Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| serologic evidence of puumala virus infection in wild moose in northern sweden. | puumala (puu) virus is the causative agent of nephropathia epidemica, the scandinavian form of hemorrhagic fever with renal syndrome. the infection is acquired by airborne transmission of puu virus from its rodent reservoir, the bank vole. besides serologic data indicating that the virus may spread also to heterologous rodents, there is little information on the susceptibility of wild living animals to puu virus. we studied the occurrence of antibodies to puu virus in serum samples from 427 wild ... | 2000 | 10761733 |
| [clinical case of the month. a new case of nephropathia epidemica due to puumala virus]. | nephropathia epidemica due to puumala virus has already been described in belgium. its evolution is usually favourable. the main symptoms are fever, a decrease platelet count, proteinuria and acute renal insufficiency, which, in an epidemiological context, quickly point the correct diagnosis. acute and transitory myopia is typical. nevertheless, the clinical presentation, including multisystemic symptoms may lead to the false diagnosis of an acute bacterial or immune disease. | 2000 | 10769579 |
| of mice, men, and microbes-hantavirus | 2000 | 10613808 | |
| seroepidemiology of hantavirus in the philippines. | this study was undertaken to determine the seroepidemiology of hantavirus infection in the philippines. | 2000 | 10737848 |
| hantavirus pulmonary syndrome--panama, 1999-2000. | hantavirus pulmonary syndrome (hps) is an acute viral rodentborne zoonosis characterized by severe cardiopulmonary illness with a 40%-60% case-fatality rate. since its identification in the united states in 1993, the recognized clinical spectrum of illnesses associated with human hantavirus infection has expanded to include mild illness, and case-patients have been identified in canada and south america. this report describes the first confirmed hps cases from central america and summarizes prel ... | 2000 | 10738839 |
| spatial and temporal dynamics of puumala hantavirus infection in red bank vole (clethrionomys glareolus) populations in belgium. | dynamics of hantavirus infection and population densities in rodents were investigated from 1996 to 1999 in southern belgium. evidence of puumala infection was restricted to clethrionomys glareolus. although the serotype was not determined, antibodies against hantavirus were also found in eight apodemus sylvaticus. in fall 1996, the seroprevalence in c. glareolus was high (20.1%, 37 of 184) and the infection was widely distributed in the area studied whereas a focal occurrence of positive rodent ... | 2000 | 10773322 |
| epidemiology of community-acquired pneumonia in adults: a population-based study. | in this prospective study, the authors assessed the incidence, aetiology, and outcome of patients with community-acquired pneumonia in the general population. from december 1993 to november 1995, a study was performed in a mixed residential-industrial urban population of the "maresme" region in barcelona, spain. all subjects > or =14 yrs of age (annual average population size 74,368 inhabitants) with clinically suspected community-acquired pneumonia were registered. all cases were re-evaluated b ... | 2000 | 10780770 |
| genetic analysis of sin nombre hantavirus in iowa. | 2000 | 10783030 | |
| antigenic properties and diagnostic potential of recombinant dobrava virus nucleocapsid protein. | dobrava hantavirus (dobv) causes severe hemorrhagic fever with renal syndrome in the balkan region and has been detected recently also in russia, estonia, and germany. dobv nucleocapsid protein (n) was produced in insect cells, using the baculovirus expression system (bac-dobv-n), and in e. coli as a truncated (aa 1-165) glutathione-s transferase fusion protein (dobv-dn-gst). the antigenic properties of bac-dobv-n were found identical to native dobv-n when examined by a panel of hantavirus-speci ... | 2000 | 10797384 |
| [epidemiologic problems in hantavirus infections]. | the objective of the submitted paper was to present some information pertaining to epidemiological problems of hantavirus infection. in the czech republic the prevalence of these infections is not alarming but in the world cases of haemorrhagic fever with renal syndrome (hfrs) as well as hantavirus pulmonary syndrome (hps) are reported. on the territory of the czech republic there are foci of hantaviruses and in conjunction with summer tourism or working activities abroad the import of this infe ... | 2000 | 10802945 |
| from the centers for disease control and prevention. hantavirus pulmonary syndrome--panama, 1999-2000. | 2000 | 10807372 | |
| [acute renal failure in hantavirus infections]. | background: the acute renal failure remains a diagnostic challenge for the clinician. case reports: between 1991 and 1996, acute renal failure caused by hantavirus infection was diagnosed in 4 previously healthy male patients. main symptoms consisted of fever, headache, arthralgia, lumbar and abdominal pain as well as a decline in diuresis. the ultrasonography showed a slight splenomegaly in 2 patients. the clinical chemistry showed elevated serum creatinine from 2.2 mg/dl to 6.7 mg/dl and throm ... | 2000 | 10808304 |
| immunoglobulin a responses to puumala hantavirus. | puumala hantavirus (puuv) causes nephropathia epidemica (ne), a form of haemorrhagic fever with renal syndrome that occurs in northern and central europe. the immunoglobulin a (iga) response in ne patients was studied. the levels of total serum iga in acute-phase samples from ne patients were found to be significantly elevated when compared with the levels in healthy controls. elisas for detection of the iga1 and iga2 responses against each puuv structural protein (n, g1 and g2) were developed a ... | 2000 | 10811929 |
