Publications

increased synthesis of p-aminobenzoic acid associated with the development of sulfonamide resistance in staphylococcus aureus.	sulfonamide-resistant strains of staphylococcus aureus produce greater amounts of p-aminobenzoic acid than do their parent strains. this synthesis occurs both in the absence and in the presence of sulfonamides. the quantity of p-aminobenzoic acid synthesized by resistant strains appears sufficient to account for their resistance to sulfonamide drugs. on the basis of this evidence, it is suggested that the development of ability to synthesize p-aminobenzoic acid in excess of the normal metabolic ...	1943	17744237
the local effect of sulfanilamide, sulfathiazole and sulfadiazine upon hemolytic staphylococcus aureus infections of the pleural cavity.		1943	17858210
use and abuse of staphylococcus aureus as a test organism.		1942	18015602
studies on the antibacterial action of the sulfonamide drugs : ii. the possible relation of drug activity to substances other thanp-aminobenzoic acid.	1. in cultures of staphylococus aureus in a synthetic medium nicotinamide and cozymase were shown to block the bacteriostatic action of chemically unrelated sulfonamide drugs as well as the chemically related compound sulfapyridine. the antibacterial properties of organic dyes totally unrelated to the sulfonamide compounds (methylene blue and thionine) were also nullified by the addition of cozymase to the culture medium. 2. the antagonistic action of the pyridine-containing coenzyme, cozymase, ...	1942	19871191
the action of sulfonamides on the respiration of bacteria and yeast : inhibition of bacterial and yeast carboxylases by sulfonamide drugs structurally related to cocarboxylase.	the inhibiting effects of sulfonamide drugs and their derivatives on the anaerobic decarboxylation of pyruvic acid by staphylococcus aureus, escherichia coli, baker's and brewer's yeast, and a carboxylase preparation from brewer's yeast have been investigated. these drugs are: sulfanilamide, sulfapyridine, sulfadiazine, sulfamethyldiazine, sulfathiazole, sulfamethylthiazole, sulfanilamido-5-ethyl-4-thiazolone, 2-aminopyrimidine, 2-aminothiazole, and 2-aminopyridine. the sulfathiazole ring appear ...	1942	19873315
cyanide-sensitive bacterial respiratory systems different from the usual cytochrome-cytochrome oxidase system.	aerobic respiration of streptococcus pyogenes and pneumococcus type 1 are strongly inhibited by kcn, nan(3), and na(2)s. the anaerobic glycolysis of glucose by pneumococcus is also inhibited by kcn and nan(3). streptococcus pyogenes, e. coli, pneumococcus type 1, b. subtilis, b. proteus, and staphylococcus aureus did not catalyze the oxygen uptake by p-phenylenediamine in the presence of added cytochrome c or in its absence. yeast cells, b. subtilis, and b. pyocyaneus oxidized p-phenylenediamine ...	1942	19873323
staphylococcus aureus in the milk of nursing mothers and the alimentary canal of their infants: a report to the medical research council.		1942	20475647
the effect of inorganic salts on the production of small colony variants by staphylococcus aureus.		1942	16560541
classification of 110 strains of staphylococcus aureus.		1942	16560597
the nutrition of staphylococcus aureus: the influence of biotin, bios ii(b) and vitamin h on the growth of several strains.		1941	16560395
staphylococcus aureus septicaemia with recovery, treated with m & b 693.		1940	19992278
staphylococcus aureus septicæmia with recovery, treated with m & b 693.		1940	20916675
staphylococcus aureus infection of the long bones in the newly born.		1940	21032163
the relationship of sulfapyridine, nicotinic acid, and coenzymes to the growth of staphylococcus aureus.	our studies indicate that sulfapyridine modifies the normal metabolism of a bacterium. coenzymes inhibit the effect of sulfapyridine on the growth of staphylococcus in knight's medium. nicotinic acid does not interfere with the action of sulfapyridine under the same conditions. the possible relation of sulfapyridine, nicotinic acid, and coenzymes in relation to bacterial growth is discussed.	1940	19871010
illness due to commercially prepared egg and olive sandwiches contaminated by a probable carrier of hemolytic staphylococcus aureus.		1940	18015340
staphylococcus aureus meningitis: report of case: treatment with sulfanilamide-recovery.		1939	18745384
the nature of the catalase reaction in the residue of staphylococcus aureus lysed by bacteriophage.		1939	16560279
