Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| non-cell corynebacterium parvum generated by nanotechnology: a promising immunomodulator with less side effects. | corynebacterium parvum (cp), a kind of immunomodulator, has been well documented in immunotherapy to tumor. however, severe side effects, such as intrahepatic granulomas and scleromas in injected areas, restrict its clinical application. to minimize side effects of cp, a non-cell corynebacterium parvum product (ncpp) was prepared by disposing cp with nanotechnology. in present study, we compared effect of ncpp with that of cp and found: (1) ncpp with non-formaldehyde residue was easy to be absor ... | 2007 | 17673148 |
| modulation of integrins and filaggrin expression by propionibacterium acnes extracts on keratinocytes. | propionibacterium acnes plays an important role in the pathogenesis of acne and it is established that this bacteria is involved in the induction and maintenance of the inflammatory phase of acne. the aim of our work was to determine if p. acnes extracts could modulate integrins and filaggrin in vitro expression by keratinocytes. integrins and filaggrin expression was examined using immunohistochemistry technique both on normal human epiderminal keratinocytes (nhek) and on deep-frozen sections o ... | 2007 | 17684752 |
| propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. | we have established an in vitro immunization protocol whereby human peripheral blood mononuclear cells (pbmcs) are initially treated with l-leucyl-l-leucine methyl ester (llme) and subsequently sensitized with antigen in the presence of interleukin (il)-2, il-4, and adjuvant. this protocol resulted in the production of antigen-specific antibodies. pbmcs are potentiated to react with exogenous antigens upon treatment with llme. we are using this system to investigate the immunomodulatory activity ... | 2007 | 17690460 |
| microcalorimetry: a novel method for detection of microbial contamination in platelet products. | measuring heat from replicating microorganisms in culture may be a rapid, accurate, and simple screening method for platelets (plts). microcalorimetry for detection of microorganisms in in vitro contaminated plt products was evaluated. | 2007 | 17725729 |
| combination of a new radiofrequency device and blue light for the treatment of acne vulgaris. | acne vulgaris is the most common skin disease treated by physicians. current topical and oral treatments may have short- and long-term negative consequences. since radiofrequency (rf) energy has been shown to reduce sebum production and 410-nm blue light has been shown to kill propionibacterium acnes (p. acnes) cells, these modalities in combination should be a highly effective treatment of acne vulgaris with little or no downtime or risk. this case report describes the efficacy and safety of rf ... | 2007 | 17763617 |
| microbial contamination of bm products before and after processing: a report of incidence and immediate adverse events in 257 grafts. | the incidence and potential clinical consequences of bacterial contamination of autologous and allogeneic bm products remains open to question. we report our experience of bacterial contamination of bm grafts and adverse events that occurred after transplantation. | 2007 | 17786612 |
| the impact and importance of resistance. | bacterial resistance to antibiotics began to emerge soon after their introduction. beginning in the 1970s, propionibacterium acnes also began to show decreased sensitivity to the antibiotics typically used in acne management. clinically, this trend has translated to decreased efficacy and even nonresponse to therapy. a variety of recommendations regarding optimum use of antibiotics in acne management have been developed to preserve the utility of these drugs. most important is the use of combina ... | 2007 | 17824580 |
| community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne. | acne is characterized by different types of lesions at different stages of development. therefore, combination therapy may offer numerous advantages, including enhanced efficacy and better tolerability. the addition of benzoyl peroxide (bpo) to all long-term antibiotic treatment is widely advocated to help suppress the emergence of antibiotic-resistant bacteria. topical retinoids are recommended as early initiation treatment of most patients with acne because they target most mechanisms of acne ... | 2007 | 17824581 |
| tumor microenvironment: hypoxia and buffer capacity for immunotherapy. | in recent years, significant progress has been made in the study of tumor biology and anti-tumor immunotherapy. however, the cellular and molecular mechanisms of tumor progression still remain obscure. as we know, tumor microenvironment that can directly influence tumor development and prognosis has attracted much attention of large number of immunologists. accumulated evidence has suggested that tumor microenvironment is in a hypoxic condition, under which immune cells may exhibit distinct func ... | 2007 | 17360127 |
| il-3 is an important differentiation factor for the development of prostaglandin e2-producing macrophages between c57bl/6 and balb/c mice. | we have previously reported that peritoneal and splenic macrophages from th2-dominant balb/c mice produced higher amounts of prostaglandin (pg) e2 than cells from c57bl/6 mice. in this study, we investigated how macrophages from balb/c mice acquire the ability of enhanced pge2 production, using bone marrow-derived macrophages differentiated by m-csf, gm-csf or il-3. there is no strain difference in pge2 production by gm-csf- and m-csf-differentiated macrophages; however, il-3-differentiated macr ... | 2007 | 17628861 |
| bacterial contamination of platelet concentrates: results of a prospective multicenter study comparing pooled whole blood-derived platelets and apheresis platelets. | the germs group initiated a prospective multicenter study to assess prevalence and nature of bacterial contamination of pooled buffy-coat platelet concentrates (ppcs) and apheresis platelet concentrates (apcs) by routine screening with a bacterial culture system. | 2007 | 17381623 |
| propionibacterium acnes endocarditis in an adolescent boy suffering from a congenital cardiopathy. | propionibacterium acnes endocarditis is an uncommon infection in pediatrics. we describe a case of p. acnes endocarditis in a 16-year-old boy that occurred 6 months after recurrent surgery for a congenital cardiopathy. molecular identification of p. acnes was obtained. he recovered from this infection after a surgical treatment and with a prolonged antibiotic regimen including ceftriaxone. | 2007 | 17721389 |
