Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| lenalidomide, thalidomide, and pomalidomide reactivate the epstein-barr virus lytic cycle through phosphoinositide 3-kinase signaling and ikaros expression. | lenalidomide, thalidomide, and pomalidomide (ltp) are immunomodulatory agents approved for use in multiple myeloma, but in some settings, especially with alkylating agents, an increase in hodgkin lymphoma and other secondary primary malignancies (spm) has been noted. some of these malignancies have been linked to epstein-barr virus (ebv), raising the possibility that immunomodulatory drugs disrupt latent ebv infection. | 2016 | 27297582 |
| validation of an ifnγ/il2 fluorospot assay for clinical trial monitoring. | the fluorospot assay, an advancement of the elispot assay, enables simultaneous measurement of different analytes secreted at a single-cell level. this allows parallel detection of several cytokines secreted by immune cells upon antigen recognition. easier standardization, higher sensitivity and reduced labour intensity render fluorospot assays an interesting alternative to flow-cytometry based assays for analysis of clinical samples. while the use of immunoassays to study immunological primary ... | 2016 | 27297580 |
| integration of hiv in the human genome: which sites are preferential? a genetic and statistical assessment. | chromosomal fragile sites (fss) are loci where gaps and breaks may occur and are preferential integration targets for some viruses, for example, hepatitis b, epstein-barr virus, hpv16, hpv18, and mlv vectors. however, the integration of the human immunodeficiency virus (hiv) in giemsa bands and in fss is not yet completely clear. this study aimed to assess the integration preferences of hiv in fss and in giemsa bands using an in silico study. hiv integration positions from jurkat cells were used ... | 2016 | 27294106 |
| rabbits immunized with epstein-barr virus gh/gl or gb recombinant proteins elicit higher serum virus neutralizing activity than gp350. | epstein-barr virus (ebv) is the primary cause of infectious mononucleosis and has been strongly implicated in the etiology of multiple epithelial and lymphoid cancers, such as nasopharyngeal carcinoma, gastric carcinoma, hodgkin lymphoma, burkitt lymphoma, non-hodgkin lymphoma and post-transplant lymphoproliferative disorder. there is currently no licensed prophylactic vaccine for ebv. most efforts to develop prophylactic vaccines have focused on ebv gp350, which binds to cd21/cd35 to gain entry ... | 2016 | 27291087 |
| a review of nationwide population study of organ transplantation in taiwan. | solid organ transplantation has become the therapy of choice for patients with end-stage organ disease. the frequently transplanted organs in taiwan include liver, kidney, heart, and lung, and the success rate has improved significantly worldwide for the past decades. however, organ recipients are known to be at a higher risk of post-transplant infections and de novo cancer due to immunosuppression and oncogenic viral infections. organ recipients are known to be at a two- to fourfold increased r ... | 2016 | 27289565 |
| hemophagocytic lymphohistiocytosis: pathogenesis, diagnosis, and management. | hemophagocytic lymphohistiocytosis (hlh) is a life-threatening hyperinflammatory syndrome that is classified into primary and secondary hlh. primary hlh consists of monogenic disorders that mainly affect the perforin-mediated cytotoxicity of cytotoxic t lymphocytes and natural killer cells. secondary hlh occurs as a complication in various settings such as infection, malignancy, autoimmune disease, and post-allogeneic hematopoietic stem cell transplantation. both primary and secondary hlh are ch ... | 2016 | 27289085 |
| variable clinical phenotypes of x-linked lymphoproliferative syndrome in china: report of five cases with three novel mutations and review of the literature. | x-linked lymphoproliferative disease (xlp) is a rare life-threatening syndrome. rapid recognition and definitive diagnosis are critical to improve the prognosis and survival of patients with xlp. nowadays, little is known about patients with xlp in china. | 2016 | 27288720 |
| two unrelated burkitt lymphomas seven years apart in a patient with x-linked lymphoproliferative disease type 1 (xlp1). | we describe a rare case of a male child with x-linked lymphoproliferative disease type 1 (xlp1) who presented with burkitt lymphoma (bl) when he was 6 years old, achieved a complete response to therapy, and developed a second bl after seven years. | 2016 | 27287777 |
| detection of malawi polyomavirus sequences in secondary lymphoid tissues from italian healthy children: a transient site of infection. | the novel malawi polyomavirus (mwpyv) was initially detected in stool specimens from healthy children and children with gastrointestinal symptoms, mostly diarrhea, indicating that mwpyv might play a role in human gastroenteric diseases. recently, mwpyv sequences were additionally identified in respiratory secretions from both healthy and acutely ill children suggesting that mwpyv may have a tropism for different human tissues. this study was designed to investigate the possible sites of latency/ ... | 2016 | 27287743 |
| pulmonary manifestation of immunoglobulin g4-related disease in a 7-year-old immunodeficient boy with epstein-barr virus infection: a case report. | immunoglobulin g4-related disease (igg4-rd) is a multiorgan fibroinflammatory condition with lymphoplasmacytic infiltrates containing abundant igg4-positive plasma cells. the immunopathogenesis of the disease and the potential role of triggering autoantigens or infectious factors have not been clearly defined. immunoglobulin g4-related lung disease is a new and emerging condition in pediatric patients and to date, there have been only two reports regarding pulmonary manifestation of igg4-rd in c ... | 2016 | 27277432 |
| dress syndrome with autoimmune hepatitis from strontium ranelate. | strontium ranelate, which is used for postmenopausal osteoporosis, has been associated with drug rash with eosinophilia and systemic symptoms (dress) syndrome, a severe, acute, potentially fatal, multisystem adverse drug reaction characterized by skin rash, fever, hematological abnormalities, and lymphadenopathy with involvement of several internal organs. we report the case of a woman who developed dress syndrome with a generalized maculopapular rash, eosinophilia, dyspnea, bilateral cervical l ... | 2016 | 27274555 |
| associations between inflammatory cytokines and organ damage in pediatric patients with hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. most of the clinical and laboratory manifestations of hlh are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. the aim of this study was to investigate the associations between cytokines and various manifestations of hlh. a total of 105 patients diagnosed with hlh were enrolled in this retrospectiv ... | 2016 | 27269180 |