| outbreak of hantavirus infection in the four corners region of the united states in the wake of the 1997-1998 el nino-southern oscillation. | hantavirus cardiopulmonary syndrome (hcps), a rodent-borne zoonosis, has been endemic in the americas for at least several decades. it is hypothesized that the 1991-1992 el niño-southern oscillation (enso) caused increased precipitation that allowed an increase in rodent population densities, thereby increasing the possibility of transmission to humans. the result was a 1993-1994 outbreak of the disease in the four corners states of the southwestern united states. a second strong enso occurred i ... | 2000 | 10823755 |
| clinical aspects of nephropathia epidemica (puumala virus infection) in europe: a review. | nephropathia epidemica (ne) is a prevalent zoonosis throughout europe and is caused by the puumala type of hantavirus. the incidence of ne varies in a cyclic fashion, with peaks occurring every 3rd to 4th year, coinciding with peaks in vole populations. the clinical course of ne is generally milder than haemorrhagic fever with renal syndrome caused by hantaviruses in other parts of the world. typically, ne has a sudden onset with fever, headache, backpain and gastrointestinal symptoms. however, ... | 2000 | 10826895 |
| using remotely sensed data to identify areas at risk for hantavirus pulmonary syndrome. | the 1993 u.s. hantavirus pulmonary syndrome (hps) outbreak was attributed to environmental conditions and increased rodent populations caused by unusual weather in 1991- 92. in a case-control study to test this hypothesis, we estimated precipitation at 28 hps and 170 control sites during the springs of 1992 and 1993 and compared it with precipitation during the previous 6 years by using rainfall patterns at 196 weather stations. we also used elevation data and landsat thematic mapper satellite i ... | 2000 | 10827113 |
| remote sensing and geographic information systems: charting sin nombre virus infections in deer mice. | we tested environmental data from remote sensing and geographic information system maps as indicators of sin nombre virus (snv) infections in deer mouse (peromyscus maniculatus) populations in the walker river basin, nevada and california. we determined by serologic testing the presence of snv infections in deer mice from 144 field sites. we used remote sensing and geographic information systems data to characterize the vegetation type and density, elevation, slope, and hydrologic features of ea ... | 2000 | 10827114 |
| renal failure and hantavirus infection in europe. | 2000 | 10831620 | |
| diagnostic potential of puumala virus nucleocapsid protein expressed in drosophila melanogaster cells. | puumala virus (puu) nucleocapsid protein (n) was expressed in insect cells by using the drosophila expression system (des; invitrogen bv, groningen, the netherlands). stable transfectants were established by hygromycin b selection and showed continuous expression of the recombinant protein (des-puu-n) for at least 5 months. the antigenic property of des-puu-n was shown to be identical to that of native puu n when examined with a panel of hantavirus-specific monoclonal antibodies. enzyme-linked i ... | 2000 | 10834996 |
| hantavirus pulmonary syndrome in canada, 1989-1999. | 2000 | 10851764 | |
| [detection for anti-hantavirus igm in patient serum with silver enhanced dot immunogold filtration assay]. | to establish a more rapid and simple method for detecting anti-hantavirus igm in patient' s serum. | 2000 | 11498694 |
| the public health laboratory service (phls) and its role in the control of zoonotic disease. | the aetiology of zoonotic infections embraces organisms from every branch of the microbial world. in addition, zoonoses must be considered as a truly global problem, both in terms of their distribution and the measures required for their control. within the uk, zoonotic disease is considered to be less frequent than in some less developed parts of the world. however, its contribution to overall morbidity and mortality within the uk population is not well established. in an attempt to define the ... | 2000 | 10913770 |
| genetic diversity, distribution, and serological features of hantavirus infection in five countries in south america. | since 1995 when the first case of hantavirus pulmonary syndrome (hps) was reported in patagonia, there have been more than 400 cases of hps reported in five countries in south america. the first case of hps was associated with andes (and) virus. in this study, we report on the genetic diversity, geographical distribution, and serological features of hantavirus infection in six countries in south america based on 87 hps cases from argentina, bolivia, chile, paraguay, and uruguay. an early immunog ... | 2000 | 10921972 |
| genetic analysis of wild-type dobrava hantavirus in slovenia: co-existence of two distinct genetic lineages within the same natural focus. | genetic analysis was performed of wild-type (wt) dobrava hantavirus (dob) strains from slovenia, the country where the virus was first discovered and where it was found to cause haemorrhagic fever with renal syndrome (hfrs), with a fatality rate of 12%. two hundred and sixty mice of the genus apodemus:, trapped in five natural foci of dob-associated hfrs during 1990-1996, were screened for the presence of anti-hantavirus antibodies and 49 apodemus: flavicollis and four apodemus: agrarius were fo ... | 2000 | 10859380 |
