Publications

chronic effect of left ventricular assist pumping on right ventricular function.	we evaluated right ventricular (rv) function during left ventricular assist device (lvad) pumping during acute and chronic experiments in both normal hearts and hearts with left ventricular failure. an lvad was implanted between the left atrium and the descending aorta of goats. the lvad was pumped in a counterpulsation mode and at maximum bypass flow for 4-6 weeks in chronic experiments. the following results were obtained: 1) lvad pumping itself did not affect rv function, even after 6 weeks o ...	1988	3196588
[3h]imipramine binding in the retinas of chickens and pigs.	high-affinity [3h]imipramine binding sites detected in the brain are associated with the neural uptake mechanism for serotonin. in this study [3h]imipramine binding in the retinal synaptosomal p2-fraction, which contains the serotonin-accumulating nerve terminals, was characterized using two different animal species, chicken and pig, and with a wide range of imipramine concentrations. the specific binding of imipramine was saturable. when homogenates were prepared from fresh retinas, a high-affi ...	1988	3197769
dog owners and their use of veterinary services.		1988	3198454
priming and boosting of the rabbit intestinal immune system with live and killed, smooth and rough vibrio cholerae cells.	cholera disease can be induced in the rabbit by ligation of the cecum (c) followed by duodenal inoculation (di) of virulent vibrio cholerae organisms (dic model). when the cecum is not ligated, di does not induce disease. in contrast, the animals are primed which becomes apparent upon challenge with live v. cholerae in the dic model. such animals are vibriocidally protected. this protection is characterized by absence of disease symptoms, rapid disappearance of v. cholerae from the feces and pre ...	1988	3200161
low incidence of fertilisation in superovulated cows: a physiological explanation.		1988	3201685
autocrine differentiation-inhibiting factor (adif) from chicken erythroleukemia cells acts on human and mouse early bfu-e erythroid progenitors.	tsaev-lscc hd3 chicken erythroid cells transformed by the avian erythroblastosis virus (aev) secrete an autocrine differentiation-inhibiting factor, adif, which blocks differentiation without affecting proliferation of the chicken erythroid cells that synthesize and secrete it into the culture medium. the chicken erythroleukemia cell adif activity is not restricted to avians. it prevents dimethylsulfoxide (dmso) from stimulating murine friend erythroleukemia cells to synthesize hemoglobin. adif ...	1988	3202877
tonic pain and social behavior in male rabbits.	the 4 subjects each of 6 all-male colonies of rabbits studied in a seminatural setting rapidly established a dominance hierarchy. a combination of behavioral parameters obtained in two experimental situations was used to assign each individual a quantitative score of dominance. the situations were: 'intermale' activity between the residents and 'intruder test', i.e. the reactivity to the introduction of a male conspecific. fifteen days later, tonic pain (formalin injection) was inflicted on the ...	1988	3202948
report of the committee on the genetic constitution of chromosome 22.		1988	3203538
[sources of calcium ions participating in the activation of the contraction of smooth muscles of the basilar artery under the action of serotonin].		1988	3203779
the biosynthetic origins of rebeccamycin.	experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of tryptophan. evidence is presented that suggests that the alpha-amino group of neither tryptophan unit provides the nitrogen of the phthalimide system.	1988	3204382
[clinical laboratory approach for estimating effective administrative dose of cefoperazone. evaluation of disc susceptibility test and its interpretation system].	to interpret of the cefoperazone (cpz) disc susceptibility test, a 4 category system is used in japan, but a 3 category system is used in the u.s.a. and europe. in the 4 category interpretation system of showa cpz disc the following classification is used: ( ) mic less than or equal to 3 micrograms/ml, (++) mic greater than 3 approximately 15 micrograms/ml, (+) mic greater than 15 approximately 60 micrograms/ml, (-) mic greater than 60 micrograms/ml. in the 3 category system the classification u ...	1988	3204655
interactions of proteins with ganglioside-enriched microdomains on the membrane: the lateral phase separation of molecular species of gd1a ganglioside, having homogeneous long-chain base composition, is recognized by vibrio cholerae sialidase.	the thermotropic behavior (studied by high-sensitivity differential scanning calorimetry) and susceptibility to vibrio cholerae sialidase hydrolysis of large unilamellar vesicles of dipalmitoyl-phosphatidylcholine, containing native gd1a ganglioside or the molecular species of gd1a containing c18:1 or c20:1 long-chain base (c18:1 gd1a; c20:1 gd1a), were studied. vesicles containing ganglioside (10% in molar terms) showed the presence in the heat capacity function of a second minor peak besides t ...	1988	3207723
the escherichia coli lexa repressor-operator system works in mammalian cells.	we have demonstrated the use of the escherichia coli lexa repressor-operator system to down-regulate gene expression in mouse cells. the lexa gene was placed downstream of the rsvltr promoter with polyadenylation and splice signals from sv40. this expression unit was introduced into mouse ltk- cells by calcium phosphate transfection and stable transfectants selected which express lexa protein. we have used the bacterial chloramphenicol acetyltransferase gene (cat) as our reporter gene. transcrip ...	1988	3208758
