Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| sexual violence, hsv-2 and hiv are important predictors for infertility in rwanda. | in order to formulate cost-effective health interventions aimed at preventing infertility it is necessary to identify modifiable risk factors for infertility in sub-saharan africa. this case-control study examined potential predictors and their population attributable fraction (paf%) for various infertility types including lifestyle factors, sexual behaviour and reproductive tract infections (rtis). | 2010 | 20685757 |
| anti-herpes simplex virus effects of berberine from coptidis rhizoma, a major component of a chinese herbal medicine, ching-wei-san. | berberine is an alkaloid extracted from coptidis rhizome. among the individual herbal components of a chinese herb medicine, ching-wei-san, coptidis rhizoma has the most potent antimicrobial activity. by high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/ml (w/v) coptidis rhizome extract or 50.00-mg/ml (w/v) ching-wei-san was determined to be 0.26 mg/ml. to explore the potential use of ching-wei-san against herpes simplex virus (hsv) infection, the cytotoxic ... | 2010 | 20686799 |
| intravaginal infection with herpes simplex virus type-2 (hsv-2) generates a functional effector memory t cell population that persists in the murine genital tract. | although the female genital tract is the main portal of entry for sexually transmitted infections in women, we still have limited understanding of the generation, maintenance and characteristics of memory t cells in the local tissue. here, we utilized a mouse model of intravaginal hsv-2 infection and tetramers against the immunodominant hsv glycoprotein b epitope recognized by cd8+ t cells to examine the generation, maintenance and characteristics of anti-hsv memory t cells in the genital tract ... | 2010 | 20688399 |
| infection of porcine cells with human herpesviruses. | porcine organs are valuable candidate materials for xenotransplantation to humans. long-term maintenance of well functioning transplants is a prerequisite for success. transplanted organs may be damaged by immune reactions or by infectious agents in hosts. human herpesviruses (hhvs) establish life-long latency in humans after a primary infection. they can be reactivated with various stimuli, including immunosuppression. this study was performed to verify the infectivity of some hhvs toward porci ... | 2010 | 20692426 |
| detailed characterization of t cell responses to herpes simplex virus-2 in immune seronegative persons. | in 2003, we described a small cohort of subjects (n = 6) who possessed no detectable serum abs to hsv-1 or hsv-2 and no clinical or virological evidence of mucosal hsv infection yet possessed consistently detectable hsv-specific t cell responses measured primarily by lymphoproliferative (lp) and ctl assays to whole hsv-2 ag. we termed these persons immune seronegative (is). this report characterizes the t cell responses in 22 is subjects largely recruited from studies of hsv-seronegative subject ... | 2010 | 20164419 |
| recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy. | a mouse model of recurrent herpes simplex type 2 (hsv-2) would improve our understanding of the immunobiology of recurrent disease and provide a useful model for evaluating antiviral treatments. we developed a model to evaluate recurrent vaginal hsv-2 shedding using high-dose acyclovir (acv) therapy beginning at 3 days post infection (dpi). treatment with 150mg/kg of acv for 10 days increased survival to 80% following vaginal challenge with hsv-2 strain 186 and to 100% after challenge with strai ... | 2010 | 20167236 |
| in vivo requirement for atg5 in antigen presentation by dendritic cells. | autophagy is known to be important in presentation of cytosolic antigens on mhc class ii (mhc ii). however, the role of autophagic process in antigen presentation in vivo is unclear. mice with dendritic cell (dc)-conditional deletion in atg5, a key autophagy gene, showed impaired cd4(+) t cell priming after herpes simplex virus infection and succumbed to rapid disease. the most pronounced defect of atg5(-/-) dcs was the processing and presentation of phagocytosed antigens containing toll-like re ... | 2010 | 20171125 |
| the glycoproteins c and g are equivalent target antigens for the determination of herpes simplex virus type 1-specific antibodies. | seroreactivity to the glycoproteins c and g of herpes simplex virus type 1 (hsv-1) was compared in 310 serum samples using a western blot assay containing a whole antigen extract of hsv-1 and an elisa employing gc1 isolated from hsv-1. the prevalence of reactivity to gc1 was 75.8% by western blot and 73.9% by elisa, while antibody responses to gg1 were detected in 72.9% of sera by western blot. an absolute correlation of 96.1% between the reactivity to gc1 and gg1 was demonstrated using the west ... | 2010 | 20171247 |
| distinct effects of knocking down mek1 and mek2 on replication of herpes simplex virus type 2. | during infection, viruses hijack various host cell components and programs for their amplification, among which is the canonical erk signaling pathway, mainly consisting of three tiered serine/threonine kinases, raf, mek and erk. mek1 and mek2 are two isoforms of the kinase operating immediately upstream of erk, and connecting raf and erk by phosphorylating erk. previous studies have suggested that different isoforms of mek have distinct biological functions, although their in vitro kinase funct ... | 2010 | 20172001 |
| a highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (pi-88) exhibits virucidal activity against herpes simplex virus. | although sulfated polysaccharides potently inhibit the infectivity of herpes simplex virus (hsv) and human immunodeficiency virus in cultured cells, these compounds fail to show protective effects in humans, most likely due to their poor virucidal activity. herein we report on sulfated oligosaccharide glycosides related to muparfostat (formerly known as pi-88) and their assessment for anti-hsv activity. chemical modifications based on the introduction of specific hydrophobic groups at the reduci ... | 2010 | 20176055 |
