Publications

drug-induced thrombotic microangiopathy: incidence, prevention and management.	the term thrombotic microangiopathy (tma) describes syndromes characterised by microangiopathic haemolytic anaemia, thrombocytopenia and variable signs of organ damage due to platelet thrombi in the microcirculation. in children, infections with shigella dysenteriae type 1 or particular strains of escherichia coli are the most common cause of tma; in adults, a variety of underlying causes have been identified, such as bacterial and viral infections, bone marrow and organ transplantation, pregnan ...	2001	11444722
inverse expression of p(k) and luke blood group antigens on human rbcs.	luke (lke) is a high-frequency rbc antigen, related to the p blood group system. a lke-negative phenotype is found in 1 to 2 percent of donors and may be associated with increased p(k). because p(k) and similar glycolipids are receptors for shiga toxin on cell membranes, a lke-negative phenotype could have implications for infections by shigella dysenteriae and enterohemorrhagic escherichia coli.	2001	11452158
dysentery in patients infected with human immunodeficiency virus in zimbabwe: an emerging role for schistosoma mansoni and escherichia coli o157?	information on bloody diarrhoea in hiv-positives is scarce. a prospective study was therefore performed, in zimbabwe, to determine and compare the pathogens associated with bloody diarrhoea in 25 antiretroviral-naïve hiv-infected patients and 15 non-hiv-infected patients. stool cultures and colonic biopsies were performed. shigella was isolated from 18 (45%) of the subjects, schistosoma mansoni from eight (16%), escherichia coli h7:o157 from three (8%) and campylobacter jejunii from two (5%). th ...	2001	11487372
correlation between congo red binding and contact haemolysin production in shigella species.	haemolytic strains of shigella dysenteriae type 1, shigella flexneri, shigella boydii and shigella sonnei cultured on congo red agar produced pigmented colonies (pcr+) whereas nonhaemolytic strains produced white colonies and did not bind congo red (pcr-). s. flexneri-1 haemolysin negative mutant (lacking plasmid) of haemolysin positive prototroph also did not bind congo red and produced nonpigmented colonies. among the twelve strains of shigella included in this study, the characteristics of co ...	2001	11491522
shiga toxins.	shiga toxin and shiga-like toxins belong to the group of protein toxins which have a moiety that binds to the cell surface and another enzymatically active moiety that after entry into the cytosol inhibits protein synthesis enzymatically. the toxins can also cause apoptosis by mechanisms that may be different from the effect on the protein synthesis machinery. shigella dysenteriae, some strains of escherichia coli as well as other bacteria can secrete such toxins which cause serious complication ...	2001	11595626
sequence analysis of four shigella boydii o-antigen loci: implication for escherichia coli and shigella relationships.	shigella strains are in reality clones of escherichia coli and are believed to have emerged relatively recently (g. m. pupo, r. lan, and p. r. reeves, proc. natl. acad. sci. usa 97:10567-10572, 2000). there are 33 o-antigen forms in these shigella clones, of which 12 are identical to o antigens of other e. coli strains. we sequenced o-antigen gene clusters from shigella boydii serotypes 4, 5, 6, and 9 and also studied the o53- and o79-antigen gene clusters of e. coli, encoding o antigens identic ...	2001	11598067
gene cloning and characterization of alanine racemases from shigella dysenteriae, shigella boydii, shigella flexneri, and shigella sonnei.	alanine racemase genes (alr) from shigella dysenteriae, shigella boydii, shigella flexneri, and shigella sonnei were cloned and expressed in escherichia coli jm109. all genes encoded a polypeptide of 359 amino acids, and showed more than 99% sequence identities with each other. in particular, the s. dysenteriae alr was identical with the s. flexneri alr. differences in the amino acid sequences between the four shigella enzymes were only two residues: gly138 in s. dysenteriae and s. flexneri (glu ...	2001	11676496
shiga-toxin-converting bacteriophages.	shiga toxins (stx) comprise a family of potent cytotoxins that are involved in severe human disease. stx are mainly produced by escherichia coli isolated from human and nonhuman sources, and by shigella dysenteriae type 1. the genes encoding stx are thought to be generally encoded in the genome of lambdoid prophages (stx-converting bacteriophages; stx phages). they share a unique position in the late region of the phage genome downstream of the late promoter pr'. this location suggests that expr ...	2001	11686382
