Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [hepatitis e as zoonosis]. | the hepatitis e virus (hev) the causative agent of hepatitis e, is a non-enveloped rna virus. hev is transmitted through oral consumption of contaminated food and water according to the currently knowledge now be considered as zoonosis. the main reservoir of hev are pigs, boars and deer. for the first time hev was isolated from animals (pigs) in 1997 in the u.s. genetic analysis of strains isolated from pigs showed high similarity to strains hev isolated from humans. this was the first evidence ... | 2011 | 21735829 |
| High prevalence of hepatitis B virus infection in multiple myeloma. | Abstract Objective: The aim of the current study is to verify the potential association between multiple myeloma (MM) and HBV/HCV infection. Methods: This retrospective case control trial included 299 MM patients and 299 patients with acute leukemia (AL). Age and sex were matched between the two groups. Results: The HBsAg positivity rate was significantly higher in the MM group (19.4% vs. 12.0% in AL patients; p=0.014). The rate of HCV infection did not differ between the two groups. The inciden ... | 2011 | 21823833 |
| Serological diagnostics of hepatitis E virus infection. | Development of accurate diagnostic assays for the detection of serological markers of hepatitis E virus (HEV) infection remains challenging. In the course of nearly 20 years after the discovery of HEV, significant progress has been made in characterizing the antigenic structure of HEV proteins, engineering highly immunoreactive diagnostic antigens, and devising efficient serological assays. However, many outstanding issues related to sensitivity and specificity of these assays in clinical and ep ... | 2011 | 21704091 |
| Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b. | In late 2005, a postweaning, high mortality syndrome spread rapidly through finishing barns in swine dense areas of the United States. Diagnostic investigations consistently detected porcine circovirus type 2 (PCV2) from diseased tissues. Subsequent genetic analysis revealed that the infectious agent was a PCV2 type termed "PCV2b". Prior to late 2004, only the PCV2a type, but not PCV2b, had been reported in North America. In this communication, we produce severe postweaning multisystemic wasting ... | 2011 | 21684696 |
| Pteropid bats are confirmed as the reservoir hosts of henipaviruses: a comprehensive experimental study of virus transmission. | Bats of the genus Pteropus have been identified as the reservoir hosts for the henipaviruses Hendra virus (HeV) and Nipah virus (NiV). The aim of these studies was to assess likely mechanisms for henipaviruses transmission from bats. In a series of experiments, Pteropus bats from Malaysia and Australia were inoculated with NiV and HeV, respectively, by natural routes of infection. Despite an intensive sampling strategy, no NiV was recovered from the Malaysian bats and HeV was reisolated from onl ... | 2011 | 22049055 |
| first case of anti-ganglioside gm1-positive guillain-barré syndrome due to hepatitis e virus infection. | a 51-year-old previously healthy woman presented with guillain-barré syndrome (gbs) and elevated liver enzymes. further diagnostic investigations showed the presence of an acute hepatitis e infection associated with anti-ganglioside gm1 antibodies. after treatment with intravenous immunoglobulins, the patient made a rapid recovery. here, we report the first case of gbs due to acute hepatitis e virus (hev) infection associated with the presence of anti-ganglioside gm1 antibodies. we also review a ... | 2011 | 21877179 |
| seroprevalence evolution of selected pathogens in iberian wild boar. | a total of 1279 eurasian wild boar (sus scrofa) sera were collected from 2000 to 2011 in the iberian peninsula to reveal time changes in serum antibody prevalences against selected infectious agents (porcine circovirus type 2, pcv2; porcine reproductive and respiratory syndrome virus, prrsv; hepatitis e virus, hev; and erysipelothrix rhusiopathiae) and to identify putative individual or population factors driving such changes. overall seroprevalences were 48%, 26%, 2% and 15% for pcv2, hev, prrs ... | 2011 | 22168900 |
| host risk factors and autochthonous hepatitis e infection. | in developed countries autochthonous hepatitis e infection is caused by hepatitis e virus (hev) genotype 3 or 4 and mainly affects middle aged/elderly men. host factors might explain why older men develop clinically overt disease. | 2011 | 21941192 |
| Detection of negative sense RNA in packaged hepatitis E virions using improved strand specific RT-PCR method. | Current hepatitis E virus (HEV) negative sense RNA detection assays have drawback of false positivity. cDNA synthesis using tag-based primer and Superscript RT-III followed by exonuclease I treatment increased the specificity. Assay could detect as low as 10 copies of negative sense RNA and could be used in detecting low levels of HEV replication in cells. Virus particles in stool samples of hepatitis E patients showed encapsidation of negative sense RNA along with HEV genomic RNA. | 2011 | 22205803 |
| rare, unusual, and less common virus infections after organ transplantation. | the present article reviews the epidemiology, clinical presentation, prevention, and management of rare, unusual, and less common viruses that infect transplant recipients. | 2011 | 22001713 |
| Experimental infection of horses with hendra virus/australia/horse/2008/redlands. | Hendra virus (HeV) is a highly pathogenic zoonotic paramyxovirus harbored by Australian flying foxes with sporadic spillovers directly to horses. Although the mode and critical control points of HeV spillover to horses from flying foxes, and the risk for transmission from infected horses to other horses and humans, are poorly understood, we successfully established systemic HeV disease in 3 horses exposed to Hendra virus/Australia/Horse/2008/Redlands by the oronasal route, a plausible route for ... | 2011 | 22172152 |
