Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| safety, immunogenicity and efficacy after switching from reference infliximab to biosimilar sb2 compared with continuing reference infliximab and sb2 in patients with rheumatoid arthritis: results of a randomised, double-blind, phase iii transition study. | efficacy, safety and immunogenicity results from the phase iii study of sb2, a biosimilar of reference infliximab (inf), were previously reported through 54 weeks. this transition period compared results in patients with rheumatoid arthritis (ra) who switched from inf to sb2 with those in patients who maintained treatment with inf or sb2. | 2018 | 29042358 |
| biochemical and biophysical characterization of a mycoredoxin protein glutaredoxin a1 from corynebacterium pseudotuberculosis. | glutaredoxin a1 from corynebacterium pseudotuberculosis was shown to be a mycoredoxin protein. in this study, we established a process to overexpress and purify glutaredoxin a1. the aim of this study was the investigation of the glutaredoxin a1 from c. pseudotuberculosis behavior under different redox environments and the identification of lead molecules, which can be used for specific inhibitor development for this protein family. a quantitative assay was performed measuring the rate of insulin ... | 2018 | 29042280 |
| acetoclastic methanosaeta are dominant methanogens in organic-rich antarctic marine sediments. | despite accounting for the majority of sedimentary methane, the physiology and relative abundance of subsurface methanogens remain poorly understood. we combined intact polar lipid and metagenome techniques to better constrain the presence and functions of methanogens within the highly reducing, organic-rich sediments of antarctica's adélie basin. the assembly of metagenomic sequence data identified phylogenic and functional marker genes of methanogens and generated the first methanosaeta sp. ge ... | 2018 | 29039843 |
| two new species and seven new records of horse fly (diptera: tabanidae) from malaysia, including a description of new species and modified keys. | horse flies (diptera: tabanidae) are of medical and veterinary importance, as their blood-sucking feeding habit enables them to transmit several disease-causing agents. in malaysia, the family tabanidae consists of 120 species belonging to eight genera. the current study describes two new species (chrysops idlani sp. nov. and tabanus ekor sp. nov.) and presents new records for seven species: tabanus fontinalisschuurmans stekhoven, 1926; tabanus fuscifronsschuurmans stekhoven, 1926, tabanus latif ... | 2018 | 29040652 |
| description of trichophoromyia velezbernali, a new sand fly species (diptera: psychodidae: phlebotominae) from colombian amazonia. | a new species of phlebotomine sand fly, trichophoromyia velezbernali sp. n. posada-lópez, galvis & galati, from colombian amazonia is described with illustrations and images of male and female adults. | 2018 | 29040643 |
| description of evandromyia piperiformis sp. nov. (diptera: psychodidae). | brazil presents great sand fly species diversity, with new species constantly being described, as new areas are surveyed to monitor sand flies. in captures undertaken in porto velho, rondônia state-brazil, a new species, evandromyia (aldamyia) piperiformissp. nov. (godoy, cunha & galati 2017), was found and is here described. both sexes of this new species may be distinguished from those of the aldamyia subgenus through morphometric and morphological characters. further, we present an identifica ... | 2018 | 29040616 |
| magnitude of muscle strength and mass adaptations between high-load resistance training versus low-load resistance training associated with blood-flow restriction: a systematic review and meta-analysis. | low-load resistance training (< 50% of one-repetition maximum [1rm]) associated with blood-flow restriction (bfr-rt) has been thought to promote increases in muscle strength and mass. however, it remains unclear if the magnitude of these adaptations is similar to conventional high-load resistance training (> 65% 1rm; hl-rt). | 2018 | 29043659 |
| an extended twin-pedigree study of neuroticism in the netherlands twin register. | for the participants in the netherlands twin register (ntr) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. a total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. we describe the algorithm that was applied to construct the pedigrees. for > 30,000 adolescent and adult ntr participants data were available on harmonized neuroticism ... | 2018 | 29043520 |
| an assessment in spondyloarthritis international society (asas)-endorsed definition of clinically important worsening in axial spondyloarthritis based on asdas. | in a previous phase, 12 draft definitions for clinically important worsening in axial spondyloarthritis (axspa) were selected, of which 3 were based on absolute changes in ankylosing spondylitis disease activity score (asdas)-crp (asdas). the objective here was to select the best cut-off for asdas for clinically important worsening in axspa for use in clinical trials and observational studies. | 2018 | 29038299 |
| ctx-m-15-producing shewanella species clinical isolate expressing oxa-535, a chromosome-encoded oxa-48 variant, putative progenitor of the plasmid-encoded oxa-436. | shewanella spp. constitute a reservoir of antibiotic resistance determinants. in a bile sample, we identified three extended-spectrum-β-lactamase (esbl)-producing bacteria (escherichia coli, klebsiella pneumoniae, and shewanella sp. strain jab-1) isolated from a child suffering from cholangitis. our objectives were to characterize the genome and the resistome of the first esbl-producing isolate of the genus shewanella and determine whether plasmidic exchange occurred between the three bacterial ... | 2018 | 29038283 |
| novel gene encoding 5-aminosalicylate 1,2-dioxygenase from comamonas sp. strain qt12 and catalytic properties of the purified enzyme. | the 1,125-bp mabb gene encoding 5-aminosalicylate (5asa) 1,2-dioxygenase, a nonheme iron dioxygenase in the bicupin family that catalyzes the cleavage of the 5asa aromatic ring to form cis-4-amino-6-carboxy-2-oxohexa-3,5-dienoate in the biodegradation of 3-aminobenzoate, was cloned from comamonas sp. strain qt12 and characterized. the deduced amino acid sequence of the enzyme has low sequence identity with that of other reported ring-cleaving dioxygenases. mabb was heterologously expressed in es ... | 2018 | 29038259 |
| co-fermentation of red grapes and white pomace: a natural and economical process to modulate hybrid wine composition. | the impact of co-fermenting white grape pomace (wp) and red grape pomace (rp) on the composition of interspecific hybrid wine was studied using the vitis sp. 'frontenac' and 'vidal'. the proanthocyanidin and anthocyanin content of the resulting wines were analysed by hplc-fluorescence and uplc-ms/ms, respectively. the cielab parameters and volatile compounds were analysed using spectrophotometry-uv and gc-ms-spme, respectively. the wp addition increased the concentration of monomeric and oligome ... | 2018 | 29037718 |