| determinants of hiv type 1 shedding from genital ulcers among men in south africa. | our study evaluated correlates of human immunodeficiency virus (hiv)-1 lesional shedding among men with genital ulcer disease (gud). | 2010 | 20178417 |
| chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child. | a unique form of chronic, active, granulomatous herpes simplex type 2 encephalitis is described in an asymptomatic, immunocompetent 8-year-old girl who acquired the virus as a neonate. the extensive, bilateral cerebral parenchymal involvement was discovered incidentally. diagnosis was confirmed by a combination of serial neuroimaging, brain biopsy, and quantitative polymerase chain reaction targeted to dna sequences in the glycoprotein g gene, allowing differentiation between herpes simplex viru ... | 2010 | 20179002 |
| numerous conserved and divergent micrornas expressed by herpes simplex viruses 1 and 2. | certain viruses use micrornas (mirnas) to regulate the expression of their own genes, host genes, or both. previous studies have identified a limited number of mirnas expressed by herpes simplex viruses 1 and 2 (hsv-1 and -2), some of which are conserved between these two viruses. to more comprehensively analyze the mirnas expressed by hsv-1 or hsv-2 during productive and latent infection, we applied a massively parallel sequencing approach. we were able to identify 16 and 17 mirnas expressed by ... | 2010 | 20181707 |
| the term newborn potentially exposed to herpes simplex virus. | 2010 | 20122480 | |
| low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy. | human herpesviruses, e.g., herpes simplex virus (hsv) type 1, epstein-barr virus, and cytomegalovirus, appear in saliva at greater frequency in persons infected with human immunodeficiency virus (hiv) than in healthy individuals. however, it is not known if varicella zoster virus (vzv) and hsv-2 appear simultaneously during hiv infection at greater frequency in saliva in this era of highly active antiretroviral therapy (haart). the aim of this study was to investigate the prevalence and amounts ... | 2010 | 20123407 |
| causes of acute hospitalization in adolescence: burden and spectrum of hiv-related morbidity in a country with an early-onset and severe hiv epidemic: a prospective survey. | survival to older childhood with untreated, vertically acquired hiv infection, which was previously considered extremely unusual, is increasingly well described. however, the overall impact on adolescent health in settings with high hiv seroprevalence has not previously been investigated. | 2010 | 20126383 |
| solvent-induced virus inactivation by acidic arginine solution. | viral clearance is a primary concern for parenteral protein biopharmaceuticals. low ph, detergent/solvent wash, or heating, called pasteurization, has been the main process for virus inactivation. detergent/solvent wash is also used to treat superficial infectious diseases, including herpes simplex virus (hsv) infections. herein we examined virus inactivation effects of acidic arginine on hsv type 2 (hsv-2) as a function of ph and temperature in an attempt to find solvent conditions that are eff ... | 2010 | 20127049 |
| construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an hsv-1 virion host shutoff protein. | the replication-defective herpes simplex virus 2 (hsv-2) dl5-29 mutant virus strain with deletions in the u(l)5 and u(l)29 genes has been shown to protect mice and guinea pigs against challenge with wild-type (wt) hsv-2 and to protect against ocular disease caused by hsv-1 infection. the dl5-29 strain is currently being prepared for clinical trials as a herpes vaccine candidate. as a possible approach to improve the efficacy of dl5-29 as a genital herpes vaccine, we replaced the u(l)41 gene enco ... | 2010 | 20117270 |
| synthesis and antiviral activity of phthiobuzone analogues. | a series of phthiobuzone analogs, prepared from potassium phthalimide or phthalandione, have been evaluated for their antiviral activities. among the candidates, compounds 5j and 5k, which contain the substituted 4-halogenated phenyl ring at n-4',4'' position, show more potent antiviral activity than phthiobuzone against herpes simplex virus 1 (ic(50)=8.56 and 2.85 microg/ml, respectively) and herpes simplex virus 2 (ic(50)=1.75 and 4.11 microg/ml, respectively). compounds 9c and 9d with a propy ... | 2010 | 20118580 |
| design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents. | based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. the synthesized 3'-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, hsv-1, hsv-2 and hiv. | 2010 | 20195818 |
| cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli. | h2o2 produced by vaginal lactobacilli is believed to protect against infection, and h2o2-producing lactobacilli inactivate pathogens in vitro in protein-free salt solution. however, cervicovaginal fluid (cvf) and semen have significant h2o2-blocking activity. | 2010 | 20482854 |
| a 12-year molecular survey of clinical herpes simplex virus type 2 isolates demonstrates the circulation of clade a and b strains in germany. | recently two different herpes simplex virus type 2 (hsv-2) clades (a and b) were described on dna sequence data of the glycoprotein e (ge), g (gg) and i (gi) genes. | 2010 | 20488747 |
