Publications

corynebacterium diphtheriae endocarditis.	two patients with corynebacterium diphtheriae endocarditis have been observed in the past ten years. both cases occurred sporadically. in one case toxigenic c. diphtheriae caused endocarditis in an immunized child with congenital heart disease. the second patient developed rapidly progressive valve destruction caused by a nontoxigenic strain of c. diphtheriae. these cases illustrate that c. diphtheriae may produce endocarditis in addition to its previously described diseases spectrum.	1976	820199
current status of passive immunity to diphtheria and tetanus in the newborn.	the extent of transplacentally derived immunity to the toxins of corynebacterium diphtheriae and clostridium tetani was assessed by a hemagglutination technique using the cord sera of a group of infants recently born in bronx, new york. protective levels of antitoxin to c. diphtheriae were found in 64% of the infants. tetanus antitoxin was present in sufficient quantity for protection in 38% of the cord sera. while this degree of immunity reepresents an improvement over that achieved 20 years ag ...	1976	1245766
[studies on the frequency of corynebacterium diphtheriae carriers among students of the elementary schools in bari].	the morbidity of diphtheria reported in bari in 1970 and in 1971 was 17.1 and 19.1 for 100000 inhabitants; in the same years the national average was respectively 1.6 and 1.3. in a epidemiological research carried out in the same period in 1017 school-children of bari not previously selected, 45 carriers of c. diphtheriae (4.42%) were identified. toxigen strains were isolated from 11 carriers (1.08%). the frequency of carriers was higher in the school-children 9-11 years aged (6-04%), lower in t ...	1975	820281
[studies on the diffusion of corynebacterium diphtheriae carriers in a children's community].	during an epidemiological inquiry in a infantile community it was founded the 22.8% of 83 children was carrier of toxigen c. diphtheriae and two adults on 15 were carriers of non toxigen c. diphtheriae. the isolated species respectively from children and adults were of different phagic type.	1975	820282
diphtheria toxin: mode of action and structure.		1975	164179
the action of vibrio cholerae and corynebacterium diphtheriae neuraminidases on the sendai virus receptor of human erythrocytes.	studies of the sendai virus haemagglutinin receptor on the human erythrocyte surface have confirmed that it involves 2 leads to 3 linked sialic acid. because the primary specificity of vibrio cholerae neuraminidase is for this linkage, it is able to compete with the virus for the receptor, to which it adsorbs strongly at low temperatures. corynebacterium diphtheriae neuraminidase, whose principal specificity is for a sialic acid linkage other than 2 leads to 3, does not easily remove sendai viru ...	1975	168311
[changes in the antibacterial effects of organs and tissues of ornithodoros papillipes birula ticks].		1975	234572
the bacteriological ecosystem of the skin of children in an african tropical envirovment (tanzania).	using a standardized method for sampling, the aerobic microbial flora of the skin of ninety-five children in dar es salaam, tanzania, was studied qualitatively and quantitatively. the subjects comprised three groups; group a, thirty-seven normal infants (below the age of 1 year); group b, twenty-nine infants with various bacterial skin lesions; and group c, twenty-nine nursery school children between 4-5 and 7 years. the following observations were made: (i) the quantitative results indicated; ( ...	1975	239739
interaction of toxin of corynebacterium diphtheriae with phagocytes from susceptible and resistant species.	the interaction of the toxin of corynebacterium diphtheriae with leukocytes from sensitive and resistant animal species was examined by determining the ability of toxin to inhibit protein synthesis by several types of phagocytic cell. small amounts of toxin (25 minimal lethal doses) impaired protein synthesis in both polymorphonuclear leukocytes and mononuclear cells from humans and guinea pigs, whereas large amounts (2,000 minimal lethal doses) were required for minimal inhibition of mouse phag ...	1975	804024
letter: clinical diphtheria from nontoxigenic corynebacterium?		1975	804026
