Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| wuchereria bancrofti induced pancreatitis. | a case of pancreatitis of filarial origin is reported for the first time. the patient presented with chronic pancreatic pain. laparotomy revealed an inflammed pancreas and fine needle aspiration cytology confirmed pancreatitis. imprint of a peripancreatic lymphnode revealed a microfilaria. he was successfully treated with diethyl carbamazine. | 1992 | 1488798 |
| retinal involvement in wucheria bancrofti filariasis. | we report the first case of inflammation of the retinal pigment epithelium and retinal vasculities presumably caused by microfilaria of wucheria bancrofti and discuss its possible pathogenesis. therapy with diethyl carbamazine citrate resulted in rapid resolution of the inflammation. | 1992 | 1488896 |
| critical analysis of an epidemetrons model for the assessment of bancroftian filariasis endemicity in some areas in egypt. | this study attempted a trial fit of observed epidemiological data in egypt using the sasa-who-southgate epidemetrons model to quantify the endemicity and risk of transmission of filariasis. the geometric and arithmetic means (gm, am) were tried in addition to the recommended four epidemetrons of the model, prevalence rate (pr); median microfilaria density (mfd50); and linear regression coefficients (a and b). data were based on microfilaria counts in 20 mm3 finger-prick night blood samples from ... | 1992 | 1495122 |
| melanization response of two mosquito species against wuchereria bancrofti. | the melanization response of two mosquito against wuchereria bancrofti was studied under different conditions of temperatures, adult age and feeding regimes. the two mosquito species were culex pipiens, a susceptible species for w. bancrofti transmission and aedes caspius, a refractory one. | 1992 | 1500787 |
| iga immunoassay for the diagnosis of bancroftian filariasis. | in some parasitic infection such as toxoplasmosis, specific iga is a highly reliable marker of active infection. in bancroftian filariasis, only 10 of 20 (50%) and 3 of 20 (15%) of the microfilaremic patients were positive for iga anti-brugia malayi using respectively indirect elisa and immunocapture elisa tests. as regard to these low sensitivities, the detection of specific iga is unlikely to be a useful test for the diagnosis of active wuchereria bancrofti infection. | 1992 | 1519028 |
| compared efficacy of repeated annual and semi-annual doses of ivermectin and diethylcarbamazine for prevention of wuchereria bancrofti filariasis in french polynesia. final evaluation. | in october 1989, 58 apparently healthy polynesian wuchereria bancrofti carriers, in whom microfilarial (mf) density was greater than or equal to 100 mf/ml, were randomly allocated to treatment groups receiving single doses of either ivermectin at 100 mcg/kg or diethylcarbamazine (dec) at 3 and 6 mg/kg. six months later, half of the carriers initially treated with ivermectin 100 mcg/kg or dec 3 mg/kg were given a second similar dose while the rest were given a placebo. six months later again, all ... | 1992 | 1519031 |
| in vitro and in vivo effect of diethylcarbamazine on the activity of acetylcholinesterase from wuchereria bancrofti infected human serum. | the acetylcholinesterase (ache) activity was measured in human serum from persons infected with the filarial parasite wuchereria bancrofti. the asymptomatic microfilaremic serum showed five times increase in ache-activity as compared with normal serum, whereas only little difference was observed in serum from patients with elephantiasis. similar results were obtained when the enzyme activity was measured in the immune complexes precipitated with polyethyleneglycol. further, the effect of the ant ... | 1992 | 1519032 |
| bancroftian lymphangitis in northeastern brazil: a histopathological study of 17 cases. | the histological features in 17 patients (3 males and 14 females) with bancroftian lymphangitis, apparently not associated with lymphadenitis, are described. degenerative alteration in the worms and a severe inflammatory process were observed in the great majority of the cases. the patterns of tissue reaction varied, including exudative, infiltrative and granulomatous lesions. eosinophils were present, usually in great numbers. thirteen out of 14 female subjects showed involvement of the breast ... | 1992 | 1560478 |
| mass treatment of filariasis using dec-medicated salt. | diethylcarbamazine (dec)-medicated salt was used to control bancroftian filariasis in 20 endemic counties and cities of fujian province in china. the population was 5,189,126 and the microfilaria (mf) rates were between 1.56 and 11.81%. the total dose of dec was 6-10.5 g per person over a period of 2-4 months. six to 9 months after treatment the mf rate was reduced to 0-0.57% with a mean of 0.07% (621/823,796). in 184 villages sampled one year post treatment the mf rate was 0.22% (371/171,067) a ... | 1992 | 1560482 |
| control of allergic reactivity in human filariasis. predominant localization of blocking antibody to the igg4 subclass. | patients with chronic helminth infections, despite having abundant basophils and mast cells specifically sensitized with antiparasite ige and often exposed repeatedly to parasite ag, rarely manifest allergic symptoms. this control of clinical allergic reactivity likely results from ag-specific igg "blocking antibodies" shown previously to be abundant in the sera of such patients. in the present study we used two approaches to determine in which of the four igg subclasses this blocking activity w ... | 1992 | 1573266 |
| evaluation of two different antigens in immunodiagnosis of bancroftian filariasis using elisa and ihat. | crude w. bancrofti microfilarial and l. carinii adult antigens were tried in elisa and ihat for immunodiagnosis of bancroftian filariasis. both tests gave a higher positive reactions with microfilaraemic, clinical filariasis and endemic normal sera respectively. elisa using w. bancrofti microfilarial antigen appears to be more sensitive. | 1992 | 1578155 |
| detection of microfilariae in cervical cytology. | 1992 | 1580134 | |