| chronic active epstein-barr virus infection with marked pericardial effusion successfully treated with allogeneic peripheral blood stem cell transplantation. | a 23-year-old woman presented with a persistent fever and shortness of breath. computed tomography showed marked pericardial effusion, hepatosplenomegaly, and cervical and mediastinal lymph node swelling. epstein-barr virus (ebv) antibody titers were abnormally elevated, and the copy number of ebv-dna was increased in peripheral blood. based on these observations, she was diagnosed with chronic active ebv infection (caebv). the ebv-infected cells in her peripheral blood were cd4(+)t lymphocytes. ... | 2016 | 27263789 |
| [myeloradiculitis due to epstein-barr virus reactivation in a hodgkin's lymphoma patient]. | 2016 | 27262573 | |
| the impact of long-term secukinumab treatment on epstein-barr virus and cytomegalovirus loads in patients with psoriasis. | 2016 | 27261186 | |
| pd-l1 expression is associated with massive lymphocyte infiltration and histology in gastric cancer. | the mechanism of carcinogenesis of gastric cancer (gc) is still unclear now. this study aimed to explore the correlations among pd-l1, epstein-barr virus (ebv) infection, lymphocyte infiltration, her2 expression, her2 gene status, histology, and other clinicopathological factors in gc. a total of 44 gc patients with massive lymphocyte infiltration (gc-mli) and 93 gc patients without massive lymphocyte infiltration were involved in this study. immunohistochemical analysis was used to test the exp ... | 2016 | 27260946 |
| post-transplant lymphoproliferative disorder of the pediatric airway: presentation and management. | post-transplant lymphoproliferative disorder (ptld) is a rare complication of immunosuppression with little consensus on its evaluation and management. the purpose of this contemporary review is to describe a pediatric patient with ptld of the airway and review the literature to provide multidisciplinary recommendations regarding management. | 2016 | 27260610 |
| overexpression of pin1 enhances cancer growth and aggressiveness with cyclin d1 induction in ebv-associated nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a peculiar epstein barr virus (ebv)-associated malignancy that is prevalent in south-east asia. peptidyl-prolyl cis-trans isomerase nima-interacting 1 (pin1) isomerizes specific phosphorylated amino acid residues, which makes it an important regulator in cell survival and apoptosis. in this study, we investigated the contribution made by pin1 in npc tumorigenesis and pin1's potential role as a therapeutic target. | 2016 | 27258148 |
| evaluation of the abbot architect(™) epstein-barr virus viral capsid antigen igm, viral capsid antigen igg and nuclear antigen igg assays in a pediatric and adult population. | the detection of antibodies against epstein-barr viral capsid (vca) and nuclear (ebna) antigens is routinely performed with different commercially available immunoassays. | 2016 | 27258036 |
| [an analysis of immunophenotyping of peripheral lymphocytes in adult patients with infectious mononucleosis and chronic active epstein-barr virus infection]. | to determine the immunophenotypic features of peripheral lymphocytes in adult patients with epstein-barr virus(ebv)-associated infectious mononucleosis(im) and chronic active ebv infection (caebv). | 2016 | 27256608 |
| ebv-lmp1 suppresses the dna damage response through dna-pk/ampk signaling to promote radioresistance in nasopharyngeal carcinoma. | we conducted this research to explore the role of latent membrane protein 1 (lmp1) encoded by the epstein-barr virus (ebv) in modulating the dna damage response (ddr) and its regulatory mechanisms in radioresistance. our results revealed that lmp1 repressed the repair of dna double strand breaks (dsbs) by inhibiting dna-dependent protein kinase (dna-pk) phosphorylation and activity. moreover, lmp1 reduced the phosphorylation of amp-activated protein kinase (ampk) and changed its subcellular loca ... | 2016 | 27255972 |
| antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis. | anti-citrullinated-peptide antibodies (acpa) have been detected in individuals with developing rheumatoid arthritis (ra) before the onset of symptom, with an initially limited spectrum of reactivities that gradually broadens. the aim was to analyze the evolution of acpa response pre-dating symptom onset, using four selected citrullinated exogenous and endogenous antigens. | 2016 | 27255888 |
| the ankylosing spondylitis-associated hla-b*2705 presents a b*0702-restricted ebv epitope and sustains the clonal amplification of cytotoxic t cells in patients. | hla-b*27 is strongly associated with an inflammatory autoimmune disorder, the ankylosing spondylitis (as) and plays a protective role in viral infections. the two aspects might be linked. in this work, we compared in b*2705/b*07 positive patients with as, the cd8+ t cell responses to two immunodominant ebv-derived epitopes restricted for either the hla-b*27 (pebna3c) or the hla-b*07 (pebna3a). we have unexpectedly found that the hla-b*07-restricted ebna3a peptide is presented by both the b*0702 ... | 2016 | 27254288 |
| cd1c-related dcs that express cd207/langerin, but are distinguishable from langerhans cells, are consistently present in human tonsils. | several subsets of dendritic cells (dcs) are present in the oropharyngeal tonsillar tissues and are thought to behave as major actors in development and regulation of immunity by acting as a first line of recognition for airborne and alimentary antigens. we previously discovered in human adult tonsils infected with epstein-barr virus (ebv), a subset of dcs that expressed langerin/cd207, a lectin usually recognized as a hallmark of epidermal langerhans cells (lcs). in the present study, we analyz ... | 2016 | 27252701 |
| cytomegalovirus and epstein-barr virus infections. | 2016 | 27252178 | |
| partial least square discriminant analysis discovered a dietary pattern inversely associated with nasopharyngeal carcinoma risk. | evidence on the association between dietary component, dietary pattern and nasopharyngeal carcinoma (npc) is scarce. a major challenge is the high degree of correlation among dietary constituents. we aimed to identify dietary pattern associated with npc and to illustrate the dose-response relationship between the identified dietary pattern scores and the risk of npc. taking advantage of a matched npc case-control study, data from a total of 319 incident cases and 319 matched controls were analyz ... | 2016 | 27249558 |
| viral oncomir spreading between b and t cells is employed by kaposi's sarcoma herpesvirus to induce non-cell-autonomous target gene regulation. | the two human lymphotrophic γ-herpesviruses, kaposi's sarcoma herpesvirus (kshv) and epstein-barr virus (ebv), are a recognized cause of human cancer, encoding multiple mirs that are major players in carcinogenesis. previously, we discovered that ebv-encoded mirs transfer between infected b and t lymphocytes. to further explore the biological significance of the spreading of γ-herpesvirus-encoded mirs on carcinogenesis, we focused on kshv-mir-k12-11 (mir-k12-11) that is unique in having an ident ... | 2016 | 27248822 |
