Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| the spread of wolbachia through mosquito populations. | in many regions of the world, mosquito-borne viruses pose a growing threat to human health. as an alternative to traditional control measures, the bacterial symbiont wolbachia has been transferred from drosophila into the mosquito aedes aegypti, where it can block the transmission of dengue and zika viruses. a recent paper has reported large-scale releases of wolbachia-infected ae. aegypti in the city of cairns, australia. wolbachia, which is maternally transmitted, invaded and spread through th ... | 2017 | 28570608 |
| effects of sublethal exposure to metofluthrin on the fitness of aedes aegypti in a domestic setting in cairns, queensland. | metofluthrin is highly effective at reducing biting activity in aedes aegypti. its efficacy lies in the rapid onset of confusion, knockdown, and subsequent kill of a mosquito. in the field, there are a variety of scenarios that might result in sublethal exposure to metofluthrin, including mosquitoes that are active at the margins of the chemical's lethal range, brief exposure as mosquitoes fly in and out of treated spaces or decreasing efficacy of the emanators with time. sublethal effects are k ... | 2017 | 28569175 |
| molecular studies with aedes (stegomyia) aegypti (linnaeus, 1762), mosquito transmitting the dengue virus. | dengue is an infectious viral disease, which can present a wide clinical picture, ranging from oligo or asymptomatic forms, to bleeding and shock, and can progress to death. the disease problem has increased in recent years, especially in urban and suburban areas of tropical and subtropical regions. there are five dengue viruses, called serotypes (den-1, den-2, den-3, den-4, and den-5), which belong to the flaviviridae family and are transmitted to humans through infected mosquito bites, with th ... | 2017 | 28560571 |
| metofluthrin: investigations into the use of a volatile spatial pyrethroid in a global spread of dengue, chikungunya and zika viruses. | metofluthrin reduces biting activity in aedes aegypti through the confusion, knockdown, and subsequent kill of a mosquito. a geographical spread in dengue, chikungunya, and zika viruses, increases intervention demands. response to a zika outbreak may require a different strategy than dengue, as high-risk individuals, specifically pregnant women, need to be targeted. | 2017 | 28558804 |
| local introduction and heterogeneous spatial spread of dengue-suppressing wolbachia through an urban population of aedes aegypti. | dengue-suppressing wolbachia strains are promising tools for arbovirus control, particularly as they have the potential to self-spread following local introductions. to test this, we followed the frequency of the transinfected wolbachia strain wmel through ae. aegypti in cairns, australia, following releases at 3 nonisolated locations within the city in early 2013. spatial spread was analysed graphically using interpolation and by fitting a statistical model describing the position and width of ... | 2017 | 28557993 |
| elevation as a proxy for mosquito-borne zika virus transmission in the americas. | when zika virus (zikv) first began its spread from brazil to other parts of the americas, national-level travel notices were issued, carrying with them significant economic consequences to affected countries. although regions of some affected countries were likely unsuitable for mosquito-borne transmission of zikv, the absence of high quality, timely surveillance data made it difficult to confidently demarcate infection risk at a sub-national level. in the absence of reliable data on zikv activi ... | 2017 | 28542540 |
| uncovering the repertoire of endogenous flaviviral elements in aedes mosquito genomes. | endogenous viral elements derived from nonretroviral rna viruses have been described in various animal genomes. whether they have a biological function, such as host immune protection against related viruses, is a field of intense study. here, we investigated the repertoire of endogenous flaviviral elements (efves) in aedes mosquitoes, the vectors of arboviruses such as dengue and chikungunya viruses. previous studies identified three efves from aedes albopictus cell lines and one from aedes aeg ... | 2017 | 28539440 |
| enhanced larvicidal, antibacterial, and photocatalytic efficacy of tio2 nanohybrids green synthesized using the aqueous leaf extract of parthenium hysterophorus. | titanium dioxide nanoparticles are emerging as a biocompatible nanomaterial with multipurpose bioactivities. in this study, titanium dioxide (tio2) nanoparticles were effectively synthesized using the aqueous leaf extracts of parthenium hysterophorus prepared by microwave irradiation. tio2 nanoparticles were fabricated by treating the p. hysterophorus leaf extracts with the tio4 solution. biologically active compounds such as alcohols, phenols, alkanes, and fluoroalkanes were involved in bioredu ... | 2017 | 28537028 |
| transovarial transmission of denv in aedes aegypti in the amazon basin: a local model of xenomonitoring. | transovarial transmission of dengue virus in aedes spp. mosquitoes is considered an important mechanism for the maintenance of the virus in nature and may be implicated in the occurrence of outbreaks and epidemics of the disease. however, there are few studies involving transovarial transmission and viral vector monitoring as a surveillance tool and control strategy. the present study evaluated transovarial transmission of dengue virus in aedes aegypti populations as a xenomonitoring strategy in ... | 2017 | 28526066 |
| zika virus: obstetric and pediatric anesthesia considerations. | as of november 2016, the florida department of health (fdh) and the centers for disease control and prevention have confirmed more than 4000 travel-related zika virus (zikv) infections in the united states with >700 of those in florida. there have been 139 cases of locally acquired infection, all occurring in miami, florida. within the us territories (eg, puerto rico, us virgin islands), >30,000 cases of zikv infection have been reported. the projected number of individuals at risk for zikv infe ... | 2017 | 28525510 |
| impact of simultaneous exposure to arboviruses on infection and transmission by aedes aegypti mosquitoes. | the recent emergence of both chikungunya and zika viruses in the americas has significantly expanded their distribution and has thus increased the possibility that individuals may become infected by more than one aedes aegypti-borne virus at a time. recent clinical data support an increase in the frequency of coinfection in human patients, raising the likelihood that mosquitoes could be exposed to multiple arboviruses during one feeding episode. the impact of coinfection on the ability of releva ... | 2017 | 28524874 |
| life-shortening wolbachia infection reduces population growth of aedes aegypti. | wolbachia bacteria are being introduced into natural populations of vector mosquitoes, with the goal of reducing the transmission of human diseases such as zika and dengue fever. the successful establishment of wolbachia infection is largely dependent on the effects of wolbachia infection to host fitness, but the effects of wolbachia infection on the individual life-history traits of immature mosquitoes can vary. here, the effects of life-shortening wolbachia (wmelpop) on population growth of in ... | 2017 | 28506794 |