| tropical pulmonary eosinophilia. | tropical pulmonary eosinophilia is one of the many pie syndromes [pulmonary infiltrates with eosinophilia (of the peripheral blood)]. it is caused by immunologic hyperresponsiveness to the filarial parasites wuchereria bancrofti or brugia malayi. its clinical presentation includes nocturnal cough, dyspnea, wheezing, fever, weight loss, fatigue, interstitial mottling on chest radiograph, predominantly restrictive but also obstructive lung function abnormalities, and peripheral blood eosinophilia ... | 1992 | 1580599 |
| kinetics of circulating human igg4 after diethylcarbamazine and ivermectin treatment of bancroftian filariasis. | patent filarial infections are associated with elevated levels of parasite-specific igg4. this study investigated the shifts of filarial-specific human igg and igg4 antibodies after diethylcarbamazine and ivermectin treatment of bancroftian filariasis. thirty adult haitians were treated first with a 1-mg clearing dose of ivermectin and then with either one or two 200-micrograms/kg doses of ivermectin or with 12 daily 6-mg/kg doses of diethylcarbamazine. posttreatment levels of antifilarial igg4 ... | 1992 | 1583340 |
| on the infectivity of early third-stage brugia larvae isolated from the abdomen of aedes aegypti. | third-stage larvae (l3) of wuchereria bancrofti, brugia malayi and b. pahangi are known to be recovered not only from the head and thorax but also from the abdomen of dissected vector mosquitoes. for epidemiological reasons, was of interest to determine whether l3 larvae from the abdomen of the vector would be infectious for the final host. early abdominal l3 larvae of b. pahangi isolated as early as on day 7 post-infection (p.i.) from aedes aegypti were injected s.c. into five male meriones ung ... | 1992 | 1584752 |
| the wellcome trust lecture. infection and disease in lymphatic filariasis: an immunological perspective. | the basic tenet of the immunological perspective of filarial disease is that differential immune responsiveness among individuals exposed to infection results in the different clinical manifestations that develop. the mechanisms involved in this differential responsiveness appear to reflect different t-cell cytokine response patterns. asymptomatic patients with the clinically silent presentation of 'asymptomatic microfilaraemia', who have been previously described as being 'immunosuppressed' wit ... | 1992 | 1589302 |
| infection and disease in lymphatic filariasis: an epidemiological approach. | 1992 | 1589303 | |
| wuchereria bancrofti microfilarial density of autochthonous cases and natural culex infectivity rates in northeast brazil. | autochthonous wuchereria bancrofti microfilaraemic cases from three neighbouring cities of northeast brazil (recife, jaboatao and olinda) were selected from thick smear or filtration positive individuals and classified by their microfilarial (mf) densities through polycarbonate membrane blood filtration. individuals were subdivided into two groups: autochthonous cases without any previous specific drug administrations (group a) and those with one or more previous dec treatments (group b). in rec ... | 1992 | 1597880 |
| release of prostaglandin e2 by microfilariae of wuchereria bancrofti and brugia malayi. | to elucidate the local release of immunomodulatory prostaglandins by intravascular filarial parasites, the formation of prostaglandin e2 (pge2) was examined in individual microfilariae of wuchereria bancrofti and brugia malayi. following incubation of living microfilariae immobilized in an agar matrix, prostaglandins released by the parasites were fixed by carbodiimide and localized by indirect immunofluorescence. prostaglandin e2 was specifically detected around the entire surface of microfilar ... | 1992 | 1599045 |
| bancroftian filariasis in pondicherry, south india--epidemiological impact of recovery of the vector population. | an integrated vector management (ivm) strategy was implemented from 1981 to 1985 in one part of pondicherry, south india, for the control of the bancroftian filariasis vector culex quinquefasciatus (the ivm area). the rest of the town (the comparison area) received the conventional larvicidal input. after 1985 both the areas were managed conventionally. the switch to conventional strategy resulted in an increase of vector density in both areas. the microfilaraemia prevalence in humans showed a g ... | 1992 | 1601082 |
| renal abnormalities in microfilaremic patients with bancroftian filariasis. | to determine the frequency of renal abnormalities occurring with bancroftian filarial infections and to assess the effects of treatment on such abnormalities, we initiated a prospective, hospital-based study of 20 microfilaremic and five amicrofilaremic patients with wuchereria bancrofti infections. thorough clinical evaluations and detailed renal assessments were made prior to treatment and at multiple time points for 60 days following a standard twelve-day course of treatment with diethylcarba ... | 1992 | 1621900 |
| cloning and characterization of the wuchereria bancrofti s15 ribosomal protein. | 1992 | 1625701 | |
| induced polypeptides associated with filarial worm refractoriness in aedes aegypti. | brugia malayi and wuchereria bancrofti are mosquito-borne parasitic nematodes responsible for lymphatic filariasis in approximately 90 million people. the genetic control of the susceptibility of aedes aegypti mosquitoes to b. malayi was well defined 30 years ago, but no data have since been provided regarding the gene products responsible for susceptibility or refractoriness or both. we addressed this problem by assessing polypeptide synthesis in thoracic tissue, the developmental site of this ... | 1992 | 1631149 |
| filarial infection of the breast. report of a case with diagnosis by fine needle aspiration cytology. | the breast is not a frequent site of filarial infection. we report a case of fine needle aspiration cytologic diagnosis of filariasis of the breast, not previously reported. | 1992 | 1636341 |
| breast filariasis diagnosed by needle aspiration cytology. | a case of nodular lesion of the breast in a 37 year old female caused by filariasis is described. the case is instructive since the diagnosis was made by fine-needle aspiration cytology. | 1992 | 1638940 |
| isozymic pattern of lactate dehydrogenase in cases of bancroftian filariasis. | isozymic patterns of lactate dehydrogenase (e.c. 1.1.1.27) by polyacrylamide gel electrophoresis (page) were observed in various categories of filariasis and controls, i.e. asymptomatic microfilaraemia and symptomatic amicrofilaraemia, endemic normal and non-endemic normal. lactate dehydrogenase (ldh) activity was also observed amongst the above categories of patients. an increase in enzyme activity and change in the isozymic pattern was observed in the above categories of filaria infected serum ... | 1992 | 1640089 |