aneurin (vitamin b(1)) and pyruvate metabolism by staphylococcus aureus.		1938	16746631
production of experimental osteomyelitis in rabbits by intravenous injection of staphylococcus aureus.	1. the conditions under which a certain strain of staphylococcus (oh 172) causes in rabbits the development of bone inflammation have been described. 2. the virulence of the strain for rabbits was markedly raised by passage through this animal species, and especially after the culture had been recovered from a bone abscess. 3. the results indicate that it is possible to produce consistently inflammation of the bones of rabbits by the mere intravenous injection of a suitable strain of staphylococ ...	1938	19870782
the germicidal power of some alcohols for bacterium typhosum and staphylococcus aureus, and its relation to surface tension.		1938	21433806
the nutrition of staphylococcus aureus; nicotinic acid and vitamin b(1).		1937	16746392
the nutrition of staphylococcus aureus. the activities of nicotinamide, aneurin (vitamin b(1)) and related compounds.		1937	16746423
spectrographic identification of nicotinic acid in staphylococcus aureus growth factor concentrates.		1937	16746458
the nutrition of staphylococcus aureus. necessity for uracil in anaerobic growth.		1936	16746278
studies on small colony variants of staphylococcus aureus.		1935	16559804
the effect of staphylococcus aureus toxin on the kidney.	1. the hemolytic staphylococcus aureus elaborates a toxin in vitro that when injected intravenously produces lesions in the kidneys of rabbits and cats. 2. the toxin injures primarily the blood vessels of the kidney.	1935	19870338
outbreak of food poisoning, probably due to staphylococcus aureus.		1935	18014272
a study on bacterial proteins with special consideration of gonococcus and meningococcus.	methods of preparation and certain properties of the "nucleoproteins" of the following organisms are described: gonococcus, meningococcus, micrococcus catarrhalis, r pneumococcus, streptococcus hemolyticus, staphylococcus aureus. no essential differences between the nucleoproteins and the intact cells of gonococcus and meningococcus were observed in their ability to engender immune substances (precipitins), to induce bacterial allergy in rabbits, or to elicit cutaneous reactions (of the delayed ...	1934	19870231
the carbohydrates of gonococcus and meningococcus : i. the alcohol-precipitable fraction.	the alcohol-insoluble polysaccharides of gonococcus and meningococcus were found to contain 4.2 and 3.7 per cent nitrogen respectively, to be protein-free by chemical test, to reduce fehiing-benedict solution only after hydrolysis. they were non-toxic for rabbits and mice, and failed to engender antibodies (precipitins) in rabbits. they produced no cutaneous reactions in normal, snuffle-free rabbits, but caused typical allergic reactions of the delayed type in rabbits rendered hypersensitive to ...	1934	19870232
results of irradiating staphylococcus aureus bacteriophage with monochromatic ultraviolet light.	the incident energies required to kill staphylococcus aureus or to inactivate its homologous bacteriophage have been measured at the various wave-lengths of the quartz mercury vapor arc between 238 and 302 mmicro and found to run strictly parallel, the readings for the s. aureus phage being obtained at a uniformly higher energy level. this difference in levels is of less significance than the striking similarity in the shapes of the energy curves, which indicate that in both instances the same o ...	1934	19870293
dissociation of staphylococcus aureus.		1934	16559720
evaluation of some factors influencing the phenol resistance of staphylococcus aureus.		1934	16559752
oxidation-reduction potentials of cultures of staphylococcus aureus.		1933	16559630
studies on inflammation : ix. a factor in the mechanism of invasiveness by pyogenic bacteria.	trypan blue injected into an area of cutaneous inflammation induced by staphylococcus aureus failed to drain readily to the tributary lymphatics when the dye was injected as early as 1 hour after the inoculation of the microorganisms. trypan blue introduced into an area of cutaneous inflammation induced by pneumococcus type i was retained in situ when the dye was injected about 6 or more hours after the inoculation of the bacteria. when an area of cutaneous inflammation was induced by the inocul ...	1933	19870174
a case of staphylococcus aureus pyaemia with osteomyelitis treated with gentian violet.		1933	20319015