[action of decamethoxin on diphtherial exotoxin].	the results of the study of the detoxicating effect of decamethoxin on diphtheria toxin are presented. it was noted that decamethoxin in subbacteriostatic concentrations inhibited the process of the toxin production in corynebacteria diphtheriae. the detoxicating effect of the drug was clearly evident when used in a concentration of 10gamma/ml at a 2-hour exposure. decamethoxin in a dose of 0.1 gamma/ml neutralized the effect of the diphtheria toxin on contact for 24 hours.	1975	804292
biologically active components from mycobacterial cell walls. iii. production of experimental allergic encephalomyelitis in guinea-pigs.	the efficacy of various fractions of mycobacterial cell walls in producing experimental ahlergic encephalomyelitis (eae) has been evaluated. bcg (bacillus-calmette-buérin) cell walls were effective in producing eae in all animals at dose levels as low as 40 mug. study of subfractions of these cell walls revealed the following: (1) wax d was active, but required larger doses than bcg cell walls; (2) the chloroform-methanol-soluble (cms) portion of wax d and p3 (a mycolic acid-trehalose ester cont ...	1975	804436
new method for the large-scale preparation of diphtheria toxoid: purification of toxin.	diphtheria toxin of high purity was prepared in batch cultures of 1 to 40 liters by procedures capable of processing 200-liter batches without modification. the procedure incorporates preliminary purification of the growth medium and, after deep fermentation or sulfate culture of corynebacterium diphtheriae, both concentration and partial purification of the toxin by membrane ultrafiltration. final purification is achieved by sephadex g-100 gel filtration. purities of 2,000 to 2,500 flocculation ...	1975	804848
the role of cutaneous diphtheria infections in a diphtheria epidemic.	twenty-four people with diptheria and 48 carriers were found in an isolated, circumscribed, rural area during a one-month period. four patients had cutaneous lesions, which were similar to those of typical impetigo, form which corynebacterium diptheriae was isolated. these cases constituted an epidemiologic focus from which the other cases were infected. ten of 52 classroom contacts of two patients with skin infections harbored c. diphtheriae in the pharynx, while only eight of 132 classroom con ...	1975	805182
letter: diphtheria carriers.		1975	806244
adjuvant activity of mycobacterial fractions. i. purification and in vivo adjuvant activity of cell wall skeletons of mycobacterium bovis bcg, nocardia asteroides 131 and corynebacterium diphtheriae pw8.	the adjuvant activity of cell wall skeletons (mycolic acid-arabino-galactan-mucopeptide, cws) prepared from the cells of mycobacteria, nocardia and corynebacteria was examined in vivo in mice and guinea pigs. the cell wall skeletons of mycobacterium bovis bcg (bcg-cws), nocardia asteroides 131 and corynebacterium diphtheriae pwc suspended in freund's incomplete adjuvant (fia) as water-in-oil emulsions showed potent adjuvant activity on the formation of circulating antibody and cell-mediated immu ...	1975	807194
skin infections and the epidemiology of diphtheria: acquisition and persistence of c diphtheriae infections.	acquisition and persistence of c. diphtheriae infections of skin lesions and of the respiratory tract were observed in households exposed to c. diphtheriae carriers in a community experiencing a diphtheria outbreak and in households in two communities free of the disease. acquisition of c. diphtheriae was more frequent in epidemic households, apparently due to a greater frequency of respiratory tract acquisition. skin lesion acquisition was constant in both situations. the pattern of persistence ...	1975	808123
evidence for an infectious etiology of rheumatoid arthritis.		1975	808992
scabies and other skin diseases in pre-school children in ujamaa villages in tanzania.	a survey of skin diseases was carried out in pre-school children in five ujamaa villages in rufiji district and 532 children (5.3% of the total population) were screened. the results showed that scabies was the commonest skin problem affecting 31% of the children. primary pyoderma and fungal infections were relatively less common and accounted for 7.0 and 2.4% respectively. staphylococcus aureus, group a beta haemolytic streptococci and corynebacterium diphteriae were the commonest pathogeneic b ...	1975	810929
