Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| acquired immunodeficiency syndrome, pneumocystis carinii pneumonia, and the danger of prognostication: apples to apples. | 1999 | 10397194 | |
| pneumocystis carinii pneumonia requiring intensive care management: survival and prognostic study in 110 patients with human immunodeficiency virus. | to perform a descriptive study of patients with acute respiratory failure secondary to acquired immunodeficiency syndrome-related pneumocystis carinii pneumonia and to identify variables that are predictive of death within 3 months. | 1999 | 10397214 |
| joint effects of hiv-1 rna levels and cd4 lymphocyte cells on the risk of specific opportunistic infections. | to evaluate the predictive value of baseline plasma hiv-1 rna levels and cd4 lymphocyte counts and early changes in these markers after initiating antiretroviral therapy on the risk of development of specific opportunistic infections (ois). | 1999 | 10397533 |
| enteric infections and diarrhea in human immunodeficiency virus-infected persons: prospective community-based cohort study. swiss hiv cohort study. | persons infected with human immunodeficiency virus (hiv) are at increased risk for diarrhea and enteric infections. we studied (1) the epidemiology of enteric pathogens associated with diarrhea, (2) the diagnostic yield of stool examination and endoscopic evaluation, (3) risks to develop diarrhea, and (4) the impact of diarrhea on patients' survival. | 1999 | 10399899 |
| usefulness of rat-derived antigen in the serodiagnosis of pneumocystis carinii infection. | sera from patients with likely and possible pneumocystis carinii pneumonia (pcp) on the basis of clinical information and laboratory investigations were tested by immunoblotting to assess the usefulness of trophozoites in the serodiagnosis of pcp. igg antibodies to 50-60- kda proteins were demonstrated with cyst antigen, but antibodies to additional proteins of 61, 70, 82, 95, 99 and 116 kda were found with trophozoite antigen. these bands were not demonstrated with control sera. igg antibody to ... | 1999 | 10403419 |
| rat model for dual opportunistic pathogen prophylaxis: cryptosporidium parvum and pneumocystis carinii. | 1999 | 10403453 | |
| trimethoprim-sulfamethoxazole. | after 25 years of use in the united states, trimethoprim-sulfamethoxazole (tmp-smx) is widely prescribed for various indications. by virtue of sequential blockade of microbial folic acid synthesis, the antimicrobial combination has excellent in vitro inhibitory activity against many common respiratory and urinary tract pathogens, as well as many nosocomial infecting strains. in patients infected with the human immunodeficiency virus, tmp-smx provides prophylactic and therapeutic potency against ... | 1999 | 10405706 |
| pneumocystis carinii polyamine catabolism. | dl-alpha-difluoromethylornithine (dfmo) causes polyamines of the aids-associated opportunistic pathogen pneumocystis carinii to diminish 15 times more rapidly than mammalian host cells. the proposed mechanism was that, unlike mammalian cells, p. carinii is unable to regulate polyamine catabolism when synthesis is blocked. to test this, the responses of the polyamine catabolic enzymes spermidine/spermine acetyltransferase (ssat) and polyamine oxidase (pao) were determined using a new high-perform ... | 1999 | 10409651 |
| [pneumocystis carinii pneumonia in aids. new concepts for an old problem]. | pneumocystis carinii (pc) is an ubiquitous pathogen phylogenetically considered a fungus. in individuals with t-cell deficiency, pc produces typically an interstitial pneumonia. the primary infection is, perhaps, transmitted airborne, and is acquired during early infancy. pc was a rare cause of disease until the advent of aids. in susceptible patients infected with hiv it remains a major cause of morbidity and mortality despite appropriate prophylaxis and treatment. mutations in the gene that en ... | 1999 | 10413901 |
| characterization of a multicopy family of genes encoding a surface-expressed serine endoprotease in rat pneumocystis carinii. | a unique family of genes encoding serine endoproteases related to the saccharomyces cerevisiae serine endoprotease kexin was identified in pneumocystis carinii. unlike previously described serine endoprotease genes that are single copies, multiple copies of the p. carinii serine endoprotease are distributed throughout the genome. the proteins predicted by these variant genes demonstrate sequence variability, but they retain the conserved active sites associated with endoprotease activity. the se ... | 1999 | 10417743 |