quantitative measurement of water consumption patterns in lactating female and neonatal fischer 344 rats employing [14c]methylcellulose.	lactating female and neonatal fischer 344 rats were given water containing [14c]methylcellulose, a nonabsorbed marker, over a 24-hr interval on days 13, 15, 18, 21, 24, and 27 postpartum. the amount of water consumed was calculated based on the 14c activity recovered in the feces and gastrointestinal tract. maternal water consumption during the first 28 days postpartum, when expressed as g/kg/day, averaged 2.5 times the level consumed by nonlactating female rats. maternal water consumption peake ...	1988	3209013
[specificity of first and second generation hiv-1 antibody screening tests].	among 9867 sera tested between january and april 1987 by abbott htlv-iii eia (cell culture-derived antigen) 155 reacted repeatedly positive. 22% of these could not be confirmed, while 77% could be confirmed by other tests. the results of 2 sera remained equivocal. subsequently abbott recombinant htlv-iii eia was used and until august of the same year 184 out of 11508 sera gave reproducible positive results. 12% of these could not be confirmed, while 86% could be confirmed. the results of 3 sera ...	1988	3209234
rapid preparation of samples for compositional sugar analysis of the "degraded polysaccharide" fraction of lipopolysaccharides from vibrio cholerae.	a simple and rapid method was devised for direct isolation and fractionation of the "degraded polysaccharide" (dps) fraction of o-antigenic (or endotoxic) lipopolysaccharides (lps) directly from heat-killed vibrio cholerae (o1 and non-o1) cells without separating the lps. neither phenol-water extraction nor ultracentrifuge is needed in this method. v. cholerae nih 41 was used as standard. the cells (3-5 g wet weight) were heated in 5% acetic acid at 100 c for 1.5 hr. the acetic acid extract obta ...	1988	3210996
glucocorticosteroid treatment of vasogenic oedema.	the components of vasogenic oedema associated with brain tumours were investigated in human biopsy material sampled from tumour and peritumoural tissue intraoperatively. sixty patients with glioblastomas, gliomas, meningiomas and metastases, which had been treated with dexamethasone prior to surgery were employed for tissue measurements of water, electrolyte, haemoglobin, serum protein and dexamethasone concentrations. the quantification of serum proteins was achieved with the method described b ...	1988	3213642
r plasmids in environmental vibrio cholerae non-o1 strains.	the occurrence of drug resistance and its plasmid-mediated transferability was investigated in 140 environmental strains of vibrio cholerae non-o1 and 6 strains of vibrio cholerae, both o1 and non-o1, of clinical origin. of the 146 strains tested, 93% were resistant to at least one drug and 74% were resistant to two or more antibiotics. the o1 strains were susceptible to all antibiotics used. a total of 26 of 28 selected resistant wild strains carried r plasmids that were transferable by intrasp ...	1988	3214157
[toxic properties of lipopolysaccharide and lipid a of aeromonas sobria and non 01 vibrio cholerae].		1988	3216765
[immunogenic and antigenic properties of bacterial cells, lipopolysaccharides and lipids a of aeromonas sobria and non 01 vibrio cholerae].		1988	3216766
the maltose-inducible 43 kda major outer membrane protein in vibrio cholerae is immunogenic and common to different isolates.	we have previously demonstrated the presence of a maltose-inducible major outer membrane protein of 43 kda in an el tor inaba strain of vibrio cholerae. the occurrence of similar proteins was examined in several isolates of v. cholerae 01. the results indicate that the 43 kda protein is common to all of the isolates as evidenced by western blotting analysis with antiserum raised against this protein. the 43 kda protein was maltose-inducible in most isolates although some strains exhibited a cons ...	1988	3216777
production of a heat stable enterotoxin by plesiomonas shigelloides.	eight strains of plesiomonas shigelloides were assayed for enterotoxin production in the rabbit ileal loop assay. seven strains required serial in vivo passage in the rabbit's intestine before enterotoxin activity was detected in the cells' filtrate. enterotoxin production was readily lost with subculture of these toxinogenic cells. heat treatment of the cells' filtrate from three strains that had never been passed in vivo led to detectable enterotoxin activity in three of six separate assays. u ...	1988	3216779
cultured neonatal rat oligodendrocytes are enriched in acid hydrolase activities.	we measured the activity of several acid hydrolases in oligodendrocyte and mixed glial (predominantly astrocytic) cell cultures prepared from neonatal rat cerebra. when compared with the mixed glial cultures, the cultured oligodendrocytes exhibited higher levels for all the hydrolases when activities were normalized to protein content. when enzymic activities were examined as a function of dna content, oligodendrocytic alpha-l-fucosidase, beta-d-glucuronidase, arylsulfatase, and n-acetyl-beta-d- ...	1988	3216950
[an elite for work for ants].		1988	3217688
