Publications

lyme disease--united states, 1987 and 1988.		1989	2506418
scintigraphic evaluation of lyme disease: gallium-67 imaging of lyme myositis.	a patient suffering from lyme disease had cardiac conduction abnormalities, symptoms of arthritis, and myalgia. a ga-67 image showed evidence of endomyocarditis, but intense skeletal muscle uptake pointed to lyme myositis. reference is made to two other case reports of lyme myositis.	1989	2805522
clinical aspects of lyme disease.		1989	2794810
lyme disease--the great imitator.		1989	2794806
triple-phase bone image abnormalities in lyme arthritis.	arthritis is a frequent manifestation of lyme disease. limited triple-phase tc-99m mdp bone imaging of the wrists and hands with delayed whole-body images was performed in a patient with lyme arthritis. this demonstrated abnormal joint uptake in the wrists and hands in all three phases, with increased activity seen in other affected joints on delayed whole-body images. these findings are nonspecific and have been previously described in a variety of rheumatologic conditions, but not in lyme dise ...	1989	2509122
lyme disease facial palsy: differentiation from bell's palsy.		1989	2508822
lyme disease in rhode island.		1989	2587914
lyme disease.	within the last decade, lyme borreliosis has emerged as a complex new infection whose distribution is worldwide. the disorder is caused by a recently recognized spirochete, b. burgdorferi, transmitted by ticks of the i. ricinus complex. certain species of mice are critical in the life cycle of the spirochete, and deer appear to be crucial to the tick. although the disorder's basic outlines are similar everywhere, there are regional variations in the causative spirochete, animal hosts, and clinic ...	1989	2668764
[limb and joint pain in lyme disease. an important differential neurologic diagnosis].	on the basis of 4 cases, attention is drawn to the problem of early detection of lyme disease. the occurrence of joint pain with fluctuating spread and unresponsive to the usual antiinflammatory therapy should prompt the physician to consider lyme disease, which can be confirmed or excluded only by lumbar puncture. the csf shows a cell count of between 300/3 and 2,000/3 cells (90% lymphocytes) and usually moderately elevated protein. a demonstration of elevated antibody titers confirms the diagn ...	1989	2767602
unusual neurological manifestations of lyme disease: a case report.	we describe a case of lyme disease with a prolonged relapsing-remitting course, in which peripheral facial palsy, optic neuritis and myopathy were associated. after high-dose penicillin therapy the patient completely recovered.	1989	2793420
lyme disease in northern california.		1989	2773475
lyme disease.		1989	2701557
[lyme disease in chile].		1989	2519461
lyme disease in canada--1989 update.		1989	2752449
lyme and other tick-borne diseases acquired in south carolina in 1988: a survey of 1,331 physicians.	2,346 primary care physicians were surveyed by mail to estimate the number of cases of tick-borne fever diagnosed by them during 1988. the results of the 57% response reveal 344 cases of rocky mountain spotted fever, 90 cases of lyme disease and 33 other tick-borne disease cases acquired in south carolina. the implications for a greater level of clinical awareness and a search for endemic vectors and animal hosts are emphasized.	1989	2788233
transient complete av block in lyme disease. electrophysiologic observations.	the findings in a patient with complete av block and intra-atrial conduction disturbances due to lyme disease are presented. the electrocardiographic follow-up and serial ep findings suggest that complete av block in lyme disease may signify a more extensive affection of the av conduction system (with eventually attendant intra-atrial conduction disturbances) than described in earlier reports. an almost complete resolution of the considerable damage to the conduction system occurred within two w ...	1989	2736985
seronegative lyme disease and transitory atrioventricular block.		1989	2735630
lyme disease: an annotated bibliography. national institute of arthritis and musculoskeletal and skin diseases.		1989	2667893
the expanding ophthalmologic spectrum of lyme disease.		1989	2729420