| [aids with inaugural pneumocystis pneumonia pneumonia. impact of triple antiretroviral therapy]. | to evaluate the impact of the advent of triple combination therapy for aids on the nature of the first aids-definiting event, a retrospective study was conducted in the infectious diseases department of the croix-rousse teaching hospital in lyon, france. the 280 patients entered in the aids registry of the department between january 1, 1994, and august 31, 1998, were studied. in 1994 and 1995, 33.05% of registry entries were for a first aids-defining event. after the introduction of triple combi ... | 1999 | 10418042 |
| etiology, clinical features and outcome of splenic microabscesses in hiv-infected patients with prolonged fever. | a prospective study was conducted to determine the etiology, clinical features, and outcome in a series of 32 consecutively enrolled hiv-infected patients with prolonged fever in whom high resolution (7.5 mhz) sonography revealed multiple splenic microabscesses. conventional (3.5 mhz) sonography showed no splenic abnormalities in any patients. the diagnoses were: tuberculosis (14), visceral leishmaniasis (7), disseminated mycobacterium avium complex infection (5), salmonella spp. bacteremia (2), ... | 1999 | 10421038 |
| adherence to guidelines for antiretroviral therapy and for preventing opportunistic infections in hiv-infected adults and adolescents in ryan white-funded facilities in the united states. | to determine adherence by health care providers to guidelines for antiretroviral therapy and for prevention of opportunistic infections (ois) in adults with hiv infection in federally funded facilities in the united states, we reviewed records of hiv-infected adults (>13 years) in 11 ryan white title iii facilities in four states for information on eight standard-of-care recommendations during november 1996 through september 1997. eligibility required a visit to the facility within 6 months befo ... | 1999 | 10421247 |
| downward trends in bronchoscopies performed between 1991 and 1997. | to examine the frequency of bronchoscopy performance in a large tertiary medical center over a period of 8 years. | 1999 | 10424532 |
| clinical presentation of hospitalized adult patients with hiv infection and aids in bangkok, thailand. | to characterize the clinical spectrum of disease and immune status of adult hiv-1-infected patients in bangkok. | 1999 | 10428112 |
| inhibition of hiv-1 tat-tar interaction by diphenylfuran derivatives: effects of the terminal basic side chains. | a series of four biscationic diphenylfuran derivatives was used to investigate drug binding to the transactivation response element (tar) rna. the drugs, which are active against the pneumocystis carinii pathogen (pcp), differ by the nature of the terminal basic side chains. furimidazoline (db60) is more potent at inhibiting binding of the tat protein to tar than furamidine (db75) and the amidine-substituted analogues db244 and db226. in vivo studies using the fusion-induced gene stimulation (fi ... | 1999 | 10428378 |
| aids-related pneumocystis carinii pneumonia in the era of adjunctive steroids: implication of bal neutrophilia. | factors predictive of mortality in patients with aids and pneumocystis carinii pneumonia (pcp) were identified before the introduction of adjunctive steroids, but they have not been reevaluated since. because pcp still occurs in aids, remaining fatal in some cases, we conducted a multivariate analysis of factors predicting mortality in patients with hiv-positive pcp managed from 1990 to 1995, i.e., after the consensus conference on the use of adjunctive steroids. the predictive value of clinical ... | 1999 | 10430719 |
| factors that predict incomplete virological response to protease inhibitor-based antiretroviral therapy. | many patients infected with human immunodeficiency virus type 1 (hiv-1) have suboptimal responses to protease inhibitor-based therapy. we retrospectively evaluated a cohort of 104 hiv-positive adults, most of whom had previously received antiretrovirals, to identify the frequency and clinical predictors of incomplete response to potent hiv-1 protease inhibitors. sixty-two (60%) of the patients had an incomplete response, defined as a plasma hiv-1 rna level of >400 copies/ml after 20 weeks of the ... | 1999 | 10433568 |
| in situ detection of aspergillus 18s ribosomal rna in invasive pulmonary aspergillosis. | we attempted to evaluate the usefulness of in situ hybridization (ish) in the specific diagnosis of aspergillus pulmonary infection. | 1999 | 10435362 |
