Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| genotypic detection and molecular epidemiology of extended-spectrum beta-lactamase-producing escherichia coli and klebsiella pneumoniae in a regional hospital in central taiwan. | this study was conducted to detect the genes encoding extended-spectrum beta-lactamases (esbls) and determine the epidemiological relatedness of 69 escherichia coli and 33 klebsiella pneumoniae isolates collected from a regional hospital in central taiwan, mostly from inpatients (e. coli 87.0%; k. pneumoniae 88.0%). the phenotypes of these isolates were examined according to the combination disc method recommended by the clinical and laboratory standards institute. most of the esbl-producing e. ... | 2010 | 20150317 |
| risk factors in community-acquired urinary tract infections caused by esbl-producing bacteria in children. | in this study, risk factors were investigated in children with community-acquired urinary tract infections (uti) caused by extended-spectrum beta-lactamases (esbl)-producing e. coli or klebsiella spp. one hundred and fifty-five patients were diagnosed with esbl-positive uti (case group) in the outpatient clinics of hacettepe university children's hospital between 1 january 2004 and 31 december 2006. a control group, 155 out of 4,105 children, was matched by age and sex among children with esbl-n ... | 2010 | 20151161 |
| relaxing the coenzyme specificity of 1,3-propanediol oxidoreductase from klebsiella pneumoniae by rational design. | 1,3-propanediol has wide applications for large volume markets, particularly in the polymer business. microbial production of 1,3-propanediol has been considered as a competitor to the traditional petrochemical routes. however, the formation of 1,3-propanediol is limited by the amount of nadh supplied by the oxidative pathway of glycerol dismutation. previous metabolic flux analysis revealed that relaxation of the coenzyme specificity of 1,3-propanediol oxidoreductase for both nadh and nadph wou ... | 2010 | 20156491 |
| extended-spectrum beta-lactamase-producing bacteria and vesicoureteral reflux in children. | 2010 | 20158657 | |
| fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, enterobacteriaceae infections: a systematic review. | rising rates of resistance to antimicrobial drugs among enterobacteriaceae limit the choice of reliably active forms of these drugs. we evaluated the evidence on fosfomycin as a treatment option for infections caused by members of the family enterobacteriaceae with advanced resistance to antimicrobial drugs, including producers of extended-spectrum beta-lactamase (esbl). we systematically reviewed studies evaluating the antimicrobial activity, or the clinical effectiveness of fosfomycin. 17 anti ... | 2010 | 20129148 |
| response to the letter to the editor by j silver 're: case report: a fatal metastasis of klebsiella pneumonia of the lungs'. | 2010 | 20142833 | |
| 2,3-dihydroxypropane-1-sulfonate degraded by cupriavidus pinatubonensis jmp134: purification of dihydroxypropanesulfonate 3-dehydrogenase. | 2,3-dihydroxypropane-1-sulfonate (dhps) is a widespread intermediate in plant and algal transformations of sulfoquinovose (sq) from the plant sulfolipid sulfoquinovosyl diacylglycerol. further, dhps is recovered quantitatively during bacterial degradation of sq by klebsiella sp. strain abr11. dhps is also a putative precursor of sulfolactate in e.g. ruegeria pomeroyi dss-3. a bioinformatic approach indicated that some 28 organisms with sequenced genomes might degrade dhps inducibly via sulfolact ... | 2010 | 20150239 |
| antimicrobial susceptibility of moxifloxacin against gram-negative enteric rods from colombian patients with chronic periodontitis. | gram-negative enteric rods were associated with periodontal diseases in several populations. the association between enteric and putative periodontal pathogens has received little attention in the literature. the present investigation determined the occurrence and in vitro antimicrobial susceptibility of isolates of gram-negative enteric rods from colombian patients with chronic periodontitis. | 2010 | 20151809 |
| "typhlitis" in rectum. | 2010 | 20158643 | |
| klebsiella oxytoca-positive, penicillin-associated hemorrhagic enterocolitis in children. | 2010 | 20158656 | |
| [urinary pneumococcal or legionella antigen detection tests and low-spectrum antibiotic therapy for community-acquired pneumonia]. | we performed urinary antigen tests for pneumococcus and legionella for patients with community-acquired pneumonia (cap), to prescribe a documented antibiotic therapy. we report the efficiency of low-spectrum antibiotic treatment, illustrating the inappropriateness of bacteriological respiratory sampling. | 2010 | 20172672 |
| alterations in cytokines and effects of dexamethasone immunosuppression during subclinical infections of invasive klebsiella pneumoniae with hypermucoviscosity phenotype in rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) macaques. | invasive klebsiella pneumoniae with the hypermucoviscosity phenotype (hmv k. pneumoniae) is an emerging human pathogen that also has been attributed to fatal multisystemic disease in african green monkeys at our institution. combining a cluster of subclinically infected macaques identified in march and april 2008 and the animals documented during a subsequent survey of more than 300 colony nonhuman primates yielded a total of 9 rhesus macaques and 6 cynomolgus macaques that were subclinically in ... | 2010 | 20158951 |
| efflux pumps are involved in the defense of gram-negative bacteria against the natural products isobavachalcone and diospyrone. | the activities of two naturally occurring compounds, isobavachalcone and diospyrone, against documented strains and multidrug-resistant (mdr) gram-negative bacterial isolates were evaluated. the results indicated that the two compounds exhibited intrinsic antibacterial activity against several gram-negative bacteria, and their activities were significantly improved in the presence of an efflux pump inhibitor (mic values decreased to below 10 microg/ml). in addition, the activities of isobavachal ... | 2010 | 20160051 |
| risk factors for bloodstream infection with klebsiella pneumoniae producing vim-1 metallo-beta-lactamase. | to identify risk factors for bloodstream infections (bsis) caused by vim-1-producing klebsiella pneumoniae (vpkp). | 2010 | 20106862 |