| annual update of systemic disease--1999: emerging and re-emerging infections (part ii). | 2000 | 10770510 | |
| emerging infectious diseases: a cause for concern. | as the twenty-first century begins it becomes increasingly apparent that the twentieth century, which opened with the promise of the eradication of most infectious diseases, closed with the specter of the reemergence of many deadly infectious diseases that have a rapidly increasing incidence and geographic range. equally if not more alarming is the appearance of new infectious diseases that have become major sources of morbidity and mortality. among recent examples are hiv/aids, hantavirus pulmo ... | 2000 | 11344776 |
| [serologic study of the prevalence and course of hantavirus infections in mecklenburg-vorpommern]. | 694 sera obtained from 1994 till 1998 in the general population were examined with a recombinant enzyme immunoassay for hantavirus antibodies against the serotypes hantaan and puumala. positive samples were retested for confirmation with an indirect immunofluorescence assay and a recombinant immunoblot. the observed antibody prevalence of 0.9% signities that mecklenburg-vorpommern is not an endemic area. 12 out of 196 patients with a suspected hantavirus infection were confirmed. all proved anti ... | 2000 | 10740354 |
| [the partial nucleotide sequence of l segment of hantavirus strain]. | to study the nucleotide sequence of l segment of hantavirus strain a9. | 2000 | 11503036 |
| sex differences in seoul virus infection are not related to adult sex steroid concentrations in norway rats. | field studies of hantavirus infection in rodents report that a higher percentage of infected individuals are males than females. to determine whether males were more susceptible to hantavirus infection than females, adult male and female long evans rats (rattus norvegicus) were inoculated with doses of seoul virus ranging from 10(-4) to 10(6) pfu. the 50% infective doses (id(50)) were not significantly different for male and female rats (10(0.05) and 10(0.8) pfu, respectively). to determine whet ... | 2000 | 10933735 |
| humoral immune responses in the hantavirus cardiopulmonary syndrome. | the immunologic responses that mediate viral clearance of and recovery from hantavirus cardiopulmonary syndrome (hcps) due to sin nombre (sn) virus are unknown. serial serum samples from 26 patients with acute sn virus infection were tested for igg, iga, and igm reactivity to recombinant viral nucleocapsid (n) and glycoprotein g1 antigens by a novel strip immunoblot assay. the titers of antibodies capable of neutralizing sn virus in vitro also were determined for each sample. at admission, patie ... | 2000 | 10882580 |
| [febrile cytolysis disclosing hemorrhagic fever with renal syndrome]. | we report the case of a 40-year-old-man who developed febrile cytolysis as the presenting sign of hemorragic fever with renal syndrome (hfrs). on admission, he had fever (40 degrees c) and epigastric pain. the ast level was at 2n, the alt at 3n. there was a thrombocytopenia (61 000/mm(3)) without anemia or hyperleukocytosis. three days after admission, the platelet count decreased to 40 000/mm(3), serum urea and creatinine increased from normal rate to 10.8mmol/l, 204.0 micromol/l, respectively. ... | 2000 | 11173712 |
| [microbiological surveillance: viral hemorrhagic fever in central african republic: current serological data in man]. | an investigation was conducted between 1994 and 1997 in forested areas of the central african republic (car) to determine the seroprevalence of igg antibodies against several haemorrhagic fever viruses present in the region. sera were obtained from 1762 individuals in two groups (pygmy and bantu locuted populations) living in 4 forested areas in the south of the country. sera were tested for igg antibodies against ebola, marburg, rift valley fever (rvf), yellow fever (yf) and hantaviruses by enz ... | 2000 | 11775321 |
| [nephropathia epidemica and other hanta virus infections: how rodents' viruses cause disease in human?]. | 2000 | 11764460 | |
| [study on the genetic difference of seo type hantaviruses]. | to understand the genetic type of hantaviruses and the difference between them caused by rodents in beijing and to furhter explore the source of the infectious factors. | 2000 | 11860814 |
| [safety and immunogenicity of inactivated bivalent ehf vaccine in humans]. | safety and immunogenicity of inactivated bivalent ehf vaccine in humans were evaluated in the epidemic area of zhejiang province, china. | 2000 | 11860832 |
| [discovery of a new subtype of seo virus]. | the m and s segments of cou3, a hantavirus strain isolated from rattus norvegieus were partially reverse transcripted, pcr amplified and sequenced with abi 373 dna sequencer to observe the differences from other seo type viruses. | 2000 | 11471015 |
| hantavirus update on an emerging--and lethal--infectious disease. | 2000 | 11503410 | |
| hantavirus pulmonary syndrome in the americas: the early years. | the initial recognition of hantavirus pulmonary syndrome (hps) as a new disease associated with a cluster of acute respiratory deaths among american indians in the southwestern united states in 1993 bears little resemblance to the current understanding of this syndrome. hps is now recognized as a zoonotic disease that has been endemic throughout the americas for at least 40 years and that is closely linked to population densities and virus dynamics among a specific subfamily of rodents. the clas ... | 2000 | 16088742 |