the current status of cholera vaccine development and experience with cholera vaccine trials in volunteers.	in recent years notable advances have been made in the development of improved vaccines to prevent cholera. these new vaccines are administered orally to maximally stimulate intestinal secretory immunity. killed vibrios, given in conjunction with purified b subunit or administered alone, in three spaced doses, caused no adverse reactions and have conferred significant protection in volunteer challenge studies and in field trials. two attenuated mutants of v. cholerae, prepared by recombinant dna ...	1988	3217822
reactogenicity and immunogenicity of oral cholera vaccine in thai volunteers.		1988	3217824
research needs and advances in inhalation dosimetry identified through the use of mathematical dosimetry models of ozone.	knowledge of the quantitative relationship between exposure concentration and delivered dose (i.e., dosimetry) is a fundamental starting point in the evaluation of the toxicity of chemicals, not only for intra- and interspecies comparisons but also for designing experiments that elucidate mechanisms of action and that identify issues or research areas for further study. to these ends a mathematical, lower respiratory tract dosimetry model for gases has been developed which, when linked to experi ...	1988	3217941
[linear system analysis and physiological model in estimating disposition kinetics of sophocarpine in rats].		1988	3218519
a comparative study of the sugar composition of lipopolysaccharides isolated from vibrio cholerae, 'vibrio albensis' and vibrio metschnikovii.	a comparative study was made of the quantitative sugar composition of lipopolysaccharides (lps) isolated from vibrio cholerae (o1 and non o1 groups), 'v. albensis', 'v. proteus' and v. metschnikovii. the amino sugars 4-amino-4,6-dideoxy-d-mannose (perosamine) and 2-amino-2,6-dideoxy-d-glucose (quinovosamine) were present exclusively in lps isolated from s-form o1 group of v. cholerae regardless of serotype (i.e. ogawa or inaba) and biotype (i.e. classical or eltor). classical o1 group v. cholera ...	1988	3221203
crystallographic characterization of human eosinophil charcot-leyden crystals.		1988	3221396
morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin e2, but not of prostaglandin f2 alpha and inhibits prostaglandin e and f outputs from the uterus of ovariectomized rats.	the effects of morphine on the constancy of spontaneous contractions (isometric developed tension = idt and contractile frequency = cf), in uterine strips isolated from ovariectomized rats and the influence of naloxone, were explored. the inotropic responses to added prostaglandins (pgs) e2 and f2 alpha and the influences of morphine and of morphine in the presence of naloxone on pg actions, were also determined. moreover, the synthesis and outputs of pgs e and f from uteri and the effects of mo ...	1988	3222273
toxin profiles of vibrio cholerae non-o1 from environmental sources in calcutta, india.	a collection of vibrio cholerae non-o1 isolated from the aquatic environs of calcutta, a cholera-hyperendemic area, were examined for the production of cholera toxin (ct), shiga-like toxins (vero toxins), heat-stable enterotoxin, and hemolysins. two (0.5%) v. cholerae non-o1 isolates produced ct. the dna from both these isolates also hybridized with a dna probe containing sequences encoding the a subunit of ct. none of the strains produced shiga-like toxins or heat-stable enterotoxin. hemolytic ...	1988	3223774
degenerative changes in dog articular cartilage induced by a unilateral tibial valgus osteotomy.	we present preliminary details of the changes that occur in a new model for the study of degenerative arthritis which does not involve intraarticular surgery. a unilateral valgus tibial osteotomy was performed in a group of 8 skeletally mature dogs of mixed breed and sex. proximal tibial cartilages, femoral condyles and patellas were examined in operated and unoperated knees of experimental and unoperated dogs. lesions were examined histologically and analyses were made of 35so4 uptake and uroni ...	1988	3224676
genetic distance of two fibrillar collagen loci, col3a1 and col5a2, located on the long arm of human chromosome 2.	two of the human fibrillar collagen genes, proa1(iii) (col3a1) and proa2(v) (col5a2), map to the same region of the long arm of chromosome 2. to establish the genetic distance between the two loci, we analyzed the segregation of col3a1 and col5a2 rflps in five families informative for the two loci specific markers. we found that the maximum lod score was 9.33 at a recombination frequency of theta = 0.00. the data therefore provide strong evidence for tight linkage between two evolutionarily rela ...	1988	3224983
in vitro effect of xipamide on sodium-potassium transport systems in human erythrocytes.	the in vitro effects of xipamide in a concentration range of 10(-8) to 10(-2) m were investigated on various na+ and k+ transport systems in human red blood cells. xipamide inhibited the anion carrier or dids-sensitive lico3- -influx starting from a concentration of 10(-5) m. however, a decrease in the na+, k+-pump and the na+, k+-cotransport activity and a rise in the passive permeability of the cell membrane was only observed starting from a concentration of 10(-4) m xipamide.	1988	3226221
