's lymphoma (ebl) is associated with epstein-barr virus and repeated malaria infections. a defining feature of ebl is the translocation of the c-myc oncogene to the control of the immunoglobulin promoter. activation-induced cytidine deaminase (aid) has been shown to be critical for this translocation. malaria infection induces aid in germinal center b cells, but whether malaria infection more broadly affects aid activation in extrafollicular b cells is unknown. | 2016 | 27980783 |
| cord blood transplantation following reduced-intensity conditioning for epstein-barr virus-associated hemophagocytic lymphohistiocytosis during systemic lupus erythematosus treatment. | epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) is a serious disorder in which monoclonal growth of t cells infected with ebv and macrophage activation cause pancytopenia, high fever and acute liver failure. patients with chemotherapy- or immunosuppression-resistant ebv-hlh require allogeneic hematopoietic stem cell transplantation (allo-hsct), but patients who have no sibling donors may not have time to wait for an unrelated donor. in pediatric patients, there are som ... | 2016 | 27980302 |
| graves' orbitopathy, idiopathic orbital inflammatory pseudotumor and epstein-barr virus infection: a serological and molecular study. | one of the hypotheses on the pathogenesis of autoimmune diseases, including graves' disease (gd) and graves' orbitopathy (go), involves bacterial or viral infections. recently, epstein-barr virus (ebv) has been proposed to play a role in the pathogenesis of idiopathic orbital inflammatory pseudotumor (ioip) in asians. the aim of the present study was to investigate the possible association of go with ebv infection/exposure, as compared with ioip, using serum and tissue samples, as well as primar ... | 2016 | 27987077 |
| retinal vasculitis associated with epstein-barr virus infection, a case report. | to report a case of retinal vasculitis associated with epstein-barr virus infection. | 2016 | 28030457 |
| c-reactive protein/albumin ratio (car) as a prognostic factor in patients with non-metastatic nasopharyngeal carcinoma. | background: the c-reactive protein/albumin (crp/alb) ratio has recently been associated with clinical outcomes in patients suffering various types of cancer. in this retrospective study, we investigated the prognostic value of the pre-treatment crp/alb ratio (car) in non-metastatic nasopharyngeal carcinoma (npc) patients. methods: the cohort included 2685 patients with non-metastatic npc. univariate and multivariate cox proportional hazards analyses were applied to evaluate the associations of c ... | 2016 | 27994675 |
| comparison of circulating tumour cells and circulating cell-free epstein-barr virus dna in patients with nasopharyngeal carcinoma undergoing radiotherapy. | quantification of epstein-barr virus (ebv) cell-free dna (cfdna) is commonly used in clinical settings as a circulating biomarker in nasopharyngeal carcinoma (npc), but there has been no comparison with circulating tumour cells (ctcs). our study aims to compare the performance of ctc enumeration against ebv cfdna quantitation through digital pcr (dpcr) and quantitative pcr. 74 plasma samples from 46 npc patients at baseline and one month after radiotherapy with or without concurrent chemotherapy ... | 2016 | 27994225 |
| activation of sp1-mediated transcription by rta of epstein-barr virus via an interaction with mcaf1. | 2016 | 28007940 | |
| pathological mandibular fracture associated with diffuse large b-cell lymphoma in hiv-positive patient. | this article describes the occurrence of diffuse large b-cell lymphoma in a 39-year-old human immunodeficiency virus-positive patient. the patient sought medical care complaining of increased volume in the right mandibular angle and imaging tests showed an extensive radiolucency with undefined boundaries compromising the mandibular border. after the incisional biopsy, the patient had a pathological fracture in the region, which was properly treated in a second surgical procedure using a 2.4-mm r ... | 2016 | 28005758 |
| biopsy-proven case of epstein-barr virus (ebv)-associated vasculitis of the central nervous system. | a 75-year-old woman was admitted to our hospital with rapidly deteriorating consciousness disturbance. she had a 7-year history of rheumatoid arthritis (ra), which had been treated with methotrexate (mtx) and prednisolone. brain t2-weighted mri showed diffuse high-intensity lesions in the cerebral subcortical and deep white matter, bilateral basal ganglia and thalamus. a cerebrospinal fluid examination revealed elevated protein levels and positive epstein-barr virus (ebv) dna. human immunodefici ... | 2016 | 28004435 |
