Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| effects of d,l-propranolol on apomorphine induced stereotyped behavior in rats. | the effects of d,l propranolol on stereotyped behavior induced by apomorphine administration was studied quantitatively. d,l propranolol caused a 2.5 leftward displacement of the control dose-response curve constructed to apomorphine-induced stereotypy; the ed50 for apomorphine was reduced from 1.87 +/- 0.38 to 0.74 +/- 0.17. the potentiation was dependent on both d,l-propranolol and apomorphine doses. results are discussed in the light of a possible interference of the central noradrenergic sys ... | 1987 | 3569842 |
| enterotoxicity of el tor-like hemolysin of non-o1 vibrio cholerae. | the enterotoxicity of an el tor-like hemolysin purified from non-o1 vibrio cholerae was investigated. fluid accumulation was induced by injection of purified hemolysin into the ligated intestinal loops in adult rabbits (de test), intraintestinal administration in infant rabbits (dutta test), and oral inoculation in suckling mice. the accumulated fluid was invariably mucous and bloody, and a histological change in the mucosa was observed. these results suggest that the hemolysin is an enterotoxic ... | 1987 | 3570456 |
| transcription of cholera toxin operon in wild-type and mutant strains of vibrio cholerae. | mrna for cholera toxin (ct) was measured in wild-type, hypertoxinogenic, and hypotoxinogenic strains of the classical biotype. the amount of ct-specific mrna was directly related to the amount of ct that the strains could produce. estimates of the size of the mrna for ct in individual experiments varied between approximately 900 and 1,100 nucleotides. | 1987 | 3570476 |
| observations on the binding of lanthanides and calcium to vitamin d-dependent chick intestinal calcium-binding protein. implications regarding calcium-binding protein function. | the binding of calcium and terbium to purified chick vitamin d-dependent intestinal calcium-binding protein was studied by terbium fluorescence, circular dichroism, and intrinsic protein fluorescence techniques. calcium-binding protein bound, with high affinity, at least 3 mol of terbium/mol of protein; numerous low affinity terbium-binding sites were also noted. the three highest affinity sites were resolved into one very high affinity site (site a) and two other sites (sites b and c) with slig ... | 1987 | 3571269 |
| transcriptional behavior of silkmoth chorion genes in vivo and in injected xenopus laevis oocytes. | a cloned fragment of bombyx mori genomic dna containing a pair of chorion genes was injected into xenopus laevis oocytes. the rna transcribed from the injected template was examined by primer extension analysis for the presence of transcripts initiated correctly from the two chorion genes. using as primers a number of fragments derived from various parts of the injected dna, we have found that transcription initiation around the cap sites of the chorion genes was considerably more frequent than ... | 1987 | 3571273 |
| neuronal inhibition of astroglial cell proliferation is membrane mediated. | previously we have used a microwell tissue culture assay to show that early postnatal mouse cerebellar astroglia have a flattened morphology and proliferate rapidly when they are cultured in the absence of neurons, but develop specific cell-cell contacts and undergo morphological differentiation when they are co-cultured with purified granule neurons (hatten, m. e., 1985, j. cell biol., 100:384-396). in these studies of cell binding between neurons and astroglia, measurement with light and fluor ... | 1987 | 3571332 |
| involvement of gastrointestinal mechano- and intestinal chemoreceptors in vagal reflexes: an electrophysiological study. | the role of gastrointestinal mechanoreceptors and intestinal chemoreceptors in the genesis of vago-vagal reflexes was assessed by recording single vagal efferent fibre discharge in the urethane-anaesthetized ferret during procedures known to activate discrete populations of gastrointestinal afferent fibres. distension of the stomach, duodenum and jejunum was used to activate mechanoreceptors while perfusion of the intestinal loops with various chemical solutions was used to activate mucosal chem ... | 1987 | 3571829 |
| summary of the 22nd united states-japan joint cholera conference. | 1987 | 3572049 | |
| deacylated lipopolysaccharide inhibits neutrophil adherence to endothelium induced by lipopolysaccharide in vitro. | selective deacylation of the nonhydroxylated fatty acids from s. typhimurium lps by an acyloxyacyl hydrolase isolated from leukocytes reduces toxic activity of lps in vivo. we examined the effect of deacylated lps on neutrophil adherence to human umbilical vein endothelial cells (huve). pretreatment of huve with lps (13 ng/ml for 4 h) produced a marked increase in the adherence of subsequently added neutrophils. in contrast, there was no increase in the adherence of neutrophils to huve pretreate ... | 1987 | 3572302 |
| deacylated lipopolysaccharide inhibits neutrophil adherence to endothelium induced by lipopolysaccharide in vitro. | selective deacylation of the nonhydroxylated fatty acids from s. typhimurium lps by an acyloxyacyl hydrolase isolated from leukocytes reduces toxic activity of lps in vivo. we examined the effect of deacylated lps on neutrophil adherence to human umbilical vein endothelial cells (huve). pretreatment of huve with lps (13 ng/ml for 4 h) produced a marked increase in the adherence of subsequently added neutrophils. in contrast, there was no increase in the adherence of neutrophils to huve pretreate ... | 1987 | 3572302 |
| characterization of vibrio eltor typing phages: properties of the eltor phage e4. | biophysical characteristics of vibrio eltor phage e4, a key phage in the vibrio cholerae typing scheme were studied. this icosahedral phage was found to contain 12 structural polypeptides with mol. wt. ranging from 25,000 to 120,000. one of these polypeptides of mol. wt. 50,000 accounted for most of the structural proteins present and was probably the major phage capsid protein. the phage genome comprised a single linear, double-stranded dna molecule, 69.2 kbp in length (45.6 x 10(6) mol. wt.) a ... | 1987 | 3572368 |
| pulmonary effects due to short-term exposure to oil fog. | rats were exposed to an oil fog generated by flash vaporation and subsequent condensation of lightweight lubricating oil. exposures were for 3.5 h/d, 4 d/wk, for 4 wk, at concentrations of 1.5, 0.5, or 0.0 mg/l and a particle size of approximately 1 micron. samples of respiratory tissues were taken for histopathologic analyses, lavage fluid samples were collected, and pulmonary function measurements were made the day after the last exposure. an accumulation of macrophages within the alveolar lum ... | 1987 | 3573069 |