| acne and risk of prostate cancer. | in a recent study, prostatectomy specimens from which propionibacterium acnes was cultured were more likely to have inflammation than culture-negative specimens or specimens positive for other bacteria, leading the authors to hypothesize that p. acnes-mediated inflammation may contribute to prostate carcinogenesis. to indirectly explore associations between p. acnes and prostate cancer, we investigated severe acne, as measured by tetracycline use for 4 or more years, in relation to incident pros ... | 2007 | 17724724 |
| cardiac magnetic resonance imaging for detection of an abscess associated with prosthetic valve endocarditis: a case report. | propionibacterium acnes is an organism frequently isolated in cultures and often dismissed as a contaminant. a patient with a febrile illness and prosthetic aortic valve was suspected of having infectious endocarditis. magnetic resonance imaging was useful in defining a paravalvular abscess associated with prosthetic valve endocarditis due to propionibacterium acnes that was then successfully surgically repaired. | 2007 | 17389206 |
| biofilm formation by propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors. | propionibacterium acnes plays an important role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles. recently, it was suggested that p. acnes cells residing within the follicles grow as a biofilm. in the present study, we tested the biofilm-forming ability of several p. acnes strains in a microtiter plate model. we also evaluated the resistance of biofilm-grown p. acnes towards antimicrobial agents commonly used in the treatment of acne and the production of pu ... | 2007 | 17399956 |
| genome sequence and analysis of a propionibacterium acnes bacteriophage. | cutaneous propionibacteria are important commensals of human skin and are implicated in a wide range of opportunistic infections. propionibacterium acnes is also associated with inflammatory acne vulgaris. bacteriophage pa6 is the first phage of p. acnes to be sequenced and demonstrates a high degree of similarity to many mycobacteriophages both morphologically and genetically. pa6 possesses an icosahedreal head and long noncontractile tail characteristic of the siphoviridae. the overall genome ... | 2007 | 17400737 |
| acute bilateral diffuse corneal opacity in a child. | to report a case of acute bilateral corneal opacity related to bacterial blepharoconjunctivitis. | 2007 | 17413971 |
| propionibacterium acnes: an agent of prosthetic joint infection and colonization. | prosthetic joint infection (pji) can present a diagnostic challenge, especially with slow-growing and poorly virulent bacteria. | 2007 | 17418419 |
| acute deep infection after surgical fixation of proximal humeral fractures. | acute deep infection after open reduction-internal fixation of proximal humeral fractures is uncommon. currently, there are no reported series on the outcomes of patients treated for infection after surgery for proximal humeral fractures. the purpose of this study was to review the frequency, clinical presentation, bacteriology, treatment, and outcomes of patients with such fractures complicated by acute deep infection. between 1993 and 2003, 5 patients with acute deep infection after open reduc ... | 2007 | 17448697 |
| [preoperatively administered flomoxef sodium concentration in aqueous humor]. | we intravenously administered flomoxef sodium (fmox) 0.5-3.5 hours before cataract surgery and measured the concentration of the agent in the aqueous humor to investigate its penetration into the aqueous humor and its efficacy in the prevention of postoperative endophthalmitis. | 2007 | 17461038 |
| intravenous administration of mip-1alpha with intra-tumor injection of p. acnes shows potent anti-tumor effect. | dendritic cells (dcs) play a key role as potent biological adjuvants in anti-tumor host responses. however, dc-based vaccination does not always eradicate tumors effectively. clinical evidence suggests that a strategy to recruit a substantial number of dcs into the tumor mass might provoke proficient anti-tumor immune responses. here we describe that myeloid dcs (mdcs) efficiently accumulate in tumor sites after intravenous injection of recombinant macrophage inflammatory protein (mip)-1alpha wh ... | 2007 | 17466918 |
| propionibacterium acnes: an under-appreciated cause of post-neurosurgical infection. | propionibacterium acnes is increasingly recognized as a cause of post-neurosurgical infection. this review of patients with p. acnes neurosurgical infection was carried out in order to determine clinical characteristics and outcomes in relation to duration of antimicrobial treatment. | 2007 | 17875606 |
| propionibacterium acnes vertebral osteomyelitis: seek and ye shall find? | the pathogenic potential of propionibacterium acnes in implant-associated spine infections is increasingly recognized. however, the clinical findings and outcomes associated with this pathogen in nonimplant-associated spine infections are unknown. we retrospectively reviewed nine male patients who met our strict case definition for p. acnes vertebral osteomyelitis to determine whether the laboratory, radiographic, and histopathology found in these infections differs from that typically associate ... | 2007 | 17483730 |
| breast abscess bacteriologic features in the era of community-acquired methicillin-resistant staphylococcus aureus epidemics. | increasing rates of community-acquired methicillin-resistant staphylococcus aureus (mrsa) infections have also affected the microbial profile of breast abscesses. | 2007 | 17891866 |
| analysis of anaerobic blood cultures in burned patients. | the utility of anaerobic blood culturing is often debated in the general population, but there is limited data on the modern incidence, microbiology, and utility of obtaining routine anaerobic blood cultures for burned patients. we performed a retrospective review of the burned patients electronic medical records database for all blood cultures drawn between january 1997 and september 2005. we assessed blood cultures for positivity, organisms identified, and growth in aerobic or anaerobic media. ... | 2007 | 17493763 |
| the c/ebp beta isoform 34-kda lap is responsible for nf-il-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. | the c/ebpb gene is translated into three different protein isoforms, two transcriptional activating proteins (38-kda full and 34-kda liver-enriched transcriptional activation protein (lap)) and one transcriptional inhibitory protein, by alternative use of different aug initiation codons within the same open reading frame. the isoform 34-kda lap is thought to be the most transcriptionally active form of c/ebpbeta in macrophages. to assess the function of the 34-kda lap in vivo, we generated knock ... | 2007 | 17911624 |