| clinical manifestations of filariasis in fujian, china. | 1992 | 1641878 | |
| mebendazole with levamisole in tropical pulmonary eosinophilia: an alternative in diethylcarbamazine allergy. | 1992 | 1641900 | |
| intensity and efficiency of transmission and the development of microfilaraemia and disease: their relationship in lymphatic filariasis. | currently available methods for measuring the intensity of transmission in the lymphatic filariases are all to some extent unsatisfactory. clinical methods for defining the presence of filarial disease are also less than perfect, and many infected persons remain free of symptoms and signs for very long periods. incidence rates of microfilaraemia calculated from prevalence rate data are combined with 'entomological inoculation rates' obtained by direct observations of vector landing rates, infect ... | 1992 | 1740813 |
| evaluation of fractionated circulating filarial antigen in diagnosis of bancroftian filariasis. | circulating filarial antigen (cfa) isolated from the plasma of microfilaraemic patients was fractionated on an ultrogel aca 34 column. the second protein peak (cfa2) showing filarial antigen was further fractionated by deae-cellulose column chromatography into two fractions (cfa2 de1 and de2). cfa2 de1 fraction, showing antigenic activity, was further evaluated in an elisa for its diagnostic use in bancroftian filariasis. studies with cfa2 de1 and anti-cfa2 de1 antibody showed that they were hig ... | 1992 | 1740819 |
| characterization of a myosin heavy chain gene from brugia malayi. | we have previously shown that an antigen recognized by antibodies in sera of several microfilaremic individuals from a wuchereria bancrofti endemic area bears strong homology to an invertebrate muscle protein. we have cloned and sequenced the entire gene containing this antigen encoding fragment and present data that confirms that the antigen is myosin heavy chain (mhc). this gene, which we have named bmmyo-1 extends over 11 kb and has the potential to encode a protein of 1957 amino acids. the c ... | 1992 | 1741013 |
| lack of igg4 antibody response to carbohydrate antigens in patients with lymphatic filariasis. | it has been suggested that humans are genetically restricted from making igg4 antibody responses to carbohydrate antigens. to test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of igg4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their igg and igg subclass responses to streptococcal protein [streptolysin-o (so), deoxyribonucleas ... | 1991 | 1748481 |
| circulating immune complexes and complement in bancroftian filariasis. | sixty filarial cases, 30 endemic normal individuals and 10 non endemic subjects were investigated for the presence of circulating immune complexes (cics) and complement component c3. using polyethylene glycol precipitation and polyethylene glycol precipitation-complement consumption methods, it was observed that cics were raised significantly in chronic lymphatic filariasis and tropical pulmonary eosinophilia (tpe) groups. the results observed by both the techniques for detection of cics were co ... | 1991 | 1752648 |
| a quantitative approach to the relationship between wuchereria bancrofti microfilaria counts by venous blood filtration and finger-prick blood films. | counts of nocturnally periodic wuchereria bancrofti microfilariae (mf) in 20 mm3 finger-prick blood films were compared with membrane counts after filtration of 1 ml of venous blood for their efficacy in determining the prevalence of bancroftian filariasis. the technique used for spreading and staining the blood films was critically important to the sensitivity of this screening procedure. there was good agreement between the 2 methods. four statistical approaches were used to measure the correl ... | 1991 | 1755060 |
| bancroftian filariasis: long-term effects of treatment with diethylcarbamazine in a haitian population. | two groups of wuchereria bancrofti-infected haitians who had undergone treatment with diethylcarbamazine (dec) were followed for up to five years after treatment to document the long-term effects of treatment on adult worms and microfilariae and on the recurrence of infection. one group of 69 persons who had received 12 daily treatments had a significant decrease in microfilaria levels until year 4, when a small number of individuals experienced a resurgence of this parasite stage in the periphe ... | 1991 | 1763800 |
| antigenic similarity between the mosquito vectors of malaria and filariasis. | rabbit antisera were raised to the malaria vector anopheles tessellatus, head-thorax, abdomen, and midgut preparations. reactivity of the antisera with an. tessellatus and the filariasis vector, culex quinquefasciatus, were examined by enzyme-linked immunosorbent assay (elisa) and western blots. although many antigens were shared between the two species of mosquitoes, tissue- and species-specific antigens also were identified. | 1991 | 1770509 |
| a placebo-controlled double-blind trial for the treatment of bancroftian filariasis with ivermectin or diethylcarbamazine. | therapeutic efficacy and clinical side-effects of ivermectin (single dose of 100 micrograms/kg) and diethylcarbamazine (dec) (3 mg/kg for one day, then 6 mg/kg daily for 12 d) were evaluated for microfilaricidal effect in bancroftian filariasis. seventy-one microfilaraemic consenting adult male patients (greater than or equal to 100 microfilariae (mf)/ml) were randomly assigned to receive ivermectin, dec or placebo and kept in hospital for 15 d. those receiving placebo were treated with ivermect ... | 1991 | 1780996 |
| anopheles (cellia) jamesii: a potential natural vector of bancroftian filariasis in sri lanka. | 1991 | 1780997 | |
| human disease caused by dog heartworm. | pulmonary infection with d. immitis is an infrequently reported cause of lung disease in humans. approximately 80 cases have been reported in the united states, with increasing numbers reported in recent years. the largest single series from one institution is a series of 6 patients from ochsner clinic in new orleans, louisiana. although our series consisted of 3 females and no males, the disease is detected and diagnosed in males twice as often. the usual age range is 40 to 60 years. no case ha ... | 1991 | 1784039 |