| in vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: nationwide data from the smart programme. | this nationwide surveillance of clinically important bacteria from the intensive care units (icus) of major teaching hospitals throughout taiwan investigated the susceptibilities to doripenem and other comparator carbapenems from september through november 2005. minimum inhibitory concentrations (mics) were determined for 1,311 clinical isolates using the broth microdilution method according to clinical and laboratory standards institute (clsi) 2005 guidelines. doripenem showed similar (within f ... | 2010 | 20108018 |
| successful control of an outbreak of klebsiella pneumoniae carbapenemase-producing k. pneumoniae at a long-term acute care hospital. | to determine the effect of a bundle of infection control interventions on the horizontal transmission of klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae during an outbreak. | 2010 | 20175685 |
| molecular characterisation of trimethoprim resistance in escherichia coli and klebsiella pneumoniae during a two year intervention on trimethoprim use. | trimethoprim resistance is increasing in enterobacteriaceae. in 2004-2006 an intervention on trimethoprim use was conducted in kronoberg county, sweden, resulting in 85% reduction in trimethoprim prescriptions. we investigated the distribution of dihydrofolate reductase (dfr)-genes and integrons in escherichia coli and klebsiella pneumoniae and the effect of the intervention on this distribution. | 2010 | 20169085 |
| natural history of colonization with gram-negative multidrug-resistant organisms among hospitalized patients. | to determine the anatomic sites and natural history of colonization with gram-negative multidrug-resistant organisms (mdros). | 2010 | 20175687 |
| sialidase-based anti-influenza virus therapy protects against secondary pneumococcal infection. | das181 (fludase) is a sialidase fusion protein in clinical development as a broad-spectrum anti-influenza virus (ifv) therapeutic agent. previous reports by other investigators have raised the concern that desialylation of airway epithelium might increase susceptibility to streptococcus pneumoniae infection. | 2010 | 20170378 |
| sepsis and its etiology among hospitalized children less than 1 year of age with intestinal failure on parenteral nutrition. | infections accompany intestinal failure (if) more commonly in children than in adults, with reported incidences of 2% to 29%. appropriate care of the central venous catheter is the most important factor preventing infections; but in addition, bacteria translocate from the dysmotile gut as a possible source of septicemia. the aim of this retrospective analysis was to investigate the rate and the epidemiologic profile of septicemia in the patient group at greatest risk, namely, children less than ... | 2010 | 20172274 |
| international nosocomial infection control consortium (inicc) report, data summary for 2003-2008, issued june 2009. | we report the results of the international infection control consortium (inicc) surveillance study from january 2003 through december 2008 in 173 intensive care units (icus) in latin america, asia, africa, and europe. during the 6-year study, using centers for disease control and prevention (cdc) us national healthcare safety network (nhsn; formerly the national nosocomial infection surveillance system [nnis]) definitions for device-associated health care-associated infection, we collected prosp ... | 2010 | 20176284 |
| influencing factors in the occurrence of injured coliforms in the drinking water distribution system in the city of la plata, argentina. | the objective of this study was to evaluate the influencing factors in the occurrence of coliforms in the drinking water in la plata (argentina) from june 1999 to june 2001. a total of 180 samples were collected from rio de la plata (102 samples) and puelche aquifer (78 samples); 45 samples were collected for each of the four seasons. the membrane filter procedure was used for isolating bacteria, and each sample was tested for chlorine and ph. the highest percentage of samples positive for colif ... | 2010 | 20154384 |
| susceptibility of carbapenemase-producing strains of klebsiella pneumoniae and escherichia coli to the direct antibacterial activity of nab739 and to the synergistic activity of nab7061 with rifampicin and clarithromycin. | to determine the susceptibility of carbapenemase-producing strains of klebsiella pneumoniae and escherichia coli to the direct antibacterial activity of nab739 and to the synergistic activity of nab7061 with rifampicin and clarithromycin. nab739 and nab7061 are novel polymyxin derivatives that lack the cationic charges in the linear peptide portion of polymyxin b and have pharmacokinetic properties different from those of polymyxin b. | 2010 | 20167589 |
| pediatric urinary tract infections in a tertiary care center from north india. | paediatric urinary tract infections (uti) are associated with high morbidity and long term complications like renal scarring, hypertension, and chronic renal failure. a cause of occult febrile illness, they often remain undiagnosed. we studied the clinical and microbiologic profile and antibiotic resistance profile of such infections in paediatric uti patients at our center. | 2010 | 20167982 |
| antimicrobial activity of the extracts of craniotome furcata (lamiaceae). | craniotome furcata (link.) o. kuntze (lamiaceae) is used in the traditional medicine for the treatment of cuts and wounds indicating antimicrobial activity. | 2010 | 20176098 |
| [postoperative infection due to contaminated propofol]. | seven patients operated on in a period of two consecutive days in the havenziekenhuis, rotterdam, the netherlands developed symptoms of sepsis following a relatively minor procedure. one patient developed fever and hypotension a few hours after surgery, and developed thrombocytopenia and leucopenia. postoperative bleeding occurred as a result of the thrombocytopenia, necessitating further surgery. this patient developed serious multi-organ failure, and required prolonged intensive care treatment ... | 2010 | 20170564 |
| emergence of kpc-producing klebsiella pneumoniae in italy. | abstract: | 2010 | 20178590 |
| surfactant protein b propeptide contains a saposin-like protein domain with antimicrobial activity at low ph. | surfactant protein b (sp-b) proprotein contains three saposin-like protein (saplip) domains: a saplip domain corresponding to the mature sp-b peptide is essential for lung function and postnatal survival; the function of saplip domains in the n-terminal (sp-bn) and c-terminal regions of the proprotein is not known. in the current study, sp-bn was detected in the supernatant of mouse bronchoalveolar lavage fluid (balf) and in nonciliated bronchiolar cells, alveolar type ii epithelial cells, and a ... | 2010 | 20007532 |