| fever of undetermined origin in patients with the acquired immunodeficiency syndrome in brazil: report on 55 cases. | the medical records of patients with aids admitted to a general hospital in brazil from 1989 to 1997 were reviewed retrospectively with the aim at defining the frequency and etiology of fever of undetermined origin (fuo) in hiv-infected patients of a tropical country and to evaluate the usefulness of the main diagnostic procedures. 188 (58.4%) out of 322 patients reported fever at admission to hospital and 55 (17.1%) had fuo. those with fuo had a mean cd4+ cell count of 98/ml. a cause of fever w ... | 1999 | 10436667 |
| [pneumocystosis: progress in diagnosis and treatment]. | in the paper we have presented taxonomy of pneumocystis carinii, the way of infection transmission and risk factors for pneumocystosis. the clinical picture, contemporary treatment and prophylaxis methods, especially in hiv-positive patients have been described too. we have taken into consideration the problem of reinfection and reactivation of pneumocystosis. | 1999 | 10437404 |
| chemoprophylaxis for pneumocystis carinii pneumonia. | 1999 | 10440453 | |
| atypical wegener's granulomatosis with positive cytoplasmic antineutrophil cytoplasmic antibodies, ophthalmologic manifestations, and slowly progressive renal failure without respiratory tract involvement. | a 68-year-old woman had microscopic hematuria and proteinuria since the age of 50. she also had hearing impairment, arthralgia, retinal embolism, peripheral arterial occlusion of the right foot and chronic renal failure during the course. at the age of 68, she had progressive renal failure and nephrotic syndrome with high titers of serum cytoplasmic antineutrophil cytoplasmic antibodies (c-anca). no evidence of respiratory tract involvement was found. methylprednisolone pulse therapy and low dos ... | 1999 | 10440508 |
| pneumocystis carinii pneumonia in hiv infected patients from south africa. | to compare the spectrum of pulmonary disease in human immunodeficiency virus positive patients of african and european origin, with particular reference to pneumocystis carinii pneumonia. | 1999 | 10442127 |
| nocardial infection in a renal transplant recipient on tacrolimus and mycophenolate mofetil. | infection with nocardia spp. is an uncommon but important cause of morbidity and mortality in organ transplant recipients. cotrimoxazole prophylaxis against urinary tract infection and pneumocystis carinii pneumonia in these patients usually prevents nocardial infection also. we report the case of a patient on tacrolimus and mycophenolate mofetil who developed drug-induced diabetes mellitus followed by nocardial brain infection. this infection occurred despite conventional cotrimoxazole prophyla ... | 1999 | 10442495 |
| pneumocystis carinii pneumonia in a 15-year-old with chronic mucocutaneous candidiasis. | a 15-y-old male patient with chronic mucocutaneous candidiasis (cmcc) and new onset adrenal insufficiency developed pneumocystis carinii pneumonia (pcp). the literature on infectious complications of cmcc is reviewed and clinical and laboratory characteristics of the only previously described case of pcp in cmcc are compared with those of the patient reported here. | 1999 | 10447335 |
| protection from pneumocystis carinii pneumonia. | 1999 | 10448407 | |
| trends in perinatal transmission of hiv/aids in the united states. | since 1994, the us public health service (phs) has recommended routine, voluntary prenatal human immunodeficiency virus (hiv) testing and zidovudine therapy to reduce perinatal hiv transmission. | 1999 | 10450714 |
| pneumocystis carinii pneumonia mimicking wegener's granulomatosis. | 1999 | 10452656 | |
| the accuracy of non-bronchoscopic bronchoalveolar lavage in the diagnosis of pneumocystis carinii pneumonia in children. | 1999 | 10453137 | |
| plasma hiv viral load in patients with hemophilia and late-stage hiv disease: a measure of current immune suppression. multicenter hemophilia cohort study. | for patients infected with hiv, plasma hiv viral load in early disease predicts long-term prognosis. however, the implications of viral load measurements late in hiv disease are uncertain. | 1999 | 10454946 |
| pneumocystis carinii major surface glycoprotein induces interleukin-8 and monocyte chemoattractant protein-1 release from a human alveolar epithelial cell line. | the major surface glycoprotein (msg) is an abundant, immunogenic glycoprotein located on the surface of pneumocystis carinii. little is known about the proinflammatory effects of msg. | 1999 | 10457157 |
| changes in aids-defining illnesses in a london clinic, 1987-1998. | to describe the incidence of aids-defining illnesses within a single large clinic setting, to describe temporal changes over a 10-year period in the overall incidence and of individual aids-defining illnesses and to investigate the impact of hiv treatment regimen on the incidence of aids-defining illnesses. | 1999 | 10458621 |