| inhibition of reovirus type 3 binding to host cells by sialylated glycoproteins is mediated through the viral attachment protein. | the interaction of mammalian reoviruses with sialylated glycoproteins was studied and found to be highly serotype specific in that attachment of type 3 dearing reovirus to murine l cell receptors could be strongly inhibited by bovine submaxillary mucin (bsm), fetuin, and alpha 1 acid glycoprotein, albeit at different efficiencies, whereas attachment of type 1 lang reovirus was inhibited only by fetuin. we subsequently demonstrated, by using reassortants between type 3 and 1 reoviruses, that inhi ... | 1987 | 3573143 |
| reduction in atherosclerosis in swine by cod-liver oil. | 1987 | 3574390 | |
| intracellular distribution of molecular forms of acetylcholinesterase in rat brain and changes after diisopropylfluorophosphate treatment. | the subcellular distribution of acetylcholinesterase activities was studied in the striatum and cerebellum of rat brain. the highest percentage of the enzyme activity was found in the crude synaptosomal (p2) fraction, with striatum much higher than cerebellum. on sucrose density gradient centrifugation analyses all the particulate fractions (p1, p2, and p3) showed a major peak of the 10 s form of acetylcholinesterase activity with very little activity of the 4 s form of the enzyme. the 10 s/4 ra ... | 1987 | 3574585 |
| inhibition of equine neutrophil chemotaxis and chemokinesis by a taenia taeniaeformis proteinase inhibitor, taeniaestatin. | taeniaestatin, a recently isolated taenia taeniaeformis proteinase inhibitor, was used to inhibit equine neutrophil migration. taeniaestatin itself was not chemotactic when used as a chemotactic factor but taeniaestatin did inhibit neutrophil chemokinesis when tested in a zigmond-hirsch checkerboard assay. a dose-dependent inhibition of both chemokinesis and chemotaxis was observed when zymosan activated bovine sera (zabs) was used as the chemotactic factor. this inhibition was greater than 95% ... | 1987 | 3574975 |
| growth-associated traits in parental and f1 populations of chickens under different feeding programs. 3. eating behavior and body temperatures. | in two experiments, parental populations of chickens and their f1 crosses were fed ad libitum or on alternate days. eating and drinking behaviors, ability to compensate for fasting, and surface and cloacal temperatures were measured. genetic and environmental (due to fasting) differences in feeding and drinking behaviors were found. chicks from lines selected for larger body weight were better able to compensate for a 24-hr fast than those selected for smaller weight. crosses were similar to the ... | 1987 | 3575234 |
| maternal aggression towards different sized male opponents: effect of chlordiazepoxide treatment of the mothers and d-amphetamine treatment of the intruders. | lactating female rats vigorously attack equally sized conspecific males introduced into their home cage. under conditions of such high aggression, the previously reported pro-aggressive action of a low (5 mg/kg) dosage of chlordiazepoxide (cdp) is hardly detectable. when opponents are large, the intensity of the aggression is less than what is seen with small ones. in this situation treatment of the females with cdp increases aggression levels substantially. the importance of intruders evoking a ... | 1987 | 3575374 |
| urinary anti diuretic hormone level in essential hypertension. | the present study was aimed to examine the excretory urinary anti diuretic hormone (adh) pattern in five normotensive and ten hypertensive human subjects. it was observed that essential hypertensive subjects excreted higher urinary adh 8.03 +/- 1.17 mu/hr as compared to 3.60 +/- 0.72 mu/hr the difference between the two groups being statistically significant (p less than 0.01). various renal function parameters evaluated were within normal limits. the results of this study suggest the involvemen ... | 1987 | 3575383 |
| auditory elicitation of the p300 event-related evoked potential in the rat. | auditory stimuli were used to elicit a p300 event-related evoked potential (erp) in rat. test conditions were comparable to those for eliciting erp's in humans. a train of background tones with a randomly inserted target tone at a ten to one ratio were presented individually to ten unrestrained subjects in a baseline, a novel, and a trained condition. in the novel condition eeg's were averaged from subjects hearing both background and target stimuli for the first time. in the trained condition, ... | 1987 | 3575494 |
| cardiac xenotransplantation in primates. | successful cardiac xenotransplantation would alleviate the severe shortage of donor organs that presently limits the availability of cardiac transplantation. early attempts at human xenotransplantation achieved minimal success. however, the effectiveness of cyclosporine in nonhuman xenotransplant models has received little experimental investigation. we have therefore studied the effect of cyclosporine-based immunosuppression in primate cardiac xenograft models using cynomolgus monkey donors and ... | 1987 | 3553747 |
| rearrangement and expression of erythropoietin genes in transformed mouse cells. | the erythroleukemia cell line iw32, derived by transformation with the friend murine leukemia virus, has been shown previously to produce erythropoietin (epo) constitutively. here we demonstrate that, in addition to the normal mouse epo locus, this cell line has another epo locus which has undergone rearrangement and amplification. both loci were cloned, and the rearrangement breakpoint of the second epo locus was located within a 1.1-kilobase region upstream of an otherwise apparently normal ep ... | 1987 | 3561395 |
| reconstitution of mucosal mast cells in w/wv mice by adoptive transfer of bone marrow-derived cultured mast cells and its effects on the protective capacity to strongyloides ratti-infection. | bone marrow-derived cultured mast cells (bmmc) were transferred intravenously into w/wv mice to examine if they could reconstitute defective mucosal mast cell response or defective protective capacity against infection with strongyloides ratti. when mast cell growth factor-producing activity of w/wv mice were examined, mesenteric lymph node cells obtained at 7 to 14 days after infection could produce this factor in vitro by stimulation with s. ratti-adult worm antigen. a single injection of bmmc ... | 1987 | 3562059 |
| reconstitution of mucosal mast cells in w/wv mice by adoptive transfer of bone marrow-derived cultured mast cells and its effects on the protective capacity to strongyloides ratti-infection. | bone marrow-derived cultured mast cells (bmmc) were transferred intravenously into w/wv mice to examine if they could reconstitute defective mucosal mast cell response or defective protective capacity against infection with strongyloides ratti. when mast cell growth factor-producing activity of w/wv mice were examined, mesenteric lymph node cells obtained at 7 to 14 days after infection could produce this factor in vitro by stimulation with s. ratti-adult worm antigen. a single injection of bmmc ... | 1987 | 3562059 |