| brainstem encephalitis: an unusual presentation of herpes simplex virus infection. | herpes simplex virus (hsv) encephalitis has a predilection for the temporal and frontal lobes but occasionally affects the brainstem. we describe a patient who developed hsv brainstem encephalitis that progressed to quadriplegia. using medline, we conducted a comprehensive review of other published cases of hsv brainstem encephalitis. twenty-four published cases of hsv brainstem encephalitis met our inclusion criteria. the mean age was 41.4 years (range 18-71). hsv-1 was the etiologic agent in 7 ... | 2010 | 20495814 |
| construction of, and t-helper (th)1/th2 immune responses to, a herpes simplex virus type 2 glycoprotein d-cytotoxic t-lymphocyte epitope dna vaccine. | recombinant cytotoxic t lymphocyte (ctl) epitope dna vaccines offer an attractive approach for the induction of robust cellular and humoral immune responses directed against human pathogen target antigens. | 2010 | 20497188 |
| rapid polymerase chain reaction assay to detect herpes simplex virus in the genital tract of women in labor. | to develop a rapid quantitative real-time polymerase chain reaction (pcr) to detect herpes simplex virus (hsv) in the genital secretions of women that may be used in labor. | 2010 | 20502292 |
| racial/ethnic disparities in undiagnosed infection with herpes simplex virus type 2. | herpes simplex virus type 2 (hsv-2) is a common sexually transmitted infection (sti) that is the main cause of genital herpes. studies have found racial/ethnic disparities in hsv-2 prevalence, but there have been few studies of racial/ethnic differences in the proportion of infections that go without a genital herpes diagnosis. | 2010 | 20502391 |
| etiology and sti/hiv coinfections among patients with urethral and vaginal discharge syndromes in south africa. | this study was undertaken to establish the etiology of the male urethral discharge (muds) and vaginal discharge (vds) syndromes, to determine the prevalence of other sexually transmitted infections (sti) and human immunodeficiency virus (hiv) coinfections, and to examine associations between stis and hiv serostatus among sti patients in south africa. | 2010 | 20502394 |
| herpes simplex virus infects skin gamma delta t cells before langerhans cells and impedes migration of infected langerhans cells by inducing apoptosis and blocking e-cadherin downregulation. | the role individual skin dendritic cell (dc) subsets play in the immune response to hsv remains unclear. we investigated the effect of hsv on dc virus uptake, viability, and migration after cutaneous infection in vitro and in vivo. hsv increased the emigration of skin dcs from whole skin explants over 3 d postinfection (p.i.) compared with mock controls, but the kinetics of emigration was influenced by the skin dc subset. uninfected (bystander) langerhans cells (lcs) were the major emigrant dc s ... | 2010 | 20519652 |
| immunization with a dominant-negative recombinant herpes simplex virus (hsv) type 1 protects against hsv-2 genital disease in guinea pigs. | cj9-gd is a novel dominant-negative recombinant herpes simplex virus type 1 (hsv-1) that is completely replication-defective, cannot establish detectable latent infection in vivo, and expresses high levels of the major hsv-1 antigen glycoprotein d immediately following infection. in the present study, cj9-gd was evaluated as a vaccine against hsv-2 genital infection in guinea pigs. | 2010 | 20525279 |
| aspects of human disease: 48. herpesvirus infections. | 2010 | 20527503 | |
| even nhanes evolves: some surprising findings about women who have sex with women. | 2010 | 20531028 | |
| prevalence- and gender-specific immune response to opportunistic infections in hiv-infected patients in lesotho. | the objective of this study was to assess the seroprevalence of coinfecting viruses and treponema pallidum (t. pallidum) in a cohort of 205 antiretrovirally treated hiv-infected individuals (152 females and 53 males, aged: 19-71 years) in rural lesotho. furthermore agent-specific immune responses were investigated by analyzing antibody titers against herpes simplex virus type 2 (hsv-2) and against t. pallidum. | 2010 | 20531031 |
| women who have sex with women in the united states: prevalence, sexual behavior and prevalence of herpes simplex virus type 2 infection-results from national health and nutrition examination survey 2001-2006. | to estimate the prevalence of same-sex sexual behavior in women in the united states; to describe demographic and behavioral characteristics and the prevalence of herpes simplex virus type 2 (hsv-2) infection. | 2010 | 20531032 |
| asp2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2. | to evaluate and describe the anti-herpesvirus effect of asp2151, amenamevir, a novel non-nucleoside oxadiazolylphenyl-containing herpesvirus helicase-primase complex inhibitor. | 2010 | 20534624 |
| apoptosis induction after herpes simplex virus infection differs according to cell type in vivo. | we compared apoptosis induction in mice following three routes of infection. after intravenous infection, wild-type herpes simplex virus (hsv) types 1 and 2 and us3delta mutants infected the adrenal gland and caused apoptosis. corneal infection with wild-type virus resulted in apoptosis in a fraction of infected epithelium cells. interestingly, many uninfected cells were apoptotic in the retina. although neurons in the trigeminal ganglion were heavily infected, no apoptotic neurons were observed ... | 2010 | 20535504 |
| heterosexual hiv-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. | high plasma hiv-1 rna concentrations are associated with increased risk of hiv-1 transmission. initiation of antiretroviral therapy (art) reduces plasma hiv-1 concentrations. we aimed to assess the effect of art use by patients infected with hiv-1 on risk of transmission to their uninfected partners. | 2010 | 20537376 |
| modern management of genital ulcer disease-frappez fort et frappez vite. | 2010 | 20539259 | |