| fta cards facilitate storage, shipment, and detection of arboviruses in infected aedes aegypti collected in adult mosquito traps. | abstractthe utility of applying infected aedes aegypti to flinders technology associates (fta(®)) cards for storage, transport, and detection of dengue, zika, and barmah forest viruses was assessed in laboratory-based experiments. the mosquitoes had been removed from gravid aedes traps maintained under conditions of high temperature and humidity. rna of all viruses could be detected in infected mosquitoes on fta cards either individually or in pools with uninfected mosquitoes, and stored for up ... | 2017 | 28500814 |
| interaction of flavivirus with their mosquito vectors and their impact on the human health in the americas. | some of the major arboviruses with public health importance, such as dengue, yellow fever, zika and west nile virus are mosquito-borne or mosquito-transmitted flavivirus. their principal vectors are from the family culicidae, aedes aegypti and aedes albopictus being responsible of the urban cycles of dengue, zika and yellow fever virus. these vectors are highly competent for transmission of many arboviruses. the genetic variability of the vectors, the environment and the viral diversity modulate ... | 2017 | 28499872 |
| zingiber cernuum (zingiberaceae) essential oil as effective larvicide and oviposition deterrent on six mosquito vectors, with little non-target toxicity on four aquatic mosquito predators. | mosquitoes are responsible for the transmission of many pathogens and parasites, which cause serious diseases in humans and animals. currently, botanical products have been suggested as alternative tools in the fight against arthropod vectors. in this study, the essential oil (eo) extracted from zingiber cernuum was tested as larvicide and oviposition deterrent on six mosquito species of public health relevance, including malaria and zika virus vectors. the eo showed high toxicity on third insta ... | 2017 | 28497331 |
| development of nanoemulsion from vitex negundo l. essential oil and their efficacy of antioxidant, antimicrobial and larvicidal activities (aedes aegypti l.). | it is believed that nanoemulsions were emerged as a promising candidate to improve the qualities of natural essential oil towards antimicrobial and insecticidal applications. in the present study, we have focused on the encapsulation of vitex negundo l. leaf essential oil using polysorbate80 for its different biological activities including antioxidant, bactericidal and larvicidal activity against dengue fever vector aedes aegypti l. initially, the nanoemulsion was prepared by low energy method ... | 2017 | 28497330 |
| larvicidal activity of lignans and alkaloid identified in zanthoxylum piperitum bark toward insecticide-susceptible and wild culex pipiens pallens and aedes aegypti. | the yellow fever mosquito, aedes aegypti, and the common house mosquito, culex pipiens pallens, transmit dengue fever and west nile virus diseases, respectively. this study was conducted to determine the toxicity of the three lignans (-)-asarinin, sesamin and (+)-xanthoxylol-γ,γ-dimethylallylether (xda), and the alkaloid pellitorine from zanthoxylum piperitum (rutaceae) bark to third-instar larvae from insecticide-susceptible c. pipiens pallens and ae. aegypti as well as wild c. pipiens pallens ... | 2017 | 28472971 |
| zika virus alters the microrna expression profile and elicits an rnai response in aedes aegypti mosquitoes. | zika virus (zikv), a flavivirus transmitted primarily by aedes aegypti, has recently spread globally in an unprecedented fashion, yet we have a poor understanding of host-microbe interactions in this system. to gain insights into the interplay between zikv and the mosquito, we sequenced the small rna profiles in zikv-infected and non-infected ae. aegypti mosquitoes at 2, 7 and 14 days post-infection. zika induced an rnai response in the mosquito with virus-derived short interfering rnas and piwi ... | 2017 | 28715413 |
| biopolymer zein-coated gold nanoparticles: synthesis, antibacterial potential, toxicity and histopathological effects against the zika virus vector aedes aegypti. | the control of multidrug-resistant bacteria as well as insect pests and vectors is timely and important now a days. the present study was designed to evaluate the in vitro antibacterial, antibiofilm and mosquito larvicidal effects of gold nanoparticles synthesized using the zein biopolymer (ze-aunps) against gram positive (bacillus pumilus and bacillus subtilis), gram negative (shigella sonnei and pseudomonas aeruginosa) bacteria and third instar larvae of the dengue and zika virus vector aedes ... | 2017 | 28654862 |
| cell fusing agent virus and dengue virus mutually interact in aedes aegypti cell lines. | the genus flavivirus contains more than 70 single-stranded, positive-sense arthropod-borne rna viruses. some flaviviruses are particularly medically important to humans and other vertebrates including dengue virus (denv), west nile virus, and yellow fever virus. these viruses are transmitted to vertebrates by mosquitoes and other arthropod species. mosquitoes are also infected by insect-specific flaviviruses (isfs) that do not appear to be infective to vertebrates. cell fusing agent virus (cfav) ... | 2017 | 28761113 |
| experimental infection with and maintenance of cell fusing agent virus (flavivirus) in aedes aegypti. | during the past two decades, there has been a dramatic increase in the recognition and characterization of novel insect-specific flaviviruses (isfvs). some of these agents are closely related to important mosquito-borne flavivirus pathogens. results of experimental studies suggest that mosquitoes and mosquito cell cultures infected with some isfvs are refractory to superinfection with related flavivirus pathogens; and it has been proposed that isfvs potentially could be used to alter the vector ... | 2017 | 28719335 |
| activation of aedes aegypti prophenoloxidase-3 and its role in the immune response against entomopathogenic fungi. | serine protease cascade-mediated melanization is an important innate immune response in insects and crustaceans, which involves the proteolytic activation of prophenoloxidase (ppo). in this study, we investigated the role of aedes aegypti ppo3 in antifungal immune defence. we expressed and purified recombinant ppo3 (rppo3) in escherichia coli and demonstrated that rppo3 was activated by ethanol and, to a lesser extent, by cetylpyridinium chloride. in the presence of cu(2+) , rppo3 exhibited enzy ... | 2017 | 28556276 |
| understanding the role of micrornas in the interaction of aedes aegypti mosquitoes with an insect-specific flavivirus. | the flavivirus genus contains some of the most prevalent vector-borne viruses, such as the dengue, zika and yellow fever viruses that cause devastating diseases in humans. however, the insect-specific clade of flaviviruses is restricted to mosquito hosts, albeit they have retained the general features of the genus, such as genome structure and replication. the interactions between insect-specific flaviviruses (isfs) and their mosquito hosts are largely unknown. pathogenic flaviviruses are known ... | 2017 | 28699859 |
| modelling dengue fever risk in the state of yucatan, mexico using regional-scale satellite-derived sea surface temperature. | accurately predicting vector-borne diseases, such as dengue fever, is essential for communities worldwide. changes in environmental parameters such as precipitation, air temperature, and humidity are known to influence dengue fever dynamics. furthermore, previous studies have shown how oceanographic variables, such as el niño southern oscillation (enso)-related sea surface temperature from the pacific ocean, influences dengue fever in the americas. however, literature is lacking on the use of re ... | 2017 | 28450208 |