| propionibacterium acnes contamination in lumbar disc surgery. | previous studies have shown that propionibacterium acnes may be responsible for low-grade infection of the intervertebral discs of patients with severe sciatica. the aim of this study was to prospectively investigate the presence of bacteria in disc fragment samples obtained during surgery for lumbar disc herniation. p. acnes was cultured from disc fragments in two (3.7%) of 54 patients studied. in addition, control cultures taken from ligamentum flavum and muscle from these two patients were al ... | 2007 | 17573158 |
| activity of the novel macrolide bal19403 against ribosomes from erythromycin-resistant propionibacterium acnes. | bal19403 is a macrolide antibiotic from a novel structural class with potent activity against propionibacteria in vitro. the antibacterial spectrum of bal19403 covers clinical isolates with mutations in the 2057 to 2059 region of 23s rrna that confer resistance to erythromycin and clindamycin. the basis of this improved activity was investigated by ribosome binding assays and by a coupled transcription and translation assay. the latter was specifically developed for the use of ribosomes from pro ... | 2007 | 17923495 |
| photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. | acne vulgaris does not always respond to conventional therapy. photodynamic therapy (pdt) has been proposed as a treatment option. the aim of this study was to determine the optimal light dose for effective pdt treatment of acne and to investigate whether pdt reduces sebum excretion and the amount of propionibacterium acnes. fifteen patients (9 men, 6 women, age range 16-44 years, mean age 25 years) with mild to severe acne were enrolled in an open, unblinded study. aminolaevulinic acid cream (2 ... | 2007 | 17598035 |
| bacterial reduction in infected root canals treated with 2.5% naocl as an irrigant and calcium hydroxide/camphorated paramonochlorophenol paste as an intracanal dressing. | this clinical study investigated the bacterial reduction after instrumentation using 2.5% sodium hypochlorite (naocl) as an irrigant and further interappointment dressing with a calcium hydroxide (ca(oh)(2))/camphorated paramonochlorophenol (cpmc) paste. eleven teeth with primary intraradicular infections and chronic apical periodontitis selected according to stringent inclusion/exclusion criteria followed in the study. bacterial samples were taken before treatment (s1), after chemomechanical pr ... | 2007 | 17509403 |
| wound contamination in cardiac surgery. a systematic quantitative and qualitative study of the bacterial growth in sternal wounds in cardiac surgery patients. | to investigate the degree of bacterial contamination in the sternal wound during cardiac surgery and the sternal skin flora after operation in order to increase our understanding of the pathogenesis of sternal wound infections. | 2007 | 17931237 |
| propionibacterium acnes and sapho syndrome: a case report and literature review. | to describe the presence of propionibacterium acnes (p. acnes) in a series of patients with sapho syndrome in which a bone biopsy has been carried out and to discuss the results comparing them to the data described in the literature. | 2007 | 17631745 |
| relation between mental stress-induced prefrontal cortex activity and skin conditions: a near-infrared spectroscopy study. | although psychological stress affects skin condition, the neurophysiological mechanism involved is unclear. in this study, we evaluated the relationship between skin condition and left/right asymmetry in prefrontal cortex (pfc) activity during mental stress tasks since recent studies have suggested that the right pfc dominates the regulation of the stress response system, including the hypothalamic-pituitary-adrenal (hpa) axis. using near-infrared spectroscopy, we measured hemoglobin concentrati ... | 2007 | 17950258 |
| temporal changes in sebum excretion and propionibacterial colonization in preadolescent children with and without acne. | it is generally accepted that the onset of sebum secretion occurs before puberty in boys and girls as a result of increasing androgen output during the adrenarche. propionibacteria are part of the commensal skin flora and, in adults, are found in highest numbers in sebum-rich areas of skin such as the face and upper trunk. previous studies investigating the association between sebum output and propionibacterial population densities have been cross-sectional and have been carried out mainly in ad ... | 2007 | 17199562 |
| activities of four frog skin-derived antimicrobial peptides (temporin-1dra, temporin-1va and the melittin-related peptides ar-23 and rv-23) against anaerobic bacteria. | the activities of two antimicrobial peptides belonging to the temporin family (temporin-1dra from rana draytonii and temporin-1va from rana virgatipes) and two peptides with structural similarity to the bee venom peptide melittin (ar-23 from rana tagoi and rv-23 from r. draytonii) were evaluated against a range of reference strains and clinical isolates of anaerobic bacteria. these peptides were selected because they show broad-spectrum growth inhibitory activity against reference strains of sev ... | 2007 | 17196372 |
| incidence, microbiological findings, and clinical presentation of sternal wound infections after cardiac surgery with and without local gentamicin prophylaxis. | sternal wound infection (swi) is a serious complication after cardiac surgery. in a previous randomized controlled trial, the addition of local collagen-gentamicin in the sternal wound before wound closure was found to significantly reduce the incidence of postoperative wound infections compared with the routine intravenous prophylaxis of isoxazolyl-penicillin only. the aims of the present study were to analyse the microbiological findings of the swis from the previous trial as well as to correl ... | 2007 | 17211605 |
| biofilm formation by bacteria isolated from retrieved failed prosthetic hip implants in an in vitro model of hip arthroplasty antibiotic prophylaxis. | bacterial infection primarily with staphylococcus spp. and propionibacterium acnes remains a significant complication following total hip replacement. in this in vitro study, we investigated the efficacy of gentamicin loading of bone cement and pre- and postoperative administration of cefuroxime in the prevention of biofilm formation by clinical isolates. high and low initial inocula, representative of the number of bacteria that may be present at the operative site as a result of overt infectio ... | 2007 | 17001707 |
