Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| attacking hepatitis b virus cccdna--the holy grail to hepatitis b cure. | hbv deposits a covalently closed circular dna form, called cccdna, in the nucleus of infected cells. as the central transcription template, the cccdna minichromosome is a key intermediate in the hbv life cycle. its location in the nucleus makes cccdna a difficult target for antivirals and immune response, and therefore it is responsible for chronicity of hbv infection. while little is known about the mechanisms involved in cccdna formation, current research is accumulating data on the mechanisms ... | 2016 | 27084036 |
| overview of hepatitis b viral replication and genetic variability. | chronic infection with hepatitis b virus (hbv) greatly increases the risk for liver cirrhosis and hepatocellular carcinoma (hcc). hbv isolates worldwide can be divided into ten genotypes. moreover, the immune clearance phase selects for mutations in different parts of the viral genome. the outcome of hbv infection is shaped by the complex interplay of the mode of transmission, host genetic factors, viral genotype and adaptive mutations, as well as environmental factors. core promoter mutations a ... | 2016 | 27084035 |
| entry of hepatitis b and hepatitis d virus into hepatocytes: basic insights and clinical implications. | for almost three decades following the discovery of the human hepatitis b virus (hbv) the early events of virus infection (attachment to hepatocytes, specific binding to a receptor on hepatocytes) remained enigmatic. the gradual improvement of tissue culture systems for hbv has enabled the identification of viral determinants for viral infectivity and facilitated the discovery of the human sodium taurocholate co-transporting polypeptide (hntcp) as a liver specific receptor of hbv and its satelli ... | 2016 | 27084034 |
| experimental in vitro and in vivo models for the study of human hepatitis b virus infection. | chronic infection with the hepatitis b virus (hbv) affects an estimate of 240 million people worldwide despite the availability of a preventive vaccine. medication to repress viral replication is available but a cure is rarely achieved. the narrow species and tissue tropism of the virus and the lack of reliable in vitro models and laboratory animals susceptible to hbv infection, have limited research progress in the past. as a result, several aspects of the hbv life cycle as well as the network ... | 2016 | 27084033 |
| new antiviral targets for innovative treatment concepts for hepatitis b virus and hepatitis delta virus. | current therapies of chronic hepatitis b (chb) remain limited to pegylated-interferon-alpha (pegifn-α) or any of the five approved nucleos(t)ide analogues (nuc) treatments. while viral suppression can be achieved in the majority of patients with the high-barrier-to-resistance new-generation of nuc, i.e. entecavir and tenofovir, hbsag loss is achieved by pegifn-α and/or nuc in only 10% of patients, after a 5-year follow-up. attempts to improve the response by administering two different nuc or a ... | 2016 | 27084032 |
| the hepatitis delta virus: replication and pathogenesis. | hepatitis delta virus (hdv) is a defective virus and a satellite of the hepatitis b virus (hbv). its rna genome is unique among animal viruses, but it shares common features with some plant viroids, including a replication mechanism that uses a host rna polymerase. in infected cells, hdv genome replication and formation of a nucleocapsid-like ribonucleoprotein (rnp) are independent of hbv. but the rnp cannot exit, and therefore propagate, in the absence of hbv, as the latter supplies the propaga ... | 2016 | 27084031 |
| association of hla-dp variants with the responsiveness to hepatitis b virus vaccination in korean infants. | recently, hla-dp single nucleotide polymorphisms (snps) have been reported to be related to responsiveness to hepatitis b virus (hbv) vaccination. the aim of this study was to investigate associations between hla-dp snps and responsiveness to hbv vaccine in korean infants. a total of 290 healthy korean infants who were registered to seoul metropolitan public cord blood bank during the period of february 2007 to december 2011 were enrolled. anti-hbs antibody level was analyzed after three doses o ... | 2016 | 27083422 |
| anti-hbv activity and mechanism of marine-derived polyguluronate sulfate (pgs) in vitro. | polyguluronate sulfate (pgs) is a low molecular-weight sulfated derivative, which has a structure of 2,3-o-disulfated-1,4-poly-l-guluronic acid (pg) with about 1.5 sulfate per sugar residue. herein, our results showed that pgs effectively inhibited the expression and secretion of hbsag and hbeag in hepg2.2.15 cells. pgs could bind and enter into hepg2.2.15 cells to interfere with hbv transcription rather than blocking hbv dna replication. moreover, pgs also enhanced the production and secretion ... | 2016 | 27083353 |
| expression of dbc1 is associated with poor prognosis in hepatitis virus-related hepatocellular carcinoma. | deleted in breast cancer 1 (dbc1) is a nuclear protein that was named by its deletion at a region 8p21 in some breast cancers and has been suggested as a poor prognostic indicator of various human cancers. however, the expression level of dbc1 protein and the prognostic role of dbc1 in hepatocellular carcinoma (hcc) have not been reported. | 2016 | 27083241 |
| the hepatitis viral status in patients with hepatocellular carcinoma: a study of 3843 patients from taiwan liver cancer network. | hepatocellular carcinoma (hcc) is the leading cancer death in taiwan. chronic viral hepatitis infections have long been considered as the most important risk factors for hcc in taiwan. the previously published reports were either carried out by individual investigators with small patient numbers or by large endemic studies with limited viral marker data. through collaboration with 5 medical centers across taiwan, taiwan liver cancer network (tlcn) was established in 2005. all participating cente ... | 2016 | 27082566 |
| human immunodeficiency virus, hepatitis b virus and hepatitis c virus seroprevalence in critically ill emergency department patients at a trauma care centre, india. | human immunodeficiency virus (hiv), hepatitis b virus (hbv) and hepatitis c virus (hcv) are the most common occupationally acquired infections amongst the healthcare workers (hcws) with critically ill patients attending the emergency department being the most common source of occupationally acquired infections. therefore, the present study was conducted at a 165 bedded level-1 trauma centre of india to ascertain the seroprevalence rate of hiv, hbv and hcv; and thus the risk associated with the o ... | 2016 | 27080769 |