| hantavirus pulmonary syndrome: an alert to latin american countries. | approximately 400 cases of hantavirus pulmonary syndrome (hps) have been reported on the north american continent since the first epidemic in 1993, in new mexico, usa. in brazil, 12 cases were confirmed before 1998. infection results from inhalation of rodent blood, saliva or waste. clinical findings of the disease are characterized by a nonspecific febrile illness, followed by rapid progression to pulmonary edema which may lead to a shock-like state or renal failure. mortality is high and emerg ... | 1999 | 11084670 |
| epidemiological progresses of hemorrhagic fever with renal syndrome in china. | to summarize the major achievements of chinese work on the epidemiology and prevention of hemorrhagic fever with renal syndrome (hfrs) in recent years, and to give a general review on the present situation of hfrs in china. | 1999 | 11593522 |
| superovulation in vesper mice, calomys laucha--an important biomedical model for hantavirus and arenavirus (rodentia-sigmodontinae). | sigmodontine rodents are poorly studied and have not received much attention as a reproductive model. renewed interest in the south american rodents has been stimulated by their link to endemic diseases that are transmitted to man. calomys laucha acts as a reservoir of two dangerous viruses: an arenavirus named 'junin virus', the aetiological agent of argentinian haemorrhagic fever, and the hantavirus, both of which constitute serious sanitary problems. the aim of this study was to establish sui ... | 1999 | 10778786 |
| cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. | hantaviruses replicate primarily in the vascular endothelium and cause two human diseases, hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). in this report, we demonstrate that the cellular entry of hfrs-associated hantaviruses is facilitated by specific integrins expressed on platelets, endothelial cells, and macrophages. infection of human umbilical vein endothelial cells and vero e6 cells by the hfrs-causing hantaviruses hantaan (htn), seoul (seo), and puum ... | 1999 | 10196290 |
| [topics of emerging, re-emerging infectious diseases]. | 1999 | 10866500 | |
| [an epidemiological analysis of hemorrhagic fever with renal syndrome morbidity in the republic of bashkortostan in 1997]. | the outbreak of hemorrhagic fever with renal syndrome (hfrs) in the republic of bashkortostan, resulting in 10,057 registered cases of the disease (287 cases per 100,000 of the population), was analyzed. hfrs cases among the population were registered in 52 out of 54 regions of bashkortostan. 31% of the total number of patients were the inhabitants of rural regions (170 cases per 100,000) and 69% were urban dwellers (295 cases per 100,000), mainly in ufa (512 cases per 100,000). hfrs morbidity a ... | 1999 | 10876849 |
| [hantavirus in chile: review and cases analysis since 1975]. | since the identification of the first case of hantavirus infection in chile in 1995, a great advance in the knowledge of the disease natural history has occurred. there is evidence to suppose that the infection by andes virus in suburban areas of argentina and chile, whose natural reservoir is oligoryzomys longicaudatus, has been present but unidentified for a long time. we describe a serologically proven case occurred in 1975. the clinical presentation of the disease slightly differs from that ... | 1999 | 10835761 |
| a case-control study after a hantavirus infection outbreak in the south of belgium: who is at risk? | puumala is the most common hantavirus serotype in europe and is spread mainly by the red bank vole. between 1 july 1992 and 31 january 1994, an outbreak of puumala virus-induced nephropathia epidemica (ne) occurred in the belgian ardennes. serologically confirmed cases (n = 41) were compared with two groups of asymptomatic seronegative controls. risks identified included sighting of living rodents, exposure to rodent droppings, and trapping rodents during the 4 weeks preceding onset of symptoms. ... | 1999 | 10825047 |
| hemorrhagic fever with renal syndrome in the dolenjska region of slovenia--a 10-year survey. | this report describes the first investigation of clinical findings for a larger series of patients with hemorrhagic fever with renal syndrome (hfrs) who were infected with dobrava virus. from 1985 to 1995, 38 patients with serologically confirmed hfrs were hospitalized at the regional hospital in novo mesto in the dolenjska region of slovenia. on the basis of results of serological examination, 24 patients had dobrava virus infection, and 14 patients had puumala virus infection. complete clinica ... | 1999 | 10825051 |
| hantavirus-specific igg, igm, and iga in acute and chronic renal disease versus congenital renal disease in the united states. | in a blinded fashion, 165 serum samples from patients with biopsy-characterized acute and chronic renal diseases (acrds), 34 serum samples from patients with congenital renal diseases (crds), and 100 serum samples from healthy adults were assayed for immunoglobulin g (igg), igm, and iga antibodies to hantaan and puumala viruses by enzyme immunoassay (eia). twenty-six percent (44 of 165) of acrds, 3% (1 of 34) of crds, and none (0 of 100) of the healthy serum samples were positive for hantavirus- ... | 1999 | 10196017 |
| urban leptospirosis versus urban hantavirus infection in brazil. | 1999 | 10622333 | |
| dobrava hantavirus in russia. | 1999 | 9923881 | |
| spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. | hantaviruses chronically infect rodents without apparent disease, but when they are spread by aerosolized excreta to humans, two major clinical syndromes result: hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). both diseases appear to be immunopathologic, and inflammatory mediators are important in causing the clinical manifestations. in hps, t cells act on heavily infected pulmonary endothelium, and it is suspected that gamma interferon and tumor necrosis fa ... | 1999 | 10073292 |
| isolation and characterization of dobrava hantavirus carried by the striped field mouse (apodemus agrarius) in estonia. | dobrava hantavirus (dob) was isolated from the striped field mouse (apodemus agrarius) trapped on saaremaa island, estonia, and its genetic and antigenic characteristics were subsequently analysed. phylogenetic analysis showed that the estonian dob strain, together with several wild strains carried by apodemus agrarius, forms a well-supported lineage within the dob clade. the topography of the trees calculated for the s, m and l nucleotide sequences of the estonian dob suggests a similar evoluti ... | 1999 | 10073697 |
| intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. ribavirin study group. | intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (hps) in the united states between 4 june 1993 and 1 september 1994. therapy was initiated prior to laboratory confirmation of hantavirus infection because most deaths from hps occur within 48 h of hospitalization. thirty patients with confirmed hps, 105 patients without hps and 5 patients without adequate diagnostic testing for hps were enrolled. this ... | 1999 | 10723500 |
| hantavirus (bunyaviridae) infections in rodents from orange and san diego counties, california. | 1999 | 10674658 | |
| hantavirus infections in rodents | 1999 | 10674659 | |
| seroprevalence study of hantavirus infection in the community based population. | the genus hantavirus, family bunyaviridae, comprise at least 20 distinct viruses. ten of these have been linked to specific human diseases. hemorrhagic fever with renal syndrome has been recognized since the 1950s. hantavirus pulmonary syndrome was recognized in the united states in 1993. epizootiologic studies of norway rats in the baltimore area have shown that rodent infections with hantaviruses are common and geographically widespread with prevalence reaching 44% in tested rat populations. t ... | 1999 | 10628132 |
| rapidly evolving adult respiratory distress syndrome with eosinophilia of unknown cause in previously healthy active duty soldiers at an army training center: report of two cases. | two previously healthy soldiers presented with rapidly evolving adult respiratory distress syndrome (ards) within days of their return from the national training center at fort irwin, california. there have been six similar cases reported in the national training center area, five with fatal outcomes. | 1999 | 10628168 |
| newer pediatric pathogens. | newer laboratory techniques have allowed the detection of previously unrecognized microbial agents that are now pathogenic in children, as well as newly recognized manifestations of previously known pathogens. clinical reports of these newer agents or manifestations are reviewed so that pediatricians can become familiar with these emerging infectious diseases. physicians need to consider these organisms in the differential diagnosis in appropriate clinical illnesses. | 1999 | 10645465 |
| high levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. | hantavirus pulmonary syndrome (hps) is characterized by the rapid onset of pulmonary edema and a high case-fatality rate. hantavirus antigens have been demonstrated in pulmonary capillary endothelial cells, but the mechanisms causing capillary leakage remain unclear. immunohistochemical staining was used to enumerate cytokine-producing cells (monokines: interleukin [il]-1alpha, il-1beta, il-6, and tumor necrosis factor [tnf]-alpha; lymphokines: interferon-gamma, il-2, il-4, and tnf-beta) in tiss ... | 1999 | 9878011 |
| dynamics of puumala hantavirus infection in naturally infected bank voles (clethrinomys glareolus). | specific features of hantavirus infection in bank vole (clethrionomys glareolus) were studied in the endemic area of hemorrhagic fever with renal syndrome (hfrs) in the foothills of the ural mountains, using long-term observations on living animals by the capture-mark-recapture (cmr) method. the results demonstrated that the infection naturally circulating in the voles is chronic (lasting for up to 15 months) and asymptomatic, with a peak of puumala virus accumulation and release from the organi ... | 1999 | 10664394 |
| update on emerging infections from the centers for disease control and prevention. hantavirus pulmonary syndrome--colorado and new mexico, 1998. | 1999 | 9867901 | |
| chronic renal failure after puumala virus infection. | chronic renal failure has never been described after puumala hantavirus infection, which usually causes acute renal failure with spontaneous full recovery. we report a 15-year-old boy who presented with puumala hantavirus infection and initial severe acute renal failure. his renal function gradually improved, but more than 2 years after the acute episode it was still moderately impaired, with a creatinine clearance of about 60 ml/min per 1.73 m(2) | 1999 | 10603154 |
| hantavirus reservoir hosts associated with peridomestic habitats in argentina. | five species of sigmodontine rodents have been identified in argentina as the putative reservoirs of six circulating hantavirus genotypes. two species of oligoryzomys are associated with the genotypes causing hantavirus pulmonary syndrome, oligoryzomys flavescens for lechiguanas and o. longicaudatus for andes and oran genotypes. reports of human cases of hantavirus pulmonary syndrome prompted rodent trapping (2,299 rodents of 32 species during 27,780 trap nights) at potential exposure sites in t ... | 1999 | 10603213 |
