Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [to screen or to prevent cervical carcinoma?]. | 2008 | 18068908 | |
| [vaccination against human papillomavirus. an new prevention strategy against cancer]. | 2008 | 18081051 | |
| comprehensive comparison of the interaction of the e2 master regulator with its cognate target dna sites in 73 human papillomavirus types by sequence statistics. | mucosal human papillomaviruses (hpvs) are etiological agents of oral, anal and genital cancer. properties of high- and low-risk hpv types cannot be reduced to discrete molecular traits. the e2 protein regulates viral replication and transcription through a finely tuned interaction with four sites at the upstream regulatory region of the genome. a computational study of the e2-dna interaction in all 73 types within the alpha papillomavirus genus, including all known mucosal types, indicates that ... | 2008 | 18084026 |
| inhibition of hpv-16 l1 expression from l1 cdnas correlates with the presence of hnrnp a1 binding sites in the l1 coding region. | the human papillomavirus type 16 (hpv-16) l1 capsid protein is very poorly expressed from cdna expression plasmids transiently transfected into mammalian cells. the results described herein demonstrate that inhibition of hpv-16 l1 expression from l1 cdnas correlates with the presence of splicing regulatory sequences in the l1 coding region. this inhibitory effect correlates with the binding of hnrnp a1 to the rna elements. similar to unutilised splice sites that may retain mrnas in the nucleus, ... | 2008 | 18040766 |
| the regulatory element in the 3'-untranslated region of human papillomavirus 16 inhibits expression by binding cug-binding protein 1. | the 3'-untranslated regions (utrs) of human papillomavirus 16 (hpv16) and bovine papillomavirus 1 (bpv1) contain a negative regulatory element (nre) that inhibits viral late gene expression. the bpv1 nre consists of a single 9-nucleotide (nt) u1 small nuclear ribonucleoprotein (snrnp) base pairing site (herein called a u1 binding site) that via u1 snrnp binding leads to inhibition of the late poly(a) site. the 79-nt hpv16 nre is far more complicated, consisting of 4 overlapping very weak u1 bind ... | 2008 | 18042543 |
| tonsil t cell immunity to human papillomavirus in the absence of detectable virus in healthy adults. | human papillomavirus (hpv) is known to infect the epithelium of the upper aerodigestive tract; however, major questions regarding prevalence and persistence of infection, and their relation to local immune response, remain unanswered. | 2008 | 18043489 |
| recurrent respiratory papillomatosis: an overview of current thinking and treatment. | human papillomaviruses (hpv) infection in benign laryngeal papillomas is well established. the vast majority of recurrent respiratory papillomatosis lesions are due to hpv types 6 and 11. human papillomaviruses are small non-enveloped viruses (>8 kb), that replicate within the nuclei of infected host cells. infected host basal cell keratinocytes and papillomas arise from the disordered proliferation of these differentiating keratinocytes. surgical debulking of papillomas is currently the treatme ... | 2008 | 18046565 |
| evaluation of two types of sponges used to collect cervical secretions and assessment of antibody extraction protocols for recovery of neutralizing anti-human papillomavirus type 16 antibodies. | immunogenicity evaluations in human papillomavirus (hpv) vaccine trials have relied on serological samples, yet cervical antibodies are likely to be most relevant for protection against infection. in order to assess functional antibody levels at the cervix, the secreted-alkaline-phosphatase neutralization assay (seapna) was used to measure hpv-neutralizing activity. we assessed the variability of the seapna with serum samples after vaccination with an hpv type 16 (hpv16) l1 virus-like particle v ... | 2008 | 18032596 |
| comparison of amplicor and hybrid capture ii assays for high risk hpv detection in normal and abnormal liquid-based cytology: use of inno-lipa genotyping assay to screen the discordant results. | the study was aimed to evaluate the feasibility of detecting human papillomavirus (hpv) in women with normal or abnormal cervical smears using the roche amplicor mwp hpv test. we compared by amplicor test and hybrid capture ii (hcii) test, the prevalence of hr-hpv in 470 cervical samples including 55 samples with wnl cytology, 208 asc-us, 193 lgsil and 14 hgsil. samples with discordant results were retested with inno-lipa genotyping hpv test v2. the hr-hpv positivity in wnl cytology samples was ... | 2008 | 18036888 |
| molecular techniques in cytopathology practice. | in the last decade, new molecular techniques were introduced into pathology laboratories. cytology also benefited from the innovations emerging from this new era. molecular cytopathology (mcp) can be defined as molecular studies applied on all types of cytological specimens, namely gynaecology cytology, exfoliative non- gynaecology cytology and fine needle aspirates. the development of many new ancillary techniques has paralleled the emergence of clinical cytology as a major diagnostic specialty ... | 2008 | 18037664 |
| members of the human papillomavirus type 18 family (alpha-7 species) share a common association with adenocarcinoma of the cervix. | 2008 | 18059025 | |
| rna interference against hpv16 e7 oncogene leads to viral e6 and e7 suppression in cervical cancer cells and apoptosis via upregulation of rb and p53. | the simultaneous expression of human papillomavirus type 16 (hpv16) e6 and e7 oncogenes is pivotal for malignant transformation and maintenance of malignant phenotypes. silencing these oncogenes is considered to be applicable in molecular therapies of human cervical cancer. however, it remains to be determined whether hpv16 e6 and e7 could be both silenced to obtain most efficient antitumor activity by using rna interference (rnai) technology. herein, we designed a small interfering rna (sirna) ... | 2008 | 18060502 |