| oral infection of aedes polynesiensis by wuchereria bancrofti by using parafilm membrane feeding. | in order to construct a cdna library from third-stage larvae (l3) of wuchereria bancrofti var. pacifica, the parafilm membrane feeding method is proposed for the oral infection of aedes polynesiensis. heparinized blood supplemented with 5.10(-3) m atp was put in the feeder with carbon dioxide provided as additional phagostimulant. the results of this artificial infection feeding method were compared with those obtained when mosquitoes fed directly on the forearm of a microfilaremic patient. the ... | 1991 | 1787414 |
| vascular abnormalities in experimental and human lymphatic filariasis. | whereas clinical descriptions of grotesque lymphedema and standard light microscopy in human filariasis have elucidated the natural progression of this disease, the link between the nematode and vascular abnormalities including elephantiasis remains poorly understood. accordingly, we examined the nature and distribution of lymphatic and blood vascular derangements in a variety of tissues and organs from 37 ferrets acutely and chronically infected with brugia malayi and in 15 patients with wucher ... | 1991 | 1791728 |
| effect of diethylcarbamazine on the alveolitis of tropical eosinophilia. | bronchoalveolar lavage studies in 33 patients with acute untreated tropical eosinophilia have demonstrated intense eosinophilic alveolitis. following treatment with a standard 3-week course of diethylcarbamazine, there was a significant fall in lung eosinophils (p less than 0.001). however, a mild alveolitis characterised by hypercellular lavage fluid due to a significant increase in absolute alveolar macrophages (p less than 0.001) and due to an increase in both the absolute number (p less than ... | 1991 | 1792413 |
| single versus repeated doses of ivermectin and diethylcarbamazine for the treatment of wuchereria bancrofti var. pacifica microfilaremia. results at 12 months of a double-blind study. | in october 1989, 58 apparently healthy polynesian wuchereria bancrofti carriers in whom microfilarial (mf) density was greater than or equal to 100 mf/ml were randomly allocated to treatment groups receiving single doses of either ivermectin at 100 mcg/kg or diethylcarbamazine (dec) at 3 and 6 mg/kg. six months later, half of the carriers initially treated with ivermectin 100 mcg/kg or dec 3 mg/kg were given a second similar dose while the rest were given a placebo. by day 360 (6 months after re ... | 1991 | 1796228 |
| diagnostic values of elisa-igg4 as compared to elisa-igg and indirect immunofluorescence, for the routine diagnosis of bancroftian filariasis in the south pacific. application on capillary blood collected on filter paper. | for the serodiagnosis of lymphatic filariasis, serological assays restricted to the detection of specific igg4 antibodies enhanced the specificity. in french polynesia, wuchereria bancrofti is the sole human filaria and other pathogenic parasites are infrequent. in order to define a simple and cheap serological test, we have compared the diagnostic value of indirect immunofluorescence test (ifi-wbp), elisa-igg and elisa-igg4 assays. the specificity, sensitivity, r.o.c. curves of each test have b ... | 1991 | 1796229 |
| cumulative mortality rates in aedes polynesiensis after feeding on polynesian wuchereria bancrofti carriers treated with single doses of ivermectin, diethylcarbamazine and placebo. | during a therapeutic trial, batches of 672 to 1979 laboratory-bred aedes polynesiensis, the mosquito vector of lymphatic filariasis in french polynesia, were fed on wuchereria bancrofti carriers one, three and six months after they had been treated with either single doses of ivermectin at 100 mcg/kg, diethylcarbamazine (dec) at 3 and 6 mg/kg or placebo. high mortality rates were observed during the 15-day period following the blood-meal in mosquitoes fed on carriers treated with microfilaricida ... | 1991 | 1796230 |
| in vitro differentiation of wuchereria bancrofti (filariidae). | wuchereria bancrofti microfilariae were isolated from blood of infected individuals and cultured in vitro under several conditions. rpmi 1640 and tc-199 media supplemented with fetal or human serum were able to support the microfilariae for periods up to 35 days at 37 degrees c (viability greater than 85%). in contrast, in minimal essential medium the microfilariae did not survive for more than 48 h. in cultures kept at 28 degrees c, where viability was much lower (approximately 10% on day 15), ... | 1991 | 1797253 |
| biting periodicity index of culex quinquefasciatus & its relationship with microfilaria periodicity in pondicherry. | the biting periodicity index of the bancroftian filariasis vector, c. quinquefasciatus, was calculated on the basis of a large longitudinal data base and compared with the periodicity index of microfilariae of wuchereria bancrofti. the biting periodicity index of the vector population was 29.78 and found to be close to the periodicity index of the microfilariae. the peak biting activity of the vector and peak appearance of microfilariae in the peripheral blood occurred at about 01.00 h, which ac ... | 1991 | 1797648 |
| the adhesion phenomenon in filariasis: a preliminary note. 1928. | 1991 | 1797651 | |
| filariasis in gongola state nigeria. i: clinical and parasitological studies in mutum-biyu district. | a total of 2552 persons living in 9 villages along the benue river valley, mutum-biyu district of gongola state, nigeria were examined between october and december 1989 for filariasis. it is the first time a filariasis survey will be carried out in this state. 276 (10.8%) had wuchereria bancrofti, 50 (2.0%) had loa loa, 281 (11.0%) were positive for mansonella perstans while 12 (0.5%) were positive for onchocerca volvulus. villages located near the benue river had higher prevalence rates than th ... | 1991 | 1804869 |
| pattern of wuchereria bancrofti microfilaraemia in young and adolescent school children in bassein, india, an endemic area for lymphatic filariasis. | 1991 | 1811444 | |