| Thermal stability of hepatitis E virus assessed by a molecular biological approach. | Hepatitis E virus (HEV) is a pathogen of emerging concern in industrialized countries. The consumption of wild boar meat has been identified as one risk factor for autochthonous HEV infections. Only limited information is available about thermal stability of HEV, mainly due to the lack of rapid and efficient cell culture systems for measurement of HEV infectivity. | 2011 | 22040359 |
| Survival of hepatitis A and E viruses in soil samples. | Survival of hepatitis A virus (HAV) and hepatitis E virus (HEV) in soil samples spiked with respective viruses was analysed using real-time PCR. Virus-spiked soil samples were incubated at environmental temperature (ET) and 37°C and processed weekly. Both HAV and HEV were less stable at fluctuating ET than at 37°C. Of the 403 soil samples collected in the vicinity of Mutha river, India, 19.1% and 4.9% were found to be contaminated with HAV and HEV, respectively. | 2011 | 21939469 |
| [the etiological identification of an aseptic encephalitis outbreak (ten cases) in a hospital of xiamen city, 2011]. | to identify the etiology of an aseptic encephalitis outbreak (ten cases) in a hospital of xiamen city from 11 to 17 may, 2011. | 2011 | 22041567 |
| Survey of enterovirus infections from hand, foot and mouth disease outbreak in china, 2009. | ABSTRACT: | 2011 | 22054534 |
| A neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge. | Hendra virus (HeV) is a recently emerged zoonotic paramyxovirus that can cause a severe and often fatal disease in horses and humans. HeV is categorized as a biosafety level 4 agent, which has made the development of animal models and testing of potential therapeutics and vaccines challenging. Infection of African green monkeys (AGMs) with HeV was recently demonstrated, and disease mirrored fatal HeV infection in humans, manifesting as a multisystemic vasculitis with widespread virus replication ... | 2011 | 22013123 |
| Effector T cells immune reactivity among patients with acute hepatitis E. | Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis in several developing countries. Information on cellular immune responses during acute hepatitis E is limited. We therefore studied peripheral blood mononuclear cells (PBMCs) from patients with acute hepatitis E and healthy adult subjects who lacked anti-HEV antibodies for enumeration of various T-cell subsets using flow cytometry and to assess HEV-specific T effector cell responses using interferon-gamma ELISPOT assays. The pat ... | 2011 | 21914082 |
| hepatitis e virus-related acute liver failure associated with pure red cell aplasia. | 2011 | 21947733 | |
| The global burden of hepatitis E virus. | We estimated the global burden of hepatitis E virus (HEV) genotypes 1 and 2 in 2005. HEV is an emergent waterborne infection that causes source-originated epidemics of acute disease with a case fatality rate thought to vary by age and pregnancy status. To create our estimates, we modeled the annual disease burden of HEV genotypes 1 and 2 for 9 of 21 regions defined for the Global Burden of Diseases, Injuries, and Risk Factors Study (the GBD 2010 Study), which represent 71% of the world's populat ... | 2011 | 22121109 |
| Molecular epidemiology of hepatitis E virus infections in Shanghai, China. | ABSTRACT: BACKGROUND: Hepatitis E virus (HEV) causes acute or fulminant hepatitis in humans and is an important public health concern in many developing countries. China has a high incidence of HEV epidemics, with at least three genotypes (1, 3, and 4) and nine subtypes (1b, 1c, 3b, 4a, 4b, 4d, 4g, 4h and 4iso far identified. Since genotype 3 and the newly identified subtype 4i have been exclusively limited geographically to Shanghai and its neighboring provinces, the epidemiology of HEV infect ... | 2011 | 22168371 |
| Hepatitis E virus infection as a cause of acute hepatitis in Southern Italy. | Hepatitis E virus (HEV) is a major cause of acute hepatitis in developing countries, whereas it is not considered a major health problem in Western World. | 2011 | 21880560 |
| Hepatitis E virus in rabbits, Virginia, USA. | We identified hepatitis E virus (HEV) in rabbits in Virginia, USA. HEV RNA was detected in 14 (16%) of 85 serum samples and 13 (15%) of 85 fecal samples. Antibodies against HEV were detected in 31 (36%) of 85 serum samples. Sequence analyses showed that HEV from rabbits is closely related to genotype 3. | 2011 | 22099094 |
| seroprevalence study in forestry workers from eastern germany using novel genotype 3- and rat hepatitis e virus-specific immunoglobulin g elisas. | hepatitis e virus (hev) is the causative agent of an acute self-limiting hepatitis in humans. in industrialized countries, autochthonous cases are linked to zoonotic transmission from domestic pigs, wild boar and red deer. the main route of human infection presumably is consumption of contaminated meat. farmers, slaughterers and veterinarians are expected to be risk groups as they work close to potentially infected animals. in this study, we tested four escherichia coli-expressed segments of the ... | 2011 | 22179131 |
| [Epidemiology of viral hepatitis in Mexico]. | The main etiology of liver disease in Mexico is alcohol and viral hepatitis. The aim of the present study was to analyze the current epidemiology of viral hepatitis in Mexico. From 2000 to 2007 the Ministry of Health reported 192 588 cases of hepatitis, 79% HAV, 3.3% HBV, 6% HCV, and 12% without a specific etiologic factor. Due to high endemic areas for HBV infection in native Mexican population, limitations in the diagnostic sensitivity and specificity of the serological immunoassays used to da ... | 2011 | 21877071 |
| Hepatitis e virus and renal transplantation. | 2011 | 22140382 | |