| [lecithinase activity of vibrio cholerae and of vibrios not agglutinated by o-cholera serum]. | the lecithinase activities of 187 v. cholerae strains differing in their virulence and 70 cultures of nag vibrios of different origin varied in all experimental groups. the level of lecithinase activity in the groups of v. cholerae strains having low virulence, or no virulence at all, was considerably higher than in virulent strains. nag vibrios isolated from diarrhea patients and from samples of lake and pond water did not differ in the activity of this enzyme. | 1987 | 3577496 |
| dimensions of the horizontal semicircular duct, ampulla and utricle in the human. | this study provides measurements in individual specimens of the sizes, cross-sectional shapes and areas all around the path of fluid flow through the human horizontal semicircular duct, ampulla and utricle. these data were obtained from multiple measurements on individual specimens which had been fixed by immersion in karnovsky's fixative and microdissected. the results are compared with similar measurements in the rat and guinea pig. | 1987 | 3577757 |
| trace elements in human health with special reference to selenium. | 1987 | 3578121 | |
| trace elements in human health with special reference to selenium. | 1987 | 3578121 | |
| ingestive behavior of rats with ibotenic acid lesions of the dorsomedial hypothalamus. | rats with electrolytic or kainic acid (ka) lesions of the dorsomedial hypothalamic nucleus area (dmha-l) are hypophagic, hypodipsic, and have a reduced body weight (bw) compared with controls. in the present study, male sprague-dawley rats received bilateral ibotenic acid (ibo) lesions of the dmha (3 micrograms in 0.3 microliter) or sham (s) operations. during the next 32 days the ibo dmha-l rats showed reduced (p less than 0.01) food and water intake, bw, and linear growth (p less than 0.03), a ... | 1987 | 3578558 |
| ingestive behavior of rats with ibotenic acid lesions of the dorsomedial hypothalamus. | rats with electrolytic or kainic acid (ka) lesions of the dorsomedial hypothalamic nucleus area (dmha-l) are hypophagic, hypodipsic, and have a reduced body weight (bw) compared with controls. in the present study, male sprague-dawley rats received bilateral ibotenic acid (ibo) lesions of the dmha (3 micrograms in 0.3 microliter) or sham (s) operations. during the next 32 days the ibo dmha-l rats showed reduced (p less than 0.01) food and water intake, bw, and linear growth (p less than 0.03), a ... | 1987 | 3578558 |
| effects of chitin and its soluble derivatives on survival of vibrio cholerae o1 at low temperature. | chitin concentrations greater than 0.04% (wt/wt) protected cholera vibrios against killing at low temperature. this protective effect was detected with both the soluble form of chitin, glycol chitin, and the insoluble particulate form of chitin. some amino acids or peptides also showed the same protective effect. | 1987 | 3579274 |
| fatal infectious mononucleosis and virus-associated hemophagocytic syndrome. | a detailed clinicopathologic analysis of 52 cases of fatal infectious mononucleosis was performed. fever, rash, generalized lymphadenopathy, hepatosplenomegaly, and blood cytopenias were the characteristic findings. epstein-barr virus infection was documented in 44 of the 52 patients. a triphasic process evolved in the blood and bone marrow of 43 patients. early, the leukocyte count was elevated due to numerous atypical lymphoid cells, and the marrow was hyperplastic. later, severe pancytopenia ... | 1987 | 3579509 |
| four cases of neoplasia in captive wild birds. | four cases of malignant neoplasia in captive wild birds are described: an adenocarcinoma of the adrenal gland in a mountain duck (tadorna tadornoides), a malignant melanoma in the thoracic cavity of a combed duck (sarkidiornis melanotos), a hepatocellular carcinoma with pulmonary metastasis in an asian purple swamphen (porphyrio porphyrio), and an undifferentiated carcinoma in the abdomen with metastasis to skeletal muscle in a white-breasted waterhen (amaurornis phoenicurus). the tumors were di ... | 1987 | 3579789 |
| the effect of sodium phenytoin on central nervous system oxygen toxicity. | the effect of sodium phenytoin on hyperbaric oxygen (hbo) induced central nervous system (cns) toxicity was studied in rats. the latency of the epileptic electroencephalographic discharges was measured in 20 phenytoin-treated rats exposed to 6 ata of 100% oxygen, and compared with that of 20 saline-injected rats exposed to the same pressure of pure oxygen. no statistically significant difference was found in the latency between the two groups. in addition, phenytoin failed to suppress or to modi ... | 1987 | 3579804 |
| physiologic and biochemical effects of immobilization on muscle. | muscle strength rapidly declines during limb immobilization because of a decrease in muscle size and a decrease in tension per unit of muscle cross-sectional area. muscle fatigability also increases rapidly after limb immobilization. muscles within limbs fixed by plaster casts have lower levels of resting glycogen and adenosine triphosphate (atp), a more rapid depletion of muscle glycogen and atp during work, a greater increase in lactate during work, and a decreased capacity to oxidize fatty ac ... | 1987 | 3581565 |
| [modulating effect of immunotherapy with modified tumor cells in transplantable lymphoma]. | vibrio cholerici neuraminidase was studied on cba mice for its effect on the strain nk/ly lymphoid cells oncogenicity in intraabdominal transplantation. the 30% decrease in transplantability of cells treated by the enzyme in the dose of 50 u/ml was established. the modulating effect of specific active immunotherapy by modified cells in lymphoma was also studied. a pronounced stimulation of immunity t-cell links and proliferation in immunocompetent organs, an increase in the number of large granu ... | 1987 | 3582237 |
| adrenal gland denervation and diving in ducks. | the extreme elevation in plasma levels of free norepinephrine (ne) and free epinephrine (ep), which occurs during forced diving of ducks (anas platyrhynchos), was studied before and after denervation of the adrenal glands. in intact animals both ne and ep concentration increased by up to two orders of magnitude in a 4-min dive but by a significantly lesser amount if the duck breathed o2 before the dive. denervating the adrenal glands reduced the amounts of both catecholamines (ca) released durin ... | 1987 | 3591985 |
| pulsatile release of antipyretic neuropeptide alpha-msh from septum of rabbit during fever. | the effects on fever of central administration of alpha-melanocyte-stimulating hormone (alpha-msh) and its antiserum, the specific increase in central concentration of alpha-msh during fever, and related results indicate that this neuropeptide is important to central nervous system (cns) regulation of the febrile response. the present experiments were designed to establish whether alpha-msh is released from septal tissue during fever and, if so, in what temporal course relative to the febrile re ... | 1987 | 3591986 |