| detecting the impact of temperature on transmission of zika, dengue, and chikungunya using mechanistic models. | recent epidemics of zika, dengue, and chikungunya have heightened the need to understand the seasonal and geographic range of transmission by aedes aegypti and ae. albopictus mosquitoes. we use mechanistic transmission models to derive predictions for how the probability and magnitude of transmission for zika, chikungunya, and dengue change with mean temperature, and we show that these predictions are well matched by human case data. across all three viruses, models and human case data both show ... | 2017 | 28448507 |
| juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the aedes aegypti mosquito. | juvenile hormone (jh) controls many biological activities in insects, including development, metamorphosis, and reproduction. in the aedes aegypti mosquito, a vector of dengue, yellow fever, chikungunya, and zika viruses, the metabolic tissue (the fat body, which is an analogue of the vertebrate liver) produces yolk proteins for developing oocytes. jh is important for the fat body to acquire competence for yolk protein production. however, the molecular mechanisms of how jh promotes mosquito rep ... | 2017 | 28446607 |
| species abundance and temporal variation of arbovirus vectors in brownsville, texas. | the recent outbreaks of the dengue fever and west nile viruses and the looming threats of the zika and chikungunya viruses highlight the importance of establishing effective, proactive arboviral surveillance in communities at high risk of transmission, such as those on the texas-mexico border. currently, there are no approved human vaccines available for these mosquito-borne diseases, so entomological control and case management are the only known methods for decreasing disease incidence. the pr ... | 2017 | 28444003 |
| dengue virus replicates and accumulates in aedes aegypti salivary glands. | dengue virus (denv) is an rna virus transmitted among humans by mosquito vectors, mainly aedes aegypti. denv transmission requires viral dissemination from the mosquito midgut to the salivary glands. during this process the virus undergoes several population bottlenecks, which are stochastic reductions in population size that restrict intra-host viral genetic diversity and limit the efficiency of natural selection. despite the implications for virus transmission and evolution, denv replication i ... | 2017 | 28431281 |
| yellow fever from angola and congo: a storm gathers. | in common with zika, chikungunya and dengue, yellow fever (yf) is an arthropod-borne flavivirus. it is transmitted between humans and from monkeys by mosquitoes of the aedes aegypti (its principal vector), haemogogus and albopictus varieties. three cycles of transmission may occur: urban; sylvatic; and intermediate. recently, sub-saharan africa has seen the resurgence of this neglected disease. the current yf outbreak in angola began in december 2015 in the capital luanda and by october 2016 the ... | 2017 | 28424031 |
| detection of a new pyrethroid resistance mutation (v410l) in the sodium channel of aedes aegypti: a potential challenge for mosquito control. | the yellow fever mosquito, aedes aegypti, particularly in neotropical regions, is the principal vector of dengue, yellow fever, zika and chikungunya viruses. pyrethroids remain one of the most used insecticides to control aedes mosquitoes, despite the development of pyrethroid resistance in many mosquito populations worldwide. here, we report a brazilian strain of a. aegypti with high levels (approximately 100-60,000 fold) of resistance to both type i and type ii pyrethroids. we detected two mut ... | 2017 | 28422157 |
| deploying dengue-suppressing wolbachia : robust models predict slow but effective spatial spread in aedes aegypti. | a novel strategy for controlling the spread of arboviral diseases such as dengue, zika and chikungunya is to transform mosquito populations with virus-suppressing wolbachia. in general, wolbachia transinfected into mosquitoes induce fitness costs through lower viability or fecundity. these maternally inherited bacteria also produce a frequency-dependent advantage for infected females by inducing cytoplasmic incompatibility (ci), which kills the embryos produced by uninfected females mated to inf ... | 2017 | 28411063 |
| severe dengue due to secondary hemophagocytic lymphohistiocytosis: a case study. | dengue, transmitted by the mosquito aedes aegypti affects millions of people worldwide every year. dengue induced hemophagocytic lymphohistiocytosis (hlh) is a serious condition and may prove fatal if not detected early and treated appropriately. diagnosis of hlh is challenging and usually missed as clinical and laboratory findings are nonspecific. moreover, the pathophysiology of the systemic inflammatory response syndrome and/or sepsis is remarkably similar to hlh. secondary hlh following infe ... | 2017 | 28409119 |
| vector competence and innate immune responses to dengue virus infection in selected laboratory and field-collected stegomyia aegypti (= aedes aegypti). | control of dengue virus (denv) transmission, primarily based on strategies to reduce populations of the principle vector stegomya aegypti (= aedes aegypti) (diptera: culicidae), is difficult to sustain over time. other potential strategies aim to manipulate characteristics such as vector competence (vc), the innate capacity of the vector to transmit the virus. previous studies have identified genetic factors, including differential expression of apoptosis-related genes, associated with the refra ... | 2017 | 28407282 |
| advances in vector control science: rear-and-release strategies show promise… but don't forget the basics. | both chikungunya and zika viruses have recently swept from africa across the pacific to the americas, causing major outbreaks of disease in humans. in the meantime, dengue epidemics continue throughout the tropics. traditional vector control programs based on strategies from 1950s and 1960s have been relatively ineffective in combating recent epidemics. in response, new methods involving the rearing and releasing of large numbers of mosquitoes to eliminate or modify local aedes populations are b ... | 2017 | 28403439 |
| aedes aegypti (diptera: culicidae) abundance model improved with relative humidity and precipitation-driven egg hatching. | we propose an improved aedes aegypti (l.) abundance model that takes into account the effect of relative humidity (rh) on adult survival, as well as rainfall-triggered egg hatching. the model uses temperature-dependent development rates described in the literature as well as documented estimates for mosquito survival in environments with high rh, and for egg desiccation. we show that combining the two additional components leads to better agreement with surveillance trap data and with dengue inc ... | 2017 | 28402546 |
| repellency of 29 synthetic and natural commercial topical insect repellents against aedes aegypti (diptera: culicidae) in central mexico. | in mexico, the use of repellents to prevent insects from landing and biting is a common practice. however, variation in the efficiency of natural and synthetic repellents has been observed. in this study, we evaluated the repellency and protection time of 16 synthetic and 13 natural-based commercial products against aedes aegypti (l.) from an endemic dengue area (jojutla, morelos) in central mexico. the "arm exposure" cage test was used to assess the efficacy of the repellents. tests were conduc ... | 2017 | 28402436 |