| epidemiological study of nephropathia epidemica in finland 1989-96. | this study presents data on 33,000 serum samples studied from july 1989 to june 1996 in finland, with 6,701 serologically confirmed puumala virus (puu) infections. in addition, a puu serosurvey of 8,000 sera from finland is presented. on average, 957 puu infections were detected annually, resulting in an incidence of 19/100,000; mortality was less than 0.1%. the infection was most common in the district of ita-savo with an incidence of 90/100,000. the seasonal peak was in november-december; howe ... | 1999 | 10576121 |
| n-acetylgalactosamine (galnac)-specific lectins mediate enhancement of hantaan virus infection. | summary. n-acetylgalactosamine (galnac)-specific lectins, dolichos biflorus agglutinin (dba), and soybean agglutinin (sba), enhanced hantaan (htn) virus infections in vero e6 and p388d1 cells. treatment of vero e6 cells with the lectins either before or during, but not after, virus inoculation resulted in lectin-mediated enhancement of infection (lme), indicating that galnac-specific lectin affects an early stage of the infection. lectin blot and facs analysis showed that the ability of htn viru ... | 1999 | 10542025 |
| hantavirus pulmonary syndrome in pregnancy. | this comprehensive case review of hantavirus pulmonary syndrome (hps) during pregnancy in 5 women characterizes the effect of sin nombre virus infection on maternal and fetal outcomes. histopathologic, serological, and clinical information were evaluated for evidence of vertical transmission. maternal ages ranged from 20 to 34 years and gestational ages from 13 to 29 weeks. symptoms, physical findings, and laboratory values other than those related to pregnancy were not noticeably different from ... | 1999 | 10585809 |
| absence of infection in a neonate after possible exposure to sin nombre hantavirus in breast milk. | 1999 | 10585821 | |
| absence of interhuman transmission of hantavirus pulmonary syndrome in minas gerais, brazil: evidence from a serological survey. | 1999 | 10585829 | |
| acute sin nombre hantavirus infection without pulmonary syndrome, united states. | hantavirus pulmonary syndrome (hps) occurs in most infections with sin nombre virus and other north american hantaviruses. we report five cases of acute hantavirus infection that did not fit the hps case definition. the patients had characteristic prodromal symptoms without severe pulmonary involvement. these cases suggest that surveillance for hps may need to be expanded. | 1999 | 10511527 |
| temporal and spatial analysis of sin nombre virus quasispecies in naturally infected rodents. | sin nombre virus (snv) is thought to establish a persistent infection in its natural reservoir, the deer mouse (peromyscus maniculatus), despite a strong host immune response. snv-specific neutralizing antibodies were routinely detected in deer mice which maintained virus rna in the blood and lungs. to determine whether viral diversity played a role in snv persistence and immune escape in deer mice, we measured the prevalence of virus quasispecies in infected rodents over time in a natural setti ... | 1999 | 10516063 |
| acute infection with sin nombre hantavirus without pulmonary edema. | acute infection with sin nombre virus has been associated with development of hantavirus cardiopulmonary syndrome (hcps), a severe cardiopulmonary illness with respiratory failure and shock. we present two cases of sin nombre hantavirus infections that did not lead to marked pulmonary complications in two otherwise healthy young adults from utah and california. sin nombre virus causes a wider spectrum of disease severity than has been previously reported. | 1999 | 10530462 |
| apoptosis is induced by hantaviruses in cultured cells. | hantaviruses replicate in primary and cultured animal cells with little or no cytopathic effect. we report here that the cultured vero e6 cells infected by the hantaan or by the prospect hill viruses exhibited characteristic features of apoptosis, including condensation and segmentation of nuclei and internucleosomal cleavage of nuclear dna. apoptosis was not seen in the cells adsorbed by uv-inactivated virus, indicating that the viral replication is required for the induction of apoptosis. furt ... | 1999 | 10544134 |
| [circulation of seoul hantavirus in populations of synanthropic rodents and its significance in the incidence of hemorrhagic fever with renal syndrome in the primorye territory]. | the prevalence of seoul virus in the primorie territory is presented and its significance in the morbidity structure with regard to hemorrhagic fever with the renal syndrome (hlps) is discussed. epidemiological and clinical manifestations of hlps caused by seoul virus are described. the authors conclude that in the urban foci of hlps it is associated mainly with seoul virus, while in the rural foci, with hantaan virus. | 1999 | 10544448 |
| high levels of viremia in patients with the hantavirus pulmonary syndrome. | hantavirus pulmonary syndrome (hps) is a rare but acute fulminant disease caused by sin nombre virus (snv). to understand the role of the viral load in the pathogenesis of hps, the load of virus in the blood of patients with hps was measured. a quantitative reverse transcription-polymerase chain reaction assay was developed for snv, because snv is difficult to grow in cell culture. thirty-eight samples from 26 patients with hps were analyzed. twenty of the 26 initial samples were positive for vi ... | 1999 | 10558964 |