lyme disease in a young girl.	in brief: an 11 1/2-year-old girl had a seven-month history of bilateral knee pain and swelling; her x-rays and bone scan were normal. she had been treated unsuccessfully with rest and physical therapy before being referred to a sports medicine clinic. laboratory studies demonstrated a positive titer for lyme disease. she was treated with tetracycline and had an uneventful recovery.	1989	27447326
lyme disease and antibiotic prophylaxis.		1989	2758829
practicing in lyme disease territory.		1989	2758828
legal implications of uncertainty in lyme disease.		1989	2758826
sharing the task of lyme disease. public education.		1989	2758825
lyme disease and pregnancy.		1989	2758822
a prospective study of tick bites in an endemic area for lyme disease.		1989	2758821
national surveillance of lyme disease, 1987-1988.	in 1987 and 1988, 6876 lyme disease cases from 43 states were reported to the centers for disease control. the 4507 cases reported in 1988 was nearly double the case number reported in 1987, and ninefold the number reported in 1982, when a systematic system of national surveillance was established. the average annual incidence of reported lyme disease in the united states in 1987-1988 was 1.4/100,000. new york led the nation in reported cases in 1988 with 57% of the cases reported nationally. ei ...	1989	2758820
lyme disease.		1989	2758818
ticks, lyme disease, and spotted fever.		1989	2739954
late cutaneous lyme disease: acrodermatitis chronica atrophicans.		1989	2729343
catching the bug: how scientists found the cause of lyme disease and why we're not out of the woods yet.		1989	2667891
lyme disease prevention: personal protection and prospects for tick control.		1989	2667889
treatment of lyme disease.	lyme disease, a tick-transmitted spirochetal infection, can be divided into three stages that can overlap or occur alone. the goals of antibiotic therapy in stage one are to shorten the duration of early disease and to prevent the development of later stages of the illness. this can usually be accomplished with oral antibiotic therapy. later stages of the illness are frequently more difficult to treat, requiring prolonged oral or intravenous antibiotic therapy.	1989	2667887
clinical manifestations of lyme disease in the united states.		1989	2667885
selected tickborne infections. a review of lyme disease, rocky mountain spotted fever, and babesiosis.		1989	2662061
[clinical manifestations of lyme disease].	lyme disease can be divided into three phases; (1) a primary phase where the inconstant erythema migrans predominates; (2) a secondary phase, sometimes revealing the disease, with isolated or associated cutaneous and cardiac signs and articular or neurological manifestations responding to antibiotics, and (3) a tertiary phase with cutaneous, articular and above all neurological signs which are chronic and sometimes severe. a better knowledge of this infection has enabled some rheumatological or ...	1989	2740781
lyme disease: diagnosis by observation.		1989	2743543
lyme disease.		1989	18750537
[facial palsy in lyme disease].	this paper reports twenty four cases of facial palsy in lyme disease for the first time in the forest region. most cases had history of tick bite. two strains of spirochete were isolated from the blood of 7 patients with facial palsy. these spirochetes were immunologically closely related to b. burgdorferi. eighteen serum samples of facial palsy were tested by indirect fluorescence assay, using b. burgdorferi b-31 as antigen. in serum, igg antibody titers of 1:64 to 1:2048 were found in 50% of t ...	1989	2805978
autoreactive t cells in rheumatic disease (1). analysis of growth frequencies and autoreactivity of t cells in patients with rheumatoid arthritis and lyme disease.	a limiting dilution system was established in order to estimate frequencies of interleukin-2 (il-2)-responsive, autoreactive and alloreactive t cells in samples of peripheral blood (pbl) and synovial fluid lymphocytes (sfl), from patients with rheumatoid arthritis (ra) and lyme disease, as well as from healthy donors and a patient with osteoarthrosis. the frequencies of il-2-dependent t-cell colony formation were significantly higher in patients with ra and lyme disease (median: 1/287) as compar ...	1989	2787645