| laser influence on the rate of degeneration of damaged nerves. | the sciatic nerves were sectioned and sutured back. the rate of degeneration at the point of suture was studied. laser treatment increased the rate of degeneration of the damaged fibers. | 1987 | 3592253 |
| technique for measuring the area of canine articular surfaces. | a method for measuring the surface area of canine articular cartilage was developed. ten pairs of humeri were harvested from fresh canine cadavers. the articular cartilage of each humeral head was covered with liquid rubber latex applied with a brush to the margins of the articular surface. the latex cast was removed from the cartilage after the latex dried. radial cuts were made in the cast so it could be flattened into a 2-dimensional plane. the surface area of each cast was then measured, usi ... | 1987 | 3592358 |
| storage conditions and stability of thyrotropin and thyroid hormones on filter paper. | we evaluated the effects of temperature and humidity on thyroid hormones (t4, t3) and thyrotropin (tsh) measured in blood spots dried on filter paper. rias for t4 and t3 blood spots were optimized to measure these analytes over the neonatal and euthyroid adult reference intervals. sensitivities of the t3 and t4 assays were 0.5 and 10 nmol/l, respectively. a blood-spot immunoradiometric assay for tsh involving magnetizable particles was developed with a sensitivity of 6 milli-int. units/l. contro ... | 1987 | 3594835 |
| storage conditions and stability of thyrotropin and thyroid hormones on filter paper. | we evaluated the effects of temperature and humidity on thyroid hormones (t4, t3) and thyrotropin (tsh) measured in blood spots dried on filter paper. rias for t4 and t3 blood spots were optimized to measure these analytes over the neonatal and euthyroid adult reference intervals. sensitivities of the t3 and t4 assays were 0.5 and 10 nmol/l, respectively. a blood-spot immunoradiometric assay for tsh involving magnetizable particles was developed with a sensitivity of 6 milli-int. units/l. contro ... | 1987 | 3594835 |
| the use of ground reaction measuring shoes in gait evaluation. | ground reaction force is one of the most relevant parameters in the assessment of human gait. it is, however, difficult to measure without encumbering natural locomotion. a description of a system for measuring the vertical component of the ground reaction force and its distribution under the foot is given. the calibration procedure for the measuring shoes is described. the results of measurements are compared with those obtained from a force plate. illustrative examples of the changes in pathol ... | 1987 | 3595081 |
| [effect of molybdenum mo on the alkylation of dna in the liver of rats treated with 14c-diethylnitrosamine]. | effect of molybdenum on the alkylation of dna in the liver of rats treated with 14c-diethylnitrosamine was studied. when administered orally at a dose of 1 mg/rat/day as (hn4)6 mo7o24 for 30 days, mo inhibited the alkylation of dna in the liver of rats. the level of 3-ethylguanine, n7-ethylguanine and o6-ethylguanine decreased. simultaneously, the exhalation of 14co2 and the urinary excretion of 14c- were increased as compared to the controls. at a dose of 5 mg/rat/day, mo increased the alkylati ... | 1987 | 3595421 |
| differential transcription of the repetitive r-element in various mouse cell types. | clones that contain r-elements separated from the rest of the l1-repeat have been isolated from a mouse genomic dna library. spot hybridization of dna from various species (from mammals to plants) with one representative and well characterized mouse dna clone shows that at least this sequence hybridizes only with mouse dna. in addition, we demonstrate that the r-element repeat is transcribed differentially in various tissues or cell types. furthermore, the amount of r-transcripts is regulated at ... | 1987 | 3596249 |
| [use of behavioral studies in hygienic studies of plant growth regulators]. | 1987 | 3596284 | |
| changes in hemodynamics and myocardial contractility during chronic sodium depletion in conscious dogs. | chronic sodium depletion has been reported to decrease ejection fraction in anesthetized dogs. we tested the hypothesis that this reduction in cardiac performance is due to either hemodynamic or humoral factors. seven mongrel dogs were fed a low sodium diet (less than 2 meq na+ per day) for 5 weeks. echocardiographic and radionuclide techniques were used to monitor cardiac function. there was a gradual but significant (p less than 0.01) decrease in ejection fraction from 61 +/- 7% (sd) at baseli ... | 1987 | 3596785 |
| fibre types in extraocular muscles: a new myosin isoform in the fast fibres. | we report on the existence of a myosin heavy chain (mhc) isoform with unique structural properties in extraocular (eo) muscles. differences in mhc composition are apparent using a polyclonal antibody prepared against myosin isolated from bovine eo muscle myosin. in enzyme immunoassays and western blotting experiments, this anti-eo myosin antibody reacted specifically with the heavy chains of eo muscle myosin and not with the heavy chains of other myosins. the distribution of this new mhc isoform ... | 1987 | 3597767 |
| fibre types in extraocular muscles: a new myosin isoform in the fast fibres. | we report on the existence of a myosin heavy chain (mhc) isoform with unique structural properties in extraocular (eo) muscles. differences in mhc composition are apparent using a polyclonal antibody prepared against myosin isolated from bovine eo muscle myosin. in enzyme immunoassays and western blotting experiments, this anti-eo myosin antibody reacted specifically with the heavy chains of eo muscle myosin and not with the heavy chains of other myosins. the distribution of this new mhc isoform ... | 1987 | 3597767 |
| immunizations among hospital personnel. | to minimize the likelihood of transmission of certain infectious diseases within the hospital, the 5 million us health care personnel are becoming a special target group for immunization programs. a review of immunizations conducted by a hospital employee health service demonstrated that 80% of hospital employees are adequately protected against tetanus/diphtheria, and 97% are immune to rubella. in contrast, only 28% of at-risk employees are immunized against hepatitis b and only 2% are immunize ... | 1987 | 3598735 |
| soluble lactose-binding lectins from chicken and rat. | 1987 | 3600343 | |
| translational control mediated by eucaryotic initiation factor-2 is restricted to specific mrnas in transfected cells. | the translational efficiency of mrna molecules transcribed from plasmid dna transfected into cos-1 monkey cells can be increased 10- to 20-fold by the coexpression of the adenovirus virus-associated rnas i and ii. experiments described here demonstrate a similar increase in translational efficiency by the addition of 2-aminopurine, an inhibitor of double-stranded rna-activated protein kinase, to the culture medium. both virus-associated rna and 2-aminopurine presumably exert their effect by alte ... | 1987 | 3600637 |