| resistance development profiling of piperacillin in combination with the novel {beta}-lactamase inhibitor bli-489. | to evaluate development of resistance to the piperacillin/bli-489 combination. | 2010 | 20008048 |
| new 1,3-oxazolo[4,5-c]quinoline derivatives: synthesis and evaluation of antibacterial and antituberculosis properties. | a new class of fused oxazoloquinoline derivatives was synthesized starting from 2-bromo-1-phenylethanones 1a-b through multi-step reactions. the newly synthesized compounds were evaluated for their in vitro antibacterial against escherichia coli (attc-25922), staphylococcus aureus (attc-25923), pseudomonas aeruginosa (atcc-27853) and klebsiella pneumoniae (recultured) and antituberculosis activity against mycobacterium tuberculosis h37rv (atcc 27294). preliminary results indicated that most of t ... | 2010 | 20034708 |
| antimicrobial susceptibility of multidrug-resistant (mdr) and extensively drug-resistant (xdr) enterobacteriaceae isolates to fosfomycin. | the advancing antimicrobial drug resistance among enterobacteriaceae renders the evaluation of potential novel therapeutic options necessary. we sought to evaluate the in vitro antimicrobial activity of fosfomycin against multidrug-resistant (mdr) enterobacteriaceae isolates. antimicrobial susceptibility to fosfomycin and 12 additional antibiotics of mdr enterobacteriaceae isolates collected between november 2007 and april 2009 at the university hospital of heraklion, crete, greece, was examined ... | 2010 | 20034765 |
| klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. | human beta-defensins (hbds) contribute to the protection of the respiratory tract against pathogens. it is reasonable to postulate that pathogens have developed countermeasures to resist them. klebsiella pneumoniae capsule polysaccharide (cps), but not the lipopolysaccharide o antigen, mediated resistance against hbd1 and hbd2. hbd3 was the most potent hbd against klebsiella. we investigated the possibility that as a strategy for survival in the lung, k. pneumoniae may not activate the expressio ... | 2010 | 20008534 |
| in vivo selection of imipenem-resistant klebsiella pneumoniae producing extended-spectrum beta-lactamase ctx-m-15 and plasmid-encoded dha-1 cephalosporinase. | four klebsiella pneumoniae isolates (kp1-4) were recovered sequentially from an infected patient. whilst kp1-3 were resistant to all beta-lactams except carbapenems, kp4 recovered after 24 days of imipenem-containing treatment showed additional resistance to carbapenems. no carbapenem hydrolysis could be identified in kp4. molecular characterisation revealed that kp1-4 were indistinguishable by pulsed-field gel electrophoresis, contained a 95-kb self-transferable plasmid harbouring bla(ctxm-15) ... | 2010 | 20034767 |
| colistin therapy for microbiologically documented multidrug-resistant gram-negative bacterial infections: a retrospective cohort study of 258 patients. | it is unclear whether the effectiveness of polymyxins depends on the site of infection, the responsible pathogen, dosage, and monotherapy vs. combination therapy. we investigated colistin therapy in a large, retrospective, single-centre, cohort study. primary analysis outcomes were infection outcome, survival and nephrotoxicity. over a 7-year period (october 2000 to october 2007), 258 patients received intravenous (i.v.) colistin for at least 72h for microbiologically documented multidrug-resist ... | 2010 | 20006471 |
| k2 serotype klebsiella pneumoniae causing a liver abscess associated with infective endocarditis. | klebsiella pneumoniae primary liver abscess (kpla) is an emerging disease that is associated with distant septic complications. we report the first case of kpla associated with infective endocarditis. the k. pneumoniae strain was a hypermucoid k2 serotype carrying the rmpa virulence-associated gene. | 2010 | 20007381 |
| skull base infection presenting with multiple lower cranial nerve palsies. | diseases of the temporal bone causing lower cranial nerve palsies are uncommon. in the presence of bony erosion, they are highly suggestive of a malignant process. however, when there is a clear history of otitis externa in an immunocompromised or diabetic patient, a diagnosis of osteomyelitis and secondary inflammatory mass should be considered. we report 4 separate cases of infective skull base lesions causing multiple lower cranial nerve palsies in elderly patients who were not immunocompromi ... | 2010 | 20015773 |
| comparative study on characteristics of azo dye decolorization by indigenous decolorizers. | this study provides a first attempt to explore indigenous strains with excellent decolorization capability from the most biodiverse region in taiwan for dye-bearing wastewater treatment. bacterial isolates were obtained via serial selections under selection pressure of the fungicide nystatin and model textile dye(s). according to profiles of protein expression and pcr-augmented 16s rrna gene analyses for strain identification, >99% of nucleotide sequences in isolated strains were identical to ty ... | 2010 | 19944603 |
| the designer proline-rich antibacterial peptide a3-apo is effective against systemic escherichia coli infections in different mouse models. | antimicrobial peptides are considered to be viable alternatives to conventional antibiotics. however, they rarely show systemic efficacy in animal models when added at non-toxic doses. the dimer a3-apo was designed to attack both the bacterial membrane and the enterobacteriaceae-specific domain of the heat shock protein dnak in order to reduce toxicity whilst maintaining activity. the peptide exhibited a minimal inhibitory concentration (mic) range of 2-128 mg/l against 28 clinical escherichia c ... | 2010 | 20031377 |
| clonal dissemination of klebsiella pneumoniae carbapenemase kpc-3 in long beach, california. | carbapenems (carbs) are the primary treatment for infections caused by extended-spectrum beta-lactamase (esbl)-producing klebsiella pneumoniae strains. production of a serine carbapenemase, kpc, is increasing alarmingly in the united states and is probably contributing to carb resistance rates. we describe the clinical and molecular characteristics of four infections caused by kpc-3 k. pneumoniae strains. | 2010 | 20032252 |