[cardiac manifestations of lyme disease. apropos of a case].	a new case of heart involvement in lyme's disease is reported. its originality lies in its strictly isolated nature, therefore revealing the disease; in its typical picture of myocardopericarditis combining, in various stages, infra-hissian conduction disorders, bouts of left ventricular insufficiency, pseudoischemic repolarisation disorders and finally a moderate pericardial shift; in the demonstration, during two successive heart explorations by nmr (nuclear magnetic resonance), of a diffuse m ...	1989	2650610
lyme disease, 1988: immunologic manifestations and possible immunopathogenetic mechanisms.		1989	2648575
lyme disease.		1989	2522487
the expanding ophthalmologic spectrum of lyme disease.		1989	2912121
lyme disease: a case report.		1989	2926030
is lyme disease a health threat for your students?		1989	2926029
the continuing saga of lyme disease.		1989	2909192
lyme myocarditis diagnosed by indium-111-antimyosin antibody scintigraphy.	we report a new case of lyme disease with cardiac manifestations, which has been possible to follow during the long period of 12 years. we have detected the usual ecg abnormalities, and concentric hypertrophic myocardiopathy, by echocardiography. the acute myocarditis was demonstrated by 111in-antimyosin scintigraphy, which showed global myocardial uptake of the tracer, constituting the first report, to our knowledge, of lyme myocarditis diagnosed by this method.	1989	2767084
neurological manifestations of lyme disease and treatments.	lyme disease is a multi-systemic infection due to b. burgdorferi, with neurological manifestations observed in its second and third stages. except for the suggestive triad meningitis--radiculoneuritis--facial palsies, the diagnosis is often difficult because of the pleiomorphism of neurological manifestations. these can be localized or diffuse, with central involvement, meningitis or peripheral manifestations. past history, cerebrospinal fluid (csf) examination, immuno-assays for specific antibo ...	1989	2686767
a connecticut housewife in francis bacon's court: polly murray and lyme disease.		1989	2682690
[lyme disease].		1989	2658717
lyme disease in children and adolescents.		1989	2650970
lyme disease. a review and case report with pedal symptoms.		1989	2664128
pediatric rehabilitation. 5. joint and connective tissue diseases.	this self-directed learning module presents pertinent information about rehabilitation management of specific joint and connective tissue diseases affecting children. this section highlights juvenile rheumatoid arthritis, lyme disease, rheumatic fever, hemophilia, dermatomyositis, polymyositis, systemic lupus erythematosus, and other forms of arthritis. it is a section of the chapter of pediatric rehabilitation for the self-directed medical knowledge program study guide for practitioners and tra ...	1989	2655558
be ready for lyme disease in your own backyard.		1989	2928693
joint pain in children. when is it serious?	diagnosis of the cause of joint pain in children depends on the physician's ability to distinguish benign from more serious joint conditions. benign conditions include trauma, overuse syndromes, hypermobility syndrome, chondromalacia patellae, benign recurrent limb pains, and psychogenic rheumatism. conditions that require further evaluation and ongoing therapy include lyme disease, rheumatic fever, juvenile rheumatoid arthritis, neoplastic disease, various orthopedic conditions, infection, sero ...	1989	2928285
erythema chronicum migrans as the presenting manifestation of juvenile chronic myelocytic leukemia.	we describe the case of a 3-year-old boy who presented with typical clinical features of lyme disease, including erythema chronicum migrans and arthritis. over subsequent months, however, the clinical picture evolved into juvenile chronic myelocytic leukemia. to our knowledge, the combination of lyme disease and juvenile chronic myelocytic leukemia has not been described. dermatologic and other relevant clinical findings are presented, and the cause and effect relationship between these two rare ...	1989	2731438
surveillance for lyme disease in alabama.	to estimate the frequency of occurrence of lyme disease in alabama, in september 1988 the department of public health requested physicians and laboratories to begin voluntary reporting of cases of lyme disease. thirteen cases, 5 confirmed, 1 probable, 4 presumptive and 3 possible, were reported for the years 1986-1988. counties in which tick exposure likely occurred included calhoun, cleburne, mobile, monroe, shelby, talladega and tallapoosa. lyme disease occurs in alabama but appears to be unco ...	1989	2729028