| down-regulation of transforming growth factor-beta type ii receptor (tgf-betarii) protein and mrna expression in cervical cancer. | cervical carcinogenesis is a multistep process initiated by "high risk" human papillomaviruses (hr-hpv), most commonly hpv16. the infection per se is, however, not sufficient to induce malignant conversion. transforming growth factor beta (tgf-beta) inhibits epithelial proliferation and altered expression of tgf-beta or its receptors may be important in carcinogenesis. one cofactor candidate to initiate neoplasia in cervical cancer is the prolonged exposure to sex hormones. interestingly, previo ... | 2008 | 18184435 |
| placental infection with human papillomavirus is associated with spontaneous preterm delivery. | we sought to determine if human papillomavirus (hpv) infection of extravillous trophoblast cells reduces cell invasion and if placental infection is associated with adverse reproductive outcomes attributed to placental dysfunction. | 2008 | 18184644 |
| detection of human papillomavirus dna in cutaneous squamous cell carcinoma among immunocompetent individuals. | the presence of certain types of human papillomavirus (hpv) is a known risk factor for the development of anogenital squamous cell carcinomas (sccs). a similar association has been hypothesized for cutaneous sccs, although, to our knowledge, no studies to date have combined sensitive hpv dna detection techniques with epidemiologic data controlling for known risk factors to explore the association. we designed a case-control study examining hpv prevalence using highly sensitive pcr-detection assa ... | 2008 | 18185530 |
| evaluation of p16ink4a as a diagnostic tool in the triage of pap smears demonstrating atypical squamous cells of undetermined significance. | p16(ink4a) (p16) has emerged as a biomarker for the detection of high-risk human papillomavirus (hr-hpv) in papanicolaou (pap) smears. many studies have confirmed a strong correlation between p16 immunohistochemical positivity and high-grade squamous intraepithelial lesions (hsil) of the cervix. because p16 is predictive of hr-hpv and hsil, it seems plausible that p16 could be used as a diagnostic tool to triage atypical squamous cells of undetermined significance (ascus) pap smears. in this way ... | 2008 | 18186493 |
| [human papillomavirus vaccines]. | to assess the efficacy, the tolerance, the duration of protection and the limitations of papillomavirus vaccines and to determine the potential indications for prophylactic vaccination. | 2008 | 18187268 |
| human papillomavirus vaccine and cervical cancer prevention: practice and policy implications for pharmacists. | to review the epidemiology and natural history of human papillomavirus (hpv), summarize relevant clinical trials of the prophylactic hpv vaccines, and describe the practice and policy implications that hpv vaccine represents for pharmacists. | 2008 | 18192123 |
| prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma. | two independent pathways of vulvar carcinogenesis have currently been identified, one related to infection with mucosal human papillomaviruses (hpvs) and a second related to chronic inflammatory or autoimmune processes. the goal of the study was to examine a possible role of cutaneous hpvs from the beta genus in vulvar carcinogenesis and to evaluate the distribution of intratypic variants of hpv 16 in hpv 16-positive vulvar cancer. consecutive cases of vulvar carcinoma were retrieved from the fi ... | 2008 | 18192968 |
| development of a photodiode array biochip using a bipolar semiconductor and its application to detection of human papilloma virus. | we describe a dna microarray system using a bipolar integrated circuit photodiode array (pda) chip as a new platform for dna analysis. the pda chip comprises an 8 x 6 array of photodiodes each with a diameter of 600 microm. each photodiode element acts both as a support for an immobilizing probe dna and as a two-dimensional photodetector. the usefulness of the pda microarray platform is demonstrated by the detection of high-risk subtypes of human papilloma virus (hpv). the polymerase chain react ... | 2008 | 18193408 |
| short-fragment pcr assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation. | the aim of the study was to determine the prevalence and genotypes of hpv infection in laryngeal cancer specimens, normal mucosa obtained from the surgical margin and laryngeal nodules using a novel high sensitive and specific spf(10) hpv dna test, pcr/deia method and inno-lipa genotyping assay. the correlation between hpv presence and clinico-pathological features was analyzed. tissue samples were collected from 93 primary laryngeal squamous cell carcinoma (lscc), 49 specimens of normal mucosa ... | 2008 | 18193443 |
| [immunization schedule of the spanish association of pediatrics: recommendations 2008]. | the vaccine advisory committee of the spanish association of pediatrics provides information on the new developments in vaccines that have taken place in 2007, based on the available evidence, and discusses these developments. certain modifications to the immunization schedule for 2008 are recommended. a second varicella vaccine booster dose, administered together with the booster dose of the measles-mumps-rubella (mmr) vaccine when children start school (3-4 years), is recommended to avoid vacc ... | 2008 | 18194631 |
| [prevalence of genital hpv infection among women screened for cervical cancer]. | to assess the prevalence of high-risk genital human papillomavirus (hpv) infection by age group and risk factors associated. | 2008 | 18200349 |
| detection of cervical human papillomavirus infection in filter paper samples: a comparative study. | 2008 | 18201998 | |
| the p53 r72p polymorphism does not influence cervical cancer development in a portuguese population: a study in exfoliated cervical cells. | the interaction between the e6 protein of the high-risk human papillomaviruses (hpvs) with p53 seems to be crucial in cervical carcinogenesis. the presence of arg/arg genotype at codon 72 of tp53 gene was characterized as a risk factor in development of cervical cancer. however, the role of this polymorphism remains controversial and some authors suggested that the origin of dna (blood or exfoliated cervical cells) might influence these results. this study analyzed the effect of the p53 codon 72 ... | 2008 | 18205229 |
