Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| experimental microbiology of saturated salt solutions and other harsh environments. 3. growth of salt-tolerant penicillium notatum in boron-rich media. | a stress-tolerant strain of penicillium notatum, isolated by passage through a nutrient solution saturated with calcium acetate, was found to have a tolerance to boron in several states of oxidation. growth in the presence of elementary boron, saturating amounts of boric acid, and with various concentrations of sodium borohydride was observed and mycelial mats were spectrographically analyzed for boron accumulation. | 1967 | 6076112 |
| the effect of concentration, time and temperature on the viability of penicillium notatum spores exposed to phenols. | 1967 | 4383695 | |
| carbohydrate metabolism of penicillium chrysogenum spores. i. occurrence of tricarboxylic acid cycle enzymes in cell-free extracts of spores. | 1967 | 4233797 | |
| penicillin acyltransferase in penicillium chrysogenum. | isotopic exchange of (35)s between penicillins and 6-amino-penicillanic acid (6-apa) was observed in cell-free extracts of penicillium chrysogenum. sulfhydryl-containing compounds were required for activity. dithiothreitol, dithioerythritol, mercaptoethanol, and glutathione served as activators. the acyltransferase was purified threefold by adsorption on calcium phosphate gel at ph 6 and elution at ph 8. the partially purified enzyme showed maximal activity at ph 8. the enzyme was stable at 25 c ... | 1967 | 4964480 |
| effect of growth rate on the synthesis of penicillin by penicillium chrysogenum in batch and chemostat cultures. | the kinetics of penicillin production by penicillium chrysogenum wis 54-1255 in a glucose-limited chemostat and in batch cultures are reported. the specific production rate of penicillin, q(pen) (units per milligram of dry weight per hour) was independent of specific growth rate over the range 0.014 to 0.086 hr. growth was stopped by restricting the glucose supply to the "maintenance ration," that is, the glucose requirement of the organism at zero growth rate with all other nutrients in excess. ... | 1967 | 16349736 |
| acylation of 6-aminopenicillanic acid by penicillium chrysogenum. | 1966 | 16349678 | |
| the biosynthesis of biotin in growing yeast cells: the formation of biotin from an early intermediate. | 1. yeast cells grown in the presence of an unknown radioactive biotin vitamer produced by penicillium chrysogenum incorporated the vitamer into the newly synthesized biotin. 2. the biotin was isolated as the avidin-biotin complex and after hydrolysis the biological activity and radioactivity were shown to be coincidental. 3. the specific activity of the biotin was identical with that of the pimelic acid used in a previous investigation to label the unknown vitamer. 4. the role of the unknown bio ... | 1966 | 16742431 |
| an early intermediate in the biosynthesis of biotin: incorporation studies with [1,7-c(2)]pimelic acid. | 1. an unknown biotin vitamer was obtained in high yields in culture filtrates of penicillium chrysogenum. 2. production of this vitamer and desthiobiotin is controlled by the biotin concentration in the medium. 3. the unknown vitamer becomes labelled when the organism is grown in the presence of radioactive pimelic acid. 4. chromatographic procedures were developed for the purification of the radioactive vitamer. 5. the vitamer is extremely stable in concentrated acid but gives rise to new vitam ... | 1966 | 16742432 |
| biological breakdown of benzylpenicillin by preformed mats of penicillin-producing organisms. | 1. penicillium chrysogenum and aspergillus flavus degraded benzylpenicillin in the same way. 2. degradation of the antibiotic was initiated by the cleavage of phenylacetic acid from 6-aminopenicillanic acid. 3. phenylacetic acid was left unchanged whereas 6-aminopenicillanic acid was degraded into cysteine and valine. this reaction is probably complex. 4. cysteine was not utilized but valine was cleaved into acetone and glycine. catabolism of valine by the preformed mats of the two moulds confir ... | 1966 | 16742463 |