chlamydial pneumonia of infancy in siblings.	we describe two brothers born 16 months apart who were hospitalized with culture-proved chlamydial pneumonia of infancy due to the same immunotype of chlamydia trachomatis. presumably the mother had either been chronically infected or had been reinfected. chlamydial pneumonia of infancy is a preventable disease if genital infection in pregnant women is diagnosed and treated. however, if pregnant women at high risk are not screened for c. trachomatis, multiple offspring may acquire the infection ...	1988	3227475
excision of cutaneous tumors in the horse using histologic guidance.	a highly successful surgical technique for removing cutaneous tumors in humans was used in seven horses with cutaneous squamous cell carcinoma (n = 3) or sarcoid (n = 4). in humans, the complete underside of the tumor is evaluated histologically by processing horizontal sections from the tumor base, and orientation between the wound surface and the undersurface of the excised tumor is maintained by mapping both surfaces. the technique ensures that small foci of residual tumor can be located accu ...	1988	3227634
optokinetic nystagmus thresholds of dark-adapted rcs rats.	the thresholds of dark adapted rcs rats and controls were estimated from optokinetic responses to blue stimuli, and compared to thresholds derived from b-wave stimulus/response functions. the rats were tested at ages 25, 30 and 35 days, a period during which the rcs degeneration is evolving and normal retinal development is proceeding. at all ages the okn thresholds of control rats were lower than those of the rcs rats, but only by age 30 days did b-wave thresholds discriminate rcs from controls ...	1988	3227653
giant cervical polyp due to a foreign body in a 'virgin'.	a 17-year-old virgin who had a giant cervical polyp which had developed through a foreign body and protruded out of the hymen was evaluated; the aetiological significance of the foreign body in the formation of the cervical polyp is discussed.	1988	3228410
nontoxigenic 01 vibrio cholerae in peru: a report of two cases associated with diarrhea.	two 01 vibrio cholerae, e1 tor strains, serogroup ogawa were isolated from diarrheal stool material of two north american males residing or visiting in peru. no other enteric pathogens were found. these strains did not produce cholera toxin as detected by enzyme-linked immunosorbent and y1 adrenal cell assays, nor did they hybridize with an oligonucleotide probe for heat-labile (lt) toxin of escherichia coli. these two cases are the first reports of 01 v. cholerae isolated from clinical specimen ...	1988	3229091
production and purification of cholera toxin.		1988	3231099
fine structural aspects of secretory processes in a pentastomid arthropod parasite in its mouse and rattlesnake hosts.	the histology and development of three extensive glands in the porocephalid pentastomid porocephalus crotali is described by light and electron microscopy, during growth of the parasite to an infective stage in the tissues of mouse; the infective stage in rattlesnake definitive hosts is also included. these glands elaborate excretory/secretory components which are channelled, via chitin-lined efferent ductules, on to the parasite cuticle. hook and frontal glands are relatively compact, and withi ...	1988	3232140
bone marrow fibroblasts-conditioned medium regulates the proliferation of leukemic cells.	the effect of normal human bone marrow fibroblasts-conditioned medium (bmf-cm) was studied on the proliferation of k562 cells, and on leukemic cells from patients with acute myelocytic leukemia at the time of diagnosis and chronic myelogenous leukemia (cml) at chronic phase. bmf-cm was obtained from normal human bone marrow fibroblasts by using long-term liquid cultures. bmf-cm suppressed the proliferation of k562 cells and leukemic cells from patients with undifferentiated type of leukemia (m1 ...	1988	3232161
barium-induced contraction of rat vas deferens in calcium-free solution.	barium-induced contraction of smooth muscle through membrane depolarization is well known. participation of calcium in ba2+-induced contraction of smooth muscle has been emphasized. the source of the activator ca2+ translocated by ba2+ is, however, equivocal. the present study employing whole rat vas deferens, compared the ba2+ response of the tissue bathed in ca2+-deprived salt solution with those in normal salt solution. the results indicate that "phasic" component of ba2+-induced contraction ...	1988	3233055
[kidney morphology in hemolytic-uremic syndrome].	morphology of the kidneys in hemolytic-uremic syndrome is considered basing on autopsy findings obtained for 3 infants with 5-17-day history of acute renal failure. a newborn infant of 17 days developed the disease after feto-fetal hemotransfusion when macerated fetus-donor hemolysis products entered the circulation of the fetus-recipient through monochorionic placenta. the second case in an infant of 6 months was due to adtp vaccine. the last infant aged 16 months manifested the syndrome in the ...	1988	3233069
cholera epidemic in kharabera purohitana, a village of west rajasthan.		1988	3235123
monoclonal antibodies to vibrio cholerae o1 serotype inaba.	eighteen monoclonal antibodies were generated from mice immunized with vibrio cholerae o1 serotype inaba. reactivities of these antibodies were investigated by slide agglutination, microdilution agglutination, and passive hemagglutination tests. although all antibodies reacted to the inaba-type cells, reactivity to ogawa cells showed some variation. these antibodies were roughly subdivided into three groups by slide agglutination tests and microdilution agglutination tests by using type-specific ...	1988	3235665