| effect on parasite eradication of pneumocystis carinii-specific antibodies produced in the presence or absence of cd4(+) alphabeta t lymphocytes. | the contribution of specific antibodies (ab) to successful clearance of pneumocystis carinii from host pulmonary tissues has received increasing attention. sera collected from diseased recombinase-activating gene (rag)-1(-/-), tcrbetaxdelta(-/-), tcrbeta(-/-) and abeta(-/-) mutants as well as from aerogenic parasite-exposed (aero) and intranasally (i. n.) infected c57bl/6 mice were transferred to rag-1(-/-) mutants inoculated with freshly isolated parasites. all sera, except for rag-1(-/-) serum ... | 1999 | 10458760 |
| dna amplification of nasopharyngeal aspirates in rats: a procedure to detect pneumocystis carinii. | the diagnosis of pneumocystis carinii pneumonia (pcp) requires invasive methods of bronchoalveolar lavage and lung biopsy. in this study, we examined efficacy of polymerase chain reaction (pcr) compared to giemsa and silver ammoniacal staining to detect p. carinii in easily accessible extrapulmonary sites as well as lung. samples were collected from lung, nasal and pharyngeal aspirates, gastric contents, urine and blood from dexamethasone treated or untreated virus-free sprague-dawley rats. all ... | 1999 | 10458922 |
| icu admission in patients infected with the human immunodeficiency virus - a multicentre survey. | we conducted a retrospective study to assess the reasons for admission to the intensive care unit, and subsequent outcome, in patients infected with the human immunodeficiency virus (hiv). four hospitals in the south of england participated, all with specialist hiv units. data were collected on 127 patients admitted to icu on 133 separate occasions between june 1993 and october 1997. the mean age on admission was 38 years (range 23-60 years). ninety-four patients (70.7%) were documented hiv-posi ... | 1999 | 10460523 |
| [a search for the focus in patients with fever of unknown origin: is positron-emission tomography with f-18-fluorodeoxyglucose helpful?]. | search for focus in patients with fever of unknown origin (fuo). | 1999 | 10464505 |
| [withdrawal of pneumocystis carinii pneumonia prophylaxis in patients receiving efficacious combined antiretroviral treatment. study of 85 cases]. | to analyse the incidence of pneumocystis carinii pneumonia after the withdrawal of prophylaxis, in patients with aids who were receiving haart (highly active antiretroviral treatment). | 1999 | 10464742 |
| pneumocystis carinii pneumonia in hiv-infected patients: effect of steroid therapy on surfactant level. | previous studies have suggested alterations in pulmonary surfactant lipid in the setting of pneumocystis carinii pneumonia in hiv-infected patients. because pulmonary surfactant lipid is composed of a variety of lipid products and because other phospholipids might be present in bronchoalveolar lavage (bal) lipid determinations, a single molecular species of phospholipid which comprises a substantial portion of the surfactant lipid fraction, dipalmitoyl phosphatidylcholine (dppc), was measured by ... | 1999 | 10464817 |
| inhibition of dihydrofolate reductases from toxoplasma gondii, pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine. | twenty-one conformationally restricted tricyclic pyrimethamine and metoprine analogues with one or two chlorine atoms, or other substituents, at different positions of the phenyl ring were tested for potency and species selectivity against dihydrofolate reductase (dhfr) from toxoplasma gondii, pneumocystis carinii, and rat liver. heterocyclic systems studied included indeno[2,1-d]pyrimidines, benzo[f]quinazolines, and benzo[3,4]cyclohepta[1,2-d]pyrimidines. all but one of the analogues were more ... | 1999 | 10466054 |
| diagnosis of pneumocystis carinii pneumonia: immunofluorescence staining, simple pcr or npcr. | to compare immunofluorescence (if) test, routinely used in the department for the detection of pnemocystis carinni with simple polymerase chain reaction (pcr) and nested pcr (npcr) methods: bronchoalveolar lavage (bal) and induced sputum (is) specimens from hiv-positive (39), lung transplant ssart transplant (2), and one each from non-hodgkin's lymphoma, drug addict and a premature baby were screened by if test, simple pcr and npcr for the presence of p.carinii. | 1999 | 10468133 |