| stratification of digestive cancers with different pathological features and survival outcomes by microrna expression. | micrornas (mirnas) are aberrantly expressed in virtually all cancer types, including digestive cancers. herein, we aggregated and systematically analyzed mirna expression profiles of 1765 tumor samples, including esophageal, gastric, liver, pancreatic, colon and rectal cancers, obtained through small rna sequencing by the cancer genome atlas. we found that digestive cancers of different tissue origins could be differentiated according to their mirna expression profiles. in particular, esophageal ... | 2016 | 27080237 |
| gene polymorphisms of macrophage migration inhibitory factor affect susceptibility to chronic hepatitis b virus infection in an iranian cohort. | macrophage migration inhibitory factor (mif), a key proinflammatory mediator, plays important roles in chronic diseases. in this study, an attempt was made to clarify the associations between some functional polymorphisms such as mif-173 g/c, mif 95 bp and 189 bp insertion/deletion (i/d) polymorphisms and chronic hepatitis b virus (hbv) infection. polymorphisms were assessed in 221 hbv patients and 200 normal subjects. mif-173 g/c and mif 95 bp and 189 bp i/d polymorphisms were genotyped using p ... | 2016 | 27079941 |
| de novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine. | entecavir-resistance mutations are commonly induced by entecavir treatment in chronic hepatitis b patients. however, entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations induced by sequential or combination treatment with lamivudine and adefovir dipivoxil have never been reported. | 2016 | 27079793 |
| rassf1a and dok1 promoter methylation levels in hepatocellular carcinoma, cirrhotic and non-cirrhotic liver, and correlation with liver cancer in brazilian patients. | hepatocellular carcinoma (hcc) is the second most common cause of cancer mortality worldwide. most cases of hcc are associated with cirrhosis related to chronic hepatitis b virus or hepatitis c virus infections. hypermethylation of promoter regions is the main epigenetic mechanism of gene silencing and has been involved in hcc development. the aim of this study was to determine whether aberrant methylation of rassf1a and dok1 gene promoters is associated with the progression of liver disease in ... | 2016 | 27078152 |
| oncogenic wnt3a expression as an estimable prognostic marker for hepatocellular carcinoma. | to investigate member 3a of wingless-type mmtv integration site family (wnt3a) expression in cancerous and surrounding tissues and the relationship between clinicopathologic features of hepatocellular carcinoma (hcc) and wnt3a expression. | 2016 | 27076768 |
| high-dose hepatitis b immunoglobulin therapy in hepatocellular carcinoma with hepatitis b virus-dna/hepatitis b e antigen-positive patients after living donor liver transplantation. | to investigate the impact of high-dose hepatitis b immunoglobulin (hbig) on hepatocellular carcinoma (hcc) and hepatitis b virus (hbv) recurrence and overall survival after living donor liver transplantation (ldlt). | 2016 | 27076765 |
| cell-free hepatitis b virus capsid assembly dependent on the core protein c-terminal domain and regulated by phosphorylation. | multiple subunits of the hepatitis b virus (hbv) core protein (hbc) assemble into an icosahedral capsid that packages the viral pregenomic rna (pgrna). the n-terminal domain (ntd) of hbc is sufficient for capsid assembly, in the absence of pgrna or any other viral or host factors, under conditions of high hbc and/or salt concentrations. the c-terminal domain (ctd) is deemed dispensable for capsid assembly although it is essential for pgrna packaging. we report here that hbc expressed in a mammal ... | 2016 | 27076641 |
| transmission of hepatitis b core antibody and galactomannan enzyme immunoassay positivity via immunoglobulin products: a comprehensive analysis. | therapeutic immunoglobulins are used as replacement or immunomodulatory therapy, but can transmit clinically important molecules. we investigated hepatitis b virus (hbv) antibodies and galactomannan enzyme immunoassay (gm-eia) positivity. detection of hbv core antibody may prompt antiviral prophylaxis when commencing therapy such as rituximab; a positive gm-eia result prompts investigation or treatment for invasive fungal disease. | 2016 | 27076567 |
| occult hbv infection in the oncohematological setting. | occult hepatitis b infection (obi), a virological condition characterized by a low release of hepatitis b virus (hbv) from liver cells and low hbv-dna levels in serum and/or liver tissue of hbsag-negative subjects, may reactivate in oncohematological patients undergoing immunosuppression by aggressive chemotherapy or hematopoietic stem cell transplantation. the entity of obi reactivation varies from an increase in hbv replication without liver damage to an active hbv replication followed by live ... | 2016 | 27076347 |
| prediction model for sustained hepatitis b e antigen seroconversion to peginterferon alfa-2a in chronic hepatitis b. | clinically applicable models to predict hepatitis b e antigen (hbeag)-positive chronic hepatitis b (chb) response to peginterferon (peg-ifn) are scarce. this study aimed to develop simple scoring systems, based on multiple parameters, for predicting sustained hbeag seroconversion to peg-ifn. | 2016 | 27075693 |
| hepatitis b and human immunodeficiency virus co-infection among pregnant women in resource-limited high endemic setting, addis ababa, ethiopia: implications for prevention and control measures. | hepatitis, a highly contagious viral infection, is one of the leading killer diseases globally caused by hepatitis virus. among the existing viral causes for hepatic failure, hepatitis b virus (hbv) plays a significant role with devastating implications, especially when combined with other viral infections such as human immunodeficiency virus (hiv). co-infection with hepatitis b virus and hiv leads to increased morbidity and mortality as compared to independent hiv and hbv infections. in this st ... | 2016 | 27075475 |
| hepatitis b virus x protein (hbx)-induced abnormalities of nucleic acid metabolism revealed by (1)h-nmr-based metabonomics. | hepatitis b virus x protein (hbx) plays an important role in hbv-related hepatocarcinogenesis; however, mechanisms underlying hbx-mediated carcinogenesis remain unclear. in this study, an nmr-based metabolomics approach was applied to systematically investigate the effects of hbx on cell metabolism. edu incorporation assay was conducted to examine the effects of hbx on dna synthesis, an important feature of nucleic acid metabolism. the results revealed that hbx disrupted metabolism of glucose, l ... | 2016 | 27075403 |
