Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| manipulation of the host cell membrane by human γ-herpesviruses ebv and kshv for pathogenesis. | the cell membrane regulates many physiological processes including cellular communication, homing and metabolism. it is therefore not surprising that the composition of the host cell membrane is manipulated by intracellular pathogens. among these, the human oncogenic herpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) exploit the host cell membrane to avoid immune surveillance and promote viral replication. accumulating evidence has shown that both ebv and k ... | 2016 | 27624182 |
| epstein-barr viral mirnas inhibit antiviral cd4+ t cell responses targeting il-12 and peptide processing. | epstein-barr virus (ebv) is a tumor virus that establishes lifelong infection in most of humanity, despite eliciting strong and stable virus-specific immune responses. ebv encodes at least 44 mirnas, most of them with unknown function. here, we show that multiple ebv mirnas modulate immune recognition of recently infected primary b cells, ebv's natural target cells. ebv mirnas collectively and specifically suppress release of proinflammatory cytokines such as il-12, repress differentiation of na ... | 2016 | 27621419 |
| puzzling and ambivalent roles of malarial infections in cancer development and progression. | scientific evidence strongly suggests that parasites are directly or indirectly associated with carcinogenesis in humans. however, studies have also indicated that parasites or their products might confer resistance to tumour growth. plasmodium protozoa, the causative agents of malaria, exemplify the ambivalent link between parasites and cancer. positive relationships between malaria and virus-associated cancers are relatively well-documented; for example, malaria can reactivate the epstein-barr ... | 2016 | 27618883 |
| presence of human papillomavirus and epstein-barr virus in squamous lesions of the tongue. | several studies have suggested a possible role of human papillomavirus and epstein-barr virus in the pathogenesis of oral premalignant lesions. this study aimed to investigate the correlation between squamous dysplasia of the tongue and expression of p16 and ki67 immunohistochemically as well as human papillomavirus genotypes with real-time polymerase chain reaction (pcr). | 2016 | 27617701 |
| clonal lymphoproliferations in a patient with common variable immunodeficiency. | common variable immunodeficiency (cvid) comprises a heterogeneous group of disorders of humoral immunity, characterized by marked deficiencies in serum immunoglobulins. immune dysregulation causes susceptibility to recurrent bacterial infections, as well as autoimmune and lymphoproliferative disorders. although the lymphoid cells comprising the atypical proliferations are often clonally related, their malignant potential and clinical significance differ from similar lesions in individuals with i ... | 2016 | 27614471 |
| peg-aspargase and dep regimen combination therapy for refractory epstein-barr virus-associated hemophagocytic lymphohistiocytosis. | epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) is the most frequent subtype of secondary hlh triggered by infections. previous studies have shown that ~30 % or more of patients with ebv-hlh do not respond to standard therapy. this study investigated the efficacy and safety profile of a modified dep regimen in combination with peg-aspargase (l-dep) as a salvage therapy for refractory ebv-hlh. | 2016 | 27613189 |
| primary rare anaplastic large cell lymphoma, alk positive in small intestine: case report and review of the literature. | primary anaplastic large cell lymphoma, alk positive in small intestine is clinically rare and the clinical, radiological and pathological information are generally not available. here, we report a case of 32-year-old male with alk positive anaplastic large cell lymphoma at the junction of jejunum and ileum, and highlight the clinicopathological features and the differential diagnosis of this type lymphoma. | 2016 | 27612448 |
| profile of exosomal and intracellular microrna in gamma-herpesvirus-infected lymphoma cell lines. | exosomes are small vesicles released from cells, into which micrornas (mirna) are specifically sorted and accumulated. two gamma-herpesviruses, kaposi sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv), encode mirnas in their genomes and express virus-encoded mirnas in cells and exosomes. however, there is little information about the detailed distribution of virus-encoded mirnas in cells and exosomes. in this study, we thus identified virus- and host-encoded mirnas in exosomes r ... | 2016 | 27611973 |
| prophylactic and therapeutic adenoviral vector-based multivirus-specific t-cell immunotherapy for transplant patients. | viral infections including cytomegalovirus, epstein-barr virus, adenovirus, and bk virus are a common and predictable problem in transplant recipients. while cellular immune therapies have been successfully used to tackle infectious complications in transplant recipients, manufacturing immunotherapies to address the multitude of possible pathogens can be technically challenging and labor-intensive. here we describe a novel adenoviral antigen presentation platform (ad-mvp) as a tool for rapid gen ... | 2016 | 27606351 |
| clinical and pathological aspects of human immunodeficiency virus-associated plasmablastic lymphoma: analysis of 24 cases. | plasmablastic lymphoma (pbl) is a rare aids-related malignancy with a poor prognosis. little is known about this entity, and no standard treatment regimen has been defined. to establish an adequate treatment strategy, we investigated 24 cases of pbl arising in human immunodeficiency virus-positive individuals. most of the patients were in the aids stage, with a median cd4 count of 67.5/µl. lymph nodes (58 %), gastrointestinal tract (42 %), bone marrow (39 %), oral cavity (38 %), and cns (18 %) w ... | 2016 | 27604616 |
| analysis of epstein barr virus encoded rna expression in nasopharyngeal carcinoma in north-eastern india: a chromogenic in situ hybridization based study. | nasopharyngeal carcinoma (npc) is a common cancer in the north-east region of india. though the role of environmental contributors of npc in the north-eastern part of india is firmly established, ebv as an etiological agent in the region remains unexplored. | 2016 | 27602338 |
| primary splenic b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma: a case report. | b-cell lymphoma (bcl), unclassifiable, with features intermediate between diffuse large bcl (dlbcl) and classical hodgkin's lymphoma (chl), is a novel entity to the world health organization classification system. these tumors are rare aggressive lymphomas that have a poor prognosis. the present study reports the case of a patient with one such lymphoma that occurred in the spleen, which expressed cluster of differentiation (cd)20, cd79α, melanoma associated antigen (mutated) 1, bcl6, cd15 and c ... | 2016 | 27602118 |