| epstein-barr virus-induced gene 3 (ebi3) blocking leads to induce antitumor cytotoxic t lymphocyte response and suppress tumor growth in colorectal cancer by bidirectional reciprocal-regulation stat3 signaling pathway. | epstein-barr virus-induced gene 3 (ebi3) is a member of the interleukin-12 (il-12) family structural subunit and can form a heterodimer with il-27p28 and il-12p35 subunit to build il-27 and il-35, respectively. however, il-27 stimulates whereas il-35 inhibits antitumor t cell responses. to date, little is known about the role of ebi3 in tumor microenvironment. in this study, firstly we assessed ebi3, il-27p28, il-12p35, gp130, and p-stat3 expression with clinicopathological parameters of colorec ... | 2016 | 27247488 |
| development of a low-cost stem-loop real-time quantification pcr technique for ebv mirna expression analysis. | micrornas (mirnas) are short, single stranded, non-coding rna molecules. they are produced by many different species and are key regulators of several physiological processes. mirnas are also encoded by the genomes of multiple virus families, such as herpesvirus family. in particular, mirnas from epstein barr virus were found at high concentrations in different associated pathologies, such as burkitt's lymphoma, hodgkin disease, and nasopharyngeal carcinoma. thanks to their stability, these mole ... | 2016 | 27246439 |
| hemophagocytic lymphohistiocytosis in children: pathogenesis and treatment. | hemophagocytic lymphohistiocytosis (hlh) is a rare disorder in children that is characterized by persistent fever, splenomegaly with cytopenia, hypertriglyceridemia, and hypofibrinogenemia. increased levels of various cytokines and soluble interleukin-2 receptor are biological markers of hlh. hlh can be classified into two major forms: primary and secondary. familial hemophagocytic lymphohistiocytosis (fhl), a type of primary hlh, is an autosomal recessive disorder that typically occurs in infan ... | 2016 | 27242976 |
| mirna expression profiling of epstein-barr virus-associated nktl cell lines by illumina deep sequencing. | the aim of this work was to establish the microrna profile of snk6 and snt16, two epstein-barr virus (ebv)-infected cell lines derived from nasal nk/t-cell lymphoma (nktl). the oncogenic ebv is strongly associated with the pathogenesis of nasal and extranodal nk/t-cell lymphoma and expresses 44 mature micrornas and two noncoding ebv-encoded rnas (ebers). mirnas are 19-25nt noncoding rnas that affect host and viral gene expression post-transcriptionally. deregulated mirna patterns are frequently ... | 2016 | 27239439 |
| human herpesvirus type 8-associated large b-cell lymphoma: a nonserous extracavitary variant of primary effusion lymphoma in an hiv-infected man: a case report and review of the literature. | primary effusion lymphoma (pel) is a rare non-hodgkin lymphoma subtype primarily seen in human immunodeficiency virus (hiv)-infected individuals with low cd4(+) cell counts and elevated hiv viral loads. it has always been associated with human herpesvirus type 8 (hhv-8) and in 80% of cases has also been associated with epstein-barr virus (ebv). less commonly, pel has presented in patients with advanced age and other conditions associated with an altered immunity, including malignancy, liver cirr ... | 2016 | 27234438 |
| emerging molecular classifications and therapeutic implications for gastric cancer. | gastric cancer (gc) is a highly aggressive and life-threatening malignancy. even with radical surgical removal and front-line chemotherapy, more than half of gcs locally relapse and metastasize at a distant site. the dismal outcomes reflect the ineffectiveness of a one-size-fits-all approach for a highly heterogeneous disease with diverse etiological causes and complex molecular underpinnings. the recent comprehensive genomic and molecular profiling has led to our deepened understanding of gc. t ... | 2016 | 27233623 |
| epstein-barr virus and carcinomas: rare association of the virus with gastric adenocarcinomas. | 2016 | 27228295 | |
| unusual indolent course of a chronic active epstein-barr virus-associated natural killer cell lymphoproliferative disorder. | natural killer (nk) cell lymphoproliferative disorders are uncommon and the epstein-barr virus (ebv) plays an important aetiological role in their pathogenesis. we report a 20-year-old male with a chronic active ebv infection associated with a nk cell lymphoproliferative disorder which had an unusual indolent course. he presented to the sultan qaboos university hospital in muscat, oman, in december 2011 with a history of intermittent fever and coughing. examinations revealed generalised lymphade ... | 2016 | 27226916 |
| association of atopic diseases and parvovirus b19 with acute lymphoblastic leukemia in childhood and adolescence in the northeast of brazil. | several factors related to the immune system, such as a history of allergies and virus infections, may be associated with acute lymphoblastic leukemia (all). the purpose of this study was to analyze whether the presence of atopic diseases and previous infection with parvovirus b19 and epstein-barr virus (ebv) are associated with the development of all. | 2016 | 27225490 |
| nf-κb deregulation in hodgkin lymphoma. | hodgkin and reed/sternberg (hrs) cells in classical hodgkin lymphoma (hl) show constitutive activity of both the canonical and non-canonical nf-κb signaling pathways. the central pathogenetic role of this activity is indicated from studies with hl cell lines, which undergo apoptosis upon nf-κb inhibition. multiple factors contribute to the strong nf-κb activity of hrs cells. this includes interaction with other cells in the lymphoma microenvironment through cd30, cd40, bcma and other receptors, ... | 2016 | 27221964 |
| epstein-barr virus-positive diffuse large b-cell lymphoma: is it different between over and under 50 years of age? | epstein-barr virus (ebv) positive diffuse large b-cell lymphoma (dlbcl) of the elderly is an entity introduced in the latest who classification of lymphoid tumors and defined in patients older than 50 years without prior lymphoma or immunodeficiency. however, recently it has also been seen in patients under 50. there is thus debate as to whether these are separate entities. | 2016 | 27221931 |
| biomarkers of ebv-positive gastric cancers: loss of pten expression is associated with poor prognosis and nodal metastasis. | epstein-barr virus-positive gastric carcinoma (ebvgc) constitutes approximately 10 % of all gastric carcinoma cases. while distinct molecular features have been characterized previously, there have not been studies identifying their clinical utility. the purpose of this study was to investigate the immunohistochemistry (ihc) profile of ebvgc and to evaluate the potential clinicopathologic and prognostic significance of each marker. | 2016 | 27221363 |