| a neutralized human lmp1-igg inhibits enktl growth by suppressing the jak3/stat3 signaling pathway. | latent membrane protein 1 (lmp1), which is associated with the development of different types of epstein-barr virus (ebv) related lymphoma, has been suggested to be an important oncoprotein. in this study, a human anti-lmp1 igg antibody (lmp1-igg) was constructed and characterized by elisa, western blotting (wb), affinity and immunohistochemistry (ihc) analyses. cck-8, mtt, apoptosis assays, antibody-dependent cell-mediated cytotoxicity (adcc) and cdc (complement-dependent cytotoxicity) assays w ... | 2016 | 28009988 |
| regulatory t cells in endemic burkitt lymphoma patients are associated with poor outcomes: a prospective, longitudinal study. | deficiencies in epstein-barr virus (ebv)-specific t cell immunosurveillance appear to precede the development of endemic burkitt lymphoma (ebl), a malaria-associated pediatric cancer common in sub-saharan africa. however, t cell contributions to ebl disease progression and survival have not been characterized. our objective was to investigate regulatory and inflammatory t cell responses in ebl patients associated with clinical outcomes. by multi-parameter flow cytometry, we examined peripheral b ... | 2016 | 28033393 |
| cdc grand rounds: chronic fatigue syndrome - advancing research and clinical education. | chronic fatigue syndrome (cfs) is a complex and serious illness that is often misunderstood. experts have noted that the terminology "chronic fatigue syndrome" can trivialize this illness and stigmatize persons who experience its symptoms (1). the name was coined by a group of clinicians convened by cdc in the late 1980s to develop a research case definition for the illness, which, at the time, was called chronic epstein-barr virus syndrome. the name cfs was suggested because of the characterist ... | 2016 | 28033311 |
| short-term inhibition of tert induces telomere length-independent cell cycle arrest and apoptotic response in ebv-immortalized and transformed b cells. | besides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (tert) may promote tumorigenesis through extra-telomeric functions. the possible therapeutic effects of bibr1532 (bibr), a powerful tert inhibitor, have been evaluated in different cellular backgrounds, but no data are currently available regarding epstein-barr virus (ebv)-driven b-cell malignancies. our aim was to characterize the biological effects of tert inhibition by bibr on ebv-immortalized lymphoblastoid ... | 2016 | 28032863 |
| pulmonary lymphoepithelioma-like carcinoma with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (eml4-alk) fusion gene. | a pulmonary lymphoepithelioma-like carcinoma (plelc) is similar to a lymphoepithelioma, a subtype of nasopharyngeal carcinoma and commonly associated with epstein-barr virus infection which is a rare tumour and classified in the group of "other and unclassified carcinoma" in the latest 2015 world health organization (who) classification. some reports of lymphoepithelioma-like carcinoma (lelc) have noted an epidermal growth factor receptor (egfr) mutation, whereas none have noted a mutation of th ... | 2016 | 28031835 |
| significance of interviral recombination as novel mechanism for extending viral disease repertoire. | the recent observation of interviral recombination between members of two distinct classes of dna viruses has opened the gates to a new field of human disease development. in all cases studied thus far interviral recombination is a rare event that requires special circumstances for intracellular interaction of participating viral genomes. the rarity and special requirements do not detract from the potential clinical significance of resulting recombinants, as exemplified by recombination between ... | 2016 | 28018769 |
| a rare case of hemophagocytic lymphohistiocytosis associated with parvovirus b19 infection. | hemophagocytic lymphohistiocytosis (hlh) is a rare but life-threatening syndrome resulting from excessive immune activation. secondarily, hlh is often associated with autoimmune disease, infection, and malignancy. the most common infectious trigger is epstein-barr virus (ebv) infection. hlh is rarely triggered by parvovirus b19. we discuss a case of a 62-year-old male who presented with multi-organ failure with presumed septic shock who eventually was diagnosed with hlh, with positive parvovirus ... | 2016 | 28018767 |