| [antiinfectious prophylaxis in pediatric oncology. work group "quality assurance" of society for pediatric oncology and hematology (gpoh)]. | infections in disease- and/or chemotherapy-related neutropenia are major, often emergency-type problems in the treatment of pediatric oncology patients and explain the ongoing discussion about antiinfectious prophylaxis. the different aspects of prophylaxis and an overview on the literature are presented. antiinfectious prophylaxis in pediatric oncology includes the following issues: 1. general aspects such as information for patients and parents on neutropenia and risk of infectious diseases an ... | 1999 | 10472574 |
| exposure of health care workers to pentamidine isethionate. | pentamidine isethionate is currently used for the prophylaxis and treatment of pneumocystis carinii pneumonia. its use has been associated with a number of symptoms in staff administering treatment, and there are some additional concerns about possible adverse health effects of long term exposure. the aim of this study was to quantify exposure of health care staff administering nebulized pentamidine to patients. personal breathing zone and static air samples at the height of the patient's head w ... | 1999 | 10474916 |
| changing conditions and treatments in a dynamic cohort of ambulatory hiv patients: the hiv outpatient study (hops). | most hiv-infected persons are now treated as ambulatory patients. obtaining continually updated data about these patients' changing conditions, therapies, and reimbursement is essential to health care provision and planning. the systematic tracking of patient medical and laboratory information in an ongoing commercial data collection program (the health research network) allows clinicians to better understand health outcomes, practice patterns, and epidemiologic trends for their patients. | 1999 | 10475534 |
| long-term course and outcome in aids patients with cerebral toxoplasmosis. | we compared clinical long-term course and outcome in all aids patients admitted to our outpatient department from january, 1989 to june, 1998 with toxoplasma encephalitis (te) as first aids-defining infection (n= 106) and in 106 patients with pneumocystis carinii pneumonia (pcp) as first aids-defining disease. | 1999 | 10478582 |
| [pneumocystis carinii pneumonia in an immunocompetent patient after paraquat spraying]. | 1999 | 10481343 | |
| [clinical manifestations, diagnosis and course of pneumocystis carinii pneumonia in patients with hematologic diseases]. | to characterize clinical, diagnostic and course features of pneumonia caused by pneumocystis carinii (pc) in hematologic inpatients. | 1999 | 10481865 |
| c-reactive protein levels in hiv complicated by opportunistic infections and infections with common bacterial pathogens. | in order to determine the pattern of c-reactive protein (crp) concentrations in hiv-infected patients with various other infections, we conducted a prospective study (for the period 1990-91) of all hiv-seropositive patients hospitalized with fever and a retrospective study (for the period 1990-95) of all patients infected with mycobacterium avium complex (mac) and pneumocystis carinii pneumonia (pcp). samples from blood, cerebrospinal fluid and sites with clinical signs of infection were obtaine ... | 1999 | 10482049 |
| [causes of death (1983-1997) in patients infected with human immunodeficiency virus by contaminated blood coagulation factor products: report of the clinical study group on prevention and treatments of hiv infection]. | our group conducted a national survey of patients who had died of acquired immunodeficiency syndrome (aids) after being infected with human immunodeficiency virus type 1 (hiv-1) by contaminated blood coagulation factor products. a total of 1446 hospitals, clinics, and other health-care institutions throughout japan were enrolled in the study, which was supported by the japanese government ministry of health and welfare with a health sciences grant for research on hiv/aids. of the 1434 registered ... | 1999 | 10483137 |
| [changes of knowledge of hiv-positivity before development of aids among danish patients with aids 1988-1997]. | we describe the changes in the period of knowledge of hiv positivity before aids in the light of the new anti-retroviral treatment regime among all notified danish aids patients 1988-1997. overall, 29% of the patients were diagnosed with aids less than four months after the first positive hiv test, a proportion that decreased through 1988-1995, but then increased. however, the proportion with over five years between positive hiv test and aids diagnosis increased from 9% in 1988-1990 to 48% in 19 ... | 1999 | 10485207 |