| microrna 221 targets adam10 mrna and is downregulated in alzheimer's disease. | adam10 is the α-secretase that cleaves amyloid-β protein precursor in the non-amyloidogenic pathway in alzheimer's disease (ad) and is known to be regulated by different micrornas (mirnas), which are post-transcriptional regulators related to several biological and pathological processes, including ad. here we proposed to explore and validate mirnas that have direct or indirect relations to the ad pathophysiology and adam10 gene. approximately 700 mirnas were analyzed and 21 differentially expre ... | 2018 | 29036829 |
| photobiomodulation of local alterations induced by bthtx-i, a phospholipase a2 myotoxin from bothrops jararacussu snake venom: in vivo and in vitro evaluation. | this report describes the effect of photobiomodulation (pbm) on edema formation, leukocyte influx, prostaglandin e2 (pge2) biosynthesis and cytotoxicity caused by bothropstoxin-i (bthtx-i), a phospholipase a2 (pla2) homologue isolated from bothrops jararacussu snake venom. swiss mice or c2c12 cells were irradiated with low-level laser (lll) at 685nm wavelength, an energy density of 4.6j/cm2 and an irradiation time of 13s. to evaluate the effect on edema formation and leukocyte influx, lll was ap ... | 2018 | 29037876 |
| fluoride toothpastes containing micrometric or nano-sized sodium trimetaphosphate reduce enamel erosion in vitro. | to evaluate the effect of fluoride toothpastes supplemented with micrometric or nano-sized sodium trimetaphosphate (tmp or tmpnano, respectively) on enamel erosion in vitro, as well as the influence of salivary acquired pellicle and saliva. | 2018 | 29037096 |
| testicular cytology by fine needle aspiration in domestic cats. | in cases where semen collection in tom-cats is not possible, fna of testes is the alternative to evaluate sperm production. although this technique for the diagnosis of fertility problems has been well discussed in other mammals (men, dogs, stallions), data for domestic cats are limited. therefore, the aim of this study was to verify the reliability of fna using needles of small diameters (22g and 29g) in testes of domestic cats of different ages to assess the spermatogenesis status and to prese ... | 2018 | 29035837 |
| can poly-parameter linear-free energy relationships (pp-lfers) improve modelling bioaccumulation in fish? | a wide range of studies have characterized different types of biosorbent, with regard to their interactions with chemicals. this has resulted in the development of poly-parameter linear free energy relationships (pp-lfers) for the estimation of partitioning of neutral organic compounds to biological phases (e.g., storage lipids, phospholipids and serum albumins). the aims of this study were to explore and evaluate the influence of implementing pp-lfers both into a one-compartment fish model and ... | 2018 | 29035795 |
| an easy way to detect dengue virus using nanoparticle-antibody conjugates. | the aim of the present research is to propose a new method based on localized surface plasmon resonance (lspr) for fast dengue virus detection. a pool with four dengue serotypes (denv-1, -2, -3, -4) was detected through antigen-antibody binding using gold nanoparticles (aunps) as signaling antibody carriers. such result was confirmed through surface plasmon resonance (spr), transmission electron microcopy (tem), and dynamic light scattering (dls) techniques. the limit of detection was calculated ... | 2018 | 29035789 |
| the albumin-bilirubin grade uncovers the prognostic relationship between hepatic reserve and immune dysfunction in hiv-associated hepatocellular carcinoma. | hepatocellular carcinoma (hcc) is a leading cause of liver-related mortality in people living with hiv, where co-infection with hepatotropic viruses accelerates the course of chronic liver disease. | 2018 | 29034998 |
| biodegradation of triclosan in diatom navicula sp.: kinetics, transformation products, toxicity evaluation and the effects of ph and potassium permanganate. | triclosan (tcs) is one of the most widely used pharmaceutically active compounds and frequently detected in treated wastewater and the impacted aquatic environment. however, the fate and toxicity of tcs in aquatic organisms is poorly known, including in particular the potential for the formation of incomplete biological transformation products. in this study, tcs posed high toxic effects (e.g., growth inhibition and damage of photosynthesis) to typical freshwater diatom navicula sp., with the 24 ... | 2018 | 29035714 |
| editorial comment: laparoscopic pectopexy: initial experience of single center with a new technique for apical prolapse surgery. | 2018 | 29035475 | |
| ultra-processed foods, protein leverage and energy intake in the usa. | experimental studies have shown that human macronutrient regulation minimizes variation in absolute protein intake and consequently energy intake varies passively with dietary protein density ('protein leverage'). according to the 'protein leverage hypothesis' (plh), protein leverage interacts with a reduction in dietary protein density to drive energy overconsumption and obesity. worldwide increase in consumption of ultra-processed foods (upf) has been hypothesized to be an important determinan ... | 2018 | 29032787 |
| estimation of sensitivity and specificity of pregnancy diagnosis using transrectal ultrasonography and elisa for pregnancy-associated glycoprotein in dairy cows using a bayesian latent class model. | to determine the sensitivity (se) and specificity (sp) of pregnancy diagnosis using transrectal ultrasonography and an elisa for pregnancy-associated glycoprotein (pag) in milk, in lactating dairy cows in seasonally calving herds approximately 85-100 days after the start of the herd's breeding period. | 2018 | 29032721 |
| impaired chemosensory control of breathing after depletion of bulbospinal catecholaminergic neurons in rats. | bulbospinal catecholaminergic neurons located in the rostral aspect of the ventrolateral medulla (c1 neurons) or within the ventrolateral pons (a5 neurons) are involved in the regulation of blood pressure and sympathetic outflow. a stimulus that commonly activates the c1 or a5 neurons is hypoxia, which is also involved in breathing activation. although pharmacological and optogenetic evidence suggests that catecholaminergic neurons also regulate breathing, a specific contribution of the bulbospi ... | 2018 | 29032505 |
| influence of platform diameter in the reliability and failure mode of extra-short dental implants. | to evaluate the influence of implant diameter in the reliability and failure mode of extra-short dental implants. | 2018 | 29032313 |
| cytokine profile changes in gingival crevicular fluid after placement different brackets types. | the aim of this study was to examine the relationship between bracket design and ratio of five proinflammatory cytokine, in gingival crevicular fluid (gcf), and bacterial adhesion without tooth movement influence. | 2018 | 29032048 |