| combination immunosuppressive therapy including rituximab for epstein-barr virus-associated hemophagocytic lymphohistiocytosis in adult-onset still's disease. | hemophagocytic lymphopcytosis (hlh) is a life-threatening condition. it can occur either as primary form with genetic defects or secondary to other conditions, such as hematological or autoimmune diseases. certain triggering factors can predispose individuals to the development of hlh. we report the case of a 25-year-old male patient who was diagnosed with hlh in the context of adult-onset still's disease (aosd) during a primary infection with epstein-barr virus (ebv). during therapy with anakin ... | 2016 | 28018698 |
| from benign to malign in a case of cervical adenopathy in a 17-year-old adolescent: diagnostic traps. | distinguishing between benign and malign adenopathies remains a challenge and could represent a source of error in a diagnosis. we report a case of right laterocervical adenopathy in a 17-year-old teenager admitted to hospital with an episode of fever associated with dysphagia, congested pharynx, and pultaceous deposits. initially the adenopathy was considered to be secondary to a coinfection with streptococcus b-hemolytic and epstein-barr virus, as suggested by the positive bacteriological and ... | 2016 | 28018695 |
| acute gastritis associated with epstein-barr virus infection in a child. | infectious mononucleosis is epstein-barr virus (ebv) inducing a self-limiting clinical syndrome characterized by fever, sore throat, hepatosplenomegaly, and generalized lymphadenopathy. gastrointestinal symptoms of ebv infection are nonspecific and occur rarely. ebv inducing acute gastrointestinal pathology is poorly recognized without suspicion. careful consideration is needed to diagnose gastric involvement of ebv infection including gastric lymphoma, gastric cancer, and gastritis. a few recen ... | 2016 | 28018450 |
| nkg2a-expressing natural killer cells dominate the response to autologous lymphoblastoid cells infected with epstein-barr virus. | epstein-barr virus (ebv) is a human γ-herpesvirus that establishes latency and lifelong infection in host b cells while achieving a balance with the host immune response. when the immune system is perturbed through immunosuppression or immunodeficiency, however, these latently infected b cells can give rise to aggressive b cell lymphomas. natural killer (nk) cells are regarded as critical in the early immune response to viral infection, but their role in controlling expansion of infected b cells ... | 2016 | 28018364 |
| herpesviruses dutpases: a new family of pathogen-associated molecular pattern (pamp) proteins with implications for human disease. | the human herpesviruses are ubiquitous viruses and have a prevalence of over 90% in the adult population. following a primary infection they establish latency and can be reactivated over a person's lifetime. while it is well accepted that human herpesviruses are implicated in numerous diseases ranging from dermatological and autoimmune disease to cancer, the role of lytic proteins in the pathophysiology of herpesvirus-associated diseases remains largely understudies. only recently have we begun ... | 2016 | 28036046 |
| [the understanding of epstein-barr virus associated lymphoproliferative disorder]. | in recent years, there are increasing articles concerning epstein-barr virus associated lymphoproliferative disorder (ebv+ lpd), and the name of ebv+ lpd is used widely. however, the meaning of ebv+ lpd used is not the same, which triggered confusion of the understanding and obstacles of the communication. in order to solve this problem. literature was reviewed with combination of our cases to clarify the concept of ebv+ lpd and to expound our understanding about it. in general, it is currently ... | 2016 | 28056294 |
| epstein-barr virus dna monitoring in serum and whole blood in pediatric liver transplant recipients who do or do not discontinue immunosuppressive therapy. | the rate of ptld can be reduced by weaned is guided by monitoring of ebv dna. in this single-center retrospective case series study, we analyzed how reduction in is influenced ebv dna levels in whole blood and serum in 30 children during the first year after liver transplantation, and how these levels were related to symptoms putatively due to ebv. primary and reactivated ebv infection was seen in 18 (60%) and eight patients (27%), respectively. thirteen patients (42%) developed chronic high loa ... | 2016 | 28039929 |
| persistent epstein-barr viral load in epstein-barr viral naïve pediatric heart transplant recipients: risk of late-onset post-transplant lymphoproliferative disease. | to examine the risk of late-onset post-transplant lymphoproliferative disorder (ptld) in the presence of persisting high epstein-barr virus (ebv) in ebv naïve pediatric heart transplant (ht) recipients. | 2016 | 28058224 |