| characterization of the hantaan nucleocapsid protein-ribonucleic acid interaction. | the nucleocapsid (n) protein functions in hantavirus replication through its interactions with the viral genomic and antigenomic rnas. to address the biological functions of the n protein, it was critical to first define this binding interaction. the dissociation constant, k(d), for the interaction of the hantaan virus (htnv) n protein and its genomic s segment (vrna) was measured under several solution conditions. overall, increasing the nacl and mg(2+) in these binding reactions had little imp ... | 1999 | 10559265 |
| chronic renal dysfunction after hantavirus infection. | 1999 | 10328510 | |
| [baculovirus: an example of an insect virus of use to humans]. | baculovirus is a viral pathogen of insects in general and lepidoptera in particular. the genome of this large virus consists of a circular, infectious bicatenary dna molecule. at the end of its replication cycle in insects, baculovirus produces a large quantity of at least two proteins, i.e., polyedrine and polypeptide p10. these proteins are essential for transmission of the virus in nature, but are not necessary in cell cultures. using molecular recombinant techniques, one or both of the genes ... | 1999 | 10901857 |
| hantavirus nephropathy in a child. | 1999 | 10328509 | |
| risk factors for human hantavirus infection: franco-belgian collaborative case-control study during 1995-6 epidemic. | 1999 | 10381709 | |
| [new aspects of the pathogenesis of hantavirus infections. a systemic disease with general vascular changes]. | 1999 | 10354671 | |
| isolation and characterization of a hantavirus from lemmus sibiricus: evidence for host switch during hantavirus evolution. | a novel hantavirus, first detected in siberian lemmings (lemmus sibiricus) collected near the topografov river in the taymyr peninsula, siberia (a. plyusnin et al., lancet 347:1835-1836, 1996), was isolated in vero e6 cells and in laboratory-bred norwegian lemmings (lemmus lemmus). the virus, named topografov virus (top), was most closely related to khabarovsk virus (kbr) and puumala viruses (puu). in a cross focus reduction neutralization test, anti-top lemmus antisera showed titers at least fo ... | 1999 | 10364307 |
| rodent control may help prevent human hantavirus infection | 1999 | 10381750 | |
| hantavirus in the americas. | 1999 | 10382376 | |
| [increased travelling--increased risk of imported viruses. a review of the diagnostic capacity of the swedish institute for infectious disease control]. | the increase in global travel, especially by air, has facilitated the spread of infectious agents from one part of the world to another. returning travellers are often vectors for viral disease import to sweden. while dengue fever has been quite frequently diagnosed during the past five years, especially in travellers returning from thailand, only isolated cases of sandfly fever, japanese encephalitis and ross river fever have been seen. dobrava virus was recently shown to have caused a severe f ... | 1999 | 10405531 |
| [hantavirus infections in belgium]. | hantavirus disease is a recently recognised zoonosis. the main vectors are infected but healthy wild rodents or laboratory rats. transmission to man occurs via contact with, or inhalation of aerosolised excretions. the target organs in man are the kidney (old world) or the lung (new world), probably via a local hyperproduction of pro-inflammatory cytokines. to date, more than 33 different hantaviruses have been characterised, at least 14 of them being of clinical importance. each serotype has it ... | 1999 | 10655777 |
| hantavirus dobrava infection with pulmonary manifestation. | dobrava virus infection was diagnosed serologically by enzyme-linked immunosorbent and immunofluorescence assays. to determine which hantavirus serotype was involved, sera were analyzed by a focus reduction neutralization test. the clinical data indicated that only pulmonary manifestation was present. our data support the presence of dobrava virus infection outside the balkan region. in conclusion, a previously healthy adult with unexplained pulmonary perfusion failure should be investigated for ... | 1999 | 10691093 |
| antibody responses in humans to an inactivated hantavirus vaccine (hantavax). | hantaviruses cause haemorrhagic fever with renal syndrome (hfrs) and result in severe human morbidity and mortality. safe and effective vaccines are needed urgently in order to reduce the incidence of human illness. hitherto studies of hantavirus vaccine efficiency have been limited to individuals at low risk of infection. in this study the immune response to an inactivated hantavirus vaccine was measured in 64 human volunteers at high risk of infection by virtue of residence and occupation. 30 ... | 1999 | 10418904 |
| a new clethrionomys-derived hantavirus from germany: evidence for distinct genetic sublineages of puumala viruses in western europe. | puumala (puu) viruses are the predominant etiologic agents of hantavirus infections in europe. the most important reservoir is the bank vole, clethrionomys glareolus (cg), belonging to the subfamily arvicolinae of the muridae family. here we report on the molecular characterization of the first rodent-derived sequence (puu/cg-erft) from germany. comparison of the s and m segment coding regions revealed 92.5 and 92.8% identity, respectively, with puu/h-9013, a human isolate from france. however, ... | 1999 | 10475080 |
| update: hantavirus pulmonary syndrome--united states, 1999. | 1999 | 10510528 | |