| recoveries of rare elements ga, ge, in and sn from waste electric and electronic equipment through secondary copper smelting. | the recycling and recovery of valuable metals from waste materials is one of the key issues in maintaining the sustainability of base and rare metals. especially weee (waste electric and electronic equipment) can be considered as a high potential resource for a number of valuable and critical metals like gallium, germanium and indium. during the mechanical processing of weee, these metals are primary separated into the non-ferrous scrap fractions, including copper fraction. as a consequence, the ... | 2018 | 29032002 |
| use of comparative genomics-based markers for discrimination of host specificity in fusarium oxysporum. | the polyphyletic nature of many formae speciales of fusarium oxysporum prevents molecular identification of newly encountered strains based on conserved, vertically inherited genes. alternative molecular detection methods that could replace labor- and time-intensive disease assays are therefore highly desired. effectors are functional elements in the pathogen-host interaction and have been found to show very limited sequence diversity between strains of the same forma specialis, which makes them ... | 2018 | 29030446 |
| novel metabolic pathway for n-methylpyrrolidone degradation in alicycliphilus sp. strain bq1. | the molecular mechanisms underlying the biodegradation of n-methylpyrrolidone (nmp), a widely used industrial solvent that produces skin irritation in humans and is teratogenic in rats, are unknown. alicycliphilus sp. strain bq1 degrades nmp. by studying a transposon-tagged mutant unable to degrade nmp, we identified a six-gene cluster (nmpabcdef) that is transcribed as a polycistronic mrna and encodes enzymes involved in nmp biodegradation. nmpa and the transposon-affected gene nmpb encode an n ... | 2018 | 29030443 |
| activating inert alkali-metal ions by electron transfer from manganese oxide for formaldehyde abatement. | alkali-metal ions often act as promoters rather than active components due to their stable outermost electronic configurations and their inert properties in heterogeneous catalysis. herein, inert alkali-metal ions, such as k+ and rb+ , are activated by electron transfer from a hollandite-type manganese oxide (hmo) support for hcho oxidation. results from synchrotron x-ray diffraction, absorption, and photoelectron spectroscopies demonstrate that the electronic density of states of single alkali- ... | 2018 | 29030889 |
| is the microcosm approach using meiofauna community descriptors a suitable tool for ecotoxicological studies? | the usual approaches used in ecological risk assessment have been based on individual and population level standard procedures. although these have been important tools to assess adverse effects on ecosystems, they are generally simplified and therefore lack ecological realism. microcosm studies using meiobenthic communities offer a good compromise between the complexity of the ecosystem and the often highly artificial settings of laboratory experiments. an experiment was designed to investigate ... | 2018 | 29029380 |
| a new anthropophilic species of simulium (trichodagmia) (diptera: simuliidae) from amazonia: morphology, chromosomes, and dna sequences. | the black fly simulium (trichodagmia) hirtipupa lutz (diptera: simuliidae) is widely distributed in southern brazil, with one report from amapá state in the northern region of brazilian amazonia. morphological comparison of northern and southern populations revealed differences in all life stages, corroborated by chromosomal and molecular analyses, and indicated that the population previously identified as s. hirtipupa from amapá state represents an undescribed species. this new species is descr ... | 2018 | 29029329 |
| effects of intratracheal budesonide during early postnatal life on lung maturity of premature fetal rabbits. | this study aimed to study the effects of intratracheal instillation of budesonide on lung maturity of premature fetal rabbits. the developmental pattern of pulmonary alveoli in rabbits is similar to that in humans. | 2018 | 29028158 |
| biomass burning particles in the brazilian amazon region: mutagenic effects of nitro and oxy-pahs and assessment of health risks. | emissions from burning of biomass in the amazon region have adverse effects on the environment and human health. herein, particulate matter (pm) emitted from biomass burning in the amazon region during two different periods, namely intense and moderate, was investigated. this study focused on: i) organic characterization of nitro- and oxy-polycyclic aromatic hydrocarbons (pahs); ii) assessment of the excess lifetime cancer risk (lcr); and iii) assessment of the in vitro mutagenic effects of extr ... | 2018 | 29031407 |
| tropical soils are a reservoir for fluorescent pseudomonas spp. biodiversity. | fluorescent pseudomonas spp. are widely studied for their beneficial activities to plants. to explore the genetic diversity of pseudomonas spp. in tropical regions, we collected 76 isolates from a brazilian soil. genomes were sequenced and compared to known strains, mostly collected from temperate regions. phylogenetic analyses classified the isolates in the p. fluorescens (57) and p. putida (19) groups. among the isolates in the p. fluorescens group, most (37) were classified in the p. koreensi ... | 2018 | 29027341 |
| lipid-lowering agent-triggered dermatomyositis and polymyositis: a case series and literature review. | lipid-lowering agent-triggered dermatomyositis (dm) or polymyositis (pm) is a rare event. therefore, the aim of the present study was to describe a series of such cases. a retrospective cohort study of 5 dm and 4 pm cases triggered by prior exposure to lipid-lowering agents between 2001 and 2017 was carried out. all patients, except for two cases, had muscle biopsy compatible with inflammatory myopathy and no serum autoantibodies positive for anti-srp or anti-hmgcoar. median age of the patients ... | 2018 | 29027009 |
| a comparative study of full-thickness blepharotomy versus transconjunctival eyelid lengthening in the correction of upper eyelid retraction in graves' orbitopathy. | the study was designed to compare the outcome of full-thickness blepharotomy and transconjunctival eyelid lengthening in the correction of upper eyelid retraction (uer) in patients with graves' orbitopathy (go). | 2018 | 29026936 |
| correction to: 4-chloro-3-nitro-n-butylbenzenesulfonamide acts on kv3.1 channels by an open-channel blocker mechanism. | unfortunately, grey trace on figure 2c was missing in the original publication of the article. | 2018 | 29026918 |
| erratum to: quantitative physiology and elemental composition of kluyveromyces lactis cbs 2359 during growth on glucose at different specific growth rates. | in the original publication of the article, the below mentioned errors have appeared. the correct text is provided in this erratum, in the abstract section, the sentence "this dataset serve" should be replaced as "this dataset serves". also, the reference "basso to, gomes fs, lopes ml, et al (2014) homo- and heterofermentative lactobacilli differently affect sugarcane-based fuel ethanol fermentation. antonie van leeuwenhoek 105:169-177. doi: 10.1007/s10482-013-0063-6 " should be replaced as "bas ... | 2018 | 29027144 |