[lyme disease in the child].		1989	2665685
lyme disease: a review and an outlook for indiana.		1989	2656848
[lyme disease. recurrence of the skin lesion after treatment].		1989	2716391
[meningo-radiculitis in lyme disease resistant to penicillin g].		1989	2523059
eosinophilic lymphadenitis in lyme disease.		1989	2710589
lyme disease.		1989	2661449
lyme carditis: an important cause of reversible heart block.	lyme disease is a tick-borne spirochetal infection, characterized by erythema chronicum migrans and an acute systemic illness. the disease is endemic in many parts of the north-eastern united states. without treatment, late rheumatic, neurologic, and cardiac complications frequently occur. we report four serologically confirmed cases of lyme carditis in previously healthy young men (mean age, 45 years) from endemic areas. each presented with severe symptomatic atrioventricular block, three with ...	1989	2644885
isolation and characterization of borrelia burgdorferi-specific and autoreactive t-cell lines from the cerebrospinal fluid of patients with lyme meningoradiculomyelitis.		1988	2462820
a murine igm monoclonal antibody binds an antigenic determinant in outer surface protein a, an immunodominant basic protein of the lyme disease spirochete.	a hybridoma cell line formed by the fusion of the p3x63-ag8.653 myeloma cell line with splenocytes from balb/c mice immunized with borrelia burgdorferi produced an igm monoclonal antibody (mab-11g1) with kappa-light chains which detected an antigenic determinant in a major spirochetal protein of m.w. approximately 31,000, also known as outer surface protein a (osp-a). apparent saturation was reached in approximately 35 min with 34 ng of mab-11g1 binding to 5 x 10(7) spirochetes giving an estimat ...	1988	2447170
[primary lymphoma of the nervous system following radiculoneuritis caused by borrelia burgdorferi: study of a case].	a 50-year-old man had a primary lymphoma of the central nervous system one year after a tick bite and a radiculoneuritis secondary to borrelia burgdorferi infection. determination of antibodies against borrelia burgdorferi revealed increasing igm and igg titers, and the autopsy showed a primary b-cell immunoblastic lymphoma of the brain without evidence of extraneural lymphoproliferative disorder. lymphoma of the brain is a rare type of central nervous system cancer, and sporadic cases appear wi ...	1988	2451279
biological activity of borrelia burgdorferi antigens.	osp-a (approximately 31 kda) and flagellins (approximately 41 kda) are prominent antigens of borrelia burgdorferi. both osp-a and flagellins are immunogenic in patients and in experimentally infected mice and hamsters, but the kinetics of antibody formation to each vary considerably between the species. the role of eluted osp-a and flagellins in the cellular immune response, chemotaxigenesis, and cytoadherence was measured. eluted osp-a and flagellins stimulated the proliferation of normal and i ...	1988	2461134
antigenic variability of borrelia burgdorferi.	borrelia burgdorferi strains (six isolates from north america and 28 isolates from europe) were analyzed by physicochemical and immunological methods. by sds-page, all borrelia burgdorferi strains tested had two major proteins with constant molecular weights of 60 and 41 kda and one, two, or three variable low molecular weight proteins (ospa = 30-32 kda, ospb = 34-36 kda, pc = 21-22 kda). all combinations--except ospb alone or ospb/pc--were observed. borrelia burgdorferi strains were different f ...	1988	2461135
clinical and serologic evaluations of induced borrelia burgdorferi infection in dogs.	adult beagles were used to evaluate clinical signs and serologic response after inoculation with, or exposure to, borrelia burgdorferi. an indirect immunofluorescent assay (ifa) and 2 elisa were used to monitor the serologic response to b burgdorferi. feeding infected ticks on 4 dogs (group 1) failed to cause seroconversion, and sc inoculation with 500 organisms caused minimal seroconversion in 2 of 4 dogs (group 2). at 56 days, approximately 3.01 x 10(8) b burgdorferi organisms were injected iv ...	1988	3041881