| genetic investigation of novel hantaviruses causing fatal hps in brazil. | although hantavirus pulmonary syndrome (hps) was discovered in north america in 1993, more recent investigations have shown that the disease is a much larger problem in south america, where a greater number of cases and hps-associated viruses have now been detected. here we describe the genetic investigation of three fatal hps cases from brazil, including a 1995 case in castelo dos sonhos (cas) in the state of mato grosso and two 1996 cases in the counties of araraquara (ara) and franca (fra), i ... | 1999 | 10534737 |
| comparison of the protective efficacy of naked dna, dna-based sindbis replicon, and packaged sindbis replicon vectors expressing hantavirus structural genes in hamsters. | seoul virus (seov) is a member of the hantavirus genus (family bunyaviridae) and an etiological agent of hemorrhagic fever with renal syndrome. the medium (m) and small (s) gene segments of seov encode the viral envelope glycoproteins and nucleocapsid protein, respectively. we compared the immunogenicity and protective efficacy of naked dna (pwrg7077), dna-based sindbis replicon (psin2.5), and packaged sindbis replicon vectors (psinrep5), containing either the m or s gene segment of seov in syri ... | 1999 | 10544095 |
| hantavirus infections: epidemiology and pathogenesis. | hantaviruses are enveloped rna viruses that persistently infect rodent hosts without ill-effect. the host persistently excretes virus in urine and saliva. man becomes infected from the rodents when one enters the ecological niche of the other. there are two major clinical presentations--haemorrhagic fever with renal syndrome, found worldwide in various forms and hantavirus pulmonary syndrome, found only in the americas. this review examines the virology, epidemiology and pathogenesis of these em ... | 1999 | 10580279 |
| [the pathogenicity of hfrs patient's soft palate mucosa to suckling mice]. | to explore the pathogenic mechanism of hemorrhagic fever with renal syndrome(hfrs). | 1999 | 12759963 |
| sin nombre virus pathogenesis in peromyscus maniculatus. | sin nombre virus (snv), a member of the hantavirus genus, causes acute viral pneumonia in humans and is thought to persistently infect mice. the deer mouse, peromyscus maniculatus, has been identified as the primary reservoir host for snv. to understand snv infection of p. maniculatus, we examined wild deer mice for localization of viral antigens and nucleic acid. morphologic examination consistently revealed septal edema within lung tissue and mononuclear cell infiltrates in portal areas of the ... | 1999 | 9847363 |
| recombination in tula hantavirus evolution: analysis of genetic lineages from slovakia. | to examine the evolution of tula hantavirus (tul), carried by the european common vole (microtus arvalis and m. rossiaemeridionalis), we have analyzed genetic variants from slovakia, the country where the virus is endemic. phylogenetic analysis (phylip) based on either partial (nucleotides [nt] 441 to 898) or complete n-protein-encoding sequences divided slovakian tul variants into two main lineages: (i) strains from eastern slovakia, which clustered with russian strains, and (ii) strains from w ... | 1999 | 9847372 |
| new york 1 and sin nombre viruses are serotypically distinct viruses associated with hantavirus pulmonary syndrome. | new york 1 virus (ny-1) and sin nombre virus (sn) are associated with hantavirus pulmonary syndrome (hps). ny-1 and sn are derived from unique mammalian hosts and geographic locations but have similar g1 and g2 surface proteins (93 and 97% identical, respectively). focus reduction neutralization assays were used to define the serotypic relationship between ny-1 and sn. sera from ny-1-positive peromyscus leucopus neutralized ny-1 and sn at titers of >/=1/3,200 and </=1/400, respectively (n = 12). ... | 1999 | 9854075 |
| emerging viral infections. | 1999 | 10079847 | |
| [acute hantavirus infection caused by a genetically newly identified viral strain. severe and complicated course of hemorrhagic fever with renal syndrome (nephropathia epidemica)]. | a 49-year-old patient, a hobby hunter, fell ill acutely with joint and limb pain, abdominal pain, nausea and subfebrile temperatures. at hospitalization, the patient was in bad general condition, showing ascites and lid edema, and acute renal failure was diagnosed. | 1999 | 10081288 |
| genetic diversity and distribution of peromyscus-borne hantaviruses in north america. | the 1993 outbreak of hantavirus pulmonary syndrome (hps) in the southwestern united states was associated with sin nombre virus, a rodent-borne hantavirus; the virus' primary reservoir is the deer mouse (peromyscus maniculatus). hantavirus-infected rodents were identified in various regions of north america. an extensive nucleotide sequence database of an 139 bp fragment amplified from virus m genomic segments was generated. phylogenetic analysis confirmed that snv-like hantaviruses are widely d ... | 1999 | 10081674 |
| climatic and environmental patterns associated with hantavirus pulmonary syndrome, four corners region, united states. | to investigate climatic, spatial, temporal, and environmental patterns associated with hantavirus pulmonary syndrome (hps) cases in the four corners region, we collected exposure site data for hps cases that occurred in 1993 to 1995. cases clustered seasonally and temporally by biome type and geographic location, and exposure sites were most often found in pinyon-juniper woodlands, grasslands, and great basin desert scrub lands, at elevations of 1,800 m to 2,500 m. environmental factors (e.g., t ... | 1999 | 10081675 |