| bacterial and archaeal communities inhabiting mussels, sediment and water in indonesian anchialine lakes. | anchialine lakes are a globally rare and unique ecosystem consisting of saline lakes surrounded by land and isolated from the surrounding marine environment. these lakes host a unique flora and fauna including numerous endemic species. relatively few studies have, however, studied the prokaryote communities present in these lakes and compared them with the surrounding 'open water' marine environment. in the present study, we used a 16s rrna gene barcoded pyrosequencing approach to examine prokar ... | 2018 | 29027059 |
| exercise tolerance during muscle contractions below and above the critical torque in different muscle groups. | the objective of this study was to test the hypotheses that end-test torque (et) (expressed as % maximal voluntary contraction; mvc) is higher for plantar flexors (pf) than knee extensors (ke) muscles, whereas impulse above et (iet) is higher for ke than pf. thus, we expected that exercise tolerance would be longer for ke than pf only during the exercise performed above et. after the determination of mvc, 40 men performed two 5-min all-out tests to determine et and iet. eleven participants perfo ... | 2018 | 29024603 |
| developmental stage influences chromosome segregation patterns and arrangement in the extremely polyploid, giant bacterium epulopiscium sp. type b. | few studies have described chromosomal dynamics in bacterial cells with more than two complete chromosome copies or described changes with respect to development in polyploid cells. we examined the arrangement of chromosomal loci in the very large, highly polyploid, uncultivated intestinal symbiont epulopiscium sp. type b using fluorescent in situ hybridization. we found that in new offspring, chromosome replication origins (orics) are arranged in a three-dimensional array throughout the cytopla ... | 2018 | 29024073 |
| lower socioeconomic status is independently associated with shorter survival in hodgkin lymphoma patients-an analysis from the brazilian hodgkin lymphoma registry. | socioeconomic status (ses) is a well-known determinant of outcomes in cancer. the purpose of this study was to analyze the impact of the ses on the outcomes of hodgkin lymphoma (hl) patients from the brazilian prospective hl registry. ses stratification was done using an individual asset/education-based household index. a total of 624 classical hl patients with diagnosis from january/2009 to december/2014, and treated with abvd (doxorubicin, bleomycin, vinblastine and dacarbazine), were analyzed ... | 2018 | 29023692 |
| laboulbeniales parasitic on american small carrion beetles: new species of corethromyces, diphymyces, and rodaucea. | ten new species of laboulbeniales parasitic on small carrion beetles (coleoptera, leiodidae, cholevinae) from the american continent are described: corethromyces bernardii on dissochaetus spp. from bolivia, costa rica, ecuador, and the usa; diphymyces anthracinus on ptomaphagus brevior from the usa; d. blackwelliae on ptomaphagus giaquintoi from guatemala; d. costaricensis on adelopsis sp. from costa rica; d. dichromus on adelopsis marinae from argentina; d. newtonii on ptomaphagus fumosus from ... | 2018 | 29023208 |
| a proposal of brazilian society of surgical oncology for standardizing cytoreductive surgery plus hypertermic intraperitoneal chemotherapy procedures in brazil: pseudomixoma peritonei, appendiceal tumors and malignant peritoneal mesothelioma. | cytoreductive surgery plus hypertermic intraperitoneal chemotherapy has emerged as a major comprehensive treatment of peritoneal malignancies and is currently the standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome as well as malignant peritoneal mesothelioma. unfortunately, there are some worldwide variations of the cytoreductive surgery and hypertermic intraperitoneal chemotherapy techniques since no single technique has so far demonstrated its superiority ... | 2018 | 29019584 |
| effect of heat stress on production and in-vitro antioxidant activity of polysaccharides in ganoderma lucidum. | ganoderma lucidum is a traditional chinese medicine, and its polysaccharides possess diverse and significant pharmacological activities. this study aimed to investigate the polysaccharide production, molecular characteristics and in-vitro antioxidant activity of g. lucidum fruiting body after the mushroom was harvested and treated with heat stress (hs). hs enhanced the production of polysaccharides after harvest and treatment of 42 °c hs for 2 h, and that resulted in the highest polysaccharide y ... | 2018 | 29018957 |
| identification of platinum nanoparticles in road dust leachate by single particle inductively coupled plasma-mass spectrometry. | elevated platinum (pt) concentrations are found in road dust as a result of emissions from catalytic converters in vehicles. this study investigates the occurrence of pt in road dust collected in ghent (belgium) and gothenburg (sweden). total pt contents, determined by tandem icp-mass spectrometry (icp-ms/ms), were in the range of 5 to 79ngg-1, comparable to the pt content in road dust of other medium-sized cities. further sample characterization was performed by single particle (sp) icp-ms foll ... | 2018 | 29017127 |
| nickel phytoextraction through bacterial inoculation in raphanus sativus. | a pot experiment was conducted to evaluate the potential of two plant growth promoting rhizobacteria (pgpr) viz. bacillus sp. cik-516 and stenotrophomonas sp. cik-517y for improving the growth and ni uptake of radish (raphanus sativus) in the presence of four different levels of ni contamination (0, 50, 100, 150 mg ni kg-1 soil). plant growth, dry biomass, chlorophyll and nitrogen contents were significantly reduced by the exogenous application of ni, however, bacterial inoculation diluted the n ... | 2018 | 28992475 |
| microstructure and physical properties of nano-biocomposite films based on cassava starch and laponite. | the aim of this research was to study the effects of laponite concentrations on some properties of nano-biocomposite films based on cassava starch, focusing mainly the relation between the properties of the surface microstructure and roughness, water contact angle and gloss. nano-biocomposite films were produced by casting. we analyzed gloss, color, opacity, water contact angle, crystallinity by x-ray diffraction, and microstructure by scanning electron microscopy and atomic force microscopy. te ... | 2018 | 28993298 |
| structure, folding and stability of a minimal homologue from anemonia sulcata of the sea anemone potassium channel blocker shk. | peptide toxins elaborated by sea anemones target various ion-channel sub-types. recent transcriptomic studies of sea anemones have identified several novel candidate peptides, some of which have cysteine frameworks identical to those of previously reported sequences. one such peptide is ask132958, which was identified in a transcriptomic study of anemonia sulcata and has a cysteine framework similar to that of shk from stichodactyla helianthus, but is six amino acid residues shorter. we have det ... | 2018 | 28993277 |