| hepatitis b virus mutations, expression quantitative trait loci for ptpn12, and their interactions in hepatocellular carcinoma. | previously we identified that hbv(hepatitis b virus) sequence variation, which may interact with host human leukocyte antigen (hla) genetic variation, could influence host risk of hepatocellular carcinoma (hcc). more hbv-host interactions need to be identified. protein tyrosine phosphatase nonreceptor type 12 (ptpn12), serves as an antagonist to tyrosine kinase signaling, may play integral roles in immune response against hbv infection and the development of hcc. rs11485985 was an expression qua ... | 2016 | 27075395 |
| immunogenicity of leishmania-derived hepatitis b small surface antigen particles exposing highly conserved e2 epitope of hepatitis c virus. | hepatitis c virus (hcv) infection is a major health problem worldwide, affecting an estimated 2-3 % of human population. an hcv vaccine, however, remains unavailable. high viral diversity poses a challenge in developing a vaccine capable of eliciting a broad neutralizing antibody response against all hcv genotypes. the small surface antigen (shbsag) of hepatitis b virus (hbv) has the ability to form highly immunogenic subviral particles which are currently used as an efficient anti-hbv vaccine. ... | 2016 | 27075377 |
| efficacy and safety of a steroid-free immunosuppressive regimen after liver transplantation for hepatocellular carcinoma. | we aimed to evaluate the efficacy and safety of an immunosuppressive regimen without steroids after liver transplantation (lt) for hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc). | 2016 | 27074818 |
| efficacy of entecavir and tenofovir in chronic hepatitis b under treatment in the public health system in southern brazil. | there are about 350 million hepatitis b virus (hbv) carriers worldwide and chronic hbv is considered a major public health problem. the objective of the present study was to assess the effectiveness of the nucleos(t)ide analogues tenofovir (tdf) and entecavir (etv) in the treatment of chronic hbv. a cross-sectional study was carried out from march-december 2013, including all patients with chronic hbv, over 18 years of age, undergoing therapy through the public health system in southern brazil. ... | 2016 | 27074254 |
| microrna-125a-5p contributes to hepatic stellate cell activation through targeting fih1. | emerging evidence shows that micrornas (mirnas) play a crucial role in the regulation of activation, proliferation and apoptosis of hepatic stellate cells (hscs). previous studies have indicated that mir-125a-5p is correlated with hepatitis b virus replication and disease progression. however, little is known about the biological role and underlying mechanism of mir-125a-5p in liver fibrosis. | 2016 | 27074047 |
| combined detection of liver stiffness and c-reactive protein in patients with hepatitis b virus-related liver cirrhosis, with and without hepatocellular carcinoma. | the aim of the present study was to investigate the usefulness of combined detection of liver stiffness (ls) and serum c-reactive protein (crp) level in patients with hepatitis b virus (hbv)-related liver cirrhosis (lc). a total of 156 cases of previously untreated patients with hbv-related lc were classified into the lc group [lc without hepatocellular carcinoma (hcc)] and the hcc group (lc with hcc). comparative analyses of ls and serum crp level were conducted between these two groups. ls val ... | 2016 | 27073669 |
| cimicifuga foetida l. plus adefovir effectively inhibits the replication of hepatitis b virus in patients with chronic hepatitis b. | the aim of the present study was to assess the anti-hepatitis b virus (hbv) effect of cimicifuga foetida l. (c. foetida) in the patients with chronic hepatitis b (chb). a total of 60 randomly selected patients with chb were recruited and divided into groups i and ii. the patients in group i received a monotherapy of adefovir (adv), and the patients in group ii received a combination therapy of adv and c. foetida for >48 weeks. intrahepatic (ih) hbv covalently closed circular dna (cccdna), serum ... | 2016 | 27073640 |
| prognostic performance of clinical indices and model scorings for acute-on-chronic liver failure: a study of 164 patients. | the present study aimed to analyze the prognostic factors of acute-on-chronic liver failure (aclf), with the perspective of an improved selection of optimal therapeutic schemes. a retrospective analysis was used to study 164 patients with aclf hospitalized between 2010 and 2014 in a single center. patients were divided into favorable and unfavorable groups, according to the treatment outcomes. general characteristics and clinical manifestations were analyzed to determine whether they would affec ... | 2016 | 27073448 |
| prevention knowledge, risk behaviours and seroprevalence among nonurban injectors of southwest connecticut. | little is known about injection-associated risk behaviours, knowledge and seroprevalence of viral infections among people who inject drugs (pwid) in nonurban locales in the us. harm reduction services are more available in urban locales. the present study examined a cohort of active pwid residing in non urban areas of connecticut to investigate how primarily injecting in urban or non urban areas was associated with injection-associated risk behaviours, knowledge and prevalence of blood-borne vir ... | 2016 | 27073014 |
| diagnostic evaluation of des-gamma-carboxy prothrombin versus α-fetoprotein for hepatitis b virus-related hepatocellular carcinoma in china: a large-scale, multicentre study. | an efficient serum marker for hepatocellular carcinoma (hcc) is currently lacking and requires intensive exploration. we aimed to evaluate the performance of des-gamma-carboxy prothrombin (dcp) for identifying hepatitis b virus-related hcc in a large, multicentre study in china. a total of 1034 subjects in three cohorts (a, b, and c) including hcc and various non-hcc controls were enrolled from 4 academic medical centers in china from january 2011 to february 2014. blind parallel detections were ... | 2016 | 27070780 |
| prevalence of transfusion-transmissible infections in donors to an ethiopian blood bank between 2009 and 2013 and donation factors that would improve the safety of the blood supply in underdeveloped countries. | to determine the percentages of blood donors at an ethiopian blood bank who tested positive for 4 transfusion-transmissible infections (ttis) and to compare tti infection levels among individuals of different sociodemographic characteristics. | 2016 | 27069031 |
| activation-dependent mitochondrial translocation of foxp3 in human hepatocytes. | foxp3 is considered to be the master regulator for the development and function of regulatory t cells (treg). recently foxp3, has been detected in extra lymphoid tissue, and in hepatocytes and has been associated with hepatocellular carcinoma (hcc), although its role has not been defined. since it is expected that there is a relationship between protein localization, activity and cellular function, the aim of this study was to explore the subcellular localization of foxp3 in resting and stimulat ... | 2016 | 27068374 |
| humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and nk cells. | human liver chimeric mice are useful models of human hepatitis virus infection, including hepatitis b and c virus infections. independently, immunodeficient mice reconstituted with cd34(+) hematopoietic stem cells (hsc) derived from fetal liver reliably develop human t and b lymphocytes. combining these systems has long been hampered by inefficient liver reconstitution of human fetal hepatoblasts. our study aimed to enhance hepatoblast engraftment in order to create a mouse model with syngeneic ... | 2016 | 27151182 |
| occult hepatitis b virus infection in previously screened, blood donors in ile-ife, nigeria: implications for blood transfusion and stem cell transplantation. | hepatitis b virus (hbv) transmission through blood transfusion is reduced by screening for hepatitis b surface antigen (hbsag). however this method cannot detect the presence of occult hepatitis b virus infection. this study sought to determine the prevalence of occult hepatitis b virus infection among blood donors in ile-ife, nigeria. for the first time in nigeria we employed an automated real-time pcr- method to investigate the prevalence of occult hbv in blood donors. | 2016 | 27150469 |
| chemistry and bioactivities of aristeromycins: an overview. | the majority of carbocyclic nucleosides are of synthetic origin; nature has provided two of the most interesting compounds, aristeromycin and neplanocin a. aristeromycin and its modified derivatives are an important group of carbocyclic nucleosides that exhibits a wide range of pharmacological properties such as antiviral, anticancer and antitoxoplasma activities. especially, aristeromycins are widely used as antiviral agents against human immunodeficiency virus, hepatitis b virus, herpes simple ... | 2016 | 27150369 |
| mir-19a, mir-122 and mir-223 are differentially regulated by hepatitis b virus x protein and involve in cell proliferation in hepatoma cells. | hepatitis b virus (hbv) x protein (hbx) is a type of oncogenic protein involved in the progression of hepatocellular carcinoma (hcc) via interacting with host genes. dysregulation of micrornas (mirnas) has been observed in hcc. this study aimed to investigate the role of hbx protein in the regulation of mir-19a, mir-122 and mir-223, and examine if these mirnas involve in progression of malignant hepatocytes. | 2016 | 27150195 |
| generation of human liver chimeric mice for the study of human hepatotropic pathogens. | human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. the evolution of the underlying mouse models has been rapid in the past years. the diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter. | 2016 | 27150085 |
| sexual dimorphic metabolic alterations in hepatitis c virus-infected patients: a community-based study in a hepatitis b/hepatitis c virus hyperendemic area. | the impact of sex on metabolic alterations in individuals with hepatitis b virus (hbv) or hepatitis c virus (hcv) infection remains elusive.a community-based study was performed to assess sex, age, body mass index, the lipid profile, blood pressure, glucose, alanine aminotransferase, hbv surface antigen (hbsag), and hcv antibody levels, smoking and alcohol drinking habits, and cardiometabolic diseases, including diabetes, hypertension, cardiovascular events, and renal diseases. the hcv-rna level ... | 2016 | 27149466 |
| visualization of hepatitis b virus entry - novel tools and approaches to directly follow virus entry into hepatocytes. | hepatitis b virus (hbv) is a widespread human pathogen, responsible for chronic infections of ca. 240 million people worldwide. until recently, the entry pathway of hbv into hepatocytes was only partially understood. the identification of human sodium taurocholate cotransporting polypeptide (ntcp) as a bona fide receptor of hbv has provided us with new tools to investigate this pathway in more details. combined with advances in virus visualization techniques, approaches to directly visualize hbv ... | 2016 | 27149321 |
| occult hepatitis b virus infection in a previously vaccinated injection drug user. | occult hepatitis b virus (hbv) is defined by the presence of hbv dna in patient sera in the absence of hbsag. occult hbv has been associated with hepatocellular carcinoma, reactivation during immune suppression, and transmission to others. while the hepatitis b vaccine is very effective at preventing chronic hbv infection, recent studies indicate it is less effective at preventing occult hbv following infant vaccination. no studies, however, have examined the efficacy of adult hbv vaccination at ... | 2016 | 27148386 |
| association between il-10 gene promoter polymorphisms (-592 a/c, -819 t/c, -1082 a/g) and susceptibility to hbv infection in an iranian population. | il-10 can play a vital role in immune response against hbv. three biallelic snps from the transcription start site control the transcription of the il-10 gene. an association between susceptibility to hbv and il-10 polymorphisms has been suggested in patients with hbv infection. | 2016 | 27148384 |
| characteristics, diagnosis and prognosis of acute-on-chronic liver failure in cirrhosis associated to hepatitis b. | the diagnostic and prognostic criteria of acute-on-chronic liver failure (aclf) were developed in patients with no hepatitis b virus (hbv) cirrhosis (canonic study). the aims of this study were to evaluate whether the diagnostic (clif-c organ failure score; clif-c ofs) criteria can be used to classify patients; and the prognostic score (clif-c aclf score) could be used to provide prognostic information in hbv cirrhotic patients with aclf. 890 hbv associated cirrhotic patients with acute decompen ... | 2016 | 27146801 |
| outcomes of kidney transplants and risk of infection transmission from increased infectious risk donors. | concern over transmission of viral infections has been reported to result in higher discard rates of high infectious risk kidneys (hir) although data on actual viral transmission rates are lacking. at our center, we performed 89 hir and 533 non-hir kidney transplants (kts) between 2004 and 2011. follow-up screening labs in recipients of hir kidneys tested for human immunodeficiency virus, hepatitis c virus, and hepatitis b virus did not reveal any cases of viral transmission over median follow-u ... | 2016 | 27146714 |
| outcomes of liver transplantation with liver grafts from pediatric donors used in adult recipients. | although there is an agreement that liver grafts from pediatric donors (pds) should ideally be used for pediatric patients, there remain situations when these grafts are turned down for pediatric recipients and are then offered to adult recipients. the present study aimed to investigate the outcomes of using these grafts for liver transplantation (lt) in adult patients. data from all patients undergoing lt between 2002 and 2014 were obtained from the united network for organ sharing standard ana ... | 2016 | 27145067 |