| genital ulcer disease treatment policies and access to acyclovir in eight sub-saharan african countries. | herpes simplex virus-2, the most common cause of genital ulcer disease (gud) globally, is a cofactor in human immunodeficiency virus type-1 (hiv-1) acquisition and transmission. current world health organization guidelines for sexually transmitted infections recommend acyclovir as first-line syndromic treatment of gud in countries with high herpes simplex virus-2 prevalence (> or =30%). | 2010 | 20539260 |
| contribution of sexually transmitted infections to the sexual transmission of hiv. | we review recent evidence about the link between sexually transmitted infections (sti) and hiv transmission and consider implications for control programmes. | 2010 | 20543605 |
| long-term biological and behavioural impact of an adolescent sexual health intervention in tanzania: follow-up survey of the community-based mema kwa vijana trial. | the ability of specific behaviour-change interventions to reduce hiv infection in young people remains questionable. since january 1999, an adolescent sexual and reproductive health (srh) intervention has been implemented in ten randomly chosen intervention communities in rural tanzania, within a community randomised trial (see below; nct00248469). the intervention consisted of teacher-led, peer-assisted in-school education, youth-friendly health services, community activities, and youth condom ... | 2010 | 20543994 |
| epstein-barr virus in bone marrow of rheumatoid arthritis patients predicts response to rituximab treatment. | viruses may contribute to ra. this prompted us to monitor viral load and response to anti-cd20 therapy in ra patients. | 2010 | 20547657 |
| high efficiency preparation of bioactive human alpha-defensin 6 in escherichia coli origami(de3)plyss by soluble fusion expression. | human alpha-defensin 6 (hd(6)), a small cysteine-rich cationic peptide specially expressed in epithelial cells of digestive tract, may play a crucial role in mucosal immunity. this is the first report on efficient production of bioactive hd(6) through a gene-engineering approach in escherichia coli. the recombinant plasmid pet32a-omhd(6) was primarily constructed by inserting a pcr fragment encoding mature hd(6) peptide (mhd(6)) preceded by an enterokinase recognition sequence into the expressio ... | 2010 | 20549202 |
| intimate partner violence, relationship power inequity, and incidence of hiv infection in young women in south africa: a cohort study. | cross-sectional studies have shown that intimate partner violence and gender inequity in relationships are associated with increased prevalence of hiv in women. yet temporal sequence and causality have been questioned, and few hiv prevention programmes address these issues. we assessed whether intimate partner violence and relationship power inequity increase risk of incident hiv infection in south african women. | 2010 | 20557928 |
| recurrent herpes simplex virus type 2 meningitis in elderly persons. | to review the ages of patients with recurrent herpes simplex virus type 2 (hsv-2) meningitis. | 2010 | 20558398 |
| making the case for circumcision as a public health strategy: opening the dialogue. | hispanics in the united states have lower rates of male circumcision and higher rates of hiv. although mc has been demonstrated to reduce the risk of acquisition of several sexual transmitted diseases such as hiv, human papilloma virus infection, and herpes simplex virus type 2, mc is only medically reimbursable by insurance for adults or children following recurrent infection, injury, or malformation of the penis. we conducted two studies of attitudes regarding mc among health care providers to ... | 2010 | 20565321 |
| in vitro antiherpes effects of a c-glycosylflavonoid-enriched fraction of cecropia glaziovii sneth. | to investigate the in vitro antiherpes effects of the crude aqueous extract obtained from cecropia glaziovii leaves and their related fractions, the n-butanol fraction (n-buoh) and the c-glycosylflavonoid-enriched fraction (meoh(amb)), and to determine the viral multiplication step(s) upon which this c-glycosylflavonoid-enriched fraction acts. | 2010 | 20572924 |
| the ig-like v-type domain of paired ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion. | paired immunoglobulin (ig)-like type 2 receptor alpha (pilralpha) and pilrbeta are paired receptors that are highly homologous to each other. when engaged by ligand, pilralpha is inhibitory whereas pilrbeta is activating. pilralpha is a newly identified herpes simplex virus type 1 (hsv-1) glycoprotein b (gb) receptor and is associated with membrane fusion and entry activity of hsv-1. pilralpha is a 303-amino-acid protein with an ig-like v (variable)-type domain from amino acid 31 to 150, whereas ... | 2010 | 20573830 |
| alcohol use, sexual risk behavior and stis among married men in mumbai, india. | this paper examines the relationship of frequency, type of alcohol use, sexual risk behaviors and sexually transmitted infections (stis) among married men living in economically marginal communities in mumbai, india. the findings indicate that men who consume alcohol daily were four times more likely to have had extramarital sex in the past 12 months. in terms of sexually transmitted infections, men who were daily drinkers were four times more likely than those not consuming alcohol in the last ... | 2010 | 20574637 |
| a short polypeptide from the herpes simplex virus type 2 icp10 gene can induce antigen aggregation and autophagosomal degradation for enhanced immune presentation. | it has been reported that certain polypeptides derived from aggregation-prone cellular proteins can turn soluble green fluorescent protein (gfp) into aggregates. here we report our finding that a short peptide derived from a viral gene, icp10 of herpes simplex virus (hsv)-2, also possesses such a property. a sequence as short as 13 amino acids from the middle region of the gene can convert gfp into an aggregation-prone toxic protein once it is fused to the c terminus. moreover, this short peptid ... | 2010 | 20583863 |