| resolution of inflammatory acne vulgaris may involve regulation of cd4+ t-cell responses to propionibacterium acnes. | propionibacterium acnes has been strongly implicated in inflammatory acne. however, its role in the disease is unclear. it has been hypothesized that an immune response to p. acnes and/or p. acnes heat shock proteins (hsps) may play a role in the pathogenesis of inflammatory acne. | 2007 | 17300234 |
| in vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections. | retapamulin is the first agent of the pleuromutilin class formulated as a topical antibacterial for treating skin infections. the aim of this study was to determine the antimicrobial activity of retapamulin by determining the minimal inhibitory concentration (mic) values of this new drug and comparators against a wide range of anaerobic bacteria of human origin. | 2007 | 17350985 |
| transfer of bacteria between biomaterials surfaces in the operating room--an experimental study. | bacterial adhesion to and transfer between surfaces is a complicated process. with regard to the success of biomaterials implants, studies on bacterial adhesion and transfer should not be confined to biomaterials surfaces in the human body, but also encompass surfaces in the operating room, where the origin of many biomaterials related infections is found. the purpose of this study was to quantify the transfer of staphylococcus aureus, staphylococcus epidermidis, and propionibacterium acnes from ... | 2007 | 17058211 |
| propionibacterium acnes as a cause of prosthetic valve aortic root abscess. | propionibacterium acnes isolates usually have relatively low virulence and are often classified as contaminants when isolated from blood and tissue cultures. we report a patient with propionibacterium acnes bacteremia and late prosthetic valve endocarditis, complicated by an aortic root abscess. | 2007 | 17065271 |
| blue and red light combination led phototherapy for acne vulgaris in patients with skin phototype iv. | blue light is effective for acne treatment, inducing photodynamic destruction of propionibacterium acnes (p. acnes). this study was designed to investigate the efficacy of combined blue and red light-emitting diode (led) phototherapy for acne vulgaris. | 2007 | 17111415 |
| memory cd4 t cells enhance primary cd8 t-cell responses. | cd4 t-cell help is required for optimal memory cd8 t-cell responses. we have found that engaging preexisting cd4 th1, but not th2, memory cells at the time of cd8 t-cell priming results in increased cd8 effector responses to both bacterial and viral pathogens. the enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. these findings suggest that engaging endogenous memory th1 cells may increase cellular responses in an immunotherapy or vaccinatio ... | 2007 | 17438031 |
| resveratrol inhibition of propionibacterium acnes. | to evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on propionibacterium acnes growth. | 2007 | 17449884 |
| biofilm formation by propionibacterium acnes on biomaterials in vitro and in vivo: impact on diagnosis and treatment. | propionibacterium acnes is found increasingly as a cause of delayed infection, usually involving implanted biomaterials. despite susceptibility to common antibiotics, such infections are very difficult to treat and usually require surgical removal of the device. three clinical isolates of p. acnes were assessed for ability to adhere to titanium, surgical steel and silicone, with and without a plasma conditioning film. after adherence, the biomaterials were then incubated for a further 6 days and ... | 2007 | 17187384 |
| screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. | there is cumulative resistance against antibiotics of many bacteria. therefore, the development of new antiseptics and antimicrobial agents for the treatment of skin infections is of increasing interest. we have screened six plant extracts and isolated compounds for antimicrobial effects on bacteria and yeasts with dermatological relevance. the following plant extracts have been tested: gentiana lutea, harpagophytum procumbens, boswellia serrata (dry extracts), usnea barbata, rosmarinus officina ... | 2007 | 17291738 |
| effect of amodiaquine, a histamine n-methyltransferase inhibitor, on, propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. | we examined whether treatment with amodiaquine, a potent inhibitor of histamine n-methyltransferase protects mice from propionibacterium acnes (p. acnes)-primed and lipopolysaccharide (lps)-induced hepatitis. the subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice. pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with t ... | 2007 | 17222819 |
| progressive macular hypomelanosis: an overview. | progressive macular hypomelanosis (pmh) is a common skin disorder that is often misdiagnosed. various authors have written about similar skin disorders, referring to them by different names, but we believe that all these similar disorders are part of the same entity.pmh is characterized by ill-defined nummular, non-scaly hypopigmented spots on the trunk, often confluent in and around the midline, and rarely extending to the proximal extremities and neck/head region. there is no itch, pain, or pr ... | 2007 | 17298102 |
| induction of serum il-18 with propionibacterium acnes and lipopolysaccharide in phagocytic macrophage-inactivated mice. | il-18, an important regulator of immune responses, is expressed in activated macrophages and also in nonimmune cells, such as keratinocytes and epithelial cells. increased levels of serum il-18 are reported in patients with a wide variety of diseases, but it is unclear which type of cell is the major source of serum il-18. here, we showed that the administration of liposomes encapsulating clodronate (clo-lip) in mice selectively depleted f4/80(+) phagocytic macrophages in the liver and spleen. s ... | 2007 | 17522234 |
| role of bacterial and host factors in infectious endophthalmitis. | endophthalmitis is a frequent blinding complication of globe-penetrating injury and ocular surgery. the outcome of this intraocular infection depends both on the organism involved and management of the ensuing inflammation. the role of various toxins and bacterial factors in the pathogenesis of this infection is beginning to be delineated, but appears to be organism specific. because of the immune-privileged environment of the eye, principles important in the resolution of infection at extraocul ... | 2007 | 17264502 |