| high prevalence of hepatitis e virus in french domestic pigs. | the importance of the domestic pig reservoir for hepatitis e virus (hev) was assessed by estimating the seroprevalence and prevalence of hev contaminated livers in french slaughter-aged pigs. 6565 sera and 3715 livers were randomly sampled from 186 pig farms throughout the country. taking the sampling design into account, the farm-level seroprevalence was 65% (95% ci 57-74) and 31% (95% ci 24-38) of the slaughter-aged pigs had antibodies against hev. the individual prevalence of hev rna positive ... | 2011 | 21872929 |
| antibodies to henipavirus or henipa-like viruses in domestic pigs in ghana, west africa. | henipaviruses, hendra virus (hev) and nipah virus (niv), have pteropid bats as their known natural reservoirs. antibodies against henipaviruses have been found in eidolon helvum, an old world fruit bat species, and henipavirus-like nucleic acid has been detected in faecal samples from e. helvum in ghana. the initial outbreak of niv in malaysia led to over 265 human encephalitis cases, including 105 deaths, with infected pigs acting as amplifier hosts for niv during the outbreak. we detected non- ... | 2011 | 21966471 |
| The open reading frame 2 initiation site of genotype 4 hepatitis E virus (HEV). | 2011 | 22019389 | |
| hepatitis e. | hepatitis e refers to liver disease caused by the hepatitis e virus (hev), a small, nonenveloped virus with a single-stranded rna genome. the virus has four genotypes, but only one serotype. genotypes 1 and 2 exclusively infect humans, whereas genotypes 3 and 4 also infect pigs and several other mammalian species. though hev does not grow well in cell culture, several aspects of its biology and pathogenesis have been worked out using animal models and cell transfection studies, and by analogy wi ... | 2011 | 21932388 |
| Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus. | Hendra virus (HeV) continues to cause morbidity and mortality in both humans and horses with a number of sporadic outbreaks. HeV has two structural membrane glycoproteins that mediate infection of host cells: the attachment (G) and the fusion (F) glycoproteins that are essential for receptor binding and virion-host cell membrane fusion, respectively. N-linked glycosylation of viral envelope proteins are critical post-translation modifications that have been implicated in roles of structural inte ... | 2011 | 22171062 |
| HEV-specific T-cell responses are associated with control of HEV infection. | Hepatitis E virus (HEV) infection is usually self-limited limited but may lead to acute hepatitis and rarely to fulminant hepatic failure. Persistent HEV infections have recently been described in organ transplant recipients receiving immunosuppressive medications suggesting that HEV is controlled by adaptive immune responses. However, only few studies did investigate HEV-specific T-cell responses and immune correlates for the failure to clear HEV infection have not been established so far. We i ... | 2011 | 22006345 |
| virus hazards from food, water and other contaminated environments. | numerous viruses of human or animal origin can spread in the environment and infect people via water and food, mostly through ingestion and occasionally through skin contact. these viruses are released into the environment by various routes including water run-offs and aerosols. furthermore, zoonotic viruses may infect humans exposed to contaminated surface waters. foodstuffs of animal origin can be contaminated, and their consumption may cause human infection if the viruses are not inactivated ... | 2011 | 22091646 |
| prevalence of hepatitis e virus and porcine caliciviruses in pig farms of guizhou province, china. | backgroud: hepatitis e virus (hev) and caliciviruses are enteric pathogens of humans and animals, and pigs have been considered an important reservoir of these viruses. | 2011 | 22087178 |
| Hepatitis E virus genotype 3f in pigs in New Caledonia. | Hepatitis E virus (HEV) is highly prevalent in farm pigs worldwide and an increasing body of data from industrialised countries suggests that it is an agent of a porcine zoonosis. | 2011 | 22103949 |
| Bacteriological quality of water and water borne diseases in Bangalore: a longitudinal study. | In developing countries diarrhea diseases take a big toll which can be prevented by adequate supply of safe drinking water. Thus a longitudinal study was taken up to determine the morbidity due to water borne diseases and bacteriological quality of water. 150 houses in two different areas, one supplied by bore well and other by tap water was selected by modified cluster sampling. Weekly morbidity details collected. Monthly water samples were assessed for bacteriological quality from main supply, ... | 2011 | 22066282 |
| novel hepatitis e virus genotype in norway rats, germany. | 2011 | 22000397 | |
| integrating overlapping structures and background information of words significantly improves biological sequence comparison. | word-based models have achieved promising results in sequence comparison. however, as the important statistical properties of words in biological sequence, how to use the overlapping structures and background information of the words to improve sequence comparison is still a problem. this paper proposed a new statistical method that integrates the overlapping structures and the background information of the words in biological sequences. to assess the effectiveness of this integration for sequen ... | 2011 | 22102867 |
| New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution. | BACKGROUND: Since previous studies have investigated the population dynamics of Japan-indigenous genotype 3 hepatitis E virus (HEV) using virus sequences, more nucleotide sequences have been determined, and new techniques have been developed for such analysis. AIMS: To prevent future hepatitis E epidemic in Japan, this study aimed to elucidate the cause of past HEV expansion. METHODS: The epidemic history of Japan-indigenous genotype 3 HEV was determined using the coalescent analysis framework. ... | 2011 | 22181032 |
| tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis e virions. | we have previously demonstrated that an intact psap motif in the orf3 protein is required for the formation and release of membrane-associated hepatitis e virus (hev) particles with orf3 proteins on their surface. in this study, we investigated the direct interaction between the orf3 protein and tumour susceptibility gene 101 (tsg101), a cellular factor involved in the budding of viruses containing the p(t/s)ap late-domain, in plc/prf/5 cells expressing the wild-type or psap-mutated orf3 protein ... | 2011 | 21880841 |
| acute hepatitis associated with autochthonous hepatitis e virus infection--san antonio, texas, 2009. | locally acquired hepatitis e infection is increasingly being observed in industrialized countries. we report 2 cases of autochthonous acute hepatitis e in the united states. hepatitis e virus genotype 3a related to us-2 and swine hepatitis e virus strains was isolated from one of the patients, indicating potential food-borne or zoonotic transmission. | 2011 | 21896699 |
| phylogenetic analysis of the full genome of rabbit hepatitis e virus (rbhev) and molecular biologic study on the possibility of cross species transmission of rbhev. | rabbit hev strains were isolated in china from farmed rabbits, which may be a reservoir of a novel genotype of hev. however, there is little information regarding host range and zoonotic potential of rabbit hev. a previous study from this group identified 25 specific nucleotide positions as possibly being involved in specifying the host range of hev and/or in determining the severity of hepatitis e disease, whereas this previous analysis did not extend to the new rabbit hevs. consequently the co ... | 2011 | 21945590 |
| coexistence of igm antihepatitis a virus and igm antihepatitis e virus in acute viral hepatitis: a prospective, multicentre study in korea. | this study investigated the clinical, serological and molecular characteristics of coexistence of both immunoglobulin m (igm) antihepatitis a virus (hav) and igm antihepatitis e virus (hev) in acute viral hepatitis using a prospective, multicentre design. among a total of 771 symptomatic cases with acute viral hepatitis enrolled in a korean city from september 2006 to august 2008, coexistence of igm anti-hav and igm anti-hev was found in 43 patients (a+e group; 6%), while the existence of igm an ... | 2011 | 21914057 |
| potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis e virus in human and various animals in beijing, china. | the aim of this study was to further investigate the prevalence of infection and genotype of hepatitis e virus (hev) among different species of animals, people whose works are related to pigs and the general population in the suburb of beijing, china. serum and faecal samples were collected from 10 animal species and humans. anti-hev was detected by enzyme immunoassays (eia); hev rna was amplified by reverse transcription-nested polymerase chain reaction (rt-npcr) method. pcr products were clone ... | 2011 | 21914080 |
| occurrence of water-borne enteric viruses in two settlements based in eastern chad: analysis of hepatitis e virus, hepatitis a virus and human adenovirus in water sources. | hepatitis e virus (hev) is a common cause of water-borne acute hepatitis in areas with poor sanitation. in 2004 an outbreak of hev infection affected around 2,000 people in eastern chad (dar sila). this paper describes the decrease in the incidence of acute jaundice syndrome (ajs) from 2004 until 2009 when a mean incidence of 0.48 cases/1,000 people/year was recorded in the region. outbreaks of ajs were identified in some of the camps in 2007 and 2008. moreover, water samples from drinking water ... | 2011 | 21976198 |
| surveillance of hepatitis a and e viruses contamination in shellfish in thailand. | to survey for hepatitis a virus (hav) and hepatitis e virus (hev) contamination in edible bivalve shellfish. | 2011 | 21929540 |
| the epidemiology of hepatitis e virus infections in developed countries and among immunocompromised patients. | hepatitis e virus (hev) is an important cause of acute hepatitis in humans worldwide, both as epidemic and sporadic disease. since the virus was identified in 1983, epidemics have occurred regularly in many countries across south and southeast asia when seasonal floods have contaminated drinking water supplies and in africa during humanitarian crises among refugee populations without access to clean water. in addition, sporadic cases and small clusters of hev infections have been recognized thro ... | 2011 | 22114964 |
| hepatitis e virus antibodies in blood donors, france. | using a validated sensitive assay, we found hepatitis e virus (hev) igg in 52.5% of voluntary blood donors in southwestern france. this finding suggests hev is highly endemic to this region. the high hev prevalence may reflect local dietary practices, such as eating uncooked pork and game products. | 2011 | 22172156 |
| widespread distribution of hepatitis e virus in spanish pig herds. | abstract: | 2011 | 21999141 |
| detection of hepatitis e virus rna in plasma mini-pools from blood donors in england. | 2011 | 21957873 | |
| seroprevalence and molecular detection of hepatitis e virus in yunnan province, china. | in this study, the prevalence and characteristics of hepatitis e virus (hev) in pigs and the general population in the yunnan province, china, were evaluated. nine hundred sixty sera, 95 liver and 60 feces samples were randomly collected from pig farms and abattoirs, in addition 173 human sera were sampled in the provincial capital city for a serological survey and an rt-npcr assay. the screening results showed that among 621 samples collected from five pig farms, the hev-specific igg positive r ... | 2011 | 21874521 |
| current status of hepatitis e virus infection in korea. | hepatitis e virus (hev) is an emerging pathogen associated with acute viral hepatitis, and hev is becoming increasingly recognized. approximately 2% of acute viral hepatitis is caused by hev, and 18 cases of hepatitis e have been reported in korea. of these cases, only two have involved a history of travel from india, which suggests that they were imported cases. the remaining reported cases include a sporadic case of acute hepatitis e with genotype 4 hev isolates and identification of the full ... | 2011 | 22195239 |