surface visualisation of tissue interfaces by scanning electron microscopy. methods for exposure of the basal lamina and associated structures in human amnion.	tissue interfaces such as basal lamina have been traditionally investigated in transmission electron microscopy by sections cut vertical to the lamina, presenting information restricted to a single ultrathin plane. in order to overcome this limitation, a methodology for surface visualisation of the underside cell membranes of the amniotic epithelium, the upper and lower basal lamina surfaces, and their relationship to the stromal collagen has been devised. this involves alkaline, detergent or en ...	1988	3238380
neural transplantation in the cerebral ventricular system.		1988	3239189
nicotine analysis of commercial tobacco products.	the use of aoac standard methods for the determination of nicotine in commercial tobacco products is shown to be inappropriate. the methods do not provide for suitable sample preparation of these products for the analysis and, in addition, they yield high results. evidence is presented that the nicotine or total alkaloids measured includes artifact nicotine. the distillation method was developed at a time when the complex alkaloid chemistry of tobacco was unknown, and does not take into consider ...	1988	3240962
electrophysiological connections of neurons in ventral pallidal regions of the olfactory tubercle with the main olfactory bulb and piriform cortex.	field potential and single unit recordings were used to assess the connections of the olfactory tubercle (ot) with the main olfactory bulb (mob) and the piriform cortex (pc) in urethane-anesthetized rats. current generators of depth profiles evoked in ot following mob stimulation were localized 300 microns superficial to those elicited by pc shocks, suggesting that afferents from the mob and pc end in different regions of the ot. following mob and pc stimulation antidromically invaded neurons we ...	1988	3241647
the effect of methylxanthines on morphine analgesia in mice and rats.	the influence of various doses of caffeine and theophylline on analgesic effect of morphine was tested in mice and rats in the hot plate and tail immersion tests. caffeine in rats potentiated the morphine analgesia in both tests in a dose-dependent manner. in mice the caffeine-morphine interaction was biphasic: lower caffeine doses (10 and 25 mg/kg) inhibited, while higher (75 and 100 mg/kg) potentiated the analgesic effects of morphine. theophylline interacted with morphine in a manner similar ...	1988	3241763
system for exposing chicks to experimental intermittent electric shock.	a system for imposing mild electric shock on chicks was developed to study effects on health, behavior, and performance. a floor of parallel steel rods was wired so that the chick's foot or feet completed an electric circuit. droppings spanning the gap between energized rods and ground rods caused short-circuiting occasionally and temporarily, creating a random-interval/random-duration generator. in one 48-h period, on average, the floor remained electrified for 2.7 +/- .19 min (mean +/- sd) the ...	1988	3241786
deprivation in the child's environment: seeking advantage in adversity.	as a plenary address to the international conference on promoting the mental health of children and youth, the author describes the implications and consequences for women and children of economic decline as human deprivation and asks whether supports in a child's environment, which help the child cope with adversity and encourage health, and development can be identified as affordable, reproducable, and in what manner best encouraged. human qualities which promote the best environment i ...	1988	3242785
[total residue analysis of amitraz in the rabbit tissue by gas chromatography].		1988	3243539
developmental changes of tca cycle enzymes in human fetal brain.		1988	3243557
biophysical properties of the lysogenic vibrio phage 'kappa'.		1988	3243565
taxus (yews)--a highly toxic plant.		1988	3245122
taxus (yews)--a highly toxic plant.		1988	3245122
intestinal secretory antibody response induced by an oral cholera vaccine in human volunteers.	the ability is reported of a new oral cholera vaccine composed of vibrio cholerae antigenic fractions to induce a serum and mucosal antibody response after three oral administrations of microgranules to 18 french volunteers according to different protocols of immunization. specific antibodies were detected in the three different fluids studied (saliva, jejunal fluid, serum) in one third of volunteers before vaccination. an increase of specific iga antibody level was observed in jejunal fluids of ...	1988	3245293
cardioselective effects of gallopamil compared with verapamil in the dog heart.	the cardiac and coronary vasodilator effects of gallopamil and verapamil were compared in isolated, blood-perfused papillary muscle, sinoatrial (sa) node and atrioventricular (av) node preparations of the dog. gallopamil and verapamil (0.3-100 micrograms) were injected intra-arterially. in all preparations, gallopamil produced an equipotent but longer-lasting increase in coronary blood flow compared to verapamil. in paced papillary muscle preparations, both drugs reduced the force of contraction ...	1988	3245731