| association of the mir-196a2 c>t and mir-499 a>g polymorphisms with hepatitis b virus-related hepatocellular carcinoma risk: an updated meta-analysis. | this study meta-analyzed data on the possible association of the mir-196a2 c>t (rs11614913) and mir-499 a>g (rs3746444) polymorphisms with risk of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc). | 2016 | 27143913 |
| [primary hypogammaglobulinemia complicated with liver cirrhosis and literature review]. | to explore the pathogenesis, treatment and prognosis of primary hypogammaglobulinemia complicated with liver cirrhosis in a child. | 2016 | 27143082 |
| hepatitis b viral infection of hepatic progenitor cells. resolving unresolved questions? | accumulated data to date do not entirely explain the; propensity of the hepatitis b virus (hbv) to cause chronic infections in newborns; failure of antiviral agents to resolve infections or precise mechanism whereby hbv causes hepatocellular carcinoma (hcc). based on the increased numbers of hepatic stem/progenitor cells (hpcs) present within the neonatal liver, the refractoriness of these cells to the effects of interferons and xenobiotics and their ability to undergo malignant transformation, ... | 2016 | 27142136 |
| serious adverse transfusion reactions reported in the national recipient-triggered trace back system in korea (2006-2014). | adverse transfusion reactions (atrs) are clinically relevant to patients with significant morbidity and mortality. this study aimed to review the cases of atr reported in the recipient-triggered trace back system for a recent nine-year period in korea. | 2016 | 27139606 |
| interferon-γ facilitates hepatic antiviral t cell retention for the maintenance of liver-induced systemic tolerance. | persistent exposure to liver pathogens leads to systemic antigen-specific tolerance, a major cause of chronicity during hepatotropic infection. the mechanism regarding how this systemic tolerance is maintained remains poorly elucidated. in a well established mouse model of hepatitis b virus (hbv) persistence-induced systemic tolerance, we observed that interferon-γ (ifn-γ) deficiency led to complete loss of tolerance, resulting in robust anti-hbv responses upon peripheral vaccination. the recove ... | 2016 | 27139489 |
| the clinical implications of hepatitis b virus genotypes and hbeag in pediatrics. | although a successful vaccine against hbv has been implemented in 184 countries, eradication of hepatitis b virus (hbv) is still not on the horizon. there are over 240 million chronic carriers of hbv globally. the risk of developing chronic hepatitis ranges from >90% in newborns of hepatitis be antigen (hbeag)-positive mothers, 25%-35% in children under 5 years of age and <5% in adults. hbeag, a non-particulate viral protein, is a marker of hbv replication. this is the only hbv antigen to cross ... | 2016 | 27139263 |
| epigenetically regulated mir-449a enhances hepatitis b virus replication by targeting camp-responsive element binding protein 5 and modulating hepatocytes phenotype. | cellular micrornas (mirnas) are able to influence hepatitis b virus (hbv) replication directly by binding to hbv transcripts or indirectly by targeting cellular factors. here, we investigate the effect of epigenetically regulated mir-449a on hbv replication and the underlying mechanisms. mir-449a expression was lower in human hepatocellular carcinoma (hcc) cells than in primary hepatocytes and could be induced by trichostatin a. ectopic mir-449a expression in hcc cells strongly enhanced hbv repl ... | 2016 | 27138288 |
| population-representative incidence of acute-on-chronic liver failure: a prospective cross-sectional study. | acute-on-chronic liver failure (aclf) is a major cause of hepatic death in the world, but no population-based studies have evaluated the incidence of aclf. this study was conducted to determine the incidence and short-term outcomes of aclf in a region of eastern china. | 2016 | 27136963 |
| tenofovir alafenamide (taf) as the successor of tenofovir disoproxil fumarate (tdf). | tenofovir alafenamide (taf) can be considered a new prodrug of tenofovir (tfv), as successor of tenofovir disoproxil fumarate (tdf). it is in vivo as potent against human immunodeficiency virus (hiv) at a 30-fold lower dose (10mg) than tdf (300mg). taf has been approved in november 2015 (in the us and eu), as a single-tablet regimen (str) containing 150mg elvitegravir (e), 150mg cobicistat (c), 200mg emtricitabine [(-)ftc] (f) and 10mg taf, marketed as genvoya®, on 01 march 2016 in the us as an ... | 2016 | 27133890 |
| discordant diagnostic results due to a hepatitis b virus t123a hbsag mutant. | hbsag immunoassay results are occasionally discordant among primary and confirmatory assays or with respect to other markers of hbv infection. such discordance has been observed repeatedly in canada with samples having a mutation at hbsag codon 123 (st123a). detection of recombinant expressed hbsag protein having either st123 or sa123 was evaluated with one manual and six automated hbsag immunoassays. the recombinant mutant hbsag was non-reactive by abbott axsym, while the abbott architect quant ... | 2016 | 27133305 |
| treatment of chronic hepatitis d with the entry inhibitor myrcludex b: first results of a phase ib/iia study. | the therapeutic option for patients with chronic hepatitis delta virus infection (chd) is limited to interferon alpha with rare curative outcome. myrcludex b is a first-in-class entry inhibitor inactivating the hepatitis b virus (hbv) and hepatitis d virus (hdv) receptor sodium taurocholate co-transporting polypeptide. we report the interim results of a pilot trial on chronically infected hdv patients treated with myrcludex b, or pegylated interferon alpha (pegifnα-2a) or their combination. | 2016 | 27132170 |
| hepatitis b virus basal core promoter mutations show lower replication fitness associated with cccdna acetylation status. | in chronic hepatitis b virus (hbv) infection, variants with mutations in the basal core promoter (bcp) and precore region predominate and associate with more severe disease forms. studies on their effect on viral replication remain controversial. increasing evidence shows that epigenetic modifications of cccdna regulate hbv replication and disease outcome. here we determined the transcription and viral replication efficiency of well-defined bcp and precore mutations and their effect on cccdna ep ... | 2016 | 27132039 |
| estimated exposure to eu regulated mycotoxins and risk characterization of aflatoxin-induced hepatic toxicity through the consumption of the toasted cereal flour called "gofio", a traditional food of the canary islands (spain). | "gofio" is a type of flour made from toasted grain, which is part of the staple food in the canary islands, spain, in which the occurrence of aflatoxins b1, b2, g1 and g2 (afb1, afb2, afg1, afg2), fumonisins b1 and b2 (fb1 and fb2) ochratoxin a (ota), deoxynivalenol (dnv) and zearalenone (zea) was evaluated. 83% of the samples were contaminated with at least one mycotoxin and 69.2% of the analyzed samples showed co-occurrence of mycotoxins (range 2 to 8). all the concentrations were well below t ... | 2016 | 27132021 |