| [sexually transmitted diseases: chlamydia trachomatis]. | 1987 | 3601200 | |
| plasma thyroxine and cortisol under basal conditions and during cold stress in the aging dog. | the effects of aging on plasma concentration of thyroxine (t4) and cortisol and on responses of these hormones to low ambient temperatures were determined in the dog. female beagle dogs were divided into three age groups: old, adult, and puppies. the mean (+/- sd) ages were 11.4 +/- 0.2 years, 3.0 +/- 0.4 years, and 7.6 +/- 0.2 weeks, respectively. all dogs came from a genetically homogeneous colony and were free from any disease. the adult and old dogs were used during anestrus. based on four d ... | 1987 | 3601949 |
| plasma thyroxine and cortisol under basal conditions and during cold stress in the aging dog. | the effects of aging on plasma concentration of thyroxine (t4) and cortisol and on responses of these hormones to low ambient temperatures were determined in the dog. female beagle dogs were divided into three age groups: old, adult, and puppies. the mean (+/- sd) ages were 11.4 +/- 0.2 years, 3.0 +/- 0.4 years, and 7.6 +/- 0.2 weeks, respectively. all dogs came from a genetically homogeneous colony and were free from any disease. the adult and old dogs were used during anestrus. based on four d ... | 1987 | 3601949 |
| development of physical dependence on midazolam by oral self-administration. | groups of rats drank either a solution of the ultrashort-acting benzodiazepine midazolam or water under schedule-induced polydipsia conditions in chronic, daily, 3-hr sessions. in experiment 1, the physical dependence status of animals was tested after 9 months by the precipitated withdrawal method using the benzodiazepine-blocking agent ro 15-1788 and by exposure to a brief audio stimulus at 1.5, 12 and 24 hr following drug withdrawal. ro 15-1788 failed to produce withdrawal signs, while the au ... | 1987 | 3602036 |
| breast-feeding children in the household as a risk factor for cholera in rural bangladesh: an hypothesis. | vibrio cholerae 01 produces symptomatic and asymptomatic infections. in this study, we investigated a cholera epidemic in northern bangladesh to specifically search for risks of developing symptomatic infection. a case-control study in six villages found that cases were more likely than controls to have in their family a child who was still breast-feeding and who had been asymptomatic during the epidemic. among 24 case-control pairs with cholera-like diarrhea as cases, there were 11 discordant f ... | 1987 | 3603697 |
| regulation of drinking and vasopressin secretion: role of organum vasculosum laminae terminalis. | we have proposed that the organum vasculosum laminae terminalis (ovlt) contains osmoreceptors involved in the regulation of drinking and secretion of arginine vasopressin (avp) in the dog. by use of the technique of electrolytic ablation, conscious dogs were evaluated for their responses to acute peripheral challenges of hypertonic nacl and angiotensin ii (ang ii) and hemorrhage (20 ml/kg) before and after destruction of the ovlt (n = 7) or adjacent tissue (n = 9) as a control. lesions confined ... | 1987 | 3605376 |
| elevated temperature method for recovery of vibrio cholerae from oysters (crassostrea gigas). | of 222 vibrio cholerae isolates from diverse clinical and environmental sources, 219 produced visible growth in alkaline peptone broth when incubated overnight at 42 degrees c. in field trials conducted to compare enrichment at incubation temperatures of 42 and 35 degrees c, significantly higher rates of isolation (p less than 0.05) and recovery (p less than 0.01) of v. cholerae from oysters were observed at 42 degrees c. | 1987 | 3606095 |
| evaluation of the multitest medium for rapid presumptive identification of vibrio cholerae from environmental sources. | the multitest v. cholerae medium (vc medium) for rapid presumptive identification of vibrio cholerae was evaluated. on the basis of reactions in the vc medium, 379 strains recovered during a yearlong ecological study in calcutta were presumptively identified as v. cholerae. further phenotypic characterization of these strains revealed that the reactions of 371 (97.9%) isolates were consistent with that of v. cholerae. false-positive reactions were exhibited by eight (2.1%) strains, three of whic ... | 1987 | 3606096 |
| incidence of vibrio cholerae from estuaries of the united states west coast. | the incidence of vibrio cholerae in shellfish, sediment, and waters of california, oregon, and washington was determined during the summer of 1984. samples from 24 distinct estuaries were analyzed qualitatively. v. cholerae non-o1 was found in 23 estuaries and in 44.6% of the 529 samples examined. v. cholerae o1 inaba was isolated from water samples in morro bay, calif. vibrio mimicus was found in 2.3% of the samples. cholera enterotoxin was not found in cell-free filtrates of the 100 isolates t ... | 1987 | 3606111 |
| plasmid-mediated trimethoprim-resistance in staphylococcus aureus. characterization of the first gram-positive plasmid dihydrofolate reductase (type s1). | the trimethoprim-resistance gene located on plasmid psk1, originally identified in a multi-resistant staphylococcus aureus from australia, encodes the production of a dihydrofolate reductase (type s1), which confers a high degree of resistance to its host and is quite unlike any plasmid-encoded dihydrofolate reductase hitherto described. it has a low mr (19,700) and has a higher specific activity than the constitutive gram-negative plasmid dihydrofolate reductases. the type s1 enzyme is heat-sta ... | 1987 | 3606580 |
| [assay of thermolabile enterotoxins of escherichia coli and vibrio cholerae by inhibition of erythroadsorption on the gm1 ganglioside]. | a gm1 erythroassay (gerydo) for heat-labile escherichia coli enterotoxin (lt) and cholera toxin (ct) is described. this assay was developed for use in poorly equipped laboratories in developing countries. it uses gm1-coated polystyrene plates and is based on the competition between the toxin to be assayed and ct covalently bound to sheep red blood cells. gerydo can detect 0.9 or 0.5 ng of ct per ml depending on the method of sensitization of erythrocytes. good quantitative and qualitative correl ... | 1987 | 3606879 |
| analysis of antigen involved in circulating immune complexes in patients with idiopathic thrombocytopenic purpura. | circulating immune complexes (cic) were frequently observed in patients with idiopathic thrombocytopenic purpura (itp). to analyse the pathogenic role of cic, we studied the correlation between the disease activity and the cic level, and whether platelet antigens were involved in cic from itp sera. elevated cic levels, measured by clq, anti-c3 and spermatozoa micro-enzyme-linked immunosorbent assay, were found in 37%, 54% and 52% of the patients, respectively. however, there were no significant ... | 1987 | 3608226 |