| prevalence, molecular characterization, and phenotypic confirmation of extended-spectrum beta-lactamases in escherichia coli, klebsiella pneumoniae, and klebsiella oxytoca at the radboud university nijmegen medical centre in the netherlands. | the prevalence and molecular types of extended-spectrum beta-lactamases (esbls) were determined during a 1-year period in unselected clinical nonduplicate isolates of escherichia coli (n = 1,738), klebsiella pneumoniae (n = 436), and klebsiella oxytoca (n = 208), cultured at the university medical centre nijmegen, the netherlands. isolates identified as esbl producer by the phoenix automated system were collected prospectively and subjected to molecular analysis for the most common esbls tem, sh ... | 2010 | 20001741 |
| antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines. | a new series of indolo[1,2-c]quinazoline derivatives were prepared in good yield through reaction of 2-(o-aminophenyl)indole with a variety of arylaldehydes. the structures of the newly synthesized compounds were confirmed by ir, (1)h nmr, (13)c nmr and mass spectral studies and elemental analysis. all the title compounds were investigated for their activity against certain strains of gram-positive bacteria (staphylococcus aureus, bacillus subtilis and streptococcus pyogenes), gram-negative bact ... | 2010 | 20005020 |
| an outbreak of infection due to beta-lactamase klebsiella pneumoniae carbapenemase 2-producing k. pneumoniae in a greek university hospital: molecular characterization, epidemiology, and outcomes. | we describe the emergence and spread of klebsiella pneumoniae carbapenemase 2 (kpc-2)-producing k. pneumoniae at a greek university hospital. | 2010 | 20041768 |
| slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin. | thiolactomycin (tlm), a natural product thiolactone antibiotic produced by species of nocardia and streptomyces, is an inhibitor of the beta-ketoacyl-acyl carrier protein synthase (kas) enzymes in the bacterial fatty acid synthase pathway. using enzyme kinetics and direct binding studies, tlm has been shown to bind preferentially to the acyl-enzyme intermediates of the kasi and kasii enzymes from mycobacterium tuberculosis and escherichia coli. these studies, which utilized acyl-enzyme mimics in ... | 2010 | 20018879 |
| international spread and persistence of tem-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an inca/c2 plasmid containing tn1696::tn1 and is5075-tn21. | tem-24 remains one of the most widespread tem-type extended-spectrum beta-lactamases (esbls) among enterobacteriaceae. to analyze the reasons influencing its spread and persistence, a multilevel population genetics study was carried out on 28 representative tem-24 producers from belgium, france, portugal, and spain (13 enterobacter aerogenes isolates, 6 escherichia coli isolates, 6 klebsiella pneumoniae isolates, 2 proteus mirabilis isolates, and 1 klebsiella oxytoca isolate, from 1998 to 2004). ... | 2010 | 19995930 |
| dynamics of human complement-mediated killing of klebsiella pneumoniae. | with an in vitro system that used a luminescent strain of klebsiella pneumoniae to assess bacterial metabolic activity in near-real-time, we investigated the dynamics of complement-mediated attack in healthy individuals and in patients presenting to the emergency department with community-acquired severe sepsis. a novel mathematical/statistical model was developed to simplify light output trajectories over time into two fitted parameters, the rate of complement activation and the delay from acti ... | 2010 | 20008281 |
| emergence of clonally related klebsiella pneumoniae isolates of sequence type 258 producing kpc-2 carbapenemase in belgium. | 2010 | 20008447 | |
| cloverleaf test (modified hodge test) for detecting carbapenemase production in klebsiella pneumoniae: be aware of false positive results. | the aim of this study was to evaluate the presence of carbapenemases in a klebsiella pneumoniae collection and the performance of the modified hodge test (mht) to correctly identify this phenotype. | 2010 | 19996141 |
| [clinical aspects and epidemiology of uncomplicated cystitis in women. german results of the aresc study]. | uncomplicated cystitis in women is among the most frequent infections in the community setting. the german results of the international aresc study are reported concerning clinical aspects, epidemiology, and antimicrobial susceptibility of uropathogens. | 2010 | 19943031 |
| distribution of bla(tem), bla(shv), bla(ctx-m) genes among clinical isolates of klebsiella pneumoniae at labbafinejad hospital, tehran, iran. | extended-spectrum beta-lactamase (esbl)-producing isolates of klebsiella pneumoniae have been increasingly recognized in the hospital settings in iran as well as throughout the world. the aim of this study was to detect and determine the genes encoding the esbls including bla(tem), bla(shv), and bla(ctx-m) groups among the k. pneumoniae isolates at labbafinejad hospital by polymerase chain reaction (pcr) and characterize them by direct sequencing of pcr products. eighty-nine isolates were isolat ... | 2010 | 19961397 |
| comparison of the activity of a human simulated, high-dose, prolonged infusion of meropenem against klebsiella pneumoniae producing the kpc carbapenemase versus that against pseudomonas aeruginosa in an in vitro pharmacodynamic model. | we have previously demonstrated that a high-dose, prolonged-infusion meropenem regimen (2 g every 8 h [q8h]; 3-hour infusion) can achieve 40% free drug concentration above the mic against pseudomonas aeruginosa with mics of <or=16 microg/ml. the objective of this experiment was to compare the efficacy of this high-dose, prolonged-infusion regimen against carbapenemase-producing klebsiella pneumoniae isolates with the efficacy against p. aeruginosa isolates having similar meropenem mics. an in vi ... | 2010 | 19995927 |
| in vitro activity of fosfomycin against blakpc-containing klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin. | in vitro activity of fosfomycin was evaluated against 68 bla(kpc)-possessing klebsiella pneumoniae (kpkpc) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. by agar dilution, 93% of the overall kpkpc were susceptible (mic(50/90) of 16/64 microg/ml, respectively). the subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (mic(50/90) of 32/128 microg/ml, respectively). notably, 5 out of 6 extremely drug-resistant (tigecyclin ... | 2010 | 19901089 |
| susceptibility to tigecycline of isolates from samples collected in hospitalized patients with secondary peritonitis undergoing surgery. | activity of tigecycline against nosocomial secondary peritonitis isolates collected along 18 months in 29 spanish hospitals was tested by etest in a central laboratory, considering food and drug administration (fda)/british society for antimicrobial chemotherapy (bsac)/european committee on antimicrobial susceptibility testing (eucast) breakpoints. a total of 600 facultative/aerobic isolates (392 gram negative, 208 gram positive) and 100 anaerobes were tested. none of the 220 escherichia coli is ... | 2010 | 20022193 |