| anti-cancer effect of quercetin in xenograft models with ebv-associated human gastric carcinoma. | licorice extracts have been widely used in herbal and folk medications. glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). the flavonoids in licorice are known to have strong anti-cancer activities. quercetin, the most abundant flavonoid, has been shown to have anti-ulcer, anti-cancer, antioxidant, and anti-inflammatory properties. lat ... | 2016 | 27681719 |
| xiap deficiency and mefv variants resulting in an autoinflammatory lymphoproliferative syndrome. | a 16-year-old boy of caucasian ethnicity was evaluated for recurrent febrile episodes occurring during most of his life without establishment of any microbial aetiology. during febrile episodes he developed extensive splenomegaly, lymphadenopathy, anaemia, severe abdominal pain and general malaise. lymph node biopsies demonstrated inflammation and sinus histiocytosis but no malignancy or granuloma. the patient underwent seroconversion for epstein-barr virus (ebv) infection during the hospitalisa ... | 2016 | 27681353 |
| denis burkitt: a legacy of global health. | when first described in 1958, burkitt lymphoma was considered by many to be an african curiosity. however, over the next few decades, over 10,000 publications on burkitt lymphoma would influence many facets of oncology research including immunology, molecular genetics, chemotherapy, and viral oncology. at the time of discovery, its distribution in equatorial africa was unique; it was where a child was born and lived, and not what race they were, that conveyed the greatest incidence risk. its ass ... | 2016 | 27681061 |
| extranodal natural killer/t-cell lymphoma, nasal type, with primary manifestation as an upper eyelid swelling. | extranodal natural killer/t-cell lymphoma (enk/tcl) is most often in the nose or the nasopharynx but can present elsewhere. we report a rare case of enk/tcl that presented as swelling of an upper eyelid without ocular involvement. a 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. a biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. treatment with oral ... | 2016 | 27680487 |
| [mr-imaging findings in epstein-barr virus encephalitis]. | 2016 | 27677103 | |
| lymphomatoid granulomatosis associated with azathioprine use for immune-mediated neuropathy. | lymphomatoid granulomatosis (lg) is a rare epstein-barr virus-driven lymphoproliferative disorder that generally arises in immunosuppressed patients and which can be life-threatening. here we describe the development of pulmonary lg in a patient on long-term azathioprine for immune-mediated neuropathy. although azathioprine carries a boxed warning for malignancy, its association specifically with lg, an otherwise rare entity, is poorly recognised. early recognition of drug-induced lg is critical ... | 2016 | 27671987 |
| serum b-cell activating factor predicts prognosis in nasal type, extranodal nk/t cell lymphoma. | b-cell activating factor (baff) plays important roles in a variety of lymphoid malignancies. compared with healthy adults, patients with non-hodgkin lymphoma had higher level of serum baff, and it corresponded with disease severity, response for therapy and clinical outcome. latent membrane protein 1 (lmp1) encoded by epstein-barr virus (ebv) which is a known agent of nasal, extranodal nk/t cell lymphoma (enktcl) can switch the baff activating promoter leading to higher expression of baff in ebv ... | 2016 | 27668971 |
| negative interaction between smoking and ebv in the risk of multiple sclerosis: the envims study. | results from previous studies on a possible interaction between smoking and epstein-barr virus (ebv) in the risk of multiple sclerosis (ms) are conflicting. | 2016 | 27663872 |
| fluoro analogs of bioactive oxy-sterols: synthesis of an ebi2 agonist with enhanced metabolic stability. | synthesis of several 7-hydroxy oxysterols and their potential roles as signaling molecules in the innate and adaptive immune responses is discussed. discovery of a new, fluorinated, synthetic analog of the 7α,25-dihydroxycholesterol-the endogenous ligand of gpr 183 (ebi2), a g-protein coupled receptor highly expressed upon epstein-barr virus infection is described. fluoro oxysterol 12 showed good metabolic stability while maintaining excellent ebi2 agonist activity. | 2016 | 27658369 |
| expression and methylation data from sle patient and healthy control blood samples subdivided with respect to arid3a levels. | previously published studies revealed that variation in expression of the dna-binding protein arid3a in b lymphocytes from patients with systemic lupus erythematosus (sle) correlated with levels of disease activity ("disease activity in systemic lupus erythematosus correlates with expression of the transcription factor at-rich-interactive domain 3a" (j.m. ward, k. rose, c. montgomery, i. adrianto, j.a. james, j.t. merrill et al., 2014) [1]). the data presented here compare dna methylation patter ... | 2016 | 27656675 |
| epstein-barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse. | epstein-barr virus (ebv) establishes a lifelong latent infection in b lymphocytes and often is found in epithelial cells. several lines of evidence indicate that viral transmission mediated by cell-to-cell contact is the dominant mode of infection by ebv for epithelial cells. however, its detailed molecular mechanism has not been fully elucidated. we investigated the role of host membrane trafficking machinery in this process. we have found that adhesion molecules critical for this process are e ... | 2016 | 27655016 |
| viral il-10 down-regulates the "mhc-i antigen processing operon" through the nf-κb signaling pathway in nasopharyngeal carcinoma cells. | the hla-i antigen processing machinery (apm) plays a crucial role in the anticancer immune response. the loss of surface expression of hla-i molecules is particularly important as this enables tumor cells to evade recognition and lysis by cytotoxic t-lymphocytes. transcriptional control of the apm genes is regulated by the nuclear factor kappa b (nf-κb). bcrfl is an epstein-barr virus homologue of human il-10 (hil-10) and is known as viral il-10 (vil-10). vil-10 shares many immunosuppressive eff ... | 2016 | 27650182 |
| primary cardiac diffuse large b-cell lymphoma in immunocompetent patients: clinical, histologic, immunophenotypic, and genotypic features of 3 cases. | primary cardiac lymphoma (pcl) is a rare extranodal lymphoma that involves only the heart and/or pericardium. primary cardiac lymphoma is much less common in immunocompetent patients compared with those who are immunosuppressed. patients with pcl have variable clinical manifestations that may lead to misdiagnosis and delay in treatment. modern radiologic imaging now allows for earlier detection of these tumors. this study describes the clinical, histologic/cytologic, immunophenotypic, and molecu ... | 2016 | 27649953 |