cardioselective effects of gallopamil compared with verapamil in the dog heart.	the cardiac and coronary vasodilator effects of gallopamil and verapamil were compared in isolated, blood-perfused papillary muscle, sinoatrial (sa) node and atrioventricular (av) node preparations of the dog. gallopamil and verapamil (0.3-100 micrograms) were injected intra-arterially. in all preparations, gallopamil produced an equipotent but longer-lasting increase in coronary blood flow compared to verapamil. in paced papillary muscle preparations, both drugs reduced the force of contraction ...	1988	3245731
the buffer capacity of single-site, resting, human dental-plaque fluid.	a carbonate equilibration method was used to measure the buffer capacity of resting plaque fluid collected from single buccal or interproximal sites of upper and lower first molars or anterior teeth. the maximum buffer capacity was 26 m-equiv./l at ph 7.1. the buffer contribution from the measured concentrations of phosphate and carbonate was calculated for each sample. these values were compared with the buffering actually measured and with that expected from organic acids, proteins, and amino ...	1988	3245779
o-antigenic lipopolysaccharides isolated from a marine vibrio, bio-serogroup 1875, possessing an antigenic factor in common with o1 vibrio cholerae.	the chemical and serological characteristics of lipopolysaccharides (lps) isolated from vibrio bio-serogroup 1875 were compared with those of o1 vibrio cholerae lps. vibrio bio-serogroup 1875 lps contained all the component sugars which were found in o1 v. cholerae lps, i.e. glucose, l-glycero-d-manno-heptose, fructose, glucosamine, perosamine and quinovosamine, though the amount of perosamine, a characteristic component of o1 v. cholerae lps, was very low compared with that of o1 v. cholerae lp ...	1988	3246586
[serological cross reactions of lps and lipid a isolated from aeromonas sobria and non 01 vibrio cholerae].		1988	3246916
[characteristics of immunoglobulins specific for lps and lipid a of aeromonas sobria and non 01 vibrio cholerae].		1988	3246917
[the structure of cholera phages 493 and 7227].	electron microscopy and optic diffraction methods were used to determine the main parameters of the morpho-structural organization of cholera phages 493 and 7227. the shape of phage capsids was established, the spiral type of symmetry of phage processes revealed, their adsorption apparatuses described, the number of morphological subunits comprising capsids and process envelopes, and some other parameters determined. it is assumed that the phages under study are new varieties of bacteriophages b ...	1988	3247693
[effect of the growth rate on the activity of nitrogen metabolism enzymes in chemostat cultures of candida diddensii and candida tropicalis].		1988	3247869
[recent progress in diagnosis and treatment of digestive diseases. iii. inflammatory bowel diseases. 6. infectious diarrhea and antibiotics-associated colitis].		1988	3249116
[evaluation of the adhesive properties of non-o1-group vibrio cholerae isolated from people and open reservoirs].		1988	3249577
[effect of the cultivation conditions on the development of adhesive and hemagglutinating properties in the causative agent of cholera].		1988	3249578
[the enzyme activity of the main catabolic metabolism pathways in l-form and typical-form vibrio cholerae cells].		1988	3249579
[transmission and persistence of v. cholerae o:1 infection. facts and hypotheses].		1988	3249899
paracoccidioidomycosis: a sequential histopathologic study of lesions in experimentally-infected rats.		1988	3249901
[evaluation of serum cathepsin b-like activity in liver diseases].		1988	3250921
[evaluation of serum cathepsin b-like activity in liver diseases].		1988	3250921
acute diarrhoeal disease in nigeria: detection of enteropathogens in a rural sub-saharan population.	a retrospective study was carried out to obtain epidemiological data concerning the relative risk of shigella, salmonella, campylobacter jejuni and vibrio cholerae infection in several rural population groups. faecal samples (rectal swab specimens) were cultured from 914 selected children with acute diarrhoeal disease and from a matched control group of 984 non-diarrhoeal children. shigella were more frequently isolated than the other enteropathogens from both the diarrhoeal (12.7%) and control ...	1988	3252601
supplemented schneider's drosophila medium for isolation of leishmania donovani promastigotes.		1988	3252764
effect of heavy metals on the growth of tissue cultures (ii).	the effect of toxic concentrations of three heavy metal compounds on the growth of the secondary callus tissue of nicotiana tabacum l. and ruta graveolens l. was studied. the metal compounds examined were znso4, niso4, cuso4. the metal compounds used were placed in murashige, skoog (1962) and white (1943) culture medium at 10(-6) and 10(-4) m concentration, respectively, before autoclaving. the culture media containing macro- and microelements and vitamins were completed with carbon source and r ...	1988	3254011
effect of heavy metals on the growth of tissue cultures (ii).	the effect of toxic concentrations of three heavy metal compounds on the growth of the secondary callus tissue of nicotiana tabacum l. and ruta graveolens l. was studied. the metal compounds examined were znso4, niso4, cuso4. the metal compounds used were placed in murashige, skoog (1962) and white (1943) culture medium at 10(-6) and 10(-4) m concentration, respectively, before autoclaving. the culture media containing macro- and microelements and vitamins were completed with carbon source and r ...	1988	3254011