[serodiagnosis of lyme borreliosis].	there are various serodiagnostic tests available for the detection of antibodies against borrelia burgdorferi. an indirect hemagglutination assay, which can detect both igm and igg antibodies, was developed for antibody screening. regarding the confirmation and differentiation of igm and igg, we use the indirect immunofluorescence assay (most specific when performed with sera previously absorbed with treponema phagedenis) as well as the elisa test. the detection of significantly elevated antibod ...	1988	3043955
serodiagnosis of early lyme disease: analysis of igm and igg antibody responses by using an antibody-capture enzyme immunoassay.	we used an antibody-capture enzyme immunoassay (eia) to evaluate the early antibody responses to borrelia burgdorferi in paired sera from 30 patients with erythema chronicum migrans. during acute disease, 20 (67%) patients had elevated specific igm responses, and by convalescence (one to four weeks after treatment), 28 (93%) patients had increased igm or igg responses. in acute specimens, elevated igm responses correlated with disseminated infection; however, by convalescence, most patients with ...	1988	3049839
seronegative lyme disease. dissociation of specific t- and b-lymphocyte responses to borrelia burgdorferi.	the diagnosis of lyme disease often depends on the measurement of serum antibodies to borrelia burgdorferi, the spirochete that causes this disorder. although prompt treatment with antibiotics may abrogate the antibody response to the infection, symptoms persist in some patients. we studied 17 patients who had presented with acute lyme disease and received prompt treatment with oral antibiotics, but in whom chronic lyme disease subsequently developed. although these patients had clinically activ ...	1988	3054554
[lyme disease. clinical, biological and developmental aspects. 29 cases in the orléans region].	the description of lyme's disease (ld) in 3 stages (like syphilis), has now become classical. 29 cases of ld, between june 1981 and november 1986, have been recorded at the hospital in orleans. the first twelve patients that were clinically diagnosed before the serology was introduced in france, have been recalled in order to search for possible late forms and assay their antibody level of anti-borrelia burgdorferi. the preponderance of neurological forms (22 cases) and the scarcity of periphera ...	1988	3055243
modulation of natural killer cell activity by borrelia burgdorferi.		1988	3056196
serologic diagnosis of lyme disease.	indirect fluorescent antibody tests and enzyme-linked immunosorbent assays are being used as laboratory aids for the diagnosis of lyme disease and related disorders. depending on the needs, polyvalent or class-specific reagents can be used to detect total immunoglobulins (ig) or igm and igg antibodies. the sensitivities of these assays are relatively low when serum samples are obtained from patients within 3 weeks after onset of erythema migrans and are tested by either the ifa method or elisa. ...	1988	3056197
mammalian and avian reservoirs for borrelia burgdorferi.		1988	3056198
synovial fluid eosinophilia in lyme disease.	we describe three 14-year-old boys who developed synovial fluid eosinophilia associated with lyme disease. one patient, with arthritis that began in 1975, had the first documented case of lyme disease in new jersey. lyme disease should be considered when eosinophilia is noted on analysis of synovial fluid from patients with undiagnosed arthritis.	1988	3056421
clinical and neuroimmunological findings in chronic borrelia burgdorferi radiculomyelitis (lyme disease).		1988	3058745
laboratory aspects of lyme borreliosis.	lyme borreliosis (lyme disease), a common tick-borne disorder of people and domestic animals in north america and europe, is caused by the spirochete borrelia burgdorferi. following the discovery and initial propagation of this agent in 1981 came revelations that other tick-associated infectious disorders are but different forms of lyme borreliosis. a challenge for the clinician and microbiology laboratory is confirmation that a skin rash, a chronic meningitis, an episode of myocarditis, or an a ...	1988	3069200
[intermittent fever attacks. lyme disease without erythema chronicum migrans].		1988	3069790