| infection-related death among persons with refractory juvenile idiopathic arthritis. | severe infections are emerging as major risk factors for death among children with juvenile idiopathic arthritis (jia). in particular, children with refractory jia treated with long-term, multiple, and often combined immunosuppressive and antiinflammatory agents, including the new biological disease-modifying antirheumatic drugs (dmards), are at increased risk for severe infections and death. we investigated 4 persons with jia who died during 1994-2013, three of overwhelming central venous cathe ... | 2016 | 27648582 |
| inflammation-related dna damage and cancer stem cell markers in nasopharyngeal carcinoma. | nitrative and oxidative dna damage plays an important role in inflammation-related carcinogenesis. to investigate the involvement of stem cells in epstein-barr virus infection-related nasopharyngeal carcinoma (npc), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (cd44v6, cd24, and aldh1a1) in npc tissues and npc cell lines. we also measured 8-nitroguanine formation as an indicator of inflammation-related dna lesions. the staining intensity of 8- ... | 2016 | 27647953 |
| [clinicopathologic features of non-keratinizing carcinoma of nasal cavity and paranasal sinus]. | to study the clinicopathologic features, immunophenotype, differential diagnosis and prognosis of non-keratinizing carcinoma of nasal cavity and paranasal sinus. | 2016 | 27646894 |
| cd20 therapies in multiple sclerosis and experimental autoimmune encephalomyelitis - targeting t or b cells? | ms is widely considered to be a t cell-mediated disease although t cell immunotherapy has consistently failed, demonstrating distinct differences with experimental autoimmune encephalomyelitis (eae), an animal model of ms in which t cell therapies are effective. accumulating evidence has highlighted that b cells also play key role in ms pathogenesis. the high frequency of oligoclonal antibodies in the csf, the localization of immunoglobulin in brain lesions and pathogenicity of antibodies origin ... | 2016 | 27645355 |
| neutrophil-to-lymphocyte ratio as a prognostic marker in locally advanced nasopharyngeal carcinoma: a pooled analysis of two randomised controlled trials. | to assess the prognostic value of neutrophil-to-lymphocyte ratio (nlr) in patients with international union against cancer (uicc)-staged iii/iva,b nasopharyngeal carcinoma (npc), who were enrolled into two randomised controlled trials of concurrent/adjuvant chemotherapy when added to radiotherapy (sqnp01), and induction chemotherapy when added to chemoradiotherapy (ncc0901). | 2016 | 27640138 |
| retrospective analysis of oncogenic human papilloma virus and epstein-barr virus prevalence in turkish nasopharyngeal cancer patients. | nasopharyngeal carcinoma (npc) is associated with the epstein-barr virus (ebv). human papilloma virus (hpv) has also been detected in npc cases. in this retrospective study, we analyze the frequency of ebv and hpv infection in 82 turkish patients with npc. a total of 82 were evaluated for ebv and hpv. in situ hybridization (ish) was performed for ebv. hpv-ish and p16 immunohistochemistry used to determine the hpv status. seventy-two of the 82 (87%) npc patients were ebv-positive. the highest rat ... | 2016 | 27640103 |
| large retropharyngeal abscess: a case of mistaken identity. | we report an unusual case of nasopharyngeal carcinoma (npc), presenting initially as a retropharyngeal collection. we discuss the investigation, diagnosis and management of npc and furthermore review the literature of npc, emphasising the varied presentation. a 44-year-old caucasian male ex-smoker presented with a 10-day history of a painless left-sided neck lump; progressive dysphagia and unintentional weight loss. examination demonstrated a large left posterior pharyngeal swelling with soft pa ... | 2016 | 27637277 |
| geographic population structure in epstein-barr virus revealed by comparative genomics. | epstein-barr virus (ebv) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. we sequenced 27 complete ebv genomes from a cohort of multiple sclerosis (ms) patients and healthy controls from italy, although no variants showed a statistically significant association with ms. taking advantage of the availability of ∼130 ebv genomes with known geographical origins, we reveal a striking geographic distribution of ebv sub-pop ... | 2016 | 27635051 |
| elevated level of interleukin-35 in colorectal cancer induces conversion of t cells into itr35 by activating stat1/stat3. | il-35 is a novel heterodimeric and inhibitory cytokine, composed of interleukin-12 subunit alpha (p35) and epstein-barr virus -induced gene 3 (ebi3). il-35 has been reported to be produced by a range of cell types, especially regulatory t cells, and to exert immunosuppressive effects via the statx signaling pathway. in this study, we demonstrated that il-35 expression was elevated in both serum and tumors in patients with colorectal cancer. il-35 mainly expressed in cd4+ t cells in human colorec ... | 2016 | 27682874 |
| recent insights in the pathogenesis of post-transplantation lymphoproliferative disorders. | post-transplant lymphoproliferative disorder (ptld) is an aggressive complication of solid organ and hematopoietic stem cell transplantation that arises in up to 20% of transplant recipients. infection or reactivation of the epstein-barr virus (ebv), a ubiquitous human herpesvirus, in combination with chronic immunosuppression are considered as the main predisposing factors, however insight in ptld biology is fragmentary. the study of ptld is complicated by its morphological heterogeneity and th ... | 2016 | 27683629 |
| erk/c-jun recruits tet1 to induce zta expression and epstein-barr virus reactivation through dna demethylation. | dna demethylation plays an essential role in the reactivation of epstein-barr virus (ebv) from latency infection. however, it is unclear how epigenetic modification is initiated in responding to stimuli. here, we demonstrate that erk/c-jun signaling is involved in dna demethylation of ebv immediate early (ie) gene zta in response to 12-o-tetradecanoylphorbol-13-acetate (tpa) stimulation. remarkably, ser73 phosphorylation of c-jun facilitates zta promoter demethylation and ebv reactivation, where ... | 2016 | 27708396 |