| increased levels of immune activation in the genital tract of healthy young women from sub-saharan africa. | to determine whether healthy, young women in sub-saharan africa have a more activated immune milieu in the genital tract (i.e. activated cd4 t cells) than a similar population in the united states. | 2010 | 20588163 |
| herpes simplex virus type 2 enhances hiv-1 susceptibility by affecting langerhans cell function. | genital herpes is the most prevalent viral sexually transmitted infection worldwide and is mainly caused by hsv type 2 (hsv-2). hsv-2 infection enhances hiv-1 susceptibility, even in the absence of clinical symptoms. in this study, we investigated the effect of hsv-2 on hiv-1 transmission by mucosal langerhans cells (lcs). lcs are important in heterosexual transmission because they form a barrier against hiv-1 infection; lcs efficiently capture and degrade hiv-1 through the c-type lectin langeri ... | 2010 | 20592277 |
| hepatitis b infection and association with other sexually transmitted infections among men who have sex with men in peru. | to assess the epidemiology of hepatitis b virus (hbv) infection among men who have sex with men (msm) in peru, we evaluated the prevalence and associated risk factors for hbv serologic markers among participants of a hiv sentinel surveillance conducted in 2002-2003. the standardized prevalences for total antibodies to hepatitis b core antigen (anti-hbc) and hepatitis b surface antigen (hbsag) were 20.2% and 2.8%, respectively. individuals with human immunodeficiency virus (hiv-1) infection had s ... | 2010 | 20595501 |
| a danish national birth cohort study of maternal hsv-2 antibodies as a risk factor for schizophrenia in their offspring. | several studies have implicated early infections, including maternal infection with herpes simplex virus 2 (hsv-2), as an environmental risk factor for schizophrenia. | 2010 | 20598509 |
| herpes simplex virus type 2 glycoprotein e is required for efficient virus spread from epithelial cells to neurons and for targeting viral proteins from the neuron cell body into axons. | the hsv-2 lifecycle involves virus spread in a circuit from the inoculation site to dorsal root ganglia and return. we evaluated the role of ge-2 in the virus lifecycle by deleting amino acids 124-495 (ge2-del virus). in the mouse retina infection model, ge2-del virus does not spread to nuclei in the brain, indicating a defect in anterograde (pre-synaptic to post-synaptic neurons) and retrograde (post-synaptic to pre-synaptic neurons) spread. infection of neuronal cells in vitro demonstrates tha ... | 2010 | 20598729 |
| crystal structure of the conserved herpesvirus fusion regulator complex gh-gl. | herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gb and the heterodimer gh-gl, plus other nonconserved components. gb is a class iii viral fusogen, but unlike other members of its class, it does not function alone. we determined the crystal structure of the gh ectodomain bound to ... | 2010 | 20601960 |
| incidence of multiple herpesvirus infection in hiv seropositive patients, a big concern for eastern indian scenario. | human immunodeficiency virus (hiv) infection is associated with an increased risk for human herpes viruses (hhvs) and their related diseases and they frequently cause disease deterioration and therapeutic failures. methods for limiting the transmission of hhvs require a better understanding of the incidence and infectivity of oral hhvs in hiv-infected patients. this study was designed to determine the seroprevalence of human herpes viruses (cmv, hsv 2, ebv-1, vzv) antibodies and to evaluate thei ... | 2010 | 20604948 |
| herpes esophagitis in healthy adults and adolescents: report of 3 cases and review of the literature. | herpes esophagitis (he) is common in immunosuppressed patients, but has rarely been reported in immunocompetent individuals, in whom it appears to be a self-limited illness. we describe 3 new cases of he in otherwise healthy patients seen in our hospital within the last 5 years. we performed a comprehensive review of the previously reported cases of he in immunocompetent adults and adolescents in the english and spanish literature. we analyzed the clinical features, treatment, and outcome of thi ... | 2010 | 20616659 |
| rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in hiv-infected adults. | to determine whether rapidly cleared episodes of herpes simplex virus (hsv) reactivation occur in hiv-infected adults. | 2010 | 20616743 |
| presence of human papilloma virus, herpes simplex virus and epstein-barr virus dna in oral biopsies from sudanese patients with regard to toombak use. | using pcr/dna sequencing, we investigated the prevalence of human papillomavirus (hpv), herpes simplex virus (hsv) and epstein-barr virus (ebv) dna in brush biopsies obtained from 150 users of sudanese snuff (toombak) and 25 non-users of toombak in formalin-fixed paraffin-embedded tissue samples obtained from 31 patients with oral dysplasias (25 toombak users and 6 non-users), and from 217 patients with oral cancers (145 toombak users and 72 non-users). in the brush tissue samples from toombak u ... | 2010 | 20618612 |
| [a man with a painful finger]. | a 34-year-old man presented with a recurring painful inflammation of his left middle finger, caused by a herpes simplex type 2 infection. | 2010 | 20619012 |
| treatment of hiv infection with drugs for hsv-2 infection. | 2010 | 20621229 | |