pathogenesis of infectious diarrhea.	a brief overview of some of the main features involved in normal physiological bi-directional absorption and secretion of fluid in the gut is given, including the nature and cellular location of key enzymes, ion pumps, symports, antiports and diffusion channels; the microanatomy of intestinal villous vasculature and the dynamics of villus blood flow, which together generate hypertonic zones in villus tip regions; and the production, differentiation, escalator movement (from crypt to villus tip) ...	2001	11694903
validation of salmonellosis and shigellosis diagnostic test kits at a provincial hospital in thailand.	rapid diagnosis of salmonellosis and shigellosis was performed using six different diagnostic test kits which recently have been made available commercially. they were salmo-dot, typhi-dot, shigel dot a, b, c, and d test kits for detection of salmonella spp., group d salmonellae, and groups a, b, c, and d shigella spp., respectively. the principle of all test kits is a membrane (dot) elisa using specific monoclonal antibodies to the respective pathogens as the detection reagents. the present stu ...	2001	11699718
characterization of a shiga toxin-encoding temperate bacteriophage of shigella sonnei.	a shiga toxin (stx)-encoding temperate bacteriophage of shigella sonnei strain cb7888 was investigated for its morphology, dna similarity, host range, and lysogenization in shigella and escherichia coli strains. phage 7888 formed plaques on a broad spectrum of shigella strains belonging to different species and serotypes, including stx-producing shigella dysenteriae type 1. with e. coli, only strains with rough lipopolysaccharide were sensitive to this phage. the phage integrated into the genome ...	2001	11705937
conformation of the o-specific polysaccharide of shigella dysenteriae type 1: molecular modeling shows a helical structure with efficient exposure of the antigenic determinant alpha-l-rhap-(1-->2)-alpha-d-galp.	the o-specific polysaccharide of shigella dysenteriae type 1, which has the repeating tetrasaccharide unit -->3)-alpha-l-rhap-(1-->3)-alpha-l-rhap-(1-->2)-alpha-d-galp-(1-->3)-alpha-d-glcnacp-(1--> (a-b-c-d), is a major virulence factor, and it is believed that antibodies against this polysaccharide confer protection to the host. the conformational properties of fragments of this o-antigen were explored using systematic search with a modified hsea method (glycan) and with molecular mechanics mm3 ...	2001	11744629
survival of shigella dysenteriae type 1 on fomites.	studies have shown that various objects, such as utensils, toys, and clothes, can serve as vehicles for transmission of shigella spp. shigellae can become viable but non-culturable (vbnc) when exposed to various environmental conditions as shown in earlier studies. the present study was carried out to detect vbnc shigella dysenteriae type 1 on various fomites by direct viable counting, polymerase chain reaction (pcr), and fluorescent antibody methods. s. dysenteriae type 1 was inoculated onto cl ...	2001	11761771
post-dysenteric hemolytic uremic syndrome in bulawayo, zimbabwe.	an outbreak of dysentery in zimbabwe was associated with a high mortality, especially in children who developed hemolytic uremic syndrome (hus). to examine the causes of high mortality from hus and to suggest measures that could reduce the case fatality rate, clinical and laboratory features of 91 children with dysentery were reviewed. of these, 14 developed hus; their findings were compared with age-matched controls with dysentery only. persistent alteration of consciousness after rehydration, ...	2001	11793118
testicular biopsy for infertility: a review of sixty-eight cases with a simplified histologic classification of lesions.	sixty-eight testicular biopsies (29 bilateral and 39 unilateral) done for evaluation of oligospermia and azoospermia are reviewed. a simplified classification of the histologic lesions observed is proposed. a brief discussion of the etiology and pathogenesis of some of these lesions is included.	2001	88424