| why is aedes aegypti linnaeus so successful as a species? | diseases transmitted by mosquitoes impose enormous burden towards human morbidity and mortality. over the last three decades, brazil has suffered from severe dengue epidemics. in september 2014, this situation is further complicated by the introduction of two other viruses, zika and chikungunya, placing brazil in a triple epidemic. in this article, we discuss the biology of aedes aegypti linnaeus, and the principal initiatives currently used to control mosquito populations and the diseases they ... | 2017 | 28401481 |
| synergistic efficacy of aedes aegypti antimicrobial peptide cecropin a2 and tetracycline against pseudomonas aeruginosa. | the increasing prevalence of antibiotic resistance has created an urgent need for alternative drugs with new mechanisms of action. antimicrobial peptides (amps) are promising candidates that could address the spread of multidrug-resistant bacteria, either alone or in combination with conventional antibiotics. we studied the antimicrobial efficacy and bactericidal mechanism of cecropin a2, a 36-residue α-helical cationic peptide derived from aedes aegypti cecropin a, focusing on the common pathog ... | 2017 | 28483966 |
| aedes aegypti piwi4 is a noncanonical piwi protein involved in antiviral responses. | the small interfering rna (sirna) pathway is a major antiviral response in mosquitoes; however, another rna interference pathway, the piwi-interacting rna (pirna) pathway, has been suggested to be antiviral in mosquitoes. piwi4 has been reported to be a key mediator of this response in mosquitoes, but it is not involved in the production of virus-specific pirnas. here, we show that piwi4 associates with members of the antiviral exogenous sirna pathway (ago2 and dcr2), as well as with proteins of ... | 2017 | 28497119 |
| characterization of tolypocladium cylindrosporum (hypocreales: ophiocordycipitaceae) and its impact against aedes aegypti and aedes albopictus eggs at low temperature. | we examined the growth characteristics of tolypocladium cylindrosporum ibt 41712 and its potential to infect eggs of aedes aegypti and ae. albopictus at a low temperature (15°c). when grown on sabouraud dextrose agar supplemented with yeast extract, the ibt 41712 formed white colonies turning to a slightly darker, off-white color when mature. the mycelia bore swollen conidiophores producing smooth-walled, oblong to cylindrical conidia with varying sizes, ranging from 1.5 to 3.5 μm long. to deter ... | 2017 | 28854112 |
| the role of the environment in the evolution of tolerance and resistance to a pathogen. | defense against parasites can be divided into resistance, which limits parasite burden, and tolerance, which reduces pathogenesis at a given parasite burden. distinguishing between the two and understanding which defense is favored by evolution in different ecological settings are important, as they lead to fundamentally different evolutionary trajectories of host-parasite interactions. we let the mosquito aedes aegypti evolve under different food levels and with either no parasite, a constant p ... | 2017 | 28829641 |
| specificity and putative mode of action of a mosquito larvicidal toxin from the bacterium xenorhabdus innexi. | reduction of mosquito-borne diseases relies, in part, on the use of synthetic pesticides to control pest mosquitoes. this reliance has led to genetic resistance, environmental contamination and the nondiscriminatory elimination of both pest and non-pest species. to expand our options for control, we screened entomopathogenic bacteria for potential larvicidal activity. a lipopeptide from the bacterium, xenorhabdus innexi, was discovered that displayed potent larvicidal activity. the lc50s of the ... | 2017 | 28712711 |
| potential risk of re-emergence of urban transmission of yellow fever virus in brazil facilitated by competent aedes populations. | yellow fever virus (yfv) causing a deadly viral disease is transmitted by the bite of infected mosquitoes. in brazil, yfv is restricted to a forest cycle maintained between non-human primates and forest-canopy mosquitoes, where humans can be tangentially infected. since late 2016, a growing number of human cases have been reported in southeastern brazil at the gates of the most populated areas of south america, the atlantic coast, with rio de janeiro state hosting nearly 16 million people. we sh ... | 2017 | 28687779 |
| taking innovative vector control interventions in urban latin america to scale: lessons learnt from multi-country implementation research. | prior to the current public health emergency following the emergence of chikungunya and zika virus disease in the americas during 2014 and 2015, multi-country research investigated between 2011 and 2013 the efficacy of novel aedes aegypti intervention packages through cluster randomised controlled trials in four latin-american cities: fortaleza (brazil); girardot (colombia), acapulco (mexico) and salto (uruguay). results from the trials led to a scaling up effort of the interventions at city lev ... | 2017 | 28829235 |
| modeling the transmission and control of zika in brazil. | zika virus, a reemerging mosquito-borne flavivirus, started spread across central and southern america and more recently to north america. the most serious impacted country is brazil. based on the transmission mechanism of the virus and assessment of the limited data on the reported suspected cases, we establish a dynamical model which allows us to estimate the basic reproduction number r 0 = 2.5020. the wild spreading of the virus make it a great challenge to public health to control and preven ... | 2017 | 28798323 |
| differential outcomes of zika virus infection in aedes aegypti orally challenged with infectious blood meals and infectious protein meals. | infection of mosquitoes is an essential step for the transmission of mosquito-borne arboviruses in nature. engorgement of infectious blood meals from viremic infected vertebrate hosts allows the entry of viruses and initiates infection of midgut epithelial cells. historically, the infection process of arboviruses in mosquitoes has been studied through the engorgement of mosquitoes from viremic laboratory animals or from artificial feeders containing blood mixed with viruses harvested from cell c ... | 2017 | 28796799 |
| zika virus replication in the mosquito culex quinquefasciatus in brazil. | zika virus (zikv) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. the virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. the aedes aegypti mosquito is considered to be the main vector to humans worldwide; however, there is evidence that other mosquito species, including culex quinquefasciatus, transmit the virus. to test the potential of cx ... | 2017 | 28790458 |
| sexual and vertical transmission of zika virus in anti-interferon receptor-treated rag1-deficient mice. | although zika virus (zikv) is primarily transmitted to humans by the aedes aegypti mosquito, human-to-human transmission has also been observed from males-to-females as well as mother-to-offspring. in the current study, we studied both sexual transmission (stx) and vertical transmission (vtx) of zikv using anti-ifnar1-treatment of rag1 (-/-) (air) mice. these mice have suppressed type i ifn responses and lack adaptive immune responses, leading to a prolonged infection prior to clinical disease. ... | 2017 | 28775298 |