| a549 and plc/prf/5 cells can support the efficient propagation of swine and wild boar hepatitis e virus (hev) strains: demonstration of hev infectivity of porcine liver sold as food. | recent evidence has indicated the cross-species transmission of hepatitis e virus (hev) from pigs and wild boars to humans, causing zoonosis, mostly via consumption of uncooked or undercooked animal meat/viscera. however, no efficient cell culture system for swine and boar hev strains has been established. we inoculated a549 cells with 12 swine and boar hev strains of liver, feces, or serum origin at an hev load of ≥2.0 × 10(4) copies per well and found that the hev progeny replicated as efficie ... | 2011 | 22048607 |
| mri findings in acute hendra virus meningoencephalitis. | aim: to describe serial changes in brain magnetic resonance imaging (mri) in acute human infection from two outbreaks of hendra virus (hev), relate these changes to disease prognosis, and compare hev encephalitis to reported cases of nipah virus encephalitis. materials and methods: the mri images of three human cases (two of which were fatal) of acute hev meningoencephalitis were reviewed. results: cortical selectivity early in the disease is evident in all three patients, while deep white matte ... | 2011 | 22133593 |
| [experience in the diagnosis of hepatitis e in a tropical infectious diseases unit.] | the hepatitis e virus (hev) is endemic in some developing countries. it produces acute hepatitis in sporadic cases or epidemics. the main transmission route is faecal-oral by contaminated waters. in developed countries the cases described are more and more frequent, mainly due to population movement (travellers, immigrants, international adoptions), although there have also been increases in the local population. we currently have serological and molecular techniques for the diagnosis of this in ... | 2011 | 22100778 |
| atypical presentation of cytomegalovirus infection in a liver transplant patient. | cytomegalovirus (cmv) is the most common viral infection in solid organ transplant recipients. symptomatic infection usually presents with fever, pneumonia, colitis, or cytopenia. we describe a case of symptomatic cmv infection in a liver transplant recipient presenting with atypical symptoms of only persistent nausea and vomiting, in the absence of classical symptoms and signs; thus, highlighting the importance of high index of suspicion of cmv in immunocompromised patients, keeping in mind the ... | 2011 | 25755388 |
| acute and chronic hepatitis e in patients infected with human immunodeficiency virus. | 2011 | 20384963 | |
| molecular epidemiology of hepatitis e virus in humans, pigs and wild boars in sweden. | hepatitis e infections in humans are usually acquired in endemic countries in asia or africa. in sweden 17 cases infected in europe, between 1993 and 2009, were identified. all had clinical hepatitis e with unknown source of infection. hepatitis e virus (hev) was identified in faecal samples from 63 piglets in 12 pig farms in sweden. hev was also identified in blood from 13 out of 159 investigated swedish wild boars from nine counties. partial hev genomes from humans, pigs and wild boars were se ... | 2011 | 20546635 |
| homology model and potential virus-capsid binding site of a putative hev receptor grp78. | p239, a truncated construct of the hepatitis e virus (hev) orf2 protein, has been proven able to bind with a chaperone, grp78, in both an in vitro co-immune precipitation test and an in vivo cell model. we previously solved the crystal structure of e2s-the c-terminal domain of p239 involved in host interactions. in the present study, we built a 3d structure of grp78 using homology modeling methods, and docked this molecule with e2s using the zdockpro module of the insightii software package. the ... | 2011 | 20628775 |
| infrequent detection of hepatitis e virus rna in pregnant women with hepatitis e virus antibodies in spain. | 2010 | 20629948 | |
| hepatitis e virus and person-to-person transmission. | 2010 | 20635871 | |
| introduction to supplement issue pathogencombat: reducing food borne disease in europe--control and prevention of emerging pathogens at cellular and molecular level throughout the food chain. | 2010 | 20638144 | |
| viral rna but no evidence of replication can be detected in the peripheral blood mononuclear cells of hepatitis e virus-infected patients. | summary. hepatitis e virus (hev) infection is an important cause of acute viral hepatitis in several developing countries but has recently been shown to cause chronic hepatitis in immunosuppressed persons. other hepatotropic viruses that cause chronic infection have been shown to infect peripheral blood mononuclear cells (pbmcs) and to persist in those cells. we therefore decided to look for evidence of replication of hev in pbmcs obtained from patients with acute hepatitis e, using strand-speci ... | 2010 | 20659304 |
| a novel model of lethal hendra virus infection in african green monkeys and the effectiveness of ribavirin treatment. | the henipaviruses, hendra virus (hev) and nipah virus (niv), are emerging zoonotic paramyxoviruses that can cause severe and often lethal neurologic and/or respiratory disease in a wide variety of mammalian hosts, including humans. there are presently no licensed vaccines or treatment options approved for human or veterinarian use. guinea pigs, hamsters, cats, and ferrets, have been evaluated as animal models of human hev infection, but studies in nonhuman primates (nhp) have not been reported, ... | 2010 | 20660198 |