| filaria situation in the union territory of dadra & nagar haveli. | a resurvey conducted 8 years later in the union territory of dadra & nagar haveli revealed the persistence of filariasis amongst its residents. though no control measures have been in operation since the detection of filariasis in dadra and nagar haveli in 1982, the parasitological indices, microfilaria (mf) and disease rates as well as mf count have remained static. the entomological studies revealed five times increase in density of culex quinquefasciatus both in silvassa and naroli towns. | 1991 | 1812163 |
| some epidemiological and clinical aspects of bancroftian filariasis in coastal andhra pradesh. | 1991 | 1821887 | |
| molecular cloning and characterization of recombinant parasite antigens for immunodiagnosis of onchocerciasis. | immunological cross-reactivity among nematodes has hampered the development of specific serodiagnostic assays for onchocerciasis. in the present study, an onchocerca volvulus adult worm complementary dna expression library was differentially screened with human sera from patients infected with o. volvulus and with an omnibus anti-nematode serum pool comprised of sera from patients infected with brugia malayi, loa loa, wuchereria bancrofti, mansonella perstans, strongyloides stercoralis, ancylost ... | 1991 | 1840605 |
| autochthonous wuchereria bancrofti microfilaremia in the city of maceió, alagoas-brazil. | 1991 | 1842450 | |
| [transplacental passage of wuchereria bancrofti microfilariae in newborns of microfilaremic mothers]. | the occurrence of circulating wuchereria bancrofti microfilariae was investigated in 304 pregnant women from the "unidade mista pof. barros lima" and "hospital das clínicas/ufpe". the filtration technique was employed to detect microfilaraemia during pregnancy, and 13 women were found to be positive (4.2%). the investigation of microfilariae in the cord blood of their children was negative (6/13), and also in venous blood samples collected up to 72 hours after birth and with 6 months of life. mi ... | 1991 | 1844389 |
| [evaluation of the indirect immunofluorescence test for the diagnosis of bancroftian filariasis using microfilariae w. bancrofti as the antigen, in recife-pe, brazil]. | the authors analysed the indirect immunofluorescence assay, for the diagnosis of bancroftian filariasis using papain treated w. bancrofti microfilariae as antigen, widely used in recife-brazil. sera from 50 patients with several clinical forms of the disease including asymptomatic carriers, tropical pulmonary eosinophilia, elephantiasis, filarial fever and chyluria were analysed. for the control group, 50 individuals were selected, living at least 5 years in endemic area, with neither previous d ... | 1991 | 1844968 |
| age-specific acquisition of immunity to infective larvae in a bancroftian filariasis endemic area of papua new guinea. | the development of antibodies to infective stages of the filarial parasite, wuchereria bancrofti, with age of the host human population was studied by immunofluorescence, immunoprecipitation and immunoblotting assays. among individuals under 20 years of age, few had detectable antibodies to the infective (l3) larval surface by ifa: only 2 out of 10 scored positive. however, all adults (over 20 years) were positive in this assay although the utilization of isotypes varied between different indivi ... | 1991 | 1852475 |
| a recombinant clone of wuchereria bancrofti with dna specificity for human lymphatic filarial parasites. | in order to understand the immune response to wuchereria bancrofti and to aid in the diagnosis of w. bancrofti infections, recombinant antigens were identified from a w. bancrofti genomic expression library made in lambda gt11 using a pool of sera from infected indian patients. one of the recombinant clones, lambda wbn1, containing a 2.5-kb insert, reacted strongly to a pool of sera from patients with lymphatic filariasis but not to normal human sera. in addition, this clone showed restricted sp ... | 1991 | 1857386 |
| evaluation of a monoclonal-antibody based antigen assay for diagnosis of wuchereria bancrofti infection in egypt. | conventional methods for diagnosis of wuchereria bancrofti infection are insensitive and often impractical because of the need for night blood collections. a sensitive and specific antigen detection assay has been developed for w. bancrofti, which is based on a monoclonal antibody (ad12) that binds to a repeated epitope on a 200 kda adult worm excretion product present in sera from infected humans. the only formal evaluation of this assay to date was performed with sera from india. in the presen ... | 1991 | 1858970 |
| [observation on the behavior of microfilariae in human filariasis]. | a total of 19 female adult filariae containing microfilariae in uteri collected from 25 filariasis patients were examined. light transmission microscopic observations showed: (1) some of the adult worms entered the lumen of blood vessels by penetrating the venous wall and discharged immature and mature microfilariae and embryos into the blood stream; (2) microfilariae developed into maturation in the uterus of adult female worms, but when the adult worm began to degenerate, the microfilariae did ... | 1991 | 1873886 |
| [advances in filariasis control and research in china during 1986-1990. national technical steering group for filariasis control and research, moph]. | based upon the statistical data during 1986-1990 from provincial, regional or municipal institutions involved in the control and research of filariasis, important achievement in filariasis control has been achieved since 1986. during the 5 years, 22,350,772 person were blood-examined, among them, 268,034 were found to be microfilaria positive; a total of 78,550,945 man/times of treatment with dec were given (including administration of dec-medicated salt). till the end of 1990, filariasis has be ... | 1991 | 1873890 |
| major achievements and experience in filariasis control in the people's republic of china. national technical steering group for filariasis control and research. | filariasis control including a preparatory phase in the early 50s and two more extensive campaigns in the late 50s and 70s, has gained remarkable achievements. by the end of 1987, filariasis in 781 (90.4%) of 864 counties/cities was brought under control, i.e., the microfilariasis rate declined to less than 1% in the whole population in every village concerned. at present, there remain about 2,446,000 filariasis cases, accounting for 7.9% of 30,099,400 before nationwide campaigns. microfilaria c ... | 1991 | 1874020 |