| association of hsv reactivation and pro-inflammatory cytokine levels with the severity of stomatitis after beam chemotherapy and autologous sct. | background: stomatitis, including oral mucositis and ulcerations induced by hsv-reactivation are major sources of morbidity after high-dose (hd) chemotherapy and subsequent autologous hematopoietic stem cell transplantation (sct). while increased synthesis of pro-inflammatory cytokines, such as interleukin-1 (il-1) and tumor necrosis factor alpha (tnf-alpha)-as well as reactivation of viral infections have frequently been observed in this setting, data on their association with the severity of m ... | 2010 | 20623145 |
| diversity in cd8(+) t cell function and epitope breadth among persons with genital herpes. | cd8(+) t cells are known to be important in clearing herpes simplex virus (hsv) infections. however, investigating the specific antiviral mechanisms employed by hsv-2-specific t cell populations is limited by a lack of reagents such as cd8(+) t cell epitopes and specific tetramers. using a combination of intracellular cytokine staining flow cytometry and elispot methods, we functionally characterized peripheral hsv-2-specific cd8(+) t cells from peripheral blood mononuclear cell (pbmc) that reco ... | 2010 | 20635156 |
| a new multiplex real-time pcr test for hsv1/2 and syphilis: an evaluation of its impact in the laboratory and clinical setting. | to develop, evaluate and implement a new multiplex real-time pcr test for the detection of herpes simplex virus (hsv)1, hsv2 and syphilis in a single sample using a single test. | 2010 | 20643660 |
| effect of acyclovir on hiv-1 set point among herpes simplex virus type 2-seropositive persons during early hiv-1 infection. | we evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (hiv-1) acquisition reduces hiv-1 set point, increases cd4 cell counts, and selects reverse-transcriptase mutations among 76 hiv-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of hiv acquisition in herpes simplex virus type 2 (hsv-2)-seropositive persons (hiv prevention trials network study 039). we found no significant difference in plasma hiv-1 r ... | 2010 | 20649426 |
| pathogenesis of primary acquired nasolacrimal duct obstruction. | to assess the factors assumed to be contributed in pathogenesis of primary acquired nasolacrimal duct obstruction (pando). | 2010 | 20302403 |
| lipophile-conjugated sulfated oligosaccharides as novel microbicides against hiv-1. | with the aim of providing compounds suitable for further development as microbicides active against human immunodeficiency virus 1 (hiv-1) a library containing 37 lipophile-conjugated sulfated oligosaccharides was screened for antiviral and virucidal activity against this virus. four highly active compounds had low drug inhibition concentrations (ic(50)) for hiv-1 and inactivated viral particles, suggestive of virucidal properties. two of these compounds comprising a sulfated tetrasaccharide lin ... | 2010 | 20307578 |
| seroprevalence of human herpes simplex, hepatitis b and epstein-barr viruses in children with acute lymphoblastic leukemia in southern iran. | to investigate the seroprevalence of herpes simplex viruses (hsv1 and hsv2), ebstein-barr virus (ebv) and hepatitis b virus (hbv) in children with acute lymphoblastic leukemia (all) in southern iran. 90 patients with all and 90 age-sex matched healthy participants were enrolled in this study. antibodies (igg) against hbsag, hsv1, hsv2, ebv different antigens including epstein-barr nuclear antigen-1 (ebna-1), viral capsid antigen (vca) and early antigen (ea) were measured by enzyme-linked immunos ... | 2010 | 20309661 |
| head and neck squamous cell carcinomas in hiv-positive patients: a preliminary investigation of viral associations. | oncogenic human papillomaviruses (hpvs) are associated with oropharyngeal squamous cell carcinoma (scc). infection with human immunodeficiency virus (hiv) increases susceptibility to opportunistic infections and viral-promoted cancers. the prevalences of hpv, herpes simplex virus (hsv), epstein-barr virus (ebv), and human herpesvirus-8 (hhv-8) have not been established for head and neck squamous cell carcinoma in hiv-positive patients (hiv+ hnscc). we have observed that hiv+ hnscc tend to contai ... | 2010 | 20333562 |
| [establishment of a cell model system of herpes simplex virus type ii latent infection and reactivation in sh-sy5y cells]. | to establish an experimental culture system of herpes simplex virus type ii (hsv-2) latent infection and reactivation in sh-sy5y cells. | 2010 | 20344947 |
| association of autism with polyomavirus infection in postmortem brains. | autism is a highly heritable behavioral disorder. yet, two decades of genetic investigation have unveiled extremely few cases that can be solely explained on the basis of de novo mutations or cytogenetic abnormalities. vertical viral transmission represents a nongenetic mechanism of disease compatible with high parent-to-offspring transmission and with low rates of disease-specific genetic abnormalities. vertically transmitted viruses should be found more frequently in the affected tissues of au ... | 2010 | 20345322 |
| population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2. | the continuation of developing herpes simplex virus type-2 (hsv-2) prophylactic vaccines requires parallel mathematical modeling to quantify the effect on the population of these vaccines. | 2010 | 20351622 |
| new analogues of acyclovir--synthesis and biological activity. | new acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2). the influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. the esters were synthesized using the coupling reagents n-ethyl-n'-(3-dimethylaminopropyl)carbodiimide hydrochloride (edc) and n,n-dimethyl-4-aminopyridine (dmap) as a catalyst. | 2010 | 20355317 |
| immunostimulating effects of a sulfated galactan from codium fragile. | a pyruvylated sulfated galactan from codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal d-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. this particular polysaccharide was found to stimulate the production of nitric oxide by inducing inos at the mrna and protein levels. in addition, the polysaccharide also induced several cytokine mrna expressions such as il ... | 2010 | 20362278 |