| pneumocystis carinii carriage in immunocompetent patients with primary pulmonary disorders as detected by single or nested pcr. | ninety-five bronchoalveolar lavage specimens from 63 immunocompetent adult patients with primary pulmonary disease were analyzed for pneumocystis carinii colonization by primary and nested pcr. twelve of 63 patients (19%) were pcr positive. none of them developed p. carinii pneumonia. these results suggest that p. carinii carriage may exist in immunocompetent patients with underlying pulmonary disease. | 1999 | 10488221 |
| efficacy of azithromycin in prevention of pneumocystis carinii pneumonia: a randomised trial. california collaborative treatment group. | azithromycin in combination with sulphonamides is active against pneumocystis carinii pneumonia (pcp) in animals. we assessed the clinical efficacy of azithromycin for pcp prophylaxis in human beings. | 1999 | 10489947 |
| nodular pneumocystis carinii pneumonia in siv-infected macaques. | pneumocystis carinii (pc) pneumonia is a frequent manifestation of the acquired immunodeficiency syndrome (aids) in humans and macaques. an unusual nodular type of pc pneumonia was observed in two simian immunodeficiency virus (siv)-inoculated rhesus macaques (macaca mulatta). these animals developed clinical signs of simian aids, including anorexia, weight loss, dyspnea, and collapse. grossly, both animals had multifocal tan-white nodules 1-10 mm in diameter scattered throughout the lungs. one ... | 1999 | 10490219 |
| risk factors for early hospital readmission in patients with aids and pneumonia. | to determine risk factors for early readmission to the hospital in patients with aids and pneumonia. | 1999 | 10491241 |
| type-ii major-surface-glycoprotein family of pneumocystis carinii under the control of novel expression elements. | pneumocystis carinii are coated by abundant surface proteins, named msgs for major surface glycoproteins, that undergo antigenic variation. there are many msg genes on the chromosomes but the msg expression site is restricted to a unique site called type-i ucs, and silent msg genes can be translocated to the expression site by dna recombination. we have reported previously the existence of alternative ucs elements named type-ii ucs by msg transcript analyses (j. infect. dis., 171, 1563-1568 [199 ... | 1999 | 10492167 |
| pneumocystis carinii infection in human immunodeficiency virus-positive patients. | pneumocystis carinii is a ubiquitous, atypical unicellular fungus. p. carinii pneumonia (pcp) is responsible for considerable morbidity and mortality in acquired immune deficiency syndrome (aids) patients, and is the leading complication in advanced human immunodeficiency virus (hiv) infection. many different host (mammal)-specific species of pneumocystis exist, but the life-cycle is not understood fully. human strains are designated as p. carinii f. sp. (special form) hominis (at least 59 diffe ... | 1999 | 10492914 |
| pneumocystis carinii presenting as a mediastinal mass in a child with acquired immunodeficiency syndrome. | 1999 | 10493348 | |
| hypercalcemia as an early sign of lymphoma in a patient with acquired immunodeficiency syndrome (aids). | hypercalcemia is uncommon in patients infected with the human immunodeficiency virus (hiv). it has been described in association with cytomegalovirus infection, pneumocystis carinii pneumonia, granulomatous diseases, and lymphoma. however, symptomatic hypercalcemia as an early sign of an underlying aids-related lymphoma is not well documented. we discuss the case of a patient with hiv and hypercalcemia, leading to the diagnosis of an underlying lymphoma. the hypercalcemia was associated with a s ... | 1999 | 10498174 |
| the association between primary source of ambulatory care and access to and outcomes of treatment among aids patients. | to examine the relationship between having a primary source of ambulatory care (psac), access to aids treatment and prophylaxis for opportunistic infection, and hospital and mortality outcomes among heterosexual men and women with aids. | 1999 | 10501599 |
| chemotherapy with etoposide, vincristine, doxorubicin, bolus cyclophosphamide, and oral prednisone in patients with refractory cutaneous t-cell lymphoma. | this phase ii study was undertaken to assess the efficacy and toxicity of chemotherapy with etoposide, vincristine, doxorubicin, bolus cyclophosphamide, and oral prednisone (epoch regimen) in patients with advanced, refractory cutaneous t-cell lymphoma (ctcl). | 1999 | 10506727 |