protection of adrenalectomized animals against bacterial intoxication by an extract of the adrenal cortex.	1. the resistance of adrenal-deficient rats to bacterial intoxication has been significantly increased by an extract of the adrenal cortex. 2. this is shown both for acute intoxication with killed bacillus typhosus and for chronic intoxication with killed staphylococcus aureus. 3. during the height of the bacterial intoxication relatively large amounts of the cortical hormone are apparently required to maintain the animals. 4. it is considered probable that a human pyogenic infection imposes a s ...	1932	19869979
further experiences with non-specific local cutaneous immunity to staphylococcus aureus : local non-specific protection.	1. many substances besides the specific broth filtrates of besredka can be utilized as topical applications to protect guinea pigs from the effects of massive doses of staphylococcus given subcutaneously. (plain broth, peptone 10 per cent, peptone 1 per cent, liebig's meat extract, mustard plaster and normal horse serum.) 2. where such protection occurs, no matter what the stimulus is, the local skin reaction microscopically is the same as that previously described for broth compresses. 3. many ...	1931	19869849
pyocyanine, an accessory respiratory enzyme.	pyocyanine, the blue pigment of b. pyocyaneus, can increase the respiration of living cells to a great degree (maximum observed increase 24-fold). the reversibility of its oxidation and reduction is responsible for this. the effect is non-species-specific and has been observed in varying degrees with b. pyocyaneus, staphylococcus aureus, pneumococcus type iii, and the red blood corpuscles of rabbits. the effect of pyocyanine is dependent on the presence of another respiratory ferment sensitive t ...	1931	19869911
differentiation between certain toxic properties of filtrates of hemolytic staphylococcus aureus.	1. sterile filtrates from certain hemotoxic strains of staphylococcus aureus have several toxic properties, of which the most important are the hemotoxic, the necrotoxic, the leucocidic and the property of killing rapidly. 2. the necrotoxic action appears to be caused by a constituent in the filtrates different from either the hemotoxic or the leucocidic one.	1931	19869919
the examination of the tissues and some observations of the blood platelets of rabbits at intervals of five minutes, and later, after intravenous inoculations of staphylococcus aureus and indian ink.		1931	20475091
the effect of cathode rays upon certain bacteria.	1. for the two motile bacilli, b. coli and b. aertryke, the absorption of a single 155 k.v. electron is sufficient to cause death. furthermore, all, or nearly all, the electrons absorbed are lethal. the same is undoubtedly true of staphylococcus aureus. in addition to providing a quantitative picture of the interaction of bacteria and cathode rays, these results suggest that radiation of the energy content used in our experiments is not suitable for altering the inheritable characteristics of ba ...	1930	19869738
the germicidal action of hydroxy soaps.	1. the alpha-hydroxy soaps exhibit a high germicidal action toward certain organisms. as with other soaps, the germicidal action increases with molecular weight to a maximum, then diminishes. the ph effects the germicidal action as it does other soaps. 2. certain alpha-hydroxy soaps give two distinct germicidal zones with staphylococcus aureus. 3. the effect of the hydroxyl group in saturated soaps is to increase selective germicidal action; the effect of the hydroxyl group in an unsaturated soa ...	1929	19869624
a study of the effects of long wave x-rays on the staphylococcus aureus and on the microsporum audouini.		1929	20317327
the role of clasmatocytes and connective tissue cells in non-specific local cutaneous immunity to staphylococcus.	1. plain broth is just as effective as specific broth filtrate if used as a skin compress for the protection of guinea pigs against a subcutaneous injection of staphylococcus aureus. 2. plain broth compresses applied for 48 hours previous to bacterial injection sometimes prevent the death of the animal and practically always alter the inflammatory reactions. 3. this protection is not specific and is localized to the area "compressed." 4. the protection lasts at least 24 hours after removal of th ...	1928	19869436