| epstein-barr virus-associated leukemic lymphoma after allogeneic stem cell transplantation. | leukemic epstein-barr virus (ebv)-associated post-transplant lymphoproliferative diseases (ptld) following allogeneic hematopoietic stem cell transplantation are extremely rare. we can successfully treat an ebv-associated leukemic lymphoma patient with rituximab, cidofovir, and donor lymphocyte infusion (dli). in the present case, ebv-specific t cells that were present in the peripheral blood before rituximab administration treatment rapidly increased after dli in association with a decrease in ... | 2016 | 27218416 |
| human serum antibodies against ebv latent membrane protein 1 cross-react with α-synuclein. | to identify the epitope on α-synuclein (α-syn) to which antibodies against the epstein-barr virus (ebv) latent membrane protein 1 (lmp1) bind and to determine whether antibodies targeting this mimicry domain are present in human sera. | 2016 | 27218119 |
| epstein-barr virus nuclear protein ebna3c directly induces expression of aid and somatic mutations in b cells. | activation-induced cytidine deaminase (aid), the enzyme responsible for induction of sequence variation in immunoglobulins (igs) during the process of somatic hypermutation (shm) and also ig class switching, can have a potent mutator phenotype in the development of lymphoma. using various epstein-barr virus (ebv) recombinants, we provide definitive evidence that the viral nuclear protein ebna3c is essential in ebv-infected primary b cells for the induction of aid mrna and protein. using lymphobl ... | 2016 | 27217538 |
| antibodies against epstein-barr virus glycoprotein gp42 for the diagnosis of nasopharyngeal carcinoma. | assessment of immunoglobulin a (iga) antibody responses to epstein-barr virus (ebv) antigen is important for the early diagnosis of nasopharyngeal carcinoma (npc). ebv glycoprotein gp42 has been shown to play an essential role in membrane fusion with b cells. the aim of the present study was to assess whether the antibodies to ebv glycoprotein gp42 in serum could be a novel marker for diagnosis of npc. | 2016 | 27215073 |
| epstein-barr virus infection of mammary epithelial cells promotes malignant transformation. | whether the human tumor virus, epstein-barr virus (ebv), promotes breast cancer remains controversial and a potential mechanism has remained elusive. here we show that ebv can infect primary mammary epithelial cells (mecs) that express the receptor cd21. ebv infection leads to the expansion of early mec progenitor cells with a stem cell phenotype, activates met signaling and enforces a differentiation block. when mecs were implanted as xenografts, ebv infection cooperated with activated ras and ... | 2016 | 27333046 |
| comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy. | gastric cancer (gc) is a leading cause of death. we aim to establish a clinically relevant assay that encompasses recent molecular classifications and provides useful clinical information in a large cohort of gc patients. a consecutive series of 438 gc patients that underwent palliative chemotherapy between 2014 and 2015 were assessed using 10 gc panels: eber in-situ hybridization, immunohistochemistry for mismatch repair (mmr) proteins (mlh1, pms2, msh2, and msh6), receptor tyrosine kinases (rt ... | 2016 | 27331626 |
| integrity of genome-wide genotype data from low passage lymphoblastoid cell lines. | we compared genotype data from the humanexomecore array in peripheral blood mononuclear cells and low passage lymphoblastoid cell lines from the same 24 individuals to test for genotypic errors caused by the epstein-barr virus transformation process. genotype concordance across the 24 comparisons was 99.57% for unfiltered genotype data, and 99.63% following standard genotype quality control filters. mendelian error rates and levels of heterozygosity were not significantly different between lymph ... | 2016 | 27330997 |
| clinical utility of thallium-201 single photon emission computed tomography and cerebrospinal fluid epstein-barr virus detection using polymerase chain reaction in the diagnosis of aids-related primary central nervous system lymphoma. | to determine the diagnostic efficiency of thallium-201 single photon emission computed tomography (spect) and epstein-barr virus (ebv) polymerase chain reaction (pcr) in the differentiation of primary central nervous system lymphoma (pcnsl) from other central nervous system processes in patients with hiv/aids. | 2016 | 27330874 |
| esophageal metastasis secondary to extranodal nasal-type natural killer/t-cell lymphoma: a case report. | we herein report a case of recurrent nasal natural killer (nk)/t-cell lymphoma in a 21-year-old male patient. the patient presented with an esophageal mass, fever and difficulty in swallowing. there were no other obvious sites of recurrence apart from the esophageal lesion. metastatic esophageal lesions are extremely rare. the histological analysis demonstrated a highly aggressive tumor with a characteristic angiodestructive growth pattern and nasal cavity necrosis. the lymphoma cells were immun ... | 2016 | 27330799 |
| clinical association of baseline levels of conjugated dienes in low-density lipoprotein and nitric oxide with aggressive b-cell non-hodgkin lymphoma and their relationship with immunoglobulins and th1-to-th2 ratio. | the aim of this study was to highlight the clinical association of baseline levels of conjugated dienes in low-density lipoprotein (ldl-bcd) and nitric oxide (no) with immunoglobulins (igs) and t helper (th)1/th2 ratio in patients with newly diagnosed b-cell non-hodgkin lymphoma (nhl). | 2016 | 27330333 |
| elevated plasma fibrinogen level shows superior prognostic value than epstein-barr virus dna load for stage iva/b nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era. | effective prognostic factors for patients with stage iva/b nasopharyngeal carcinoma (npc) who are susceptible to distant metastases are limited. we aim to investigate the prognostic value of pretreatment plasma fibrinogen (fib) level and epstein-barr virus dna (ebv-dna) load in these patients in the era of intensity-modulated radiotherapy (imrt). | 2016 | 27323828 |
| embelin prevents lmp1-induced trail resistance via inhibition of xiap in nasopharyngeal carcinoma cells. | the tumor necrosis factor-related apoptosis-inducing ligand (trail) selectively induces apoptosis in the majority of tumor cells, whilst sparing normal cells. however, the potential use of trail in the treatment of cancer is limited by the inevitable emergence of drug resistance. the present study reports the upregulation of latent membrane protein 1 (lmp1)-induced trail resistance via the enhanced expression of x-linked inhibitor of apoptosis protein (xiap) in nasopharyngeal carcinoma (npc) cel ... | 2016 | 27313761 |
| automated quantification of epstein-barr virus in whole blood of hematopoietic stem cell transplant patients using the abbott m2000 system. | accurate quantification of epstein-barr virus (ebv) load in blood is essential for the management of post-transplant lymphoproliferative disorders. the automation of dna extraction and amplification may improve accuracy and reproducibility. we evaluated the ebv pcr kit v1 with fully automated dna extraction and amplification on the m2000 system (abbott assay). | 2016 | 27312691 |