| suppression of con a induced lymphocyte transformation by sera from filarial patients with clinical manifestations. | reduced lymphocyte transformation to wuchereria bancrofti microfilariae excretory-secretory antigen and con a were observed in clinical filarial patients. pre-incubation of normal human peripheral blood mononuclear cells with sera from filarial patients with clinical manifestations such as hydrocele and elephantiasis suppressed con a induced responses. effect of fractionated clinical filarial serum on con a induced lymphocyte transformation showed that the inhibitory activity was associated with ... | 1991 | 1874552 |
| tropical pulmonary eosinophilia. | 1991 | 1876877 | |
| efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. i. clinical and parasitologic observations. | we compared the efficacy of a single dose of ivermectin with that of a standard course of diethylcarbamazine (dec) for the control of microfilaremia in 60 patients with bancroftian filariasis who had developed recurrent microfilaremia after each of three or more prior treatments with dec. the study was done as a randomized, double-blind trial. complete, but in some cases, transient clearance of microfilaremia was observed in both treatment groups. at one year, recurrent microfilaremia was presen ... | 1991 | 1877711 |
| efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. ii. immunologic changes following treatment. | we compared the effect of a single dose of ivermectin with that of a standard course of diethylcarbamazine (dec) on several parameters of the host's antifilarial immune response in 60 patients with bancroftian filariasis enrolled in a double-blind drug trial. all participants had measurable serum levels of antifilarial antibodies and parasite antigens at the onset of the study. drug-induced clearance of microfilaremia was associated with a temporary increase in hc 11 antigenemia and a decrease i ... | 1991 | 1877712 |
| monitoring of filarial antigens in jirds and patients after treatment. | we developed a sandwich elisa with monoclonal antibodies to monitor filarial antigens in animals and patients after infection and treatment. levels of antimicrofilarial antibodies and parasite antigens were measured periodically in 40 b. malayi infected jirds. in all animals l3 hc11 antigen was detected earlier than mf es34 antigen, while antimicrofilarial antibodies appeared much more slowly. these serologic changes precede the onset of patent infections. after 3 courses of treatment with dec a ... | 1991 | 1879215 |
| asymptomatic eosinophilic myocarditis: 2 + 2 = 4 or 5! | a twenty-eight year old man was admitted with a cerebrovascular accident and hypereosinophilia secondary to microfilarial infection. endomyocardial biopsy revealed focal eosinophilic myocarditis. the intriguing presence of this asymptomatic myocarditis raises interesting possibilities. | 1991 | 1879984 |
| can anopheline-transmitted filariasis be eradicated? | 1991 | 1880825 | |
| the significance of low density microfilaraemia in the transmission of wuchereria bancrofti by culex (culex) quinquefasciatus say in sri lanka. | laboratory-bred culex quinquefasciatus were fed on carriers with low and moderate densities of microfilariae (mf) of wuchereria bancrofti. in the first series of experiments, mosquitoes were dissected 12 d after feeding. the percentage of infected mosquitoes and the numbers of larvae per infected mosquito were directly proportional to the mf density at the time of feeding. there was an overall high infection rate and a wide distribution of larvae per individual mosquito at all levels, except for ... | 1991 | 1887486 |
| the dynamics of infection and disease in bancroftian filariasis. | this study examines the relationship between the dynamic of wuchereria bancrofti infection and the development of chronic lymphatic disease. data sets from pondicherry, south india, and calcutta are used to estimate the age-specific proportion of the endemic population which has converted from microfilaria positive to amicrofilaraemia, and is assumed to be at risk of disease. for men, but not women, the age-prevalence profile of the estimated population 'at risk' is shown to correspond closely t ... | 1991 | 1887487 |
| clinical epidemiology of bancroftian filariasis: effect of age and gender. | a cross-sectional survey was used to determine the prevalence of disease (n = 6493) and microfilaraemia (n = 24,946) due to wuchereria bancrofti in pondicherry, south india. the total disease attributable to filariasis was significantly higher in males (13.67%) than females (2.26%), due to the occurrence of hydrocele in males. while the prevalence of chronic signs was clearly age-dependent in both sexes, that of acute signs was independent of age. thus the age and gender structure of the survey ... | 1991 | 1887488 |
| filariasis in ceylon then (1961) and in sri lanka now (1990-30 years on). | the changes in the prevalence and distribution of bancroftian filariasis in ceylon/sri lanka since professor kershaw's visit in 1961 show that the infection has spread over a wider area, although the microfilaria rates have decreased. new information is available on the vector, culex quinquefasciatus, and more details are available on the animal filariae and their vectors. dirofilaria repens infection of dogs is now a proven zoonosis in the country. | 1991 | 1888209 |
| antifilarial cellular responses detected in a haitian pediatric population by use of a microblastogenesis assay. | previous reports have demonstrated age-related shifts in antifilarial humoral immune responses in 6- to 10-year-old haitian children; the responses consisted of elevated parasite-specific igg2 and igg3 in amicrofilaremic children and elevated igg4 in microfilaremic children. in this study, the cell-mediated immune responses to soluble adult and microfilarial extracts of brugia pahangi, determined by use of a microblastogenesis assay, were examined. capillary blood samples were collected by finge ... | 1991 | 1894942 |
| changes in circulating parasite antigen levels after treatment of bancroftian filariasis with diethylcarbamazine and ivermectin. | this study assessed changes in circulating parasite antigen levels after diethylcarbamazine (dec) and ivermectin treatment of bancroftian filariasis to determine effects of these drugs on adult wuchereria bancrofti in vivo. thirty adult haitians with microfilaremia were treated with 1 mg of ivermectin to reduce counts of microfilariae. later, subjects were treated with either one or two 200 micrograms/kg doses of ivermectin or with 12 daily 6 mg/kg doses of dec. macrofilaricidal activity of thes ... | 1991 | 1894943 |