| simocyclinone d8 turns on against gram-negative bacteria in a clinical setting. | simocyclinone d8 (sd8) is known to affect gram-positive bacteria only. by testing sd8 against several clinical isolates, we showed that sd8 resulted very active against gram-negative bacteria from clinical specimens, while it was shown inactive against laboratory strains. the activity against the former was in part due to enhanced drug entry. in addition, sd8 appears to share chromosome- and plasmid-mediated resistance mechanisms with fluoroquinolones. | 2010 | 20022496 |
| synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles. | novel 1,5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1h-pyrazole-3-carboxamides (2a-e, 3, 3a-f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1h-pyrazole-3-yl)thiazoles (6a-c,7, 8, 9a-c, 10, 11) were synthesized by varying the active part (amide group) of pyrazole, characterized using ir, (1)h nmr, mass spectral data and screened for their antibacterial activity against escherichia coli (attc-25922), staphylococcus aureus (attc-25923), pseudomonas aeruginosa (attc-27853), ... | 2010 | 20053480 |
| incidence and bacteriology of burn infections at a military burn center. | considerable advancements in shock resuscitation and wound management have extended the survival of burned patients, increasing the risk of serious infection. we performed a 6-year review of bacteria identification and antibiotic susceptibility records at the us army institute of surgical research burn center between january 2003 and december 2008. the primary goal was to identify the bacteria recovered from patients with severe burns and determine how the bacteriology changes during extended ho ... | 2010 | 20045259 |
| detection of kpc in acinetobacter spp. in puerto rico. | during an island-wide pcr-based surveillance study of beta-lactam resistance in multidrug-resistant (mdr) escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, and acinetobacter calcoaceticus-baumannii complex isolates obtained from 17 different hospitals, 10 kpc-positive acinetobacter isolates were identified. dna sequencing of the bla(kpc) gene identified kpc-2, -3, and -4 and a novel variant, kpc-10. this is the first report of a kpc-type beta-lactamase identified in acinetobacter ... | 2010 | 20038618 |
| metabolism of (-)-epigallocatechin gallate by rat intestinal flora. | anaerobic metabolism of (-)-epigallocatechin gallate (egcg) by rat intestinal bacteria was investigated in vitro. first, intestinal bacteria which are capable of hydrolyzing egcg to (-)-epigallocatechin (egc) and gallic acid (2) were screened with 169 strains of enteric bacteria. as a result, enterobacter aerogenes, raoultella planticola, klebsiella pneumoniae susp. pneumoniae, and bifidobacterium longum subsp. infantis were found to hydrolyze egcg. subsequent steps of egcg metabolism are degrad ... | 2010 | 20043675 |
| antibacterial effect of nsaids on clinical isolates of urinary tract infection and diabetic foot infection. | non steroidal anti-inflammatory drugs (nsaids) are a group of chemically dissimilar agents that have primary effect of inhibition of prostaglandin's synthesis. aspirin (acetyl salicylic acid) is used as an analgesic, anti pyretic, anti-inflammatory agent and also have an anticoagulant effect. tylenol (acetaminophen) is used as pain reliever. the objective of this study was to determine the effect of aspirin and tylenol against clinical isolates of urinary tract infection (uti) and diabetic foot ... | 2010 | 20067876 |
| autoimmune diseases: solution of the environmental, immunological and genetic components with principles for immunotherapy and transplantation. | autoimmune diseases have environmental and genetic components. these are the microbial trigger, the immunity system component and the genetic component. here we describe these components and how they interact. known microbial triggers are streptococcus pyogenes for rheumatic carditis, proteus mirabilis for rheumatoid arthritis and klebsiella pneumoniae for ankylosing spondylitis. the immunity system component has been clarified by realisation that no autoimmune disease is caused by loss of suppr ... | 2010 | 20083235 |
| human pathogens abundant in the bacterial metagenome of cigarettes. | many studies have evaluated chemical, heavy metal, and other abiotic substances present in cigarettes and their roles in the development of lung cancer and other diseases, yet no studies have comprehensively evaluated bacterial diversity of cigarettes and the possible impacts of these microbes on respiratory illnesses in smokers and exposed nonsmokers. | 2010 | 20064769 |
| molecular characterization of extended-spectrum beta-lactamases in clinical escherichia coli and klebsiella pneumoniae isolates from surabaya, indonesia. | no detailed reports regarding extended-spectrum beta-lactamase (esbl)-producing enterobacteriaceae are currently available from indonesia, the fourth most populous country in the world. | 2010 | 20053690 |
| cytotoxic effects of klebsiella oxytoca strains isolated from patients with antibiotic-associated hemorrhagic colitis or other diseases caused by infections and from healthy subjects. | antibiotic-associated hemorrhagic colitis (aahc) is associated with klebsiella oxytoca. this study analyzed whether cytotoxic properties are linked to specific subtypes of k. oxytoca. klebsiella isolates from stools of aahc patients, healthy carriers, and diarrhea patients as well as from infections of other organs were investigated. cytotoxic effects on human epithelial cells were limited to the species k. oxytoca and were not detectable for any other klebsiella species. isolates from aahc pati ... | 2010 | 20053860 |
| changing spectrum of microbiology of liver abscess: now klebsiella, next burkholderia pseudomallei. | 2010 | 20079999 | |
| exopolysaccharide production by nitrogen-fixing bacteria within nodules of medicago plants exposed to chronic radiation in the chernobyl exclusion zone. | nitrogen-fixing bacteria isolated from root nodules of medicago plants growing in the 10 km zone around the chernobyl nuclear power plant were screened for the production of new water-soluble acidic exopolysaccharides (epss). the different strains belonged to the enteriobacteriaceae family (enterobacter ludwigii, raoultella terrigena, klebsiella oxytoca), except for one which belonged to the rhizobiaceae family (sinorhizobium meliloti). all of the bacteria produced highly viscous eps with an ave ... | 2010 | 20080178 |