| effect of protein-modifying reagents on water-soluble and membrane bound ovarian lh/hcg receptor. | preincubation of corpora lutea membrane and follicular fluid water-soluble receptor with protein-modifying reagents suggests that sulfhydryl, histidyl and tyrosyl groups are involved in the interaction of hcg with the receptor. | 1987 | 3609166 |
| serological studies of british leptospiral isolates of the sejroe serogroup. iii. the distribution of leptospires of the sejroe serogroup in the british isles. | some 94 strains of leptospires belonging to the sejroe serogroup isolated in the british isles were identified to the serovar level using specific factor sera. seventy strains were identified as leptospira interrogans serovar hardjo, 66 from cattle, 2 from pigs and 1 each from a sheep foetus and a human. twenty-four strains were identified as l. interrogans serovar saxkoebing, most strains were isolated from either wood mice, bank or field voles but strains were also isolated from badgers, a fox ... | 1987 | 3609169 |
| expression of "retinal" contrast gain control by neurons of the cat's lateral geniculate nucleus. | this paper describes the temporal tuning of cells in the lateral geniculate nucleus of the cat (27 x cells, 51 y cells) and how this changes with stimulus contrast. drifting sinusoidal gratings of optimal spatial frequency were presented at 7 temporal frequencies (0.5, 1, 2, 4, 8, 16 and 32 hz) and 4 contrasts (10, 20, 40, 80%). for some cells response growth at all temporal frequencies was proportional to changes in contrast. thus, their temporal tuning functions, on log-log axes, were displace ... | 1987 | 3609203 |
| extent of fiber regeneration after peripheral nerve repair: silicone splint vs. suture, gap repair vs. graft. | the degree of regeneration in surgically repaired sciatic nerves in rats was measured using a simple new electrophysiologic method: comparison of the size of nerve responses evoked by stimulation distal and proximal to the anastomosis. five different repair procedures were evaluated. after simple end-to-end suture anastomosis, about 40% of the severed parent fibers regenerated past the suture line. the result was substantially improved when the anastomosis was covered with a newly designed thinw ... | 1987 | 3609219 |
| [ventilatory response to a hypercapnic stimulus as an index of the reactivity of the human respiratory system]. | 1987 | 3609356 | |
| a new antitumor antibiotic, fr-900482. ii. production, isolation, characterization and biological activity. | fr-900482 is a new antitumor antibiotic produced by a new actinomyces named streptomyces sandaensis no. 6897. it exhibits potent cytotoxic activity against various tumor cells in vitro. furthermore, it has weak antimicrobial activity against some gram-positive or gram-negative bacteria. | 1987 | 3610818 |
| a bioserogroup of marine vibrios possessing somatic antigen factors in common with vibrio cholerae o1. | a bioserogroup of halophilic vibrios, tentatively labelled bioserogroup 1875, strongly agglutinated by o1 antiserum of vibrio cholerae is described. cross-agglutination and agglutinin-absorption tests showed that these vibrios had antigens identical with the ogawa and inaba factors of v. cholerae o1, although they possessed their own specific antigen distinctive from the a factor that is the specific major antigen of the latter species. in addition, quantitative antigen variation similar to that ... | 1987 | 3610890 |
| immunological responses of rabbits to various somatic and secreted antigens of vibrio cholerae after intra-duodenal inoculation. | the immunological responses of rabbits after intra-duodenal immunisation with live vibrio cholerae organisms were studied in various body fluids. serum, bile and intestinal samples were collected from rabbits at different times (1-8 weeks) after immunisation. three different extracts from the small intestine were prepared. at first the small intestine was washed with saline (method a). later, ultrasonic lysates were prepared from epithelial cells separated with citrate (method b) and of mucosal ... | 1987 | 3612742 |
| effect of organic vehicles on the pharmacokinetics of aminophylline administered intravenously to goats. | aminophylline dissolved in water, propylene glycol, or dimethyl sulfoxide was administered intravenously to goats in a randomized cross-over experiment. model-dependent and model-independent pharmacokinetic parameters for theophylline were compared on the basis of the solvent used in the dosage form administered. no difference was found in any pharmacokinetic parameter. thus, we found no evidence for the possibility that the organic solvents studied would confound pharmacokinetic investigations ... | 1987 | 3612942 |
| new method for serological typing of vibrio cholerae 0:1 [corrected] using a monoclonal antibody-sensitized latex agglutination test. | 1987 | 3613995 | |
| epidemiological characteristics of an institutional outbreak of cholera. | an outbreak of cholera caused by vibrio cholerae 01, biotype el tor, serotype inaba, phage type 4, occurred in an institution for the aged in singapore in august and september 1984. 96 inmates were infected (21 symptomatic and 75 asymptomatic) and 5 died. the index case was a 72-year-old male inmate who continued to assist in food preparation in the kitchen from the time of onset of diarrhoea until he was seriously ill and hospitalized 4 days later. another kitchen helper was found to have asymp ... | 1987 | 3617183 |
| [significance of scanning electron microscopy observations on cellular reactions in the biological evaluation of endoprosthetic materials]. | in a scanning electron microscopic study there are described the adhesion, spreading and formation of confluent monolayers from fibroblasts and epithelioid cells on al2o3-ceramics and cobalt-basis-alloys in relation to vitreous carbon and glass. the morphogenetic reactions of cultured cells were not significantly different in pattern, behaviour and kinetics on various biomaterials. the cells adhered, spread, migrated and proliferated on the surface of biomaterials to be tested. this allows the c ... | 1987 | 3617847 |
| [effect of hydrocortisone on the behavior of mediators of the adrenergic system (dopamine, noradrenaline and homovanillic acid) in the liver during experimental endotoxic shock]. | the influence of hydrocortisone on the behaviour of the concentration of dopamine (da), noradrenaline (na), and homovanillic acid (hva) were estimated in liver homogenates in the course of the experimental endotoxic shock. the concentration of da and na decrease in untreated animals in the 2nd and 4th hour in order to increase significantly in the 6th hour. the concentration of the hva also increased in the 6th hour after a transitory significant decrease. - the values in the treated animals wer ... | 1987 | 3617848 |