| tgf-beta1 and il-4 downregulate human papillomavirus-16 oncogene expression but have differential effects on the malignant phenotype of cervical carcinoma cells. | host immune response to human papillomavirus (hpv) is a crucial factor in viral clearance and control of persistent infections. the existence of an intercellular control mechanism mediated by cytokines to suppress hpv-gene transcription and to prevent malignant conversion of hpv-infected cells, has been postulated. in a previous study, we demonstrated the inhibitory activity of several cytokines on the hpv-16 long control region (lcr)-driven transcription; among these, il-4 was reported as a lcr ... | 2008 | 18206261 |
| patterns of genotype distribution in multiple human papillomavirus infections. | the relationship between severe-grade cervical lesions and clusters of human papillomavirus (hpv) genotypes in a taxonomic classification was surveyed in 232 women with previous abnormal cytology. hpv co-infections were clustered according to phylogenetic criteria. multiple infections were detected in 22.0% of the entire sample. clade a10 (represented by hpv-6 and hpv-11) appeared more frequently in multiple infections than clade a9, which was represented by five of the most common high-risk typ ... | 2008 | 18154550 |
| longitudinal cytological follow-up of patients with a papanicolaou test interpretation of "atypical squamous cells of undetermined significance" that was followed by a negative reflex test for high-risk human papillomavirus types. | the 2001 consensus guidelines essentially equated the follow-up management of patients with a papanicolaou (pap) test interpretation of negative for intraepithelial lesion or malignancy and those with an interpretation of atypical squamous cells of undetermined significance (asc-us) that was followed by a negative reflex test for high-risk human papillomavirus (hr hpv) types: follow-up cytology in 12 months. as several years have elapsed since these guidelines attained some measure of widespread ... | 2008 | 18156984 |
| infrared coagulator treatment of high-grade anal dysplasia in hiv-infected individuals: an aids malignancy consortium pilot study. | to evaluate prospectively the safety of the infrared coagulator (irc) as a treatment for anal high-grade squamous intraepithelial lesions (hsils) in hiv-infected individuals and to seek preliminary evidence for efficacy. | 2008 | 18156992 |
| interferon-gamma (ifn-gamma): a possible prognostic marker for clearance of high-risk human papillomavirus (hpv). | the goal of this study was to identify cytokines that may predict high-risk hpv clearance or persistence in untreated patients with mild dysplasia or less of the uterine cervix. | 2008 | 18164379 |
| type-dependent integration frequency of human papillomavirus genomes in cervical lesions. | chromosomal integration of high-risk human papillomavirus (hr-hpv) genomes is believed to represent a significant event in the pathogenesis of cervical cancer associated with progression from preneoplastic lesions to invasive carcinomas. this hypothesis is based on experimental data suggesting that integration-dependent disruption of hr-hpv e2 gene functions is important to achieve neoplastic transformation and on clinical data gathered by analyzing lesions induced by human papillomavirus (hpv) ... | 2008 | 18172324 |
| vaccinating adolescents in high-risk settings: lessons learned from experiences with hepatitis b vaccine. | meeting the health needs of adolescents who live in high-risk settings such as homeless shelters, migrant camps, juvenile detention centers, prisons, and other types of residential facilities presents many challenges. although there is no doubt that adolescents in many high-risk settings are at increased risk for hepatitis b and human papillomavirus, acute medical and psychological problems may consume all of the provider's time and resources. potential health threats such as vaccine-preventable ... | 2008 | 18174322 |
| projected cost-effectiveness of new vaccines for adolescents in the united states. | economic assessments that guide policy making on immunizations are becoming increasingly important in light of new and anticipated vaccines for adolescents. however, important considerations that limit the utility of these assessments, such as the diversity of approaches used, are often overlooked and should be better understood. | 2008 | 18174323 |
| time course of juvenile onset recurrent respiratory papillomatosis caused by human papillomavirus. | with the recent licensure of a new quadrivalent vaccine, many diseases caused by human papillomavirus (hpv) can now be prevented, including recurrent respiratory papillomatosis (rrp). the purpose of this study was to describe the burden and time course of juvenile onset rrp. | 2008 | 18174855 |
| [evaluation of accuracy of three assays for human papillomavirus detection and typing: hybrid capture 2, hpv consensus kit and amplicor hpv]. | detection of high-risk human papillomavirus has proved its usefulness in complement of abnormal cervical scrape result. the hybrid capture 2 (hc2, digene) test has proven its efficiency. we have compared this test with hpv consensus kit (hpvc, argène) and amplicor hpv test (ahpv, rochediagnostics) on a panel of 88 samples with low hc2 ratios or discordant results between hc2 and cervical scrape. | 2008 | 18178026 |
| human papilloma virus (hpv) status, p16ink4a, and p53 overexpression in epithelial malignant and borderline ovarian neoplasms. | this investigation is the first to evaluate simultaneously human papilloma virus (hpv) status, p16(ink4a), and p53 immunoreactivity in epithelial ovarian neoplasms. the results were analyzed and correlated with histological type, histological grade, and survival of patients. subtypes considered are papillary serous and mucinous. polymerase chain reaction (pcr) analysis, performed in our previous study, had already demonstrated a small number of hpv-positive epithelial ovarian neoplasms. no signi ... | 2008 | 18180113 |
| survey hints at uneven adoption of cancer vaccine. | 2008 | 18180705 | |