ethanol, disulfiram, and pyrazole: effects on interferon production in mice.	the effects of ethanol alone or combined with pyrazole or disulfiram were studied in reference to interferon production. saline, ethanol (2 g/kg), pyrazole (2 mg/kg), or disulfiram (2 mg/kg) were injected, intraperitoneally, 3 hr after poly i:c, an interferon inducer. drugs were administered either by a single injection, or twice daily for 7 days, and the mice were sacrificed 6 hr after poly i:c. sera from mice were pooled, dialyzed, and assayed for interferon by the microplaque reduction method ...	2001	95409
runaway cordis omni-stanicor pacemaker.		2001	95306
a fair deal for ens.		2001	3633116
once daily dosage beta-blockade: antihypertensive efficacy of slow release oxprenolol as related to renin and age.	a single daily dose antihypertensive therapy with a new slow-release (sr) form of the beta-adrenoceptor blocking agent oxprenolol was as effective as a standard tid beta-blocker regimen in maintaining therapeutic effects over 24 hours. the good overall response rate (target larger than or equal to mmhg diastolic) of 67% was achieved in eight of the 11 high renin patients and 16 out of the 20 normal renin ones; the five low renin patients, who were also older, proved to be non-responsive. in term ...	2001	1071402
[syndrome of familial polycystic ovaries (stein-leventhal type): serum levels of luteinizing and follicle stimulating hormones before and after wedge resection of the ovaries].		2001	311042
efficiency of utilization of a computed tomography scanner.	efficient utilization of diagnostically effective but expensive computed tomography (ct) brain scanners requires understanding of time factors influencing patient throughput. in a study at ucla medical center using an emi mark i brain scanner, the average number of patients studied was 16.3 per 15.5 hr workday, for an average of 52.7 min per patient. of the patients, 51.5% were inpatients at ucla, 45% received intravenous iodinated constrast infusion, and 33% had studies showing significant abno ...	2001	97991
contribution of computed tomography to the treatment of lymphomas.	the effectiveness of computed body tomography (ct) in the workup, treatment planning, and follow-up of 38 patients with hodgkin's disease and 59 with non-hodgkin's lymphoma was analyzed. ct scanning can frequently define lymphoma in the retroperitoneum, and occasionally in mesenteric lymph nodes, spleen, and liver. these data are useful for staging, for radiotherapy treatment planning, and in monitoring response to radiotherapy or chemotherapy. ct was found to be particularly useful in patients ...	2001	97988
intercellular contacts in primate cerebral arteries: acute effects of subarachnoid injection of artificial cerebrospinal fluids, serotonin, and blood.		2001	97923
prevention through mental health.		2001	98494
regional differences in tumor growth: studies of the vascular system.		2001	98454
psychological troubles at the menopause.		2001	87786
the effect of heat shock on gene expression in drosophila melanogaster.		2001	98271
performance of blood-glucose meters.		2001	87872
[new data on glycosaminoglycans and proteoglycans].	the most important investigations on glycose aminoglycans and proteoglycans, carried out within the recent 5-7 years, are reviewed. data on primary structures repeating in glycose aminoglycans and on relationship between these biopolymers and protein components in proteoglycans are considered. newer information on conformational characteristics of glycose aminoglycans, various complexes aggregation of proteoglycans and distribution of the biopolymers in animal tissues and cells is discussed. pro ...	2001	88130
anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy.	clobazam, an anxiolytic 1,5-benzodiazepine, has been evaluated as an anticonvulsant in 2 animal models. in mice showing sound induced seizures, clobazam, 1--4 mg/kg, i.p., blocked seizure responses for 1--2 hr. in senegalese baboons papio papio showing photically induced myoclonus or seizures, clobazam, 2--12 mg/kg, i.v., totally prevented such responses for up to 6 hr. in baboons pretreated with allylglycine, 170--185 mg/kg, a similar but briefer protection was induced by clobazam. neurological ...	2001	98317
behaviour of alpha1-antitrypsin in lung cancer.		2001	98836
[palliative therapy of stenosing reflux esophagitis].		2001	93354
enzyme immunoassays revisited.		2001	90867
sodium cromoglycate (intal) in the management of chronic leg ulcers.		2001	98691
flashbacks: ventricular fibrillation part i.		2001	95318
[successful exclusively tube feeding over a period of 21 months in a cranio-cerebral injury with the apallic syndrome].		2001	99629