bacterial characteristics and follicle surface structure: their roles in peyer's patch uptake and transport of vibrio cholerae.		1988	3254071
the role of serum factors and influence of intravenous immunoglobulins on phagocytosis of campylobacter species.		1988	3255396
the effects of anions on fluid reabsorption from the proximal convoluted tubule of the rat.	1. fluid reabsorption from surface proximal tubules of the rat was measured in vivo using stationary microperfusion techniques. reabsorptive rate (jv) was measured from droplets containing chloride as the main reabsorbable anion and when chloride was substituted by bromide, iodide, nitrate, acetate, isethionate or methylsulphate in either the tubular lumen alone or in both lumen and peritubular capillaries. 2. in tubules with an intact blood supply, droplet volume decreased in a manner best desc ...	1988	3256612
hiv seropositive patients becoming seronegative.		1988	3256678
on the time-dependent diffusion of macromolecules through transient open junctions and their subendothelial spread. i. short-time model for cleft exit region.	in this two-part study we shall quantitatively study, using time-dependent models, the hypothesis that transient open junctions associated with widely scattered endothelial cells undergoing mitosis are the structural equivalent for the large pore pathway via which macromolecules the size of albumin or larger cross the vascular endothelium. in an earlier steady-state model [am. j. physiol. 248, h945-960 (1985)], the authors demonstrated that such an open-junction pathway could quantitatively acco ...	1988	3256708
a zymovar analysis of vibrio cholerae isolated in australia.	zymovar analysis was used to study 50 strains of vibrio cholerae o1 and 40 strains of v. cholerae non-o1 isolated in australia. the strains were assigned to 42 zymovars; the o1 strains to 9 types and the non-o1 strains to 33 types, with no overlapping between serovars. all the human o1 isolates, regardless of their ability to produce cholera toxin (ct), and all the ct-producing o1 environmental isolates, were type z14. the remaining o1 strains and the non-o1 strains belonged to a variety of zymo ...	1988	3256999
reticuloendothelial clearance and splenic mononuclear cell populations after resection and autotransplantation.	although the preservation of splenic tissue may prevent overwhelming infection after splenectomy, the degree of protection conferred by small remnants has not been optimal. we investigated whether either splenic reticuloendothelial clearance of a blood flow-dependent colloid or macrophage and t-cell populations might be altered by resection or autotransplantation of the spleen. our results have shown that bloodstream reticuloendothelial clearance of technetium 99m sulfur colloid is not impaired ...	1988	3257658
hydrogen peroxide-mediated inhibition of t-cell response to mitogens is a result of direct action on t cells.	hydrogen peroxide, a reactive oxygen intermediate produced by activated neutrophils, has been shown to inhibit the response of human t lymphocytes to mitogens and alloantigens. since hydrogen peroxide is known to react with iron and to induce lipid peroxidation, we compared the effects of hydrogen peroxide and a lipid peroxidation product, malondialdehyde, on the response of human peripheral blood mononuclear cells to t-cell mitogens. peripheral blood mononuclear cells pretreated with 1 mmol/l o ...	1988	3257684
inhibition of the proliferative response of human b lymphocytes to b cell growth factor by transforming growth factor-beta.	the effects of transforming growth factor-beta (tgf-beta) on the proliferative response of human b cells to the low molecular weight b cell growth factor (bcgf) have been investigated in this study. it was found that tgf-beta, at picomolar concentrations, strongly inhibited the bcgf-induced proliferation of anti-mu chain or staphylococcus aureus cowan i-activated human b cells and also of a bcgf-dependent cell line derived from a human lymphocytic nodular lymphoma. this inhibitory effect was det ...	1988	3257917
intracellular activation signal requirements for the induction of il-2 responsiveness in resting t cell subsets in humans.	activation signal requirements for the induction of the il-2 responsiveness in purified subsets of human resting t cells, t4+ or t8+, have been investigated under the monocyte-depleted conditions. substantial levels of il-2 responsiveness were induced in t8+ cells by lectin, con a, mab directed against the cd3 ag, okt3, ca2+ ionophore, ionomycin or phorbol ester, pma. in contrast, none of these stimuli was by itself sufficient for the induction of il-2 responsiveness in the t4+ subset. the latte ...	1988	3258883
t-cell-dependent eosinophilia in the cerebrospinal fluid of the mouse infected with angiostrongylus cantonensis.	eosinophilia of the cerebrospinal fluid (csf) in permissive (rats) and non-permissive (mice) hosts infected with angiostrongylus cantonensis, and the possible mechanism of the eosinophilia were studied. in three strains of thymic mice (icr, ddy and balb/c), the infection provoked a marked csf eosinophilia starting at around day 12, reaching a peak level at day 20 and maintaining significantly high levels until day 35. in contrast, in athymic nude mice of balb/c strain the infection failed to evo ...	1988	3259688