| viruses, anti-viral therapy, and viral vaccines in children with immune thrombocytopenia. | immune thrombocytopenia (itp) might be preceded by silent or overt viral infections. similarly, anti-viral drugs and viral vaccines could also trigger itp and might play a central role in its pathogenesis. the seasonal nature of childhood itp suggests that viral infections might initiate immune responses that increase the predisposition and occurrence of itp. active cytomegalovirus or epstein-barr virus should be considered in differential diagnosis when thrombocytopenia is associated with lymph ... | 2016 | 27312173 |
| peripheral t-cell lymphomas of follicular helper t-cell type frequently display an aberrant cd3(-/dim)cd4(+) population by flow cytometry: an important clue to the diagnosis of a hodgkin lymphoma mimic. | nodal follicular helper t-cell-derived lymphoproliferations (specifically the less common peripheral t-cell lymphomas of follicular type) exhibit a spectrum of histologic features that may mimic reactive hyperplasia or hodgkin lymphoma. even though angioimmunoblastic t-cell lymphoma and peripheral t-cell lymphoma of follicular type share a common biologic origin from follicular helper t-cells and their morphology has been well characterized, flow cytometry of peripheral t-cell lymphomas of folli ... | 2016 | 27312067 |
| cytomegalovirus and langerhans cell histiocytosis: is there a link? | langerhans cell histiocytosis is a rare proliferative histiocytic disease of unknown etiology. histologically, it is characterized by granuloma-like proliferation of langerhans-type dendritic cells derived from bone marrow. many investigators have suggested the possible role of viruses such as epstein-barr virus, human herpesvirus-6 (hhv-6), herpes simplex virus (hsv) types 1 and 2, and cytomegalovirus in the pathogenesis of langerhans cell histiocytosis. | 2016 | 27307972 |
| latency-associated nuclear antigen e3 ubiquitin ligase activity impacts gammaherpesvirus-driven germinal center b cell proliferation. | viruses have evolved mechanisms to hijack components of cellular e3 ubiquitin ligases, thus modulating the ubiquitination pathway. however, the biological relevance of such mechanisms for viral pathogenesis in vivo remains largely unknown. here, we utilized murid herpesvirus 4 (muhv-4) infection of mice as a model system to address the role of muhv-4 latency-associated nuclear antigen (mlana) e3 ligase activity in gammaherpesvirus latent infection. we show that specific mutations in the mlana so ... | 2016 | 27307564 |
| systemic lupus erythematosus. | systemic lupus erythematosus (sle) is an autoimmune disease that can affect many organs, including the skin, joints, the central nervous system and the kidneys. women of childbearing age and certain racial groups are typically predisposed to developing the condition. rare, inherited, single-gene complement deficiencies are strongly associated with sle, but the disease is inherited in a polygenic manner in most patients. genetic interactions with environmental factors, particularly uv light expos ... | 2016 | 27306639 |
| [regulation and evasion of host immune responses by epstein-barr virus]. | epstein-barr virus (ebv) is the first identified human oncogenic dna virus in the gamma-herpesvirus family. ebv triggers a cascade events of innate immune responses through toll-like receptor signaling including the production of type i interferons and the activation of functional autophagy. however, ebv has developed much more elaborate and sophisticated strategies for subverting and escaping the host immune system, such as limiting its own gene expression, activing the host ubiquitin-specific ... | 2016 | 27305776 |
| chromatin remodeling factor lsh drives cancer progression by suppressing the activity of fumarate hydratase. | chromatin modification is pivotal to the epithelial-mesenchymal transition (emt), which confers potent metastatic potential to cancer cells. here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (lsh) in nasopharyngeal carcinoma (npc), a prevalent cancer in china. lsh expression was increased in npc, where it was controlled by the epstein-barr virus-encoded protein lmp1. in npc cells in vitro and in vivo, lsh promoted cancer progression in part by regulating expre ... | 2016 | 27302170 |
| low density of cd204-positive m2-type tumor-associated macrophages in epstein-barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis. | recent studies suggest that cd204-positive (cd204(+)) m2-type tumor-associated macrophages (tams) are associated with the aggressive behavior of various cancers. however, the clinicopathologic significance of tumor-infiltrating cd204(+) macrophages and their correlation with epstein-barr virus (ebv) in gastric cancer is unclear. tissue microarrays were constructed from 119 surgically resected gastric cancer specimens (86 ebv-negative and 28 ebv-positive cases). after immunohistochemistry of cd20 ... | 2016 | 27342912 |
| immunohistochemistry as a surrogate for molecular subtyping of gastric adenocarcinoma. | the cancer genome atlas research network recently classified gastric adenocarcinoma into 4 molecular subtypes: epstein-barr virus-positive tumors, microsatellite-unstable tumors, tumors with chromosomal instability, and genomically stable tumors. we theorized that immunohistochemistry might be useful in similar categorization and that that her2 expression might relate to subtype. we stained 104 gastric adenocarcinomas for mlh1, p53, and eber in situ hybridization. we grouped them based on staini ... | 2016 | 27342907 |
| physical activity, sedentary behaviors, and epstein-barr virus antibodies in young adults. | this study aimed to elucidate the associations between physical activity, sedentary behaviors, and epstein-barr virus (ebv) antibody levels (as an indirect marker of cell-mediated immunity, cmi). this study made use of a 14-year longitudinal study with a representative sample of adolescents in the us. a total of 3361 participants (42.1% male) aged 11 to 21years at baseline who completed wave i (1994-1995), wave iii (2001-2002), and wave iv (2008) surveys of the national longitudinal study of ado ... | 2016 | 27342426 |
| epstein-barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. | epstein-barr virus (ebv)-associated smooth muscle tumors (smts) have recently been associated with primary and secondary immunodeficiencies. they are broadly divided into 3 subgroups: hiv-related, posttransplant, and congenital immunodeficiency. subsequent to organ transplantation and acquired immunosuppression, a few cases of ebv-associated smts have been described in the liver, respiratory tract, and gastrointestinal system. to the authors' knowledge, intracranial involvement after peripheral ... | 2016 | 27341041 |