axoplasmic transport blockage therapy in herpes zoster ophthalmicus.	three patients with herpes zoster ophthalmicus were treated with an oral administration of colchicine and corticosteroid, while another seven were given systemic corticosteroid, vitamins, and sedatives. colchicine inhibited the formation of new skin lesions but did not suppress the already grown vesicles. the effect of colchicine was attributed to a blockage of intra-axonal dissemination by neurotrophic virus.	2001	92895
the hook sign in type 3 congenital colonic atresia.		2001	98027
infertility in a potto.		2001	97850
ataxia-telangiectasia and hepatocellular carcinoma.	ataxia-telangiectasia (at) is a multi-system disease involving the cerebellum, cutaneous blood vessels and the immune system including both cellular and humoral components. it also involves hematological, endocrine and peripheral nervous systems. this disease is often associated with abnormal liver function tests, such as, raised alkaline phosphatase and various nonspecific histological changes in the liver. high incidence of various malignancies involving lymphoreticular, gastrointestinal and m ...	2001	92892
testing meningococcal vaccines for mitogenicity and superantigenicity.	proteins with intrinsic mitogenic properties are widely represented in prokaryotes, such as in different streptococcus species (1-3), candida albicans (4), and eikenella corrodens (5). specifically, several bacterial porins of escherichia coli, shigella dysenteriae, salmonella typhimurium, fusobacterium nucleatum, and pathogenic neisseria species have been shown to induce nonspecific proliferation of lymphocytes (6-12).	2001	21336757
congenital cutis laxa and maternal d-penicillamine.		2001	88570
perinatal mortality.		2001	93220
observations on 160 patients with peripheral facial paralysis seen in private practice.		2001	98678
ddavp and cryoprecipitate in mild haemophilia.		2001	90263
[contribution of drug therapy to the efficiency in health care delivery].		2001	98692
a blood drive model for health education projects.		2001	98507
neonatal tolerance to k and d region alloantigens of h-2 complex: i-j region requirements.		2001	88101
sex ratio in glomerulonephritis.		2001	87939
hla homozygosity and neural-tube defects.		2001	87795
world survey on cardiac pacing.		2001	95323
a rapid trichrome staining procedure for the identification of tissue types.		2001	88427
correlation of histology and ultrastructure in pathology specimens.		2001	98630
editorial: microbiological safety.		2001	55659
imaging the carpal tunnel.		2001	2190578
road traffic accidents: the doctor's point of view.	one-hundred and thirty-five road traffic accident admissions (38.8% of all accidents analysed) were studied with respect to their age, sex, and distribution of injuries. it was found that the adolescent and young adult males were mostly affected. the bed utilization rate in the wards where these accident victims were admitted was found to be lower than for other wards. ways by which the services in hospitals--both specialist and general--can be organized for a more economic and efficient care of ...	2001	97953
effect, on serum lipid levels of omega-3 fatty acids, of ingesting fish-oil concentrate.		2001	92666
the lymphocyte inhibiting factor extracted from the thymus (lift): inhibition of the dna synthesis in vitro.		2000	1083769
antimicrobial potency of the leaf - stalk extract of curcuma longa (linn).	the methanolic extract of the leaf-stalk of curcuma longa linn, was tested for its minimum inhibitor concentration (mic) against gram positive-staphylococcus aureus, bacillus pumilus, bacillus subtilis, klebsiella pnemoniae, bacillus cereus, streptococcus pneumoniae, lactobacillus arabinosus and gram negative e.coli, shigella dysenteriae, shigella sonnei, shigella boydii, salmonella typhimurium, proteus mirabilis, and vibrio cholerae strains, further, the ones of inhibition produced by the crude ...	2000	22557005
a thymus-independent igg response against dextran b512 can be induced in c57bl but not in cba mice, even though both strains possess a vhdex gene.	cba and c57bl mice both possess a vhdex gene coding for antibodies against the alpha 1-6 epitope of dextran b512. after immunization with dextran, cba mice produce igm plaque-forming cells (pfc) only, which show regular cyclical fluctuations. the second pfc peak disappeared after injection of dextranase, indicating that it is antigen-dependent. the anti-dextran response in c57bl mice is characterized by only one igm peak, followed 1 day later by an igg peak that may exceed the igm response by a ...	2000	94695