| identification of genes involved in epstein-barr virus-associated nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is the most common cancer originating from the nasopharynx, and can be induced by infection with epstein-barr virus (ebv). to study the mechanisms of ebv-associated npc, a microarray of the gse12452 dataset was analyzed. gse12452 was downloaded from gene expression omnibus and consisted of 31 npc samples and 10 normal healthy nasopharyngeal tissue samples. the differentially-expressed genes (degs) were screened using the linear models for microarray data package in ... | 2016 | 27698802 |
| dynamics of epstein-barr viral load after hematopoietic stem cell transplantation and effect of preemptive rituximab therapy. | epstein-barr virus (ebv) displays oncogenic properties, particularly in the immunocompromised host. notably, hematopoietic stem cell transplantation (hsct) recipients with a detectable blood ebv viral load (bebvl) are considered at higher risk of post-transplant lymphoproliferative diseases (ptld). therefore, bebvl is monitored after hsct, and preemptive rituximab may be used in patients with high values. however, little is known about post-hsct bebvl dynamics, and the threshold that should lead ... | 2016 | 27696681 |
| diagnostic dilemma: epstein-barr virus (ebv) infectious mononucleosis with lung involvement or co-infection with legionnaire's disease? | hospitalized adults with fever and "pneumonia" can be a difficult diagnostic challenge particularly when the clinical findings may be due to different infectious diseases. | 2016 | 27712834 |
| circulating epstein-barr virus-encoded micro-rnas as potential biomarkers for nasal natural killer/t-cell lymphoma. | nasal natural killer/t-cell lymphoma (nnktl) is an epstein-barr virus (ebv)-associated malignancy and is characterized by local invasion and widespread dissemination, with a consequent poor prognosis. micro-rnas (mirnas) play roles in the pathogenesis of several malignancies by regulating gene expression and have been recently identified as stable entities in serum. here, we investigated the value of circulating ebv-mirnas as biomarkers for nnktl. sera of patients with nnktl were subjected to mi ... | 2016 | 27709652 |
| concordance of immune checkpoints within tumor immune contexture and their prognostic significance in gastric cancer. | checkpoint blockade therapy has emerged as a novel approach for cancer immunotherapy in several malignancies. however, patient prognosis and disease progression relevant to immune checkpoints in gastric tumor microenvironment are not defined. this study aims to investigate the expression and prognostic significance of immune checkpoints within gastric cancer. in the study, a cohort of 398 cancer tissues from stage i to iv gastric cancer patients were assessed for programmed cell death 1 ligand 1 ... | 2016 | 27720576 |
| [clinical features and outcomes: analysis of 9 cases of hiv-negtive plasmablastic lymphoma]. | objective: to evaluate the clinical features and outcomes of hiv-negtive plasmablastic lymphoma (pbl). methods: nine patients with hiv-negtive pbl were diagnosed and treated between january 2006 and january 2016. the clinical and follow-up data were analyzed retrospectively. results: the median age was 56 years (range 30-77 years) with a male-to-female ratio of 2∶1. nobody had underlying diseases associated with immunosuppression. primary extra nodal diseases were observed in 7 cases and only 1 ... | 2016 | 27719718 |
| cd56(-) extranodal natural killer (nk)/t-cell lymphoma, nasal type presenting as skin ulcers in a white man. | 2016 | 27752533 | |
| [panuveitis with oral and genital ulcer misdiagnosed as behcet's disease: two cases report and literature review]. | here we reported two patients who presented with panuveitis and were transferred from ophthalmologists to rheumatologists, for both the patients had oral and genital ulcers. they were misdiagnosed with behcet's disease at first glance. two young males presented with acute uveitis with history of recurrent oral and genital ulcers. they initially presented with symptoms and signs resembling behcet's disease and were treated with systemic steroids with suboptimal responses. routine laboratory test ... | 2016 | 27752180 |
| fatal outcome of an epstein-barr virus positive mucocutaneous ulcer secondary to methotrexate. | 2016 | 27734625 | |
| the immunobiology of interleukin-35 and its regulation and gene expression. | interleukin-35 (il-35) is the latest addition to the il-12 family of heterodimeric cytokines, consisting of il-12 p35 subunit and il-27β subunit epstein-barr virus induced 3 (ebi3). since its discovery, il-35 has been shown to exhibit immunosuppressive activities which are distinct from other members of il-12 family. il-35 is also unique in that it is expressed primarily by regulatory t-cells (tregs) rather than by antigen-presenting cells (apcs). il-35 can directly suppress effector t-cell prol ... | 2016 | 27734415 |
| distinct expression profile of key molecules in crawling-type early gastric carcinoma. | gastric "crawling-type" adenocarcinoma (cra) is a tumor histologically characterized by irregularly fused glands with low-grade cellular atypia that tends to spread laterally in the mucosa. to date, the expression characteristics of the key molecules involved in cra, including receptor tyrosine kinases (rtks), mismatch repair (mmr) proteins, phosphatase and tensin homolog (pten), as well as the epstein-barr virus (ebv) status, have yet to be uncovered. | 2016 | 27734272 |
| cellular models for mitochondrial dna-based diseases: lymphoblastoid cell lines and transmitochondrial cybrids. | mitochondrial dna (mtdna) mutations cause a variety of mitochondrial dna-based diseases which have been studied using lymphoblastoid cell lines (lcls) and transmitochondrial cybrids. individual genetic information is preserved permanently in lcls while the development of transmitochondrial cybrids provide ex-vivo cellular platform to study molecular mechanism of mitochondrial dna-based diseases. the cytoplasmic donor cells for previous transmitochondrial cybrids come from patient's tissue or pla ... | 2016 | 27733340 |
| tofacitinib induces g1 cell-cycle arrest and inhibits tumor growth in epstein-barr virus-associated t and natural killer cell lymphoma cells. | epstein-barr virus (ebv) infects not only b cells, but also t cells and natural killer (nk) cells, and is associated with t or nk cell lymphoma. these lymphoid malignancies are refractory to conventional chemotherapy. we examined the activation of the jak3/stat5 pathway in ebv-positive and -negative b, t and nk cell lines and in cell samples from patients with ebv-associated t cell lymphoma. we then evaluated the antitumor effects of the selective jak3 inhibitor, tofacitinib, against these cell ... | 2016 | 27732937 |