local immunity in experimental erysipelas.	the experiments recorded show that the skin involved in the zone of inflammation produced by the endodermal injection of virulent living erysipelas streptococci into rabbits becomes, after the lesion has healed, partially but not completely resistant to subsequent infection with the homologous organism. in the majority of experiments the lesion resulting from the first endodermal injection spread downward, i.e., ventrally, to the site of needle puncture forming an oval or elongated inflammatory ...	1927	19869261
physical, chemical, and biological studies on the virus of vesicular stomatitis of horses : comparison with the virus of foot-and-mouth disease.	a taxonomic study of the virus of vesicular stomatitis is presented along with evidence additional to that already reported(1) to show the similarity of this virus to that of foot-and-mouth disease. the connection of the two is discussed and the deduction drawn that their generic relationship is close. on the contrary, the differences between these two viruses and the herpetic are sufficiently marked to indicate a lack of generic connection among the three. the results of a comparative study on ...	1927	19869312
studies in the common cold : i. observations of the normal bacterial flora of nose and throat with variations occurring during colds.	1. the normal bacterial flora of the nose and throat of thirteen individuals has been studied over periods ranging from 5 to 9 months. 2. observations have been made of qualitative and quantitative changes in the flora occurring in the course of colds and of throat infections appearing in the group. 3. the normal basic nasal flora includes staphylococcus albus, diphtheroids, and for certain individuals staphylococcus aureus and citreus. occasional transient bacteria are gram-negative cocci and n ...	1926	19869133
local immunization of rabbits to cutaneous infection with staphylococcus aureus.	1. bacterial filtrates were prepared by the methods described by besredka, but these never developed any specific growth-inhibiting factors. 2. such filtrates produced a strictly local immunity of the areas of the skin infiltrated but such protection was never greater than that produced with the broth from which they were prepared. this immunity was manifest within 8 hours and persisted at least 15 days. 3. transcutaneous treatment by moist dressings soaked in either filtrate or broth were entir ...	1925	19869066
the resistance to phenol of staphylococcus aureus.		1925	18011549
the occurrence of peroxide in cultures of pneumococcus.	1. conditions which favor the formation and accumulation of peroxide in broth cultures of pneumococcus are free access of air, and the absence of catalase, peroxidase, and other catalysts capable of decomposing this compound. under these favorable conditions peroxide becomes demonstrable in the culture fluid during the logarithmic phase of growth and persists for a period of at least 6 to 12 days. 2. in the absence of these favorable conditions the formation of peroxide is inhibited. in a cultur ...	1924	19868843
the production of an exotoxin by certain strains of staphylococcus aureus.	1. the sterile berkefeld filtrates of broth cultures of certain strains of staphylococcus aureus have a selective poisonous action for the skin of rabbits. 2. the poison is thermolabile, being completely destroyed when heated to 55 degrees c for 1 hour. 3. the poison when injected intradermally into rabbits stimulates the production of antitoxin. we therefore conclude that the poison is a soluble toxin.	1924	19868957
studies on the pneumococcus : ii. dissolution of pneumococci at varying hydrogen ion concentrations. effect of temperature, previous killing of the organisms, and fresh human serum on the phenomenon. behavior of other organisms.	suspensions of living pneumococci in approximately isotonic standard solutions and in approximately isotonic bouillon with ph varying from about 4.0 to 8.0 after incubation show dissolution of organisms in those solutions having a ph higher than about 5.0. dissolution is most marked at a critical range of about ph 5.0 to 7.0. some dissolution also takes place toward the more alkaline end of the scale. no dissolution occurs at the most acid end of the scale. dissolution in the standard solutions ...	1922	19868639