| is pneumocystis carinii vertically transmitted to neonatal rats? | pneumocystis carinii is a pulmonary pathogen of immunocompromised humans or other mammals. its infection results from activation of organisms involved in latent infection or from new infection through the air. almost all children are known to be infected within 2 to 4 years of birth, though prenatal transplacental transmission has not yet been demonstrated. in this study we observed experimental p. carinii infection in neonatal rats, thus investigating the possibility of transplacental vertical ... | 1999 | 10507222 |
| prodrugs for amidines: synthesis and anti-pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan. | syntheses of several carbamate analogues of 2, 5-bis(4-amidinophenyl)furan (1) under mild conditions and their evaluation as prodrugs against pneumocystis carinii pneumonia (pcp) in an immunosuppressed rat model are described. thus, nine new bis-carbamates: methoxycarbonyl (2), 2,2,2-trichloroethoxycarbonyl (3), ethylthiocarbonyl (4), benzyloxycarbonyl (5), (4-methyl-2-oxo-1, 3-dioxol-4-en-5-yl)methoxycarbonyl (6), phenoxycarbonyl (7), 4-fluorophenoxycarbonyl (8), 4-methoxyphenoxycarbonyl (9), a ... | 1999 | 10508447 |
| can chemoprophylaxis against opportunistic infections be discontinued after an increase in cd4 cells induced by highly active antiretroviral therapy? | in the 'usphs/idsa guidelines for prevention of opportunistic infections in persons infected with human immunodeficiency virus', the indications for chemoprophylaxis are based on nadir cd4 cell count. many patients have, however, experienced an increase in cd4 cell count after the introduction of highly active antiretroviral therapy (haart). | 1999 | 10509565 |
| effects of antiretroviral therapy and opportunistic illness primary chemoprophylaxis on survival after aids diagnosis. adult/adolescent spectrum of disease group. | to examine the effects of antiretroviral therapy (art) and opportunistic illness chemoprophylaxis on the survival of persons with aids and survival time based on year of aids diagnosis. | 1999 | 10509570 |
| oropharyngeal samples for genotyping and monitoring response to treatment in aids patients with pneumocystis carinii pneumonia. | a nested pcr, amplifying a portion of the gene encoding the mitochondrial large subunit ribosomal rna (mt lsu rrna) of pneumocystis carinii sp. f. hominis was applied to oropharyngeal samples obtained on repeated occasions from 12 hiv-infected patients with p. carinii pneumonia (pcp) to monitor response to anti-p. carinii treatment. genotyping of p. carinii sp. f. hominis was also performed on paired samples of oropharyngeal and broncho-alveolar lavage samples before the start of treatment, and ... | 1999 | 10510966 |
| in-vitro activity of polycationic peptides against cryptosporidium parvum, pneumocystis carinii and yeast clinical isolates. | the in-vitro activity of magainin ii, indolicidin and ranalexin against 14 clinical isolates of eukaryotic microorganisms was evaluated. antifungal susceptibility testing was performed by broth microdilution, and activity against pneumocystis carinii and cryptosporidium parvum was determined by inoculation on to cell monolayers. for yeasts, peptide mics and mfcs ranged from 6.25 to > 50 mg/l. ranalexin showed the highest activity against candida spp., while magainin ii demonstrated greatest anti ... | 1999 | 10511411 |
| imaging features of pneumocystis carinii pneumonia. | despite a declining prevalence secondary to improved prophylaxis, pneumocystis carinii remains an important pulmonary pathogen in the immunocompromised host. because the radiologist is often the first to suggest the diagnosis of pcp, an awareness of the entire spectrum of imaging features associated with this organism is important. the classic presentation of pcp is a bilateral interstitial pattern, which may be characterized as finely granular, reticular, or ground-glass opacities. when chest r ... | 1999 | 10514937 |
| a prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/sulfamethoxazole as pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation. | pneumonia due to pneumocystis carinii is an infrequent complication following autologous stem cell transplantation (asct) which is associated with a high mortality. although administration of trimethoprim/sulfa- methoxazole (tmp/smx) is an effective prophylactic strategy for pneumocystis carinii pneumonia (pcp), treatment-associated toxicity frequently results in discontinuation of therapy. we have conducted a prospective randomized trial comparing atovaquone, a new anti-pneumocystis agent, with ... | 1999 | 10516703 |