| culex quinquefasciatus from areas with the highest incidence of microcephaly associated with zika virus infections in the northeast region of brazil are refractory to the virus. | zika virus (zikv) is widely distributed in brazil and the northeast region (ne) is the most affected zone, showing the highest incidence of microcephaly associated with zikv congenital infections worldwide. we report attempts to infect three populations of culex quinquefasciatus from severely affected sites in the ne and southeast region (se) of brazil with three strains of zikv isolated from these localities. an aedes aegypti population from the se was used as a positive control. all tested cx. ... | 2017 | 28767975 |
| linking only aedes aegypti with zika virus has world-wide public health implications. | 2017 | 28736548 | |
| zika virus transmission to mouse ear by mosquito bite: a laboratory model that replicates the natural transmission process. | zika disease has transformed into a serious global health problem due to the rapid spread of the arbovirus and alarming severity including congenital complications, microcephaly and guillain-barré syndrome. zika virus (zikv) is primarily transmitted to humans through the bite of an infective mosquito, with aedes aegypti being the main vector. | 2017 | 28728607 |
| asymptomatic transmission and the dynamics of zika infection. | following the 2013-14 outbreak in french polynesia, the zika virus (zikv) epidemic spread widely to many countries where aedes aegypti as the main transmitting vector is endemic. the lack of a second wave of zikv infection in most affected regions may suggest that a sufficiently high level of herd immunity was reached during the first wave. we developed an agent-based transmission model to investigate the role of asymptomatic infection on the likelihood of observing a second wave, while accounti ... | 2017 | 28724972 |
| american aedes vexans mosquitoes are competent vectors of zika virus. | abstractstarting in 2013-2014, the americas have experienced a massive outbreak of zika virus (zikv) which has now reached at least 49 countries. although most cases have occurred in south america and the caribbean, imported and autochthonous cases have occurred in the united states. aedes aegypti and aedes albopictus mosquitoes are known vectors of zikv. little is known about the potential for temperate aedes mosquitoes to transmit zikv. aedes vexans has a worldwide distribution, is highly abun ... | 2017 | 28719283 |
| early evidence for zika virus circulation among aedes aegypti mosquitoes, rio de janeiro, brazil. | during 2014-2016, we conducted mosquito-based zika virus surveillance in rio de janeiro, brazil. results suggest that zika virus was probably introduced into the area during may-november 2013 via multiple in-country sources. furthermore, our results strengthen the hypothesis that zika virus in the americas originated in brazil during october 2012-may 2013. | 2017 | 28628464 |
| a single substitution changes zika virus infectivity in mosquitoes. | zika virus (zikv) has caused outbreaks in the pacific and the americas. the mechanism underlying the recent zikv epidemic remains obscure. a recent study reveals that an amino acid substitution is associated with increased infectivity of zikv in the aedes aegypti mosquito. | 2017 | 28610876 |
| zika vector transmission risk in temperate australia: a vector competence study. | zika virus is an emerging pathogen of global importance. it has been responsible for recent outbreaks in the americas and in the pacific region. this study assessed five different mosquito species from the temperate climatic zone in australia and included aedes albopictus as a potentially invasive species. | 2017 | 28599659 |
| emerging infectious disease agents and blood safety in australia: spotlight on zika virus. | emerging infectious diseases (eids) are infectious diseases whose incidence has increased in humans in the past 20 years or could increase in the near future. eid agents may represent a threat to blood safety if they infect humans, cause a clinically significant illness, include an asymptomatic blood phase in the course of infection, and are transmissible by transfusion. eid agents are typically not well characterised, but there is a consensus that we can expect ongoing outbreaks. strategies to ... | 2017 | 28566073 |
| genomic epidemiology reveals multiple introductions of zika virus into the united states. | zika virus (zikv) is causing an unprecedented epidemic linked to severe congenital abnormalities. in july 2016, mosquito-borne zikv transmission was reported in the continental united states; since then, hundreds of locally acquired infections have been reported in florida. to gain insights into the timing, source, and likely route(s) of zikv introduction, we tracked the virus from its first detection in florida by sequencing zikv genomes from infected patients and aedes aegypti mosquitoes. we s ... | 2017 | 28538723 |
| de novo generation and characterization of new zika virus isolate using sequence data from a microcephaly case. | zika virus (zikv) has recently emerged and is the etiological agent of congenital zika syndrome (czs), a spectrum of congenital abnormalities arising from neural tissue infections in utero. herein, we describe the de novo generation of a new zikv isolate, zikvnatal, using a modified circular polymerase extension reaction protocol and sequence data obtained from a zikv-infected fetus with microcephaly. zikvnatal thus has no laboratory passage history and is unequivocally associated with czs. zikv ... | 2017 | 28529976 |
| outbreak of zika virus infection in singapore: an epidemiological, entomological, virological, and clinical analysis. | an outbreak of zika virus infection was detected in singapore in august, 2016. we report the first comprehensive analysis of a national response to an outbreak of zika virus infection in asia. | 2017 | 28527892 |
| eco-friendly and cost-effective ag nanocrystals fabricated using the leaf extract of habenaria plantaginea: toxicity on six mosquito vectors and four non-target species. | recently, the biofabrication of metal nanoparticles has gained wide interest owing to its inherent features such as swift, simplicity, eco-friendliness, and cheaper costs. different green-reducing agents led to the production of nanoparticles with varying toxicity on insects. in the current study, silver nanoparticles (agnps) were successfully synthesized using habenaria plantaginea leaf extract. ag nanoparticles were studied by uv-vis spectroscopy (uv-vis), x-ray diffraction (xrd), fourier tran ... | 2017 | 28523613 |
| evolutionary enhancement of zika virus infectivity in aedes aegypti mosquitoes. | zika virus (zikv) remained obscure until the recent explosive outbreaks in french polynesia (2013-2014) and south america (2015-2016). phylogenetic studies have shown that zikv has evolved into african and asian lineages. the asian lineage of zikv was responsible for the recent epidemics in the americas. however, the underlying mechanisms through which zikv rapidly and explosively spread from asia to the americas are unclear. non-structural protein 1 (ns1) facilitates flavivirus acquisition by m ... | 2017 | 28514450 |
| a location-specific spreadsheet for estimating zika risk and timing for zika vector surveillance, using us military facilities as an example. | local zika virus transmission in the united states involving one or both of the known vector species, aedes aegypti and ae. albopictus, is of major concern. to assist efforts to anticipate the risks of transmission, we developed an excel spreadsheet tool that uses vector and virus temperature thresholds, remotely sensed maximum temperature, and habitat suitability models to answer the questions: "is zika transmission likely here?" and "when should we conduct vector surveillance?" an example spre ... | 2017 | 28511272 |