bacterial skin infections in preschool and school children in coastal tanzania.	in coastal tanzania, 1,855 preschool and school children were studied for pyoderma (superficial bacterial infections of the skin exclusive of secondarily infected scabies) and for scabies. the predisposing personal, socleoeconomic, and hygienic variables for both conditions were studied also. pyoderma lesions and some secondarily infected scabies were cultured aerobically for bacterial isolates and the predisposing factors were determined by interviews, home visits, and physical examinations. py ...	1975	811175
numerical analysis of the characteristics of corynebacterium diphtheriae strains isolated in victoria from 1962 to 1971.	a study of the incidence of diphtheria in the state of victoria, australia, was carried out. numerical analysis of the characteristics of 264 strains of corynebacterium diphtheriae isolated between 1962 and 1971 placed them into 18 varieties plus six strains which were unique in their combination of reactions to the characteristics examined. during the 10-year period, some varieties appeared intermittently and were recognized by certain defining characteristics but exhibited a gradual change in ...	1975	811707
adjuvant activity of mycobacterial fractions. iii. adjuvant effect of cell wall of mycobacterium bovis bcg on cell-mediated cytotoxicity in mice.	a quantitative assay and characterization of oil-attached cell wall of mycobacterium bovis bcg (bcg-cws) which stimulates cell-mediated immunity of spleen cells to alloantigens in mice were carried out by an in vitro cell-mediated cytotoxicity test using 51cr-labeled target cells. c57bl/6j mice (h-2b) were immunized intraperitoneally with mastocytoma cells (h-2d) with or without oil-attached bcg-cws. the cytotoxicity, comparable to that of spleen cells from mice immunized with mastocytoma cells ...	1975	811834
[pathogenetic aspects of the "healthy" diphtheria bacteria carrier state].		1975	812302
[patterns of antimicrobial immunity in carriers of toxigenic diphtheria bacteria].	it was shown in the passive hemagglutination test (phat) with a type-specific somatic antigen on 147 carriers of toxigenic diphtheria bacilli that the phat titres of 1/80 and over were determined in 64% of bacteria. in the process of carrier state of toxigenic bacteria antimicrobial antibodies were detected in 79% of the children; after the release from the carrier state, the percentage was from 57 to 26, depending on the time lapse after it. among the carriers of nontoxigenic diphtheria bacilli ...	1975	812306
[study of the reasons for a decrease in the inoculability of diphtheria bacteria].	it was shown that the seeding efficacy of diphtheria bacilli depended not only on the state of the epidemic process, but also on the correct methodical approach to the examination. a combination of the qualitative and epidemiological choice of the groups of population for bacteriological examination with the use of blood tellurite media permitted to increase the efficacy of investigations, with a considerable reduction of the number of analyses.	1975	812307
[enzymatic properties of neuraminidase from corynebacterium diptherial].	enzymatic properties of neuraminidase isolated from non-toxigenic strain c7 of diphteritic bacteria are studied. the enzyme has the ph optimum 5.5--6.0 in acetate buffer and the temperature optimum 38 degrees c. neuraminidase has the highest substrate affinity to glycoproteins of equine blood serum, the lowest affinity--to 3-n-acetylneuraminosyllactose and ovomucin. the km values was 4.3-10(-4) at optimal conditions under the hydrolysis of 3-n-acetylneuraminosyllactose, vm was 0.05+/-0.02 mum na ...	1975	812557
[antibacterial activity of a lysozyme-like enzyme from staphylococci].	a lysozyme-like enzyme isolated from the culture broth of staph. aureus 712 presented in its native state a lipoproteid complex. the lytic and antibacterial spectrum of the enzyme was similar to that of the egg albumin enzyme. however, the lipoproteid complex was somewhat superior to the egg albumin complex in its activity against micrococcus lysodeikticus, a number of gramnegative bacteria and staphylococci. out of the organisms studied microccus lysodeikticus, sarcina and bac. subtilis proved ...	1975	813563