| nonessentiality of boron in fungi and the nature of its toxicity. | an investigation was undertaken to determine whether any of the following fungi had a requirement for boron (b): saccharomyces cerevisiae, aspergillus niger, neurospora crassa, and penicillium chrysogenum. boron was unessential, and hence a study was made of the concentrations of b that reduced the growth of s. cerevisiae and p. chrysogenum and the mode of action of the b toxicity. fifty and 4000 mg b/liter, respectively, significantly (5% level) reduced the growth of the latter 2 species.in bot ... | 1966 | 16656256 |
| differences in diploids synthesized between the same parental strains of penicillium chrysogenum. | 1966 | 5297393 | |
| biosynthesis of benzylpenicillin. ii. effect of precursor amino acids on the biosynthesis of benzylpenicillin by the washed, resting cells of penicillium chrysogenum. | 1966 | 5942689 | |
| negapillin, a new antibiotic isolated from metabolites of penicillium chrysogenum. | 1966 | 5952016 | |
| the inorganic sulfate transport system of penicillium chrysogenum. | 1966 | 5957709 | |
| an unusual amino sugar derivative from the cell wall of penicillium notatum. | 1966 | 5970173 | |
| [isolation of alpha-amylase from the mycelium penicillium chrysogenum strain 194]. | 1966 | 5986874 | |
| incorporation of amino acids into protein by cell-free extracts of penicillium chrysogenum. | 1966 | 5988123 | |
| [organic phosphorus compounds of penicillium chrysogenum containing phosphorus determined as orthophosphate]. | 1966 | 5994934 | |
| nonenzymatic and enzymatic hydroxylation of phenylacetic acid in penicillium chrysogenum cultures. | 1966 | 5998188 | |
| studies on nitrogen metabolism of penicillium chrysogenum thom. i. effects of lactose and sucrose additions on nitrogen metabolism. | 1965 | 5824967 | |
| studies on nitrogen metabolism of penicillium chrysogenum thom. ii. amino acid metabolism and its relation to the biosynthesis of penicillin. | 1965 | 5824968 | |
| penicillin acylase activity of penicillium chrysogenum. | the penicillin acylase activity of penicillium chrysogenum was studied. washed mycelial suspensions of a high penicillin-producing and a nonproducing strain were found to be similar in respect to relative acylase activity on benzylpenicillin, 2-pentenylpenicillin, heptylpenicillin, and phenoxymethylpenicillin. the relative rates for both strains, as determined by 6-aminopenicillanic acid formation, were approximately 1.0, 2.5, 3.5, and 6.0 on the penicillins in the order given. the high producin ... | 1965 | 5867654 |
| invertase production by penicillium chrysogenum and other fungi in submerged fermentation. | a study was made of penicillium chrysogenum and some other fungi to determine the relative distribution of intra- and extracellular invertase produced by them in submerged fermentation. the proportion of each type of enzyme varied with the organism and the period of fermentation. more of the enzyme initially bound to the mycelium was released into the medium with the progress of fermentation. differences were observed in the effects of cultural conditions on enzyme production in p. chrysogenum a ... | 1965 | 5867655 |
| [the influence of lactose concentrate on the activity of penicillin formation from penicillium chrysogenum]. | 1965 | 5868968 | |
| [isolation and purification of ribonuclease from the mycelium of penicillium chrysogenum stain 194]. | 1965 | 5869036 | |
| [general characteristics of some new nucleotide-containing acid soluble compounds isolated from mycelia of penicillium chrysogenum thom]. | 1965 | 5871318 | |
| [investigation of ribonuclease and desoxyribonuclease activity of the mycelium of penicillium chrysogenum, strain 194]. | 1965 | 5871935 | |