| mutational analysis of extranodal nk/t-cell lymphoma using targeted sequencing with a comprehensive cancer panel. | extranodal natural killer (nk)/t-cell lymphoma, nasal type (nktcl), is a malignant disorder of cytotoxic lymphocytes of nk or t cells. it is an aggressive neoplasm with a very poor prognosis. although extranodal nktcl reportedly has a strong association with epstein-barr virus, the molecular pathogenesis of nktcl has been unexplored. the recent technological advancements in next-generation sequencing (ngs) have made dna sequencing cost- and time-effective, with more reliable results. using the i ... | 2016 | 27729836 |
| the increased antibody response to epstein-barr virus in multiple sclerosis is restricted to selected virus proteins. | multiple sclerosis (ms) is associated with epstein-barr virus (ebv) infection, and the antibody response to ebv is reported to be increased in ms. ebv contains multiple antigens, and only a few have been investigated. our hypothesis is that ms patients will have an increased antibody response to only selected ebv antigens. we used immunoprecipitation and quantitative mass spectrometry to identify candidate ebv antigens. we then measured the antibody response to 10 individual ebv proteins with qu ... | 2016 | 27725113 |
| oncogenic γ herpesviruses ebv and hhv8 in kidney transplantation. | epstein-barr virus (ebv) and human herpesvirus-8 (hhv-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. ebv is associated with post-transplantation lymphoproliferative disorder (ptld), with increased risk in ebv-seronegative patients on intensified immunosuppression. human herpesvirus-8 is associated with kaposi's sarcoma (ks), with an increased risk in certain patient populations. diagnosis of ptld and ks relies on tissue biopsy. the mainstay o ... | 2016 | 27772621 |
| head and neck epstein-barr virus mucocutaneous ulcer: case report and literature review. | to report the clinical presentation, treatment, and management outcomes of patients with epstein-barr virus-positive mucocutaneous ulcer (ebvmcu) of the head and neck, which is a newly characterized pathologic entity with aggressive morphology but follows an indolent, self-limiting clinical course. | 2016 | 27113560 |
| hla and risk of diffuse large b cell lymphoma after solid organ transplantation. | solid organ transplant recipients have heightened risk for diffuse large b cell lymphoma (dlbcl). the role of donor-recipient hla mismatch and recipient hla type on dlbcl risk are not well established. | 2016 | 26636741 |
| epstein-barr virus associated with a lymphoma-mimicking lesion of the uterine cervix. | 2016 | 27769038 | |
| receptor tyrosine kinase amplified gastric cancer: clinicopathologic characteristics and proposed screening algorithm. | although targeted therapy for receptor tyrosine kinases (rtks) of advanced gastric cancers (agcs) has been in the spotlight, guidelines for the identification of rtk-amplified gastric cancers (ra-gcs) have not been established. in this study, we investigate clinicopathologic characteristics of ra-gcs and propose a screening algorithm for their identification. we performed immunohistochemistry (ihc) for mlh1, msh2, pms2, msh6, key rtks (egfr, her2, met), and p53, in situ hybridization for epstein ... | 2016 | 27765925 |
| positive regulation of hif-1a expression by ebv oncoprotein lmp1 in nasopharyngeal carcinoma cells. | latent membrane protein 1 (lmp1) is a pivotal viral oncoprotein that contributes to the carcinogenesis of epstein-barr virus (ebv)-associated malignancies, including nasopharyngeal carcinoma (npc). we investigated the regulation of hypoxia-inducible factor 1-α (hif-1α) by lmp1. in npc cells, we found that lmp1 significantly enhanced the hif-1α mrna level, and not only the protein amount as described previously. mechanistically, the stability of the hif-1α transcript was remarkably prolonged by l ... | 2016 | 27567526 |
| recipient-derived ebv-positive monomorphic plasmacytoma type posttransplant lymphoproliferative disorder after allogeneic stem cell transplant for severe aplastic anemia: a case report. | monomorphic plasmacytoma-type posttransplant lymphoproliferative disorder (ptld) has not been reported after pediatric hematopoietic stem cell transplantation. we present a child with hepatitis-associated severe aplastic anemia who underwent an unrelated allogeneic hematopoietic stem cell transplantation and subsequently developed graft failure and an epstein-barr virus-positive monomorphic plasmacytoma-type ptld of recipient origin. despite broad-spectrum antimicrobials, weaning immunosuppressi ... | 2016 | 27403771 |
| [chronic active epstein-barr virus enteritis: report of a case]. | 2016 | 27760621 | |
| karyotypic abnormalities associated with epstein-barr virus status in classical hodgkin lymphoma. | classical hodgkin lymphoma (chl) is morphologically characterized by scattered malignant hodgkin/reed-sternberg (hrs) cells that are far outnumbered by surrounding reactive hematolymphoid cells. approximately half of all cases of chl are associated with infection by epstein-barr virus (ebv), an oncogenic herpesvirus that expresses a number of proteins thought to contribute to transformation. while a small number of published studies have attempted to identify recurrent cytogenetic abnormalities ... | 2016 | 27751359 |
| [plasmablastic lymphoma]. | plasmablastic lymphoma (pbl) is a rare and aggressive subtype of non-hodgkin lymphoma that commonly occurs in human immunodeficiency virus (hiv)-positive individuals, and affects oral sites. occasionally, it has been described in hiv-negative patients and involving non-oral sites. pathologically, pbl is a high-grade b-cell lymphoma that displays the immunophenotype of a terminally differentiated b-lymphocyte with loss of b-cell markers (cd20) and expression of plasma-cell antigens. epstein-barr ... | 2016 | 27576534 |
| programmed death-ligand 1 expression is common in gastric cancer associated with epstein-barr virus or microsatellite instability. | blockade of the programmed death 1 (pd-1) pathway has emerged as a novel therapy for cancer. therefore, development of biomarkers for response prediction, such as pd-ligand 1 (pd-l1) expression by immunohistochemistry, may help to stratify patients. solid tumors with cd8 t-cell rich tumor microenvironment have been implicated to be associated with increased pd-l1 expression. we hypothesized that gastric cancers associated with epstein-barr virus infection (ebv+) or microsatellite instability (ms ... | 2016 | 27465786 |
| interferon-β therapy specifically reduces pathogenic memory b cells in multiple sclerosis patients by inducing a fas-mediated apoptosis. | growing evidences put b lymphocytes on a central stage in multiple sclerosis (ms) immunopathology. while investigating the effects of interferon-β (ifn-β) therapy, one of the most used first-line disease-modifying drugs for the treatment of relapsing-remitting ms, in circulating b-cell sub-populations, we found a specific and marked decrease of cd27(+) memory b cells. interestingly, memory b cells are considered a population with a great disease-driving relevance in ms and resulted to be also ta ... | 2016 | 27265253 |