the organotropic, bacteriotropic, and leucocytotropic actions of certain organic chemicals.	we are dealing, as the results show, with groups of chemicals, all of which, whether bacteriotropic or not, greatly inhibit the engulfing of staphylococcus aureus by leucocytes. not a sufficiently large number of experiments was performed in attempt to cure experimental staphylococcus infections to warrant any condusion in regard to possible therapeutic activity against this organism. how-ever, as will appear in another paper, the only group out of the seven which definitely possessed an in vivo ...	1922	19868662
the hydrogen ion concentration of joint exudates in rheumatic fever and other forms of arthritis.	1. the hydrogen ion concentration of joint exudates aspirated from patients ill with acute rheumatic fever, arthritis of undetermined origin, and bacterial arthritis was determined. the hydrogen ion concentrations of the joint exudates from patients with acute rheumatic fever approximated the normal reaction of blood, varying from ph 7.27 to 7.42. exudates from patients with arthritis of undetermined origin varied in ph from 7.33 to 7.47. the ph of a joint effusion occurring in a patient with my ...	1922	19868683
experimental studies on the etiology of typhus fever : i. concurrent infections during the course of experimental typhus fever in guinea pigs.	the work reported in this paper relates to the bacteria which can be cultivated from the blood and spleen of guinea pigs at different stages of infection with the virus of typhus fever. the studies show that during the period of incubation and before the onset of fever no ordinary bacteria appear in the cultures, while on the 1st day of the febrile reaction different bacteria were found in 6 of 26 guinea pigs cultured; on the 2nd day, in 10 of 16; on the 3rd day, in 3 of 4; and on the 4th day in ...	1921	19868575
a study of the antiseptic properties of certain organic compounds.	this study of the inhibitive effect of aniline and some of its derivatives and of the triphenylmethane dyes on certain bacteria warrants the following tentative conclusions: 1. the composition and reaction of the medium exert a marked influence on the behavior of the antiseptic. the higher the concentration of organic nitrogenous compounds (peptone) in the medium, the lower is the effective concentration of the dye. the reaction of the medium modifies the specific action of the antiseptic, owing ...	1918	19868219
studies on antiblastic immunity.	antipneumococcus serum under certain conditions apparently inhibits or retards the metabolic activities of the homologous pneumococcus. antipneumococcus serum exhausted of its agglutinin content possesses no inhibitory properties. the degree of inhibitory action of antipneumococcus serum parallels its agglutinating power. no evidence has been found to indicate that the inhibition of the metabolic activities of the pneumococcus by antipneumococcus serum is due to a specific antienzymotic property ...	1917	19868167
the production of kidney lesions with staphylococcus aureus toxins.		1917	19972339
study i: studies on staphylococcus pyogenes aureus, albus and citreus, and on micrococcus tetragenus and m. catarrhalis.		1917	19972342
the fate of micrococcus aureus introduced into the blood stream of dogs.		1917	19972349
study xiii: the relationship between the cutaneous reaction, serum agglutination tests and bacteriological examination of the sputum and nasal secretions in determining the part staphylococcus pyogenes aureus and albus may play in the cause of bronchial asthma.		1917	19972369
the fate of staphylococcus pyogenes aureus introduced intravenously into actively immunized dogs; and of killed bacteria introduced intravenously into normal dogs.		1917	19972391
the reactions between bacteria and animal tissues under conditions of artificial cultivation : iii. the action of bacterial vaccines on tissue cultures in vitro.	these results seem to indicate that many bacteria may be utilized by tissue cells as food for growth or may contain a substance or substances stimulating cell growth or multiplication. this substance is stable and is not destroyed by heating to 100 degrees c. or by long standing. with micrococcus aureus this action is often neutralized or overcome by a substance inhibitory to growth. the nature of these substances has not yet been determined, though several attempts along this line were made by ...	1916	19867986