| transmission incompetence of culex quinquefasciatus and culex pipiens pipiens from north america for zika virus. | abstractin late 2014, zika virus (zikv; flaviviridae, flavivirus) emerged as a significant arboviral disease threat in the western hemisphere. aedes aegypti and aedes albopictus have been considered the principal vectors of zikv in the new world due to viral isolation frequency and vector competence assessments. limited reports of culex transmission potential have highlighted the need for additional vector competence assessments of north american culex species. accordingly, north american culex ... | 2017 | 28500817 |
| potential of a northern population of aedes vexans (diptera: culicidae) to transmit zika virus. | zika virus is an emerging arbovirus of humans in the western hemisphere. with its potential spread into new geographical areas, it is important to define the vector competence of native mosquito species. we tested the vector competency of aedes vexans (meigen) from the lake agassiz plain of northwestern minnesota and northeastern north dakota. aedes aegypti (l.) was used as a positive control for comparison. mosquitoes were fed blood containing zika virus and 2 wk later were tested for viral inf ... | 2017 | 28499036 |
| a zika virus from america is more efficiently transmitted than an asian virus by aedes aegypti mosquitoes from asia. | zika is a mosquito-borne disease associated with neurological disorders that causes an on-going pandemic. the first outbreak was recorded in micronesia in 2007, then in french polynesia in 2014 from which it spread to south america in 2015 and ignited a widespread epidemic. interestingly, zika outbreaks in asia remained of moderate intensity although the virus is circulating. to understand these epidemiological variations, we investigated the entomological determinants of zikv transmission in as ... | 2017 | 28450714 |
| vector competence and transovarial transmission of two aedes aegypti strains to zika virus. | zika virus (zikv) has become a serious threat to global health since the outbreak in brazil in 2015. additional chinese cases have continuously been reported since the first case of laboratory-confirmed zikv infection in china on 6 february 2016. aedes aegypti is the most important vector for zikv. this study shows that two strains from china exhibit high levels of midgut infection and highly disseminated infection of salivary glands and ovaries. both strains can transmit zikv to infant mice bit ... | 2017 | 28442754 |
| effects of zika virus strain and aedes mosquito species on vector competence. | in the western hemisphere, zika virus is thought to be transmitted primarily by aedes aegypti mosquitoes. to determine the extent to which ae. albopictus mosquitoes from the united states are capable of transmitting zika virus and the influence of virus dose, virus strain, and mosquito species on vector competence, we evaluated multiple doses of representative zika virus strains in ae. aegypti and ae. albopictus mosquitoes. virus preparation (fresh vs. frozen) significantly affected virus infect ... | 2017 | 28430564 |
| competence of aedes aegypti, ae. albopictus, and culex quinquefasciatus mosquitoes as zika virus vectors, china. | in china, the prevention and control of zika virus disease has been a public health threat since the first imported case was reported in february 2016. to determine the vector competence of potential vector mosquito species, we experimentally infected aedes aegypti, ae. albopictus, and culex quinquefasciatus mosquitoes and determined infection rates, dissemination rates, and transmission rates. we found the highest vector competence for the imported zika virus in ae. aegypti mosquitoes, some sus ... | 2017 | 28430562 |
| evidence of zika virus rna fragments in aedes albopictus (diptera: culicidae) field-collected eggs from camaçari, bahia, brazil. | a major mosquito-borne viral disease outbreak caused by zika virus (zikv) occurred in bahia, brazil, in 2015, largely due to transmission by the mosquito, aedes aegypti (l.). detecting zikv in field samples of ae. aegypti has proven problematic in some locations, suggesting other mosquito species might be contributing to the spread of zikv. in this study, several (five) adult aedes albopictus (skuse) mosquitoes that emerged from a 2015 field collection of eggs from camaçari, bahia, brazil, were ... | 2017 | 28419254 |
| chemosensory responses to the repellent nepeta essential oil and its major component nepetalactone by aedes aegypti (diptera: culicidae), a vector of zika virus. | nepeta essential oil (neo; catnip) and its major component, nepetalactone, have long been known to repel insects including mosquitoes. however, the neural mechanisms through which these repellents are detected by mosquitoes, including the yellow fever mosquito aedes aegypti (l.), an important vector of zika virus, were poorly understood. here we show that neo volatiles activate olfactory receptor neurons within the basiconic sensilla on the maxillary palps of female ae. aegypti. a gustatory rece ... | 2017 | 28407077 |
| quantitative proteomic analysis of mosquito c6/36 cells reveals host proteins involved in zika virus infection. | zika virus (zikv) is an emerging arbovirus belonging to the genus flavivirus of the family flaviviridae during replication processes, flavivirus manipulates host cell systems to facilitate its replication, while the host cells activate antiviral responses. identification of host proteins involved in the flavivirus replication process may lead to the discovery of antiviral targets. the mosquitoes aedes aegypti and aedes albopictus are epidemiologically important vectors for zikv, and effective re ... | 2017 | 28404849 |
| a large scale biorational approach using bacillus thuringiensis israeliensis (strain am65-52) for managing aedes aegypti populations to prevent dengue, chikungunya and zika transmission. | aedes aegypti is a container-inhabiting mosquito and a vector of dengue, chikungunya, and zika viruses. in 2009 several cases of autochthonous dengue transmission were reported in key west, florida, usa prompting a comprehensive response to control a. aegypti. in key west, larvae of this mosquito develop in containers around human habitations which can be numerous and labor intensive to find and treat. aerial applications of larvicide covering large areas in a short time can be an efficient and ... | 2017 | 28199323 |
| levels of insecticide resistance to deltamethrin, malathion, and temephos, and associated mechanisms in aedes aegypti mosquitoes from the guadeloupe and saint martin islands (french west indies). | in the guadeloupe and saint martin islands, aedes aegypti mosquitoes are the only recognized vectors of dengue, chikungunya, and zika viruses. for around 40 years, malathion was used as a mosquito adulticide and temephos as a larvicide. since the european union banned the use of these two insecticide molecules in the first decade of the 21st century, deltamethrin and bacillus thuringiensis var. israelensis are the remaining adulticide and larvicide, respectively, used in guadeloupe. in order to ... | 2017 | 28187780 |
| response of three cyprinid fish species to the scavenger deterrent factor produced by the mutualistic bacteria associated with entomopathogenic nematodes. | the symbiotic bacteria, photorhabdus and xenorhabdus associated with entomopathogenic nematodes (epns) in the genera heterorhabditis and steinernema, respectively, produce a compound(s) called the scavenging deterrent factor (sdf). sdf deters a number of terrestrial insect scavengers and predators and one bird species from feeding on host insects killed by the nematode-bacterium complex but has not been tested against aquatic vertebrates. moreover, the heterorhabditis-photorhabdus association is ... | 2017 | 27908637 |