| serologic and molecular characteristics of hepatitis b virus infection in vaccinated schizophrenia patients in china. | previous studies have indicated that the patients with psychiatric illness were at higher risk of hepatitis b virus (hbv) infection. however, the efficacy of hepatitis b vaccine in schizophrenia patients remains unclear. | 2016 | 27131009 |
| rising incidence of hepatitis b-related hepatocellular carcinoma in south australia: 1996-2010. | chronic hepatitis b virus (hbv) infection is likely to be an important driver of increasing hepatocellular carcinoma (hcc) incidence in australia. however, there is paucity of australian data on hbv-related hcc incidence or outcomes. | 2016 | 27130077 |
| a scorpion defensin bmkdfsin4 inhibits hepatitis b virus replication in vitro. | hepatitis b virus (hbv) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (hcc). nowadays, clinical therapies of hbv infection still mainly rely on nucleotide analogs and interferons, the usage of which is limited by drug-resistant mutation or side effects. defensins had been reported to effectively inhibit the proliferation of bacteria, fungi, parasites and vir ... | 2016 | 27128943 |
| deazaflavin inhibitors of tyrosyl-dna phosphodiesterase 2 (tdp2) specific for the human enzyme and active against cellular tdp2. | tyrosyl-dna phosphodiesterase 2 repairs irreversible topoisomerase ii-mediated cleavage complexes generated by anticancer topoisomerase-targeted drugs and processes replication intermediates for picornaviruses (vpg unlinkase) and hepatitis b virus. there is currently no tdp2 inhibitor in clinical development. here, we report a series of deazaflavin derivatives that selectively inhibit the human tdp2 enzyme in a competitive manner both with recombinant and native tdp2. we show that mouse, fish, a ... | 2016 | 27128689 |
| the prevalence of hepatitis b and c among prisoners in kahramanmaras, turkey. | hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are among the most important health issues in turkey. human immunodeficiency virus (hiv) infections are less frequently observed in the country. the individuals who had blood transfusions, patients undergoing hemodialysis, and intravenous drug addicted individuals, people who had tattoos/piercings, communal living environments, contamination of a family member, and prisoners are the main risk groups. | 2016 | 27127594 |
| [tlr9 expression is positively correlated with the levels of cd38, hla-dr and cd95 on peripheral blood mononuclear cells in chronic hbv infected patients]. | to explore the relationship between the expression of tlr9 and the levels of cd38, hla-dr and cd95 on peripheral blood mononuclear cells (pbmcs) of chronic hepatitis b virus (hbv) infected patients. | 2016 | 27126946 |
| the potential protective role of hepatitis b virus infection in pristane-induced lupus in mice. | the objective of this study was to investigate whether hepatitis b virus (hbv) infection plays a role in the regulation of autoimmunity for systemic lupus erythematosus (sle). | 2016 | 27125291 |
| relationship between hepatic steatosis and the elevation of aminotransferases in hbv-infected patients with hbe-antigen negativity and a low viral load. | nonalcoholic fatty liver disease has been suggested to be associated with alanine aminotransferase (alt) elevation in hepatitis b virus (hbv)-infected patients with hbe antigen (hbeag)-negativity and a low hbv-dna level. however, few studies have evaluated the association according to histological findings of the liver.among a total of 198 hbv-infected patients who received a percutaneous liver biopsy, we studied the histological and laboratory findings of hbeag-negative patients without receivi ... | 2016 | 27124068 |
| multiple primary malignancies in patients with hepatocellular carcinoma: a largest series with 26-year follow-up. | multiple primary malignancies (mpms) are defined as 2 or more malignancies without subordinate relationship detected in different organs of an individual patient. reports addressing mpm patients with hepatocellular carcinoma (hcc) are rare. we perform a 26-year follow-up study to investigate characteristics and prognosis of mpm patients associated with hcc due to the scarcity of relative researches.we retrospectively analyzed records of 40 patients who were diagnosed with mpm including hcc at th ... | 2016 | 27124050 |
| predictive factors of spontaneous bacterial peritonitis caused by gram-positive bacteria in patients with cirrhosis. | spontaneous bacterial peritonitis (sbp) in patients with cirrhosis is typically caused by gram-negative bacteria. however, the number of sbp cases due to gram-positive bacteria is steadily increasing. to date, little is known about the predictive factors involved in sbp infections.we performed a retrospective cohort study of patients (>18 years) with sbp due to gram-positive and -negative bacteria who were enrolled from january 2006 to december 2013 at severance hospital in seoul, korea where th ... | 2016 | 27124049 |
| prospective clinical trial of hepatitis b vaccination in adults with and without type-2 diabetes mellitus. | objective: patients with diabetes mellitus are at increased risk for hepatitis b virus (hbv) infection and its complications. hbv vaccination is recommended for adults with diabetes in the united states and other countries. however, few studies have assessed safety and immunogenicity of hepatitis b vaccine in such patients. we assessed the safety and immunogenicity of recombinant hepatitis b vaccine in subjects with and without diabetes mellitus. | 2016 | 27123743 |
| radiation-induced optic neuropathy following external beam radiation therapy for nasopharyngeal carcinoma: a retrospective case-control study. | radiation-induced optic neuropathy (rion) is a severe ocular complication in patients with nasopharyngeal carcinoma (npc) following external beam radiation therapy. however, the systemic risk factors for this condition remain unclear. therefore, patients with npc who received radiotherapy between 2004 and 2007 at the sun yat-sen university cancer center were retrospectively reviewed in this case-control study. the study included 40 rion patients and 40 patients in the control group, who were str ... | 2016 | 27123298 |