[use of the corycin test and of bacteriophage typing for genetic marking of corynebacteria with reference to c. diphtheriae of the gravis type].	nontoxigenic c. diphtheria, fermenting starch, of convertible phage types abcdfch, abcdfg, abcdf, abcd, abd, acdf, cdf, af and a, and also strains of nonconvertible bacteriophage types i, h and k proved to be noncoricynogenic in the corycine test and weakly sensitive to bacteriocin of the no. 3463 test strain (a study was made of a total of 502 strains). strains (383) isolated from 354 patients and carriers--starch-fermenting and toxigenic to the gravis type--were toxigenic were lysed by a combi ...	1975	814754
[the effect of neuraminidase of c. diphtheriae on the functional capacity of the peritoneal exudate cells of guinea pigs to diphtheria bacilli].	a study was made of the effect of neuraminidase preparation containing no diphtheria toxin admixtures and hyaluronidase on the phagocytic activity of macrophages. neuraminidase produced a stimulating effect on the cells of the developing macrophage culture. the macrophages treated with the enzyme increased their capacity to digestion of nontoxigenic diphtheria bacilli.	1975	814758
[the antibacterial effect of organs and tissues of hyalomma dromedarii, hyalomma anatolicum and ixodes persulcatus ticks].		1975	815775
studies on diphtheria in bombay.		1975	815957
iron and diphtheria toxin production.		1975	815958
level of redox potential as a possible contributing influence in the pathogenicity of oral anaerobes.	dental plaque anaerobes may be associated with the etiology of periodontal disease. this has created an interest in the potential pathogenicity of oral anaerobes. we compared the metabolic activity of anaerobic corynebacteria (c. parvum, c. anaerobium) and corresponding aerobic species (c. diphtheriae, c. xerosis). the anaerobes exhibited lower levels of rna synthesis, ranging from 5 to 10 fold over the aerobes. we further examined these anaerobes, plus actinomyces naeslundi n16 (isolated from t ...	1975	816253
studies on diphtheria infection in and around delhi (a bacteriological study from faucial and cutaneous lesions).		1975	816969
[microbiological characteristics and sensitivity to antibiotics of decamethoxin-resistant diphtheric bacilli].	biological properties and sensitivity of 6 corynebacteria strains to 9 antibiotics were studied in vitro. the rate of the development of resistance to neomycin, levomycetin, decamine and decamethoxin in the diphtheria causative agents was determined. biological properties of the decamethoxin resistant variants of the diphtheria causative agents were investigated: 100 passages on media with increasing amounts of the drug. the rate of the development of resistance to decamethoxin was slower than t ...	1975	817649
mitogenicity of corynebacterium parvum for mouse lymphocytes.	corynebacterium parvum, a powerful in vivo immunostimulant, is shown to stimulate lymphocyte proliferation in vitro. c. parvum is mitogenic for b lymphocytes and does not stimulate t cells. the mitogenicity is dependent on the presence of macrophages. c. diphtheriae and another strain of c. parvum, both of which are devoid of adjuvant, res stimulation, and tumour-inhibiting activities in vivo are nevertheless mitogenic. a lipid-free fraction from c. parvum, which retains in vivo immunostimulator ...	1975	817854
genetic basis of toxin production and pathogenesis in vibrio cholerae: evidence against phage conversion.	the pathogenicity of vibrio cholerae strains "cured" of "kappa-type" phage was not significantly altered relative to that of their "kappa" lysogenic parental strains. unlike corynebacterium diphtheriae, the capacity of v. cholerae to produce exotoxin was not stimulated as a consequence of active phage multiplication. toxin production in cultures in which kappa-type phage multiplication was initiated either by inducing kappa lysogens or by infecting naturally occurring or "cured" kappa-sensitive ...	1975	1090531
production and characterization of exotoxin(s) of shigella dysenteriae type 1.	a semicontinuous fermenter system was developed in which broth culture filtrates of shigella dysenteriae type 1 yielded substantial amounts of exotoxin. biologic activity of the exotoxin was characterized by means of three assays: the rabbit ileal loop for fluid evocation (enterotoxicity), mouse lethality after parenteral injection (neurotoxicity), and hela cell toxicity in vitro (cytotoxicity). although the culture filtrate was highly active, disc electrophoresis revealed that the toxin is a mi ...	1975	1092769