| human natural antibodies to culex quinquefasciatus: age-dependent occurrence. | the titer of anti-culex quinquefasciatus antibodies which were mostly of igg and ige isotypes was determined in humans living in wuchereria bancrofti endemic regions. a progressive increase in the titer of antibodies was observed with age. in contrast, sera from people living in regions where the cx. quinquefasciatus is of low prevalence were found to have markedly reduced igg and almost zero ige levels. | 1991 | 1895094 |
| detection of wuchereria bancrofti specific antigens in the serum of endemic residents. | a sandwich enzyme-linked immunosorbent assay (s-elisa) is developed for detecting circulatory antigens in individuals infected with wuchereria bancrofti in an endemic area using antibody (ig) against excretory-secretory-metabolic antigens of the microfilariae raised in rabbit (anti-mf-esm) and labelled with alkaline phosphatase (esm-ig-conjugate). an optical density reading of a sample greater than 0.075 (after subtracting the background) was taken as positive in the s-elisa. when homologous (wb ... | 1991 | 1896764 |
| cdna clones of onchocerca volvulus low molecular weight antigens provide immunologically specific diagnostic probes. | we report here a panel of cdna clones from onchocerca volvulus which were isolated on the basis of being uniquely recognised by onchocerciasis sera and not by sera from patients infected with the major lymphatic filarial nematode parasite wuchereria bancrofti. over 90% of o. volvulus recombinants from a primary screen were found to cross-react with lymphatic filariasis sera and were discarded. the subset of specific clones, selected with pooled sera, was then screened with panels of individual p ... | 1991 | 1922197 |
| bancroftian lymphadenopathy: a histopathologic study of fifty-eight cases from northeastern brazil. | histologic study of bancroftian lymphadenopathy in 58 patients originating from an endemic area revealed a wide range of tissue reactions to the filarial worms. in seven patients (12.0%), no attendant inflammation or parasite damage was observed. a mild-to-intense nongranulomatous chronic lymphangitis was found in 12 patients (20.7%). granulomatous reactions with variable composition were the most common pattern observed (37 patients, 63.8%); fibrotic lesions containing calcified worms were pres ... | 1991 | 1928566 |
| long term effect of diethylcarbamazine medicated common salt on bancroftian filariasis. | 1991 | 1940217 | |
| bilateral excision of perinephric fat and fascia (gerota's fasciectomy) in the treatment of intractable chyluria. | a case is described of a 59-year-old black man with massive chyluria, probably due to previous infection with wuchereria bancrofti. notably, no edema was present despite a urinary protein loss of 40 gm. per day resulting in a serum albumin level of 13 gm./l. conservative treatment after lymphography, including prolonged bedrest and a medium chain triglyceride diet, was unsuccessful. bilateral excision of the perinephric fascia and fat (gerota's fasciectomy) in 2 separate operative sessions final ... | 1991 | 1942297 |
| control of filariasis. | 1991 | 1948270 | |
| filariasis and its control in fujian, china. | epidemiological survey of filariasis in fujian province, china showed that malayan filariasis, transmitted by anopheles lesteri anthropophagus was mainly distributed in the northwest part and bancroftian filariasis with culex quinquefasciatus as vector, in middle and south coastal regions. both species of filariae showed typical nocturnal periodicity. involvement of the extremities was not uncommon in malayan filariasis. in contrast, hydrocele was often present in bancroftian filariasis, in whic ... | 1991 | 1948271 |
| evaluation of bacillus sphaericus formulations against the vector of bancroftian filariasis. | three different formulations of bacillus sphaericus viz, spherimos, vectobac and spherifix, were evaluated for their efficacy and residual activity against culex quinquefasciatus breeding in polluted disused wells. spherimos, a flowable concentrate formulation, exerted 96-100% control when treated at the dosage of 10 l/ha for 17 days, whereas the effective residual activity lasted up to 67 days at 15 l/ha. in the case of vectolex, a granular formulation, the residual activity lasted up to 56 day ... | 1991 | 1948272 |
| bancroftian microfilariasis in association with pulmonary tuberculosis. report of a case with diagnosis by fine needle aspiration. | a 25-year-old man presented with clinical and radiologic features suggestive of pulmonary tuberculosis. since the examination of ziehl-neelsen-stained sputum smears for acid-fast bacilli was repeatedly negative, a transthoracic fine needle aspiration biopsy was performed. papanicolaou-stained smears of the aspirate showed microfilariae of wuchereria bancrofti and a tuberculous exudate but no acid-fast bacilli or classic granulomas. subsequent sputum samples did show acid-fast bacilli, while a no ... | 1991 | 1950321 |
| [secondary amyloidosis in amebiasis with intrathoracic complications of amebic liver abscess combined with helminthiases and maduromycosis]. | one case of a secondary amyloidosis in amebiasis with intrathoracic complications of amebic liver abscesses in association with strongyloidiasis, enterobiasis, bancroftian filariasis and maduromycosis is described. it's suggested that the progression of secondary amyloidosis was due to the prolonged process of amebiasis in association with helminthiasis and mycosis. | 1991 | 1953364 |
| animal hosts in experimental lymphatic filariasis research. | 1991 | 1958103 | |
| the treatment of microfilaremia due to wuchereria bancrofti var. pacifica: ivermectin versus diethylcarbamazine]. | in october 1989, a controlled, double-blind parallel group trial was implemented to compare both efficacy and tolerability of single doses of ivermectin and diethylcarbamazine (dec). fifty eight apparently healthy wuchereria bancrofti carriers were hospitalized and randomly allocated to treatment with ivermectin 100 mcg/kg, dec 3 or 6 mg/kg. six months later, half of those initially treated with ivermectin 100 mcg/kg and dec 3 mg/kg were given a second similar dose while the rest were given a pl ... | 1991 | 1958108 |