| acute liver failure: outcome and value of pediatric end-stage liver disease score in pediatric cases. | the aims of this study were to analyze the characteristics of patients with acute liver failure (alf) in our center and evaluate the prognostic value of the pediatric end-stage liver disease (peld) score calculated at admission. | 2016 | 27749626 |
| epstein-barr virus dna level as a novel prognostic factor in nasopharyngeal carcinoma: a meta-analysis. | the plasma epstein-barr virus (ebv) dna level in patients with nasopharyngeal carcinoma (npc) performs as an appealing prognostic factor, but conclusions of its prognostic values from previous studies are inconsistent. in this study, we performed a comprehensive meta-analysis to evaluate the prognostic value of ebv dna level in patients with npc. | 2016 | 27749596 |
| clinicopathological features of 11 epstein-barr virus-associated intrahepatic cholangiocarcinoma at a single center in china. | to date, only 20 cases of epstein-barr virus (ebv)-associated intrahepatic cholangiocarcinomas (ihccs) have been reported in the literature.pathology records of ihcc from january 1, 2007 to december 31, 2013 were retrieved from our hospital. clinical information related to ebv-associated ihcc were also obtained, including gender, age at initial diagnosis, tumor size, tumor-node-metastasis stage, and follow-up duration. surgically resected stage-matched ebv-negative ihccs with full follow-up were ... | 2016 | 27749575 |
| nasopharyngeal carcinoma: understanding its molecular biology at a fine scale. | among all cancers, the incidence of nasopharyngeal carcinoma (npc) is quite high in the endemic regions. npc is a head and neck cancer with poor survival rate, and is rare throughout most of the world but common in certain geographic areas, like southern asia and some regions of north east india (nagaland, manipur, and mizoram). a clear understanding of its etiology is still lacking, but npc is widely suspected to be the result of both genetic susceptibility and exposure to environmental factors ... | 2016 | 27748661 |
| severe epstein-barr virus infection in primary immunodeficiency and the normal host. | epstein-barr virus (ebv) infection is ubiquitous in humans, but the majority of infections have an asymptomatic or self-limiting clinical course. rarely, individuals may develop a pathological ebv infection with a variety of life threatening complications (including haemophagocytosis and malignancy) and others develop asymptomatic chronic ebv viraemia. although an impaired ability to control ebv infection has long been recognised as a hallmark of severe t-cell immunodeficiency, the advent of nex ... | 2016 | 27748521 |
| ubiquitous distribution of epstein-barr virus and the highly uneven distribution of nasopharyngeal carcinoma. | 2016 | 27748347 | |
| the promise of pd-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. pd-l1. | preliminary clinical studies of anti-programmed cell death-1 (anti-pd-1) therapy in gastro-esophageal cancers have suggested promising single-agent activity. in patients who received prior treatment for advanced disease, pembrolizumab has been associated with a response rate of 20% in programmed cell death-1 ligand 1 (pd-l1)-positive tumors, and nivolumab with a response rate of 12% in unselected tumors. both agents yielded a median duration of response lasting ~6-7 months. pd-l1 expression and ... | 2016 | 27747091 |
| post-transplant lymphoproliferative disorder presenting as cd20-negative plasmablastic lymphoma in the lung. | post-transplant lymphoproliferative disorders (ptld) are a serious complication of transplantation with a high mortality. most ptld present within the first year of transplantation and are associated with epstein-barr virus (ebv) infection. plasmablastic lymphoma (pbl) is a rare but aggressive disease originally described in patients with hiv, presenting most commonly in the jaw and oral mucosa. to our knowledge, this is the first case of pbl presenting as ptld of the lung in a hiv and ebv negat ... | 2016 | 27746876 |
| meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical hodgkin lymphoma. | the prognostic significance of tumor-associated macrophages (tam) in adult classical hodgkin lymphoma (chl) remains controversial. here, we report a meta-analysis of the association of cd68 and cd163 infiltration on the clinical outcome of adult chl. | 2016 | 27745550 |
| kidney graft leiomyosarcoma: a case report. | kidney transplant (kt) recipients have a higher incidence of malignancy than the general population. smooth muscle tumors (smt), including leiomyosarcoma, are rare in kidney transplant recipients, and most cases are associated with epstein-barr virus (ebv) infection. | 2016 | 27742302 |
| transgenic mouse models of tumor virus action. | genetically engineered mice (gems) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. this review provides an overview of seminal discoveries made through the use of gem models for human dna tumor viruses. emphasis is placed on the discoveries made in the study of human papillomaviruses, merkel cell carcinoma-associated polyomavirus, epstein-barr virus, and kaposi's ... | 2016 | 27741405 |
| pd-l1 is upregulated by ebv-driven lmp1 through nf-κb pathway and correlates with poor prognosis in natural killer/t-cell lymphoma. | natural killer/t-cell lymphoma (nktcl) is an epstein-barr virus (ebv)-associated, highly aggressive lymphoma. treatment outcome remains sub-optimal, especially for advanced-stage or relapsed diseases. programmed cell death receptor 1 (pd-1) and pd ligand 1 (pd-l1) have become promising therapeutic targets for various malignancies, but their role in the pathogenesis and their interactions with ebv in nktcl remains to be investigated. | 2016 | 27737703 |
| extranodal nk/t cell lymphoma, nasal type (enktl-nt): an update on epidemiology, clinical presentation, and natural history in north american and european cases. | extranodal nk/t cell lymphoma, nasal type (enktl-nt) is an aggressive extranodal non-hodgkin lymphoma most commonly occurring in east asia and latin america but with increasing incidence in the united states. data on epidemiology, disease presentation, and outcome for european and north american ("western") cases are very limited. we review published landmark clinical studies on enktl-nt in the west and report in detail recent data, including our institutional experience. | 2016 | 27778143 |
| a prospective study of alemtuzumab as a second-line agent for steroid-refractory acute graft-versus-host disease in pediatric and young adult allogeneic hematopoietic stem cell transplantation. | we describe a single-center prospective study of alemtuzumab as a second-line agent for steroid-refractory (sr) acute graft-versus-host disease (agvhd) in pediatric and young adult allogeneic hematopoietic stem cell transplant recipients. alemtuzumab was administered for grades ii to iv agvhd if patients did not improve within 5 days or worsened within 48 hours after corticosteroids. interim analyses of alemtuzumab levels and response were performed after every 5 patients enrolled, resulting in ... | 2016 | 27664325 |