| heterozygous diploids of penicillium chrysogenum and their segregation patterns. | 1965 | 5881991 | |
| production of calcium gluconate by penicillium chrysogenum in submerged culture. | the waste mycelium of penicillium chrysogenum ha-10 (obtained at the end of penicillin fermentation), or a 24-hr-old freshly grown vegetative inoculum of this organism, was found to utilize glucose for the production of calcium gluconate by submerged fermentation in shake flasks. after 72 to 96 hr of fermentation at 24 c, 90 to 95% of the reducing sugar from the 15% glucose medium was converted to calcium gluconate. reuse of the mycelium for successive experiments reduced the fermentation period ... | 1965 | 5325935 |
| exocellular deoxyribonuclease i of penicillium chrysogenum: i--partial purification & properties of the enzyme. | 1965 | 4222386 | |
| studies in valine biosynthesis. vii. an enzymatic clue in penicillium chrysogenum and other organisms. | 1965 | 14277682 | |
| use of penicillium chrysogenium mycelium as animal food. | the mycelial cake of penicillium chrysogenum, when dried and specially processed, has been found to serve as a source of protein in place of soybean meal in the diet of experimental mice. animals were fed a control diet first, and an increase in weight proved the formulation to be satisfactory. the changeover from the control to the experimental diet was sudden, and initially caused a decrease in the weight of the experimental mice. however, at the end of a 29-day period, the experimental mice s ... | 1965 | 14325891 |
| sequential primary and secondary shunt metabolism in penicillium chrysogenum. | penicillium chrysogenum was grown on a rich medium and on a more sparse medium which favored penicillin production. mycelia grown on both media were examined for changes in lipid, mannitol, erythritol, glycerol, pentitol, trehalose, and residual mycelium, and the filtrates were examined for penicillin. penicillin production took place after the bulk of trehalose, polyol, and lipid had accumulated, and hence the sequential pattern of primary and secondary shunt metabolism, as observed in the case ... | 1965 | 14341595 |
| [determination of amylase in mycelia of penicillium chrysogenum, strain 194]. | 1964 | 14347134 | |
| attempted genetic transformation in penicillium chrysogenum. | 1964 | 14085567 | |
| [on orthophosphate absorption by penicillium chrysogenum mycelia]. | 1964 | 14194903 | |
| properties of heterozygous diploids between stains of penicillium chrysogenum selected for high penicillin yield. | 1964 | 14195251 | |
| the isolation of trehalose and polyols from the conidia of penicillium chrysogenum thom. | 1964 | 14224822 | |
| [influence of several polymers in the fermentation of "penicillium chrysogenum"]. | 1964 | 14249968 | |
| [study of the mechanism of orthophosphate absorption by mycelia of penicillium chrysogenum]. | 1964 | 14264925 | |
| on the relationship between the effect of phenol on the oxygen uptake and the viability of penicillium notatum spores. | 1963 | 14101600 | |
| isolation of auxotrophs of penicillium chrysogenum and their penicillin yields. | 1963 | 14114924 | |
| heterokaryon studies and the genetic control of penicillin and chrysogenin production in penicillium chrysogenum. | 1963 | 14114925 | |
| formation and segregation of heterozygous diploids between a wild-type strain and derivatives of high penicillin yield in penicillium chrysogenum. | 1963 | 14114926 | |
| [penicillin biosynthesis by highly productive strains of penicillium chrysogenum on media with different carbohydrates]. | 1963 | 14124720 | |