| experimental infection of humans with filariae. | this report summarizes the findings of the 17 published studies involving humans who have been experimentally infected with filarial parasites. over the past 60 years, 45 individuals have been deliberately infected with wuchereria bancrofti, brugia malayi, brugia pahangi, loa loa, mansonella perstans, mansonella ozzardi, and/or onchocerca volvulus. the findings from these experimental infections of humans have helped define microfilarial survival and periodicity within human hosts, the prepatent ... | 1991 | 1962076 |
| maternal filarial infection as risk factor for infection in children. | familial clustering of filarial infection was investigated through random house-to-house surveys of 643 individuals in leogane, haiti, an area with endemic bancroftian filariasis. children of infected mothers were 2.4 to 2.9 times more likely to be infected than were those of amicrofilaraemic mothers. filarial-specific cellular responsiveness in amicrofilaraemic children born to infected mothers was lower than that in amicrofilaraemic children born to amicrofilaraemic mothers. no effect of pater ... | 1991 | 1673168 |
| humoral immune response to infective larval antigen in brugia malayi infected mastomys natalensis. | the sequential changes in the humoral immune response against infective larval antigens during the course of brugia malayi infection in mastomys natalensis have been studied using enzyme linked immunosorbent assay. igm antibody against b. malayi infective larval excretory secretory (es) antigen was detected in the peripheral circulation within a week of infection, whereas igm antibody against b. malayi infective larval somatic antigen and igg antibody against both somatic and es antigens were de ... | 1991 | 1674404 |
| detection of amplified wuchereria bancrofti dna in mosquitoes with a nonradioactive probe. | a technique to identify wuchereria bancrofti larvae in mosquito vectors with an enzyme-labeled dna probe is described. to overcome the low sensitivity of nonradioactive detection methods, analyte dna was amplified by polymerase chain reaction (pcr). oligonucleotide primers were used to amplify w. bancrofti-specific dna fragments of 380 and 650 bp, respectively. parasite dna in mosquito extracts was isolated free of inhibitors of the pcr by hybridization to a biotinylated dna fragment (iwb 67), w ... | 1991 | 1675761 |
| elephantiasis in early polynesia. | 1991 | 1680896 | |
| the filariasis situation in guangdong province, china. | this paper describes the general situation, historical perspectives, epidemiological surveys (including geographical distribution, microfilarial rate, microfilarial rate in different age groups, clinical features, animal filaria, periodicity of wuchereria bancrofti and vector species), experimental research and control of filariasis in guangdong province, china. | 1991 | 1687930 |
| ivermectin inhibits molting of wuchereria bancrofti third stage larvae in vitro. | the effect of ivermectin or diethylcarbamazine (dec) on wuchereria bancrofti molting from the third to the fourth larval stage (l3 to l4) was evaluated in vitro. l3 larvae were harvested from laboratory-reared aedes togoi 2 wk after feeding upon a microfilaremic human volunteer. the larvae were kept in an artificial medium (franke's ni medium) with 10% human serum under an atmosphere of 5% co2 for 20 days. experimental tubes also contained ivermectin (0.1-1,000 ng/ml) or dec (0.1-10,000 ng/ml). ... | 1991 | 1992087 |
| comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in haiti. | this three-phase study was designed to compare high dose ivermectin with a standard diethylcarbamazine (dec) regimen for patient tolerability, potential to kill adult filaria, and duration of microfilarial suppression in 30 haitian subjects with wuchereria bancrofti microfilaremia. all were first given a 1-mg oral dose of ivermectin (phase 1) to reduce microfilaria densities. participants were randomized into three groups: group 1 received dec (6mg/kg per day for 12 days), group 2 received 200 m ... | 1991 | 1996738 |
| analysis of isotype-specific antifilarial antibody levels in a haitian pediatric population. | previous studies of antifilarial antibodies in a pediatric population residing in an area with endemic wuchereria bancrofti filariasis have demonstrated age related shifts in antifilarial immunity. to further characterize humoral responses in haitian children, serum samples from 129 patients (3 months-15 years of age) were analyzed by elisa for isotype-specific antifilarial antibody responses. age-stratified analysis of geometric mean antibody titers showed significant increases in antibody tite ... | 1991 | 2012259 |
| evidence of nonsusceptibility to diethylcarbamazine in wuchereria bancrofti. | this study assessed wuchereria bancrofti-infected patients who received diethylcarbamazine (dec) to determined if drug levels were comparable between individuals who continued to harbor circulating microfilariae and those whose blood became clear of parasites, between those with high and low microfilaria counts, and between infected and noninfected persons. haitian volunteers undergoing treatment for w. bancrofti and two nonendemic controls were enrolled. dec levels in serum and urine samples we ... | 1991 | 2019765 |
| c-reactive protein in patients with lymphatic filariasis: increased expression on lymphocytes in chronic lymphatic obstruction. | levels of c-reactive protein (crp) were evaluated by enzyme immunoassay in patients infected with the filarial parasite wuchereria bancrofti. significantly elevated levels of crp (p less than 0.001) were demonstrated in patients with chronic lymphatic pathology (cp; n = 18) compared to patients with asymptomatic microfilaremia (mf; n = 13) and normal volunteers (nv; n = 29). serum levels of crp showed an inverse correlation (rs = -0.37; p less than 0.05) with phosphocholine (pc)-containing filar ... | 1991 | 2022721 |
| incidental detection of microfilariae in cytological smears: clinical examples. | incidental detection of microfilariae of w. bancrofti in fine-needle aspiration and imprint cytology smears is reported in patients referred for some unrelated complaints. | 1991 | 2023286 |