reduced plasma viscosity among joggers compared with non-joggers.		2000	92344
use of the fluorochrome 4'6-diamidino-2-phenylindole in genetic and developmental studies of chloroplast dna.	use of the dna-specific fluorochrome 4'6-diamidino-2-phenylindole (dapi) makes it possible to examine in situ the structure of chloroplast dna (chdna) with the fluorescence microscope. this simplifies the study of genetic and developmental changes in chloroplast dna. three examples are presented. (a) wild-type euglena gracilis b contains several chloroplast dna nucleoids per chloroplast. a yellow mutant lacking functional chloroplasts is similar, but such nucleoids are absent in an aplastidic mu ...	2000	90051
establishment of two medical colleges in nwfp.		2000	97411
emergency arteriography in acute gastrointestinal bleeding.	emergency arteriography was carried out on 35 patients with acute gastrointestinal bleeding, in 31 of them within two hours of active bleeding (a haematemisis; a diagnostic change in central venous pressure, pulse rate, or blood pressure; or gastric aspiration of fresh blood). a definite site of bleeding was identified in 27 patients (77%)-this being a small-intestinal vascular abnormality in three--and a probable site in three. confirmation of the bleeding site was obtained in 20 out of 23 pati ...	2000	1083756
serum-myelin-basic-protein assay in diagnosis and prognosis of patients with head injury.	serum levels of myelin basic protein (m.b.p.), a nervous-system-specific protein, were measured in 157 patients after head injury and related both to the type of brain damage and to the clinical outcome assessed three months after injury. mean concentrations of m.b.p. in patients with severe intracerebral damage, with or without associated extracerebral haematoma, were significantly raised at the time of admission and remained high for two weeks after injury. in patients with extracerebral haema ...	2000	87549
levodopa boosts intellectual rating in senile dementia.		2000	101689
[importance of close observation of the patient and confirmation of the findings].		2000	97450
[shigella bacteraemia: a report of two cases observed in dakar].	shigellosis is usually a self-limiting enteric disease, rarely accompanied by extra-intestinal manifestations. in senegal, shigella bacteraemia is poorly documented. the authors report two retrospective cases of shigella dysenteriae 1 bacteraemia in an infant aged 12 months and a 32 years-old adult admitted at the infectious diseases clinic in dakar. in both cases, a fatal outcome was observed, in relation to complications: endotoxic shock in the infant, severe intestinal haemorrhage in the adul ...	2000	15779184
is serum total cholesterol outmoded?		2000	91908
failure of anti-d immunoglobulin to remove fetal red cells from maternal circulation.	a rhesus negative female was found post delivery to have circulating cells of fetal origin. the neonate was typed as d-positive. in spite of more than conventionally adequate doses of anti-d immunoglobulin given to the mother, the fetal cell count in the maternal circulation remained unchanged. further investigation showed the fetus to be a du variant and to exhibit a diminished reaction with the batch of anti-d immunoglobulin used.	2000	111422
delayed hemolytic transfusion reactions.		2000	101679
localization of murine ig-1b and ig-1a (igg 2a) allotypic determinants detected with monoclonal antibodies.		2000	94425
sensitivity of spleen-colony-forming units to chronic bleomycin.		2000	92329
interactions between polycyclic hydrocarbons and lipids in model membranes [proceedings].		2000	94797
review of laxative utilization in a skilled nursing facility.	laxatives are the most frequently prescribed drugs in long-term care facilities. of all nursing home patients, 58 percent receive laxatives--often more than one, and usually on a "prn" basis. this pattern of dosage is probably used in an effort to prevent constipation. selection of a laxative should be based on careful evaluation of the cause of constipation, with due consideration being given to differences in drug effectiveness and the incidence of side effects. a review of laxative utilizatio ...	2000	101574
some factors, influencing the sensitivity of the antibody screening the groupamatic 360 system.		2000	97759
reconstruction of the auricle.		2000	94728