| sorbic hydroxamic acid, an antifungal agent effective over a wide ph range. | sorbic hydroxamic acid was prepared from sorbic acid by esterification and treatment with hydroxylamine (mp 133 to 135 c, pk(a) 8.8). its ultraviolet spectrum in acid solution had a single absorption maximum at 262 mmu; in alkaline solution the maximal absorption shifted to 255 mmu and significant absorption appeared at 280 to 300 mmu. at concentrations of 0.1% (w/v), sorbic hydroxamic acid prevented the growth of aspergillus niger, penicillium notatum, botrytis cinerea, cladosporium herbarum, a ... | 1963 | 16349636 |
| nitrogenous components of phospholipids extracted from penicillium chrysogenum. | 1963 | 14072044 | |
| intermediates in inorganic sulfate utilization by penicillium chrysogenum. | 1963 | 14084584 | |
| ballistic disruption of penicillium chrysogenum cells. | the use of glass beads in a high-speed mixing device to rupture organisms was applied to molds. the use of a mixer in which the propellor shaft enters from the top into a metal mixing chamber made it possible to immerse the whole device in a salt water and ice mixture so that the temperature of the glass-bead slurry could be kept below 5 c without difficulty. mycelia, glass beads, and buffer in a 1:2:3 (w/w) ratio gave above 95% breakage in 15 min with penicillium chrysogenum cells and in 4 min ... | 1962 | 13952345 |
| an analysis of the cell walls of penicillium chrysogenum. | 1962 | 13952347 | |
| [observations on the proteolytic system of penicillium chrysogenum]. | 1962 | 13988083 | |
| the effect of age on the viability of penicillium notatum spores in water and solutions of phenol. | 1962 | 14020403 | |
| [some data on the nature of the volutin granules in penicillium chrysogenum]. | 1962 | 14028181 | |
| [comparative studies on the process of development of penicillium chrysogenum, strain no. 194, and a new hybrid]. | 1962 | 14028182 | |
| studies on the kinetics of fungicidal action. ii. the effect of temperature on the viability of penicillium notatum spores in water and solutions of phenol. | 1962 | 13878488 | |
| [effect of fats on the synthesis of 6-aminopenicillic acid during deep cultivation of penicillium chrysogenum]. | 1962 | 13900739 | |
| [synthesis of 6-aminopenicillic acid during the fermentation of penicillium chrysogenum on a medium with precursors]. | 1962 | 14464704 | |
| [studies on the respiration of penicillium chrysogenum]. | 1962 | 14464707 | |
| [a method for the isolation of crystalline 6-methylpenicillic acid from liquid culture media obtained during the fermentation of the microganism penicillium chrysogenum without the precursor]. | 1962 | 14497628 | |
| [the genetics of penicillium chrysogenum. v. reversion by manganese chloride of the lethal action and chromosomal damage produced by nitrogen mustard]. | 1961 | 14476208 | |
| comparative study of penicillin production with vegetative and spore inoculum of penicillium chrysogenum. | 1961 | 16349598 | |
| growth inhibition of insects and a fungus by indole-3-acetonitrile. | indole-3-acetonitrile obtained from cabbage has been found to inhibit growth of pyrausta nubilalis (hbn.), galleria mellonella (l.), and penicillium chrysogenum. | 1961 | 17754432 |
| [nucleotides of micro-organisms. iii. the structure of a new pyridine nucleotide isolated from penicillium chrysogenum thom]. | 1961 | 13910835 | |
| [the genetics of penicillium chrysogenum. iv. effect of some mutagenic agents on the somatic segregation of heterozygous diploids]. | 1961 | 13910841 | |
| the parasexual cycle in penicillium chrysogenum and its application to the production of penicillin. | 1961 | 13910843 | |
| hybridisation of highly active strains of penicillium chrysogenum. | 1961 | 13860451 | |
| [the fate of s-35 sulfate and s-35 methionine in a high-yielding penicillin-producing strain of penicillium chrysogenum and in a mutant nonproductive strain grown in a simple substitution medium]. | 1961 | 13864453 | |
| [nucleotides of microorganisms. i. nucleotides of the mycelium of penicillium chrysogenum thom]. | 1961 | 13864454 | |
| [nucleotides of microorganisms. ii. isolation of adenylsuccinic acid and adenosinosuccini acid from the mycelium of penicillium chrysogenum thom]. | 1961 | 13864456 | |