| regulation of ebv lmp1-triggered epha4 downregulation in ebv-associated b lymphoma and its impact on patients' survival. | epstein-barr virus (ebv), an oncogenic human virus, is associated with several lymphoproliferative disorders, including burkitt lymphoma, hodgkin disease, diffuse large b-cell lymphoma (dlbcl), and posttransplant lymphoproliferative disorder (ptld). in vitro, ebv transforms primary b cells into lymphoblastoid cell lines (lcls). recently, several studies have shown that receptor tyrosine kinases (rtks) play important roles in ebv-associated neoplasia. however, details of the involvement of rtks i ... | 2016 | 27338098 |
| validation of an optimized elisa for quantitative assessment of epstein-barr virus antibodies from dried blood spots. | our objective was to validate a commercially available elisa to measure antibody titers against epstein-barr virus (ebv) in dried blood spots (dbs) to replace a previously validated assay for dbs that is no longer available. we evaluated the precision, reliability, and stability of the assay for the measurement of ebv antibodies in matched plasma, fingerprick dbs, and venous blood dbs samples from 208 individuals. effects of hematocrit and dbs sample matrix on ebv antibody determination were als ... | 2016 | 27337556 |
| epstein-barr virus. | this review covers relevant clinical and laboratory information relating to epstein-barr virus (ebv) infections in immunocompromised hosts. it describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. the review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the ebv load in peripheral blood, identifying both strengths ... | 2016 | 27337443 |
| standardised incidence ratios (sirs) for cancer after renal transplant in systemic lupus erythematosus (sle) and non-sle recipients. | we investigated malignancy risk after renal transplantation in patients with and without systemic lupus erythematosus (sle). | 2016 | 27335659 |
| bzlf1 attenuates transmission of inflammatory paracrine senescence in epstein-barr virus-infected cells by downregulating tumor necrosis factor alpha. | recent studies have shown that inflammatory responses trigger and transmit senescence to neighboring cells and activate the senescence-associated secretory phenotype (sasp). latent epstein-barr virus (ebv) infection induces increased secretion of several inflammatory factors, whereas lytic infections evade the antiviral inflammatory response. however, the changes in and roles of the inflammatory microenvironment during the switch between ebv life cycles remain unknown. in the present study, we d ... | 2016 | 27334596 |
| loss of arid1a expression predicts poor survival prognosis in gastric cancer: a systematic meta-analysis from 14 studies. | the chromatin remodeling gene, at-rich interactive domain 1a gene (arid1a), frequently mutates inactively in gastric cancer (gc). however, its prognostic value remains controversial. to address this issue, a comprehensive meta-analysis was performed. studies published until march 2016 were systematically searched. a total of 15 cohorts from 14 literatures involving 3183 patients were subjected to this meta-analysis. the pooled data showed that arid1a expression loss predicted poor overall surviv ... | 2016 | 27354232 |
| response to 5-azacytidine in a patient with tet2-mutated angioimmunoblastic t-cell lymphoma and chronic myelomonocytic leukaemia preceded by an ebv-positive large b-cell lymphoma. | we report the case of a patient with a history of epstein-barr virus-positive large b-cell lymphoma, who relapsed with an angioimmunoblastic t-cell lymphoma (aitl) associated with a chronic myelomonocytic leukaemia (cmml). we performed targeted next-generation sequencing on cmml and aitl dna, which revealed mutations of tet2, dnmt3a, srsf2, nras and idh1, thus confirming that the spectrum of aitl mutations share similarities with myeloid disorders. the frequencies of tet2/dnmt3a and srsf2 varian ... | 2016 | 27353473 |
| three rwandan children with massive splenomegaly and epstein-barr virus-associated lymphoproliferative disorders: case presentations and the literature review. | this report describes 3 rwandan children with massive splenomegaly and pancytopenia who underwent splenectomy. each was diagnosed with epstein-barr virus-associated lymphoproliferative disorder (ebv lpd) based on lymphocyte morphology, lymphocyte immunophenotype, and the results of ebv in situ hybridization studies. the differential diagnosis of splenomegaly, with a special emphasis on the sub-saharan african context, is discussed along with ebv and associated disorders. these cases serve as a c ... | 2016 | 27352192 |
| a fully human igg1 anti-pd-l1 mab in an in vitro assay enhances antigen-specific t-cell responses. | monoclonal antibodies (mabs) that interfere with checkpoint molecules are being investigated for the treatment of infectious diseases and cancer, with the aim of enhancing the function of an impaired immune system. avelumab (msb0010718c) is a fully human igg1 mab targeting programmed death-ligand 1 (pd-l1), which differs from other checkpoint-blocking antibodies in its ability to mediate antibody-dependent cell-mediated cytotoxicity. these studies were conducted to define whether avelumab could ... | 2016 | 27350882 |
| epstein-barr virus dynamics in asymptomatic immunocompetent adults: an intensive 6-month study. | characterizing epstein-barr virus (ebv) dynamics in asymptomatic immunocompetent persons provides a baseline for defining quantitative thresholds associated with ebv disease. studying latent membrane protein (lmp)-1 sequence variation over time could establish the rates of reactivation and superinfection, and also trace transmission. twelve asymptomatic adult subjects were evaluated prospectively nine times over 6 months. ebv serum antibodies were measured by enzyme immunoassay. ebv dna in oral ... | 2016 | 27350880 |
| successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients. | although gastroduodenal ulcers are common in solid organ transplant patients, there are few reports on multiple giant ulcers in the distal ileum and ileocecal valve caused by immunosuppressants herein, we report on a liver transplant recipient and a renal transplant recipient with multiple large ulcers in the distal ileum and ileocecal valve who rapidly achieved ulcer healing upon withdrawal of sirolimus or tacrolimus and administration of thalidomide. in case 1, a 56-year-old man with primary h ... | 2016 | 27350740 |
| an epstein-barr virus-encoded protein complex requires an origin of lytic replication in cis to mediate late gene transcription. | epstein-barr virus lytic replication is accomplished by an intricate cascade of gene expression that integrates viral dna replication and structural protein synthesis. most genes encoding structural proteins exhibit "true" late kinetics-their expression is strictly dependent on lytic dna replication. recently, the ebv bcrf1 gene was reported to encode a tata box binding protein homolog, which preferentially recognizes the tatt sequence found in true late gene promoters. bcrf1 is one of seven ebv ... | 2016 | 27348612 |