| clinical and microbiological comparisons of isotretinoin vs. tetracycline in acne vulgaris. | the aim of this study was to compare the clinical and microbiological effect on propionibacterium acnes of oral tetracycline plus topical adapalene vs. oral isotretinoin in moderate to severe acne vulgaris. male and female acne patients with moderate or severe inflammatory disease were enrolled and assigned randomly to 6 months of treatment with oral tetracycline hydrochloride plus topical adapalene, or oral isotretinoin, in a controlled, open study. after cessation of oral treatment the antibio ... | 2007 | 17533492 |
| postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures. | postoperative central nervous system infection (pcnsi) in patients undergoing neurosurgical procedures represents a serious problem that requires immediate attention. pcnsi most commonly manifests as meningitis, subdural empyema, and/or brain abscess. recent studies (which have included a minimum of 1000 operations) have reported that the incidence of pcnsi after neurosurgical procedures is 5%-7%, and many physicians believe that the true incidence is even higher. to address this issue, we exami ... | 2007 | 17554701 |
| type 1 cytokine/chemokine production by mouse nk cells following activation of their tlr/myd88-mediated pathways. | it is well established that il-18r- and toll-like receptor (tlr)-mediated signalings share a common signal pathway mediated by signal adaptor, myd88, and that il-18 synergizes with il-12 for ifn-gamma production by nk cells. here, we investigated whether tlr agonists can replace il-18 for production of ifn-gamma by nk cells. freshly isolated nk cells possessed functional lps receptor composed of tlr4/md2 complex and of cd14, and also expressed other various tlrs. hepatic cd3(-)dx5(+) nk cells pr ... | 2007 | 17289654 |
| prevention of transfusion of platelet components contaminated with low levels of bacteria: a comparison of bacteria culture and pathogen inactivation methods. | this study compared the efficacy of bacterial detection with inactivation for reducing the risk associated with transfusion of platelet (plt) components contaminated with low levels of bacteria. | 2007 | 17581146 |
| valuable lessons from sapho syndrome. | 2007 | 17347017 | |
| [anti-microbial therapies for acne vulgaris: anti-inflammatory actions of anti-microbial drugs and their effectiveness]. | the etiology of acne vulgaris is complicated and characterized by two aspects, non-inflammatory and inflammatory mechanisms. the non-inflammatory aspect is represented by follicular occlusion by sebaceous materials and resultant formation of comedo. on the other hand, acne features the continuing occurrence of inflammation, which yields reddish popular or nodular lesions. therefore, acne is not a simple infection with propionibacterium acnes, but subsequent inflammatory changes are the nature of ... | 2007 | 17380730 |
| genetic homogeneity/heterogeneity of propionibacterium acnes isolated from patients during cardiothoracic reoperation. | following cardiothoracic surgery, deep sternal wound infection (swi) remains one of the most severe complications. recently, propionibacterium acnes has been suspected as an etiological agent of deep swi. however, this bacterium constitutes part of the resident micro-flora of the human skin. consequently, findings of p. acnes in invasive samples are difficult to value. the aims of this study were to develop and optimize a pulsed-field gel electrophoresis (pfge) protocol for p. acnes, in order to ... | 2007 | 17512224 |
| in vitro modulation of tlr-2, cd1d and il-10 by adapalene on normal human skin and acne inflammatory lesions. | the anti-inflammatory mechanisms of adapalene, a synthetic retinoid used for the treatment of acne patients, are partially understood. they seem particularly related to the modulation of the non-specific immunity. recent studies have shown that toll-like receptor (tlr)-2 expression, a receptor of the innate immune system, was increased in acne lesions and could play an essential role in acne-linked inflammation. the aim of our study was to investigate the new mechanisms of the anti-inflammatory ... | 2007 | 17518990 |
| modulatory effect of killed propionibacterium acnes and its purified soluble polysaccharide on peritoneal exudate cells from c57bl/6 mice: major nkt cell recruitment and increased cytotoxicity. | propionibacterium acnes has been described as a potent adjuvant to immune responses in vitro and in vivo. presently, we analysed the modulation of peritoneal exudate cells (pec) by heat-killed p. acnes or its purified soluble polysaccharide (ps), both injected intraperitoneally in c57bl/6 mice, aiming at their recruitment and cytotoxicity. both treatments induced an increase in macrophages, immature dendritic cells, b1a lymphocytes and nk1.1(+) cd3(+) cells. the bacterium caused a remarkable inc ... | 2007 | 17523946 |
| microbiology of acute sinusitis of odontogenic origin presenting with periorbital cellulitis in children. | this study was undertaken to evaluate the aerobic and anaerobic microbiology of acute maxillary sinusitis of odontogenic origin presenting with periodontal infection in children. | 2007 | 17561769 |
| linkage between toll-like receptor (tlr) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis. | the intracellular pathogens propionibacterium acnes and mycobacterium tuberculosis have been leading suspects as the cause of sarcoidosis, a systemic disorder characterized by the formation of non-caseating granulomas. toll-like receptor (tlr) 2 is important in the innate immune response against both pathogens, and is therefore of interest in sarcoidosis research. in the present study, three single nucleotide polymorphisms and one dinucleotide repeat polymorphism in the tlr-2 gene were genotyped ... | 2007 | 17565608 |
| clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: focus on antibiotic resistance. | propionibacterium acnes is an anaerobic bacterium that plays an important role in the pathogenesis of acne. certain antibiotics that can inhibit p acnes colonization also have demonstrated anti-inflammatory activities in the treatment of acne, rosacea, and other noninfectious diseases. decreased sensitivity of p acnes to antibiotics, such as erythromycin and tetracycline, has developed and may be associated with therapeutic failure. benzoyl peroxide (bpo) is a nonantibiotic antibacterial agent t ... | 2007 | 17649854 |
| community-based study of acne vulgaris in adolescents in singapore. | there are few studies on the prevalence of acne vulgaris among asian teenagers. | 2007 | 17655737 |