| genesis of a kpc-producing klebsiella pneumoniae after in vivo transfer from an imported greek strain. | we document here the in vivo transfer of bla(kpc-2) between intensive care unit-acquired and a commensal strain of k. pneumoniae in a french patient after his repatriation from greece. this first report of an emerging kpc-producing strain in france raises further concerns about the spread of carbapenem resistance among enterobacteriaceae. | 2010 | 20067746 |
| antimicrobial resistance among clinical isolates from the chinese meropenem surveillance study (cmss), 2003-2008. | the chinese meropenem surveillance study (cmss) programme was initiated in 2003 with the aim of monitoring the antimicrobial activity of broad-spectrum agents against nosocomial gram-negative bacilli in china. from 2003 to 2008, a total of 3892 isolates were collected from 10 teaching hospitals. the minimum inhibitory concentrations (mics) of 11 antimicrobial agents were determined by the agar dilution method. during the study period, a marked decrease in the susceptibility of acinetobacter spp. ... | 2010 | 20047820 |
| low frequency of antibiotic resistance among urine isolates of escherichia coli in the community, despite a major hospital outbreak with klebsiella pneumoniae producing ctx-m-15 in uppsala county. | a screening programme introduced during a major outbreak of a klebsiella pneumoniae strain producing extended spectrum beta-lactamase (esbl), indicated a dissemination of esbl-producing escherichia coli in the community. a total of 360 urine samples, yielding 205 isolates, were therefore collected from primary care patients with lower urinary tract infections (uti) in uppsala county. the susceptibility pattern of the isolates was investigated with the disk diffusion method. the majority of the p ... | 2010 | 20085420 |
| curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during klebsiella pneumoniae b5055-induced lung infection in balb/c mice. | acute lung injuries due to acute lung infections remain a major cause of mortality. thus a combination of an antibiotic and a compound with immunomodulatory and anti-inflammatory activities can help to overcome acute lung infection-induced injuries. curcumin derived from the rhizome of turmeric has been used for decades and it exhibits anti-inflammatory, anti-carcinogenic, immunomodulatory properties by downregulation of various inflammatory mediators. keeping these properties in mind, we invest ... | 2010 | 20056776 |
| important methodological considerations with respect to differentiation of ctx-m-15 and ctx-m-28 extended-spectrum beta-lactamases. | 2010 | 20061778 | |
| genetic determinants of antibiotic resistance in diarrheagenic klebsiella pneumoniae subspecies ozaenae: an emerging enteropathogen in senegal. | 2010 | 20064035 | |
| direct ertapenem disk screening method for identification of kpc-producing klebsiella pneumoniae and escherichia coli in surveillance swab specimens. | klebsiella pneumoniae carbapenemase (kpc) production in gram-negative bacilli is an increasing problem worldwide. rectal swab surveillance is recommended as a component of infection prevention programs, yet few screening methods are published. we compared detection of kpc-producing klebsiella pneumoniae and escherichia coli in surveillance specimens by 2 methods: (i) inoculation of swabs in tryptic soy broth containing 2 microg/ml imipenem followed by plating to macconkey agar (mac) (method 1) a ... | 2010 | 20071553 |
| kpc-2-producing klebsiella pneumoniae in brazil: a widespread threat in waiting? | 2010 | 19889563 | |
| klebsiella pneumoniae acrab efflux pump contributes to antimicrobial resistance and virulence. | respiratory infections caused by klebsiella pneumoniae are characterized by high rates of mortality and morbidity. management of these infections is often difficult, due to the high frequency of strains that are resistant to multiple antimicrobial agents. multidrug efflux pumps play a major role as a mechanism of antimicrobial resistance in gram-negative pathogens. in the present study, we investigated the role of the k. pneumoniae acrrab operon in antimicrobial resistance and virulence by using ... | 2010 | 19858254 |
| in vitro activities of antimicrobials against six important species of gram-negative bacteria isolated from raw milk samples in korea. | gram-negative bacteria (gnb) with multidrug resistance pose a serious threat to public health. they are environmental pathogens frequently isolated from raw milk and mastitis in dairy cattle. this study was to examine the in vitro antimicrobial activities against 225 isolates belonging to six important species of gnb from mastitic raw milk samples of dairy herds in the republic of korea: acinetobacter baumannii (n = 17), citrobacter freundii (n = 19), enterobacter cloacae (n = 54), klebsiella pn ... | 2010 | 19895257 |
| distribution and antimicrobial resistance of clinical and subclinical mastitis pathogens in dairy cows in rhône-alpes, france. | the goal of this study was to estimate the distribution of pathogens, as well as their antimicrobial resistance pattern, in cows affected by clinical or subclinical mastitis in the rhône-alpes region of france. a total of 1770 samples were taken between january 2007 and march 2008, leading to the identification of 1631 bacterial isolates. streptococcus uberis (22.1%), escherichia coli (16%), and coagulase-positive staphylococci (15.8%) were identified as the major causative agents of clinical ma ... | 2010 | 19919286 |
| uranium(vi) reduction and removal by high performing purified anaerobic cultures from mine soil. | biological uranium reduction was investigated using bacteria isolated from a uranium mine in limpopo, south africa. background uranium concentration in soil from the mine was determined to be 168 mgkg(-1) much higher than the typical background uranium concentration in natural soils (0.30-11.7 mgkg(-1)). therefore it was expected that the bacteria isolated from the site were resistant to u(vi) toxicity. preliminary studies using a non-purified consortium from the mine soil showed that u(vi) [ura ... | 2010 | 19883933 |
| molecular and biochemical characterization of the natural chromosome-encoded class a beta-lactamase from pseudomonas luteola. | pseudomonas luteola (formerly classified as cdc group ve-1 and named chryseomonas luteola) is an unusual pathogen implicated in rare but serious infections in humans. a novel beta-lactamase gene, bla(lut-1), was cloned from the whole-cell dna of the p. luteola clinical isolate lam, which had a weak narrow-spectrum beta-lactam-resistant phenotype, and expressed in escherichia coli. this gene encoded lut-1, a 296-amino-acid ambler class a beta-lactamase with a pi of 6 and a theoretical molecular m ... | 2010 | 19884377 |