| [tnfaip3 deletion status in classical hodgkin lymphoma and its relation to epstein-barr virus]. | objective: to investigate the tnfaip3/a20 abnormalities and its association with epstein-barr virus (ebv) in classical hodgkin lymphoma (chl). methods: formalin-fixed, paraffinembedded tissue blocks of 54 chl patients were collected and subjected to the construction of tissue microarray (tma) for further analyses. ebv status was evaluated by in situ hybridization (ish) for eber1/2 and immunohistochemistry (ihc) with anti-lmp-1 antibody. fluorescence in situ hybridization (fish) and ihc were perf ... | 2016 | 28088970 |
| pre-treatment serum inflammatory cytokines as survival predictors of patients with nasopharyngeal carcinoma receiving chemoradiotherapy. | the present study aimed to examine the predictability of pre-treatment serum levels of interleukin (il)-1β, il-6 and tumor necrosis factor (tnf)-α for determining the outcome of patients with nasopharyngeal carcinoma (npc) assigned for chemoradiotherapy. a total of 35 patients with npc were subjected to clinical examination and evaluation of performance status using karnofsky scoring. nasopharyngoscopy was performed for evaluation and to obtain a biopsy. blood samples were obtained pre- and post ... | 2016 | 28105362 |
| trim5α promotes ubiquitination of rta from epstein-barr virus to attenuate lytic progression. | replication and transcription activator (rta), a key protein expressed by epstein-barr virus (ebv) during the immediate-early stage of the lytic cycle, is responsible for the activation of viral lytic genes. in this study, gst-pulldown and coimmunoprecipitation assays showed that rta interacts in vitro and in vivo with trim5α, a host factor known to be involved in the restriction of retroviral infections. confocal microscopy results revealed that rta colocalizes with trim5α in the nucleus during ... | 2016 | 28105027 |
| metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature. | in recent years, significant advances have been made in cancer immunotherapy. here, we present the first report of a patient with lymphoepithelioma-like carcinoma (lelc) of the lung, an epstein-barr virus (ebv)-associated lung cancer, who was treated with nivolumab, a fully human igg4 anti-pd-1 monoclonal antibody. we also carry out a focused review to identify and examine studies of lelc of the lung in the literature. this case report highlights the need to further assess the role of immune che ... | 2016 | 28149767 |
| asymptomatic epstein-barr virus shedding in the urine of kidney transplant recipients: case reports and review of the literature. | epstein-barr virus (ebv) is associated with a wide range of malignancies and complications like post-transplant lymphoproliferative disorder (ptld). to suppress active ebv infection in transplant recipients, who are at a heightened risk of developing ptld, ebv dnaemia monitoring has been recommended. quantitative multiplex real time polymerase chain reaction (qmrtpcr) offered the advantage of detection of more than one target in the same sample. we present four cases of kidney transplant recipie ... | 2016 | 28191298 |
| leishmania infantum and epstein-barr virus co-infection in a patient with hemophagocytosis. | the authors describe a rare case of a 27- year old previously healthy male presenting with high grade fever, pancytopenia, hepatosplenomegaly, high levels of ferritin and triglyceride, suggesting a diagnosis of hemophagocytic lymphohistiocytosis (hlh) syndrome. other investigations showed a positive leishmania infantum serology and high epstein-barr virus (ebv) viremia. the diagnosis of a visceral leishmaniasis was confirmed by bone morrow biopsy, which showed leishman-donovan bodies and evidenc ... | 2016 | 28191297 |
| treatment of post-transplantation lymphoproliferative disorders after kidney transplant with rituximab and conversion to m-tor inhibitor. | post-transplantation lymphoproliferative disorders are serious complications of organ transplantation which treatment is not yet standardized. | 2016 | 28293043 |
| [promotion of porphyromonas gingivalis to viral disease]. | chronic periodontitis is one of the most common oral diseases in humans, the main recognized pathogenic bac-terium of which is the porphyromonas gingivalis. various types of viruses have been detected in periodontal disease in situ, and the joint action of viral and bacterial pathogens infection mechanism are complicated. porphyromonas gingivalis has the characteristics resulting from the interaction with a variety of bacterium viruses, which may be the reason for chronic perio-dontitis being a ... | 2016 | 28317365 |