bacterial interference by streptococcus salivarius.	a strain of streptococcus salivarius, recognized in a throat culture because of its inhibition of the growth of a species of corynebacterium, was studied in vitro to determine its antagonistic effects agains various other bacteria. it was found to be inhibitory to anaerobic gram-positive cocci, streptococci belonging to lancefields groups a, c, f, and g, and corynebacterium diphtheriae, c. hofmanii, and c. xerosis.	1975	1155368
immunoadjuvant activities of cell walls and their water-soluble fractions prepared from various gram-positive bacteria.	the cell walls from all 21 species of gram-positive bacteria examined, except lysozyme-susceptible micrococcus lysodeikticus (nctc 2665) and lysozyme-resistant staphylococcus epidermidis (atcc 155), were found to be definitely adjuvant-active in both stimulation of increased serum antibody levels and induction of delayed-type hypersensitivity to ovalbumin when administered to guinea-pigs as water-in-oil emulsions. using various cell wall lytic enzymes, the immunoadjuvant principles were solubili ...	1975	1180872
letter: recognition of diphtheria.		1975	46974
letter: avirulent corynebacteria.		1975	47127
letter: recognition of diphtheria.		1975	47573
non-toxigenic corynebacterium diphtheriae in a boarding school.	a non-toxigenic strain of corynebacterium diphtheriae var. gravis was isolated from 31 boys during an outbreak of sore throats at a boarding school of 15 staff and 134 pupils. despite the non-toxigenicity of the strain involved, conventional isolation procedures were observed and all boys at the school were treated with antibiotics. restrictions on the school were only relaxed when no further carriers were detected. the rationale of such management of an episode involving a non-toxigenic strain ...	1975	48687
letter: recognition of diphtheria.		1975	48850
[bacteriological studies of butirosin sulfate, a new aminoglycoside antibiotic (author's transl)].		1975	51941
quantitative assay of diphtherial toxin and of immunologically cross-reacting proteins by reversed passive hemagglutination.	a reversed passive hemagglutination (rpha) assay for diptherial toxin has been developed. antitoxic antibodies were isolated from commercially available equine diptherial antitoxin by immunoabsorption using highly purified diphtherial toxin covalently linked to sepharose 4b. formalinized, tanned sheep erythrocytes sensitized with the purified antitoxic antibodies are specifically agglutinated by diphtherial toxin but are not agglutinated by extracellular antigens of corynebacterium diptheriae th ...	1975	54339
analysis of corynebacterium vaginale by an immunodiffusion technique.	an immunodiffusion technique was employed to study the antigenic relationship of corynebacterium vaginale isolates, vaginal diphtheroids, and members of the genera corynebacterium and lactobacillus. antisera were prepared against c. vaginale atcc strain 14018 grown diphasically and on blood agar plates and were tested against extracts of organisms prepared by sonication. ouchterlony analysis demonstrated that all of the isolates of c. vaginale examined possess a common antigenic determinant. no ...	1974	4132956
[diphtheria toxin: the molecular biology of an infection].		1974	4136339
diphtheria in the manchester area 1967-1971.		1974	4140991
[the estimation of the molecular weight of bacterial neuraminidases by gel-filtration (author's transl)].		1974	4155210
[bacterial lipids].		1974	4156687
synthesis of diphtheria tox-gene products in escherichia coli extracts.	in a protein-synthesizing system extracted from e. coli, purified dna from corynephages betac(tox+) and beta45c was used to direct the in vitro synthesis of diphtheria toxin and of the related nontoxic protein, crm45, as well as of other beta-phage proteins. when betac(tox+)-dna or betac-dna was added to a similar system extracted from the nonlysogenic corynebacterium diphtheriae strain, c7(s)(-)(tox-), neither toxin nor the crm45 protein was produced, although other beta-phage proteins were syn ...	1974	4204202
diphtheria in the united states, 1959-1970.		1974	4204238
[typing of corynebacterium diphtheriae by means of bacteriophages in epidemiological studies of diplitheria].		1974	4205669
synthesis of diphtheria toxin in e. coli cell-free lysate.		1974	4207356
[carbenicillin].		1974	4207805
corynebacterium diphtheriae infections in tanzania.		1974	4209307