genetic, biochemical and molecular characterization of strains of vibrio cholerae multiresistant to antibiotics.	in order to gain an insight into the distribution of resistance genes in vibrio cholerae, we studied twenty-nine strains isolated from patients in africa. resistance to antibiotics in all strains except one was encoded by self-transferable plasmids belonging to incompatibility group inc6-c. tetracycline and chloramphenicol were poorly expressed in the original hosts but were easily detectable in the escherichia coli transconjugants. streptomycin resistance was due to synthesis of a 3"- or 6-amin ...	1988	3260105
the y chromosome from autoimmune bxsb/mpj mice induces a lupus-like syndrome in (nzw x c57bl/6)f1 male mice, but not in c57bl/6 male mice.	the y chromosome of the bxsb mouse has been shown to be responsible for the acceleration of lupus-like autoimmune syndrome in inbred bxsb mice and in their f1 hybrids with nzb or nzw mice. to further define the role of this as yet unidentified gene linked to the bxsb y chromosome, designated yaa (y chromosome-linked autoimmune acceleration), the y chromosome was transferred from the bxsb strain to nonautoimmune c57bl/6 (b6) mice. the effect of the yaa gene on the autoantibody formation and the d ...	1988	3260184
a comparative 1h nmr study of mouse alpha(1-53) and beta(2-53) epidermal growth factors.	the three-dimensional structure of the mouse epidermal growth factor (egf) in solution was studied by comparison of the 1h nmr spectra of alpha egf (1-53) and beta egf (2-53, des-asparaginyl 1 form). using ph dependence of chemical shifts and a two-dimensional difference spectrum, the effect of the n-terminal deletion was investigated based on the complete assignment of the proton resonances. the affected residues were all found to be located exactly in the triple-stranded, beta-sheet core in th ...	1988	3260496
a comparative 1h nmr study of mouse alpha(1-53) and beta(2-53) epidermal growth factors.	the three-dimensional structure of the mouse epidermal growth factor (egf) in solution was studied by comparison of the 1h nmr spectra of alpha egf (1-53) and beta egf (2-53, des-asparaginyl 1 form). using ph dependence of chemical shifts and a two-dimensional difference spectrum, the effect of the n-terminal deletion was investigated based on the complete assignment of the proton resonances. the affected residues were all found to be located exactly in the triple-stranded, beta-sheet core in th ...	1988	3260496
human basophilic cell differentiation promoted by 2.5s nerve growth factor.	in liquid cultures of human cord blood mononuclear cells, the activities of the 2.5s nerve growth factor (ngf) inducing basophil and eosinophil differentiation were investigated. various concentrations of immunopurified 2.5s ngf derived from murine submaxillary glands were added to cultures with or without conditioned medium from a human t cell line (mo-cm), which has previously been shown to produce activities stimulating granulocyte-macrophage colonies. addition of ngf led to significant incre ...	1988	3261719
anterior and posterior axial lens displacement and human aqueous outflow facility.	we studied the effect of anterior and posterior axial crystalline lens displacement (and thereby ciliary tone) on the aqueous humor outflow facility in enucleated human eyes. after attaching a reversible footplate plunger to the anterior lens capsule with cyanoacrylate, the lens was placed in one of three positions: "neutral baseline," posterior displacement (2.5 mm), or anterior displacement (2.0 mm). in seven pairs of eyes, the mean "neutral baseline" was not statistically different from the c ...	1988	3262095
anterior and posterior axial lens displacement and human aqueous outflow facility.	we studied the effect of anterior and posterior axial crystalline lens displacement (and thereby ciliary tone) on the aqueous humor outflow facility in enucleated human eyes. after attaching a reversible footplate plunger to the anterior lens capsule with cyanoacrylate, the lens was placed in one of three positions: "neutral baseline," posterior displacement (2.5 mm), or anterior displacement (2.0 mm). in seven pairs of eyes, the mean "neutral baseline" was not statistically different from the c ...	1988	3262095
scaffolding protein regulates the polymerization of p22 coat subunits into icosahedral shells in vitro.	coat and scaffolding subunits derived from p22 procapsids have been purified in forms that co-assemble rapidly and efficiently into icosahedral shells in vitro under native conditions. the half-time for this reaction is approximately five minutes at 21 degrees c. the in vitro reaction exhibits the regulated features observed in vivo. neither coat nor scaffolding subunits alone self-assemble into large structures. upon mixing the subunits together they polymerize into procapsid-like shells with t ...	1988	3262767
thrombotic thrombocytopenia with von willebrand factor deficiency induced by botrocetin. an animal model.	thrombotic thrombocytopenia with severe von willebrand factor (vwf) depletion was induced in rats by intraperitoneal injection of botrocetin, a bothrops factor requiring vwf for platelet aggregation. the vwf deficiency state with thrombocytopenia was produced in 12 animals by single or multiple injections of botrocetin. single botrocetin injection (450 units/kg) reduced plasma vwf activity to less than 0.01 mu/ml for 24 hours and less than 0.2 units/ml up to 72 hours. during this period, multime ...	1988	3262788