| [inactivated herpes simplex virus types 1 and 2 divaccine as an agent for effective immunoprophylaxis of recurrent genital herpes]. | prevention of recurrent genital herpes with the inactivated herpetic divaccine vitaherpavac against herpes simplex virus types 1 and 2 has a number of advantages over the most commonly used symptomatic therapy: it ceases or significantly reduces the number of recurrences and accordingly prolongs a relapse-free interval, abolishes viremia and the manifestations of clinical symptoms of recurrences, induces no dependence to the vaccine. coadministration of the vitaherpavac vaccine and the immunomod ... | 2010 | 20364670 |
| a rare case of absent corpus callosum with severe ventriculomegaly due to congenital herpes simplex infection. | 2010 | 20373944 | |
| toll-like receptor 3 immune deficiency may be causative for hsv-2-associated mollaret meningitis. | 2010 | 20375513 | |
| effectiveness of hiv prevention for youth in sub-saharan africa: systematic review and meta-analysis of randomized and nonrandomized trials. | systematically assess the effectiveness of hiv-prevention interventions in changing sexual behaviour of young people (10-25 years) in sub-saharan africa. | 2010 | 20375876 |
| religious involvement and seroprevalence of six infectious diseases in us adults. | in the united states, religious practice is inversely associated with several chronic conditions, but no reports show whether it is inversely associated with prevalence of positive serology for infections. | 2010 | 20375957 |
| clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers. | the natural history of hsv-2 infection and role of hsv-2 reactivations in hiv disease progression are unclear. | 2010 | 20376310 |
| type-specific cervico-vaginal human papillomavirus infection increases risk of hiv acquisition independent of other sexually transmitted infections. | sexually transmitted infections (stis) such as herpes simplex virus (hsv)-2 are associated with an increased risk of hiv infection. human papillomavirus (hpv) is a common sti, but little is know about its role in hiv transmission. the objective of this study was to determine whether cervico-vaginal hpv infection increases the risk of hiv acquisition in women independent of other common stis. | 2010 | 20386706 |
| chronic viral infection and primary central nervous system malignancy. | primary central nervous system (cns) tumors cause significant morbidity and mortality in both adults and children. while some of the genetic and molecular mechanisms of neuro-oncogenesis are known, much less is known about possible epigenetic contributions to disease pathophysiology. over the last several decades, chronic viral infections have been associated with a number of human malignancies. in primary cns malignancies, two families of viruses, namely polyomavirus and herpesvirus, have been ... | 2010 | 20387126 |
| male sex workers in moscow, russia: a pilot study of demographics, substance use patterns, and prevalence of hiv-1 and sexually transmitted infections. | the russian federation has been undergoing a concentrated epidemic of hiv-1 with high rates of infection among injecting drug users. less is known about the relative risk and contribution to the country's hiv epidemic by other at-risk populations including sex workers and men who have sex with men. the goals of this project were to explore demographic characteristics, substance use patterns, and estimate the prevalence of sexually transmitted infections (stis) and high-risk behaviors among male ... | 2010 | 20390488 |
| abundant expression of hiv target cells and c-type lectin receptors in the foreskin tissue of young kenyan men. | a biological explanation for the reduction in hiv-1 (hiv) acquisition after male circumcision may be that removal of the foreskin reduces the number of target cells for hiv. the expression of potential hiv target cells and c-type lectin receptors in foreskin tissue of men at risk of hiv infection were thus analyzed. thirty-three foreskin tissue samples, stratified by herpes simplex virus type 2 status, were obtained from a randomized, controlled trial conducted in kenya. the samples were analyze ... | 2010 | 20395432 |
| anti-hsv activity of camptothecin analogues. | in order to explore the range of biological activities of the camptothecin compound class, the in vitro antiviral efficacies of series i-iv of representative members from camptothecin analogues on herpes simplex virus type 2 (hsv-2) were evaluated on vero cells. several compounds exhibited similar or better antiviral activity against hsv-2 in vitro than acyclovir. among them, compound 6 showed the highest anti-hsv-2 activity, with ic(50) values of 1.3 microg ml(-1) and si values of 27.04, respec ... | 2010 | 20397103 |
| recurrent meningitis attributable to herpes simplex virus-2 in a child. | a boy manifested episodes of recurrent meningitis that were attributed to herpes simplex virus-2 infection. he presented no concurrent or previous history of involvement of the genitourinary system. he exhibited headaches, dizziness, photophobia, loss of balance, and vomiting. he underwent three episodes of aseptic meningitis. the herpes simplex virus-2 etiology was confirmed by polymerase chain reaction of the cerebrospinal fluid in the last two episodes. after the third occurrence, he was trea ... | 2010 | 20399396 |
| seroprevalence of herpes simplex virus-2 in kidney transplant recipients: a single-center experience. | viral infections are a real threat in kidney transplant recipients because of their immunocompromised condition. this study aimed to evaluate herpes simplex virus-2 (hsv-2) seropositivity among kidney transplant recipients. | 2010 | 20404429 |