| regulation of telomerase and telomeres: human tumor viruses take control. | human tumor viruses are responsible for one-fifth of all cancers worldwide. these viruses have evolved multiple strategies to evade immune defenses and to persist in the host by establishing a latent infection. proliferation is necessary for pretumor cells to accumulate genetic alterations and to acquire a transformed phenotype. however, each cell division is associated with a progressive shortening of the telomeres, which can suppress tumor development by initiating senescence and irreversible ... | 2008 | 18182620 |
| transcriptional regulation of human papillomavirus type 18 p105 promoter by the co-activator cbp. | human papillomaviruses (hpvs) are the etiological agents of cervical cancer, with hpv-16 and 18 being the representative types of the higher risk group. the expression of the viral genes with transforming activity (e6 and e7) is controlled by the upstream regulatory region (urr), a segment of the viral genome that contains elements recognized by several transcription factors. | 2008 | 18182775 |
| hpv and cervical cancer: screening or vaccination? | following the demonstration of the superior validity of human papillomavirus (hpv) tests in screening for cervical cancer and the arrival of highly efficacious hpv 16 and 18 vaccines, cervical cancer prevention enters a time of sustainable introduction in developing countries. multidisciplinary efforts and novel protocols are being developed, and challenging situations are being faced to make cervical cancer, still the number two cancer in women worldwide, an eradicable condition. | 2008 | 18182975 |
| comparison of p16ink4a and hybrid capture 2 human papillomavirus testing as adjunctive tests in liquid-based gynecologic surepath preparations. | p16(ink4a), cyclin-dependent kinase inhibitor, is functionally inactivated in many tumors, including cervical cancer. we compared p16(ink4a) immunocytochemical staining and hybrid capture 2 (hcii) on surepath specimens using tissue biopsies (as the gold standard). their utility in a spectrum of atypical and preneoplastic lesions, and their ability to accurately identify underlying lesions of cin ii or greater was assessed using biopsy follow-up data. one-hundred and seventeen residual surepath s ... | 2008 | 18232003 |
| [effect of over expression of hpv18 e2 protein on apoptosis and secretion of macrophages]. | to study the effect of the over expression of gfp-e2, gfp-tad(n-extremity domain of hpv18 e2) and gfp-dbd (c-extremity domain of hpv18 e2) on the apoptosis and secretion of macrophages and to further explore the contribution of e2 gene to the uterine cervix cancer. | 2008 | 18237530 |
| regulation of human papillomavirus type 31 gene expression during the differentiation-dependent life cycle through histone modifications and transcription factor binding. | the life cycle of high-risk human papillomaviruses is linked to epithelial differentiation with virion production restricted to highly differentiated suprabasal cells. two major viral promoters direct high-risk hpv gene expression and their activities are dependent upon differentiation. the early promoter controls initiation of transcripts at sites upstream of the e6 open reading frame and is active in both undifferentiated as well as differentiated cells. the late viral promoter directs transcr ... | 2008 | 18237759 |
| human papillomavirus-related content in state and tribal comprehensive cancer control plans. | oncogenic types of the human papillomavirus (hpv) are firmly established as etiological agents for most premalignant and malignant epithelial lesions of the cervical mucosa. genital infection with hpv is the most common sexually transmitted infection (sti) in the united states. although most women infected with the virus become hpv negative within 2 years, women with persistent high-risk hpv infections are at greatest risk for developing cervical cancer. since the development of the papanicolau ... | 2008 | 18240976 |
| effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 dna methylation in cultured cell lines. | human papillomavirus-16 (hpv-16) genomes in cell culture and in situ are affected by polymorphic methylation patterns, which can repress the viral transcription. in order to understand some of the underlying mechanisms, we investigated changes of the methylation of hpv-16 dna in cell cultures in response to cellular differentiation, to recombination with cellular dna, and to an inhibitor of methylation. undifferentiated w12e cells, derived from a precancerous lesion, contained extrachromosomal h ... | 2008 | 18242658 |
| hpv triage testing or repeat pap smear for the management of atypical squamous cells (ascus) on pap smear: is there evidence of process utility? | a two-stage standard gamble was used to evaluate women's preferences for alternative managements of atypical squamous cells of undermined significance (ascus) on pap smear (repeat pap smear compared with immediate hpv test), and to test for the evidence of process utility. women's utilities for the health state scenarios were clustered towards the upper end of the 0-1 scale with considerable variability in women's preferences. there was evidence of process utility, with immediate human papilloma ... | 2008 | 17764095 |
| induction of mhc class i molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. | epigenetic events play an important role in tumour progression and also contribute to escape of the tumour from immune surveillance. in this study, we investigated the up-regulation of major histocompatibility complex (mhc) class i surface expression on tumour cells by epigenetic mechanisms using a murine tumour cell line expressing human e6 and e7 human papilloma virus 16 (hpv16) oncogenes and deficient in mhc class i expression, as a result of impaired antigen-presenting machinery (apm). treat ... | 2008 | 17725605 |
| comparison of the amplicor human papillomavirus test and the hybrid capture 2 assay for detection of high-risk human papillomavirus in women with abnormal pap smear. | infection with human papillomavirus (hpv) is a necessary step in the progression to cervical cancer. many methods for hpv testing are currently available, mostly developed to detect pools of hpv types. hybrid capture 2 (hc2) is one of the most widely used. a new pcr-based assay, the roche amplicor hpv test, has been recently developed. both assays recognize a group of 13 hr hpv types contemporaneously. this study evaluated the performance of both methods for detecting high-grade cervical lesions ... | 2008 | 17854914 |