| biochemical characterization and low-resolution saxs structure of an exo-polygalacturonase from bacillus licheniformis. | among the structural polymers present in the plant cell wall, pectin is the main component of the middle lamella. this heterogeneous polysaccharide has an α-1,4 galacturonic acid backbone, which can be broken by the enzymatic action of pectinases, such as exo-polygalacturonases, that sequentially cleave pectin from the non-reducing ends, releasing mono or di-galacturonic acid residues. constant demand for pectinases that better suit industrial requirements has motivated identification and charac ... | 2018 | 28993256 |
| comparing parents' and overweight adolescents' reports on parent mealtime actions. | this study aimed to compare answers given by parents and their adolescent children to the portuguese version of the parent mealtime action scale (pmas) and to assess associations among the reported behaviors. to compare these answers, a cross-sectional study was conducted in a sample of 72 patients of the obesity clinic of the division of nutrology of the pediatrics department at the federal university of são paulo (unifesp), brazil. these patients were aged from 10 years to 19 years and 11 mont ... | 2018 | 28993176 |
| isolation and screening of rare actinobacteria, a new insight for finding natural products with antivascular calcification activity. | vascular calcification (vc) is a significant pathological process in some life-threatening diseases. several pathological mechanisms, including transdifferentiation of vascular smooth muscle cells to osteoblast-like cells and apoptosis are involved in vc. compounds with an inhibitory effect on these processes are potentially efficient medications. in consideration of the multiple biological activities of actinobacteria, this research was aimed at finding anti-vc metabolite-producing actinobacter ... | 2018 | 28990259 |
| sociodemographic, anthropometric and behavioural risk factors for ultra-processed food consumption in a sample of 2-9-year-olds in brazil. | the present study aimed to identify food patterns among 2-9-year-olds and investigate sociodemographic, anthropometric and behavioural predictors of less healthy dietary patterns. | 2018 | 28988543 |
| heterologous expression of homo sapiens alpha-folate receptors in e. coli by fusion with a trigger factor for enhanced solubilization. | the role of alpha folate receptors (frα) in folate metabolism and cancer development has been extensively studied. the reason for this is not only associated to its direct relation to disease development but also to its potential use as a highly sensitive and specific biomarker for cancers therapies. over the recent years, the crystal structures of human frα complexed with different ligands were described relying on an expensive and time-consuming production process. here, we constructed an effi ... | 2018 | 28988145 |
| degradation of nonylphenol polyethoxylates by functionalized fe3o4 nanoparticle-immobilized sphingomonas sp. y2. | in this study, the efficiency of the nonylphenol polyethoxylates (npeos)-degrading bacterium sphingomonas sp. strain y2 was evaluated, which was immobilized by a novel system composed of polydopamine (pd)-coated fe3o4 iron nanoparticles (ionps). the pd-ionps, with a distinct core-shell structure, relatively uniform size, and high saturation magnetization, were prepared for y2 immobilization. the performance of y2 was unaffected by this novel immobilization method, exhibiting 79.5% and 99.9% of n ... | 2018 | 28988082 |
| comparing the effects of adapting to a weight on one leg during treadmill and overground walking: a pilot study. | locomotor adaptation has been suggested as a way to improve gait symmetry in individuals post-stroke. most perturbation methods utilize costly, specialized equipment. the use of a unilateral leg weight may provide a low cost, clinically translatable alternative. furthermore, previous studies have suggested that adaptation context may affect movement outcomes. the purpose of this study was to assess the ability of a unilaterally applied ankle weight to drive locomotor adaptation and determine the ... | 2018 | 28987764 |
| enhance wastewater biological treatment through the bacteria induced graphene oxide hydrogel. | the interaction between bacteria and graphene-family materials like pristine graphene, graphene oxide (go) and reduced graphene oxide (rgo) is such an elusive issue that its implication in environmental biotechnology is unclear. herein, two kinds of self-assembled bio-rgo-hydrogels (bghs) were prepared by cultivating specific shewanella sp. strains with go solution for the first time. the microscopic examination by sem, tem and clsm indicated a porous 3d structure of bghs, in which live bacteria ... | 2018 | 28987409 |
| fluorine-doped carbon nanotubes as an efficient metal-free catalyst for destruction of organic pollutants in catalytic ozonation. | metal-free carbon materials have been presented to be potential alternatives to metal-based catalysts for heterogeneous catalytic ozonation, yet the catalytic performance still needs to be enhanced. doping carbon with non-metallic heteroatoms (e.g., n, b, and f) could alter the electronic structure and electrochemical properties of original carbon materials, has been considered to be an effective method for improving the catalytic activity of carbon materials. herein, fluorine-doped carbon nanot ... | 2018 | 28987402 |
| the role of graphene-based sorbents in modern sample preparation techniques. | the application of graphene-based sorbents in sample preparation techniques has increased significantly since 2011. these materials have good physicochemical properties to be used as sorbent and have shown excellent results in different sample preparation techniques. graphene and its precursor graphene oxide have been considered to be good candidates to improve the extraction and concentration of different classes of target compounds (e.g., parabens, polycyclic aromatic hydrocarbon, pyrethroids, ... | 2018 | 28985018 |
| biocatalytic conversion of cycloalkanes to lactones using an in-vivo cascade in pseudomonas taiwanensis vlb120. | chemical synthesis of lactones from cycloalkanes is a multi-step process challenged by limitations in reaction efficiency (conversion and yield), atom economy (by-products) and environmental performance. a heterologous pathway comprising novel enzymes with compatible kinetics was designed in pseudomonas taiwanensis vlb120 enabling in-vivo cascade for synthesizing lactones from cycloalkanes. the respective pathway included cytochrome p450 monooxygenase (chx), cyclohexanol dehydrogenase (cdh), and ... | 2018 | 28986995 |
| isolation of cancer stem cells by side population method. | the hoechst side population (sp) method is a flow cytometry technique used to obtain stem cells based on the dye efflux properties of the atp-binding cassette (abc) transporters. the sp cells are characterized by their capability to efflux the fluorescent dna-binding dye hoechst 33342 through their abc transporters and are enriched in stem cells, which are endowed with a self-renewal capacity and multilineage differentiation potential and express the stemness genes including abc multidrug transp ... | 2018 | 28986886 |