[multiple neurologic manifestations of borrelia burgdorferi infection].	the neurological spectrum of borrelia burgdorferi infections is still enlarging. we review epidemiological, pathological and serological data of lyme disease. the course of the disease is divided in three stages: stage 1 during the first month is characterised by erythema chronicum migrans and associated manifestations; stage 2 includes not only the classical european meningoradiculitis but also less specific neurological symptoms: isolated lymphocytic meningitis with an acute or even relapsing ...	1988	3070690
[a new type of spirochete infection: lyme disease].		1988	3071626
[cutaneous b cell lymphoma in chronic borrelia burgdorferi infection. report of 2 cases and a review of the literature].	low-grade malignant b-cell lymphomas of the skin can be distinguished from lymphadenosis benigna cutis (bäfverstedt) by immunohistological methods developed in the last few years. its coexistence with borrelia burgdorferi infection can be shown by clinical and serological findings. in the chronic stage of this infection, lymphocytic cell infiltrations consistent with histological and immunohistological findings of malignant b-cell lymphoma can be found. predominantly at the extremities, multiple ...	1988	3072322
[identification of borrelia isolated in the ussr from ixodes persulcatus schulze ticks].	the data on the identification of 7 spirochetal isolates from ixodes persulcatus ticks collected in leningrad province and the khabarovsk territory are presented. these isolates, studied with the use of monoclonal antibodies, have been shown to belong to borrelia burgdorferi.	1988	3072807
[vasculitic neuropathy in the garin-bujadoux-bannwarth syndrome. a contribution to the understanding of the pathology and pathogenesis of the neurological complications in lyme borreliosis].	clinical examinations and nerve biopsies were performed on four patients with meningoradiculoneuritis and positive serology for borrelia (garin-bujadoux-bannwarth syndrome). three patients had a painful multiplex mononeuropathy, while one presented with a picture resembling a guillain-barré syndrome. nerve biopsy in two patients revealed marked perivasculitis, in part with thrombosis of the epineural vasa nervorum. in the other two patients there were small pericapillary infiltrates in the endon ...	1988	3338392
measurement of antibodies to the borrelia burgdorferi flagellum improves serodiagnosis in lyme disease.	the isolation of borrelia burgdorferi flagella and an enzyme-linked immunosorbent assay (elisa) for detection of immunoglobulin g (igg) and igm to the b. burgdorferi flagellum are described. the diagnostic performance of the flagellum elisa for serodiagnosis of lyme disease was compared with the performance of a traditional whole cell b. burgdorferi sonic extract elisa. we examined sera and cerebrospinal fluid (csf) from 56 patients with lymphocytic meningoradiculitis (bannwarth's syndrome), the ...	1988	3343329
[prevalence of lyme borreliosis in a swiss population at risk].	the epidemiology of "lyme borreliosis" in europe and the significance of positive antibody titers against borrelia burgdorferi is not well known. since "orienteering", a competitive cross country sport with a map and a compass, usually in forests, elevates the risk of being bitten by ticks and infected by b. burgdorferi, nearly 1000 orienteerers were included in a prospective study. - in this population the prevalence of positive igg-antibodies (immunofluorescence technique) was almost 20% and o ...	1988	3344410
acrodermatitis chronica atrophicans.	two cases of acrodermatitis chronica atrophicans associated with borrelia burgdorferi infection are reported; to our knowledge these are the first cases reported in children.	1988	3348655
enzyme-linked immunosorbent assays for the detection of class-specific immunoglobulins to borrelia burgdorferi.	enzyme-linked immunosorbent assays were developed to detect immunoglobulin m (igm) and immunoglobulin g (igg) antibodies to borrelia burgdorferi, the etiologic agent of lyme disease. of the 135 blood samples obtained during 1985-1986 from persons in connecticut with erythema migrans or other clinical manifestations of this spirochetosis, 106 (79%) contained igm antibody. in separate tests for igg antibody, 106 (83%) of 128 specimens were considered positive. to assess the specificity of these as ...	1988	3354546