| a simple feature representation vector for phylogenetic analysis of dna sequences. | in this study, a simple 4k-dimension feature representation vector is proposed to reconstruct phylogenetic trees, where k is the length of a word. the vector is composed of elements which characterize the relative difference of biological sequence from sequence generated by an independent random process. in addition, the variance of a vector which is obtained by averaging every column of feature representation matrix is employed to determine appropriate word length. in our experiments, reliable ... | 2010 | 20665972 |
| detection rates of the swine torque teno viruses (ttvs), porcine circovirus type 2 (pcv2) and hepatitis e virus (hev) in the livers of pigs with hepatitis. | porcine circovirus type 2 (pcv2) and hepatitis e virus (hev) are the most recently recognized causes of infectious hepatitis of pigs and may or may not act independently in the development of the disease. recently it has been suggested that swine torque teno viruses (ttvs), in co-infections with some swine viral pathogens, may potentiate the severity of disease. in order to search for virological cofactors associated with infectious hepatitis in pigs, we investigated the liver tissues, to determ ... | 2010 | 20676762 |
| hepatitis e virus excretion can be prolonged in patients with hematological malignancies. | hepatitis e virus (hev) is transmitted via the fecal-oral route and locally acquired sporadic hepatitis e can occur in western countries. chronic hepatitis e virus infections have been recently described in solid organ transplant recipients. there is little data on the evolution of hepatitis e in patients immunocompromised for other reasons. | 2010 | 20678959 |
| virus infections and type 1 diabetes risk. | common intestinal infections caused by human enteroviruses (hevs) are considered major environmental factors predisposing to type 1 diabetes (t1d). in spite of the active research of the field, the hev-induced pathogenetic processes are poorly understood. recently, after the first documented report on hev infections in the pancreatic islets of deceased t1d patients, several groups became interested in the issue and studied valuable human material, the autopsy pancreases of diabetic and/or autoan ... | 2010 | 20680525 |
| henipavirus: a review of laboratory animal pathology. | the genus henipavirus contains two members-hendra virus (hev) and nipah virus (niv)-and each can cause fatal disease in humans and animals. hev and niv are currently classified as biosafety level 4, and niv is classified as a category c priority pathogen. the aim of this article is to discuss the pathology of laboratory animal models of henipavirus infection and to assess their suitability as animal models for the development and testing of human therapeutics and vaccines. there has been conside ... | 2010 | 20682803 |
| hidden danger: the raw facts about hepatitis e virus. | 2010 | 20695795 | |
| pig liver sausage as a source of hepatitis e virus transmission to humans. | the source and route of autochthonous hepatitis e virus (hev) infections are not clearly established in industrialized countries despite evidence that it is a zoonosis in pigs. we investigated the role of figatellu, a traditional pig liver sausage widely eaten in france and commonly consumed raw, as a source of hev infection. | 2010 | 20695796 |
| characteristics of autochthonous hepatitis e virus infection in solid-organ transplant recipients in france. | hepatitis e virus (hev) infections can lead to chronic hepatitis in immunocompromised patients. we have investigated the risk factors for hev infection among solid-organ transplant recipients and the characteristics of these infections. | 2010 | 20695798 |
| ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection. | hepatitis e virus (hev) infection can evolve to chronic hepatitis in immunocompromised patients. pegylated α-interferon can effectively treat chronic hev infection after liver transplantation but is contraindicated for kidney transplantation. we assessed the antiviral effect of ribavirin monotherapy in patients with chronic hev infection following kidney transplantation. | 2010 | 20708006 |
| a nationwide survey for prevalence of hepatitis e virus antibody in qualified blood donors in japan. | in previous studies, we reported the transmission of hepatitis e virus (hev) by transfusion, and the frequent detection of hev markers in japanese blood donors with elevated alt levels. for the current study, we carried out a nationwide survey of the prevalence of igg anti-hev in qualified blood donors throughout japan. | 2010 | 20576022 |
| serologic assays specific to immunoglobulin m antibodies against hepatitis e virus: pangenotypic evaluation of performances. | six immunoassays for detecting immunoglobulin m antibodies to hepatitis e virus were evaluated. serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis e virus infection constituted the test panels. diagnostic sensitivities and specificities as well as interassay agreement varied widely. analytical sensitivity limits also were determined and were found to be particularly disparate. | 2010 | 20578874 |
| study of cellular immune response against hepatitis e virus (hev). | summary. hepatitis e virus infection (hev) is a major cause of acute viral hepatitis in the developing world. the immunopathology of hev infections has not yet been elucidated. the virus is noncytopathic, and therefore, liver injury may be attributed to immune-mediated damage by cytotoxic t cells and natural killer cells. therefore, we studied the nature of immune cells involved in hev-induced liver damage using immunohistochemistry in liver biopsies taken from patients with hev-induced acute li ... | 2010 | 20579277 |
| rna 5'-triphosphatase activity of the hepatitis e virus helicase domain. | hepatitis e virus (hev) has a positive-sense rna genome with a 5'-m7g cap. hev open reading frame 1 (orf1) encodes a polyprotein with multiple enzyme domains required for replication. hev helicase is a nucleoside triphosphatase (ntpase) with the ability to unwind rna duplexes in the 5'-to-3' direction. when incubated with 5'-[gamma-(32)p]rna and 5'-[alpha-(32)p]rna, hev helicase released (32)p only from 5'-[gamma-(32)p]rna, showing specificity for the gamma-beta-triphosphate bond. removal of gam ... | 2010 | 20592074 |