| diagnosis and management of extranodal nk/t cell lymphoma nasal type. | extranodal nk/t-cell lymphoma nasal type is a distinct clinicopathologic entity. the most common initial site of presentation is the nasopharyngeal area, but non-nasals sites including the skin and the gastrointestinal tract may be affected. | 2016 | 27347812 |
| serum baff levels, methypredsinolone therapy, epstein-barr virus and mycobacterium avium subsp. paratuberculosis infection in multiple sclerosis patients. | elevated b lymphocyte activating factor baff levels have been reported in multiple sclerosis (ms) patients; moreover, disease-modifying treatments (dmt) have shown to influence blood baff levels in ms patients, although the significance of these changes is still controversial. in addition, baff levels were reported increased during infectious diseases. in our study, we wanted to investigate on the serum baff concentrations correlated to the antibody response against mycobacterium avium subspecie ... | 2016 | 27383531 |
| esophageal and gastric ulceration due to synchronous herpes simplex virus, cytomegalovirus and epstein-barr virus infection. | 2016 | 27382954 | |
| targeting the ca(2+) sensor stim1 by exosomal transfer of ebv-mir-bart13-3p is associated with sjögren's syndrome. | primary sjögren's syndrome (pss) is a systemic autoimmune disease that is associated with inflammation and dysfunction of salivary and lacrimal glands. the molecular mechanism(s) underlying this exocrinopathy is not known, although the syndrome has been associated with viruses, such as the epstein barr virus (ebv). we report herein that an ebv-specific microrna (ebv-mir-bart13-3p) is significantly elevated in salivary glands (sgs) of pss patients and we show that it targets stromal interacting m ... | 2016 | 27381477 |
| changing patterns in the epstein-barr virus (ebv)and hodgkin lymphoma association in tunisia. | we compared the features of the epstein-barr virus (ebv) and hodgkin lymphoma (hl) association in tunisia in two periods of time, 1991-2001 (111 cases) and 2002-2012 (122 cases). the investigation of the ebv status by eber in situ hybridization showed a significant decrease in the prevalence of ebv-positive hl from 69.3 % for the period 1991-2001 to 40.1 % for the 2002-2012 period (p = 0.00001). ebv positivity has decreased in all age groups but was more pronounced among young patients, in the 1 ... | 2016 | 27378019 |
| classical hodgkin lymphoma with positive epstein-barr virus status is associated with more foxp3 regulatory t cells. | background classical hodgkin lymphoma (chl) is characterized by sparse malignant hodgkin and reed-sternberg cells dispersed in an inflammatory microenvironment. immune evasion of malignant cells is partially due to the existence of a subpopulation of immunosuppressive regulatory t cells (treg). the aim of this study was to analyze t cell composition in chl with special emphasis on treg in regard to epstein-barr virus (ebv) status, subtype, and patient age. material and methods the study included ... | 2016 | 27377121 |
| late persistent positive ebv viral load and risk of solid cancer in kidney transplant patients. | recent studies reported that posttransplant epstein-barr virus (ebv) replication is frequent and indicates overimmunosuppression. we hypothesized that long-term ebv replication may identify overimmunosuppressed patients at higher risk of cancer. | 2016 | 27367471 |
| prognostic significance of signal transducer and activator of transcription 5 and 5b expression in epstein-barr virus-positive patients with chronic lymphocytic leukemia. | signal transducer and activator of transcription (stat) proteins have been intensively studied in hematologic malignancies, and the efficacy of agents against stats in lymphomas is already under research. we investigated the expression of total stat5 and stat5b in peripheral blood samples of patients with chronic lymphocytic leukemia (cll) in correlation with the presence of epstein-barr virus (ebv) and its major oncoprotein (latent membrane protein 1, lmp1). the ebv load was measured in the per ... | 2016 | 27367207 |
| evaluation of the risk of lymphomagenesis in xenografts by the pcr-based detection of ebv bamhi w region in patient cancer specimens. | establishment of patient-derived tumor xenografts (pdxs) is hampered by lymphomagenesis mostly caused by the latently-infected epstein-barr virus (ebv) contained in patient cancer tissues. however, the character of patient tissues that result in lymphomagenesis after xenotransplantation is not elucidated. in this study, we analyzed the patient colorectal cancer (crc) tissues and the pdxs established by their xenotransplantation. we found that 2 of 9 (22%) pdx tumors were ebv-associated human dif ... | 2016 | 27367028 |
| management of epstein-barr virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: sixth european conference on infections in leukemia (ecil-6) guidelines. | epstein-barr virus-related post-transplant lymphoproliferative disorders are recognized as a significant cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation. to better define current understanding of post-transplant lymphoproliferative disorders in stem cell transplant patients, and to improve its diagnosis and management, a working group of the sixth european conference on infections in leukemia 2015 reviewed the literature, graded the available quali ... | 2016 | 27365460 |
| recurrence of tubulointerstitial nephritis without uveitis, in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. | we report a case of recurrent tubulointerstitial nephritis without uveitis in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. a 26-year-old male patient who had been diagnosed with tubulointerstitial nephritis and uveitis syndrome at 8 years of age developed end-stage renal failure and subsequently underwent living-donor related renal transplant at 17 years old. the 1st recurrence of tubulointerstitial nephritis and uveitis occurred 36 months after tra ... | 2016 | 27364115 |
| epstein-barr virus-associated smooth muscle tumor. | immunodeficient individuals are prone to develop a number of opportunistic infections and unique neoplasms. epstein-barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. it has been described in patients infected with human immunodeficiency virus, in the posttransplant setting, and in those with congenital immunodeficiency. different anatomic sites can be involved by epstein-barr virus-associated smooth muscle tumor, and even multiple locations can c ... | 2016 | 27362573 |
| association of epstein-barr virus (ebv) but not human papillomavirus (hpv) with gingivitis and/or periodontitis in transplanted individuals. | the aim of this study was to investigate the association of ebv and hpv with gingivitis and/or periodontitis according to the immunologic status. to this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by pcr for both viruses. according to the results, ebv was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.011) but not hpv (p = 0.766). ebv-hpv co-detecti ... | 2016 | 27410918 |