further observations on the agglutination of bacteria in vivo.	1. pneumococci, dysentery bacilli of the shiga type, and bacillus mucosus capsulatus are agglutinated immediately when injected into the circulation of actively immunized rabbits. 2. staphylococcus aureus and albus, colon bacilli, meningococci, gonococci, and non-virulent pneumococci agglutinate in the circulation of normal rabbits. 3. bouillon cultures of bacillus avisepticus are highly toxic for both rabbits and dogs. the fresh sera of these animals have no bactericidal action upon the bacteri ...	1916	19868025
the comparative resistance of bacteria and human tissue cells to certain common antiseptics.	the comparative resistance of bacteria and human tissue cells to antiseptics and other chemicals may be easily tested by tissue cultures under conditions which approximate those found in the living body. a comparative study shows that while human cells (connective tissue and wandering cells) are highly resistant to many antiseptics, they are in general more easily killed than bacteria (staphylococcus aureus). of the antiseptics tested, which include mercuric chloride, iodine, potassium mercuric ...	1916	19868066
the reactions between bacteria and animal tissues under conditions of artificial cultivation.	this report gives an outline of the results of observations on over 1,100 tissue cultures made during the fall, winter, and spring of 1913 to 1914. the work has been resumed in the fall of 1914 and will be continued along the same and allied lines, confirming the above results with other strains of the same organisms and with other bacteria and bacterial products. tests should be made with tissue and plasma from other animals, and the known pathogenicity of the organism for the animal and tissue ...	1915	19867854
chronic dermatitis of the pinna due to infection by staphylococcus aureus, under treatment by vaccine.		1911	19975373
an experimental study of opsonic immunity to staphylococcus aureus.	1. the administration of staphylococcus aureus, killed by heat (vaccine), produces a high degree of opsonic immunity in rabbits. 2. such increase of opsonin affords protection against living virulent staphylococcus in direct proportion to the amount of opsonins present in the serum and complete recovery may follow subsequent inoculation, if the opsonic power be high. 3. frequent administration of vaccines may produce a diminution of the opsonic power of the serum. 4. immune opsonins are most act ...	1910	19867314
on a uterine fibroid in the state of red degeneration containing staphylococcus pyogenes aureus.		1909	19973837
calcification of the breast following a typhoid abscess.	1. in a patient with typhoid fever, who had taken, during eleven days, 132 grammes of lactate of calcium by the mouth, as well as 5 grammes of chloride of calcium subcutaneously, there developed, eleven days after the subcutaneous infusion, a large abscess of the breast from which bacillus typhosus and staphylococcus aureus were obtained on culture. the abscess was opened and the wound packed with iodoform gauze. eleven days later a deposit of calcium appeared in the granulation tissue bordering ...	1907	19867070
vi. a case of acute osteomyelitis of the femur, with general systemic staphylococcus aureus infection, terminating in recovery.		1900	17860813
the influence of acute alcoholism on the normal vital resistance of rabbits to infection.	the deductions that may be drawn from the results of these experiments are as follows: that the normal vital resistance of rabbits to infection by streptococcus pyogenes (erysipelatos) is markedly diminished through the influence of alcohol when given daily to the stage of acute intoxication. that a similar, though by no means so conspicuous, diminution of resistance to infection and intoxication by the bacillus coli communis also occurs in rabbits subjected to the same influences. and that, whi ...	1896	19866807
a study of the charges produced in the kidneys by the toxins of the staphylococcus pyogenes aureus.		1896	19866816
preliminary description of the staphylococcus aureus liquefacians.		1896	19971094
discovery and characterization of two nimrod superfamily members in anopheles gambiae.	anti-bacterial proteins in mosquitoes are known to play an important modulatory role on immune responses to infections with human pathogens including malaria parasites. in this study we characterized two members of the anopheles gambiae nimrod superfamily, namely agnimb2 and ageater. we confirm that current annotation of the an. gambiae genome incorrectly identifies agnimb2 and ageater as a single gene, agap009762. through in silico and experimental approaches, it has been shown that agnimb2 is ...	0	24428830