| molecular detection of hepatitis e virus in sewage samples. | human hepatitis e virus (hev) is considered an emerging pathogen in industrialized countries. in italy, the true burden of hev infection is unknown. molecular hev screening of raw sewage samples from 11 wastewater treatment plants yielded 19 positives (16%; 18 genotype i, 1 genotype iii) evenly distributed throughout italy. evidence that hev could be establishing itself in our region is accumulating and may justify more active surveillance to monitor its spread. | 2010 | 20601505 |
| study on prevalence and genotype of hepatitis e virus isolated from rex rabbits in beijing, china. | summary. a novel genotype of hepatitis e virus (hev) isolated from rabbits is reported. the aim of this study was to confirm and further investigate the prevalence of the novel hev genotype in rabbits in china. sera and faecal samples were collected from farmed rex rabbits in beijing, china. all serum samples were tested for anti-hev antibody by eia. both the serum and the faecal samples were evaluated for detection of hev rna using a nested rt-pcr assay. the nucleotide sequences of rabbit hev w ... | 2010 | 20609076 |
| [development of a multiplex technique for detecting simultaneously hav rna and hev rna.] | the hepatitis e virus (hev) is more and more frequently incriminated in hepatitis episodes. in non-endemic regions, it is clear now that this infection is autochthonous, and certainly a zoonosis and thus, that this virus must not only be assessed in hepatitis cases among travellers in endemic regions. in parallel, in endemic region, where hev, like hav, is mainly water-transmitted, important outbreaks still occur. this article describes the development and validation of a new molecular technique ... | 2010 | 20609530 |
| release of genotype 1 hepatitis e virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact pxxp motif. | hepatitis e virus genotype 1 strain sar55 replicated in subcloned caco-2 intestinal cells and huh7 hepatoma cells that had been transfected with in vitro transcribed viral genomes, and hepatitis e virions were released into the culture medium of both cell lines. virus egress from cells depended on open reading frame 3 (orf3) protein, and a proline-rich sequence in orf3 was important for egress from cultured cells and for infection of macaques. both intracellular orf3 protein accumulation and vir ... | 2010 | 20610720 |
| [liver cirrhosis due to hepatitis e in a kidney transplant patient]. | until recently, hepatitis e was considered to be an infectious disease that resolved without any long-term complications. we describe a 47-year-old woman who presented with a decompensated liver cirrhosis with ascites and peripheral oedema, 14 years after successful kidney transplantation. a previous extensive analysis of persistent liver enzyme disorders had not yielded a diagnosis, whereas now laboratory tests showed slightly abnormal liver results. the ct scan revealed ascites with signs of a ... | 2010 | 20619048 |
| swine as the possible source of hepatitis e virus transmission to humans in thailand. | this report describes a study that provides evidence of hev transmission from pigs to humans in thailand by applying molecular genetics analysis. it was found that viruses recovered from thai patients are closely related to genotype 3 and swine hepatitis e virus in thailand. based on analysis of a 302-base-pair orf2 fragment, the strains investigated belong to subgroup 3e and are closely related to european strains. based on the results obtained, swine are suspected to be a source of hev transmi ... | 2010 | 20628771 |
| chronic hepatitis e virus infection: successful virologic response to pegylated interferon-alpha therapy. | 2010 | 20547885 | |
| brief communication: case reports of ribavirin treatment for chronic hepatitis e. | there is currently no accepted treatment of chronic hepatitis e virus (hev) infection. | 2010 | 20547886 |
| hepatitis e virus is highly prevalent in the danish pig population. | the objective of this study was to examine the prevalence of hepatitis e virus (hev) in the danish pig population. faecal samples from 97 pigs, 1-5 months of age were analysed for hev rna by a new priproet real time rt-pcr assay. in addition, serum samples from 71 sow herds were screened for the presence of anti-hev igg antibodies by elisa. the genotype of the detected hev positive samples was estimated based on the melting temperature obtained by the priproet real time rt-pcr assay. the hev pre ... | 2010 | 20554125 |
| phylogenetic analysis and subtyping of acute and fulminant strains of hepatitis e virus isolates of north india with reference to disease severity. | hepatitis e is endemic to the indian subcontinent, with a seroprevalence of 4-20%, and more than 25% of acute viral hepatitis is due to hev. the northern parts of india have been experiencing outbreaks and sporadic cases of hev since 1955. in a total of sixteen hev sequences, ten acute viral hepatitis and 6 fulminant hepatic failure cases were analysed. subtypes 1a and 1c of hev are prevalent in north india, with the subtype-1c showing a trend towards fulminancy. | 2010 | 20559669 |
| [prevalence of hepatitis e virus (hev) and risk factors in pig workers and blood donors]. | hepatitis e virus (hev) is the main causative agent of enterically transmitted non-a non-b hepatitis with a self-limiting clinical presentation in humans. the increasing number of non-immigrant cases of hepatitis e and the high prevalence detected in pigs suggested that this species is a reservoir. several studies have been published describing differences in the prevalence of anti-hev antibodies between people exposed and not exposed to pigs, but the risk factors for the acquisition of the viru ... | 2010 | 20570018 |