| a novel splice donor site at nt 1534 is required for long-term maintenance of hpv31 genomes. | human papillomaviruses (hpv) are small double-stranded dna viruses that replicate as low copy number nuclear plasmids during the persistent phase. hpv only possess nine open reading frames but extend their coding capabilities by alternative rna splicing. we have identified in cell lines with replicating hpv31 genomes viral transcripts that connect the novel splice donor (sd) sites at nt 1426 and 1534 within the e1 replication gene to known splice acceptors at nt 3295 or 3332 within the e2/e4 reg ... | 2008 | 17904182 |
| abnormal anal cytology in high-risk human papilloma virus infection in hiv-infected australians. | to assess the prevalence of abnormal anal cytology and high-risk human papilloma virus (hpv)-type infection in hiv-infected people with a cd4 cell count >300 cells/microl. | 2008 | 17881414 |
| human papillomavirus (hpv) genotype distribution in invasive cervical cancers in france: edith study. | invasive cervical cancer (icc) remains a significant cause of morbidity and mortality in france. since human papillomavirus (hpv) is the necessary cause of icc, the aim of this study was to assess the type-specific prevalence of hpv in icc in france in order to locally evaluate the potential benefit of an hpv 16/18 l1 virus-like particles (vlp) vaccination. a total of 516 histological specimens collected in 15 centers were analyzed. among them, 86% had a diagnosis of squamous cell carcinoma (scc ... | 2008 | 17893882 |
| p53 codon 72 polymorphism and the risk of esophageal squamous cell carcinoma. | the polymorphisms of the tumor suppressor gene p53 have been extensively investigated in numerous malignant tumors, particularly carcinomas associated with human papillomavirus (hpv) infection. however, the results remain controversial. to address a potential correlation between the p53 genotypes and the risk of esophageal squamous cell carcinoma (escc), we investigated the p53 codon 72 polymorphism in 435 patients with escc and 550 cancer-free subjects from the same geographical region. p53 arg ... | 2008 | 17918207 |
| hpv e6 degradation of p53 and pdz containing substrates in an e6ap null background. | human papillomavirus (hpv) type 16 and 18 e6 proteins target many of their cellular substrates for proteasome-mediated degradation. in the case of p53, this is mediated by the e6ap ubiquitin ligase. however it is still unclear whether other e6 substrates, in particular those containing pdz domains, are also degraded in a similar manner. to investigate this, we established an epithelial cell line from e6ap-null mice and used these cells as a background to perform e6-mediated in vivo degradation a ... | 2008 | 17934525 |
| gene expression profiling to identify markers associated with deregulated htert in hpv-transformed keratinocytes and cervical cancer. | although high-risk human papillomavirus (hpv) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. one key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit htert. our previous microcell-mediated chromosome transfer studies revealed that introduction of human chromosome 6 in the hpv16-immortalized keratinocyte cell line fk16a and in the hpv16-containing cervical cancer ce ... | 2008 | 17960611 |
| cervical human papillomavirus (hpv) infection in south african women: implications for hpv screening and vaccine strategies. | the prevalence of cervical human papillomavirus (hpv) in south african women (n = 1,073) increased from 20.4% (173/848) in women with normal cytology to 41.7% (48/115) in women with atypical squamous cells of undetermined significance, 70.2% (40/57) in women with low-grade squamous intraepithelial lesions, and 83% (44/53) in women with high-grade squamous intraepithelial lesions (hsils). hpv types 16 and 35 were the dominant types in women with hsils but not in women in the other categories. | 2008 | 17977997 |
| determination of cytokine protein levels in cervical mucus samples from young women by a multiplex immunoassay method and assessment of correlates. | cytokines in cervical mucus are likely to play important roles in controlling pathogens. the cervical mucosal environment is complex, however, with many endogenous and exogenous factors that may affect cytokine levels. we used a multiplex, suspension-array-based immunoassay method to measure 10 proinflammatory (interleukin-1beta [il-1beta], il-6, and il-8) and immunoregulatory (gamma interferon [ifn-gamma], il-2, il-4, il-5, il-10, il-12, and il-13) cytokines in cervical mucus specimens collecte ... | 2008 | 17978011 |
| human papilloma virus specific t cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of hla-dq and -dp as a restriction element. | human papillomavirus (hpv)-induced malignancies are frequently infiltrated by lymphocytes. to comprehend the contribution of hpv-specific t cells in this anti-tumor response we developed a method that allowed the analysis of the presence and specificity of cervix-infiltrating and draining lymph node resident t cells in a group of 74 patients with cervical malignancies, 54 of which were induced by hpv16 or hpv18. we detected the presence of hpv16 or hpv18-specific t cells in at least 23 of the 54 ... | 2008 | 17955486 |
| e6 and e7 oncogene expression by human papilloma virus (hpv) and the aggressive behavior of recurrent laryngeal papillomatosis (rlp). | recurrent laryngeal papillomatosis (rlp), a chronic disease associated with human papilloma virus (hpv), requires serial surgical procedures for debulking, resulting in debilitating long-term dysphonia, laryngeal scarring, and rarely malignant degeneration. human papilloma virus 11 tumors have been widely accepted as more aggressive than hpv 6 tumors; however, the clinical course has been difficult to predict at disease onset, and the biologic mediators of proliferation have not been well charac ... | 2008 | 17990904 |
| epidemiology of human papillomavirus infection among fishermen along lake victoria shore in the kisumu district, kenya. | the epidemiology of human papillomavirus (hpv) infection in men in kenya is largely uncharacterized. we set out to determine the prevalence and determinants of hpv infection among sexually active fishermen along lake victoria in the kisumu district of kenya. | 2008 | 17991686 |