| global transcript structure resolution of high gene density genomes through multi-platform data integration. | annotation of herpesvirus genomes has traditionally been undertaken through the detection of open reading frames and other genomic motifs, supplemented with sequencing of individual cdnas. second generation sequencing and high-density microarray studies have revealed vastly greater herpesvirus transcriptome complexity than is captured by existing annotation. the pervasive nature of overlapping transcription throughout herpesvirus genomes, however, poses substantial problems in resolving transcri ... | 2016 | 27407110 |
| the value of circulating cyfra21-1 expression in patients with nasopharyngeal carcinoma: a study of 529 subjects. | early diagnosis of nasopharyngeal carcinoma (npc) needs more reliable biomarkers. the aim of this study was to investigate serum cytokeratin 19 fragment 21.1 (cyfra21-1) as an npc biomarker based on data from a large sample. | 2016 | 27405513 |
| follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of mdm2, somatostatin receptor 2a, and pd-l1. | follicular dendritic cell sarcoma (fdcs) is a rare low-grade neoplasm with the phenotype of fdc cells. this rare sarcoma has been well known for being mistaken for a variety of neoplasms (mainly meningioma), particularly at extranodal sites. diagnosis of fdcs mainly relies on characteristic histologic appearance supplemented by immunohistochemistry and electron microscopy. in this study, we reviewed 15 fdcss retrieved from our consultation files and stained them for newly reported or novel marke ... | 2016 | 27402219 |
| biological and molecular characterization of a rare case of cutaneous richter syndrome. | richter syndrome (rs) is the transformation of chronic lymphocytic leukemia in a high-grade lymphoma usually presenting nodal and bone marrow involvement. richter syndrome can be localized at extranodal sites including the gastrointestinal tract, lungs, and skin. cutaneous rs is an extremely rare disease apparently showing a less aggressive course than common presentations. while nodal rs has been extensively investigated in literature, pathogenesis and prognosis of cutaneous rs are still partia ... | 2016 | 27400669 |
| interleukin (il)-39 [il-23p19/epstein-barr virus-induced 3 (ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. | interleukin (il)-12 family cytokines play critical roles in autoimmune diseases. our previous study has shown that il-23p19 and epstein-barr virus-induced 3 (ebi3) form a new il-12 family heterodimer, il-23p19/ebi3, termed il-39, and knock-down of p19 or ebi3 reduced diseases by transferred gl7(+) b cells in lupus-prone mice. in the present study, we explore further the possible effect of il-39 on murine lupus. we found that il-39 in vitro and in vivo induces differentiation and/or expansion of ... | 2016 | 27400195 |
| a nomogram for predicting survival of nasopharyngeal carcinoma patients with metachronous metastasis. | patients with metachronous metastatic nasopharyngeal carcinoma (npc) differ significantly in survival outcomes. the aim of this study is to build a clinically practical nomogram incorporating known tumor prognostic factors to predict survival for metastatic npc patients in epidemic areas.a total of 860 patients with metachronous metastatic nasopharyngeal carcinoma were analyzed retrospectively. variables assessed were age, gender, body mass index, karnofsky performance status (kps), union for in ... | 2016 | 27399084 |
| increased epstein-barr virus in breast milk occurs with subclinical mastitis and hiv shedding. | epstein-barr virus (ebv) in breast milk and subclinical mastitis (scm) are both associated with human immunodeficiency virus (hiv) shedding and possibly with postnatal hiv transmission. the objective of this nested case-control study was to investigate the interplay between scm and ebv replication in breast milk of hiv-infected mothers.the relationships between ebv deoxyribonucleic acid (dna) shedding, hiv-1 ribonucleic acid (rna) level, and scm were explored in breast milk samples of zambian mo ... | 2016 | 27399077 |
| the effect of self-reported health on latent herpesvirus reactivation and inflammation in an ethnically diverse sample. | self-rated health (srh) is a reliable predictor of health outcomes including morbidity and mortality. immune dysregulation is one hypothesized mechanism underlying the association between srh and health outcomes. indeed, poorer srh is associated with greater inflammation. the association between srh and reactivation of latent herpesviruses is unknown, representing an important gap in the literature given that reactivation of latent herpesviruses leads to enhanced inflammation. the present study ... | 2016 | 27398881 |
| fine specificity of the antibody response to epstein-barr nuclear antigen-2 and other epstein-barr virus proteins in patients with clinically isolated syndrome: a peptide microarray-based case-control study. | we analyzed the fine specificity of antibodies to epstein-barr nuclear antigen-2 (ebna-2) and other epstein-barr virus (ebv) proteins in 29 patients with clinically isolated syndrome (cis, the first clinical manifestation of multiple sclerosis [ms]) and 29 controls with a peptide microarray containing 117 overlapping peptides representing the full-length ebna-2 protein and 71 peptides from 8 further ebv proteins. while ebv peptide antibodies were elevated in cis, suggesting that ebv contributes ... | 2016 | 27397076 |
| [research advances in target genes of epstein-barr virus-encoded micrornas]. | the epstein-barr virus (ebv) is a gamma herpes virus associated with several types of malignancies. the ebv encodes viral micrornas (mirnas) that can target genes within cells. the ebv participates in signal transduction as well as the proliferation and differentiation of cells. how the target genes and functions of ebv-encoded mirnas contribute to the pathogenesis of ebv is an important research topic. some target genes have been validated since ebv-encoded mirnas were discovered and, in this a ... | 2016 | 27396169 |
| cytotoxic effects of nf‑κb inhibitors in combination with anti‑herpes agents on epstein‑barr virus‑positive gastric carcinoma in vitro. | epstein-barr virus (ebv) infection in tumor cells is usually restricted to the latent form, indicating that the induction of viral lytic infection may present a novel approach for the treatment of ebv‑associated tumors. by contrast, ebv lytic replication is inhibited by high‑levels of nuclear factor (nf)‑κb, which suggests that nf‑κb inhibitors may activate lytic replication from the latent form. in the current study, the addition of nf‑κb inhibitors (bay11‑7082, z‑llf‑cho and aspirin) was obser ... | 2016 | 27430429 |
| axonal polyneuropathy as an unusual manifestation of acute epstein-barr virus infection in an adult. | 2016 | 27430089 |