| [ideal experimental microsurgical methods in vasovasostomy and vasoepididymostomy]. | the vasovasostomy with the double-layered end-to-end anastomosis by silber is a microsurgical ideal method. we think we found experimentally an ideal method for the vasoepididymostomy with the open end-to-side anastomosis and direct spermato-tight microsurgical suture. specialties of the species rat and dog have to be observed. restrictions of the anastomotic region lead to infertility. | 1987 | 3617849 |
| cellular mechanisms of potassium homeostasis in the mammalian nervous system. | double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of k+, na+, and cl- (aki, anai, acli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex. in sympathetic neurones, carbachol and gamma-aminobutyric acid (gaba) produced a reversible decrease of aki. the decrease of aki during carbachol was accompanied by a rise of anai, whereas in the presence of gaba decreases of aki and acli were seen. th ... | 1987 | 3621030 |
| fluorometric detection of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and their n-acetylated metabolites excreted by the rat. | a sensitive fluorometric method has been developed for the determination of carcinogenic amino imidazoazaarenes (aia compounds) which are formed during the cooking of food. they are separated by t.l.c. followed by spraying with dimethylsulfoxide and visualization by long-wave u.v. light. quantification is done by fluorescence scanning. this method was applied to the determination of the metabolites in urine and feces from rats given 5 mg/kg body wt i.p. of 2-amino-3-methylimidazo[4,5-f]quinoline ... | 1987 | 3621465 |
| differences in the stimulation of repair replication by 3-aminobenzamide in lymphoblastoid cells damaged by methylmethanesulfonate or ultraviolet light. | human lymphoblastoid cells damaged by u.v. light accumulated dna breaks in the presence of cytosine arabinoside and hydroxyurea at a frequency similar to that of cells damaged by methylmethanesulfonate. 3-aminobenzamide (1 mm) reduced the net strand-break frequency detected after either kind of damage. repair replication, however, was stimulated only in methylmethanesulfonate-damaged cells. this stimulation is therefore not related directly to the dna strand-break frequencies and concomitant pol ... | 1987 | 3621467 |
| the contribution of afferent information on position and velocity to the control of slow and fast human forearm movements. | we applied vibration at various rates to the biceps tendon of a passive, restrained arm in normal human subjects and measured its effect on the perception of forearm position and the perception of forearm velocity. the disturbances of limb position perception and limb velocity perception depended on the vibration rate in distinctly different ways. we thereupon applied vibration at various rates to the biceps tendon during the performances of non-visually-guided slow and fast forearm movements. t ... | 1987 | 3622680 |
| covalent coupling of bovine growth hormone to its receptor in bovine liver membranes. | the structure of bovine somatotropin receptor was examined following covalent coupling of iodinated recombinant bovine growth hormone ([125i]rbgh) to bovine liver membrane receptors using ethylene glycol bis(succinimidyl succinate). iodinated rbgh was incorporated into a complex of estimated mr of 140,000 under reducing conditions. excess unlabeled rbgh, but not bovine prolactin (bprl), inhibited completely the incorporation of [125i]rbgh into the mr = 140,000 species. in dairy bulls, the mr = 1 ... | 1987 | 3622922 |
| motor responses of the small intestine to intraluminal distension in normal volunteers and a patient with visceral neuropathy. | the motor responses of the small intestine to intraluminal distension were studied proximal and distal to an inflatable balloon in 13 normal volunteers. during fasting, distension rapidly induced a persistent localised inhibition of distal contractile activity with a small proximal increase. proximally, phase iii activity was unaffected during distension but its propagation across and appearance below the balloon was inhibited. upon deflating the balloon a normal motor pattern rapidly returned. ... | 1987 | 3623218 |
| in vivo adherence and colonization of vibrio cholerae strains that differ in hemagglutinating activity and motility. | a scanning electron microscopic study was carried out to compare the in vivo pathogenicity of two strains of vibrio cholerae in an adult rabbit ligated-gut test model. v. cholerae c5 (serotype ogawa, biotype el tor), a motile strain possessing hemagglutinating activity in vitro, and c21 (serotype ogawa, classical biotype), a nonmotile strain possessing no hemagglutinating activity, were tested. tissue samples from small intestinal loops were examined 3, 6, 9, and 12 h postinoculation. contradict ... | 1987 | 3623694 |
| abnormality in actin polymerization associated with defective chemotaxis in neutrophils from neonates. | in an attempt to determine the mechanism of the profound defect in chemotaxis observed in the neutrophils of human neonates, we have examined the generation of polymerized or filamentous actin (f actin) following stimulation of the cells with chemotactic factors. we have also examined the changes in the intracellular levels of free calcium in neonatal neutrophils and compared the results with those in adult neutrophils. following exposure to formyl-methionyl-leucyl-phenylalanine (fmlp) or zymosa ... | 1987 | 3623709 |
| candida tropicalis infection in normal, diabetic, and neutropenic mice. | opportunistic infections caused by candida tropicalis have been noted with increasing frequency in compromised patients. the pathogenicity of three isolates of c. tropicalis was studied in normal cd-1 mice, streptozotocin-induced diabetic mice, and cyclophosphamide-induced neutropenic mice. lethal dose 50% endpoints and quantitative distribution of yeast cells in spleen, liver, and kidneys of mice infected intravenously were determined. the virulence of one yeast isolate was greater than that of ... | 1987 | 3624439 |
| physiological evidence for branching of peripheral unmyelinated sensory afferent fibers in the rat. | single unmyelinated sensory afferent nerve fibers were recorded in dorsal root filaments in urethane-anesthetized or in decerebrate-spinal rats. the peripheral branch of these axons ran in the sural nerve where they were stimulated by tungsten microelectrodes. all action potentials showed the characteristics of single fiber responses with a fixed all or none shape and a fixed latency at a given stimulus strength. in all units, the action potential evoked from a proximal stimulus site collided wi ... | 1987 | 3624540 |
| intrinsic circuitry involving the local axon collaterals of corticothalamic projection cells in mouse smi cortex. | the objective of this study was to identify the components involved in a local synaptic circuit in the mouse cerebral cortex. the local axon collaterals of corticothalamic (ct) projection cells in the posteromedial barrel subfield area of primary somatosensory cortex were labeled by the retrograde transport of horseradish peroxidase injected into the ipsilateral thalamus. thalamocortical (tc) axon terminals in the same region of cortex were labeled by lesion induced degeneration. ct axon termina ... | 1987 | 3624546 |