| oral contraceptives and clinical recurrence of human papillomavirus lesions and cervical intraepithelial neoplasia following treatment. | to evaluate the effect of oral contraceptive use on the recurrence rate of human papillomavirus (hpv) lesions and cervical intraepithelial neoplasia (cin) following ablative or excisional procedures in a long-term follow-up. | 2008 | 18001738 |
| langerhans cells and dendritic cells are cytotoxic towards hpv16 e6 and e7 expressing target cells. | dendritic cells (dc) can be cytotoxic towards tumor cells by means of tnf family molecules expressed on the cell surface of activated dcs. tumor cells expressing appropriate receptors are killed by dc, generating a source of antigen to be presented to the immune system. it has not been investigated whether langerhans cells (lc) are selectively cytotoxic to tumor cells. this is of particular interest for epithelial tumor cells that physically interact with lc in vivo. among epithelial tumors, the ... | 2008 | 18004565 |
| distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in zhejiang province, china. | various evidences reveal that the human papillomavirus (hpv) is the single most important etiologic agent in cervical carcinoma (cc). to investigate the distribution of hpv genotypes in the patients with cc and its precursors in zhejiang province, china, a total of 631 eligible samples from patients in zhejiang province with cc (n = 181), cervical intraepithelial neoplasia (cin) ii-iii (n = 345), and cin i (n = 105) were detected. age-matched samples of 217 women without cervical neoplasia were ... | 2008 | 17466048 |
| parental acceptance of human papillomavirus vaccines. | to determine whether parents would accept human papillomavirus (hpv) vaccination for their children and which variables may influence their decision, including knowledge about cervical cancer and hpv. | 2008 | 17368910 |
| high-risk human papillomavirus is present in cytologically false-negative smears: an analysis of "normal" smears preceding cin2/3. | cervical screening, currently performed by cervical cytology, depends on the timely detection of malignant lesions for its success. the presence of high-risk human papillomavirus (hrhpv) is associated with an increased risk of subsequent high-grade cervical intra-epithelial neoplasia (cin2/3) and cervical cancer. the aim of this study was to determine the extent to which hrhpv is present in cervical smears with a high a priori chance of being false negative (ie, in normal smears preceding cin2/3 ... | 2008 | 17675539 |
| p16ink4a expression, human papillomavirus, and survival in head and neck cancer. | development of head and neck cancer (hnc) is associated with human papillomavirus high-risk (hpv-hr) types. the hpv e7 oncoprotein inactivates the prb protein increasing expression of p16(ink4a). p16 expression and hpv status have been associated with differences in clinical outcomes for hnc. this study examined whether hnc prognosis was different when these biomarkers were examined as individual or joint molecular effects. tumor tissue from 301 hnc patients were analyzed and sequenced for hpv t ... | 2008 | 17360226 |
| age-specific prevalence of high-risk human papillomavirus infection in a hungarian female population with positive cytology. | patients with positive screening results and persistence of high-risk human papillomavirus (hpv) infection represent the population at the highest risk for developing cervical cancer. to describe the epidemiology in this high-risk population, data were collected and analysed at the referral centre for patients with positive cytology. | 2008 | 17714853 |
| [protection against uterine cervical cancer by hpv vaccines]. | research literature has definitively shown hpv to be a necessary cause of cervical cancer. hpv is highly prevalent in sexually active populations and its natural history is now traceable thanks to recent advances in technology. hpv-like particle can now be synthesized and assembled in vitro to constitute the major virion protein l1, and this technology has been exploited to produce hpv-l1-vlp vaccines. now, hpv-related diseases can thus be prevented by commercially available hpv prophylactic vac ... | 2008 | 19374193 |
| annual report: surveillance of adverse events following immunisation in australia, 2007. | this report summarises australian passive surveillance data for adverse events following immunisation (aefi) reported to the therapeutic goods administration for 2007, and describes reporting trends over the 8-year period 2000 to 2007. there were 1,538 aefi records for vaccines administered in 2007. this is an annual aefi reporting rate of 7.3 per 100,000 population, the highest since 2003 and an 85% increase compared with 2006 (835 aefi records; 4.0 records per 100,000 population). the increase ... | 2008 | 19374268 |
| [hpv vaccine and cervical cancer prevention in general practice. survey conducted among general practitioners in the french departments of eure-et-loir and cher]. | general practitioners are the first line to promote the human papillomavirus vaccine in teenagers and young female adults. the goal of this study is: to describe the perception, in france, of this vaccine by the general practitioners in the first 6 months after the publication of national recommendations and reimbursement of this vaccine by the social security; to know the daily practice of the cervical cancer prevention. these questions were asked through a questionnaire sent to 545 general pra ... | 2008 | 19253788 |
| a bayesian framework for estimating vaccine efficacy per infectious contact. | in vaccine studies for infectious diseases such as human immunodeficiency virus (hiv), the frequency and type of contacts between study participants and infectious sources are among the most informative risk factors, but are often not adequately adjusted for in standard analyses. such adjustment can improve the assessment of vaccine efficacy as well as the assessment of risk factors. it can be attained by modeling transmission per contact with infectious sources. however, information about conta ... | 2008 | 19169384 |