in vitro screening antibacterial activity of bidens pilosa linné and annona crassiflora mart. against oxacillin resistant staphylococcus aureus (orsa) from the aerial environment at the dental clinic.	currently multiresistant staphylococcus aureus is one common cause of infections with high rates of morbidity and mortality worldwide, which directs scientific endeavors in search for novel antimicrobials. in this study, nine extracts from bidens pilosa (root, stem, flower and leaves) and annona crassiflora (rind fruit, stem, leaves, seed and pulp) were obtained with ethanol: water (7:3, v/v) and their in vitro antibacterial activity evaluated through both the agar diffusion and broth microdilut ...	0	25076435
antioxidant, antibacterial and cytotoxic effects of the phytochemicals of whole leucas aspera extract.	to investigate the antioxidant, antibacterial and cytotoxic activity of whole leucas aspera (labiatae) (l. aspera) alcoholic extract.	0	23620850
molecular cloning and characterization of a new c-type lysozyme gene from yak mammary tissue.	milk lysozyme is the ubiquitous enzyme in milk of mammals. in this study, the cdna sequence of a new chicken-type (c-type) milk lysozyme gene (yml), was cloned from yak mammary gland tissue. a 444 bp open reading frames, which encodes 148 amino acids (16.54 kda) with a signal peptide of 18 amino acids, was sequenced. further analysis indicated that the nucleic acid and amino acid sequences identities between yak and cow milk lysozyme were 89.04% and 80.41%, respectively. recombinant yak milk lys ...	0	26580446
hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates.	multidrug resistant (mdr) pathogen infections are serious threats to hospitalized patients because of the limited therapeutic options. a novel group of antibiotic candidates, antimicrobial peptides (amps), have recently shown powerful activities against both gram-negative and gram-positive bacteria. unfortunately, the viability of using these amps in clinical settings remains to be seen, since most still need to be evaluated prior to clinical trials and not all of amps are potent against mdr cli ...	0	25730460
depletion of t cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.	the enzyme lysostaphin possesses potent anti-staphylococcal activity and represents a promising antibacterial drug candidate; however, its immunogenicity poses a barrier to clinical translation. here, structure-based biomolecular design enabled widespread depletion of lysostaphin drb1(∗)0401 restricted t cell epitopes, and resulting deimmunized variants exhibited striking reductions in anti-drug antibody responses upon administration to humanized hla-transgenic mice. this reduced immunogenicity ...	0	26000749
immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (mog)10-60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model.	current therapies for multiple sclerosis (ms), a chronic autoimmune neuroinflammatory disease, mostly target general cell populations or immune molecules, which may lead to a compromised immune system. a more directed strategy would be to re-enforce tolerance of the autoaggressive t cells that drive tissue inflammation and injury. in this study, we have investigated whether the course of experimental autoimmune encephalomyelitis (eae) in mice and marmosets can be altered by a potent tolerizing f ...	0	25393803
preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radio- protective mn2+-peptide complex from deinococcus.	although pathogen inactivation by γ-radiation is an attractive approach for whole-organism vaccine development, radiation doses required to ensure sterility also destroy immunogenic protein epitopes needed to mount protective immune responses. we demonstrate the use of a reconstituted manganous peptide complex from the radiation-resistant bacterium deinococcus radiodurans to protect protein epitopes from radiation-induced damage and uncouple it from genome damage and organism killing. the mn(2+) ...	0	22817993
synthesis and biological evaluation of formazan derivatives.	the formazan derivatives (fm1-fm5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. the structures of the synthesized compounds were then elucidated using uv, ir, (1)h nmr and mass spectral data. the synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. all the compounds showed remarkable antibacterial activity at 250 μg/ml, but fm4 and fm3 did not show any inhibition on staphylococc ...	0	22247879