| isolation and characterization of two members of the siderophore-microcin family, microcins m and h47. | in this paper we provide the first biochemical evidence of the existence of a family of structure-related antimicrobial peptides, the siderophore-microcins, in the enterobacteriaceae family. we isolated and characterized two novel siderophore-microcins, mccm and mcch47, previously characterized through genetic studies. mccm and mcch47 were expressed from several escherichia coli strains containing the microcin gene clusters. the spectra of their bactericidal activities were found to be restricte ... | 2010 | 19884380 |
| [prevalence of extended-spectrum beta-lactamases of the ctx-m type producing escherichia coli and klebsiella pneumoniae in bretonneau hospitals (chru tours)]. | the ctx-m type extended spectrum beta-lactamases constitute a rapidly growing cluster of enzymes that have disseminated geographically. this study evaluates the prevalence of these enzymes in the university hospital in tours, in 2007. twenty-eight strains were studied: 21 escherichia coli and seven klebsiella pneumoniae. the gene bla(ctx-m) was detected by real-time pcr for 27 strains. the ctx-m-1 group, including ctx-m-15, was the most frequent ctx-m-type enzyme. | 2010 | 19892477 |
| expression of dha operon required for 1,3-pd formation in escherichia coli and saccharomyces cerevisiae. | the 1,3-propanediol (1,3-pd) synthesis operon (dha operon) was mainly composed of four genes: dhab, dhat, gdra, and gdrb, which encoded glycerol dehydratase, 1,3-pd oxidoreductase and reactivating factor for glycerol dehydratase, respectively. in the present study, dha operon was cloned from 1,3-pd producing strain klebsiella pneumoniae. heterologous expression of cloned dha operon was carried out in escherichia coli and saccharomyces cerevisiae w303-1a, respectively. the results indicated that ... | 2010 | 19924483 |
| authors' reply to: re: a vim-1 metallo-beta-lactamase-producing klebsiella pneumoniae clinical isolate in an acute hospital in germany. | 2010 | 19892527 | |
| [kpc carbapenemases: what is at stake in clinical microbiology?]. | emergence and dissemination of carbapenem resistance in the world represent a significant threat for management of hospital-acquired infections. from the early 2000s, enterobacteriaceae that produce klebsiella pneumoniae carbapenemases (kpc) have initially been reported from the usa and now worldwide, becoming the most important carbapenemase. these kpc producing-bacteria are mostly involved in nosocomial and systemic infections. they are mostly enterobacteriaceae and more rarely pseudomonas aer ... | 2010 | 19854586 |
| attributable hospital cost and length of stay associated with health care-associated infections caused by antibiotic-resistant gram-negative bacteria. | determination of the attributable hospital cost and length of stay (los) are of critical importance for patients, providers, and payers who must make rational and informed decisions about patient care and the allocation of resources. the objective of the present study was to determine the additional total hospital cost and los attributable to health care-associated infections (hais) caused by antibiotic-resistant, gram-negative (gn) pathogens. a single-center, retrospective, observational compar ... | 2010 | 19841152 |
| evaluation of new chromogenic substrates for the detection of coliforms. | to evaluate a new range of chromogenic substrates for the detection of beta-galactosidase activity in coliforms and to compare their performance in agar media and broths. | 2010 | 19878523 |
| use of automated repetitive-sequence-based pcr for rapid laboratory confirmation of nosocomial outbreaks. | rapid and reliable diagnosis of genetic relatedness of clinical isolates in microbiologic laboratory is essential in case of nosocomial outbreak investigation. most molecular techniques used to type microorganisms are technically demanding and time consuming. currently repetitive-sequence-based pcr (rep-pcr) technique has been adapted to an automated format on the diversilab system (biomérieux, marcy l'etoile, france). aim of this study was to compare the performance of the diversilab system to ... | 2010 | 19879293 |
| chromium (vi) biotransformation by beta- and gamma-proteobacteria from natural polluted environments: a combined biological and chemical treatment for industrial wastes. | the high solubility of cr(vi) in aqueous systems, together with carcinogenic and mutagenic effects on living organisms, make industrial effluents receive specific treatments for cr(vi) elimination. biotreatments, based on biotransformation of cr(vi) to cr(iii) which is immobilized as cr(oh)(3), are the most effective methods for the removal of cr(vi) concentrations below 2mm. the aim of our study is the application of pure or mixed bacterial cultures for cr(vi) biotransformation followed by chem ... | 2010 | 19879691 |
| antimicrobial substances produced by coliform strains active against foodborne pathogens. | in the present study, 31 coliform strains were isolated from salad, cheese, and meat products sold in commercial establishments in rio de janeiro city, and were tested for antibiotic resistance and antimicrobial substance production. thirteen strains (41.9%) were resistant to at least one antibiotic tested, among which one presented resistance to nine different antibiotics. two strains (6.4%) exhibited inhibitory activity against the indicator strains, escherichia coli lmifrj and salmonella ente ... | 2010 | 19895262 |
| impact of a change in antibiotic prophylaxis on total antibiotic use in a surgical intensive care unit. | the aim of this study was to evaluate the impact of reducing the length of antibiotic prophylaxis for cerebro spinal shunts on total antibiotic use and key resistant pathogens. | 2010 | 19904488 |
| beverages obtained from soda fountain machines in the u.s. contain microorganisms, including coliform bacteria. | ninety beverages of three types (sugar sodas, diet sodas and water) were obtained from 20 self-service and 10 personnel-dispensed soda fountains, analyzed for microbial contamination, and evaluated with respect to u.s. drinking water regulations. a follow-up study compared the concentration and composition of microbial populations in 27 beverages collected from 9 soda fountain machines in the morning as well as in the afternoon. ice dispensed from these machines was also examined for microbial c ... | 2010 | 19926155 |