| [hepatic and pancreatic disease in patients with acquired immunodeficiency syndrome (aids)]. | aids is frequently expressed through gastrointestinal o abdominal symptoms. in addition, patients with aids or arc frequently have hepatic and biliary symptoms, while pancreatic alterations are found in 4-30% of patients hospitalised for aids. since aids patients are immunodepressed, they are subject to opportunistic infection often multifocal and the pathological processes can be present simultaneously. about 2/3 of patients have enlarged liver, steatosis, splenomegaly, lymphoadenopathy, cholec ... | 1999 | 10518957 |
| new trend in the epidemiology of pneumocystis carinii pneumonia (pcp) among aids patients. | 1999 | 10519263 | |
| impaction versus filtration for the detection of pneumocystis carinii dna in air. | 1999 | 10519264 | |
| acquisition and biodiversity of pneumocystis carinii in a colony of wild rabbits (oryctolagus cuniculus). | 1999 | 10519266 | |
| comparison of four methods for extraction of pneumocystis carinii dna from pulmonary specimens and serum. | 1999 | 10519267 | |
| evaluation of a nested pcr for detection of pneumocystis carinii in serum from immunocompromised patients. | 1999 | 10519268 | |
| biomolecular approach for pneumocystis carinii pneumonia (pcp) diagnosis and follow up in aids patients. | 1999 | 10519269 | |
| interactions of two pneumocystis carinii populations within rat lungs. | 1999 | 10519270 | |
| pneumocystis carinii trophozoites in the lungs of patients without pneumocystosis. | 1999 | 10519271 | |
| the minimum number of pneumocystis carinii f. sp. carinii organisms required to establish infections is very low. | 1999 | 10519272 | |
| experimental inoculation of immunosuppressed owl monkeys with pneumocystis carinii f. sp. hominis. | 1999 | 10519274 | |
| pneumocystis carinii growth kinetics in culture systems and in hosts: involvement of each life cycle parasite stage. | 1999 | 10519275 | |
| ability of pneumocystis carinii cysts to seed cultures and infect animals. | 1999 | 10519276 | |
| mouse derived pneumocystis carinii in an axenic culture system. | 1999 | 10519277 | |
| culture of pneumocystis carinii sp.f. hominis. | 1999 | 10519278 | |
| distribution and biosynthesis of cis-9,10-epoxystearic acid in pneumocystis carinii. | 1999 | 10519279 | |
| type-ii major-surface-glycoprotein family of pneumocystis carinii. | 1999 | 10519280 | |
| direct correlation of genomic localization and surface expression of the major surface glycoprotein of pneumocystis carinii. | 1999 | 10519281 | |
| determination of the maximum frequency of genetic rearrangements associated with pneumocystis carinii surface antigen variation. | 1999 | 10519282 | |
| characterization of the cdc25 phosphatase in pneumocystis carinii. | 1999 | 10519283 | |
| cdc2 gene of pneumocystis carinii hominis and its expression during culture. | 1999 | 10519284 | |
| assembly of cell wall glucans by pneumocystis carinii: characterization of the gsc-1 subunit mediating beta-glucan synthesis. | 1999 | 10519285 | |
| identification of dihydropteroate (dhps) gene mutant in pneumocystis carinii in respiratory samples of hiv+ patients from 1992 to 1997. | 1999 | 10519286 | |
| contribution of dihydropteroate synthase gene typing for pneumocystis carinii f.sp. hominis epidemiology. | 1999 | 10519287 | |
| successful treatment of pcp episodes caused by pneumocystis carinii with mutant dihydropteroate (dhps) gene. | 1999 | 10519288 | |
| recombinant major surface glycoprotein of pneumocystis carinii elicits a specific immune response but is not protective in immunosuppressed rats. | 1999 | 10519289 | |
| effects of sterol inhibitors on the atp content of pneumocystis carinii. | 1999 | 10519292 | |
| beta-glucan from pneumocystis carinii stimulates tnf alpha release from alveolar macrophages. | 1999 | 10519294 | |
| production of plasminogen activator by alveolar macrophages in experimental pneumocystis carinii pneumonia. | 1999 | 10519296 | |
| immunological characterization of surface subtilisin-like protease (ssp) of pneumocystis carinii. | 1999 | 10519297 | |
| [infectious complications of heart transplantation. a prospective study for the first 6 years of a transplantation program]. | to study the infectious complications, mortality, and associated factors in heart transplant recipients. | 1999 | 10522428 |
| [clinico-radiological correlation of pulmonary complications of pediatric hiv infection]. | fifty-five percent of children with hiv infection, aged two months to ten years, were admitted at our hospitals because of respiratory conditions. pulmonary complications found at admission in these children were lymphoid interstitial pneumonitis, pneumocystis carinii pneumonia, fungal over-infection, tuberculosis, and bacterial complications. also, non-specific infectious bronchial conditions, probably of viral origin. the most representative chest-x rays of these pulmonary conditions were anal ... | 1999 | 10522429 |