| serum immunoglobulin a (iga) level is a potential biomarker indicating cirrhosis during chronic hepatitis b infection. | background. serum immunoglobulins (igs) are frequently elevated in patients with chronic liver disease, but currently there is a lack of sufficient data on serum igs in patients with chronic hepatitis b virus (chb) infection. this study aimed to evaluate serum iga, igg, and igm levels in patients with hbv-related cirrhosis and to analyze, if altered, immunoglobulin levels that were associated with cirrhosis progress. methods. a cohort of 174 chb patients including 104 with cirrhosis (32 decompen ... | 2016 | 27123003 |
| effects of interactions between environmental factors and kif1b genetic variants on the risk of hepatocellular carcinoma in a chinese cohort. | to examine the effect of the potential interaction between kif1b variants (rs17401966 and rs3748578) and environmental factors on the risk of hepatocellular carcinoma (hcc) in a high-risk region in china. | 2016 | 27122668 |
| association between interleukin-21 gene polymorphisms (rs12508721) and hbv-related hepatocellular carcinoma. | interleukin-21 (il-21), as a multifunctional cytokine, plays an important role in many diseases, such as cancer, inflammatory and autoimmune diseases. we aimed to investigate the relationship between polymorphisms of il-21 gene and susceptibility of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) in a chinese population. studied subjects were divided into three groups: 100 patients with hbv-related hcc, 115 patients with chronic hbv infection and 127 healthy controls. genomic dna ... | 2016 | 27122304 |
| systematic review with network meta-analysis: comparative efficacy of oral nucleos(t)ide analogues for the prevention of chemotherapy-induced hepatitis b virus reactivation. | currently, no consensus exists regarding the optimal oral prophylactic regimens for hepatitis b surface antigen seropositive patients undergoing chemotherapy. we aimed to compare the efficacy of oral nucleos(t)ide analogues (nas), including lamivudine, entecavir, adefovir, telbivudine and tenofovir, for the prevention of chemotherapy-induced hepatitis b virus (hbv) reactivation and its related morbidity and mortality in patients with chronic hbv (chb) infection. | 2016 | 27121321 |
| hepatitis b virus x protein amplifies tgf-β promotion on hcc motility through down-regulating ppm1a. | over-activation of transforming growth factor-β (tgf-β) signaling pathway promotes cell migration and invasion in hepatocellular carcinoma (hcc). the hepatitis b virus x protein (hbx) is involved in the enhancement of tgf-β signaling pathway in hcc while the mechanism remains unclear. protein phosphatase magnesium dependent 1a (ppm1a) functions as a phosphatase essential for terminating the tgf-β signaling pathway by dephosphorylating p-smad2/3. in this study, we found that hbx dose-dependently ... | 2016 | 27121309 |
| hepatitis b virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis b surface antigen. | the hepatitis b virus (hbv) has been described as stealth virus subverting immune responses initially upon infection. impaired toll-like receptor signaling by the hbv surface antigen (hbsag) attenuates immune responses to facilitate chronic infection. this implies that hbv replication may trigger host innate immune responses in the absence of hbsag. here we tested this hypothesis, using highly replicative transgenic mouse models. an hbv replication-dependent expression of antiviral genes was exc ... | 2016 | 27121087 |
| comparative study on liver transplantation with and without hepatocellular carcinoma with cirrhosis: analysis of meld, waiting time and survival. | liver transplantation is the usual treatment for hepatocellular carcinoma. | 2016 | 27120734 |
| mutational analysis of hepatitis b virus pre-s1 (9-24) fusogenic peptide. | a hollow nanoparticle known as a bio-nanocapsule (bnc) consisting of hepatitis b virus (hbv) envelope l protein and liposome (lp) can encapsulate drugs and genes and thereby deliver them in vitro and in vivo to human hepatic tissues, specifically by utilizing the hbv-derived infection machinery. recently, we identified a low ph-dependent fusogenic domain at the n-terminal part of the pre-s1 region of the hbv l protein (amino acid residues 9 to 24; nplgffpdhqldpafg), which shows membrane destabil ... | 2016 | 27120459 |
| controversy and strategies exploration in blocking mother-to-child transmission of hepatitis b. | hepatitis b, a serious infectious disease caused by the hepatitis b virus (hbv), remains a worldwide social and public health problem. hepatitis b has a particularly high incidence rate in the world, whereas approximately 35-50% hbv carriers are infected through vertical transmission. even after newborn immunoprophylaxis, vertical transmission still accounts for 5-10% in china according to plenty of literature in chinese language. for these reasons, it is important to determine how to effectivel ... | 2016 | 27119534 |
| cost-effectiveness analysis of antiviral therapy in patients with advanced hepatitis b virus-related hepatocellular carcinoma treated with sorafenib. | antiviral therapy has been demonstrated to significantly improve the survival in patients with advanced hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc). the aim of the study was to investigate the cost-effectiveness of antiviral therapy in patients with advanced hbv-related hcc treated with sorafenib. | 2016 | 27118432 |
| safety of immune checkpoint inhibitors in chinese patients with melanoma. | this study aimed to determine the tolerability of chinese melanoma patients, particularly those with hepatitis b virus (hbv) infection, to immune checkpoint inhibitor therapy. patients with metastatic melanoma who received anti-cytotoxic t lymphocyte-associated antigen-4 antibody (ipilimumab) or anti-programmed death 1 antibody (pembrolizumab) therapy at our hospital between august 2012 and july 2015 were retrospectively reviewed. adverse events were evaluated according to the national cancer in ... | 2016 | 27116334 |
| epidemiology of hepatocellular carcinoma in the asia-pacific region. | hepatocellular carcinoma (hcc) is the predominant primary liver cancer in many countries and is the third most common cause of cancer-related death in the asia-pacific region. the incidence of hcc is higher in men and in those over 40 years old. in the asia-pacific region, chronic hepatitis b virus and hepatitis c virus infections are the main etiological agents; in particular, chronic hepatitis b infection (chb) is still the major cause in all asia-pacific countries except for japan. over the p ... | 2016 | 27114433 |
| maternal hepatitis b virus carrier status and pregnancy outcomes: a prospective cohort study. | infection with hepatitis b virus (hbv) in pregnant women may be a threat for both mothers and fetuses. this study was performed to explore the impact of maternal hbv carrier status on pregnancy outcomes. | 2016 | 27113723 |
| the immunogenicity in healthy infants and efficiency to prevent mother to child transmission of hepatitis b virus of a 10μg recombinant yeast-derived hepatitis b vaccine (hep-ksc). | to evaluate immunogenicity and efficacy of a 10μg recombinant saccharomyces cerevisiae-derived hepatitis b vaccine (kangtai biological products co. ltd, shenzhen, china) (hep-ksc) in newborns. | 2016 | 27113166 |