| acute dehiscence of a valve prosthesis 5 years after implantation. | propionibacterium acnes, a common human skin organism [perry a.l., lambert p.a., under the microscope propionibacterium acnes, lett app microbiol 2006; 42:185-186], mostly considered a contaminant, has rarely been associated with cases of infectious endocarditis [vanagt w.y., daenen w.j., delhaas t., propionibacterium acnes endocarditis on an annuloplasty ring in an adolescent boy, heart 2004; 90:56]. we report on a 48-year old man with a history of mitral valve replacement who acutely developed ... | 2007 | 17320207 |
| deep infection after rotator cuff repair. | currently, there is little information available concerning the outcome of patients with infection after rotator cuff repair. the purpose of this study was to review retrospectively the incidence, clinical presentation, bacteriology, treatment, and outcomes of patients with rotator cuff repair complicated by deep infection. between 1975 and 2003, 39 cases of deep infection after rotator cuff repair were identified in 38 patients. at a final follow-up of 8.2 years (range, 30 months to 19.8 years) ... | 2007 | 17321157 |
| the propionibacterium acnes genome: from the laboratory to the clinic. | the genome of propionibacterium acnes, the microbe presumed to be at least partially etiologic for the development of acne, has recently been decoded. the genome supports long-standing concepts regarding acne pathogenesis, but also demonstrates heretofore unknown and/or unsuspected bacterial properties, which might play a role in disease occurrence. in turn, understanding the genome may lead to new therapeutic avenues, as summarized in this manuscript. | 2007 | 17668523 |
| study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris. | combination therapy is the standard of care in the management of acne vulgaris. it is essential to treat as many aspects of acne pathogenesis as possible. due to increasing insensitivity of propionibacterium acnes to antibiotics, the concomitant use of other topical agents that exhibit other modes of antibacterial and anti-inflammatory activity is integral to the successful treatment of acne. the combination of topical benzoyl peroxide and clindamycin gel has been shown to be more effective than ... | 2007 | 17668527 |
| effect of adjunctive treatment with intravenously administered propionibacterium acnes on reproductive performance in mares with persistent endometritis. | to determine whether treatment with a preparation of propionibacterium acnes would improve pregnancy and live foal rates in mares with persistent endometritis. | 2007 | 17605673 |
| inhibitors of dipeptidyl peptidase iv and aminopeptidase n target major pathogenetic steps in acne initiation. | acne is a chronic disease hallmarked by sebaceous hyperplasia, follicular hyperkeratosis, and inflammation. parallel targeting of these factors is required to treat acne effectively. inhibitors of dipeptidyl peptidase iv (dp iv) and aminopeptidase n (apn) show strong anti-inflammatory effects on immune cells and therapeutic efficacy in autoimmune disorders. our investigation focused on the expression and functional relevance of these ectopeptidases in three cell types which exhibit an altered ph ... | 2007 | 16778789 |
| isolation of aminopeptidase n genes of food associated propionibacteria and observation of their transcription in skim milk and acid whey. | in this study consensus oligonucleotides pn5/pn3 were designed by aligning the aminopeptidase n genes (pepn) of various actinobacteria and applied to the isolation of the pepn genes of dairy propionibacteria (pab) and closely related species associated with food. this allowed sequencing of a pepn gene region from propionibacterium jensenii lmg 16541. the sequence of this gene was completed by inverse pcr. consensus primer pairs nu1/d1 and nu2/d1 were derived from the alignment of the new sequenc ... | 2007 | 17013549 |
| anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. | lipids are important constituents of the human epidermis. either free and organized into broad lipid bilayers in the intercorneocytes spaces, or covalently bound to the corneocyte envelope, they play a crucial role in permeability barrier function and are major contributors to cutaneous anti-microbial defense. free sphingoid bases are a recent addition to this family of active lipids, which emerged from studies of breakdown products from ceramides. phytosphingosine (ps) is a lipid occurring natu ... | 2007 | 18489348 |
| linoleic acid isomerase from propionibacterium acnes: purification, characterization, molecular cloning, and heterologous expression. | propionibacterium acnes strain atcc 6919 catalyzes the isomerization of the double bond at the c9 position in linoleic acid (c9,c12, 18:2) to form t10,c12 conjugated linoleic acid (cla, 18:2). cla has significant health benefits in animal and human. the linoleic acid c9 isomerase was purified to an apparent homogeneity by successive chromatography on diethylaminoethyl (deae) anion exchange, hydrophobic interaction, and chromatofocusing columns. two degenerated oligonucleotide primers were synthe ... | 2007 | 18057448 |
| sarcoidosis-like reaction related to propionibacterium acnes and immune restoration syndrome in hiv infection . | propionibacterium acnes is thought to be a potential triggering agent of sarcoidosis. we describe a woman who developed chronic meningitis with sarcoid-like multisystemic involvement under treatment for human immunodeficiency virus infection. p. acnes was isolated from cerebrospinal fluid. we assume that p. acnes might have triggered this sarcoid-like reaction with meningitis, as a consequence of an immune reconstitution. | 2007 | 18061967 |
| laser treatment of acne vulgaris. | traditional medical treatments for acne vulgaris include a variety of topical and oral medications. the combination of poor compliance, lack of durable remission, and potential side effects are common drawbacks to these treatments. the use of lasers and light devices has increased dramatically in recent years due to the overall ease of treatment, predictable clinical efficacy, and minimal adverse effects. a variety of light and laser devices has been used for the treatment of acne, including the ... | 2007 | 20567668 |
| biological activities of schefflera leucantha. | this study investigated various biological activities of the ethanolic extract of dried ground leaves of schefflera leucantha viguier (araliaceae). the extract possessed very low cytotoxicity to brine-shrimp with the lc(50) of 4,111.15 microg/ml; the significant antioxidant activity on dpph with the ec(50) of 71.90 microg/ml; the inhibitory activity on mushroom tyrosinase with the ic(50) of 10.53 mg/ml using the dopachrome microplate-assay. the extract of 5-20 mg/ml range in the agar dilution as ... | 2006 | 20162087 |