a standardized estimator of the prevalence of alcoholism based on mortality data.	death rates from alcohol-related causes correlated with over-all mortality and reflected general health conditions and demographic characteristics as well as the prevalence of alcoholism.	2000	314021
[results of operative treatment of acute perforating gastroduodenal ulcer (author's transl)].	in this report of 264 operatively treated gastroduodenal perforations, differentiated, and where possible definitive, therapy is attempted. by omitting simple oversewing in favor of primary resection, bionomic operation or the combined procedure, primary lethality is reduced to one third and the late results of the survivors significantly improved. resections are indicated in benign pyloric stenosis and gastric ulcer. the bionomic operation is particularly to be preferred in young patients.	2000	101776
seizure after infusion of aminocaproic acid.		2000	101682
[cryptorchism: hormonal treatment].		2000	27065
disorders of chloriuretic hormone secretion.	experimental evidence supports the existence of a circulating substance, natriuretic hormone, which augments electrolyte excretion. because such a hormone probably acts by inhibiting chloride reabsorption in the thick, ascending limb of the loop of henle it would more accurately be called chloriuretic hormone. chloriuretic hormone must have an action which resembles that of loop diuretics such as frusemide and ethacrynic acid. an excess of chloriuretic hormone could explain all the manifestation ...	2000	86837
effect of dietary composition on fasting-induced changes in serum thyroid hormones and thyrotropin.		2000	97492
[specificity of antitumoral substances].		2000	92004
hyponatremia.		2000	97245
ige production and suppression. carrier-specific and normal t-cell interactions in suppression.		2000	91964
[conduction of disorders after total correction of fallot's tetralogy. electrocardiographic and electrophysiological study].	the conduction defects observed after total correction of fallot's tetralogy in 133 children, and their association with the long term outcome were studied with comparison of pre and postoperative electrocardiograms and, in 26 cases, his bundle recording. 23 early complete heart blocks were recorded which were nearly always transient. only 4 (3.6%) became permanent. 58 had a right bundle branch block (48.4%) and 19 a bifascicular block (15.8%). the early operative mortality (9.7%) appeared to be ...	2000	86328
serum isoamylases in diseases of the lung and control subjects of thermolabile serum amylase component.		2000	94301
antimicrobial agent resistance in bacterial isolates from patients with diarrhea and urinary tract infection in the sudan.	antimicrobial sensitivity tests were performed on four-hundred and ninety-seven bacterial isolates from sudanese patients with diarrhea or urinary tract infections. shigella dysenteriae type i and enteropathogenic escherichia coli showed high resistance rates (percentage of isolates showing antibiotic resistance) against the commonly-used antimicrobial agents: ampicillin, amoxicillin, chloramphenicol, tetracycline, cotrimoxazole, nalidixic acid, sulfonamide, and neomycin, and were completely sen ...	2000	11421374
[effect of hydroxylamine hydrochloride on lipopolysaccharide fatty acid composition in shigella dysenteriae 1].	changes in the fatty acid composition of s. dysenteriae 1 lipid a after the treatment of lipopolysaccharide (lps) with hydrosylamine hydrochloride (hh) and 4 degrees c, 37 degrees c and 56 degrees c were studied with the use of gas-liquid chromatographicmass-spectrometry. the treatment with hh led to a decrease in the toxicity of lps, but produced no changes in the content of the main fatty acid components of lipid a (lauric, myristic, oxymyristic and palmitic acids). at the same time the total ...	2000	11210628
an outbreak of dysentery in a rural district of zimbabwe: the role of personal hygiene at public gatherings.	to characterize the nature and extent of the outbreak; to determine the risk factors associated with contracting shigellosis; and to institute disease control and preventive measures.	2000	11235056
i-ceui fragment analysis of the shigella species: evidence for large-scale chromosome rearrangement in s. dysenteriae and s. flexneri.	i-ceui fragments of four shigella species were analyzed to investigate their taxonomic distance from escherichia coli and to collect substantiated evidence of their genetic relatedness because their ribosomal rna sequences and similarity values of their chromosomal dna/dna hybridization had proved their taxonomic identity. i-ceui digestion of genomic dnas yielded seven fragments in every species, indicating that all the shigella species contained seven sets of ribosome rna operons. to determine ...	2000	10612738