| the catch up program for human papillomavirus vaccine. | 2008 | 19149027 | |
| [epidermoid anal carcinoma]. | epidermoid carcinoma of the anus is a rare cancer, and conventionally affects elderly women. its incidence is on the increase, at a younger age of onset, particularly within the male homosexual population. main predisposing factors are sexually transmitted diseases and particularly human papillomavirus (hpv) infection, variety of sexual partners, smoking, homosexuality, history of uterine cervix cancer, and immunodepression. warning signs of anal cancer are often non-specific. therefore any atyp ... | 2008 | 19143150 |
| human papillomavirus--lessons from history and challenges for the future. | human papillomavirus (hpv) is the most common sexually transmitted infection, and hpv-associated cervical cancer is a significant cause of morbidity and mortality worldwide. recent advances in molecular biology have facilitated testing for hpv infection. over the last decade, national and international cervical cancer screening programs have added hpv testing to their guidelines. the use of hpv prophylactic and therapeutic immunization may expand the need for systematic hpv testing to help defin ... | 2008 | 19126284 |
| prevalence of human papillomavirus types 6, 11, 16 and 18 in young austrian women - baseline data of a phase iii vaccine trial. | cervical cancer is the second most common cancer among women worldwide. in the absence of changing risk or intervention, it is projected that in comparison with 2002 there will be a 40% increase in the number of new cases of cervical cancer by 2020. hpv types 16 and 18 cause 70% of cervical cancers worldwide, 50% of high-grade cervical intraepithelial neoplasias and 25% of low-grade neoplasias. hpv types 6 and 11 are the causative agent of > 90% of genital warts. the aim of this study was to ass ... | 2008 | 19116707 |
| [significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance]. | to investigate the significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance (ascus) diagnosed by cervical cytology. | 2008 | 19105350 |
| enhancement of immunotherapeutic effects of hpv16e7 on cervical cancer by fusion with ctla4 extracellular region. | cervical cancer is caused by infection by high-risk human papillomavirus (hpv), especially hpv16. limitations in current treatments of cervical cancers call for the development of new and improved immunotherapies. this study aims at investigating the efficacy of a novel vaccine consisting of modified hpv 16e7 fused with human cytotoxic t-lymphocyte antigen 4 (ctla4). the regions in hpv16 e7 gene associated with its transformation and ctl-enhanced response were modified; the resultant hpv16me7 wa ... | 2008 | 19107404 |
| implementing a school-based hpv vaccination programme. | the department of health launched a national human papillomavirus immunisation programme for girls aged 12-13 years in september 2008. | 2008 | 19090363 |
| [expression of skp2 in cervical squamous cell carcinoma and precancerous lesions and its correlation with hpv16/18 infection]. | to study the expression of skp2 in cervical squamous cell carcinoma (scc) and its precancerous lesions, and to investigate its relationship with human papillomavirus (hpv) infection. | 2008 | 19094580 |
| identification of human papillomavirus in esophageal squamous papillomas. | to investigate the presence of human papillomavirus (hpv) in esophageal squamous papilloma (esp) and determine p16, p53 and ki67 expression in a mexican cohort. | 2008 | 19084918 |
| systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy. | locally produced transforming growth factor-beta (tgf-beta) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. this article explores the potential for increased efficacy when combining immunotherapies with tgf-beta suppression using the tgf-beta type i receptor kinase inhibitor sm16. adenovirus expressing ifn-beta (ad.ifn-beta) was injected intratumorally once in established s.c. ab12 (mesothelioma) and lkr (lung cancer) tumors or intratracheally in a kras o ... | 2008 | 19074893 |
| medicines management. | 2008 | 19051531 | |
| malignancies in women with hiv infection. | women with hiv infection have an increased risk of developing certain malignancies. these malignancies are commonly human papillomavirus (hpv)-related, reflecting the high rate of coinfection with hpv in women with underlying hiv infection. these women also have a high incidence of premalignant hpv-related changes, such as high-grade squamous intraepithelial lesions as diagnosed on pap smears and cervical intraepithelial neoplasia on cervical biopsy. screening recommendations for hiv-infected wo ... | 2008 | 19072501 |
| activation of the enhancer of zeste homologue 2 gene by the human papillomavirus e7 oncoprotein. | the malignant phenotype of human papillomavirus (hpv)-positive cancer cells is maintained by the activity of the viral e6 and e7 genes. here, we identified the polycomb group gene enhancer of zeste homologue 2 (ezh2) as a novel downstream target for the viral oncogenes in hpv-transformed cells. ezh2 expression was activated by hpv16 e7 at the transcriptional level via e7-mediated release of e2f from pocket proteins. rna interference analyses showed that continuous ezh2 expression is required for ... | 2008 | 19047178 |
| oral rinses may help detect human papillomavirus-positive head, neck cancers. | 2008 | 19047664 | |
| acog practice bulletin no. 99: management of abnormal cervical cytology and histology. | recent evidence has shown that the risk of malignant and premalignant cervical disease and human papillomavirus (hpv) infections varies significantly with age (1,2). furthermore, evidence now shows that treatment for cervical disease carries significant risk for future pregnancies (3-7). these factors have led to a re-evaluation of the guidelines for the management of premalignant cervical disease. the purpose of this document is to define strategies for diagnosis and management of abnormal cerv ... | 2008 | 19037054 |