| proteomic analysis of the effect of cyanide on klebsiella oxytoca. | cyanide has been proved to be degraded by klebsiella oxytoca. in order to examine the physiological responses of cyanide degradation by this bacterium, two-dimensional (2-de) electrophoresis approach and maldi-tof-ms allow us to identify 106 proteins spots that were significantly altered in the presence of 1 mm cyanide in relative to that in 1 mm ammonia when k. oxytoca grown at the late-log phase. among them, 27 proteins were successfully identified. these proteins were involved in carbohydrate ... | 2010 | 19921330 |
| microbial fed-batch production of 1,3-propanediol using raw glycerol with suspended and immobilized klebsiella pneumoniae. | the production of 1,3-propanediol (1,3-pd) was investigated with klebsiella pneumoniae dsm 4799 using raw glycerol without purification obtained from a biodiesel production process. fed-batch cultures with suspended cells revealed that 1,3-pd production was more effective when utilizing raw glycerol than pure glycerol (productivity after 47 h of fermentation, 0.84 g l(-1) 1 h(-1) versus 1.51 g l(-1) h(-1) with pure and raw glycerol,respectively). in addition, more than 80 g/l of 1,3-pd was produ ... | 2010 | 19921491 |
| a novel tetrabranched antimicrobial peptide that neutralizes bacterial lipopolysaccharide and prevents septic shock in vivo. | we describe the nonnatural antimicrobial peptide kkirvrlsa (m33) and its capacity to neutralize lps-induced cytokine release, preventing septic shock in animals infected with bacterial species of clinical interest. m33 showed strong resistance to proteolytic degradation when synthesized in tetrabranched form with 4 peptides linked by a lysine core, making it suitable for use in vivo. hplc and mass spectrometry demonstrated its stability in serum beyond 24 h. m33 was found to be very selective fo ... | 2010 | 19917670 |
| vim-19, a metallo-beta-lactamase with increased carbapenemase activity from escherichia coli and klebsiella pneumoniae. | two carbapenem-resistant isolates, one escherichia coli isolate and one klebsiella pneumoniae isolate, recovered from an algerian patient expressed a novel vim-type metallo-beta-lactamase (mbl). the identified bla(vim-19) gene was located on a ca. 160-kb plasmid and located inside a class 1 integron in both isolates. vim-19 differed from vim-1 by the asn215lys and ser228arg substitutions, increasing its hydrolytic activity toward carbapenems. site-directed mutagenesis experiments showed that bot ... | 2010 | 19917750 |
| novel vim metallo-beta-lactamase variant from clinical isolates of enterobacteriaceae from algeria. | five different strains of bacteria belonging to the family enterobacteriaceae were isolated from two patients hospitalized in the intensive care unit of the central military hospital of algiers, algeria. all five strains, one providencia stuartii strain, two escherichia coli strains, and two klebsiella pneumoniae strains, were intermediate or resistant to all beta-lactams, including carbapenems. synergy between imipenem and edta was observed for all five strains. the results of the pcr experimen ... | 2010 | 19901092 |
| consequences of cps mutation of klebsiella pneumoniae on 1,3-propanediol fermentation. | the filtration in 1,3-propanediol (1,3-pd) downstream process is influenced by the large amounts of capsular polysaccharides (cps) produced by klebsiella pneumoniae cgmcc 1.6366. the morphological and fermentation properties were investigated with the cps-deficient mutant k. pneumoniae cgmcc 1.6366 cps. similar biomass was obtained with cgmcc 1.6366, and the mutant strain in batch cultures indicating the cell growth was slightly inhibited by cps defection. the viscosity of fermentation broth by ... | 2010 | 19936735 |
| predictive factors for mortality and need for nephrectomy in patients with emphysematous pyelonephritis. | to analyse the factors predicting the mortality and need for nephrectomy in patients with emphysematous pyelonephritis (epn). | 2010 | 19930181 |
| the phev phenylalanine trna gene klebsiella pneumoniae clinical isolates is an integration hotspot for possible niche-adaptation genomic islands. | horizontally acquired genomic islands may allow bacteria to conquer and colonize previously uncharted niches. four klebsiella pneumoniae trna gene insertion hotspots (arg6, asn34, met56, and phev) in 101 clinical isolates derived from blood, sputum, wound, bile or urine specimens were screened by long-range pcr for the presence or absence of integrated islands. the phev phenylalanine trna gene was the most frequently occupied site and harbored at least three entirely distinct types of islands: ( ... | 2010 | 19921332 |
| epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia. | all bacterial isolates from 7058 patients admitted to haemato-oncology wards at national taiwan university hospital between 2002 and 2006 were characterized. in total 1307 non-duplicate bloodstream isolates were made from all patients with haematological malignancy; 853 (65%) of these were from neutropenic patients. gram-negative bacteria predominated (60%) in neutropenic isolates with escherichia coli (12%), klebsiella pneumoniae (10%), acinetobacter calcoaceticus-baumannii complex (6%), and st ... | 2010 | 19941686 |
| port central venous catheters-associated bloodstream infection during outpatient-based chemotherapy. | central venous catheters (cvcs) are commonly used for the administration of intravenous chemotherapy in outpatient setting. nevertheless, outbreaks of catheter-associated bloodstream infections had been reported from oncology centers. we describe a large outbreak of cvcs-associated klebsiella oxytoca bloodstream infection, occurring in an oncology chemotherapy outpatient unit of northern greece between october 2006 and may 2007. the outbreak involved approximately 10% of the patients with cvcs w ... | 2010 | 19967570 |
| effect of biodiesel-derived raw glycerol on 1,3-propanediol production by different microorganisms. | the microbial production of 1,3-propanediol (1,3-pd) from raw glycerol, a byproduct of biodiesel production, is economically and environmentally advantageous. although direct use of raw glycerol without any pretreatment is desirable, previous studies have reported that this could cause inhibition of microbial growth. in this study, we investigated the effects of raw glycerol type, different microorganisms, and pretreatment of raw glycerol on the production of 1,3-pd. raw glycerol from waste vege ... | 2010 | 19937397 |