| clinical features and treatment outcome of epstein-barr virus-positive nodal t-cell lymphoma. | the classification of mature nk-/t-cell lymphoma mainly originating from the t-cell lineage with predominantly nodal involvement and epstein-barr virus (ebv) positivity in a majority of tumor cells is unresolved. we analyzed the clinical features and treatment outcomes of such patients. five patients with ebv-positive nodal t-cell lymphoma were surveyed during follow-up period. the median age was 53 years (range 33-88 years), and all patients showed nodal involvement. the patients mostly present ... | 2016 | 27456462 |
| a child's hla-drb1 genotype increases maternal risk of systemic lupus erythematosus. | systemic lupus erythematosus (sle) disproportionately affects women of reproductive age. during pregnancy, women are exposed to various sources of fetal material possibly constituting a significant immunologic exposure relevant to the development of sle. the objective of this study was to investigate whether having any children who carry drb1 alleles associated with sle increase the risk of maternal sle. this case-control study is based on the university of california, san francisco mother-child ... | 2016 | 27388144 |
| expression of programmed cell death ligand 1 (pd-l1) in advanced stage ebv-associated extranodal nk/t cell lymphoma is associated with better prognosis. | programmed cell death 1 (pd-1)/pd-1 ligand 1 (pd-l1) pathway blockade has emerged as a promising strategy for cancer therapy. extranodal natural killer/t cell lymphoma (enktl) is an aggressive disease characterized by a strong association with epstein-barr virus (ebv), and chronic ebv infection is known to induce pd-l1 expression. however, the pd-1/pd-l1 pathway status in enktl remains elusive. thus, the expression pattern of pd-1 and pd-l1 was investigated in 73 enktl cases, and its clinicopath ... | 2016 | 27595782 |
| pediatric small bowel transplantation: a single-center experience from turkey. | small bowel transplantation (sbtx) is a treatment option for patients with serious parenteral nutrition-related problems in intestinal failure. izmir tepecik training research hospital organ transplantation center is still the only pediatric intestinal transplant center in turkey. | 2016 | 27782890 |
| epstein-barr virus (ebv)-bamhi-a rightward transcript (bart)-6 and cellular microrna-142 synergistically compromise immune defense of host cells in ebv-positive burkitt lymphoma. | background this study was designed to explore the molecular mechanism underlying the effect of cellular mirnas and ebv mirna upon the expression of targets such as pten, and their involvement in the pathogenesis of burkitt lymphoma. material and methods in this study, we examined several differentially expressed cellular mirnas in ebv-positive versus ebv-negative burkett lymphoma tissue samples, and confirmed pten as targets of cellular mir-142 by using a bioinformatics tool, luciferase reporter ... | 2016 | 27796281 |
| epstein-barr virus micrornas reduce immune surveillance by virus-specific cd8+ t cells. | infection with epstein-barr virus (ebv) affects most humans worldwide and persists life-long in the presence of robust virus-specific t-cell responses. in both immunocompromised and some immunocompetent people, ebv causes several cancers and lymphoproliferative diseases. ebv transforms b cells in vitro and encodes at least 44 micrornas (mirnas), most of which are expressed in ebv-transformed b cells, but their functions are largely unknown. recently, we showed that ebv mirnas inhibit cd4(+) t-ce ... | 2016 | 27698133 |
| reply to the letter to the editor 'epstein-barr virus reactivation in extranodal natural killer/t-cell lymphoma patients: a previously unrecognized serious adverse event in a pilot study with romidepsin, histone deacetylase (hdac) inhibitors when combined with a proteasome inhibitor are safe and effective in patients with extranodal natural killer/t-cell lymphoma' by tan et al. | 2016 | 27502713 | |
| epstein-barr virus-positive diffuse large b-cell lymphoma involving the colon in a patient with ulcerative pancolitis and polymyositis on long-term methotrexate therapy. | the link between immunosuppressive therapy and increased lymphoma risk is well established in patients with solid organ transplantation. epstein-barr virus-positive (ebv) diffuse large b-cell lymphoma (dlbcl) is known to be a complication in patients receiving methotrexate for rheumatoid arthritis, and the risk of lymphoma in inflammatory bowel disease (ibd) has raised concerns regarding the lymphoproliferative potential of immunomodulatory therapy. in this report, we describe a case of ebv-posi ... | 2016 | 27785332 |
| epstein-barr virus-associated acute liver failure present in a 67-year-old immunocompetent female. | acute liver failure (alf) is a rare illness with a high mortality rate. the only favorable management is emergent liver transplantation. about 13% of alf cases have no clear etiology. epstein-barr virus (ebv)-associated alf accounts for less than 1% of all alf cases, and is seen mostly in adults younger than 40 years. there are only a few cases of ebv-associated alf in elderly immunocompromised adults. we report a case of alf in an immunocompetent 67-year-old woman caused by ebv infection that w ... | 2016 | 27785330 |
| [a case of chronic active epstein-barr virus infection with concomitant giant coronary artery aneurysm]. | 2016 | 27784484 | |
| [infection status and prognosis analysis of epstein-barr virus in patients with newly diagnosed hodgkin's lymphoma]. | to investigate the epstein barr virus(ebv) positive rate in newly diagnosed hodgkin's lymphoma(hl) and the prognostic significance of ebv status. | 2016 | 27784366 |
| posttransplant lymphoproliferative disorder manifesting as intestinal epstein-barr virus-positive anaplastic large-cell lymphoma in an adult renal transplant recipient. | posttransplant lymphoproliferative disorder is a relatively common posttransplant malignancy affecting as many as 10% of all solid-organ recipients. most cases of posttransplant lymphoproliferative disorder are of b-cell origin, with common epstein-barr virus association. posttransplant lymphoproliferative disorders of t-cell origin are much rarer and less frequently associated with epstein-barr virus. here, we report an unusual case of epstein-barr virus-positive anaplastic large-cell lymphoma ... | 2016 | 27805515 |