| [observations on the morphology of penicillium chrysogenum thom in submerged culture. v. a) b) c) d). on the mode of formation of conida of penicillium chrysogenum thom in submerged culture]. | 1961 | 13876578 | |
| production of penicillin with waste mycelium penicillium chrysogenum as the sole source of nitrogen. | 1961 | 13704953 | |
| identification of a compound related to 6-aminopenicillanic acid, isolated from culture media of penicillium chrysogenum. | 1961 | 13686415 | |
| action of mycophenolic acid on unstable diploids of penicillium chrysogenum. | 1961 | 13686418 | |
| isolation of a substance affecting somatic segregation in diploid strains of penicillium chrysogenum and its identification with mycophenolic acid. | 1961 | 13686419 | |
| studies on the kinetics of fungicidal action. i. the effect of concentration and time on the viability of penicillium notatum spores in solutions of phenol. | 1961 | 13692661 | |
| l-arabinose metabolism by cell-free extracts of penicillium chrysogenum. | 1961 | 13692999 | |
| [metabolism of organic acids by penicillium chrysogenum q 176 grown on acetate]. | 1961 | 13730895 | |
| [the fate of 2-14c-labelled acetate in penicillium chrysogenum]. | 1961 | 13730896 | |
| accumulation of intracellular inorganic sulfate by penicillium chrysogenum. | 1961 | 13749681 | |
| [studies on acid-soluble phosphorus compounds from penicillium chrysogenum q-176 in various growth conditions]. | 1961 | 13755010 | |
| sulphur-containing amino acids and peptides in the mycelium of penicillium chrysogenum. | 1960 | 13794417 | |
| the structure of a peptide, containing alpha-aminoadipic acid, cystine and valine, present in the mycelium of penicillium chrysogenum. | 1960 | 13794420 | |
| the physicochemical requirements for the action of penicillium notatum phospholipase b on unimolecular films of lecithin. | 1960 | 13796431 | |
| mutarotase from penicillium notatum. i. purification, assay, and general properties of the enzyme. | 1960 | 13799037 | |
| mutarotase from penicillium notatum. ii. the mechanism of the mutarotation reaction. | 1960 | 13799038 | |
| [production of proteolytic enzyme preparations from the mycelium penicillium chrysogenum]. | 1960 | 13800319 | |
| oxidation of glycolic acid by penicillium chrysogenum. | 1960 | 13695635 | |
| [the structure of galactosyl-lactose, a trisaccharide produced from lactose by penicillium chrysogenum thom]. | 1960 | 13686417 | |
| the isolation of d-valine from penicillium chrysogenum. | 1960 | 13710858 | |
| dissimilation of citric acid by extracts of penicillium chrysogenum. | 1960 | 14400461 | |
| production of inductive amylase by penicillium chrysogenum. | 1960 | 14403254 | |
| the metabolism of 6-amino-penicillanic acid and related compounds by penicillium chrysogenum and its possible significance for penicillin biosynthesis. | 1960 | 13845690 | |
| [stimulation of penicillin formation in a strain of penicillium chrysogenum by compounds of bivalent sulfur]. | 1959 | 14409728 | |
| [effect of stirring on the development of penicillium chrysogenum inmi-243 and penicillin synthesis]. | 1959 | 14426551 | |
| continuous-flow culture of the filamentous mould penicillium chrysogenum and the control of its morphology. | 1959 | 14433236 | |
| repetitive mutagenic treatment and mass-culturing of microorganisms--observations on penicillium chrysogenum. | 1959 | 14441887 | |
| inhibitory effect of fungistatic antibiotics on the production of amylase by penicillium chrysogenum. | 1959 | 14403252 | |
| chemically-induced instabilities in a heterozygous diploid of penicillium chrysogenum. | 1959 | 17247807 | |
| action of manganous chloride on induced somatic segregation in penicillium chrysogenum diploids. | 1959 | 17247836 | |
| myo-inositol in the biosynthesis of benzylpenicillin by the mycelial suspensions of penicillium chrysogenum. | 1959 | 13619673 |