| soybean peroxidase immobilized on δ-feooh as new magnetically recyclable biocatalyst for removal of ferulic acid. | a significant enhancement in the catalytic performance due to enzymes immobilization is a great way to enhance the economics of biocatalytic processes. the soybean peroxidase (sp) immobilization under ferroxyte and the ferulic acid removal by the enzyme free and immobilized were investigated. the immobilization via silica-coated ferroxyte nanoparticles was effective, and immobilization yield of 39%. the scanning electron microscopy (sem) images showed significant changes in the materials morphol ... | 2018 | 28986654 |
| validation of an indirect elisa employing a chimeric recombinant gag and env peptide for the serological diagnosis of equine infectious anemia. | the national reference center for equine infectious anemia (eia) validated a commercial elisa (eradikit® eiav indirect elisa, in3diagnostic®, turin, italy) employing a chimeric recombinant gag and env peptide for the detection of eia virus antibodies, following the guidelines of the world organization for animal health. the validation parameters evaluated were: analytical sensitivity (se) and specificity (sp); diagnostic se and sp; precision, based on repeatability and reproducibility through th ... | 2018 | 28986292 |
| validation of calcaneus trabecular microstructure measurements by hr-pqct. | assessment of calcaneus microstructure using high-resolution peripheral quantitative computed tomography (hr-pqct) might be used to improve fracture risk predictions or to assess responses to pharmacological and physical interventions. to develop a standard clinical protocol for the calcaneus, we validated calcaneus trabecular microstructure measured by hr-pqct against 'gold-standard' micro-ct measurements. | 2018 | 28986143 |
| environmental pollution affects molecular and biochemical responses during gonadal maturation of astyanax fasciatus (teleostei: characiformes: characidae). | endocrine disrupting compounds (edcs) have the potential to alter fish reproduction at various levels of organization. the aim of this study was to assess the impact of a natural environment with heavily anthropogenic influence on the physiological processes involved in reproduction in the freshwater fish lambari (astyanax fasciatus) using different biomarkers. adult males and females were collected in different seasons from two distinct sites in the same watershed: ponte nova reservoir (pn) con ... | 2018 | 28985654 |
| a cross-sectional study of intestinal parasitoses in dogs and children of the periurban area of la plata (buenos aires, argentina): zoonotic importance and implications in public health. | a cross-sectional study was performed between school term dates 2014 and 2015 to diagnose intestinal parasites in dogs and children living with them. the socio-environmental characteristics and hygiene practices of the children were also evaluated in terms of risk factors for parasitic infection of periurban neighbourhoods of la plata (buenos aires, argentina). serial coproparasitological samples of 78 dogs and 211 children were analysed by means of concentration and flotation techniques. socio- ... | 2018 | 28984036 |
| multi-step approach to add value to corncob: production of biomass-degrading enzymes, lignin and fermentable sugars. | this work presents an integrated and multi-step approach for the recovery and/or application of the lignocellulosic fractions from corncob in the production of high value added compounds as xylo-oligosaccharides, enzymes, fermentable sugars, and lignin in terms of biorefinery concept. for that, liquid hot water followed by enzymatic hydrolysis were used. liquid hot water was performed using different residence times (10-50min) and holding temperature (180-200°c), corresponding to severities (log ... | 2018 | 28982088 |
| enhanced growth and fatty acid accumulation of microalgae scenedesmus sp. lx1 by two types of auxin. | microalgae are potential candidates for the production of valuable products, such as renewable biodiesel, health products and pigments. however, low biomass productivity has restricted their large-scale applications. in this study, the effects of two auxins (one natural type of indole-3-acetic acid (iaa) and the other synthetic type of 2,4-dichlorophenoxyacetic acid (2,4-d)) on the growth and fatty acid methyl esters (fames) production of a freshwater microalgae scenedesmus sp. lx1 were investig ... | 2018 | 28982085 |
| retrospective survey for pathogens in stranded marine mammals in northeastern brazil: brucella spp. infection in a clymene dolphin ( stenella clymene). | : we surveyed 13 carcasses of marine mammals (12 trichechus manatus and one stenella clymene) that had stranded in northeastern brazil during 1990-2013 for infectious diseases by screening tissues from the collection of the brazilian national center of research and conservation of aquatic mammal, chico mendes institute for biodiversity conservation. brucella spp. and mycobacterium spp. were investigated by culturing and pcr of tissue samples, whereas sarcocystidae parasites, leptospira spp., an ... | 2018 | 28982019 |
| chitinophaga salinisoli sp. nov., isolated from saline soil. | a novel aerobic bacterium, designated strain lam9153t, was isolated from a saline soil sample collected from lingxian county, shandong province, china. cells of strain lam9153t were observed to be gram-stain negative, non-motile, non-spore-forming and rod-shaped. the new isolate grew optimally at 30-35 °c, ph 7.0 and 0.5% of nacl concentration (w/v). according to the phylogenetic analysis based on the 16s rrna gene sequence, strain lam9153t shares high similarity with chitinophaga terrae gsoil 2 ... | 2018 | 28980087 |
| trypanosoma cruzi and leishmania sp. infection in wildlife from urban rainforest fragments in northeast brazil. | : trypanosoma cruzi and leishmania sp. are important protozoan parasites for humans and animals in the americas, causing chagas disease and cutaneous or visceral leishmaniasis, respectively. these vector-borne diseases affect permanent and transient populations in developing tropical countries that exhibit favorable conditions for the perpetuation of the parasite cycle. our objective was to investigate the occurrence of infection with these parasites in wild animals from urban rainforest fragme ... | 2018 | 28977769 |
| the fast clinical evolution of a spitz nevus: three-year follow-up of a child. | to report the clinical evolution and handling of a spitz nevus, from its initial flat feature to becoming an irregular, nodular, reddish lesion. | 2018 | 28977136 |
| systematic literature review on models and practices of early childhood intervention in brazil. | to identify which early childhood intervention practices and models are described in the brazilian literature. | 2018 | 28977135 |
| bone mass by quantitative ultrasound of finger phalanges in young karate practitioners. | to evaluate bone mass by quantitative ultrasound of the phalanges in young karate practitioners compared to a control group. | 2018 | 28977128 |
| prevalence of genu valgum in public elementary schools in the city of santos (sp), brazil. | to evaluate the prevalence of genu valgum and associated factors in elementary school students. | 2018 | 28977127 |