| protein stabilization improves stat3 function in autosomal dominant hyper-ige syndrome. | autosomal dominant hyper-ige syndrome (ad-hies) is caused by dominant-negative mutations in stat3; however, the molecular basis for mutant stat3 allele dysfunction is unclear and treatment remains supportive. we hypothesized that ad-hies mutations decrease stat3 protein stability and that mutant stat3 activity can be improved by agents that increase chaperone protein activity. we used computer modeling to characterize the effect of stat3 mutations on protein stability. we measured stat3 protein ... | 2016 | 27799162 |
| expression of epstein-barr virus among oral potentially malignant disorders and oral squamous cell carcinomas in the south indian tobacco-chewing population. | oral cancer is the sixth most common malignancy in the world. viruses are the causative agents of approximately 10-15% of all cancers worldwide (cancers, 6, 2014 and 2155). the tumorigenic roles of epstein-barr virus in oral cancer are unclear. literature search results are conflicting and dependent on various factors such as geographical/regional variations, sociocultural lifestyles, dietary habits, chewing/smoking tobacco habit. this study is the first original observation about frequency of e ... | 2016 | 27704636 |
| humoral markers of active epstein-barr virus infection associate with anti-extractable nuclear antigen autoantibodies and plasma galectin-3 binding protein in systemic lupus erythematosus. | we investigated if signs of active epstein-barr virus and cytomegalovirus infections associate with certain autoantibodies and a marker of type i interferon activity in patients with systemic lupus erythematosus. igm and igg plasma levels against epstein-barr virus early antigen diffuse and cytomegalovirus pp52 were applied as humoral markers of ongoing/recently active epstein-barr virus and cytomegalovirus infections, respectively. plasma galectin-3 binding protein served as a surrogate marker ... | 2016 | 27084029 |
| second malignant neoplasm following childhood cancer: a nested case-control study of a recent cohort (1987-2004) from the childhood cancer registry of the rhône-alpes region in france. | from a population-based cohort of cases of first cancers diagnosed between 1987 and 2004, before the patient's age of 15 years, the authors conducted a nested case-control study, matching 64 patients who experienced a second malignant neoplasm (smn) with 190 controls. smns comprised 10 leukemia or myelodysplastic syndromes, 5 lymphomas induced by epstein-barr virus after allograft, and 49 solid tumors, including mainly 25 carcinomas (17 of the thyroid), 9 bone sarcomas, and 7 central nervous sys ... | 2016 | 27687523 |
| spontaneous metastases in immunocompetent mice harboring a primary tumor driven by oncogene latent membrane protein 1 from epstein-barr virus. | in vitro and clinical studies suggest that the oncogene lmp1 (latent membrane protein 1) encoded by epstein-barr virus (ebv) plays a role in the development of nasopharyngeal carcinoma (npc) and the formation of metastases in immunocompetent individuals. however, whether lmp1 itself is sufficient to drive these events in immunocompetent hosts remains elusive due to the lack of appropriate experimental models. the aim of this study was to study lmp1-dependent tumorigenesis and metastasis in balb/ ... | 2016 | 27793268 |
| perturbing purinergic signaling: a pathogen's guidebook to counteracting inflammatory responses. | in this issue of the biomedical journal, we learn how bacteria and parasites alike counteract inflammatory signaling by manipulating purinergic signaling. we also focus on an original article shedding light on the role of an epstein-barr virus encoded gene in metastasis in nasopharyngeal carcinoma. finally, we learn about a possible link between trichomonas vaginalis and recurrent urinary tract infection. | 2016 | 27793264 |
| acute pancreatitis associated with everolimus after kidney transplantation: a case report. | acute pancreatitis (ap) following kt is a rare and often fatal complication of the early post-transplant period. common causative factors for ap are rare after kt; anti-rejection drugs as cya, prednisone and mmf have been implicated, although evidence is not strong and we found no reports on possible causative role for mtor inhibitors. | 2016 | 27793122 |
| a case of epstein-barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. | hemophagocytic lymphohistiocytosis (hlh) is a life threatening hematological disorder associated with severe systemic inflammation caused by an uncontrolled and ineffective immune response resulting in cytokine storm. epstein-barr virus (ebv) is the most common infectious agent in patients with the viral-associated hlh. limited numbers of cases with cardiac complication have been demonstrated in other viral-associated hlh patients. herein, we report a pediatric case of severe ebv-associated hlh ... | 2016 | 27793118 |
| lmp1 signaling pathway activates irf4 in latent ebv infection and a positive circuit between pi3k and src is required. | interferon (ifn) regulatory factors (irfs) have crucial roles in immune regulation and oncogenesis. we have recently shown that irf4 is activated through c-src-mediated tyrosine phosphorylation in virus-transformed cells. however, the intracellular signaling pathway triggering src activation of irf4 remains unknown. in this study, we provide evidence that epstein-barr virus (ebv) latent membrane protein 1 (lmp1) promotes irf4 phosphorylation and markedly stimulates irf4 transcriptional activity, ... | 2016 | 27819673 |
| modulation of mir-185-5p expression by ebv-mir-bart6 contributes to developmental differences in abcg4 gene expression in human megakaryocytes. | immune thrombocytopenia (itp) is an acquired autoimmune disorder characterized by low platelet count and bleeding, and is usually triggered by viral infections. we previously reported that 14 viral micrornas of megakaryocytes cultured with serum from patients with itp, including ebv-mir-bart6, are up-regulated. previous research has reported that ebv-mir-bart6 down-regulated the expression of mir-185-5p. we therefore predicted that the abcg4 gene, which is highly expressed in megakaryocyte proge ... | 2016 | 27816548 |
| establishment and characterization of a novel hodgkin lymphoma cell line, am-hlh, carrying the epstein-barr virus genome integrated into the host chromosome. | we describe the establishment and characterization of a cell line, am-hlh, obtained from a patient with epstein-barr virus-positive (ebv(+) ) nodular sclerosis-type hodgkin lymphoma (hl). the cells were positive for cd2 and cd30 and negative for cd15. the immunoglobulin heavy- and κ light-chain genes were rearranged. the karyotype was of the triploid range. southern blotting using the ebv terminal repeat probe detected 3 hybridizing bands that were identical to those of the parental hl material. ... | 2016 | 27813134 |