| treatment of active acne with an er:glass (1.54 microm) laser: a 2-year follow-up study. | to investigate the effects of the 1.54 microm wavelength on active lesions of the face and of the back at the 2-year follow-up. | 2006 | 19839169 |
| evaluation of in vitro antimicrobial activity of thai basil oils and their micro-emulsion formulas against propionibacterium acnes. | the aim of this study was to evaluate the efficacy of thai basil oils and their micro-emulsions, on in vitro activity against propionibacterium acnes. an agar disc diffusion method was employed for screening antimicrobial activity of the essential oils of ocimum basilicum l. (sweet basil), ocimum sanctum l. (holy basil) and ocimum americanum l. (hoary basil) against p. acnes. minimum inhibitory concentration (mic) values of the basil oils were determined using an agar dilution assay. the obtaine ... | 2006 | 18492147 |
| treatment considerations for inflammatory acne: clinical evidence for adapalene 0.1% in combination therapies. | acne vulgaris is an exceptionally common, chronic, and recurring disease. it involves multiple etiological factors including follicular hyperkeratinization, increased sebum production, propionibacterium acnes proliferation, and inflammation. presently, oral isotretinoin is the only single agent that is effective against all 4 major pathophysiologic features. however, this drug is also responsible for several serious side effects, including teratogenicity. therefore, it should be used in only the ... | 2006 | 16989194 |
| [the effect of preoperative topical antibiotics in cataract surgery]. | we studied whether topical antibiotics prevent endophthalmitis after cataract surgery. | 2006 | 16884070 |
| a multicenter efficacy and tolerability evaluation of benzoyl peroxide in a 10% urea vehicle for the treatment of acne vulgaris. | acne vulgaris is a common skin disease that affects 70 to 96% of individuals. topical benzoyl peroxide has been used successfully for acne treatment; however, it may be accompanied by drying and or flaking skin. the addition of a 10% urea to the product excipient is theorized to moisturize the skin due to its humectant properties, aid in the efficacy of benzoyl peroxide due to its keratolytic properties, and effectively combat propionibacterium acnes due to its antibacterial properties. | 2006 | 16703780 |
| elimination and multiplication of bacteria during preparation and storage of buffy coat-derived platelet concentrates. | the prevalence of bacterial contamination of random-donor platelet concentrates (pcs) is considerably lower than that of blood donations. which key steps of the preparation procedure contribute to the elimination of bacteria was investigated. | 2006 | 16734811 |
| role of intravitreal triamcinolone acetonide in the treatment of postoperative endophthalmitis. | to report the use of commercially available triamcinolone acetonide as adjunct treatment for acute-onset endophthalmitis after intraocular procedures. | 2006 | 16770261 |
| susceptibilities of propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime. | we investigated the in vitro susceptibilities of 23 propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the etest. the mics ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1.5 microg/ml, and 1 microg/ml to 12 microg/ml for ertapenem, meropenem, and cefepime, respectively. based on our excellent in vitro carbapenem susceptibility results, in vivo studies using ertapenem and meropenem in a rabbit model of p. acnes endophthalmitis are war ... | 2006 | 16971643 |
| sarcoidosis and nod1 variation with impaired recognition of intracellular propionibacterium acnes. | sarcoidosis is a systemic granulomatous disease of unknown etiology. nod2 mutations have been shown to predispose to granulomatous diseases, including crohn's disease, blau syndrome, and early-onset sarcoidosis, but not to adult sarcoidosis. we found that intracellular propionibacterium acnes, a possible causative agent of sarcoidosis, activated nf-kappab in both nod1- and nod2-dependent manners. systematic search for nod1 gene polymorphisms in japanese sarcoidosis patients identified two allele ... | 2006 | 16935475 |
| outbreak of postoperative shoulder arthritis due to propionibacterium acnes infection in nondebilitated patients. | we investigated an outbreak of postoperative shoulder arthritis due to propionibacterium acnes infection in nondebilitated patients. risk factors were male sex, the order in which surgery was performed during the daily operating schedule, and increased duration of the surgical procedure. after modification of the ventilation system and implementation of improved cleaning methods in the operating theater, no new cases were recorded. | 2006 | 16941330 |
| investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris. | nonablative lasers are widely used for treatment of wrinkles, atrophic scars and acne. these lasers stimulate dermal remodelling and collagen production, but the early molecular stimulus for this is unknown. the mechanism of nonablative lasers in inflammatory acne is variously suggested to be damage either to sebaceous glands or to propionibacterium acnes. their effects on cytokine production are unknown. | 2006 | 16965424 |
| polymerase chain reaction-based identification of propionibacterium acnes types isolated from the male urinary tract: evaluation of adolescents, normal adults and men with prostatic pathology. | to assess whether colonization of the male urinary tract with propionibacterium acnes, in particular types ib and ii (which are associated with inflammation in radical prostatectomy specimens and might be involved in the development of prostate cancer), is associated with prostate disease, and thus to develop a urine test to detect men at risk of prostate disease. | 2006 | 16879683 |
| essential roles of dc-derived il-15 as a mediator of inflammatory responses in vivo. | interleukin (il)-15 is expressed in a variety of inflammatory diseases. however, the contribution of dendritic cell (dc)-derived il-15 to the development of diseases is uncertain. using established models of propionibacterium acnes (p. acnes)- and zymosan-induced liver inflammation, we observed granuloma formation in the livers of wild-type (wt) and rag-2(-/-) mice but not in those of il-15(-/-) mice. we demonstrate that this is likely caused by an impaired sequential induction of il-12, ifn-gam ... | 2006 | 16966429 |
| association between the presence of bacterial 16s rna in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (sweden). | to study bacterial 16s rna in archival prostate samples from 352 patients with benign prostate hyperplasia (bph) and evaluate whether the presence of bacterial dna was different in those who later developed prostate cancer (n = 171) and in the matched controls that did not progress to cancer (n = 181). | 2006 | 17006718 |