| entomological investigations during early stages of a chikungunya outbreak in the united states virgin islands, 2014. | during the 2014 chikungunya (chik) outbreak in the caribbean, we performed entomological surveys on 3 united states virgin islands (usvi): st. croix, st. thomas, and st. john. we aimed to evaluate the potential for chikungunya virus (chikv) transmission in the usvi. the surveys took place between june 19, 2014, and june 29, 2014, during the dry season in usvi. a total of 1,929 adult mosquitoes belonging to 4 species- culex quinquefasciatus (68.4%), aedes aegypti (29.7%), ae. mediovittatus (1.3%) ... | 2017 | 28388320 |
| potential of aedes aegypti and aedes albopictus populations in the central african republic to transmit enzootic chikungunya virus strains. | major chikungunya outbreaks have affected several central african countries during the past decade. the chikungunya virus (chikv) was isolated from humans and sylvan mosquitoes in the central african republic (car) during the 1970 and 1980s but has not been found recently, despite the presence of aedes albopictus since 2010. the risk of a massive chikungunya epidemic is therefore potentially high, as the human populations are immunologically naïve and because of the presence of the mosquito vect ... | 2017 | 28347325 |
| computer-aided structure based drug design approaches for the discovery of new anti-chikv agents. | chikungunya is a viral infection caused by chikungunya virus (chikv), an arbovirus transmitted through mosquito (aedes aegypti and aedes albopictus) bite. the virus from sylvatic cycle in africa mutated to new vector adaptation and became one of the major emerging and re-emerging viral infections in the past decade, affecting more than 40 countries. efforts are being made by many researches to develop means to prevent and control the infection through vaccines and vector control strategy. on the ... | 2017 | 28294048 |
| chikungunya infection: a global public health menace. | chikungunya virus (chikv) has been involved in epidemics in african and asian subcontinents and, of late, has transcended to affect the americas. aedes aegypti and aedes albopictus are the major vectors for chikv infection, which results in dissemination of virus to various vital organs. entry of virus into these tissues causes infiltration of innate immune cells, monocytes, macrophages, neutrophils, natural killer cells, and adaptive immune cells. macrophages bearing the replicating virus, in t ... | 2017 | 28233156 |
| aedes-borne virus-mosquito interactions: mass spectrometry strategies and findings. | aedes-borne viruses are responsible for high-impact neglected tropical diseases and unpredictable outbreaks such as the ongoing zika epidemics. aedes mosquitoes spread different arboviruses such as dengue virus (denv), chikungunya virus (chikv), and zika virus, among others, and are responsible for the continuous emergence and reemergence of these pathogens. these viruses have complex transmission cycles that include two hosts, namely the aedes mosquito as a vector and susceptible vertebrate hos ... | 2017 | 28192064 |
| environmental and social change drive the explosive emergence of zika virus in the americas. | since zika virus (zikv) was detected in brazil in 2015, it has spread explosively across the americas and has been linked to increased incidence of microcephaly and guillain-barré syndrome (gbs). in one year, it has infected over 500,000 people (suspected and confirmed cases) in 40 countries and territories in the americas. along with recent epidemics of dengue (denv) and chikungunya virus (chikv), which are also transmitted by aedes aegypti and ae. albopictus mosquitoes, the emergence of zikv s ... | 2017 | 28182667 |
| severe chikungunya infection in northern mozambique: a case report. | although chikungunya virus has rapidly expanded to several countries in sub-saharan africa, little attention has been paid to its control and management. until recently, chikungunya has been regarded as a benign and self-limiting disease. in this report we describe the first case of severe chikungunya disease in an adult patient in pemba, mozambique. | 2017 | 28179029 |
| transcriptome analysis of aedes aegypti in response to mono-infections and co-infections of dengue virus-2 and chikungunya virus. | chikungunya virus (chikv) and dengue virus (denv) spread via the bite of infected aedes mosquitoes. both these viruses exist as co-infections in the host as well as the vector and are known to exploit their cellular machinery for their replication. while there are studies reporting the changes in aedes transcriptome when infected with denv and chikv individually, the effect both these viruses have on the mosquitoes when present as co-infections is not clearly understood. in the present study, we ... | 2017 | 28161634 |
| chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen. | re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public health concern. in the past 15 years, after decades of infrequent, sporadic outbreaks, the virus has caused major epidemic outbreaks in africa, asia, the indian ocean, and more recently the caribbean and the americas. chikungunya virus is mainly transmitted by aedes aegypti mosquitoes in tropical and subtropical regions, but the potential exists for further spread because of genetic adaptation of the virus t ... | 2017 | 28159534 |
| engineered aedes aegypti jak/stat pathway-mediated immunity to dengue virus. | we have developed genetically modified ae. aegypti mosquitoes that activate the conserved antiviral jak/stat pathway in the fat body tissue, by overexpressing either the receptor dome or the janus kinase hop by the blood feeding-induced vitellogenin (vg) promoter. transgene expression inhibits infection with several dengue virus (denv) serotypes in the midgut as well as systemically and in the salivary glands. the impact of the transgenes dome and hop on mosquito longevity was minimal, but it re ... | 2017 | 28081143 |
| identification and initial characterization of matrix metalloproteinases in the yellow fever mosquito, aedes aegypti. | aedes aegypti is a major vector for arboviruses such as dengue, chikungunya and zika viruses. during acquisition of a viremic bloodmeal, an arbovirus infects mosquito midgut cells before disseminating to secondary tissues, including the salivary glands. once virus is released into the salivary ducts it can be transmitted to another vertebrate host. the midgut is surrounded by a basal lamina (bl) in the extracellular matrix, consisting of a proteinaceous mesh composed of collagen iv and laminin. ... | 2017 | 28054419 |
| [chikungunya, an emerging viral disease. proposal of an algorithm for its clinical management]. | chikungunya fever (chik) is an emerging viral disease. it is caused by the chikungunya virus, an alphavirus from the togaviridae family. it is transmitted to humans by the bite of infected mosquitoes, mainly aedes aegypti and aedes albopictus. they are also involved in the transmission of dengue, malaria, etc. chik is now endemic in any region of africa and southeast-asia. cases of chik have been reported in america, the caribbean, and europe (france, italy and spain). there are reservoirs of th ... | 2017 | 25440971 |