| association of plasma levels of vitamin d with chronic hepatitis b infection. | 2016 | 27110263 | |
| expression of microrna-155 is downregulated in peripheral blood mononuclear cells of chronic hepatitis b patients. | persistent hepatitis b virus (hbv) infection is sustained by inadequate immune responses, either natural or acquired. recent studies have suggested that immune responses to viral infection may be affected by microrna (mir)-155, via its involvement in immune cell differentiation and maturation. however, little is known on the specific interaction between mir-155 and hbv in host antiviral immunity. | 2016 | 27110261 |
| hepatitis viruses b and d and human immunodeficiency virus infections in hemodialysis patients in the south of iran: prevalence and genotypes. | hepatitis b virus (hbv), hepatitis d virus (hdv), and human immunodeficiency virus (hiv) are transmitted by blood transfusion. thus, hemodialysis (hd) patients are more prone to become the carriers of these infections due to their treatment demands. | 2016 | 27110260 |
| hepatitis d virus infection among hepatitis b surface antigen carriers and in "isolated anti-hbc" antibodies profile in central tunisia. | hepatitis d virus (hdv) causes accelerated liver diseases in patients with hepatitis b virus (hbv) infection. there is lack of data about its prevalence, related risk factors and interaction with hbv carriers in our country. | 2016 | 27110257 |
| simple models based on gamma-glutamyl transpeptidase and platelets for predicting survival in hepatitis b-associated hepatocellular carcinoma. | several hepatic cirrhosis-derived noninvasive models have been developed to predict the incidence and outcomes of hepatocellular carcinoma (hcc). we aimed to investigate the prognostic significance of the two novel established cirrhosis-associated models based on gamma-glutamyl transpeptidase (ggt) and platelets in hepatitis b-associated hcc. | 2016 | 27110127 |
| hydrodynamic injection as a method of gene delivery in mice: a model of chronic hepatitis b virus infection. | gene delivery methods are important for both therapeutic intervention and as tools in research to address specific questions. hydrodynamic injection (hdi) is a method that facilitates the delivery and expression of genetic material in target cells, namely hepatocytes, through an intravenous injection. hdi has great utility for research involving cell death and signaling pathways essential in the processes of cancer, inflammation, and transplant therapy, as well as representing a valuable techniq ... | 2016 | 27108435 |
| a historical perspective on the discovery and elucidation of the hepatitis b virus. | the discovery in 1965 of the "australia antigen," subsequently identified as the hepatitis b virus surface antigen (hbsag), was such a watershed event in virology that it is often thought to mark the beginning of hepatitis research, but it is more accurately seen as a critical breakthrough in a long effort to understand the pathogenesis of infectious hepatitis. a century earlier, virchow provided an authoritative explanation of "catarrhal jaundice," which did not consider an infectious etiology, ... | 2016 | 27107897 |
| hepatitis b virus related cryoglobulinemic vasculitis: a multicentre open label study from the gruppo italiano di studio delle crioglobulinemie - gisc. | cryoglobulinemic vasculitis (cv) related to hepatitis-b virus (hbv) is rare and its treatment is ill-defined. | 2016 | 27106525 |
| proteasomes regulate hepatitis b virus replication by degradation of viral core-related proteins in a two-step manner. | the cellular proteasomes presumably inhibit the replication of hepatitis b virus (hbv) due to degradation of the viral core protein (hbcag). common proteasome inhibitors, however, either enhance or inhibit hbv replication. in this study, the exact degradation process of hbcag and its influences on hbv replication were further studied using bioinformatic analysis, protease digestion assays of recombinant hbcag, and proteasome inhibitor treatments of hbv-producing cell line hepg2.2.15. besides hbc ... | 2016 | 27105855 |
| changes of hbv dna after chemoembolization for hepatocellular carcinoma and the efficacy of antiviral treatment. | unlike systemic chemotherapy for hematological malignancies with hepatitis b virus (hbv) infection, transarterial chemoembolization (tace) for hbv-related hepatocellular carcinoma (hcc) has only recently been reported to cause hbv reactivation and subsequent hepatitis. most patients with hbv-related hcc have an underlying disease with liver fibrosis or cirrhosis, and tace may potentially induce hbv reactivation and liver decompensation. currently, there are no clinical guidelines for managing ta ... | 2016 | 27105647 |
| immunogenicity and immunization costs of adjuvanted versus non-adjuvanted hepatitis b vaccine in chronic kidney disease patients. | hepatitis b virus (hbv) vaccination is recommended for all susceptible chronic pre-hemodialysis and hemodialysis patients. this study assessed the immunogenicity of hbv vaccines (adjuvanted and non-adjuvanted) in chronic kidney disease patients vaccinated at the hospital clinic of barcelona (spain) between january 2007 and july 2012. in addition, the costs for the health system were evaluated accor-ding to the proportion of vaccine responders after receiving either vaccine. patients receiving 3 ... | 2016 | 27105182 |
| locked nucleic acid couples with fok i nucleases to target and cleave hepatitis b virus's gene in vitro. | hepatitis b virus (hbv) is a dented double-stranded dna virus. after infecting human hepatic cells, it forms cccdna that replicates persistently and integrates randomly into the host’s genome during the process of reserve transcription. on average, in each cell with chronic hbv infection, there are about 33 copies of cccdna with a half of 35-57 days, which can be difficult to eradicate. a new strategy is to inhibit hbv transcription by using locked nucleic acid (lna). besides, cleaving hbv genom ... | 2016 | 27103458 |
| combination therapies in the management of large (≥ 5 cm) hepatocellular carcinoma: microwave ablation immediately followed by transarterial chemoembolization. | to evaluate the safety and efficacy of microwave (mw) ablation combined with transarterial chemoembolization in a single stage for the treatment of large (≥ 5 cm) hepatocellular carcinoma (hcc). | 2016 | 27103146 |
| building effective quality improvement programs for liver disease: a systematic review of quality improvement initiatives. | quality indicators are the measurable components of clinical standards. data are limited about the design and impact of interventions to improve quality indicators for patients with chronic liver disease. | 2016 | 27103114 |