diphtheria toxin and mutant proteins.		1974	4209928
influence of corynebacterium diphtheriae and pseudodiphtheriae on embryonic quinea pig cell cultures. ii. ultrastructural studies on infected culture cells.		1974	4209991
[antibiotic from bac. cereus var. mycoides. 1].		1974	4211301
diphtheria.		1974	4211927
further studies on corynebacterium species capable of producing diphtheria toxin (c. diphtheriae, c. ulcerans, c. ovis).		1974	4212024
influence of acids and salts on the efficiency of the dialyser in the automated analysis of sialic acid.		1974	4212087
synergistic action of increased oxygen tensions and paba-folic acid antagonists on bacterial growth.		1974	4212378
the isolation of symbiotic streptococci.		1974	4212426
[diphtherial bacteriophage in the pharynx of carriers].		1974	4212615
[so-called conditionally pathogenic microorganisms (a review)].		1974	4212818
diphtheria deaths in the united states, 1959-1970.		1974	4213033
structure of wet specimens in electron microscopy. improved environmental chambers make it possible to examine wet specimens easily.	several recent technological advances have increased the practicality and usefulness of the technique of electron microscopy of wet objects. (i) there have been gains in the effective penetration of high-voltage microscopes, scanning transmission microscopes, and high-voltage scanning microscopes. the extra effective penetration gives more scope for obtaining good images through film windows, gas, and liquid layers. (ii) improved methods of obtaining contrast are available (especially dark field ...	1974	4213401
biologically active components of the cells of gram-positive bacteria.		1974	4214181
transformation of organic compounds by microbial enzymes.		1974	4214719
first cases of diphtheria in aruba (dutch west indies).		1974	4214857
isolation of type - specific substances from corynebacterium diphthermiae cells.		1974	4214859
treatment of diphtheria carriers: benzathine penicillin, erythromycin, and clindamycin.		1974	4215352
persisting bacteriophage infections, lysogeny, and phage conversions.		1974	4215366
structure and immunological properties of d-arabino-d-galactans isolated from cell walls of mycobacterium species.		1974	4215801
[skin manifestations in diphtheria carriers].		1974	4216147
the occurrence of vaginal diphtheroids in papanicolaou smears.		1974	4216225
factors influencing natural immunization in diphtheria in urban and rural communities in west bengal.		1974	4216571
diphtheria carriers among school chidren in poona.		1974	4216580
[study of the antibacterial effect of organs and tissues of the tick hyalomma asiaticum (ixodidae)].		1974	4217426
absorption of polymyxin e (colistin) by corynebacterium diphtheriae.		1974	4217558
[use of phage typing for deciphering group illness with diphtheria in closed collectives for adolescents].		1974	4218010
[change in convertant phagotypes of non-toxigenic c. diphtheriae type gravis following infection by tox+-viruses].		1974	4218019
[the effect of horse serum on bacterial sensitivity to penicillins].		1974	4218022
[location of ferritin labeled antibodies within the bacterial cell].		1974	4218030
comparative studies on culture media used for sterility testing.		1974	4218566
[clomethacillin. synthesis and antibacterial properties].		1974	4218940
[morphology of bacteriophages of the genus corynebacterium. comparative aspects].		1974	4208057
[comparative results of seeding corynebacterium diphtheriae from different nutrient media].		1974	4208496
[comparative characteristics of antigen fractions of corynebacterium diphtheriae].		1974	4208497
[warning on the possibility of diphtheria infection in pediatric nurses on children's departments].		1974	4208576
[changes in the secondary structure of bacterial dna on exposure to small doses of ionizing radiation].		1974	4209015
separation of proteins by high-speed pressure liquid chromatography.		1974	4363441
bacterial interference among strains of staphylococcus aureus in man.		1974	4365948
affinity chromatography purification of diphtheria toxin.		1974	4369765
application of measurement and control of dissolved oxygen pressure to vaccine production.		1974	4369790
stability of dtp vaccine.		1974	4372231
[studies on the problem of growth of seperated microorganisms on glass-fiber fine-dust and glass-fiber high-capacity-floating-particle filters].		1974	4373308