| [technical guidelines for the prevention and treatment of chikungunya fever]. | chikungunya fever is an emerging disease caused by an alphavirus belonging to the togaviridae family, transmitted by the bite of aedes genus species: aedesaegypti and aedesalbopictus. in 2013, paho/who received confirmation of the first cases of indigenous transmission of chikungunya in the americas. this disease may be acute, subacute and chronic, affecting all age groups. following an incubation period from three to seven days, the patient usually begins with a high fever (greater than 39 °c), ... | 2017 | 25680650 |
| optimal control problems of mosquito-borne disease subject to changes in feeding behavior of aedes mosquitoes. | dengue viruses (denv) are transmitted to humans by the bite of aedes mosquitoes. it is known that dengue virus infection in aedes aegypti female mosquitoes makes a change in the feeding behavior of the infected mosquitoes. in this study, using the forces of infection, we incorporated the effect of changes in the feeding behavior of mosquitoes into the standard vector-borne sir-si model. it has been proved that both a single-strain model and a two-strain model exhibit forward bifurcations. moreov ... | 2017 | 28385591 |
| catalase protects aedes aegypti from oxidative stress and increases midgut infection prevalence of dengue but not zika. | digestion of blood in the midgut of aedes aegypti results in the release of pro-oxidant molecules that can be toxic to the mosquito. we hypothesized that after a blood meal, the antioxidant capacity of the midgut is increased to protect cells against oxidative stress. concomitantly, pathogens present in the blood ingested by mosquitoes, such as the arboviruses dengue and zika, also have to overcome the same oxidative challenge, and the antioxidant program induced by the insect is likely to influ ... | 2017 | 28379952 |
| the relationship between entomological indicators of aedes aegypti abundance and dengue virus infection. | routine entomological monitoring data are used to quantify the abundance of ae. aegypti. the public health utility of these indicators is based on the assumption that greater mosquito abundance increases the risk of human denv transmission, and therefore reducing exposure to the vector decreases incidence of infection. entomological survey data from two longitudinal cohort studies in iquitos, peru, linked with 8,153 paired serological samples taken approximately six months apart were analyzed. i ... | 2017 | 28333938 |
| a new paradigm for aedes spp. surveillance using gravid ovipositing sticky trap and ns1 antigen test kit. | dengue remains a serious public health problem in southeast asia and has increased 37-fold in malaysia compared to decades ago. new strategies are urgently needed for early detection and control of dengue epidemics. | 2017 | 28327173 |
| biologic evidence required for zika disease enhancement by dengue antibodies. | the sudden appearance of overt human zika virus infections that cross the placenta to damage fetal tissues, target sexual organs, and are followed in some instances by guillain-barré syndrome raises questions regarding whether these outcomes are caused by genetic mutations or if prior infection by other flaviviruses affects disease outcome. because dengue and zika viruses co-circulate in the urban aedes aegypti mosquito-human cycle, a logical question, as suggested by in vitro data, is whether d ... | 2017 | 28322690 |
| occurrence of concurrent infections with multiple serotypes of dengue viruses during 2013-2015 in northern kerala, india. | dengue is a global human public health threat, causing severe morbidity and mortality. the occurrence of sequential infection by more than one serotype of dengue virus (denv) is a major contributing factor for the induction of dengue hemorrhagic fever (dhf) and dengue shock syndrome (dss), two major medical conditions caused by denv infection. however, there is no specific drug or vaccine available against dengue infection. there are reports indicating the increased incidence of concurrent infec ... | 2017 | 28316881 |
| dengue virus ns2b/ns3 protease inhibitors exploiting the prime side. | the mosquito-transmitted dengue virus (denv) infects millions of people in tropical and sub-tropical regions. maturation of denv particles requires proper cleavage of the viral polyprotein, including processing 8 of the 13 substrate cleavage sites by dengue ns2b-s3 protease. with no available direct-acting antiviral targeting denv, ns2-s3 protease is a promising target for inhibitor design. current design efforts focus on the nonprime side of the denv protease active site, resulting in highly hy ... | 2017 | 28298600 |
| the microbiome composition of aedes aegypti is not critical for wolbachia-mediated inhibition of dengue virus. | dengue virus (denv) is primarily vectored by the mosquito aedes aegypti, and is estimated to cause 390 million human infections annually. a novel method for denv control involves stable transinfection of ae. aegypti with the common insect endosymbiont wolbachia, which mediates an antiviral effect. however, the mechanism by which wolbachia reduces the susceptibility of ae. aegypti to denv is not fully understood. in this study we assessed the potential of resident microbiota, which can play impor ... | 2017 | 28267749 |
| the rnai pathway plays a small part in wolbachia-mediated blocking of dengue virus in mosquito cells. | wolbachia pipientis is an insect endosymbiont known to limit the replication of viruses including dengue and zika in their primary mosquito vector, aedes aegypti. wolbachia is being released into mosquito populations globally in a bid to control the diseases caused by these viruses. it is theorized that wolbachia's priming of the insect immune system may confer protection against subsequent viral infection. other hypotheses posit a role for competition between wolbachia and viruses for host cell ... | 2017 | 28262718 |
| population genomics reveals that an anthropophilic population of aedes aegypti mosquitoes in west africa recently gave rise to american and asian populations of this major disease vector. | the mosquito aedes aegypti is the main vector of dengue, zika, chikungunya and yellow fever viruses. this major disease vector is thought to have arisen when the african subspecies ae. aegypti formosus evolved from being zoophilic and living in forest habitats into a form that specialises on humans and resides near human population centres. the resulting domestic subspecies, ae. aegypti aegypti, is found throughout the tropics and largely blood-feeds on humans. | 2017 | 28241828 |
| zika virus and neuroscience: the need for a translational collaboration. | zika virus (zikv) has become a major challenge for scientists and health agencies. zikv's involvement with human fetal microcephaly and guillain-barré syndrome and its transmission through aedes africanus and aedes aegypti mosquitos highlighted the epidemiological and neurological risks associated to zikv infection. in 2013, zikv arrives in brazil but the first outbreak in the country was reported in 2015. here, we used the web of science as a search tool for comparing the evolution of world and ... | 2017 | 28185126 |
| a heparin-functionalized carbon nanotube-based affinity biosensor for dengue virus. | dengue virus is an arthropod-borne virus transmitted primarily by aedes mosquitos and is major cause of disease in tropical and subtropical regions. colloquially known as dengue fever, infection can cause hemorrhagic disorders and death in humans and non-human primates. we report a novel electronic biosensor based on a single-walled carbon nanotube network chemiresistive transducer that is functionalized with heparin for low-cost, label-free, ultra-sensitive, and rapid detection of whole dengue ... | 2017 | 28152487 |