| development of the rhesus monkey retina: ii. a three-dimensional analysis of the sequences of synaptic combinations in the inner plexiform layer. | the inner plexiform layer (ipl) of the retina provides a useful model for ultrastructural analysis of synaptic development. in primates, the ipl consists of numerous combinations of neuronal contacts that assume the morphological configuration of either conventional or ribbon synapses. we have determined the sequential development of these combinations by analyzing serial electron microscopic sections from fetal rhesus monkeys. our analysis reveals an orderly emergence of various pre- and postsy ... | 1987 | 3624556 |
| regulation of bovine adipose tissue metabolism during lactation. 3. adaptations of hormone-sensitive and lipoprotein lipases. | activity of lipases in adipose tissue during pregnancy and lactation was investigated in holstein cows producing 5950 to 10,000 kg milk per 305 d. activity of cytoplasmic lipoprotein lipase per gram of tissue was 97, 78, 140, 162, 179, and 235% of 30 d prepartum at -15, 15, 30, 60, 180, and 349 d about calving in yr 1. in yr 2, lipoprotein lipase per gram was 100, 259, 838, 791, and 430% of -30 d at -15, 30, 60, 120, and 180 d. adaptations in activity per milligram cytoplasm protein were similar ... | 1987 | 3624592 |
| on the role of cortical area v4 in the discrimination of hue and pattern in macaque monkeys. | cortical visual area v4 in macaque monkeys has a large proportion of neurons that are sensitive to the wavelength or to the color of light. we tested its role in hue discrimination by removing it in macaque monkeys trained to discriminate small differences in hue. hue discrimination thresholds were permanently elevated in 4 macaque monkeys in which v4 was removed bilaterally. in contrast, there was no impairment in achromatic intensity thresholds tested in an identical manner. however, the discr ... | 1987 | 3625265 |
| the reduction of sulphinpyrazone and sulindac by intestinal bacteria. | 1. incubation of human or rabbit faeces with sulphinpyrazone gave greater reduction under anaerobic than under aerobic conditions. reduction of sulindac by human faeces was more extensive than that of sulphinpyrazone. 2. growth of mixed cultures of intestinal bacteria in nutrient media containing antibiotics produced a marked inhibition in their ability to reduce sulphinpyrazone. sulphide formation was inhibited by metronidazole and lincomycin for human faeces and by tetracycline for rabbit faec ... | 1987 | 3630204 |
| the development and application of a bacteriocinogenotyping scheme for vibrio cholerae non-group o-1 strains. | 423 vibrio cholerae non-group o-1 strains were tested for vibriocin production using a homologous set of 7 indicator strains. using this scheme, 334 (79.4%) strains proved to be typable. the strains isolated from 7 different geographical areas of romania exhibited 16 different patterns of vibriocin production. the presence of a predominant pattern per year and per region was revealed. | 1987 | 3630474 |
| [seasonal fluctuations in the antibiotic sensitivity of vibrio cholerae]. | sensitivity of group 01 vibrio cholerae to 6 antibiotics including tetracycline, ampicillin, benzylpenicillin, polymyxin m, erythromycin and novobiocin was studied during various seasons within 3 years. the antibiotic sensitivity of the cultures was assayed with the method of two-fold dilutions in solid medium agv. the "clonal sensitivity" of the populations of the same strains was estimated by the original method developed by the authors. there were observed seasonal biorhythms in manifestation ... | 1987 | 3631933 |
| isoperiodic bursting by magnocellular neuroendocrine cells in the rat hypothalamic slice. | 1. recruitment of magnocellular neuroendocrine cells (m.n.c.s) to a repetitive burst pattern (phasic firing) is associated with increased vasopressin secretion from neurohypophysial terminals in the intact animal. based on invertebrate studies, bursts of action potentials can arise in two distinct ways: as an intrinsic property of the recorded cell or as an emergent property of synaptic interactions. 2. the majority of phasic m.n.c.s in the hypothalamic slice preparation display an endogenous pa ... | 1987 | 3656153 |
| photoperiodic modification of negative and positive feedback effects of oestradiol on lh secretion in ovariectomized goats. | ovariectomized shiba goats carrying an oestradiol implant (4-10 pg/ml) were kept under a short-day light regimen (10l:14d; group 1, n = 4) or a long-day regimen (16l:8d; group 2, n = 4). plasma lh concentrations were lower (p less than 0.05) in group 2 than in group 1 between days 40 and 200, suggesting an enhanced negative feedback effect of oestradiol on lh secretion under a long-day regimen. on days 30, 60, 100, 149 and 279, an lh surge was induced by i.v. infusion of oestradiol for 48 h; the ... | 1987 | 3656284 |
| studies of chlorpromazine-induced enhancement of the potentials evoked by peripheral stimulation of the cat cerebellum. | 1) in the experiments reported here, we investigated effects of cpz on the amplitude of cerebellar potentials using decerebrated or spinal cat; furthermore, we also examined the effects of microinjecting cpz, da or ne into the precerebellar nuclei on the amplitude of the cerebellar potentials. 2) purkinje cell spontaneous discharge was either hardly changed or was depressed by cpz. 3) cpz did not change the potentials evoked by peripheral stimulation on the dorsal surface of the spinal cord. 4) ... | 1987 | 3656785 |
| antibodies against vibrio cholerae lipopolysaccharide, cell-bound haemagglutinin and toxin in the intestinal fluid during convalescence. | specific antibodies to v. cholerae lipopolysaccharide (lps), cell-bound haemagglutinin (cha) and toxin (ct) in the intestinal lavages of healthy thais and thai cholera patients during the convalescence period were determined by enzyme-linked immunosorbent assay. only igm and iga specific antibodies were detectable in the specimens. all of the persons who were just recovered from cholera had iga anti-ct and iga anti-lps and 82.4% had iga anti-cha. the iga anti-ct, anti-lps and anti-cha were detec ... | 1987 | 3660066 |
| quantitation of cellular and extracellular constituents of the pulmonary lining in rats by using bronchoalveolar lavage. effects of silica-induced pulmonary inflammation. | the efficacy of bronchoalveolar lavage in the removal of cellular and extracellular components of the lining layer from the lungs of silica-treated and control rats was determined. exponential functions were fitted to curves generated by plotting the quantity of lining layer constituent removed from the lungs by bronchoalveolar lavage versus the lavage number. from these exponential functions we determined the total amount of constituent available in the pulmonary extracellular lining and hence ... | 1987 | 3662242 |