| epstein barr virus hemophagocytic lymphohistiocytosis related to rituximab use and immunopathogenetic insights. | anti-cd20-based chemo-immunotherapeutic regimens have been suggested to assist in the management of epstein-barr virus (ebv)-induced hemophagocytic lymphohistiocytosis (hlh) and ebv-associated post-transplant lymphoproliferative disorders (ebv-ptld), by reducing ebv viral load and ebv-induced inflammation. herein we report a fatal ebv-related hlh in the context of hodgkin lymphoma (hl)-like richter's transformation of b chronic lymphocytic leukemia (b-cll), two months after rituximab treatment. ... | 2016 | 28340951 |
| gestational pityriasis rosea: suggestions for approaching affected pregnant women. | dear editor, pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (hhv)-6 and/or hhv-7 (1). it predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. several patients develop systemic s ... | 2016 | 28128088 |
| comprehensive polymerase chain reaction assay for detection of pathogenic dna in lymphoproliferative disorders of the ocular adnexa. | infectious agents have been identified as a major cause of specific types of human cancers worldwide. several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. this study aimed to conduct an exhaustive search for pathogenic dna in lymphoproliferative disorders (lpd) of the ocular adnexa in a total of 70 patients who were diagnosed with lpd of the ocular ... | 2016 | 27830722 |
| detection of epstein-barr virus in leucoreduced blood products. | this study examined the prevalence of three human herpesviruses (hhv), namely hhv-4 (epstein-barr virus/ebv), hhv-6b and hhv-7 in leucoreduced blood products obtained from the sainte-justine hospital blood bank. a total of 100 specimens, including 34 red blood cell concentrates, 33 platelet bags and 33 plasma units, were collected and screened by a sensitive pcr assay using virus-specific primers. positive units were then retested by quantitative pcr. of the 100 specimens, one platelet unit test ... | 2016 | 26383177 |
| analysis of the variability of epstein-barr virus genes in infectious mononucleosis: investigation of the potential correlation with biochemical parameters of hepatic involvement. | primary epstein-barr virus (ebv) infection is usually asymptomatic, although at times it results in the benign lymphoproliferative disease, infectious mononucleosis (im), during which almost half of patients develop hepatitis. the aims of the present study are to evaluate polymorphisms of ebv genes circulating in im isolates from this geographic region and to investigate the correlation of viral sequence patterns with the available im biochemical parameters. | 2016 | 28356886 |
| prevalence of several herpesviruses and human papillomavirus in acute apical abscesses. | to investigate and compare the radiographic size of acute apical abscess lesions for the presence of epstein-barr virus (ebv), human cytomegalovirus (hcmv), human herpesvirus-6 (hhv-6) and human papillomaviruses (hpv) dna by means of the real-time polymerase chain reaction (pcr) method. | 2016 | 26073223 |
| viruses in pulp and periapical inflammation: a review. | the presence of viruses in endodontic disease has been studied in the last decade. their presence is associated with periapical radiolucency and with clinical findings, such as pain. the aim of this review is to analyze the scientific evidence currently published about viruses in pulp and periapical inflammation, and its possible clinical implications. a literature review was carried out using the medline/pubmed database. the search was performed, in english and spanish, using the following keyw ... | 2016 | 25796386 |
| human cytomegalovirus-1 and epstein-barr virus-1 viral colonization of titanium and zirconia abutments: a split-mouth study. | human cytomegalovirus-1 (hcmv-1) and epstein-barr virus-1 (ebv-1) detection in submarginal plaque is linked to diseased states of the periodontium. in the present study, we evaluated the viral colonization of titanium and zirconia abutments by hcmv-1 and ebv-1 in a split-mouth study. | 2016 | 26283012 |
| epstein-barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. | chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. apart from bacteria, two herpesviruses, epstein-barr virus (ebv) and human cytomegalovirus (hcmv) are recognized as putative pathogens in apical periodontitis. although previous reports suggest the involvement of ebv in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. we hypothesize that ebv i ... | 2016 | 27515196 |