| [biotyping of propionibacterium acnes strains isolated from patients with acne vulgaris]. | propionibacterium acnes is the main bacterial etiologic agent in acne vulgaris pathogenesis. the rate of antibiotic resistant p. acnes isolates is less than 10% in our country. the aim of this study was to biotype p. acnes strains which were isolated from acne vulgaris patients and to investigate the biotype distribution in our region. p. acnes isolates from 64 patients (18 male, 46 female; mean age 19 +/- 3.1 years) were included in the study and biotyped by sugar-specific ph changes using sorb ... | 2006 | 16775952 |
| infections associated with orthopedic implants. | we review recent advances in the prevention, diagnosis and treatment of infections associated with joint prostheses and internal fixation devices. | 2006 | 16804382 |
| commensal oral bacteria antigens prime human dendritic cells to induce th1, th2 or treg differentiation. | in various immunopathologic conditions, bacterial flora induce an immune response which results in inflammatory manifestations, e.g. periapical granuloma. dendritic cells provide the main orchestration of specific immune responses. the aim of our study was to test the capacity of distinct oral bacterial antigens (prepared from streptococcus mitis, propionibacterium acnes, and bacteroides spp.) to prime human dendritic cells for stimulation of the t-lymphocyte response. to assess the t-lymphocyte ... | 2006 | 16390334 |
| gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. | the pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of propionibacterium acnes within the follicle. in an attempt to understand the specific genes involved in inflammatory acne, we performed gene expression profiling in acne patients. skin biopsies were obtained from an inflammatory papule and from normal skin in six patients with acne. biopsies were also taken from normal skin of six subjec ... | 2006 | 16528362 |
| anti-inflammatory activity of cationic peptides: application to the treatment of acne vulgaris. | cationic antimicrobial peptides exhibit potent antimicrobial activity against clinically relevant microorganisms including propionibacterium acnes. recent studies showed that, in addition to the antimicrobial activity, these peptides can exhibit an anti-inflammatory effect. these properties make cationic peptides attractive drug candidates for the treatment of acne vulgaris, a disease with both bacterial and inflammatory components. this review focuses on the anti-inflammatory activity of cation ... | 2006 | 16553825 |
| links between propionibacterium acnes and prostate cancer. | incidental foci of prostate cancer are found at autopsy in 30% of men in their third decade, and by their eighth decade more than 75% have histological evidence of cancer. this unprecedented cancer prevalence points to a ubiquitous causative agent or perhaps an interaction between multiple common carcinogenic cofactors. we propose that one of these carcinogens is propionibacterium acnes. several characteristics of prostate cancer suggest the involvement of an infectious agent and we provide evid ... | 2006 | 16563091 |
| protective effects of a neutral polysaccharide isolated from the mycelium of antrodia cinnamomea on propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice. | mycelia of antrodia cinnamomea were extracted with chloroform and hot water. a neutral polysaccharide named acn2a separated from the water extract was purified using 10% ccl3cooh, and repeated column chromatography on hw-65 and de-52 cellulose. its structure was determined by chemical and spectroscopic analyses. acn2a was composed of gal, glc, fuc, man and galn (in the ratio 1:0.24:0.07:0.026:faint), in which an alpha-d-(1-->6)-gal linkage accounted for 73% of all linkages. the ratio of branch p ... | 2006 | 16595952 |
| clinical significance of brand versus generic formulations: focus on oral minocycline. | minocycline is an oral antibiotic widely prescribed throughout the world, primarily for the treatment of acne vulgaris; other uses include the treatment of rosacea and perioral dermatitis. in the united states, propionibacterium acnes resistance is lowest with minocycline compared with other tetracyclines and with erythromycin. the availability of generic formulations of minocycline has created confusion regarding the clinical significance of brand versus generic minocycline products. this artic ... | 2006 | 16610733 |
| in vitro activities of daptomycin, vancomycin, and penicillin against clostridium difficile, c. perfringens, finegoldia magna, and propionibacterium acnes. | daptomycin has in vitro activity against gram-positive anaerobic bacteria, although limited numbers of species have been tested. we studied the in vitro activities of daptomycin, vancomycin, and penicillin against more than 100 strains each of clostridium difficile, c. perfringens, finegoldia magna, and propionibacterium acnes. daptomycin etest mics and results from time-kill studies were determined for selected strains. for 392 of 421 strains (93%), daptomycin was inhibitory at < or =1 microg/m ... | 2006 | 16870765 |
| adjuvant effect of the propionibacterium acnes and its purified soluble polysaccharide on the immunization with plasmidial dna containing a trypanosoma cruzi gene. | in the present work we investigated the role of killed propionibacterium acnes or a soluble polysaccharide extracted from bacterium cell wall in modulated experimental immunization with plasmidial dna. we used a plasmid, p154/13, containing a gene-encoding catalytic domain of trypanosoma cruzi (t. cruzi) trans-sialidase. as previously described, immunization of balb/c mice with p154/13 elicited humoral, cell-mediated and protective immune responses against t. cruzi infection. in this study we de ... | 2006 | 16625047 |
| propionibacterium acnes dna from an explanted intraocular lens detected by polymerase chain reaction in a case of chronic pseudophakic endophthalmitis. | we report a case of propionibacterium acnes dna from the explanted intraocular lens (iol) a 76-year-old man with delayed-onset chronic endophthalmitis. the detection was by polymerase chain reaction (pcr). slitlamp microscopic examination showed cells and flare in the anterior chamber, keratic precipitates on the endothelium, and multiple white plaques on both surfaces of the iol. propionibacterium acnes dna was found in both the aqueous humor and the explanted iol by pcr. scanning electron micr ... | 2006 | 16631069 |