prevalence of ixodes dammini near the homes of lyme disease patients in westchester county, new york.	cases of lyme disease that occurred in westchester county, an affluent suburb north of new york city, in 1983 were investigated in 1983 and 1984 to determine the presence of ixodes dammini (acari: ixodidae) in the vicinity of the patients' homes. small mammal trapping, drag cloth, and carbon dioxide-baited tick traps were used to sample ticks. in all but one of 11 cases investigated, i. dammini was found on or near well-maintained lawns in the immediate vicinity of the residences. a mark-release ...	1988	3354547
plasmid analysis of borrelia burgdorferi, the lyme disease agent.	a simple procedure for extraction of plasmid-enriched dna from borreliae was used in a plasmid analysis of 13 strains of the lyme disease agent, borrelia burgdorferi. the extracted dna was subjected to low-percentage agarose gel electrophoresis and examined either directly by ethidium bromide staining or after hybridization of the plasmids in situ with a dna probe for the gene encoding the major outer membrane protein ospa. each isolate had four to seven discernible plasmids of various sizes. on ...	1988	3356787
fatal adult respiratory distress syndrome in a patient with lyme disease.	a dry cough, fever, generalized maculopapular rash, and myositis developed in a 67-year-old woman; she also had markedly abnormal liver function test results. serologic tests proved that she had an infection of recent onset with borrelia burgdorferi, the agent that causes lyme disease. during a two-month course of illness, her condition remained refractory to treatment with antibiotics, salicylates, and steroids. ultimately, fatal adult respiratory distress syndrome developed; this was believed ...	1988	3357244
hepatitis due to recurrent lyme disease.		1988	3358572
[schoenlein-henoch purpura in borrelia burgdorferi infection].	in a 24-year-old patient suffering from recurrent purpura schoenlein-henoch, there were found positive lyme-spirochete ift. due to the motion of titres in immune fluorescence examinations the purpura seems to be likely one form of a late manifestation in borrelia infection.	1988	3360463
[infiltrating lymphadenosis benigna cutis as borreliosis of the skin].	forms of lymphadenosis benigna cutis (lbc) which run an unusual course may present considerable problems and are sometimes difficult to distinguish from malignant lymphomas of the skin on the basis of the clinical and histological picture. the case of a female patient is reported, who presented with plaque-like infiltrative lesions on both lower arms. the lesions were interpreted as being malignant lymphomas of the skin. after a progressive course of 6 years' duration, the diagnosis of an unusua ...	1988	3360600
immunoblot analysis of immunoglobulin g response to the lyme disease agent (borrelia burgdorferi) in experimentally and naturally exposed dogs.	immunoblots were used to study the immunoglobulin g response to borrelia burgdorferi in experimentally and naturally exposed dogs. adsorption studies confirmed that the antibodies were specific for b. burgdorferi. experimentally exposed dogs were asymptomatic. naturally exposed dogs included both asymptomatic animals and animals showing signs compatible with lyme disease. naturally exposed dogs were from four geographic regions of the country. no differences were detected between immunoblot patt ...	1988	3366860
chronic central nervous system involvement in lyme borreliosis.	we describe four patients with marked chronic meningoencephalomyelitis caused by tick-transmitted borrelia burgdorferi infection. imaging techniques showed either ms-like lesions or evidence of vascular involvement, as in other spirochetal infections, especially in meningovascular syphilis.	1988	3368066
persistent intrathecal secretion of oligoclonal, borrelia burgdorferi-specific igg in chronic meningoradiculomyelitis.	in the cerebrospinal fluid igg of five patients with lymphomeningoradiculitis (bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. most of these oligoclonal bands were specific for borrelia burgdorferi. in patients suffering from chronic meningoradiculomyelitis, repeated csf examination by this technique showed persistent secretion of identical igg bands. thus, the specific humoral immune response and the disease activity could be document ...	1988	3373242