| herpes infects one in six in united states. | 2010 | 20405533 | |
| apoe genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding. | apolipoprotein e is polymorphic in the human population. apoe4 has previously been reported to correlate with symptomatic oral and genital herpes disease. | 2010 | 20410080 |
| characterization of structures and antiviral effects of polysaccharides from portulaca oleracea l. | three polysaccharides including a neutral polysaccharide (rn), an acidic polysaccharide (ra) and a pectic polysaccharide (rp) were isolated from aerial part of portulaca oleracea l. and evaluated for their anti-herpes simplex virus type 2 (hsv-2) and anti-influenza a virus (ifv-a). rn was found to consist of glucose (glc), mannose (man) and arabinose (ara) with small amounts of galactose (gal), and identified to be an arabinoglucomannan. ra was mainly composed of gal and ara with a small proport ... | 2010 | 20410633 |
| seroprevalence of herpes simplex virus type 2 among persons aged 14-49 years--united states, 2005-2008. | herpes simplex virus type 2 (hsv-2) is one of the most common sexually transmitted infections worldwide and the primary cause of genital and neonatal herpes and genital ulcer disease. multiple studies have shown that hsv-2 infection increases the risk for human immunodeficiency virus (hiv) infection by at least twofold. hsv-2 infection is lifelong, and serologic testing provides the best method to estimate hsv-2 prevalence. since 1976, cdc has monitored hsv-2 seroprevalence in the united states ... | 2010 | 20414188 |
| increased risk of hiv acquisition among kenyan men with human papillomavirus infection. | few data on the effect of human papillomavirus (hpv) infection on human immunodeficiency virus (hiv) acquisition are available. | 2010 | 20415595 |
| neighbor effects of neurons bearing protective transgenes. | viral vectors bearing protective transgenes can decrease neurotoxicity after varied necrotic insults. a neuron that dies necrotically releases glutamate, calcium and reactive oxygen species, thereby potentially damaging neighboring neurons. this raises the possibility that preventing such neuron death via gene therapy can secondarily protect neighboring neurons that, themselves, do not express a protective transgene. we determined whether such "good neighbor" effects occur, by characterizing neu ... | 2010 | 20417625 |
| socio-demographic and behavioral correlates of herpes simplex virus type 1 and 2 infections and co-infections among adults in the usa. | although herpes simplex virus (hsv)-1 and hsv-2 may co-exist and interact, some epidemiologic features including geographical distribution, secular trends, route of transmission, and established risk factors may distinguish these hsv sub-types. with recent data indicating a link between genital herpes and either strain, a re-evaluation of risk factors for hsv-1/hsv-2 infection and co-infection is needed. | 2010 | 20418142 |
| etiology of dna virus infections in liver transplant recipients with neonatal hepatitis. | neonatal hepatitis is a syndrome of symptoms associated with a history that includes any type of infectious, genetic, toxic, or metabolic causation. various infectious agents have been implicated in hepatic inflammation in neonates including bacterial and viral pathogens, especially dna viruses. we used molecular and antigenic methods to evaluate the role of dna viruses, such as hepatitis type b viruses (hbv), human cytomegalovirus (hcmv), herpes simplex virus (hsv), and adenovirus, in neonatal ... | 2010 | 20430185 |
| follow the footprints to the diagnosis in a patient with meningismus. | 2010 | 20433354 | |
| immunomodulatory and antiviral activity of almond skins. | the elimination of a viral infection requires a proinflammatory host response (type 1 immunity), characterized by activation of mononuclear cells and production of proinflammatory cytokines, such as interferons (ifns), tumor necrosis factor (tnf)-alpha and interleukin (il)-12. on the other hand, il-4 and il-10 play a role in decreasing the inflammatory response supported by helper t (th)1 cells. in this study we evaluated the effects of almond skins on the release of cytokines by peripheral bloo ... | 2010 | 20438761 |
| impact of aciclovir on ulcer healing, lesional, genital and plasma hiv-1 rna among patients with genital ulcer disease in malawi. | by a randomised, double-blind, placebo-controlled trial of aciclovir 800 mg twice daily for 5 days added to the syndromic management of genital ulcer disease (gud) to determine the impact on ulcer healing and hiv outcomes. | 2010 | 20444742 |
| overwhelming disseminated herpes simplex virus type 2 infection in a patient with severe burn injury: case report and literature review. | viral-mediated organ disease is an infrequent but recognized complication of severe burn injury. this occurs primarily because of herpes family viruses such as cytomegalovirus, herpes simplex virus (hsv), and epstein-barr virus given their ability to establish lifelong latency after primary infection and reactivate in the setting of altered immune function. in this report, we describe a severely burned patient who succumbed to fulminant hsv-2 pneumonitis and hepatitis, and summarize the existing ... | 2010 | 20453737 |
| human herpes simplex viruses in benign and malignant thyroid tumours. | to test the hypothesis that herpes viruses may have a role in thyroid neoplasia, we analysed thyroid tissues from patients with benign (44) and malignant (65) lesions for hsv1 and hsv2 dna. confirmatory studies included direct sequencing, analysis of viral gene expression, and activation of viral-inducible signalling pathways. expression of viral entry receptor nectin-1 was examined in human samples and in cancer cell lines. in vitro experiments were performed to explore the molecular mechanisms ... | 2010 | 20455254 |