| temperament and character traits in major depressive disorder: a case control study. | patients with major depressive disorder (mdd) have distinct personality traits, compared with control subjects, although the role of anxiety and positive and negative affects in this finding is unclear. | 2018 | 28977097 |
| diagnostic utilities of a fully automated molecular test for toxigenic clostridium difficile. | laboratory underdiagnosis of toxigenic clostridium difficile can lead to inappropriate management of c. difficile infection (cdi). a fully automated molecular test (famt), bd max, and enzyme immunoassays for c. difficile glutamate dehydrogenase (gdh) and for toxin a/b antigen test were evaluated using clinical specimens. laboratory analysis of 231 fecal specimens from patients suspected with cdi, indicated that the sensitivity (sn), specificity (sp), positive predictive value (ppv), and negative ... | 2018 | 28974364 |
| proteinivorax hydrogeniformans sp. nov., an anaerobic, haloalkaliphilic bacterium fermenting proteinaceous compounds with high hydrogen production. | a search for the organisms responsible for the degradation of biomass of primary producers in tanatar lakes resulted in the isolation of a novel anaerobic, haloalkaliphilic microorganism, strain z-710t. the strain grows on proteinaceous substrates (peptides) but not on proteins. a rather limited range of substances of other classes can be utilised together with tryptone but not individually. an interesting physiological feature of the novel strain is a high capacity for hydrogen production (up t ... | 2018 | 28975474 |
| the influence of spirituality and religiousness on suicide risk and mental health of patients undergoing hemodialysis. | despite the large amount of literature assessing how spiritual and religious beliefs have an impact on mental health and suicide risk in various groups of patients, few studies have investigated patients with chronic kidney disease (ckd). the purpose of this study is to investigate whether spirituality and religiousness (s/r) are associated with the presence of suicide risk as well as whether those beliefs are also associated with the presence of mental health problems in patients undergoing hem ... | 2018 | 28972917 |
| integrating microalgae tertiary treatment into activated sludge systems for energy and nutrients recovery from wastewater. | in this study, microalgae digestate and secondary effluent were used to grow microalgae in a tertiary wastewater treatment, and then, the biomass was co-digested for biogas generation. a 30l closed-photobioreactor was used for microalgae cultivation. the biomass, mainly composed by scenedesmus sp., reached and maintained a concentration of 1.1gtss/l during 30days. a complete removal of n-nh4+ and p-po43- and high nitrates and organic matter removals were achieved (58% n-no3- and 70% cod) with 8d ... | 2018 | 28972904 |
| prospective and randomized clinical trial comparing transobturator versus retropubic sling in terms of efficacy and safety. | the midurethral sling is the most commonly performed surgical procedure for stress urinary incontinence (sui). we compared the efficacy of transobturator tape (tot) and retropubic (rp) slings by evaluating objective and subjective cure rates at 12 months postsurgery and evaluate the impact on quality of life (qol) and record intra- and postoperative complications. | 2018 | 28971224 |
| molecular diagnosis of symptomatic toxoplasmosis: a 9-year retrospective and prospective study in a referral laboratory in são paulo, brazil. | symptomatic forms of toxoplasmosis are a serious public health problem and occur in around 10-20% of the infected people. aiming to improve the molecular diagnosis of symptomatic toxoplasmosis in brazilian patients, this study evaluated the performance of real time pcr testing two primer sets (b1 and rep-529) in detecting toxoplasma gondii dna. the methodology was assayed in 807 clinical samples with known clinical diagnosis, elisa, and conventional pcr results in a 9-year period. all samples we ... | 2018 | 28968510 |
| cancer survival in people with aids: a population-based study from são paulo, brazil. | cancer survival among people with aids (pwa) has been described in developed countries, but there is lack of data from developing countries. the aim of this study was to evaluate survival after cancer diagnosis in pwa and compare it with people without aids (non-pwa) in são paulo, brazil. a probabilistic record linkage was carried out between the databases of the population-based cancer registry of são paulo (pbcr-sp) and the aids registry of sp (sinan) to identify pwa who developed cancer. for ... | 2018 | 28971480 |
| three-dimensional cardiovascular imaging-genetics: a mass univariate framework. | left ventricular (lv) hypertrophy is a strong predictor of cardiovascular outcomes, but its genetic regulation remains largely unexplained. conventional phenotyping relies on manual calculation of lv mass and wall thickness, but advanced cardiac image analysis presents an opportunity for high-throughput mapping of genotype-phenotype associations in three dimensions (3d). | 2018 | 28968671 |
| clinical, laboratory, and demographic determinants of hospitalization due to dengue in 7613 patients: a retrospective study based on hierarchical models. | in brazil, the incidence of hospitalization due to dengue, as an indicator of severity, has drastically increased since 1998. the objective of our study was to identify risk factors associated with subsequent hospitalization related to dengue. we analyzed 7613 dengue confirmed via serology (elisa), non-structural protein 1, or polymerase chain reaction amplification. we used a hierarchical framework to generate a multivariate logistic regression based on a variety of risk variables. this was fol ... | 2018 | 28964768 |
| reticulate pleistocene evolution of ethiopian rodent genus along remarkable altitudinal gradient. | the ethiopian highlands are the most extensive complex of mountainous habitats in africa. the presence of the great rift valley (grv) and the striking elevational ecological gradients inhabited by recently radiated ethiopian endemics, provide a wide spectrum of model situations for evolutionary studies. the extant species of endemic rodents, often markedly phenotypically differentiated, are expected to possess complex genetic features which evolved asa consequence of the interplay between geomor ... | 2018 | 28963084 |
| serological and molecular markers of hepatitis e virus infection in hiv-infected patients in brazil. | in brazil, the circulation of hepatitis e virus (hev) has been demonstrated in distinct groups of individuals and some animals, but its prevalence among individuals with human immunodeficiency virus (hiv) infection is unknown. this study aimed to assess the frequency of serological and molecular hev markers in individuals infected with hiv from são paulo, brazil. serum and plasma samples of 354 hiv-infected patients collected between 2007 and 2013 were included. all samples were tested for anti- ... | 2018 | 28965214 |