production of ifn-gamma and il-10 to shigella invasins by mononuclear cells from volunteers orally inoculated with a shiga toxin-deleted shigella dysenteriae type 1 strain.	volunteers were orally administered invasive, non-shiga toxin-producing shigella dysenteriae 1 to establish a challenge model to assess vaccine efficacy. in stepwise fashion, four separate groups were given 3 x 10(2), 7 x 10(3), 5 x 10(4), or 7 x 10(5) cfu. using pbmc, proliferative responses and cytokine production were measured to s. dysenteriae whole-cell preparations and to purified recombinant invasion plasmid ags (ipa) c and ipad. anti-lps and anti-ipa abs and ab-secreting cells were also ...	2000	10657678
effects of caffeic acid, chlorogenic acid and ferulic acid on growth and arylamine n-acetyltransferase activity in shigella sonnei (group d).	arylamine n-acetyltransferase (nat) activities with 2-aminofluorene (2-af) as substrates were determined in shigella sonnei (group d) collected from patients with diarrhoeal disease. the nat activity was determined using an acetyl coa recycling assay and high pressure liquid chromatography. inhibition of growth studies from s. sonnei (group d) demonstrated that caffeic acid (ca), chlorogenic acid (cga) and ferulic acid (fa) elicited a dose-dependent bactericidal effect in s. sonnei (group d) cul ...	2000	10677842
evaluation of antibacterial activity of asparagus racemosus willd. root.	different concentrations (50, 100, 150 microg/ml) of the methanol extract of the roots of asparagus racemosus willd. showed considerable in vitro antibacterial efficacy against escherichia coli, shigella dysenteriae, shigella sonnei, shigella flexneri, vibrio cholerae, salmonella typhi, salmonella typhimurium, pseudomonas putida, bacillus subtilis and staphylococcus aureus. the effects produced by the methanol extract were compared with chloramphenicol.	2000	10685109
blocking bacterial enterotoxins.		2000	10700222
a new biological agent for treatment of shiga toxigenic escherichia coli infections and dysentery in humans.	gastrointestinal disease caused by shiga toxin-producing bacteria (such as escherichia coli o157:h7 and shigella dysenteriae) is often complicated by life-threatening toxin-induced systemic sequelae, including hemolytic-uremic syndrome. such infections can now be diagnosed very early in the course of the disease, but at present no effective therapeutic intervention is possible. here, we constructed a recombinant bacterium that displayed a shiga toxin receptor mimic on its surface, and it adsorbe ...	2000	10700227
nmr spectroscopy, molecular dynamics, and conformation of a synthetic octasaccharide fragment of the o-specific polysaccharide of shigella dysenteriae type 1.	a synthetic octasaccharide fragment (2) of the o-specific polysaccharide (1) of shigella dysenteriae type 1 has been studied as its methyl glycoside by one- and two-dimensional homo- and heteronuclear nmr spectroscopy. complete 1h and 13c nmr assignments have been generated, and the 13c spin-lattice relaxation times have been measured for the octasaccharide 2. a congener (6) of this octasaccharide containing one d-galactose residue with a specific 13c label at c-1 has been synthesized and used t ...	2000	10723612
antimicrobial resistance trends in shigella serogroups isolated in israel, 1990-1995.	from a total of 31319 shigella strains isolated in israel between 1990 and 1996, 17574 were sent to the national shigella reference center for typing. of these, 15287 were identified as shigella sonnei, 1833 as shigella flexneri, 327 as shigella boydii and 127 as shigella dysenteriae. in all, 4395 strains were tested for sensitivity to ampicillin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, nalidixic acid and ofloxacin. all strains tested were sensitive to ofloxacin, and only t ...	2000	10746496
induction of mrna for tumor necrosis factor-alpha and interleukin-1 beta in mice brain, spleen and liver in an animal model of shigella-related seizures.	the pathogenesis of neurological symptoms, the most common extraintestinal complication of childhood shigellosis, is unclear. to elucidate the mechanisms involved, we developed an animal model and demonstrated that tnf alpha and il-1 beta play a role.	2000	10804924