| gene expression profile of cervical and skin tissues from human papillomavirus type 16 e6 transgenic mice. | although k14e6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. these findings suggest that e6 performs critical functions in normal adult cervix and skin, highlighting the need to define e6-controlled transcriptional programs in these tissues. | 2008 | 19036130 |
| human papillomavirus vaccine: are the concerns unfounded? | 2008 | 18997145 | |
| [construction of recombinant vaccinia virus expressing hpv18e7e6 fusion proteins and detection of its immunogenicity in mice]. | to construct one recombinant vaccinia virus expressing the hpv18 e6 and e7 fusion proteins as hpv18 therapeutic vaccine candidate, and test its immunogenicity. | 2008 | 19031699 |
| [laryngeal papillomatosis: etiology, diagnostics and therapy]. | papillomas are rare tumors that originate from the mucosa. they may appear in the nose, paranasal sinuses, oral cavity, larynx, trachea, or the skin. papillomas are mainly asymptomatic and are therefore mostly diagnosed coincidentally. in contrast, laryngeal papillomatosis may cause stridor, dyspnoea, and hoarseness. a viral cause of the disease seems likely, especially human papilloma virus. mechanical irritation is also a possible reason when the nose, oral cavity, or oropharynx is affected. a ... | 2008 | 19034400 |
| prevention of cervical cancer. | this article reviews the burden of cervical cancer in south africa and shows that it remains the most common cancer among south african women, particularly women with least access to cervical cancer screening. it explains the rationale behind the south african cervical cancer screening policy, which is to offer all asymptomatic women three free cervical smears in a lifetime, beginning at age 30, 10 years apart. further, it illustrates that cervical cancer screening offers unique opportunities fo ... | 2008 | 19027619 |
| human papillomavirus vaccination in the united kingdom: what about boys? | in september 2008 the uk department of health initiated a human papillomavirus (hpv) immunisation programme for girls aged 12-13 for prevention of cervical cancer, which is most often caused by two hpv types. an important question, yet to be addressed, is whether boys should also be vaccinated. men also get hpv and transmit it sexually, not just women. certain hpv types are associated with genital warts, which have significant morbidity, and with difficult to treat non-cervical malignancies, inc ... | 2008 | 19027627 |
| viral vaccines for dermatologic disease: some additional information regarding hpv and hsv. | 2008 | 19022110 | |
| alaska native parental attitudes on cervical cancer, hpv and the hpv vaccine. | to describe alaska native parents' knowledge of and attitudes towards cervical cancer, the human papillomavirus (hpv) and the hpv vaccine. | 2008 | 19024805 |
| expression of the p16 and ki-67 in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection. | the purposes of this study were to evaluate the expression of p16(ink4a) (referred as to p16) and ki-67 in cervical intraepithelial neoplasia (cin), and the correlation between high-risk human papillomavirus (hpv) infection and the above biomarkers. | 2008 | 19471565 |
| human papillomavirus vaccines: why the time is right to implement immunization and surveillance programs in canada. | 2008 | 19436510 | |
| expression of p16 in conjunctival intraepithelial neoplasia does not correlate with hpv-infection. | the aim of our study was to identify the frequency of expression of p16(ink4a) (cdkn2a) and hpv (human papilloma virus) in different grades of conjunctival intraepithelial neoplasia (cin).twelve specimens including cin i (2), ii (3), iii (5), and cin with beginning invasion (2), as well as 15 control specimens, were stained with antibodies against p16(ink4a) and mib1. the presence of hpv was examined by pcr.p16 as well as mib1 were significantly elevated in cin compared to control specimens (p<0 ... | 2008 | 19516893 |
| human papillomavirus frequency in oral and oropharyngeal cancer in greece. | the presence of human papillomavirus (hpv) was successfully analyzed by both general and type-specific hpv pcr in 103 samples from 115 patients diagnosed with oral and oropharyngeal cancer in greece during the years 1986-2007. results: in total 13/103 (13%) tumours were hpv-positive and the majority of these were hpv-16-positive. of the tonsillar cancer samples, 12/28 (43%) were hpv-positive and, notably, 1/6 (17%) collected between 1992-1998 and 11/22 (50%) collected between 2000-2007 were hpv- ... | 2008 | 18751378 |
| [vaccine against human papilloma virus]. | genital human papilloma virus infection (hpv) is the most common sexually transmitted infection worldwide, it is the cause of genital warts, and it is related with cervical cancer, the second most common cause of death from cancer in women in america, and the first in underdeveloped countries, and it is related with penis and prostate cancer in males also, and with anal cancer in both genders. this review examines the most important actual facts about hpv infection, and the new prophylactic vacc ... | 2008 | 19263667 |
| risk factors & screening modalities for oral cancer. | dentists are at the forefront for screening oral cancer. in addition to the well known carcinogenic potential of tobacco and alcohol, betel nut chewing and human papilloma virus are important risk factors in the development of oral cancer. to aid in screening and decreasing morbidity and mortality from oral cancer, a variety of techniques have been developed. these techniques show promise but they require additional investigations to determine their usefulness in oral cancer detection. dentists ... | 2008 | 19388239 |
| computational prediction of nuclear localization signals and structural characteristics of 91 types of hpv e6 proteins. | human papillomaviruses (hpvs) are small dna tumor viruses that replicate and assemble exclusively in the nucleus. thus their proteins, including e6, must carry nuclear localization signals (nlss) to enter the nucleus. to analyze and to predict the nuclear localization signals and several post translational modifications by bioinformatics analysis, we obtained 91 e6 protein sequences from available databases. to investigate the localization of these sequences, we used hum-ploc software. homology ... | 2008 | 19256751 |