| growth kinetic and fuel quality parameters as selective criterion for screening biodiesel producing cyanobacterial strains. | the efficiency of cyanobacterial strains as biodiesel feedstock varies with the dwelling habitat. fourteen indigenous heterocystous cyanobacterial strains from rice field ecosystem were screened based on growth kinetic and fuel parameters. the highest biomass productivity was obtained in nostoc punctiforme mbdu 621 (19.22mg/l/day) followed by calothrix sp. mbdu 701 (13.43mg/l/day). while lipid productivity and lipid content was highest in nostoc spongiaeforme mbdu 704 (4.45mg/l/day and 22.5%dwt) ... | 2018 | 28965076 |
| enhanced degradation of prometryn and other s-triazine herbicides in pure cultures and wastewater by polyvinyl alcohol-sodium alginate immobilized leucobacter sp. jw-1. | the s-triazine herbicides, such as prometryn, have been widely used in agriculture and have raised much public concern over their contamination of water and soil. leucobacter sp. jw-1 cells were immobilized in polyvinyl alcohol‑sodium alginate (pva-sa) beads and then used to degrade prometryn. orthogonal array experiments showed that the optimal immobilization conditions of pva-sa immobilized leucobacter sp. jw-1 beads (pslbs) were 3% jw-1 cells (w/v, wet weight), 10-12% (w/v) pva, 2-3% (w/v) ca ... | 2018 | 28963898 |
| influence of pre-irradiation time employed in antimicrobial photodynamic therapy with diode laser. | the aim of the present study was to evaluate, in vitro, the effect of different pre-irradiation times of the photosensitizer in photodynamic therapy in biofilms formed by streptococcus mutans and candida albicans, through the evaluation of the microbial load. the factors under study were as follows: times of pre-irradiation of the photosensitizer in three levels (1, 2, or 5 min). for the control of the cariogenic dental biofilm with antimicrobial photodynamic therapy (apdt), methylene blue (0.01 ... | 2018 | 28963589 |
| temperature-dependence of predator-prey dynamics in interactions between the predatory fungus lecophagus sp. and its prey l. inermis rotifers. | temperature is considered an important factor that influences the bottom-up and top-down control in water habitats. we examined the influence of temperature on specific predatory-prey dynamics in the following two-level trophic system: the predatory fungus lecophagus sp. and its prey lecane inermis rotifers, both of which originated from activated sludge obtained from a wastewater treatment plant (wwtp). the experiments investigating the ability of conidia to trap rotifers and the growth of fung ... | 2018 | 28963577 |
| environmental risk assessment of triclosan and ibuprofen in marine sediments using individual and sub-individual endpoints. | the guidelines for the environmental risk assessment (era) of pharmaceuticals and personal care products (ppcp) recommend the use of standard ecotoxicity assays and the assessment of endpoints at the individual level to evaluate potential effects of ppcp on biota. however, effects at the sub-individual level can also affect the ecological fitness of marine organisms chronically exposed to ppcp. the aim of the current study was to evaluate the environmental risk of two ppcp in marine sediments: t ... | 2018 | 28958726 |
| transglutaminase from newly isolated streptomyces sp. cbmai 1617: production optimization, characterization and evaluation in wheat protein and dough systems. | the popularity of transglutaminase (tg) by the food industry and the variation in functionality of this enzyme from different origins, prompted us to isolate and evaluate a high-yielding tg strain. through the statistical approaches, plackett-burman and response surface methodology, a low cost fermentation media was obtained to produce 6.074±0.019uml-1 of tg from a novel source; streptomyces sp. cbmai 1617 (sb6). its potential exploitation was compared to commonly used tg, from streptomyces moba ... | 2018 | 28958547 |
| encapsulating anthocyanins from hibiscus sabdariffa l. calyces by ionic gelation: pigment stability during storage of microparticles. | hibiscus extract (he) has a strong antioxidant activity and high anthocyanin content; it can be used as a natural pigment, also adding potential health benefits. the objective of this work was the microencapsulation of he anthocyanin by ionic gelation (ig) using two techniques: dripping-extrusion and atomization, both by means of a double emulsion (he/rapseed oil/pectin) and a cross-linked solution (cacl2). particles (77-83% moisture content) were conditioned in acidified solution at 5, 15 and 2 ... | 2018 | 28958534 |
| hybrid geoid model: theory and application in brazil. | determination of the ellipsoidal height by global navigation satellite systems (gnss) is becoming better known and used for purposes of leveling with the aid of geoid models. however, the disadvantage of this method is the quality of the geoid models, which degrade heights and limit the application of the method. in order to provide better quality in transforming height using gnss leveling, this research aims to develop a hybridization methodology of gravimetric geoid models egm08, mapgeo2015 an ... | 2018 | 28954175 |
| biochemical and genetic analysis of a unique poly(adp-ribosyl) glycohydrolase (parg) of the pathogenic fungus fusarium oxysporum f. sp. lycopersici. | the genome sequence of the plant pathogen fusarium oxysporum f. sp. lycopersici contains a single gene encoding a predicted poly(adp-ribose) glycohydrolase (foxg_05947.2, parg). here, we assessed whether this gene has a role as a global regulator of dna repair or in virulence as an adp ribosylating toxin homologue of bacteria. the parg protein was purified after expressing its encoding gene in escherichia coli. its inhibition by 6,9-diamino-2-ethoxyacridine lactate monohydrate and tannins was si ... | 2018 | 28956188 |
| yolk sac primary tumor of mediastino: a rare case in a young adult. | germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). we report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. this was a 38-year-old man who was admitted to hospital do servidor público estadual "francisco morato de oliveira", complaining about dyspnea and dry cough for 1 year. the computed tomograph ... | 2018 | 28954036 |
| preimplantation genetic diagnosis associated to duchenne muscular dystrophy. | duchenne muscular dystrophy is the most common muscle disease found in male children. currently, there is no effective therapy available for duchenne muscular dystrophy patients. therefore, it is essential to make a prenatal diagnosis and provide genetic counseling to reduce the birth of such boys. we report a case of preimplantation genetic diagnosis associated with duchenne muscular dystrophy. the couple e.p.r., 38-year-old, symptomatic patient heterozygous for a 2 to 47 exon deletion mutation ... | 2018 | 28954035 |
| giant esophageal epiphrenic diverticulum: presentation and treatment. | epiphrenic diverticulum is a rare disease associated with esophageal motor disorders that is usually asymptomatic and has a well-established surgical indication. we report a case of giant epiphrenic diverticulum in a 59-year-old symptomatic woman who was diagnosed after underwent complementary exams. because of her symptoms, the surgical treatment was chosen, and esophageal diverticulectomy was performed along with laparoscopic cardiomyotomy and anterior partial fundoplication. | 2018 | 28954034 |