| [seroepidemiological survey of sheep hepatitis e virus infection in aksu region of xinjiang autonomous]. | four hundreds and ninety sheep sera from seven breeds raised at eight counties and one city of aksu region in xinjiang were tested by elisa for the presence of antibodies against hepatitis e virus (hev), and the positive rate differences were compared based on administrative areas, breeds and age by chi-square test. the result showed that the general positive rate was 28.98% (142/490), the positive rate were 35.44% (28/79), 29.67% (27/91), 20% (4/20), 40% (12/30), 32.5% (26/80), 38% (19/50), 22. ... | 2010 | 20572346 |
| the two faces of hepatitis e virus. | hepatitis e virus (hev) has at least 2 distinct epidemiological profiles: (1) large outbreaks and epidemics in developing countries, usually caused by hev genotype 1, resulting in high morbidity and mortality among pregnant women and young children, and (2) very few symptomatic cases of hev genotype 3, most cases without symptoms or clear source(s) of infection, but frequent seroreactivity in 5%-21% of asymptomatic persons in developed countries. we urge more epidemiological studies and public h ... | 2010 | 20572761 |
| the complete genome sequence and molecular analysis of human hepatitis e virus genotype iv identified from a korean patient. | hepatitis e virus (hev) was originally identified as the etiological agent of non-hav enterically transmitted hepatitis. one hev strain (fj763142) was identified from an acute viral hepatitis e patient with igm anti-hev in korea. the complete genome sequence consisted of 7,238 nucleotides (nt) plus a 22-nt poly(a) tail. the strain belongs to genotype iv, with 91% homology compared with ab197674, which was found in a japanese patient who had traveled to china. this finding suggests that hev genot ... | 2010 | 20390311 |
| a fatal case of acute hepatitis e among pregnant women, central african republic. | abstract: | 2010 | 20398305 |
| seroprevalence and distribution of hepatitis e virus in various ethnic groups in gansu province, china. | gansu province is located in northwestern china and is home to 45 ethnic groups including han, hui, zang and others. different ethnic groups have varying involvement with livestock and meat consumption, especially pork. to investigate the prevalence of hepatitis e virus (hev) infection and the distribution of hev genotypes among the major ethnic groups in gansu province, 2090 serum samples were collected from individuals from four regions and three ethnic groups, the han, hui and zang. all serum ... | 2010 | 20398803 |
| phylogenetic analysis of avian hepatitis e virus samples from european and australian chicken flocks supports the existence of a different genus within the hepeviridae comprising at least three different genotypes. | using pcrs that amplify regions of helicase and capsid genes, the presence of avian hepatitis e virus (avian hev) was determined in samples from european and australian chicken flocks (collected from 2005 to 2007 and 1986 to 1995, respectively). a total of 27 virus samples from 9 countries were analysed to determine the phylogenetic relationship following pcrs and nucleic acid sequencing of the helicase and capsid regions of 18 avian hev samples. for comparison, helicase and capsid sequences of ... | 2010 | 20399575 |
| [zoonotic potential of the hepatitis e virus]. | the hepatitis e virus (hev), the causative agent of hepatitis e, is a non-enveloped rna virus. the hev genome is formed by a nonsegmented positive-sense rna chain with a 3'-terminal polyadenylated tail and a 5'-terminal cap. according to the currently accepted taxonomy, hev is classified in the genus hepevirus, the sole member of the family hepeviridae. hepatitis e is usually transmitted by the faecal-oral route due to poor sanitation and contamination of drinking water or water for industrial p ... | 2010 | 20401833 |
| should hiv-infected patients with unexplained chronic liver enzyme elevations be tested for hepatitis e virus? | 2010 | 20433358 | |
| [detection and sequences analysis of sheep hepatitis e virus rna in xinjiang autonomous region]. | to understand whether hepatitis e virus (hev) was infectious in sheep in xinjiang. | 2010 | 20815242 |
| dynamics of hev viremia, fecal shedding and its relationship with transaminases and antibody response in patients with sporadic acute hepatitis e. | there is paucity of data regarding duration of fecal excretion and viremia on sequential samples from individual patients and its correlation with serum transaminases and antibody responses in patients with acute hepatitis e. this prospective study was undertaken at a tertiary care center in northern india over 15 months. only those patients of sporadic acute hepatitis e who were in their first week of illness and followed up weekly for liver function tests, igm anti hev antibody and hev rna in ... | 2010 | 20815928 |
| [analysis of the clinical features of and responsive factors on the prognosis in patients with fulminant hepatic failure]. | to judge the prognosis in the patients with fulminant hepatic failure and to provide the evidences of correct therapy. | 2010 | 20825718 |
| seroepidemiology of a second epidemic of hepatitis e in a population that had recorded first epidemic 30 years before and has been under surveillance since then. | large-scale waterborne epidemics of hepatitis e occur in developing countries. it is not known why these epidemics occur repeatedly and selectively in adult population? | 2010 | 20827406 |
| low prevalence of hepatitis e infection among pregnant women in madrid, spain. | hepatitis e virus, a cause of sporadic hepatitis in developed countries is present in spain. the aims of this study were to determine whether the prevalence of igg anti-hepatitis e virus antibodies has increased in recent years in spain and the prevalence in a study population at risk of developing the disease following the infection. serum samples from 1,040 women in the first trimester of pregnancy were studied. the prevalence rate of 3.6% has not increased significantly since 1999 in spite of ... | 2010 | 20827762 |